
PMC:7408073 / 1001-3875
Annnotations
LitCovid-PD-FMA-UBERON
Id | Subject | Object | Predicate | Lexical cue | fma_id |
---|---|---|---|---|---|
T42134 | 805-816 | Body_part | denotes | eosinophils | http://purl.org/sig/ont/fma/fma62861 |
T20834 | 1061-1069 | Body_part | denotes | cytokine | http://purl.org/sig/ont/fma/fma84050 |
T67033 | 1093-1097 | Body_part | denotes | IL-1 | http://purl.org/sig/ont/fma/fma86583 |
T79726 | 2372-2382 | Body_part | denotes | eosinophil | http://purl.org/sig/ont/fma/fma62861 |
T26227 | 2449-2459 | Body_part | denotes | eosinophil | http://purl.org/sig/ont/fma/fma62861 |
T2518 | 2794-2800 | Body_part | denotes | kidney | http://purl.org/sig/ont/fma/fma7203 |
LitCovid-PD-UBERON
Id | Subject | Object | Predicate | Lexical cue | uberon_id |
---|---|---|---|---|---|
T6 | 2794-2800 | Body_part | denotes | kidney | http://purl.obolibrary.org/obo/UBERON_0002113 |
LitCovid-PubTator
Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
---|---|---|---|---|---|
88 | 1093-1098 | Gene | denotes | IL-1β | Gene:3552 |
89 | 1100-1104 | Gene | denotes | IL-6 | Gene:3569 |
90 | 1106-1110 | Gene | denotes | IL-8 | Gene:3576 |
91 | 1112-1117 | Gene | denotes | IL-10 | Gene:3586 |
92 | 1122-1126 | Gene | denotes | TNFα | Gene:7124 |
93 | 10-57 | Species | denotes | severe acute respiratory syndrome coronavirus 2 | Tax:2697049 |
94 | 59-69 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
95 | 259-267 | Species | denotes | patients | Tax:9606 |
96 | 678-686 | Species | denotes | patients | Tax:9606 |
97 | 710-718 | Species | denotes | patients | Tax:9606 |
98 | 1393-1401 | Species | denotes | patients | Tax:9606 |
99 | 1451-1459 | Species | denotes | patients | Tax:9606 |
100 | 1816-1823 | Species | denotes | patient | Tax:9606 |
101 | 1856-1864 | Species | denotes | patients | Tax:9606 |
102 | 2312-2320 | Species | denotes | patients | Tax:9606 |
103 | 2605-2613 | Species | denotes | patients | Tax:9606 |
104 | 2809-2817 | Species | denotes | patients | Tax:9606 |
105 | 2865-2873 | Species | denotes | patients | Tax:9606 |
106 | 2322-2325 | Gene | denotes | Th2 | Gene:15111 |
107 | 306-312 | Chemical | denotes | oxygen | MESH:D010100 |
108 | 364-375 | Chemical | denotes | chloroquine | MESH:D002738 |
109 | 381-391 | Chemical | denotes | macrolides | MESH:D018942 |
110 | 71-80 | Disease | denotes | infection | MESH:D007239 |
111 | 101-109 | Disease | denotes | COVID-19 | MESH:C000657245 |
112 | 239-247 | Disease | denotes | COVID-19 | MESH:C000657245 |
113 | 248-257 | Disease | denotes | infection | MESH:D007239 |
114 | 425-445 | Disease | denotes | SARS-CoV-2 infection | MESH:C000657245 |
115 | 548-574 | Disease | denotes | acute respiratory syndrome | MESH:D012120 |
116 | 597-602 | Disease | denotes | death | MESH:D003643 |
117 | 727-756 | Disease | denotes | lymphopaenia and eosinopaenia | |
118 | 834-846 | Disease | denotes | eosinopaenia | |
119 | 947-973 | Disease | denotes | cardiac dysfunction/injury | MESH:D006331 |
120 | 975-1003 | Disease | denotes | respiratory distress/illness | MESH:D012140 |
121 | 1005-1045 | Disease | denotes | coagulopathy, hypoproteinaemia, acidosis | MESH:D000138 |
122 | 1047-1054 | Disease | denotes | hypoxia | MESH:D000860 |
123 | 1162-1174 | Disease | denotes | hypertension | MESH:D006973 |
124 | 1255-1269 | Disease | denotes | severe disease | MESH:D045169 |
125 | 1333-1339 | Disease | denotes | asthma | MESH:D001249 |
126 | 1384-1392 | Disease | denotes | infected | MESH:D007239 |
