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PMC:7408073 / 10894-13772 JSONTXT

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LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T74 198-205 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T75 336-344 Body_part denotes cytokine http://purl.org/sig/ont/fma/fma84050
T76 410-418 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T77 790-795 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T78 945-951 Body_part denotes sputum http://purl.org/sig/ont/fma/fma312401
T79 1040-1046 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T80 1053-1056 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T81 1118-1129 Body_part denotes lymphocytes http://purl.org/sig/ont/fma/fma62863
T82 1147-1150 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T83 1183-1186 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T84 1192-1198 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T85 1214-1217 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T86 1315-1321 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T87 1569-1575 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T88 1576-1579 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T89 1909-1913 Body_part denotes hand http://purl.org/sig/ont/fma/fma9712
T90 2298-2306 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T91 2368-2375 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T92 2448-2456 Body_part denotes antibody http://purl.org/sig/ont/fma/fma62871
T93 2757-2763 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T19 775-781 Body_part denotes organs http://purl.obolibrary.org/obo/UBERON_0000062
T20 945-951 Body_part denotes sputum http://purl.obolibrary.org/obo/UBERON_0007311
T21 1909-1913 Body_part denotes hand http://purl.obolibrary.org/obo/UBERON_0002398

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
437 133-137 Gene denotes ACE2 Gene:59272
438 294-298 Gene denotes ACE2 Gene:59272
439 405-409 Gene denotes ACE2 Gene:59272
440 807-811 Gene denotes ACE2 Gene:59272
441 1713-1717 Gene denotes ACE2 Gene:59272
442 2174-2178 Gene denotes ACE2 Gene:59272
443 2362-2367 Gene denotes spike Gene:43740568
444 2292-2297 Gene denotes spike Gene:43740568
445 123-128 Gene denotes spike Gene:43740568
446 111-119 Species denotes patients Tax:9606
447 471-481 Species denotes SARS-CoV-2 Tax:2697049
448 539-549 Species denotes SARS-CoV-2 Tax:2697049
449 643-653 Species denotes SARS-CoV-2 Tax:2697049
450 961-969 Species denotes SARS-CoV Tax:694009
451 970-978 Species denotes patients Tax:9606
452 1174-1182 Species denotes SARS-CoV Tax:694009
453 1260-1268 Species denotes patients Tax:9606
454 1336-1344 Species denotes patients Tax:9606
455 1524-1532 Species denotes patients Tax:9606
456 1613-1621 Species denotes patients Tax:9606
457 1684-1692 Species denotes children Tax:9606
458 2080-2090 Species denotes SARS-CoV-2 Tax:2697049
459 2245-2255 Species denotes SARS-CoV-2 Tax:2697049
460 2571-2584 Species denotes coronaviruses Tax:11118
461 93-101 Disease denotes COVID-19 MESH:C000657245
462 102-110 Disease denotes infected MESH:D007239
463 1327-1335 Disease denotes COVID-19 MESH:C000657245
464 1413-1421 Disease denotes COVID-19 MESH:C000657245
465 1496-1513 Disease denotes SARS-CoV infected MESH:C000657245
466 1749-1765 Disease denotes Kawasaki disease MESH:D009080
467 2614-2623 Disease denotes infection MESH:D007239
468 2769-2777 Disease denotes COVID-19 MESH:C000657245
469 2849-2857 Disease denotes COVID-19 MESH:C000657245

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T98 93-101 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T99 471-479 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T100 471-475 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T101 539-547 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T102 539-543 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T103 643-651 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T104 643-647 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T105 961-969 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T106 961-965 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T107 1174-1182 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T108 1174-1178 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T109 1327-1335 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T110 1413-1421 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T111 1496-1504 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T112 1496-1500 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T113 1749-1765 Disease denotes Kawasaki disease http://purl.obolibrary.org/obo/MONDO_0012727
T114 2080-2088 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T115 2080-2084 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T116 2245-2253 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T117 2245-2249 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T118 2614-2623 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T119 2769-2777 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T120 2849-2857 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T72343 8-10 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T25654 33-35 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T15557 230-235 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T67356 244-247 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T824 345-355 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T96980 454-456 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T60119 526-528 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T36399 584-590 http://purl.obolibrary.org/obo/CLO_0001658 denotes active
T97656 729-737 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T10969 775-781 http://purl.obolibrary.org/obo/UBERON_0003103 denotes organs
T24009 790-795 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T60151 829-837 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T130 1040-1046 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T131 1192-1198 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T132 1315-1321 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T133 1569-1575 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T134 1639-1640 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T135 1782-1784 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T136 1804-1805 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T137 1851-1853 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T138 1921-1923 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T139 1942-1944 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T140 2032-2034 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T141 2070-2072 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T142 2198-2200 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T143 2388-2390 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T144 2477-2478 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T145 2513-2522 http://purl.obolibrary.org/obo/OBI_0000245 denotes organized
T146 2589-2594 http://www.ebi.ac.uk/efo/EFO_0001410 denotes armed
T147 2757-2763 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T148 2798-2799 http://purl.obolibrary.org/obo/CLO_0001020 denotes a

