PMC:7408073 / 109809-111439 JSONTXT

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LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T35 326-332 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T36 1114-1119 Body_part denotes blood http://purl.org/sig/ont/fma/fma9670
T37 1130-1140 Body_part denotes eosinophil http://purl.org/sig/ont/fma/fma62861
T38 1298-1314 Body_part denotes epithelial cells http://purl.org/sig/ont/fma/fma66768
T39 1309-1314 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T226 1114-1119 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T227 1181-1184 Body_part denotes RAS http://purl.obolibrary.org/obo/UBERON_0018229

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
3733 382-389 Gene denotes albumin Gene:213
3734 391-396 Gene denotes IL-10 Gene:3586
3735 398-406 Gene denotes Ang (1–9 Gene:284
3736 420-428 Gene denotes Ang (1–5 Gene:284
3737 437-447 Gene denotes bradykinin Gene:3827
3738 506-509 Gene denotes ACE Gene:59272
3739 517-521 Gene denotes ACE2 Gene:59272
3740 601-604 Gene denotes ACE Gene:59272
3741 609-613 Gene denotes ACE2 Gene:59272
3742 1348-1352 Gene denotes ACE2 Gene:59272
3743 409-417 Gene denotes Ang (1–7 Gene:284
3744 360-367 Gene denotes albumin Gene:213
3745 694-702 Species denotes patients Tax:9606
3746 845-853 Species denotes patients Tax:9606
3747 1053-1060 Species denotes patient Tax:9606
3748 340-344 Chemical denotes Zn2+
3749 102-114 Disease denotes dysfunctions MESH:D009461
3750 251-259 Disease denotes COVID-19 MESH:C000657245
3751 685-693 Disease denotes COVID-19 MESH:C000657245
3752 719-747 Disease denotes eosinopaenia and hypotension MESH:D007022
3753 1215-1227 Disease denotes inflammation MESH:D007249
3754 1428-1448 Disease denotes SARS-CoV-2 infection MESH:C000657245
3755 1521-1529 Disease denotes COVID-19 MESH:C000657245

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T597 251-259 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T598 685-693 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T599 736-747 Disease denotes hypotension http://purl.obolibrary.org/obo/MONDO_0005468
T600 1215-1227 Disease denotes inflammation http://purl.obolibrary.org/obo/MONDO_0021166
T601 1428-1436 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T602 1428-1432 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T603 1439-1448 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T604 1521-1529 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T605 1590-1593 Disease denotes flu http://purl.obolibrary.org/obo/MONDO_0005812

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T100 326-332 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T101 532-540 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T102 614-622 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T103 1114-1119 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T104 1114-1119 http://www.ebi.ac.uk/efo/EFO_0000296 denotes blood
T105 1185-1193 http://purl.obolibrary.org/obo/PR_000018263 denotes peptides
T106 1234-1237 http://purl.obolibrary.org/obo/PR_000001343 denotes aim
T107 1298-1308 http://purl.obolibrary.org/obo/CL_0000066 denotes epithelial
T108 1309-1314 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T109 1581-1582 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T110 1595-1596 http://purl.obolibrary.org/obo/CLO_0001020 denotes a

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T62900 340-343 Chemical denotes Zn2 http://purl.obolibrary.org/obo/CHEBI_37256
T20847 355-359 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T4937 391-393 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T2350 437-447 Chemical denotes bradykinin http://purl.obolibrary.org/obo/CHEBI_3165
T24872 1181-1184 Chemical denotes RAS http://purl.obolibrary.org/obo/CHEBI_63620
T53946 1185-1193 Chemical denotes peptides http://purl.obolibrary.org/obo/CHEBI_16670

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T11 1215-1227 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T546 0-192 Sentence denotes In order to decide who to treat, and when to start treatment, it is important to define the entity of dysfunctions, probability of treatment success and probability to develop adverse effects.
T547 193-306 Sentence denotes To promptly intervene in order to prevent severe forms of COVID-19, we need early markers of disease progression.
T548 307-703 Sentence denotes To this regard, if plasma (free) Zn2+ (or total zinc/albumin molar ratio), albumin, IL-10, Ang (1–9), Ang (1–7), Ang (1–5) and/or bradykinin (1–7) will be proven to be reliable surrogate markers for ACE and/or ACE2 enzymatic activity in vivo, they could be exploited, together with circulating ACE and ACE2 activity evaluation, in order to decide who and when to start treating COVID-19 patients.
T549 704-802 Sentence denotes Alternatively, eosinopaenia and hypotension may be also exploited as signs of disease progression.
T550 803-1229 Sentence denotes In any case, since the conditions of some patients can be critical, it is highly recommended to administer the minimal effective dose in order to reduce possible side effects, starting with low and increasing doses, while at the same time monitoring patient status and early signs of disease progression (e.g., blood pressure, eosinophil counts, molecular concentrations of the RAS peptides and other markers of inflammation).
T551 1230-1630 Sentence denotes The aim of the project was not necessarily to stop viral entry (the epithelial cells take already care of it shedding ACE2) but to block positive feedback loops that follow the cellular response to SARS-CoV-2 infection, which are likely the main cause of the severe symptoms associated with COVID-19, doing so, the disease might hopefully become like a simple flu, a spontaneously eradicable disease.

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T173 736-747 Phenotype denotes hypotension http://purl.obolibrary.org/obo/HP_0002615