127 | 1442-1450 | Disease | denotes | allergic | MESH:D004342 |
128 | 1554-1560 | Disease | denotes | asthma | MESH:D001249 |
129 | 1622-1638 | Disease | denotes | Viral infections | MESH:D001102 |
130 | 1668-1684 | Disease | denotes | allergic disease | MESH:D004342 |
131 | 1995-2015 | Disease | denotes | hypertensive disease | MESH:D006973 |
132 | 2106-2121 | Disease | denotes | virus infection | MESH:D001102 |
133 | 2166-2178 | Disease | denotes | hypertension | MESH:D006973 |
134 | 2303-2311 | Disease | denotes | infected | MESH:D007239 |
135 | 2335-2352 | Disease | denotes | allergic diseases | MESH:D004342 |
136 | 2509-2521 | Disease | denotes | hypertensive | MESH:D006973 |
137 | 2583-2591 | Disease | denotes | COVID-19 | MESH:C000657245 |
138 | 2629-2650 | Disease | denotes | chronic renal disease | MESH:D051436 |
139 | 2786-2808 | Disease | denotes | chronic kidney disease | MESH:D051436 |
140 | 2842-2850 | Disease | denotes | COVID-19 | MESH:C000657245 |
141 | 2858-2864 | Disease | denotes | asthma | MESH:D001249 |
LitCovid-PD-MONDO
Id | Subject | Object | Predicate | Lexical cue | mondo_id |
---|---|---|---|---|---|
T7 | 10-57 | Disease | denotes | severe acute respiratory syndrome coronavirus 2 | http://purl.obolibrary.org/obo/MONDO_0100096 |
T8 | 10-43 | Disease | denotes | severe acute respiratory syndrome | http://purl.obolibrary.org/obo/MONDO_0005091 |
T9 | 59-67 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
T10 | 59-63 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
T11 | 71-80 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
T12 | 101-109 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
T13 | 239-247 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
T14 | 248-257 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
T15 | 425-433 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
T16 | 425-429 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
T17 | 436-445 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
T18 | 541-574 | Disease | denotes | severe acute respiratory syndrome | http://purl.obolibrary.org/obo/MONDO_0005091 |
T19 | 576-580 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
T20 | 914-918 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
T21 | 967-973 | Disease | denotes | injury | http://purl.obolibrary.org/obo/MONDO_0021178 |
T22 | 1005-1017 | Disease | denotes | coagulopathy | http://purl.obolibrary.org/obo/MONDO_0001531 |
T23 | 1037-1045 | Disease | denotes | acidosis | http://purl.obolibrary.org/obo/MONDO_0006022 |
T24 | 1162-1174 | Disease | denotes | hypertension | http://purl.obolibrary.org/obo/MONDO_0005044 |
T25 | 1333-1339 | Disease | denotes | asthma | http://purl.obolibrary.org/obo/MONDO_0004979 |
T26 | 1442-1450 | Disease | denotes | allergic | http://purl.obolibrary.org/obo/MONDO_0004980 |
T27 | 1554-1560 | Disease | denotes | asthma | http://purl.obolibrary.org/obo/MONDO_0004979 |
T28 | 1622-1638 | Disease | denotes | Viral infections | http://purl.obolibrary.org/obo/MONDO_0005108 |
T29 | 1668-1684 | Disease | denotes | allergic disease | http://purl.obolibrary.org/obo/MONDO_0005271 |
T30 | 1668-1676 | Disease | denotes | allergic | http://purl.obolibrary.org/obo/MONDO_0004980 |
T31 | 1968-1972 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
T32 | 1995-2015 | Disease | denotes | hypertensive disease | http://purl.obolibrary.org/obo/MONDO_0005044 |
T33 | 2106-2121 | Disease | denotes | virus infection | http://purl.obolibrary.org/obo/MONDO_0005108 |
T34 | 2112-2121 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
