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PMC:7408073 JSONTXT

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LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T1 100124-100139 Body_part denotes digestive tract http://purl.org/sig/ont/fma/fma317863
T2 100168-100173 Body_part denotes bowel http://purl.org/sig/ont/fma/fma7199
T3 100629-100634 Body_part denotes blood http://purl.org/sig/ont/fma/fma9670
T4 100685-100693 Body_part denotes capsules http://purl.org/sig/ont/fma/fma85272
T5 100829-100837 Body_part denotes capsules http://purl.org/sig/ont/fma/fma85272
T6 101062-101066 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T7 101223-101227 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T8 101295-101312 Body_part denotes respiratory tract http://purl.org/sig/ont/fma/fma265130
T9 102318-102322 Body_part denotes face http://purl.org/sig/ont/fma/fma24728
T10 102356-102360 Body_part denotes hand http://purl.org/sig/ont/fma/fma9712
T11 102740-102745 Body_part denotes heart http://purl.org/sig/ont/fma/fma7088
T12 102746-102750 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T13 102751-102756 Body_part denotes liver http://purl.org/sig/ont/fma/fma7197
T14 102757-102766 Body_part denotes intestine http://purl.org/sig/ont/fma/fma7199
T15 102767-102773 Body_part denotes kidney http://purl.org/sig/ont/fma/fma7203
T16 102774-102787 Body_part denotes immune system http://purl.org/sig/ont/fma/fma9825
T17 102788-102793 Body_part denotes blood http://purl.org/sig/ont/fma/fma9670
T18 102935-102940 Body_part denotes blood http://purl.org/sig/ont/fma/fma9670
T19 103031-103037 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T20 103182-103186 Body_part denotes face http://purl.org/sig/ont/fma/fma24728
T21 103519-103523 Body_part denotes sole http://purl.org/sig/ont/fma/fma25000
T22 103754-103758 Body_part denotes face http://purl.org/sig/ont/fma/fma24728
T23 104932-104944 Body_part denotes cell surface http://purl.org/sig/ont/fma/fma67653
T24 104932-104936 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T25 105681-105689 Body_part denotes cytokine http://purl.org/sig/ont/fma/fma84050
T26 105777-105792 Body_part denotes coronary artery http://purl.org/sig/ont/fma/fma49893
T27 106014-106019 Body_part denotes heart http://purl.org/sig/ont/fma/fma7088
T28 106860-106882 Body_part denotes gastrointestinal tract http://purl.org/sig/ont/fma/fma71132
T29 107077-107083 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T30 107110-107120 Body_part denotes intestinal http://purl.org/sig/ont/fma/fma7199
T31 107834-107839 Body_part denotes blood http://purl.org/sig/ont/fma/fma9670
T32 108207-108211 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T33 108212-108218 Body_part denotes tissue http://purl.org/sig/ont/fma/fma9637
T34 109337-109341 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T35 110135-110141 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T36 110923-110928 Body_part denotes blood http://purl.org/sig/ont/fma/fma9670
T37 110939-110949 Body_part denotes eosinophil http://purl.org/sig/ont/fma/fma62861
T38 111107-111123 Body_part denotes epithelial cells http://purl.org/sig/ont/fma/fma66768
T39 111118-111123 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T40 113188-113192 Body_part denotes face http://purl.org/sig/ont/fma/fma24728
T41 113540-113544 Body_part denotes sole http://purl.org/sig/ont/fma/fma25000
T42 113556-113560 Body_part denotes sole http://purl.org/sig/ont/fma/fma25000
T42134 1806-1817 Body_part denotes eosinophils http://purl.org/sig/ont/fma/fma62861
T20834 2062-2070 Body_part denotes cytokine http://purl.org/sig/ont/fma/fma84050
T67033 2094-2098 Body_part denotes IL-1 http://purl.org/sig/ont/fma/fma86583
T79726 3373-3383 Body_part denotes eosinophil http://purl.org/sig/ont/fma/fma62861
T26227 3450-3460 Body_part denotes eosinophil http://purl.org/sig/ont/fma/fma62861
T2518 3795-3801 Body_part denotes kidney http://purl.org/sig/ont/fma/fma7203
T21234 4015-4022 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T2030 4081-4086 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T47742 4132-4148 Body_part denotes epithelial cells http://purl.org/sig/ont/fma/fma66768
T6114 4143-4148 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T36553 4162-4179 Body_part denotes endothelial cells http://purl.org/sig/ont/fma/fma66772
T93384 4174-4179 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T78860 4249-4253 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T18627 4311-4318 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T66005 4355-4362 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T74461 4412-4416 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T26291 4444-4448 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T89422 4449-4454 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T39415 4612-4624 Body_part denotes cell surface http://purl.org/sig/ont/fma/fma67653
T6412 4612-4616 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T55226 4641-4650 Body_part denotes epithelia http://purl.org/sig/ont/fma/fma9639
T86589 4732-4739 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T74128 4998-5005 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T10664 5027-5031 Body_part denotes IL-1 http://purl.org/sig/ont/fma/fma86583
T4715 5055-5064 Body_part denotes cytokines http://purl.org/sig/ont/fma/fma84050
T30405 5071-5080 Body_part denotes cytokines http://purl.org/sig/ont/fma/fma84050
T89383 5245-5254 Body_part denotes epithelia http://purl.org/sig/ont/fma/fma9639
T34441 5355-5362 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T53940 5387-5394 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T48489 5428-5433 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T22482 5489-5496 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T54868 5868-5875 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T83587 5898-5903 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T57345 6535-6542 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T54062 6629-6644 Body_part denotes protein complex http://purl.org/sig/ont/fma/fma67906
T62408 6983-6987 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T81532 7026-7031 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T50862 7305-7325 Body_part denotes bronchial epithelium http://purl.org/sig/ont/fma/fma67782
T15477 7315-7325 Body_part denotes epithelium http://purl.org/sig/ont/fma/fma9639
T22792 7423-7439 Body_part denotes epithelial cells http://purl.org/sig/ont/fma/fma66768
T24903 7434-7439 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T67719 7610-7617 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T43 7714-7718 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T44 7837-7854 Body_part denotes protein complexes http://purl.org/sig/ont/fma/fma67906
T45 7837-7844 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T46 7921-7929 Body_part denotes antibody http://purl.org/sig/ont/fma/fma62871
T47 8027-8034 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T48 8198-8206 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T49 8237-8241 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T50 8242-8257 Body_part denotes plasma-membrane http://purl.org/sig/ont/fma/fma63841
T51 8294-8307 Body_part denotes glycoproteins http://purl.org/sig/ont/fma/fma62925
T52 8383-8390 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T53 8451-8459 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T54 8755-8767 Body_part denotes glycoprotein http://purl.org/sig/ont/fma/fma62925
T55 8939-8943 Body_part denotes hand http://purl.org/sig/ont/fma/fma9712
T56 9011-9015 Body_part denotes hand http://purl.org/sig/ont/fma/fma9712
T57 9050-9067 Body_part denotes cellular membrane http://purl.org/sig/ont/fma/fma63841
T58 9098-9102 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T59 9475-9485 Body_part denotes amino acid http://purl.org/sig/ont/fma/fma82739
T60 9552-9559 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T61 9630-9637 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T62 9835-9848 Body_part denotes cell membrane http://purl.org/sig/ont/fma/fma63841
T63 9835-9839 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T64 10031-10035 Body_part denotes neck http://purl.org/sig/ont/fma/fma7155