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T69 198-205 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T70 410-418 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T71 2298-2306 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T72 2368-2375 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T58005 299-312 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T37916 865-872 http://purl.obolibrary.org/obo/GO_0009606 denotes tropism
T72358 1657-1664 http://purl.obolibrary.org/obo/GO_0009606 denotes tropism
T98067 2648-2664 http://purl.obolibrary.org/obo/GO_0006955 denotes immune responses

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T54 0-157 Sentence denotes Several S1-sACE2 complexes, free S1 fragments or sACE2 are likely released in bloodstream of COVID-19 infected patients by spike and ACE2 receptor cleavages.
T55 158-633 Sentence denotes As already mentioned, circulating sACE2 protein shedding independent on virus contact has been also described either spontaneously when ACE2 transcription is upregulated or upon cytokine activation; it is therefore likely that in the bloodstreams ACE2 proteins are available to bind to both free S1 fragments and SARS-CoV-2 particles, finally leading to more and more S1-sACE2 and SARS-CoV-2-sACE2 complexes bearing enzymatic active sACE2 (see Figure later in the Section 4).
T56 634-909 Sentence denotes Of note, SARS-CoV-2-sACE2 complexes, sequestrating sACE2, can drive part of the sACE2 systemic activity and concentrate it locally where the organs possess cells expressing ACE2 on their surface membrane, i.e., following the viral tropism (see Figure later in the Section 4).
T57 910-1204 Sentence denotes Indeed, although the viral load in sputum of adult SARS-CoV patients was usually higher than 104 copies/mL, reports indicate that plasma viral RNA concentrations are low, usually lower than 190 copies/mL and lymphocytes have much higher RNA-copy concentrations of SARS-CoV RNA than plasma [30].
T58 1205-1350 Sentence denotes Very low RNA concentrations with no difference between patients with mild or severe symptoms were detected in plasma from COVID-19 patients [30].
T59 1351-1482 Sentence denotes The viral load in nasal swabs of asymptomatic and symptomatic COVID-19-positive subjects was also not significantly different [31].
T60 1483-1767 Sentence denotes Of interest, SARS-CoV infected pediatric patients have more than double the amount of plasma RNA copies/mL when compared to adult patients [30], suggesting a different viral tropism between adults and children (different cellular ACE2 expression possibly leading to Kawasaki disease).
T61 1768-1895 Sentence denotes Notably, free S1 fragments may have a decoy function for autologous/exogenous anti-S1-receptor binding domain (RBD) antibodies.
T62 1896-2126 Sentence denotes On the other hand, sACE2-S1 complexes masking S1-RBD might also impair either generation of autologous high affinity antibodies against S1-RBD or recognition/inactivation of S1-RBD on SARS-CoV-2 by autologous/exogenous antibodies.
T63 2127-2499 Sentence denotes Therefore, antibodies that do not compete with ACE2 for the binding to S1-RBD might be more effective in neutralizing SARS-CoV-2 [32,33], knowing that the number of spike proteins per virion is estimated to be around 70 and that every spike protein bears three S1 receptor binding domains, which are masked to autologous antibody recognition when in a “down” conformation.
T64 2500-2695 Sentence denotes These highly organized molecular features clearly demonstrate that the coronaviruses are armed with sophisticated infection machinery able to evade immune responses induced or not by vaccination.
T65 2696-2878 Sentence denotes Nevertheless, passive immunotherapy by means of convalescent plasma from COVID-19 recovered donors is a promising option for prevention and treatment of COVID-19 [32,33,34,35,36,37].

2_test

Id Subject Object Predicate Lexical cue
32708755-32107119-20678683 1200-1202 32107119 denotes 30
32708755-32107119-20678684 1346-1348 32107119 denotes 30
32708755-32107119-20678685 1623-1625 32107119 denotes 30
32708755-32065055-20678686 2257-2259 32065055 denotes 32
32708755-32366817-20678687 2260-2262 32366817 denotes 33
32708755-32065055-20678688 2859-2861 32065055 denotes 32
32708755-32366817-20678689 2862-2864 32366817 denotes 33
32708755-32404477-20678690 2865-2867 32404477 denotes 34
32708755-32253318-20678691 2871-2873 32253318 denotes 36
32708755-32243945-20678692 2874-2876 32243945 denotes 37