> top > docs > PMC:7408073 > spans > 13827-15276 > annotations

PMC:7408073 / 13827-15276 JSONTXT

Annnotations TAB JSON ListView MergeView

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T94 1008-1012 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T95 1064-1068 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T22 91-115 Body_part denotes renin-angiotensin system http://purl.obolibrary.org/obo/UBERON_0018229
T23 117-120 Body_part denotes RAS http://purl.obolibrary.org/obo/UBERON_0018229
T24 1064-1068 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
497 0-3 Gene denotes ACE Gene:59272
498 8-12 Gene denotes ACE2 Gene:59272
499 123-127 Gene denotes ACE2 Gene:59272
500 273-283 Gene denotes bradykinin Gene:3827
501 300-311 Gene denotes B1 receptor Gene:623
502 338-346 Gene denotes Ang (1–9 Gene:284
503 382-415 Gene denotes ACE/Ang II/Ang II type 1 receptor Gene:1636
504 417-421 Gene denotes AT1R Gene:185
505 594-615 Gene denotes nitric oxide synthase Gene:4843
506 857-860 Gene denotes ACE Gene:59272
507 876-880 Gene denotes ACE2 Gene:59272
508 921-925 Gene denotes AT1R Gene:185
509 1151-1155 Gene denotes ACE2 Gene:59272
510 1314-1318 Gene denotes ACE2 Gene:59272
511 1282-1285 Gene denotes ACE Gene:59272
512 324-332 Gene denotes Ang (1–7 Gene:284
513 184-192 Gene denotes Ang (1–7 Gene:284
514 539-542 Gene denotes AT2 Gene:186
515 914-920 Gene denotes Ang II Gene:24179
516 971-982 Chemical denotes aldosterone MESH:D000450
517 469-480 Disease denotes hypotension MESH:D007022
518 814-825 Disease denotes dysfunction MESH:D009461
519 984-996 Disease denotes inflammation MESH:D007249
520 1028-1038 Disease denotes thrombosis MESH:D013927
521 1040-1059 Disease denotes cardiac dysfunction MESH:D006331

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T121 469-480 Disease denotes hypotension http://purl.obolibrary.org/obo/MONDO_0005468
T122 984-996 Disease denotes inflammation http://purl.obolibrary.org/obo/MONDO_0021166
T123 1028-1038 Disease denotes thrombosis http://purl.obolibrary.org/obo/MONDO_0000831

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T149 221-224 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T150 237-244 http://purl.obolibrary.org/obo/PR_000018263 denotes peptide
T151 312-322 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T152 348-356 http://purl.obolibrary.org/obo/PR_000018263 denotes peptides
T153 630-640 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T154 707-708 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T155 812-813 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T156 934-944 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T157 1008-1012 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T158 1064-1068 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T159 1064-1068 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T160 1156-1164 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T74 21-25 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T76 97-108 Chemical denotes angiotensin http://purl.obolibrary.org/obo/CHEBI_48433
T77 117-120 Chemical denotes RAS http://purl.obolibrary.org/obo/CHEBI_63620
T78 138-149 Chemical denotes angiotensin http://purl.obolibrary.org/obo/CHEBI_48433
T79 151-154 Chemical denotes Ang http://purl.obolibrary.org/obo/CHEBI_48433
T80 162-164 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T81 170-173 Chemical denotes Ang http://purl.obolibrary.org/obo/CHEBI_48433
T82 184-187 Chemical denotes Ang http://purl.obolibrary.org/obo/CHEBI_48433
T83 237-244 Chemical denotes peptide http://purl.obolibrary.org/obo/CHEBI_16670
T84 266-269 Chemical denotes Arg http://purl.obolibrary.org/obo/CHEBI_16467|http://purl.obolibrary.org/obo/CHEBI_29952
T86 273-283 Chemical denotes bradykinin http://purl.obolibrary.org/obo/CHEBI_3165
T87 324-327 Chemical denotes Ang http://purl.obolibrary.org/obo/CHEBI_48433
T88 338-341 Chemical denotes Ang http://purl.obolibrary.org/obo/CHEBI_48433
T89 348-356 Chemical denotes peptides http://purl.obolibrary.org/obo/CHEBI_16670
T90 386-389 Chemical denotes Ang http://purl.obolibrary.org/obo/CHEBI_48433
T91 390-392 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T92 393-396 Chemical denotes Ang http://purl.obolibrary.org/obo/CHEBI_48433
T93 397-399 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T94 594-606 Chemical denotes nitric oxide http://purl.obolibrary.org/obo/CHEBI_16480
T95 601-606 Chemical denotes oxide http://purl.obolibrary.org/obo/CHEBI_25741|http://purl.obolibrary.org/obo/CHEBI_29356
T97 914-917 Chemical denotes Ang http://purl.obolibrary.org/obo/CHEBI_48433
T98 918-920 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T99 971-982 Chemical denotes aldosterone http://purl.obolibrary.org/obo/CHEBI_27584|http://purl.obolibrary.org/obo/CHEBI_30834
T101 1269-1279 Chemical denotes antagonist http://purl.obolibrary.org/obo/CHEBI_48706

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T13 453-467 http://purl.obolibrary.org/obo/GO_0042311 denotes vasodilatative
T14 953-969 http://purl.obolibrary.org/obo/GO_0042310 denotes vasoconstriction
T15 984-996 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T16 1008-1026 http://purl.obolibrary.org/obo/GO_0008283 denotes cell proliferation

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T68 0-122 Sentence denotes ACE and ACE2 are two zinc metalloproteases involved in the biogenesis of the components of renin-angiotensin system (RAS).
T69 123-323 Sentence denotes ACE2 processes angiotensin (Ang) I and II into Ang (1–9) and Ang (1–7), respectively, and it also has other known peptide targets, such as des-Arg(9)-bradykinin, which mediates B1 receptor activation.
T70 324-670 Sentence denotes Ang (1–7) and Ang (1–9) peptides, opposing the effects of ACE/Ang II/Ang II type 1 receptor (AT1R) pathway, are known to mediate vasodilatative (hypotension), antiproliferative and apoptotic effects through Mas and AT2 receptors, respectively, both involving downstream nitric oxide synthase (NOS) pathway activation [38,39,40,41,42,43,44,45,46].
T71 671-826 Sentence denotes Physiology teaches us that there is a range of normality for every biological parameter, below (defect) and above (excess) of which there is a dysfunction.
T72 827-881 Sentence denotes This is likely to be true for ACE as well as for ACE2.
T73 882-1096 Sentence denotes It is well known that excessive Ang II/AT1R pathway activation induces vasoconstriction, aldosterone, inflammation, excessive cell proliferation, thrombosis, cardiac dysfunction and lung alterations (see Figure 1).
T74 1097-1389 Sentence denotes Moreover, most of the experiments show that increased ACE2 activity leads to beneficial effects; however, the experiments were usually performed using models in which its “antagonist“ (ACE) pathway was upregulated or ACE2 itself was downregulated, therefore balancing an unbalanced situation.
T75 1390-1449 Sentence denotes What does it happen in models in which the opposite occurs?

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T16 469-480 Phenotype denotes hypotension http://purl.obolibrary.org/obo/HP_0002615

2_test

Id Subject Object Predicate Lexical cue
32708755-27082314-20678693 642-644 27082314 denotes 38
32708755-29434591-20678694 648-650 29434591 denotes 40
32708755-30554115-20678695 651-653 30554115 denotes 41
32708755-31427727-20678696 654-656 31427727 denotes 42
32708755-20599443-20678697 660-662 20599443 denotes 44
32708755-23249272-20678698 663-665 23249272 denotes 45