T65 10089-10094 Body_part denotes helix http://purl.org/sig/ont/fma/fma60992
T66 10199-10210 Body_part denotes amino acids http://purl.org/sig/ont/fma/fma82739
T67 10250-10254 Body_part denotes neck http://purl.org/sig/ont/fma/fma7155
T68 10519-10531 Body_part denotes cell surface http://purl.org/sig/ont/fma/fma67653
T69 10519-10523 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T70 10592-10597 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T71 10683-10687 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T72 10731-10740 Body_part denotes endosomal http://purl.org/sig/ont/fma/fma67180
T73 10811-10818 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T74 11092-11099 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T75 11230-11238 Body_part denotes cytokine http://purl.org/sig/ont/fma/fma84050
T76 11304-11312 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T77 11684-11689 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T78 11839-11845 Body_part denotes sputum http://purl.org/sig/ont/fma/fma312401
T79 11934-11940 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T80 11947-11950 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T81 12012-12023 Body_part denotes lymphocytes http://purl.org/sig/ont/fma/fma62863
T82 12041-12044 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T83 12077-12080 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T84 12086-12092 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T85 12108-12111 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T86 12209-12215 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T87 12463-12469 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T88 12470-12473 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T89 12803-12807 Body_part denotes hand http://purl.org/sig/ont/fma/fma9712
T90 13192-13200 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T91 13262-13269 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T92 13342-13350 Body_part denotes antibody http://purl.org/sig/ont/fma/fma62871
T93 13651-13657 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T94 14835-14839 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T95 14891-14895 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T96 15402-15424 Body_part denotes gastrointestinal tract http://purl.org/sig/ont/fma/fma71132
T97 15467-15471 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T98 15489-15495 Body_part denotes Tissue http://purl.org/sig/ont/fma/fma9637
T99 15496-15501 Body_part denotes organ http://purl.org/sig/ont/fma/fma67498
T100 15855-15860 Body_part denotes blood http://purl.org/sig/ont/fma/fma9670
T101 15964-15970 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T102 16225-16230 Body_part denotes heart http://purl.org/sig/ont/fma/fma7088
T103 16335-16344 Body_part denotes connexins http://purl.org/sig/ont/fma/fma67882
T104 16357-16369 Body_part denotes gap junction http://purl.org/sig/ont/fma/fma67423
T105 16600-16615 Body_part denotes coronary artery http://purl.org/sig/ont/fma/fma49893
T106 16767-16777 Body_part denotes myocardium http://purl.org/sig/ont/fma/fma9462
T107 16917-16922 Body_part denotes heart http://purl.org/sig/ont/fma/fma7088
T108 16996-17004 Body_part denotes platelet http://purl.org/sig/ont/fma/fma62851
T109 17329-17337 Body_part denotes platelet http://purl.org/sig/ont/fma/fma62851
T110 17887-17895 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T111 18125-18136 Body_part denotes hepatocytes http://purl.org/sig/ont/fma/fma14515
T112 18141-18158 Body_part denotes endothelial cells http://purl.org/sig/ont/fma/fma66772
T113 18153-18158 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T114 18206-18213 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T115 18246-18264 Body_part denotes hepatic parenchyma http://purl.org/sig/ont/fma/fma17540
T116 18286-18297 Body_part denotes hepatocytes http://purl.org/sig/ont/fma/fma14515
T117 18346-18353 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T118 18379-18383 Body_part denotes mRNA http://purl.org/sig/ont/fma/fma67122
T119 18385-18392 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T120 18451-18455 Body_part denotes IL-1 http://purl.org/sig/ont/fma/fma86583
T121 18510-18515 Body_part denotes blood http://purl.org/sig/ont/fma/fma9670
T122 18522-18533 Body_part denotes CD34+ cells http://purl.org/sig/ont/fma/fma0326120
T123 18528-18533 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T124 18708-18724 Body_part denotes pulmonary artery http://purl.org/sig/ont/fma/fma66326
T125 18725-18744 Body_part denotes smooth muscle cells http://purl.org/sig/ont/fma/fma14072
T126 18739-18744 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T127 18793-18797 Body_part denotes mRNA http://purl.org/sig/ont/fma/fma67122
T128 18802-18809 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T129 18992-19003 Body_part denotes endothelium http://purl.org/sig/ont/fma/fma63916
T130 19015-19021 Body_part denotes muscle http://purl.org/sig/ont/fma/fma32558
T131 19031-19045 Body_part denotes left ventricle http://purl.org/sig/ont/fma/fma7101
T132 19091-19096 Body_part denotes heart http://purl.org/sig/ont/fma/fma7088
T133 19446-19450 Body_part denotes axis http://purl.org/sig/ont/fma/fma12520
T134 19494-19498 Body_part denotes axis http://purl.org/sig/ont/fma/fma12520
T135 19502-19507 Body_part denotes lungs http://purl.org/sig/ont/fma/fma68877
T136 19604-19608 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T137 20013-20019 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T138 20053-20059 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T139 20193-20198 Body_part denotes lungs http://purl.org/sig/ont/fma/fma68877
T140 20556-20560 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T141 21209-21214 Body_part denotes heart http://purl.org/sig/ont/fma/fma7088
T142 21287-21293 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T143 21324-21329 Body_part denotes bowel http://purl.org/sig/ont/fma/fma7199
T144 21555-21559 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T145 21560-21570 Body_part denotes fibroblast http://purl.org/sig/ont/fma/fma63877
T146 21678-21682 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T147 21696-21716 Body_part denotes extracellular matrix http://purl.org/sig/ont/fma/fma9672
T148 21747-21755 Body_part denotes cytokine http://purl.org/sig/ont/fma/fma84050
T149 21814-21818 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T150 22039-22043 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T151 22142-22155 Body_part denotes cell membrane http://purl.org/sig/ont/fma/fma63841
T152 22142-22146 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T153 22464-22468 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T154 22567-22579 Body_part denotes cell surface http://purl.org/sig/ont/fma/fma67653
T155 22567-22571 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T156 22662-22666 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T157 22804-22808 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T158 22809-22816 Body_part denotes tissues http://purl.org/sig/ont/fma/fma9637
T159 23012-23016 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T160 23181-23191 Body_part denotes eosinophil http://purl.org/sig/ont/fma/fma62861
T161 23205-23210 Body_part denotes lungs http://purl.org/sig/ont/fma/fma68877
T162 23225-23233 Body_part denotes alveolar http://purl.org/sig/ont/fma/fma264783
T163 23285-23289 Body_part denotes axis http://purl.org/sig/ont/fma/fma12520
T164 23332-23342 Body_part denotes eosinophil http://purl.org/sig/ont/fma/fma62861
T165 23343-23347 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T166 23789-23795 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T167 23935-23940 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T168 24060-24072 Body_part denotes compartments http://purl.org/sig/ont/fma/fma76577
T169 24186-24196 Body_part denotes eosinophil http://purl.org/sig/ont/fma/fma62861
T170 24469-24478 Body_part denotes cytokines http://purl.org/sig/ont/fma/fma84050
T171 24646-24650 Body_part denotes axis http://purl.org/sig/ont/fma/fma12520
T172 24891-24895 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T173 25024-25028 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T174 25362-25366 Body_part denotes mRNA http://purl.org/sig/ont/fma/fma67122
