PMC:7408073 / 104650-109175 JSONTXT

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LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T23 282-294 Body_part denotes cell surface http://purl.org/sig/ont/fma/fma67653
T24 282-286 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T25 1031-1039 Body_part denotes cytokine http://purl.org/sig/ont/fma/fma84050
T26 1127-1142 Body_part denotes coronary artery http://purl.org/sig/ont/fma/fma49893
T27 1364-1369 Body_part denotes heart http://purl.org/sig/ont/fma/fma7088
T28 2210-2232 Body_part denotes gastrointestinal tract http://purl.org/sig/ont/fma/fma71132
T29 2427-2433 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T30 2460-2470 Body_part denotes intestinal http://purl.org/sig/ont/fma/fma7199
T31 3184-3189 Body_part denotes blood http://purl.org/sig/ont/fma/fma9670
T32 3557-3561 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T33 3562-3568 Body_part denotes tissue http://purl.org/sig/ont/fma/fma9637

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T216 467-470 Body_part denotes RAS http://purl.obolibrary.org/obo/UBERON_0018229
T217 826-829 Body_part denotes RAS http://purl.obolibrary.org/obo/UBERON_0018229
T218 1127-1142 Body_part denotes coronary artery http://purl.obolibrary.org/obo/UBERON_0001621
T219 1136-1142 Body_part denotes artery http://purl.obolibrary.org/obo/UBERON_0001637
T220 1205-1208 Body_part denotes RAS http://purl.obolibrary.org/obo/UBERON_0018229
T221 1364-1369 Body_part denotes heart http://purl.obolibrary.org/obo/UBERON_0000948
T222 3184-3189 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T223 3557-3561 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T224 3562-3568 Body_part denotes tissue http://purl.obolibrary.org/obo/UBERON_0000479

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
3599 23-32 Chemical denotes CaNa2EDTA
3623 179-183 Gene denotes ACE2 Gene:59272
3624 188-191 Gene denotes ACE Gene:59272
3625 219-223 Gene denotes ACE2 Gene:59272
3626 229-232 Gene denotes ACE Gene:59272
3627 1601-1604 Gene denotes ACE Gene:59272
3628 1609-1613 Gene denotes ACE2 Gene:59272
3629 512-517 Gene denotes renin Gene:5972
3630 1002-1010 Gene denotes Ang-(1–7 Gene:284
3631 1068-1076 Species denotes patients Tax:9606
3632 1582-1590 Species denotes patients Tax:9606
3633 1342-1351 Chemical denotes CaNa2EDTA
3634 129-142 Disease denotes hyperactivity MESH:D006948
3635 378-398 Disease denotes SARS-CoV-2 infection MESH:C000657245
3636 441-448 Disease denotes hypoxia MESH:D000860
3637 677-685 Disease denotes COVID-19 MESH:C000657245
3638 752-772 Disease denotes SARS-CoV-2 infection MESH:C000657245
3639 895-899 Disease denotes ARDS MESH:D012128
3640 949-956 Disease denotes hypoxia MESH:D000860
3641 961-976 Disease denotes cardiac failure MESH:D006333
3642 1091-1095 Disease denotes ARDS MESH:D012128
3643 1127-1150 Disease denotes coronary artery disease MESH:D003324
3644 1261-1273 Disease denotes dysfunctions MESH:D009461
3645 1355-1377 Disease denotes coronary heart disease MESH:D003324
3669 2580-2583 Species denotes men Tax:9606
3670 3161-3169 Species denotes patients Tax:9606
3671 4415-4422 Species denotes patient Tax:9606
3672 2036-2043 Chemical denotes calcium MESH:D002118
3673 2052-2061 Chemical denotes CaNa2EDTA
3674 2174-2183 Chemical denotes CaNa2EDTA
3675 2389-2398 Chemical denotes CaNa2EDTA
3676 2654-2663 Chemical denotes CaNa2EDTA
3677 2696-2705 Chemical denotes CaNa2EDTA
3678 2917-2926 Chemical denotes CaNa2EDTA
3679 3021-3030 Chemical denotes CaNa2EDTA
3680 3243-3252 Chemical denotes CaNa2EDTA
3681 3447-3456 Chemical denotes CaNa2EDTA
3682 3529-3534 Chemical denotes metal MESH:D008670
3683 3649-3653 Chemical denotes EDTA MESH:D004492
3684 3939-3948 Chemical denotes CaNa2EDTA
3685 4219-4228 Chemical denotes CaNa2EDTA
3686 2120-2129 Disease denotes poisoning MESH:D011041
3687 3052-3061 Disease denotes poisoning MESH:D011041
3688 3420-3427 Disease denotes painful MESH:D010146
3689 4261-4269 Disease denotes COVID-19 MESH:C000657245
3690 4376-4384 Disease denotes COVID-19 MESH:C000657245
3691 4494-4502 Disease denotes toxicity MESH:D064420