T35 | 2166-2178 | Disease | denotes | hypertension | http://purl.obolibrary.org/obo/MONDO_0005044 |
T36 | 2335-2352 | Disease | denotes | allergic diseases | http://purl.obolibrary.org/obo/MONDO_0005271 |
T37 | 2335-2343 | Disease | denotes | allergic | http://purl.obolibrary.org/obo/MONDO_0004980 |
T38 | 2426-2430 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
T39 | 2583-2591 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
T40 | 2629-2650 | Disease | denotes | chronic renal disease | http://purl.obolibrary.org/obo/MONDO_0005300 |
T41 | 2637-2650 | Disease | denotes | renal disease | http://purl.obolibrary.org/obo/MONDO_0002118|http://purl.obolibrary.org/obo/MONDO_0005240 |
T43 | 2786-2808 | Disease | denotes | chronic kidney disease | http://purl.obolibrary.org/obo/MONDO_0005300 |
T44 | 2794-2808 | Disease | denotes | kidney disease | http://purl.obolibrary.org/obo/MONDO_0001343|http://purl.obolibrary.org/obo/MONDO_0005240 |
T46 | 2842-2850 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
T47 | 2858-2864 | Disease | denotes | asthma | http://purl.obolibrary.org/obo/MONDO_0004979 |
LitCovid-PD-CLO
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T92165 | 781-790 | http://www.ebi.ac.uk/efo/EFO_0000876 | denotes | extremely |
T23402 | 854-855 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T30677 | 1059-1060 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T96031 | 1106-1110 | http://purl.obolibrary.org/obo/CLO_0053704 | denotes | IL-8 |
T99826 | 1380-1383 | http://purl.obolibrary.org/obo/CLO_0001414 | denotes | 548 |
T43843 | 1954-1959 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
T60553 | 2078-2079 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T56639 | 2106-2111 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
T28761 | 2208-2210 | http://purl.obolibrary.org/obo/CLO_0050510 | denotes | 18 |
T99781 | 2250-2252 | http://purl.obolibrary.org/obo/CLO_0053733 | denotes | 11 |
T70533 | 2400-2401 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T72708 | 2794-2800 | http://purl.obolibrary.org/obo/UBERON_0002113 | denotes | kidney |
T15863 | 2794-2800 | http://www.ebi.ac.uk/efo/EFO_0000927 | denotes | kidney |
T37184 | 2794-2800 | http://www.ebi.ac.uk/efo/EFO_0000929 | denotes | kidney |
LitCovid-PD-CHEBI
Id | Subject | Object | Predicate | Lexical cue | chebi_id |
---|---|---|---|---|---|
T15 | 306-312 | Chemical | denotes | oxygen | http://purl.obolibrary.org/obo/CHEBI_25805 |
T16 | 334-349 | Chemical | denotes | glucocorticoids | http://purl.obolibrary.org/obo/CHEBI_24261 |
T17 | 364-375 | Chemical | denotes | chloroquine | http://purl.obolibrary.org/obo/CHEBI_3638 |
T18 | 381-391 | Chemical | denotes | macrolides | http://purl.obolibrary.org/obo/CHEBI_25106 |
T19 | 877-886 | Chemical | denotes | biomarker | http://purl.obolibrary.org/obo/CHEBI_59163 |
T20 | 1093-1095 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
T22 | 1100-1102 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
T24 | 1106-1108 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
T26 | 1112-1114 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
T28 | 2036-2052 | Chemical | denotes | antihypertensive | http://purl.obolibrary.org/obo/CHEBI_35674 |
LitCovid-PD-GO-BP
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T46890 | 624-629 | http://purl.obolibrary.org/obo/GO_0007568 | denotes | Aging |
T87124 | 1622-1638 | http://purl.obolibrary.org/obo/GO_0016032 | denotes | Viral infections |
LitCovid-sentences