T175 25381-25395 Body_part denotes left ventricle http://purl.org/sig/ont/fma/fma7101
T176 25538-25554 Body_part denotes cardiac myocytes http://purl.org/sig/ont/fma/fma14067
T177 25618-25622 Body_part denotes mRNA http://purl.org/sig/ont/fma/fma67122
T178 25803-25819 Body_part denotes cardiac myocytes http://purl.org/sig/ont/fma/fma14067
T179 25835-25863 Body_part denotes vascular smooth muscle cells http://purl.org/sig/ont/fma/fma284560
T180 25858-25863 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T181 25923-25927 Body_part denotes mRNA http://purl.org/sig/ont/fma/fma67122
T182 26418-26425 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T183 27453-27466 Body_part denotes cell membrane http://purl.org/sig/ont/fma/fma63841
T184 27453-27457 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T185 27908-27915 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T186 28519-28531 Body_part denotes glycoprotein http://purl.org/sig/ont/fma/fma62925
T187 28692-28696 Body_part denotes IL-1 http://purl.org/sig/ont/fma/fma86583
T188 28816-28821 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T189 28882-28898 Body_part denotes epithelial cells http://purl.org/sig/ont/fma/fma66768
T190 28893-28898 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T191 28925-28934 Body_part denotes cytokines http://purl.org/sig/ont/fma/fma84050
T192 28952-28956 Body_part denotes IL-1 http://purl.org/sig/ont/fma/fma86583
T193 29078-29082 Body_part denotes IL-1 http://purl.org/sig/ont/fma/fma86583
T194 29157-29166 Body_part denotes cytokines http://purl.org/sig/ont/fma/fma84050
T195 29185-29189 Body_part denotes IL-1 http://purl.org/sig/ont/fma/fma86583
T196 29583-29594 Body_part denotes cytoplasmic http://purl.org/sig/ont/fma/fma66835
T197 29844-29851 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T198 29990-29994 Body_part denotes IL-1 http://purl.org/sig/ont/fma/fma86583
T199 30140-30144 Body_part denotes hand http://purl.org/sig/ont/fma/fma9712
T200 30194-30198 Body_part denotes hand http://purl.org/sig/ont/fma/fma9712
T201 31026-31030 Body_part denotes hand http://purl.org/sig/ont/fma/fma9712
T202 31080-31084 Body_part denotes hand http://purl.org/sig/ont/fma/fma9712
T203 31093-31106 Body_part denotes immune system http://purl.org/sig/ont/fma/fma9825
T204 31645-31649 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T205 32225-32230 Body_part denotes blood http://purl.org/sig/ont/fma/fma9670
T206 32440-32445 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T207 32473-32477 Body_part denotes hand http://purl.org/sig/ont/fma/fma9712
T208 32659-32664 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T209 32679-32683 Body_part denotes hand http://purl.org/sig/ont/fma/fma9712
T210 32714-32728 Body_part denotes cell membranes http://purl.org/sig/ont/fma/fma63841
T211 32714-32718 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T212 32790-32794 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T213 34156-34162 Body_part denotes serine http://purl.org/sig/ont/fma/fma82764
T214 35008-35012 Body_part denotes mRNA http://purl.org/sig/ont/fma/fma67122
T215 35865-35870 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T216 36262-36281 Body_part denotes smooth muscle cells http://purl.org/sig/ont/fma/fma14072
T217 36276-36281 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T218 36527-36532 Body_part denotes blood http://purl.org/sig/ont/fma/fma9670
T219 36959-36964 Body_part denotes blood http://purl.org/sig/ont/fma/fma9670
T220 36986-36993 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T221 37121-37132 Body_part denotes macrophages http://purl.org/sig/ont/fma/fma63261
T222 37139-37144 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T223 37393-37398 Body_part denotes blood http://purl.org/sig/ont/fma/fma9670
T224 37415-37420 Body_part denotes heart http://purl.org/sig/ont/fma/fma7088
T225 37870-37881 Body_part denotes vasculature http://purl.org/sig/ont/fma/fma69050
T226 38321-38331 Body_part denotes amino acid http://purl.org/sig/ont/fma/fma82739
T227 38507-38514 Body_part denotes proline http://purl.org/sig/ont/fma/fma82761
T228 38782-38787 Body_part denotes heart http://purl.org/sig/ont/fma/fma7088
T229 38789-38796 Body_part denotes kidneys http://purl.org/sig/ont/fma/fma7203
T230 38798-38803 Body_part denotes liver http://purl.org/sig/ont/fma/fma7197
T231 38805-38810 Body_part denotes colon http://purl.org/sig/ont/fma/fma14543
T232 38812-38827 Body_part denotes small intestine http://purl.org/sig/ont/fma/fma7200
T233 38829-38833 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T234 38835-38840 Body_part denotes brain http://purl.org/sig/ont/fma/fma50801
T235 38886-38893 Body_part denotes tissues http://purl.org/sig/ont/fma/fma9637
T236 38920-38934 Body_part denotes cardiomyocytes http://purl.org/sig/ont/fma/fma14067
T237 38936-38947 Body_part denotes endothelium http://purl.org/sig/ont/fma/fma63916
T238 38949-38971 Body_part denotes alveolar type II cells http://purl.org/sig/ont/fma/fma62501
T239 38966-38971 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T240 38989-38994 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T241 38996-39024 Body_part denotes vascular smooth muscle cells http://purl.org/sig/ont/fma/fma284560
T242 39019-39024 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T243 39040-39052 Body_part denotes Leydig cells http://purl.org/sig/ont/fma/fma72297
T244 39047-39052 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T245 39116-39143 Body_part denotes surface of epithelial cells http://purl.org/sig/ont/fma/fma82998
T246 39138-39143 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T247 39147-39160 Body_part denotes renal tubules http://purl.org/sig/ont/fma/fma15627
T248 39162-39166 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T249 39214-39219 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T250 39285-39289 Body_part denotes axis http://purl.org/sig/ont/fma/fma12520
T251 40037-40043 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T252 40227-40233 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T253 40452-40458 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T254 40478-40485 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T255 40700-40705 Body_part denotes bowel http://purl.org/sig/ont/fma/fma7199
T256 40794-40800 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T257 40848-40854 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T258 41039-41045 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T259 41078-41084 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T260 41131-41137 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T261 41355-41361 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T262 41667-41673 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T263 41915-41920 Body_part denotes serum http://purl.org/sig/ont/fma/fma63083
T264 42126-42131 Body_part denotes serum http://purl.org/sig/ont/fma/fma63083
T265 42228-42234 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T266 42318-42323 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T267 42582-42588 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T268 42633-42638 Body_part denotes serum http://purl.org/sig/ont/fma/fma63083
T269 42818-42824 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T270 42943-42949 Body_part denotes kidney http://purl.org/sig/ont/fma/fma7203
T271 43674-43680 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T272 43949-43955 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T273 44622-44628 Body_part denotes muscle http://purl.org/sig/ont/fma/fma32558
T274 44678-44687 Body_part denotes cytokines http://purl.org/sig/ont/fma/fma84050
T275 44698-44702 Body_part denotes IL-1 http://purl.org/sig/ont/fma/fma86583
T276 44746-44755 Body_part denotes cytokines http://purl.org/sig/ont/fma/fma84050
T277 44946-44955 Body_part denotes cytokines http://purl.org/sig/ont/fma/fma84050
T278 45095-45103 Body_part denotes cytokine http://purl.org/sig/ont/fma/fma84050
T279 45117-45126 Body_part denotes monocytes http://purl.org/sig/ont/fma/fma62864
T280 45147-45151 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T281 45339-45344 Body_part denotes blood http://purl.org/sig/ont/fma/fma9670
T282 45345-45350 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T283 45444-45453 Body_part denotes cytokines http://purl.org/sig/ont/fma/fma84050
