PMC:7408073 / 103321-104648 JSONTXT

Annnotations TAB JSON ListView MergeView

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T21 198-202 Body_part denotes sole http://purl.org/sig/ont/fma/fma25000
T22 433-437 Body_part denotes face http://purl.org/sig/ont/fma/fma24728

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T212 87-90 Body_part denotes RAS http://purl.obolibrary.org/obo/UBERON_0018229
T213 433-437 Body_part denotes face http://purl.obolibrary.org/obo/UBERON_0001456
T214 605-608 Body_part denotes RAS http://purl.obolibrary.org/obo/UBERON_0018229
T215 1200-1203 Body_part denotes RAS http://purl.obolibrary.org/obo/UBERON_0018229

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
3549 19-24 Gene denotes Renin Gene:5972
3574 163-168 Gene denotes renin Gene:5972
3575 715-718 Gene denotes ACE Gene:59272
3576 723-727 Gene denotes ACE2 Gene:59272
3577 835-839 Gene denotes AT1R Gene:24180
3578 966-971 Gene denotes renin Gene:24715
3579 1111-1115 Gene denotes AT2R Gene:24182
3580 1120-1124 Gene denotes ACE2 Gene:59272
3581 844-848 Gene denotes MasR Gene:116511
3582 933-941 Gene denotes Ang (1–7 Gene:305843
3583 127-132 Gene denotes renin Gene:5972
3584 515-523 Species denotes patients Tax:9606
3585 796-800 Species denotes rats Tax:10116
3586 922-928 Gene denotes Ang II Gene:24179
3587 367-376 Chemical denotes Aliskiren MESH:C446481
3588 773-782 Chemical denotes Aliskiren MESH:C446481
3589 1254-1263 Chemical denotes CaNa2EDTA
3590 1267-1280 Chemical denotes nicotianamine MESH:C082893
3591 347-359 Disease denotes hypertension MESH:D006973
3592 438-446 Disease denotes COVID-19 MESH:C000657245
3593 482-502 Disease denotes SARS-CoV-2 infection MESH:C000657245
3594 548-556 Disease denotes COVID-19 MESH:C000657245
3595 557-564 Disease denotes hypoxia MESH:D000860
3596 728-741 Disease denotes hyperactivity MESH:D006948
3597 1031-1051 Disease denotes SARS-CoV-2 infection MESH:C000657245

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T563 347-359 Disease denotes hypertension http://purl.obolibrary.org/obo/MONDO_0005044
T564 438-446 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T565 482-490 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T566 482-486 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T567 493-502 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T568 548-556 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T569 1031-1039 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T570 1031-1035 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T571 1042-1051 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T50 25-33 http://purl.obolibrary.org/obo/CLO_0001658 denotes Activity
T51 143-151 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T52 433-437 http://purl.obolibrary.org/obo/UBERON_0001456 denotes face
T53 593-597 http://www.ebi.ac.uk/efo/EFO_0001410 denotes arms
T54 640-641 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T55 801-804 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T56 887-888 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T57 1067-1070 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T58 1151-1152 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T59 1188-1192 http://www.ebi.ac.uk/efo/EFO_0001410 denotes arms

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T79112 87-90 Chemical denotes RAS http://purl.obolibrary.org/obo/CHEBI_63620
T25987 169-179 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T36125 181-190 Chemical denotes aliskiren http://purl.obolibrary.org/obo/CHEBI_601027
T21 229-234 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T68125 424-429 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T76956 605-608 Chemical denotes RAS http://purl.obolibrary.org/obo/CHEBI_63620
T7372 621-630 Chemical denotes aliskiren http://purl.obolibrary.org/obo/CHEBI_601027
T80351 701-705 Chemical denotes fuel http://purl.obolibrary.org/obo/CHEBI_33292
T53522 926-928 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T46892 943-950 Chemical denotes ligands http://purl.obolibrary.org/obo/CHEBI_52214
T73943 1200-1203 Chemical denotes RAS http://purl.obolibrary.org/obo/CHEBI_63620
T15324 1222-1228 Chemical denotes cation http://purl.obolibrary.org/obo/CHEBI_36916
T26128 1229-1245 Chemical denotes chelating agents http://purl.obolibrary.org/obo/CHEBI_38161
T93640 1267-1280 Chemical denotes nicotianamine http://purl.obolibrary.org/obo/CHEBI_25520|http://purl.obolibrary.org/obo/CHEBI_58249

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T502 0-4 Sentence denotes 8.2.
T503 5-34 Sentence denotes Inhibition of Renin Activity:
T504 35-44 Sentence denotes Aliskiren
T505 45-152 Sentence denotes An alternative approach is to inhibit the RAS pathway at its origin by inhibiting renin enzymatic activity.
T506 153-366 Sentence denotes Regarding renin inhibitors, aliskiren is the sole compound in this class of drugs that was approved by the US Food and Drug Administration in March 2007 and commercialized for the management of hypertension [186].
T507 367-503 Sentence denotes Aliskiren may be used alone or in combination with other drugs to face COVID-19, in particular the severe forms of SARS-CoV-2 infection.
T508 504-609 Sentence denotes Indeed, in patients with severe symptoms of COVID-19 hypoxia might have upregulated both arms of the RAS.
T509 610-772 Sentence denotes Therefore, aliskiren might be a useful “tool” to reduce production of Ang I, the necessary fuel for both ACE and ACE2 hyperactivity and their detrimental effects.
T510 773-989 Sentence denotes Aliskiren treatment in rats has been shown to upregulate both AT1R and MasR expression probably as consequence of a compensation mechanism when both Ang II and Ang (1–7) ligands are reduced by renin inhibition [187].
T511 990-1210 Sentence denotes Of particular interest in the context of SARS-CoV-2 infection, the treatment has been shown to reduce expression of both AT2R and ACE2, thus possibly performing a multiple action in inhibiting both arms of the RAS [187].
T512 1211-1327 Sentence denotes Similarly, cation chelating agents such as CaNa2EDTA or nicotianamine might also work, although at different levels.

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T165 347-359 Phenotype denotes hypertension http://purl.obolibrary.org/obo/HP_0000822
T166 557-564 Phenotype denotes hypoxia http://purl.obolibrary.org/obo/HP_0012418
T167 728-741 Phenotype denotes hyperactivity http://purl.obolibrary.org/obo/HP_0000752