PMC:7408073 / 110116-110512 JSONTXT

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T35","span":{"begin":19,"end":25},"obj":"Body_part"}],"attributes":[{"id":"A35","pred":"fma_id","subj":"T35","obj":"http://purl.org/sig/ont/fma/fma62970"}],"text":"To this regard, if plasma (free) Zn2+ (or total zinc/albumin molar ratio), albumin, IL-10, Ang (1–9), Ang (1–7), Ang (1–5) and/or bradykinin (1–7) will be proven to be reliable surrogate markers for ACE and/or ACE2 enzymatic activity in vivo, they could be exploited, together with circulating ACE and ACE2 activity evaluation, in order to decide who and when to start treating COVID-19 patients."}

{"project":"LitCovid-PubTator","denotations":[{"id":"3733","span":{"begin":75,"end":82},"obj":"Gene"},{"id":"3734","span":{"begin":84,"end":89},"obj":"Gene"},{"id":"3735","span":{"begin":91,"end":99},"obj":"Gene"},{"id":"3736","span":{"begin":113,"end":121},"obj":"Gene"},{"id":"3737","span":{"begin":130,"end":140},"obj":"Gene"},{"id":"3738","span":{"begin":199,"end":202},"obj":"Gene"},{"id":"3739","span":{"begin":210,"end":214},"obj":"Gene"},{"id":"3740","span":{"begin":294,"end":297},"obj":"Gene"},{"id":"3741","span":{"begin":302,"end":306},"obj":"Gene"},{"id":"3743","span":{"begin":102,"end":110},"obj":"Gene"},{"id":"3744","span":{"begin":53,"end":60},"obj":"Gene"},{"id":"3745","span":{"begin":387,"end":395},"obj":"Species"},{"id":"3748","span":{"begin":33,"end":37},"obj":"Chemical"},{"id":"3751","span":{"begin":378,"end":386},"obj":"Disease"}],"attributes":[{"id":"A3733","pred":"tao:has_database_id","subj":"3733","obj":"Gene:213"},{"id":"A3734","pred":"tao:has_database_id","subj":"3734","obj":"Gene:3586"},{"id":"A3735","pred":"tao:has_database_id","subj":"3735","obj":"Gene:284"},{"id":"A3736","pred":"tao:has_database_id","subj":"3736","obj":"Gene:284"},{"id":"A3737","pred":"tao:has_database_id","subj":"3737","obj":"Gene:3827"},{"id":"A3738","pred":"tao:has_database_id","subj":"3738","obj":"Gene:59272"},{"id":"A3739","pred":"tao:has_database_id","subj":"3739","obj":"Gene:59272"},{"id":"A3740","pred":"tao:has_database_id","subj":"3740","obj":"Gene:59272"},{"id":"A3741","pred":"tao:has_database_id","subj":"3741","obj":"Gene:59272"},{"id":"A3743","pred":"tao:has_database_id","subj":"3743","obj":"Gene:284"},{"id":"A3744","pred":"tao:has_database_id","subj":"3744","obj":"Gene:213"},{"id":"A3745","pred":"tao:has_database_id","subj":"3745","obj":"Tax:9606"},{"id":"A3751","pred":"tao:has_database_id","subj":"3751","obj":"MESH:C000657245"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"To this regard, if plasma (free) Zn2+ (or total zinc/albumin molar ratio), albumin, IL-10, Ang (1–9), Ang (1–7), Ang (1–5) and/or bradykinin (1–7) will be proven to be reliable surrogate markers for ACE and/or ACE2 enzymatic activity in vivo, they could be exploited, together with circulating ACE and ACE2 activity evaluation, in order to decide who and when to start treating COVID-19 patients."}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T598","span":{"begin":378,"end":386},"obj":"Disease"}],"attributes":[{"id":"A598","pred":"mondo_id","subj":"T598","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"}],"text":"To this regard, if plasma (free) Zn2+ (or total zinc/albumin molar ratio), albumin, IL-10, Ang (1–9), Ang (1–7), Ang (1–5) and/or bradykinin (1–7) will be proven to be reliable surrogate markers for ACE and/or ACE2 enzymatic activity in vivo, they could be exploited, together with circulating ACE and ACE2 activity evaluation, in order to decide who and when to start treating COVID-19 patients."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T100","span":{"begin":19,"end":25},"obj":"http://purl.obolibrary.org/obo/UBERON_0001969"},{"id":"T101","span":{"begin":225,"end":233},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T102","span":{"begin":307,"end":315},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"}],"text":"To this regard, if plasma (free) Zn2+ (or total zinc/albumin molar ratio), albumin, IL-10, Ang (1–9), Ang (1–7), Ang (1–5) and/or bradykinin (1–7) will be proven to be reliable surrogate markers for ACE and/or ACE2 enzymatic activity in vivo, they could be exploited, together with circulating ACE and ACE2 activity evaluation, in order to decide who and when to start treating COVID-19 patients."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T62900","span":{"begin":33,"end":36},"obj":"Chemical"},{"id":"T20847","span":{"begin":48,"end":52},"obj":"Chemical"},{"id":"T4937","span":{"begin":84,"end":86},"obj":"Chemical"},{"id":"T2350","span":{"begin":130,"end":140},"obj":"Chemical"}],"attributes":[{"id":"A81070","pred":"chebi_id","subj":"T62900","obj":"http://purl.obolibrary.org/obo/CHEBI_37256"},{"id":"A90703","pred":"chebi_id","subj":"T20847","obj":"http://purl.obolibrary.org/obo/CHEBI_27363"},{"id":"A73614","pred":"chebi_id","subj":"T20847","obj":"http://purl.obolibrary.org/obo/CHEBI_30185"},{"id":"A36428","pred":"chebi_id","subj":"T4937","obj":"http://purl.obolibrary.org/obo/CHEBI_63895"},{"id":"A13554","pred":"chebi_id","subj":"T4937","obj":"http://purl.obolibrary.org/obo/CHEBI_74072"},{"id":"A61174","pred":"chebi_id","subj":"T2350","obj":"http://purl.obolibrary.org/obo/CHEBI_3165"}],"text":"To this regard, if plasma (free) Zn2+ (or total zinc/albumin molar ratio), albumin, IL-10, Ang (1–9), Ang (1–7), Ang (1–5) and/or bradykinin (1–7) will be proven to be reliable surrogate markers for ACE and/or ACE2 enzymatic activity in vivo, they could be exploited, together with circulating ACE and ACE2 activity evaluation, in order to decide who and when to start treating COVID-19 patients."}

{"project":"LitCovid-sentences","denotations":[{"id":"T548","span":{"begin":0,"end":396},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"To this regard, if plasma (free) Zn2+ (or total zinc/albumin molar ratio), albumin, IL-10, Ang (1–9), Ang (1–7), Ang (1–5) and/or bradykinin (1–7) will be proven to be reliable surrogate markers for ACE and/or ACE2 enzymatic activity in vivo, they could be exploited, together with circulating ACE and ACE2 activity evaluation, in order to decide who and when to start treating COVID-19 patients."}