T284 45465-45469 Body_part denotes IL-1 http://purl.org/sig/ont/fma/fma86583
T285 45516-45524 Body_part denotes cytokine http://purl.org/sig/ont/fma/fma84050
T286 45552-45570 Body_part denotes pulmonary arterial http://purl.org/sig/ont/fma/fma66326
T287 45656-45660 Body_part denotes IL-1 http://purl.org/sig/ont/fma/fma86583
T288 45663-45667 Body_part denotes IL-2 http://purl.org/sig/ont/fma/fma84051
T289 45694-45699 Body_part denotes IL-12 http://purl.org/sig/ont/fma/fma86579
T290 45932-45940 Body_part denotes cytokine http://purl.org/sig/ont/fma/fma84050
T291 46359-46381 Body_part denotes gastrointestinal tract http://purl.org/sig/ont/fma/fma71132
T292 46387-46398 Body_part denotes enterocytes http://purl.org/sig/ont/fma/fma62122
T293 46445-46452 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T294 46801-46811 Body_part denotes intestinal http://purl.org/sig/ont/fma/fma7199
T295 47079-47083 Body_part denotes hand http://purl.org/sig/ont/fma/fma9712
T296 47127-47138 Body_part denotes amino acids http://purl.org/sig/ont/fma/fma82739
T297 47140-47142 Body_part denotes AA http://purl.org/sig/ont/fma/fma82739
T298 47184-47192 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T299 47383-47385 Body_part denotes AA http://purl.org/sig/ont/fma/fma82739
T300 47413-47424 Body_part denotes enterocytes http://purl.org/sig/ont/fma/fma62122
T301 47475-47485 Body_part denotes enterocyte http://purl.org/sig/ont/fma/fma62122
T302 47515-47525 Body_part denotes intestinal http://purl.org/sig/ont/fma/fma7199
T303 47558-47563 Body_part denotes blood http://purl.org/sig/ont/fma/fma9670
T304 47628-47630 Body_part denotes AA http://purl.org/sig/ont/fma/fma82739
T305 47729-47731 Body_part denotes AA http://purl.org/sig/ont/fma/fma82739
T306 47745-47747 Body_part denotes AA http://purl.org/sig/ont/fma/fma82739
T307 47770-47781 Body_part denotes enterocytes http://purl.org/sig/ont/fma/fma62122
T308 47810-47812 Body_part denotes AA http://purl.org/sig/ont/fma/fma82739
T309 47882-47884 Body_part denotes AA http://purl.org/sig/ont/fma/fma82739
T310 47937-47944 Body_part denotes insulin http://purl.org/sig/ont/fma/fma83365
T311 47984-47989 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T312 48149-48155 Body_part denotes Plasma http://purl.org/sig/ont/fma/fma62970
T313 48221-48231 Body_part denotes intestinal http://purl.org/sig/ont/fma/fma7199
T314 48391-48396 Body_part denotes blood http://purl.org/sig/ont/fma/fma9670
T315 48406-48411 Body_part denotes serum http://purl.org/sig/ont/fma/fma63083
T316 48475-48482 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T317 48486-48492 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T318 48507-48511 Body_part denotes hand http://purl.org/sig/ont/fma/fma9712
T319 48566-48568 Body_part denotes AA http://purl.org/sig/ont/fma/fma82739
T320 48715-48727 Body_part denotes blood plasma http://purl.org/sig/ont/fma/fma62970
T321 48795-48812 Body_part denotes endothelial cells http://purl.org/sig/ont/fma/fma66772
T322 48807-48812 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T323 48844-48861 Body_part denotes endothelial cells http://purl.org/sig/ont/fma/fma66772
T324 48856-48861 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T325 48914-48920 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T326 48924-48931 Body_part denotes tissues http://purl.org/sig/ont/fma/fma9637
T327 49097-49101 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T328 49118-49124 Body_part denotes Plasma http://purl.org/sig/ont/fma/fma62970
T329 49183-49195 Body_part denotes cell surface http://purl.org/sig/ont/fma/fma67653
T330 49183-49187 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T331 49204-49209 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T332 49226-49232 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T333 49251-49256 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T334 49258-49275 Body_part denotes endothelial cells http://purl.org/sig/ont/fma/fma66772
T335 49270-49275 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T336 49277-49284 Body_part denotes neurons http://purl.org/sig/ont/fma/fma54527
T337 49289-49303 Body_part denotes cardiomyocytes http://purl.org/sig/ont/fma/fma14067
T338 49567-49582 Body_part denotes plasma to cells http://purl.org/sig/ont/fma/fma70574
T339 49567-49573 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T340 49577-49582 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T341 49671-49676 Body_part denotes blood http://purl.org/sig/ont/fma/fma9670
T342 50400-50404 Body_part denotes hand http://purl.org/sig/ont/fma/fma9712
T343 50416-50422 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T344 50668-50679 Body_part denotes neural cell http://purl.org/sig/ont/fma/fma70333
T345 50675-50679 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T346 50754-50760 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T347 50789-50796 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T348 50869-50879 Body_part denotes fatty acid http://purl.org/sig/ont/fma/fma82738
T349 50881-50884 Body_part denotes FFA http://purl.org/sig/ont/fma/fma82738
T350 51181-51184 Body_part denotes FFA http://purl.org/sig/ont/fma/fma82738
T351 51417-51423 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T352 51606-51612 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T353 51876-51883 Body_part denotes heparin http://purl.org/sig/ont/fma/fma82839
T354 52084-52090 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T355 52154-52160 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T356 52264-52268 Body_part denotes hand http://purl.org/sig/ont/fma/fma9712
T357 52296-52302 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T358 52365-52371 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T359 52755-52760 Body_part denotes serum http://purl.org/sig/ont/fma/fma63083
T360 52974-52980 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T361 53046-53051 Body_part denotes liver http://purl.org/sig/ont/fma/fma7197
T362 53229-53245 Body_part denotes endothelial cell http://purl.org/sig/ont/fma/fma66772
T363 53241-53245 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T364 53301-53319 Body_part denotes pulmonary arteries http://purl.org/sig/ont/fma/fma66326
T365 53311-53319 Body_part denotes arteries http://purl.org/sig/ont/fma/fma63812
T366 53423-53431 Body_part denotes alveolar http://purl.org/sig/ont/fma/fma264783
T367 53577-53581 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T368 53632-53636 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T369 54879-54891 Body_part denotes cell surface http://purl.org/sig/ont/fma/fma67653
T370 54879-54883 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T371 54934-54941 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T372 55008-55015 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T373 55074-55089 Body_part denotes plasma membrane http://purl.org/sig/ont/fma/fma63841
T374 55276-55284 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T375 55361-55365 Body_part denotes hand http://purl.org/sig/ont/fma/fma9712
T376 55373-55380 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T377 55558-55566 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T378 55804-55812 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T379 56985-56990 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T380 58279-58285 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T381 58807-58812 Body_part denotes blood http://purl.org/sig/ont/fma/fma9670
T382 58947-58952 Body_part denotes blood http://purl.org/sig/ont/fma/fma9670
T383 59306-59311 Body_part denotes blood http://purl.org/sig/ont/fma/fma9670
T384 59432-59444 Body_part denotes baroreceptor http://purl.org/sig/ont/fma/fma85601
T385 60186-60190 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T386 61322-61327 Body_part denotes heart http://purl.org/sig/ont/fma/fma7088
T387 61329-61333 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T388 61335-61340 Body_part denotes liver http://purl.org/sig/ont/fma/fma7197
T389 61342-61347 Body_part denotes colon http://purl.org/sig/ont/fma/fma14543
T390 61357-61364 Body_part denotes tissues http://purl.org/sig/ont/fma/fma9637
T391 61396-61401 Body_part denotes blood http://purl.org/sig/ont/fma/fma9670
