PMC:7408073 / 104683-106651 JSONTXT

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LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T23 249-261 Body_part denotes cell surface http://purl.org/sig/ont/fma/fma67653
T24 249-253 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T25 998-1006 Body_part denotes cytokine http://purl.org/sig/ont/fma/fma84050
T26 1094-1109 Body_part denotes coronary artery http://purl.org/sig/ont/fma/fma49893
T27 1331-1336 Body_part denotes heart http://purl.org/sig/ont/fma/fma7088

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T216 434-437 Body_part denotes RAS http://purl.obolibrary.org/obo/UBERON_0018229
T217 793-796 Body_part denotes RAS http://purl.obolibrary.org/obo/UBERON_0018229
T218 1094-1109 Body_part denotes coronary artery http://purl.obolibrary.org/obo/UBERON_0001621
T219 1103-1109 Body_part denotes artery http://purl.obolibrary.org/obo/UBERON_0001637
T220 1172-1175 Body_part denotes RAS http://purl.obolibrary.org/obo/UBERON_0018229
T221 1331-1336 Body_part denotes heart http://purl.obolibrary.org/obo/UBERON_0000948

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
3623 146-150 Gene denotes ACE2 Gene:59272
3624 155-158 Gene denotes ACE Gene:59272
3625 186-190 Gene denotes ACE2 Gene:59272
3626 196-199 Gene denotes ACE Gene:59272
3627 1568-1571 Gene denotes ACE Gene:59272
3628 1576-1580 Gene denotes ACE2 Gene:59272
3629 479-484 Gene denotes renin Gene:5972
3630 969-977 Gene denotes Ang-(1–7 Gene:284
3631 1035-1043 Species denotes patients Tax:9606
3632 1549-1557 Species denotes patients Tax:9606
3633 1309-1318 Chemical denotes CaNa2EDTA
3634 96-109 Disease denotes hyperactivity MESH:D006948
3635 345-365 Disease denotes SARS-CoV-2 infection MESH:C000657245
3636 408-415 Disease denotes hypoxia MESH:D000860
3637 644-652 Disease denotes COVID-19 MESH:C000657245
3638 719-739 Disease denotes SARS-CoV-2 infection MESH:C000657245
3639 862-866 Disease denotes ARDS MESH:D012128
3640 916-923 Disease denotes hypoxia MESH:D000860
3641 928-943 Disease denotes cardiac failure MESH:D006333
3642 1058-1062 Disease denotes ARDS MESH:D012128
3643 1094-1117 Disease denotes coronary artery disease MESH:D003324
3644 1228-1240 Disease denotes dysfunctions MESH:D009461
3645 1322-1344 Disease denotes coronary heart disease MESH:D003324

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T572 345-353 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T573 345-349 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T574 356-365 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T575 644-652 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T576 719-727 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T577 719-723 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T578 730-739 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T579 862-866 Disease denotes ARDS http://purl.obolibrary.org/obo/MONDO_0006502
T580 868-871 Disease denotes PAH http://purl.obolibrary.org/obo/MONDO_0015924
T581 928-943 Disease denotes cardiac failure http://purl.obolibrary.org/obo/MONDO_0005252
T582 1058-1062 Disease denotes ARDS http://purl.obolibrary.org/obo/MONDO_0006502
T583 1067-1070 Disease denotes PAH http://purl.obolibrary.org/obo/MONDO_0015924
T584 1094-1117 Disease denotes coronary artery disease http://purl.obolibrary.org/obo/MONDO_0005010
T585 1103-1117 Disease denotes artery disease http://purl.obolibrary.org/obo/MONDO_0000473
T586 1322-1344 Disease denotes coronary heart disease http://purl.obolibrary.org/obo/MONDO_0005010
T587 1331-1344 Disease denotes heart disease http://purl.obolibrary.org/obo/MONDO_0005267

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T60 211-219 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T61 249-253 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T62 422-426 http://www.ebi.ac.uk/efo/EFO_0001410 denotes arms
T63 781-785 http://www.ebi.ac.uk/efo/EFO_0001410 denotes arms
T64 996-997 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T65 1103-1109 http://purl.obolibrary.org/obo/UBERON_0001637 denotes artery
T66 1103-1109 http://www.ebi.ac.uk/efo/EFO_0000814 denotes artery
T67 1160-1164 http://www.ebi.ac.uk/efo/EFO_0001410 denotes arms
T68 1251-1252 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T69 1331-1336 http://purl.obolibrary.org/obo/UBERON_0000948 denotes heart
T70 1331-1336 http://purl.obolibrary.org/obo/UBERON_0007100 denotes heart
T71 1331-1336 http://purl.obolibrary.org/obo/UBERON_0015228 denotes heart
T72 1331-1336 http://www.ebi.ac.uk/efo/EFO_0000815 denotes heart
T73 1657-1667 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T74 1908-1909 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T75 1932-1933 http://purl.obolibrary.org/obo/CLO_0001020 denotes a