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T572 378-386 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T573 378-382 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T574 389-398 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T575 677-685 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T576 752-760 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T577 752-756 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T578 763-772 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T579 895-899 Disease denotes ARDS http://purl.obolibrary.org/obo/MONDO_0006502
T580 901-904 Disease denotes PAH http://purl.obolibrary.org/obo/MONDO_0015924
T581 961-976 Disease denotes cardiac failure http://purl.obolibrary.org/obo/MONDO_0005252
T582 1091-1095 Disease denotes ARDS http://purl.obolibrary.org/obo/MONDO_0006502
T583 1100-1103 Disease denotes PAH http://purl.obolibrary.org/obo/MONDO_0015924
T584 1127-1150 Disease denotes coronary artery disease http://purl.obolibrary.org/obo/MONDO_0005010
T585 1136-1150 Disease denotes artery disease http://purl.obolibrary.org/obo/MONDO_0000473
T586 1355-1377 Disease denotes coronary heart disease http://purl.obolibrary.org/obo/MONDO_0005010
T587 1364-1377 Disease denotes heart disease http://purl.obolibrary.org/obo/MONDO_0005267
T588 2115-2129 Disease denotes lead poisoning http://purl.obolibrary.org/obo/MONDO_0018019
T589 2120-2129 Disease denotes poisoning http://purl.obolibrary.org/obo/MONDO_0029000
T590 3047-3061 Disease denotes lead poisoning http://purl.obolibrary.org/obo/MONDO_0018019
T591 3052-3061 Disease denotes poisoning http://purl.obolibrary.org/obo/MONDO_0029000
T592 3535-3545 Disease denotes poisonings http://purl.obolibrary.org/obo/MONDO_0029000
T593 4261-4269 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T594 4376-4384 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T60 244-252 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T61 282-286 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T62 455-459 http://www.ebi.ac.uk/efo/EFO_0001410 denotes arms
T63 814-818 http://www.ebi.ac.uk/efo/EFO_0001410 denotes arms
T64 1029-1030 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T65 1136-1142 http://purl.obolibrary.org/obo/UBERON_0001637 denotes artery
T66 1136-1142 http://www.ebi.ac.uk/efo/EFO_0000814 denotes artery
T67 1193-1197 http://www.ebi.ac.uk/efo/EFO_0001410 denotes arms
T68 1284-1285 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T69 1364-1369 http://purl.obolibrary.org/obo/UBERON_0000948 denotes heart
T70 1364-1369 http://purl.obolibrary.org/obo/UBERON_0007100 denotes heart
T71 1364-1369 http://purl.obolibrary.org/obo/UBERON_0015228 denotes heart
T72 1364-1369 http://www.ebi.ac.uk/efo/EFO_0000815 denotes heart
T73 1690-1700 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T74 1941-1942 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T75 1965-1966 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T76 2210-2232 http://purl.obolibrary.org/obo/UBERON_0005409 denotes gastrointestinal tract
T77 2427-2433 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T78 2460-2470 http://purl.obolibrary.org/obo/UBERON_0000160 denotes intestinal
T79 2460-2470 http://www.ebi.ac.uk/efo/EFO_0000834 denotes intestinal
T80 2537-2545 http://purl.obolibrary.org/obo/OBI_0100026 denotes organism
T81 2537-2545 http://purl.obolibrary.org/obo/UBERON_0000468 denotes organism
T82 2632-2633 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T83 2713-2714 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T84 3184-3189 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T85 3184-3189 http://www.ebi.ac.uk/efo/EFO_0000296 denotes blood
T86 3210-3214 http://purl.obolibrary.org/obo/CLO_0003535 denotes g/m2
T87 3345-3346 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T88 3471-3474 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T89 3557-3561 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T90 3557-3561 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T91 4103-4106 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T92 4107-4108 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T93 4405-4406 http://purl.obolibrary.org/obo/CLO_0001020 denotes a