T392 61406-61423 Body_part denotes endothelial cells http://purl.org/sig/ont/fma/fma66772
T393 61418-61423 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T394 62144-62150 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T395 62286-62292 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T396 62362-62368 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T397 63326-63331 Body_part denotes blood http://purl.org/sig/ont/fma/fma9670
T398 63630-63634 Body_part denotes body http://purl.org/sig/ont/fma/fma256135
T399 63636-63641 Body_part denotes Cells http://purl.org/sig/ont/fma/fma68646
T400 63768-63774 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T401 64091-64096 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T402 64184-64199 Body_part denotes plasma membrane http://purl.org/sig/ont/fma/fma63841
T403 64619-64628 Body_part denotes lysosomes http://purl.org/sig/ont/fma/fma63836
T404 64930-64938 Body_part denotes platelet http://purl.org/sig/ont/fma/fma62851
T405 64978-64986 Body_part denotes platelet http://purl.org/sig/ont/fma/fma62851
T406 65035-65053 Body_part denotes secretory granules http://purl.org/sig/ont/fma/fma84758
T407 65117-65125 Body_part denotes platelet http://purl.org/sig/ont/fma/fma62851
T408 66130-66142 Body_part denotes renal artery http://purl.org/sig/ont/fma/fma14751
T409 66407-66417 Body_part denotes neutrophil http://purl.org/sig/ont/fma/fma62860
T410 66682-66688 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T411 66826-66833 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T412 66837-66843 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T413 66887-66889 Body_part denotes AA http://purl.org/sig/ont/fma/fma82739
T414 66989-66991 Body_part denotes AA http://purl.org/sig/ont/fma/fma82739
T415 67042-67053 Body_part denotes amino acids http://purl.org/sig/ont/fma/fma82739
T416 67105-67107 Body_part denotes AA http://purl.org/sig/ont/fma/fma82739
T417 67492-67502 Body_part denotes amino acid http://purl.org/sig/ont/fma/fma82739
T418 67667-67675 Body_part denotes arginine http://purl.org/sig/ont/fma/fma82763
T419 67906-67913 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T420 68593-68599 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T421 68952-68962 Body_part denotes intestinal http://purl.org/sig/ont/fma/fma7199
T422 69541-69549 Body_part denotes cavities http://purl.org/sig/ont/fma/fma76576
T423 70609-70616 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T424 71579-71585 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T425 72676-72690 Body_part denotes left ventricle http://purl.org/sig/ont/fma/fma7101
T426 72725-72731 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T427 73296-73303 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T428 73324-73340 Body_part denotes pulmonary artery http://purl.org/sig/ont/fma/fma66326
T429 73341-73360 Body_part denotes smooth muscle cells http://purl.org/sig/ont/fma/fma14072
T430 73355-73360 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T431 75176-75180 Body_part denotes face http://purl.org/sig/ont/fma/fma24728
T432 75617-75624 Body_part denotes insulin http://purl.org/sig/ont/fma/fma83365
T433 75761-75765 Body_part denotes hand http://purl.org/sig/ont/fma/fma9712
T434 75782-75789 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T435 75817-75823 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T436 75831-75836 Body_part denotes urine http://purl.org/sig/ont/fma/fma12274
T437 76194-76200 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T438 76210-76214 Body_part denotes mRNA http://purl.org/sig/ont/fma/fma67122
T439 76225-76230 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T440 76253-76257 Body_part denotes hand http://purl.org/sig/ont/fma/fma9712
T441 76342-76347 Body_part denotes bowel http://purl.org/sig/ont/fma/fma7199
T442 76463-76468 Body_part denotes heart http://purl.org/sig/ont/fma/fma7088
T443 76560-76566 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T444 77139-77146 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T445 77727-77733 Body_part denotes kidney http://purl.org/sig/ont/fma/fma7203
T446 77971-77976 Body_part denotes blood http://purl.org/sig/ont/fma/fma9670
T447 77993-78000 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T448 78019-78025 Body_part denotes kidney http://purl.org/sig/ont/fma/fma7203
T449 78268-78273 Body_part denotes urine http://purl.org/sig/ont/fma/fma12274
T450 78312-78319 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T451 78600-78605 Body_part denotes blood http://purl.org/sig/ont/fma/fma9670
T452 78951-78956 Body_part denotes organ http://purl.org/sig/ont/fma/fma67498
T453 78971-78975 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T454 78976-78983 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T455 79105-79109 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T456 79291-79299 Body_part denotes intronic http://purl.org/sig/ont/fma/fma84121
T457 79497-79501 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T458 79522-79526 Body_part denotes hand http://purl.org/sig/ont/fma/fma9712
T459 81060-81065 Body_part denotes blood http://purl.org/sig/ont/fma/fma9670
T460 82548-82554 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T461 82884-82887 Body_part denotes V-2 http://purl.org/sig/ont/fma/fma13443|http://purl.org/sig/ont/fma/fma68615
T463 83194-83198 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T464 83199-83211 Body_part denotes eosinophilic http://purl.org/sig/ont/fma/fma62861
T465 83296-83306 Body_part denotes eosinophil http://purl.org/sig/ont/fma/fma62861
T466 83548-83552 Body_part denotes hand http://purl.org/sig/ont/fma/fma9712
T467 83609-83617 Body_part denotes cytokine http://purl.org/sig/ont/fma/fma84050
T468 83647-83652 Body_part denotes serum http://purl.org/sig/ont/fma/fma63083
T469 83653-83662 Body_part denotes cytokines http://purl.org/sig/ont/fma/fma84050
T470 83732-83741 Body_part denotes cytokines http://purl.org/sig/ont/fma/fma84050
T471 83784-83789 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T472 83862-83870 Body_part denotes cytokine http://purl.org/sig/ont/fma/fma84050
T473 84436-84444 Body_part denotes cytokine http://purl.org/sig/ont/fma/fma84050
T474 84676-84681 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T475 84862-84867 Body_part denotes organ http://purl.org/sig/ont/fma/fma67498
T476 84943-84951 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T477 85228-85233 Body_part denotes blood http://purl.org/sig/ont/fma/fma9670
T478 85297-85302 Body_part denotes Organ http://purl.org/sig/ont/fma/fma67498
T479 85664-85672 Body_part denotes antibody http://purl.org/sig/ont/fma/fma62871
T480 85774-85779 Body_part denotes blood http://purl.org/sig/ont/fma/fma9670
T481 85950-85956 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T482 86037-86043 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T483 86455-86460 Body_part denotes blood http://purl.org/sig/ont/fma/fma9670
T484 86606-86622 Body_part denotes surface of cells http://purl.org/sig/ont/fma/fma67653
T485 86617-86622 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T486 86872-86878 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T487 87003-87009 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T488 87081-87087 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T489 87454-87460 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T490 87683-87687 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T491 87968-87974 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T492 88045-88063 Body_part denotes pulmonary arterial http://purl.org/sig/ont/fma/fma66326
T493 88275-88279 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T494 88691-88695 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T495 89276-89282 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T496 89784-89790 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T497 90110-90115 Body_part denotes blood http://purl.org/sig/ont/fma/fma9670