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T78307 22-38 Chemical denotes chelating agents http://purl.obolibrary.org/obo/CHEBI_38161
T50244 52-56 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T86055 298-314 Chemical denotes chelating agents http://purl.obolibrary.org/obo/CHEBI_38161
T24696 434-437 Chemical denotes RAS http://purl.obolibrary.org/obo/CHEBI_63620
T59302 485-495 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T40754 502-518 Chemical denotes chelating agents http://purl.obolibrary.org/obo/CHEBI_38161
T43600 566-571 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T37560 680-685 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T45827 793-796 Chemical denotes RAS http://purl.obolibrary.org/obo/CHEBI_63620
T9258 868-871 Chemical denotes PAH http://purl.obolibrary.org/obo/CHEBI_104011|http://purl.obolibrary.org/obo/CHEBI_31204|http://purl.obolibrary.org/obo/CHEBI_33848|http://purl.obolibrary.org/obo/CHEBI_53305
T27101 962-964 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T63845 1067-1070 Chemical denotes PAH http://purl.obolibrary.org/obo/CHEBI_104011|http://purl.obolibrary.org/obo/CHEBI_31204|http://purl.obolibrary.org/obo/CHEBI_33848|http://purl.obolibrary.org/obo/CHEBI_53305
T5467 1172-1175 Chemical denotes RAS http://purl.obolibrary.org/obo/CHEBI_63620
T76100 1944-1952 Chemical denotes medicine http://purl.obolibrary.org/obo/CHEBI_23888

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T5 111-120 http://purl.obolibrary.org/obo/GO_0009058 denotes synthesis

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T516 0-278 Sentence denotes As already mentioned, chelating agents, by limiting zinc cellular availability, might influence hyperactivity, synthesis and conformation of both ACE2 and ACE, which may impair not only ACE2 (and ACE) enzymatic activity but also its availability on cell surface for viral entry.
T517 279-461 Sentence denotes For these reasons, chelating agents might be effective to counter SARS-CoV-2 infection, and in particular when (e.g., induced by hypoxia) both arms of the RAS are likely upregulated.
T518 462-653 Sentence denotes Differently from renin inhibitors, more chelating agents are commercially available and both classes of drugs might be administered, alone or in combination with other therapies for COVID-19.
T519 654-944 Sentence denotes Of note, these classes of drugs might be beneficial not only for SARS-CoV-2 infection but also for other disease in which both arms of the RAS (and of the inflammatory system) are upregulated, as for example ARDS, PAH and other pathologies associated to chronic hypoxia and cardiac failure.
T520 945-1241 Sentence denotes Indeed, both Ang-II and Ang-(1–7) upregulation and a cytokine storm are common aspects in patients not only with ARDS and PAH but also with critical coronary artery disease [182], suggesting an upregulation of both arms of the RAS and of the inflammatory system in several different dysfunctions.
T521 1242-1345 Sentence denotes Notably, a number of clinical trials have indicated the utility of CaNa2EDTA in coronary heart disease.
T522 1346-1465 Sentence denotes It was believed that chelation therapy might alter plaque morphology and volume, or improve endothelial function [123].
T523 1466-1513 Sentence denotes However, the evidence was not convincing [123].
T524 1514-1619 Sentence denotes Future clinical trials on selected patients with both ACE and ACE2 upregulation might be more convincing.
T525 1620-1749 Sentence denotes It is clear that similar pathways of activation can lead to different outcomes depending on individual predisposition/background.
T526 1750-1968 Sentence denotes Therefore, future efforts to understand the genetic, morpho-physiological, environmental and lifestyle factors that individually affect the predisposition to a specific disease with a precision medicine must be pursed.

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T168 96-109 Phenotype denotes hyperactivity http://purl.obolibrary.org/obo/HP_0000752
T169 408-415 Phenotype denotes hypoxia http://purl.obolibrary.org/obo/HP_0012418
T170 916-923 Phenotype denotes hypoxia http://purl.obolibrary.org/obo/HP_0012418
T171 928-943 Phenotype denotes cardiac failure http://purl.obolibrary.org/obo/HP_0001635
T172 998-1012 Phenotype denotes cytokine storm http://purl.obolibrary.org/obo/HP_0033041

2_test

Id Subject Object Predicate Lexical cue
32708755-27432541-20679037 1119-1122 27432541 denotes 182
32708755-20717537-20679038 1460-1463 20717537 denotes 123
32708755-20717537-20679039 1508-1511 20717537 denotes 123