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T9 | 0-177 | Sentence | denotes | The novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is the cause of the COVID-19 pandemic, for which there is currently no specific pharmacotherapy. |
T10 | 178-420 | Sentence | denotes | In the intensive care unit, depending on the severity of the COVID-19 infection, patients might receive supportive care such as oxygen supply, interferons, glucocorticoids, anti-virals, chloroquine, and macrolides given as deemed appropriate. |
T11 | 421-623 | Sentence | denotes | The SARS-CoV-2 infection produces either non-severe or severe symptoms and, in the latter case, it may precipitate into severe acute respiratory syndrome (SARS) and ultimately death [1,2,3,4,5,6,7,8,9]. |
T12 | 624-704 | Sentence | denotes | Aging and different comorbidities are associated with patients’ critical status. |
T13 | 705-891 | Sentence | denotes | Most patients display lymphopaenia and eosinopaenia, and critical ones show extremely low levels of eosinophils, suggesting that eosinopaenia may be a potential diagnostic biomarker [1]. |
T14 | 892-1147 | Sentence | denotes | Most serious cases of SARS are closely associated with cardiac dysfunction/injury, respiratory distress/illness, coagulopathy, hypoproteinaemia, acidosis, hypoxia and a cytokine storm mainly involving IL-1β, IL-6, IL-8, IL-10 and TNFα [1,2,3,4,5,6,7,8,9]. |
T15 | 1148-1621 | Sentence | denotes | For instance, hypertension, an age-related disease, is the most common comorbidity (15–31% up to 24–58% in severe disease cases according to clinical reports), while only five cases of asthma (0.9%) were identified in one report of 548 infected patients in Wuhan [6], but no other asthmatic or allergic patients were described in other reports [1,2,3,4,5,7,8,9], considering that the overall prevalence of asthma is estimated to be 6.4% in Wuhan [6] and ~ 4% in China [10]. |
T16 | 1622-1787 | Sentence | denotes | Viral infections usually increase the risk of allergic disease exacerbation [1]; however, the reported data seem to suggest that, in this case, the opposite is true. |
T17 | 1788-2254 | Sentence | denotes | Indeed, in more than 72.000 patient cohorts examined, the number of patients defined as asthmatic was low (5), which suggests that asthmatics might be protected from virus-induced SARS, whereas pre-existing hypertensive disease and/or pre-existing antihypertensive treatments may represent a risk factor for increased virus infection, considering that the overall prevalence of hypertension in Chinese adult population ≥18 years of age is estimated to be ~ 23% [11]. |
T18 | 2255-2557 | Sentence | denotes | Therefore, according to the clinical picture of infected patients, Th2-mediated allergic diseases (usually with high eosinophil counts) may play a protective role against SARS (usually with low eosinophil counts), while yet unknown mechanisms related to hypertensive conditions may exacerbate symptoms. |
T19 | 2558-2874 | Sentence | denotes | To complete the picture, COVID-19 hospitalized patients suffering from chronic renal disease were usually low (0-3%) [1,2,3,4,5,6,7,8,9] if compared with the prevalence of the disease in China (10.2-11.3%) [12], suggesting that chronic kidney disease patients might be protected from COVID-19 as for asthma patients. |
LitCovid-PD-HP
Id | Subject | Object | Predicate | Lexical cue | hp_id |
---|---|---|---|---|---|
T2 | 975-995 | Phenotype | denotes | respiratory distress | http://purl.obolibrary.org/obo/HP_0002098 |