T498 90187-90193 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T499 90328-90334 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T500 92838-92844 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T501 93250-93256 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T502 93443-93449 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T503 94213-94219 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T504 94585-94591 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T505 95308-95314 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T506 95347-95353 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T507 95414-95429 Body_part denotes coronary artery http://purl.org/sig/ont/fma/fma49893
T508 95607-95612 Body_part denotes blood http://purl.org/sig/ont/fma/fma9670
T509 95811-95817 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T510 96351-96355 Body_part denotes axis http://purl.org/sig/ont/fma/fma12520
T511 97245-97249 Body_part denotes face http://purl.org/sig/ont/fma/fma24728
T512 98446-98451 Body_part denotes lungs http://purl.org/sig/ont/fma/fma68877
T513 98595-98603 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T514 99530-99537 Body_part denotes insulin http://purl.org/sig/ont/fma/fma83365

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 68-92 Body_part denotes Renin-Angiotensin System http://purl.obolibrary.org/obo/UBERON_0018229
T2 193-217 Body_part denotes renin-angiotensin system http://purl.obolibrary.org/obo/UBERON_0018229
T3 219-222 Body_part denotes RAS http://purl.obolibrary.org/obo/UBERON_0018229
T4 389-392 Body_part denotes RAS http://purl.obolibrary.org/obo/UBERON_0018229
T5 873-897 Body_part denotes renin-angiotensin system http://purl.obolibrary.org/obo/UBERON_0018229
T6 3795-3801 Body_part denotes kidney http://purl.obolibrary.org/obo/UBERON_0002113
T7 4249-4253 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T8 4444-4448 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T9 4641-4650 Body_part denotes epithelia http://purl.obolibrary.org/obo/UBERON_0000483
T10 5245-5254 Body_part denotes epithelia http://purl.obolibrary.org/obo/UBERON_0000483
T11 7305-7325 Body_part denotes bronchial epithelium http://purl.obolibrary.org/obo/UBERON_0002031
T12 7315-7325 Body_part denotes epithelium http://purl.obolibrary.org/obo/UBERON_0000483
T13 7714-7718 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T14 8939-8943 Body_part denotes hand http://purl.obolibrary.org/obo/UBERON_0002398
T15 9011-9015 Body_part denotes hand http://purl.obolibrary.org/obo/UBERON_0002398
T16 10031-10035 Body_part denotes neck http://purl.obolibrary.org/obo/UBERON_0000974
T17 10089-10094 Body_part denotes helix http://purl.obolibrary.org/obo/UBERON_0002488
T18 10250-10254 Body_part denotes neck http://purl.obolibrary.org/obo/UBERON_0000974
T19 11669-11675 Body_part denotes organs http://purl.obolibrary.org/obo/UBERON_0000062
T20 11839-11845 Body_part denotes sputum http://purl.obolibrary.org/obo/UBERON_0007311
T21 12803-12807 Body_part denotes hand http://purl.obolibrary.org/obo/UBERON_0002398
T22 13918-13942 Body_part denotes renin-angiotensin system http://purl.obolibrary.org/obo/UBERON_0018229
T23 13944-13947 Body_part denotes RAS http://purl.obolibrary.org/obo/UBERON_0018229
T24 14891-14895 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T25 15467-15471 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T26 15489-15495 Body_part denotes Tissue http://purl.obolibrary.org/obo/UBERON_0000479
T27 15496-15501 Body_part denotes organ http://purl.obolibrary.org/obo/UBERON_0000062
T28 15855-15860 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T29 16225-16230 Body_part denotes heart http://purl.obolibrary.org/obo/UBERON_0000948
T30 16600-16615 Body_part denotes coronary artery http://purl.obolibrary.org/obo/UBERON_0001621
T31 16609-16615 Body_part denotes artery http://purl.obolibrary.org/obo/UBERON_0001637
T32 16767-16777 Body_part denotes myocardium http://purl.obolibrary.org/obo/UBERON_0002349
T33 16917-16922 Body_part denotes heart http://purl.obolibrary.org/obo/UBERON_0000948
T34 18254-18264 Body_part denotes parenchyma http://purl.obolibrary.org/obo/UBERON_0000353
T35 18510-18515 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T36 18708-18724 Body_part denotes pulmonary artery http://purl.obolibrary.org/obo/UBERON_0002012
T37 18718-18724 Body_part denotes artery http://purl.obolibrary.org/obo/UBERON_0001637
T38 18775-18778 Body_part denotes RAS http://purl.obolibrary.org/obo/UBERON_0018229
T39 18992-19003 Body_part denotes endothelium http://purl.obolibrary.org/obo/UBERON_0001986
T40 19091-19096 Body_part denotes heart http://purl.obolibrary.org/obo/UBERON_0000948
T41 19156-19159 Body_part denotes RAS http://purl.obolibrary.org/obo/UBERON_0018229
T42 19331-19334 Body_part denotes RAS http://purl.obolibrary.org/obo/UBERON_0018229
T43 20556-20560 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T44 20773-20776 Body_part denotes RAS http://purl.obolibrary.org/obo/UBERON_0018229
T45 21209-21214 Body_part denotes heart http://purl.obolibrary.org/obo/UBERON_0000948
T46 21555-21559 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T47 21678-21682 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T48 21814-21818 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T49 22039-22043 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T50 22464-22468 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T51 22662-22666 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T52 22804-22808 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T53 23012-23016 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T54 24820-24823 Body_part denotes RAS http://purl.obolibrary.org/obo/UBERON_0018229
T55 26585-26588 Body_part denotes RAS http://purl.obolibrary.org/obo/UBERON_0018229
T56 27170-27173 Body_part denotes RAS http://purl.obolibrary.org/obo/UBERON_0018229
T57 27653-27656 Body_part denotes RAS http://purl.obolibrary.org/obo/UBERON_0018229
T58 29595-29599 Body_part denotes tail http://purl.obolibrary.org/obo/UBERON_0002415
T59 30140-30144 Body_part denotes hand http://purl.obolibrary.org/obo/UBERON_0002398
T60 30194-30198 Body_part denotes hand http://purl.obolibrary.org/obo/UBERON_0002398
T61 30390-30414 Body_part denotes renin–angiotensin system http://purl.obolibrary.org/obo/UBERON_0018229
T62 31026-31030 Body_part denotes hand http://purl.obolibrary.org/obo/UBERON_0002398
T63 31080-31084 Body_part denotes hand http://purl.obolibrary.org/obo/UBERON_0002398
T64 31093-31106 Body_part denotes immune system http://purl.obolibrary.org/obo/UBERON_0002405
T65 31645-31649 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T66 31751-31754 Body_part denotes RAS http://purl.obolibrary.org/obo/UBERON_0018229
T67 32109-32112 Body_part denotes RAS http://purl.obolibrary.org/obo/UBERON_0018229
T68 32225-32230 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T69 32473-32477 Body_part denotes hand http://purl.obolibrary.org/obo/UBERON_0002398
T70 32679-32683 Body_part denotes hand http://purl.obolibrary.org/obo/UBERON_0002398
T71 32790-32794 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T72 33024-33030 Body_part denotes organs http://purl.obolibrary.org/obo/UBERON_0000062
T73 33519-33522 Body_part denotes RAS http://purl.obolibrary.org/obo/UBERON_0018229
T74 33768-33771 Body_part denotes RAS http://purl.obolibrary.org/obo/UBERON_0018229
T75 33909-33912 Body_part denotes RAS http://purl.obolibrary.org/obo/UBERON_0018229
T76 34715-34718 Body_part denotes RAS http://purl.obolibrary.org/obo/UBERON_0018229
T77 35195-35198 Body_part denotes RAS http://purl.obolibrary.org/obo/UBERON_0018229
T78 35228-35231 Body_part denotes RAS http://purl.obolibrary.org/obo/UBERON_0018229
T79 36527-36532 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T80 36959-36964 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T81 37393-37398 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T82 37415-37420 Body_part denotes heart http://purl.obolibrary.org/obo/UBERON_0000948
T83 37870-37881 Body_part denotes vasculature http://purl.obolibrary.org/obo/UBERON_0002049
T84 38060-38063 Body_part denotes RAS http://purl.obolibrary.org/obo/UBERON_0018229
T85 38597-38600 Body_part denotes RAS http://purl.obolibrary.org/obo/UBERON_0018229
T86 38782-38787 Body_part denotes heart http://purl.obolibrary.org/obo/UBERON_0000948
T87 38798-38803 Body_part denotes liver http://purl.obolibrary.org/obo/UBERON_0002107
T88 38805-38810 Body_part denotes colon http://purl.obolibrary.org/obo/UBERON_0001155
T89 38812-38827 Body_part denotes small intestine http://purl.obolibrary.org/obo/UBERON_0002108
