PMC:7408073 / 101488-103319 JSONTXT

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LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T9 830-834 Body_part denotes face http://purl.org/sig/ont/fma/fma24728
T10 868-872 Body_part denotes hand http://purl.org/sig/ont/fma/fma9712
T11 1252-1257 Body_part denotes heart http://purl.org/sig/ont/fma/fma7088
T12 1258-1262 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T13 1263-1268 Body_part denotes liver http://purl.org/sig/ont/fma/fma7197
T14 1269-1278 Body_part denotes intestine http://purl.org/sig/ont/fma/fma7199
T15 1279-1285 Body_part denotes kidney http://purl.org/sig/ont/fma/fma7203
T16 1286-1299 Body_part denotes immune system http://purl.org/sig/ont/fma/fma9825
T17 1300-1305 Body_part denotes blood http://purl.org/sig/ont/fma/fma9670
T18 1447-1452 Body_part denotes blood http://purl.org/sig/ont/fma/fma9670
T19 1543-1549 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T20 1694-1698 Body_part denotes face http://purl.org/sig/ont/fma/fma24728

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T200 337-340 Body_part denotes RAS http://purl.obolibrary.org/obo/UBERON_0018229
T201 830-834 Body_part denotes face http://purl.obolibrary.org/obo/UBERON_0001456
T202 868-872 Body_part denotes hand http://purl.obolibrary.org/obo/UBERON_0002398
T203 1252-1257 Body_part denotes heart http://purl.obolibrary.org/obo/UBERON_0000948
T204 1258-1262 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T205 1263-1268 Body_part denotes liver http://purl.obolibrary.org/obo/UBERON_0002107
T206 1269-1278 Body_part denotes intestine http://purl.obolibrary.org/obo/UBERON_0000160
T207 1279-1285 Body_part denotes kidney http://purl.obolibrary.org/obo/UBERON_0002113
T208 1286-1299 Body_part denotes immune system http://purl.obolibrary.org/obo/UBERON_0002405
T209 1300-1305 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T210 1447-1452 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T211 1694-1698 Body_part denotes face http://purl.obolibrary.org/obo/UBERON_0001456

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
3528 421-424 Gene denotes ACE Gene:59272
3529 425-429 Gene denotes ACE2 Gene:59272
3530 449-452 Gene denotes ACE Gene:59272
3531 511-515 Gene denotes ACE2 Gene:59272
3532 1195-1199 Gene denotes ACE2 Gene:59272
3533 1360-1364 Gene denotes ACE2 Gene:59272
3534 1605-1609 Gene denotes ACE2 Gene:59272
3535 1003-1006 Gene denotes MLN Gene:4295
3536 691-694 Gene denotes MLN Gene:4295
3537 20-23 Gene denotes MLN Gene:4295
3538 204-212 Species denotes patients Tax:9606
3539 629-637 Species denotes patients Tax:9606
3540 1166-1174 Species denotes patients Tax:9606
3541 1425-1433 Species denotes patients Tax:9606
3542 1537-1542 Species denotes human Tax:9606
3543 1646-1654 Species denotes patients Tax:9606
3544 1813-1820 Species denotes patient Tax:9606
3545 300-318 Disease denotes hypoxic conditions MESH:D000071069
3546 620-628 Disease denotes COVID-19 MESH:C000657245
3547 1416-1424 Disease denotes COVID-19 MESH:C000657245