T3 | 1005-1017 | Phenotype | denotes | coagulopathy | http://purl.obolibrary.org/obo/HP_0003256 |
T4 | 1037-1045 | Phenotype | denotes | acidosis | http://purl.obolibrary.org/obo/HP_0001941 |
T5 | 1047-1054 | Phenotype | denotes | hypoxia | http://purl.obolibrary.org/obo/HP_0012418 |
T6 | 1061-1075 | Phenotype | denotes | cytokine storm | http://purl.obolibrary.org/obo/HP_0033041 |
T7 | 1162-1174 | Phenotype | denotes | hypertension | http://purl.obolibrary.org/obo/HP_0000822 |
T8 | 1333-1339 | Phenotype | denotes | asthma | http://purl.obolibrary.org/obo/HP_0002099 |
T9 | 1554-1560 | Phenotype | denotes | asthma | http://purl.obolibrary.org/obo/HP_0002099 |
T10 | 2166-2178 | Phenotype | denotes | hypertension | http://purl.obolibrary.org/obo/HP_0000822 |
T11 | 2786-2808 | Phenotype | denotes | chronic kidney disease | http://purl.obolibrary.org/obo/HP_0012622 |
T12 | 2858-2864 | Phenotype | denotes | asthma | http://purl.obolibrary.org/obo/HP_0002099 |
2_test
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
32708755-32077115-20678617 | 604-605 | 32077115 | denotes | 1 |
32708755-32161940-20678618 | 606-607 | 32161940 | denotes | 2 |
32708755-32171076-20678619 | 608-609 | 32171076 | denotes | 3 |
32708755-32109013-20678620 | 612-613 | 32109013 | denotes | 5 |
32708755-32294485-20678621 | 614-615 | 32294485 | denotes | 6 |
32708755-32091533-20678622 | 616-617 | 32091533 | denotes | 7 |
32708755-31986264-20678623 | 618-619 | 31986264 | denotes | 8 |
32708755-32297671-20678624 | 620-621 | 32297671 | denotes | 9 |
32708755-32077115-20678625 | 888-889 | 32077115 | denotes | 1 |
32708755-32077115-20678626 | 1128-1129 | 32077115 | denotes | 1 |
32708755-32161940-20678627 | 1130-1131 | 32161940 | denotes | 2 |
32708755-32171076-20678628 | 1132-1133 | 32171076 | denotes | 3 |
32708755-32109013-20678629 | 1136-1137 | 32109013 | denotes | 5 |
32708755-32294485-20678630 | 1138-1139 | 32294485 | denotes | 6 |
32708755-32091533-20678631 | 1140-1141 | 32091533 | denotes | 7 |
32708755-31986264-20678632 | 1142-1143 | 31986264 | denotes | 8 |
32708755-32297671-20678633 | 1144-1145 | 32297671 | denotes | 9 |
32708755-32294485-20678634 | 1412-1413 | 32294485 | denotes | 6 |
32708755-32077115-20678635 | 1493-1494 | 32077115 | denotes | 1 |
32708755-32161940-20678636 | 1495-1496 | 32161940 | denotes | 2 |
32708755-32171076-20678637 | 1497-1498 | 32171076 | denotes | 3 |
32708755-32109013-20678638 | 1501-1502 | 32109013 | denotes | 5 |
32708755-32091533-20678639 | 1503-1504 | 32091533 | denotes | 7 |
32708755-31986264-20678640 | 1505-1506 | 31986264 | denotes | 8 |
32708755-32297671-20678641 | 1507-1508 | 32297671 | denotes | 9 |
32708755-32294485-20678642 | 1595-1596 | 32294485 | denotes | 6 |
32708755-31230828-20678643 | 1617-1619 | 31230828 | denotes | 10 |
32708755-32077115-20678644 | 1699-1700 | 32077115 | denotes | 1 |
32708755-29449338-20678645 | 2250-2252 | 29449338 | denotes | 11 |
32708755-32077115-20678646 | 2676-2677 | 32077115 | denotes | 1 |
32708755-32161940-20678647 | 2678-2679 | 32161940 | denotes | 2 |
32708755-32171076-20678648 | 2680-2681 | 32171076 | denotes | 3 |
32708755-32109013-20678649 | 2684-2685 | 32109013 | denotes | 5 |
32708755-32294485-20678650 | 2686-2687 | 32294485 | denotes | 6 |
32708755-32091533-20678651 | 2688-2689 | 32091533 | denotes | 7 |
32708755-31986264-20678652 | 2690-2691 | 31986264 | denotes | 8 |
32708755-32297671-20678653 | 2692-2693 | 32297671 | denotes | 9 |
32708755-22386035-20678654 | 2765-2767 | 22386035 | denotes | 12 |