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T78307 55-71 Chemical denotes chelating agents http://purl.obolibrary.org/obo/CHEBI_38161
T50244 85-89 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T86055 331-347 Chemical denotes chelating agents http://purl.obolibrary.org/obo/CHEBI_38161
T24696 467-470 Chemical denotes RAS http://purl.obolibrary.org/obo/CHEBI_63620
T59302 518-528 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T40754 535-551 Chemical denotes chelating agents http://purl.obolibrary.org/obo/CHEBI_38161
T43600 599-604 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T37560 713-718 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T45827 826-829 Chemical denotes RAS http://purl.obolibrary.org/obo/CHEBI_63620
T9258 901-904 Chemical denotes PAH http://purl.obolibrary.org/obo/CHEBI_104011|http://purl.obolibrary.org/obo/CHEBI_31204|http://purl.obolibrary.org/obo/CHEBI_33848|http://purl.obolibrary.org/obo/CHEBI_53305
T27101 995-997 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T63845 1100-1103 Chemical denotes PAH http://purl.obolibrary.org/obo/CHEBI_104011|http://purl.obolibrary.org/obo/CHEBI_31204|http://purl.obolibrary.org/obo/CHEBI_33848|http://purl.obolibrary.org/obo/CHEBI_53305
T5467 1205-1208 Chemical denotes RAS http://purl.obolibrary.org/obo/CHEBI_63620
T76100 1977-1985 Chemical denotes medicine http://purl.obolibrary.org/obo/CHEBI_23888
T57881 2036-2043 Chemical denotes calcium http://purl.obolibrary.org/obo/CHEBI_22984|http://purl.obolibrary.org/obo/CHEBI_29320
T83360 2102-2110 Chemical denotes antidote http://purl.obolibrary.org/obo/CHEBI_50247
T37122 2153-2157 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T27252 2158-2166 Chemical denotes chelator http://purl.obolibrary.org/obo/CHEBI_38161
T65049 2434-2438 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T28613 2471-2475 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T82046 2518-2522 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T31373 2792-2796 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T61878 3649-3653 Chemical denotes EDTA http://purl.obolibrary.org/obo/CHEBI_42191|http://purl.obolibrary.org/obo/CHEBI_64755
T17876 3788-3804 Chemical denotes chelating agents http://purl.obolibrary.org/obo/CHEBI_38161
T48035 4094-4102 Chemical denotes chelator http://purl.obolibrary.org/obo/CHEBI_38161

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T5 144-153 http://purl.obolibrary.org/obo/GO_0009058 denotes synthesis
T6 2518-2529 http://purl.obolibrary.org/obo/GO_0071578 denotes zinc uptake
T7 2523-2529 http://purl.obolibrary.org/obo/GO_0098739 denotes uptake
T8 2523-2529 http://purl.obolibrary.org/obo/GO_0098657 denotes uptake
T9 2728-2737 http://purl.obolibrary.org/obo/GO_0007588 denotes excretion
T10 4067-4088 http://purl.obolibrary.org/obo/GO_0003094 denotes glomerular filtration