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T561 620-628 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T562 1416-1424 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T15 216-217 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T16 325-329 http://www.ebi.ac.uk/efo/EFO_0001410 denotes arms
T17 372-373 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T18 526-534 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T19 805-813 http://purl.obolibrary.org/obo/CLO_0001658 denotes actively
T20 830-834 http://purl.obolibrary.org/obo/UBERON_0001456 denotes face
T21 950-952 http://purl.obolibrary.org/obo/CLO_0050475 denotes my
T22 1184-1185 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T23 1252-1257 http://purl.obolibrary.org/obo/UBERON_0000948 denotes heart
T24 1252-1257 http://purl.obolibrary.org/obo/UBERON_0007100 denotes heart
T25 1252-1257 http://purl.obolibrary.org/obo/UBERON_0015228 denotes heart
T26 1252-1257 http://www.ebi.ac.uk/efo/EFO_0000815 denotes heart
T27 1258-1262 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T28 1258-1262 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T29 1263-1268 http://purl.obolibrary.org/obo/UBERON_0002107 denotes liver
T30 1263-1268 http://www.ebi.ac.uk/efo/EFO_0000887 denotes liver
T31 1269-1278 http://purl.obolibrary.org/obo/UBERON_0000160 denotes intestine
T32 1269-1278 http://www.ebi.ac.uk/efo/EFO_0000834 denotes intestine
T33 1279-1285 http://purl.obolibrary.org/obo/UBERON_0002113 denotes kidney
T34 1279-1285 http://www.ebi.ac.uk/efo/EFO_0000927 denotes kidney
T35 1279-1285 http://www.ebi.ac.uk/efo/EFO_0000929 denotes kidney
T36 1286-1299 http://purl.obolibrary.org/obo/UBERON_0002405 denotes immune system
T37 1300-1305 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T38 1300-1305 http://www.ebi.ac.uk/efo/EFO_0000296 denotes blood
T39 1447-1452 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T40 1447-1452 http://www.ebi.ac.uk/efo/EFO_0000296 denotes blood
T41 1478-1486 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T42 1525-1533 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T43 1537-1542 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T44 1543-1549 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T45 1588-1591 http://purl.obolibrary.org/obo/CLO_0001046 denotes 116
T46 1610-1620 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T47 1675-1683 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T48 1694-1698 http://purl.obolibrary.org/obo/UBERON_0001456 denotes face
T49 1742-1743 http://purl.obolibrary.org/obo/CLO_0001020 denotes a

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T57445 337-340 Chemical denotes RAS http://purl.obolibrary.org/obo/CHEBI_63620
T42648 795-803 Chemical denotes molecule http://purl.obolibrary.org/obo/CHEBI_25367
T66997 878-882 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T55490 1577-1586 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T3 1300-1317 http://purl.obolibrary.org/obo/GO_0007596 denotes blood/coagulation
T4 1306-1317 http://purl.obolibrary.org/obo/GO_0050817 denotes coagulation

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T494 0-115 Sentence denotes Different routes of MLN-4760 treatment administration can be pursued depending on the hospital condition/expertise.
T495 116-278 Sentence denotes In this exceptionally critical situation, it could be delivered to critical untreatable patients as a controlled “compassionate use”, in particular by inhalation.
T496 279-478 Sentence denotes However, when, under hypoxic conditions, both arms of the RAS are upregulated, it might have a limited action and, by shifting the balance of ACE/ACE2 ratio in favour of ACE, might be even dangerous.
T497 479-690 Sentence denotes Instead, specific inhibition of ACE2 enzymatic activity might effectively work in preventing the establishment of positive feedback loops in COVID-19 patients who are suffering from mild symptoms of the disease.
T498 691-854 Sentence denotes MLN-4760 is sold by different companies, that, in case it works, could be encouraged to manufacture the molecule, actively contributing to face this global threat.
T499 855-1002 Sentence denotes On the other hand, the drug could be also synthesized in University chemistry labs because, to my knowledge, is no longer under patent restriction.
T500 1003-1434 Sentence denotes MLN-4760, whose clinical development was abandoned after phase I trials (clinical name, ORE1001), is actually an interesting compound that could be useful for all patients in which a specific ACE2 upregulation is proven and associated to different (heart/lung/liver/intestine/kidney/immune system/blood/coagulation, etc.) pathological conditions related to ACE2 pathway downstream events, as it seems to occur in COVID-19 patients.
T501 1435-1831 Sentence denotes Although in blood of normal subjects sACE2 activity is undetectable because its catalytic activity in human plasma is masked by an endogenous inhibitor [116] and chronic ACE2 activation may be deleterious, some patients might need of sACE2 activity to better face an acute pathological condition, therefore a careful monitoring of clinical parameters should be performed during patient treatment.

2_test

Id Subject Object Predicate Lexical cue
32708755-18223027-20679036 1588-1591 18223027 denotes 116