PMC:7408073 / 111440-112683 JSONTXT

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LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T228 268-271 Body_part denotes RAS http://purl.obolibrary.org/obo/UBERON_0018229
T229 745-748 Body_part denotes RAS http://purl.obolibrary.org/obo/UBERON_0018229

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
3762 363-367 Gene denotes ACE2 Gene:59272
3763 432-436 Gene denotes ACE2 Gene:59272
3764 564-572 Species denotes patients Tax:9606
3765 121-129 Disease denotes COVID-19 MESH:C000657245
3766 202-210 Disease denotes COVID-19 MESH:C000657245
3767 859-866 Disease denotes failure MESH:D006333

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T606 121-129 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T607 202-210 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T111 170-171 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T112 383-386 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T113 416-424 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T114 593-594 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T115 778-780 http://purl.obolibrary.org/obo/CLO_0050475 denotes my
T116 833-834 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T117 857-858 http://purl.obolibrary.org/obo/CLO_0001020 denotes a

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T12617 268-271 Chemical denotes RAS http://purl.obolibrary.org/obo/CHEBI_63620
T93364 272-282 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T25023 336-340 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T91571 363-377 Chemical denotes ACE2 inhibitor http://purl.obolibrary.org/obo/CHEBI_147289
T70701 368-377 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T14447 462-466 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T92382 680-684 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T52971 745-748 Chemical denotes RAS http://purl.obolibrary.org/obo/CHEBI_63620

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T552 0-130 Sentence denotes At the moment, I am alone in proposing these new and non-conventional therapeutic approaches that may or may not work on COVID-19.
T553 131-316 Sentence denotes In doing so, I have not only described a rationale/strategy to counter COVID-19, but also provided practical information to optimize the RAS inhibitors based on known experimental data.
T554 317-506 Sentence denotes Before any in vivo drug administration (e.g., ACE2 inhibitor), it has to be checked the biological activity (e.g., ACE2) that is affected by the drug, considering the possible side effects.
T555 507-685 Sentence denotes However, this is not always the case and, in some cases, patients are treated without a careful evaluation of the biological parameter that is modulated by the administered drug.
T556 686-898 Sentence denotes In this regard, I have tried to address all aspects of the RAS inhibition in detail because my main concern is that the use of these approaches in a wrong way may lead to a failure or even to deleterious effects.
T557 899-1142 Sentence denotes That is why I have meticulously described all the steps before possible administration and provided the guideline suggestions and specific recommendations in order to increase the probability of success and to minimize the deleterious effects.
T558 1143-1243 Sentence denotes The readers are, however, expected and encouraged to debate and make their own optimized guidelines.