T90 38818-38827 Body_part denotes intestine http://purl.obolibrary.org/obo/UBERON_0000160
T91 38829-38833 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T92 38835-38840 Body_part denotes brain http://purl.obolibrary.org/obo/UBERON_0000955
T93 38936-38947 Body_part denotes endothelium http://purl.obolibrary.org/obo/UBERON_0001986
T94 39147-39160 Body_part denotes renal tubules http://purl.obolibrary.org/obo/UBERON_0009773
T95 39162-39166 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T96 41915-41920 Body_part denotes serum http://purl.obolibrary.org/obo/UBERON_0001977
T97 42126-42131 Body_part denotes serum http://purl.obolibrary.org/obo/UBERON_0001977
T98 42633-42638 Body_part denotes serum http://purl.obolibrary.org/obo/UBERON_0001977
T99 42845-42848 Body_part denotes RAS http://purl.obolibrary.org/obo/UBERON_0018229
T100 42943-42949 Body_part denotes kidney http://purl.obolibrary.org/obo/UBERON_0002113
T101 44227-44230 Body_part denotes RAS http://purl.obolibrary.org/obo/UBERON_0018229
T102 45339-45344 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T103 45552-45570 Body_part denotes pulmonary arterial http://purl.obolibrary.org/obo/UBERON_0002012
T104 47079-47083 Body_part denotes hand http://purl.obolibrary.org/obo/UBERON_0002398
T105 47558-47563 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T106 48391-48396 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T107 48406-48411 Body_part denotes serum http://purl.obolibrary.org/obo/UBERON_0001977
T108 48507-48511 Body_part denotes hand http://purl.obolibrary.org/obo/UBERON_0002398
T109 48715-48727 Body_part denotes blood plasma http://purl.obolibrary.org/obo/UBERON_0001969
T110 48715-48720 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T111 49671-49676 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T112 50400-50404 Body_part denotes hand http://purl.obolibrary.org/obo/UBERON_0002398
T113 52245-52248 Body_part denotes RAS http://purl.obolibrary.org/obo/UBERON_0018229
T114 52264-52268 Body_part denotes hand http://purl.obolibrary.org/obo/UBERON_0002398
T115 52755-52760 Body_part denotes serum http://purl.obolibrary.org/obo/UBERON_0001977
T116 53046-53051 Body_part denotes liver http://purl.obolibrary.org/obo/UBERON_0002107
T117 53301-53319 Body_part denotes pulmonary arteries http://purl.obolibrary.org/obo/UBERON_0002012
T118 53577-53581 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T119 53632-53636 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T120 54362-54367 Body_part denotes shell http://purl.obolibrary.org/obo/UBERON_0006612
T121 55361-55365 Body_part denotes hand http://purl.obolibrary.org/obo/UBERON_0002398
T122 58807-58812 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T123 58947-58952 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T124 59306-59311 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T125 59432-59444 Body_part denotes baroreceptor http://purl.obolibrary.org/obo/UBERON_0004019
T126 60186-60190 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T127 61322-61327 Body_part denotes heart http://purl.obolibrary.org/obo/UBERON_0000948
T128 61329-61333 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T129 61335-61340 Body_part denotes liver http://purl.obolibrary.org/obo/UBERON_0002107
T130 61342-61347 Body_part denotes colon http://purl.obolibrary.org/obo/UBERON_0001155
T131 61365-61371 Body_part denotes organs http://purl.obolibrary.org/obo/UBERON_0000062
T132 61396-61401 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T133 63326-63331 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T134 65559-65562 Body_part denotes RAS http://purl.obolibrary.org/obo/UBERON_0018229
T135 66130-66142 Body_part denotes renal artery http://purl.obolibrary.org/obo/UBERON_0001184
T136 66136-66142 Body_part denotes artery http://purl.obolibrary.org/obo/UBERON_0001637
T137 66493-66496 Body_part denotes RAS http://purl.obolibrary.org/obo/UBERON_0018229
T138 66572-66575 Body_part denotes RAS http://purl.obolibrary.org/obo/UBERON_0018229
T139 73324-73340 Body_part denotes pulmonary artery http://purl.obolibrary.org/obo/UBERON_0002012
T140 73334-73340 Body_part denotes artery http://purl.obolibrary.org/obo/UBERON_0001637
T141 75176-75180 Body_part denotes face http://purl.obolibrary.org/obo/UBERON_0001456
T142 75761-75765 Body_part denotes hand http://purl.obolibrary.org/obo/UBERON_0002398
T143 75831-75836 Body_part denotes urine http://purl.obolibrary.org/obo/UBERON_0001088
T144 76253-76257 Body_part denotes hand http://purl.obolibrary.org/obo/UBERON_0002398
T145 76463-76468 Body_part denotes heart http://purl.obolibrary.org/obo/UBERON_0000948
T146 77727-77733 Body_part denotes kidney http://purl.obolibrary.org/obo/UBERON_0002113
T147 77971-77976 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T148 78019-78025 Body_part denotes kidney http://purl.obolibrary.org/obo/UBERON_0002113
T149 78268-78273 Body_part denotes urine http://purl.obolibrary.org/obo/UBERON_0001088
T150 78600-78605 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T151 78705-78708 Body_part denotes RAS http://purl.obolibrary.org/obo/UBERON_0018229
T152 78951-78956 Body_part denotes organ http://purl.obolibrary.org/obo/UBERON_0000062
T153 79522-79526 Body_part denotes hand http://purl.obolibrary.org/obo/UBERON_0002398
T154 80224-80227 Body_part denotes RAS http://purl.obolibrary.org/obo/UBERON_0018229
T155 80961-80964 Body_part denotes RAS http://purl.obolibrary.org/obo/UBERON_0018229
T156 81005-81008 Body_part denotes RAS http://purl.obolibrary.org/obo/UBERON_0018229
T157 81060-81065 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T158 82404-82407 Body_part denotes RAS http://purl.obolibrary.org/obo/UBERON_0018229
T159 83194-83198 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T160 83548-83552 Body_part denotes hand http://purl.obolibrary.org/obo/UBERON_0002398
T161 83647-83652 Body_part denotes serum http://purl.obolibrary.org/obo/UBERON_0001977
T162 84789-84792 Body_part denotes RAS http://purl.obolibrary.org/obo/UBERON_0018229
T163 84862-84867 Body_part denotes organ http://purl.obolibrary.org/obo/UBERON_0000062
T164 85228-85233 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T165 85297-85302 Body_part denotes Organ http://purl.obolibrary.org/obo/UBERON_0000062
T166 85774-85779 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T167 85931-85934 Body_part denotes RAS http://purl.obolibrary.org/obo/UBERON_0018229
T168 86455-86460 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T169 86630-86636 Body_part denotes organs http://purl.obolibrary.org/obo/UBERON_0000062
T170 87683-87687 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T171 87952-87955 Body_part denotes RAS http://purl.obolibrary.org/obo/UBERON_0018229
T172 88045-88063 Body_part denotes pulmonary arterial http://purl.obolibrary.org/obo/UBERON_0002012
T173 88182-88185 Body_part denotes RAS http://purl.obolibrary.org/obo/UBERON_0018229
T174 88275-88279 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T175 88611-88614 Body_part denotes RAS http://purl.obolibrary.org/obo/UBERON_0018229
T176 88691-88695 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T177 89813-89816 Body_part denotes RAS http://purl.obolibrary.org/obo/UBERON_0018229
T178 90039-90042 Body_part denotes RAS http://purl.obolibrary.org/obo/UBERON_0018229
T179 90110-90115 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T180 90131-90134 Body_part denotes RAS http://purl.obolibrary.org/obo/UBERON_0018229
T181 90443-90446 Body_part denotes RAS http://purl.obolibrary.org/obo/UBERON_0018229
T182 90552-90555 Body_part denotes RAS http://purl.obolibrary.org/obo/UBERON_0018229
T183 91507-91510 Body_part denotes RAS http://purl.obolibrary.org/obo/UBERON_0018229
T184 92070-92073 Body_part denotes RAS http://purl.obolibrary.org/obo/UBERON_0018229
T185 92564-92567 Body_part denotes RAS http://purl.obolibrary.org/obo/UBERON_0018229
T186 94105-94108 Body_part denotes RAS http://purl.obolibrary.org/obo/UBERON_0018229
T187 94188-94191 Body_part denotes RAS http://purl.obolibrary.org/obo/UBERON_0018229
T188 94502-94505 Body_part denotes RAS http://purl.obolibrary.org/obo/UBERON_0018229
T189 95414-95429 Body_part denotes coronary artery http://purl.obolibrary.org/obo/UBERON_0001621
