PMC:7408073 / 103366-104648 JSONTXT

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LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T21 153-157 Body_part denotes sole http://purl.org/sig/ont/fma/fma25000
T22 388-392 Body_part denotes face http://purl.org/sig/ont/fma/fma24728

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T212 42-45 Body_part denotes RAS http://purl.obolibrary.org/obo/UBERON_0018229
T213 388-392 Body_part denotes face http://purl.obolibrary.org/obo/UBERON_0001456
T214 560-563 Body_part denotes RAS http://purl.obolibrary.org/obo/UBERON_0018229
T215 1155-1158 Body_part denotes RAS http://purl.obolibrary.org/obo/UBERON_0018229

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
3574 118-123 Gene denotes renin Gene:5972
3575 670-673 Gene denotes ACE Gene:59272
3576 678-682 Gene denotes ACE2 Gene:59272
3577 790-794 Gene denotes AT1R Gene:24180
3578 921-926 Gene denotes renin Gene:24715
3579 1066-1070 Gene denotes AT2R Gene:24182
3580 1075-1079 Gene denotes ACE2 Gene:59272
3581 799-803 Gene denotes MasR Gene:116511
3582 888-896 Gene denotes Ang (1–7 Gene:305843
3583 82-87 Gene denotes renin Gene:5972
3584 470-478 Species denotes patients Tax:9606
3585 751-755 Species denotes rats Tax:10116
3586 877-883 Gene denotes Ang II Gene:24179
3587 322-331 Chemical denotes Aliskiren MESH:C446481
3588 728-737 Chemical denotes Aliskiren MESH:C446481
3589 1209-1218 Chemical denotes CaNa2EDTA
3590 1222-1235 Chemical denotes nicotianamine MESH:C082893
3591 302-314 Disease denotes hypertension MESH:D006973
3592 393-401 Disease denotes COVID-19 MESH:C000657245
3593 437-457 Disease denotes SARS-CoV-2 infection MESH:C000657245
3594 503-511 Disease denotes COVID-19 MESH:C000657245
3595 512-519 Disease denotes hypoxia MESH:D000860
3596 683-696 Disease denotes hyperactivity MESH:D006948
3597 986-1006 Disease denotes SARS-CoV-2 infection MESH:C000657245

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T563 302-314 Disease denotes hypertension http://purl.obolibrary.org/obo/MONDO_0005044
T564 393-401 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T565 437-445 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T566 437-441 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T567 448-457 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T568 503-511 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T569 986-994 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T570 986-990 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T571 997-1006 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T51 98-106 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T52 388-392 http://purl.obolibrary.org/obo/UBERON_0001456 denotes face
T53 548-552 http://www.ebi.ac.uk/efo/EFO_0001410 denotes arms
T54 595-596 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T55 756-759 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T56 842-843 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T57 1022-1025 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T58 1106-1107 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T59 1143-1147 http://www.ebi.ac.uk/efo/EFO_0001410 denotes arms

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T79112 42-45 Chemical denotes RAS http://purl.obolibrary.org/obo/CHEBI_63620
T25987 124-134 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T36125 136-145 Chemical denotes aliskiren http://purl.obolibrary.org/obo/CHEBI_601027
T21 184-189 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T68125 379-384 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T76956 560-563 Chemical denotes RAS http://purl.obolibrary.org/obo/CHEBI_63620
T7372 576-585 Chemical denotes aliskiren http://purl.obolibrary.org/obo/CHEBI_601027
T80351 656-660 Chemical denotes fuel http://purl.obolibrary.org/obo/CHEBI_33292
T53522 881-883 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T46892 898-905 Chemical denotes ligands http://purl.obolibrary.org/obo/CHEBI_52214
T73943 1155-1158 Chemical denotes RAS http://purl.obolibrary.org/obo/CHEBI_63620
T15324 1177-1183 Chemical denotes cation http://purl.obolibrary.org/obo/CHEBI_36916
T26128 1184-1200 Chemical denotes chelating agents http://purl.obolibrary.org/obo/CHEBI_38161
T93640 1222-1235 Chemical denotes nicotianamine http://purl.obolibrary.org/obo/CHEBI_25520|http://purl.obolibrary.org/obo/CHEBI_58249

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T505 0-107 Sentence denotes An alternative approach is to inhibit the RAS pathway at its origin by inhibiting renin enzymatic activity.
T506 108-321 Sentence denotes Regarding renin inhibitors, aliskiren is the sole compound in this class of drugs that was approved by the US Food and Drug Administration in March 2007 and commercialized for the management of hypertension [186].
T507 322-458 Sentence denotes Aliskiren may be used alone or in combination with other drugs to face COVID-19, in particular the severe forms of SARS-CoV-2 infection.
T508 459-564 Sentence denotes Indeed, in patients with severe symptoms of COVID-19 hypoxia might have upregulated both arms of the RAS.
T509 565-727 Sentence denotes Therefore, aliskiren might be a useful “tool” to reduce production of Ang I, the necessary fuel for both ACE and ACE2 hyperactivity and their detrimental effects.
T510 728-944 Sentence denotes Aliskiren treatment in rats has been shown to upregulate both AT1R and MasR expression probably as consequence of a compensation mechanism when both Ang II and Ang (1–7) ligands are reduced by renin inhibition [187].
T511 945-1165 Sentence denotes Of particular interest in the context of SARS-CoV-2 infection, the treatment has been shown to reduce expression of both AT2R and ACE2, thus possibly performing a multiple action in inhibiting both arms of the RAS [187].
T512 1166-1282 Sentence denotes Similarly, cation chelating agents such as CaNa2EDTA or nicotianamine might also work, although at different levels.

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T165 302-314 Phenotype denotes hypertension http://purl.obolibrary.org/obo/HP_0000822
T166 512-519 Phenotype denotes hypoxia http://purl.obolibrary.org/obo/HP_0012418
T167 683-696 Phenotype denotes hyperactivity http://purl.obolibrary.org/obo/HP_0000752