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T513 0-4 Sentence denotes 8.3.
T514 5-22 Sentence denotes Chelating Agents:
T515 23-32 Sentence denotes CaNa2EDTA
T516 33-311 Sentence denotes As already mentioned, chelating agents, by limiting zinc cellular availability, might influence hyperactivity, synthesis and conformation of both ACE2 and ACE, which may impair not only ACE2 (and ACE) enzymatic activity but also its availability on cell surface for viral entry.
T517 312-494 Sentence denotes For these reasons, chelating agents might be effective to counter SARS-CoV-2 infection, and in particular when (e.g., induced by hypoxia) both arms of the RAS are likely upregulated.
T518 495-686 Sentence denotes Differently from renin inhibitors, more chelating agents are commercially available and both classes of drugs might be administered, alone or in combination with other therapies for COVID-19.
T519 687-977 Sentence denotes Of note, these classes of drugs might be beneficial not only for SARS-CoV-2 infection but also for other disease in which both arms of the RAS (and of the inflammatory system) are upregulated, as for example ARDS, PAH and other pathologies associated to chronic hypoxia and cardiac failure.
T520 978-1274 Sentence denotes Indeed, both Ang-II and Ang-(1–7) upregulation and a cytokine storm are common aspects in patients not only with ARDS and PAH but also with critical coronary artery disease [182], suggesting an upregulation of both arms of the RAS and of the inflammatory system in several different dysfunctions.
T521 1275-1378 Sentence denotes Notably, a number of clinical trials have indicated the utility of CaNa2EDTA in coronary heart disease.
T522 1379-1498 Sentence denotes It was believed that chelation therapy might alter plaque morphology and volume, or improve endothelial function [123].
T523 1499-1546 Sentence denotes However, the evidence was not convincing [123].
T524 1547-1652 Sentence denotes Future clinical trials on selected patients with both ACE and ACE2 upregulation might be more convincing.
T525 1653-1782 Sentence denotes It is clear that similar pathways of activation can lead to different outcomes depending on individual predisposition/background.
T526 1783-2001 Sentence denotes Therefore, future efforts to understand the genetic, morpho-physiological, environmental and lifestyle factors that individually affect the predisposition to a specific disease with a precision medicine must be pursed.
T527 2002-2173 Sentence denotes To avoid disrupting extracellular calcium levels, CaNa2EDTA formulation is typically employed as an antidote for lead poisoning or as an extracellular zinc chelator [123].
T528 2174-2315 Sentence denotes CaNa2EDTA is poorly absorbed in the gastrointestinal tract therefore can be preferentially administered by parenteral route or by inhalation.
T529 2316-2557 Sentence denotes Nevertheless, oral tablets (e.g., 250–500 mg/tablet) or suppositories of CaNa2EDTA might also work in reducing plasma zinc levels by inhibiting intestinal zinc absorption (the only physiological way of zinc uptake by the organism) [188,189].
T530 2558-2690 Sentence denotes In this regard, eight men showing elevated lead concentrations were given a seven-day course of CaNa2EDTA, 4 g/day in divided doses.
T531 2691-2826 Sentence denotes Oral CaNa2EDTA caused a rise in lead excretion within few hours, suggesting that orally administered drug was partially absorbed [188].
T532 2827-2971 Sentence denotes Importantly, the trial in the eight lead workers demonstrated that oral administration of CaNa2EDTA was safe and produced no side-effects [188].
T533 2972-3242 Sentence denotes However, the FDA-approved method for delivery of CaNa2EDTA in treatment of lead poisoning is intravenously or intramuscularly and the recommended dose for asymptomatic adults and pediatric patients with elevated blood lead levels is 1000 g/m2/day (~0,05 g/kg/day) [190].
T534 3243-3369 Sentence denotes CaNa2EDTA was usually administered for 5–10 days followed by an interval of at least 5–10 days before a second administration.
T535 3370-3428 Sentence denotes Unfortunately, intravenous administration is very painful.
T536 3429-3712 Sentence denotes Administration of CaNa2EDTA via nebulizer has also been pursued for inhalation therapy in pulmonary metal poisonings to protect lung tissue and reduce its systemic uptaken [123]; moreover, nebulized solutions containing EDTA have been proven safe, not inducing adverse effects [191].
T537 3713-3938 Sentence denotes For the sake of completeness, the unconventional methods for administering chelating agents such as rectal or inhalatory administration are not FDA approved methods for delivery and they have not been studied in detail [192].
T538 3939-4089 Sentence denotes CaNa2EDTA diffuses mainly in the extracellular fluids, where it is not significantly metabolized, and it is excreted rapidly by glomerular filtration.
T539 4090-4188 Sentence denotes The chelator has a half-life of 1.4 to 3 h in adults and is completely excreted within 24 h [123].
T540 4189-4270 Sentence denotes For all of the above reasons, CaNa2EDTA might be employed in therapy of COVID-19.
T541 4271-4525 Sentence denotes However, before beginning any therapy with medication, particularly in the case of new diseases (such as COVID-19) or new treatments, a careful patient selection for these new treatments is essential to prevent unnecessary toxicity (“first do not harm”).

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T168 129-142 Phenotype denotes hyperactivity http://purl.obolibrary.org/obo/HP_0000752
T169 441-448 Phenotype denotes hypoxia http://purl.obolibrary.org/obo/HP_0012418
T170 949-956 Phenotype denotes hypoxia http://purl.obolibrary.org/obo/HP_0012418
T171 961-976 Phenotype denotes cardiac failure http://purl.obolibrary.org/obo/HP_0001635
T172 1031-1045 Phenotype denotes cytokine storm http://purl.obolibrary.org/obo/HP_0033041

2_test

Id Subject Object Predicate Lexical cue
32708755-27432541-20679037 1152-1155 27432541 denotes 182
32708755-20717537-20679038 1493-1496 20717537 denotes 123
32708755-20717537-20679039 1541-1544 20717537 denotes 123
32708755-20717537-20679040 2168-2171 20717537 denotes 123
32708755-14007184-20679041 2548-2551 14007184 denotes 188
32708755-14007184-20679042 2821-2824 14007184 denotes 188
32708755-14007184-20679043 2966-2969 14007184 denotes 188
32708755-20717537-20679044 3602-3605 20717537 denotes 123
32708755-11149993-20679045 3707-3710 11149993 denotes 191
32708755-20717537-20679046 4183-4186 20717537 denotes 123