T190 95423-95429 Body_part denotes artery http://purl.obolibrary.org/obo/UBERON_0001637
T191 95607-95612 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T192 95834-95837 Body_part denotes RAS http://purl.obolibrary.org/obo/UBERON_0018229
T193 97245-97249 Body_part denotes face http://purl.obolibrary.org/obo/UBERON_0001456
T194 97870-97873 Body_part denotes RAS http://purl.obolibrary.org/obo/UBERON_0018229
T195 100124-100139 Body_part denotes digestive tract http://purl.obolibrary.org/obo/UBERON_0001555
T196 100629-100634 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T197 101062-101066 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T198 101223-101227 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T199 101295-101312 Body_part denotes respiratory tract http://purl.obolibrary.org/obo/UBERON_0000065
T200 101825-101828 Body_part denotes RAS http://purl.obolibrary.org/obo/UBERON_0018229
T201 102318-102322 Body_part denotes face http://purl.obolibrary.org/obo/UBERON_0001456
T202 102356-102360 Body_part denotes hand http://purl.obolibrary.org/obo/UBERON_0002398
T203 102740-102745 Body_part denotes heart http://purl.obolibrary.org/obo/UBERON_0000948
T204 102746-102750 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T205 102751-102756 Body_part denotes liver http://purl.obolibrary.org/obo/UBERON_0002107
T206 102757-102766 Body_part denotes intestine http://purl.obolibrary.org/obo/UBERON_0000160
T207 102767-102773 Body_part denotes kidney http://purl.obolibrary.org/obo/UBERON_0002113
T208 102774-102787 Body_part denotes immune system http://purl.obolibrary.org/obo/UBERON_0002405
T209 102788-102793 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T210 102935-102940 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T211 103182-103186 Body_part denotes face http://purl.obolibrary.org/obo/UBERON_0001456
T212 103408-103411 Body_part denotes RAS http://purl.obolibrary.org/obo/UBERON_0018229
T213 103754-103758 Body_part denotes face http://purl.obolibrary.org/obo/UBERON_0001456
T214 103926-103929 Body_part denotes RAS http://purl.obolibrary.org/obo/UBERON_0018229
T215 104521-104524 Body_part denotes RAS http://purl.obolibrary.org/obo/UBERON_0018229
T216 105117-105120 Body_part denotes RAS http://purl.obolibrary.org/obo/UBERON_0018229
T217 105476-105479 Body_part denotes RAS http://purl.obolibrary.org/obo/UBERON_0018229
T218 105777-105792 Body_part denotes coronary artery http://purl.obolibrary.org/obo/UBERON_0001621
T219 105786-105792 Body_part denotes artery http://purl.obolibrary.org/obo/UBERON_0001637
T220 105855-105858 Body_part denotes RAS http://purl.obolibrary.org/obo/UBERON_0018229
T221 106014-106019 Body_part denotes heart http://purl.obolibrary.org/obo/UBERON_0000948
T222 107834-107839 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T223 108207-108211 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T224 108212-108218 Body_part denotes tissue http://purl.obolibrary.org/obo/UBERON_0000479
T225 109337-109341 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T226 110923-110928 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T227 110990-110993 Body_part denotes RAS http://purl.obolibrary.org/obo/UBERON_0018229
T228 111708-111711 Body_part denotes RAS http://purl.obolibrary.org/obo/UBERON_0018229
T229 112185-112188 Body_part denotes RAS http://purl.obolibrary.org/obo/UBERON_0018229
T230 113188-113192 Body_part denotes face http://purl.obolibrary.org/obo/UBERON_0001456
T231 113864-113888 Body_part denotes renin-angiotensin system http://purl.obolibrary.org/obo/UBERON_0018229
T232 113971-113974 Body_part denotes RAS http://purl.obolibrary.org/obo/UBERON_0018229
T233 114027-114030 Body_part denotes RAS http://purl.obolibrary.org/obo/UBERON_0018229
T234 114100-114103 Body_part denotes RAS http://purl.obolibrary.org/obo/UBERON_0018229
T235 114215-114218 Body_part denotes RAS http://purl.obolibrary.org/obo/UBERON_0018229

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
4 20-23 Gene denotes ACE Gene:59272
5 24-28 Gene denotes ACE2 Gene:59272
6 68-73 Gene denotes Renin Gene:5972
7 107-115 Disease denotes COVID-19 MESH:C000657245
21 517-520 Gene denotes ACE Gene:59272
22 525-529 Gene denotes ACE2 Gene:59272
23 663-668 Gene denotes renin Gene:5972
24 873-878 Gene denotes renin Gene:5972
25 256-264 Species denotes patients Tax:9606
26 277-287 Species denotes SARS-CoV-2 Tax:2697049
27 441-447 Species denotes humans Tax:9606
28 594-602 Species denotes patients Tax:9606
29 776-786 Species denotes SARS-CoV-2 Tax:2697049
30 636-641 Chemical denotes metal MESH:D008670
31 265-273 Disease denotes infected MESH:D007239
32 585-593 Disease denotes COVID-19 MESH:C000657245
33 817-824 Disease denotes hypoxia MESH:D000860
88 2094-2099 Gene denotes IL-1β Gene:3552
89 2101-2105 Gene denotes IL-6 Gene:3569
90 2107-2111 Gene denotes IL-8 Gene:3576
91 2113-2118 Gene denotes IL-10 Gene:3586
92 2123-2127 Gene denotes TNFα Gene:7124
93 1011-1058 Species denotes severe acute respiratory syndrome coronavirus 2 Tax:2697049
94 1060-1070 Species denotes SARS-CoV-2 Tax:2697049
95 1260-1268 Species denotes patients Tax:9606
96 1679-1687 Species denotes patients Tax:9606
97 1711-1719 Species denotes patients Tax:9606
98 2394-2402 Species denotes patients Tax:9606
99 2452-2460 Species denotes patients Tax:9606
100 2817-2824 Species denotes patient Tax:9606
101 2857-2865 Species denotes patients Tax:9606
102 3313-3321 Species denotes patients Tax:9606
103 3606-3614 Species denotes patients Tax:9606
104 3810-3818 Species denotes patients Tax:9606
105 3866-3874 Species denotes patients Tax:9606
106 3323-3326 Gene denotes Th2 Gene:15111
107 1307-1313 Chemical denotes oxygen MESH:D010100
108 1365-1376 Chemical denotes chloroquine MESH:D002738
109 1382-1392 Chemical denotes macrolides MESH:D018942
110 1072-1081 Disease denotes infection MESH:D007239
111 1102-1110 Disease denotes COVID-19 MESH:C000657245
112 1240-1248 Disease denotes COVID-19 MESH:C000657245
113 1249-1258 Disease denotes infection MESH:D007239
114 1426-1446 Disease denotes SARS-CoV-2 infection MESH:C000657245
115 1549-1575 Disease denotes acute respiratory syndrome MESH:D012120
116 1598-1603 Disease denotes death MESH:D003643
117 1728-1757 Disease denotes lymphopaenia and eosinopaenia
118 1835-1847 Disease denotes eosinopaenia
119 1948-1974 Disease denotes cardiac dysfunction/injury MESH:D006331
120 1976-2004 Disease denotes respiratory distress/illness MESH:D012140
121 2006-2046 Disease denotes coagulopathy, hypoproteinaemia, acidosis MESH:D000138
122 2048-2055 Disease denotes hypoxia MESH:D000860
123 2163-2175 Disease denotes hypertension MESH:D006973
124 2256-2270 Disease denotes severe disease MESH:D045169
125 2334-2340 Disease denotes asthma MESH:D001249
126 2385-2393 Disease denotes infected MESH:D007239
127 2443-2451 Disease denotes allergic MESH:D004342
128 2555-2561 Disease denotes asthma MESH:D001249
129 2623-2639 Disease denotes Viral infections MESH:D001102
130 2669-2685 Disease denotes allergic disease MESH:D004342
131 2996-3016 Disease denotes hypertensive disease MESH:D006973
132 3107-3122 Disease denotes virus infection MESH:D001102
133 3167-3179 Disease denotes hypertension MESH:D006973
134 3304-3312 Disease denotes infected MESH:D007239
135 3336-3353 Disease denotes allergic diseases MESH:D004342
136 3510-3522 Disease denotes hypertensive MESH:D006973
137 3584-3592 Disease denotes COVID-19 MESH:C000657245
138 3630-3651 Disease denotes chronic renal disease MESH:D051436
139 3787-3809 Disease denotes chronic kidney disease MESH:D051436
140 3843-3851 Disease denotes COVID-19 MESH:C000657245
141 3859-3865 Disease denotes asthma MESH:D001249
145 3880-3884 Gene denotes ACE2 Gene:59272
146 3894-3902 Species denotes SARS-CoV Tax:694009
147 3907-3928 Disease denotes SARS-CoV-2 Infections MESH:C000657245
226 3929-3960 Gene denotes Angiotensin-converting enzyme 2 Gene:59272
227 3962-3966 Gene denotes ACE2 Gene:59272
228 4093-4097 Gene denotes ACE2 Gene:59272
229 4350-4354 Gene denotes ACE2 Gene:70008
230 4488-4492 Gene denotes ACE2 Gene:70008
231 4550-4554 Gene denotes ACE2 Gene:59272
232 4778-4782 Gene denotes ACE2 Gene:59272
233 4832-4838 Gene denotes ADAM17 Gene:6868
234 4912-4916 Gene denotes TNFα Gene:7124
235 4941-4945 Gene denotes ACE2 Gene:59272
236 5027-5032 Gene denotes IL-1β Gene:3552
237 5037-5041 Gene denotes TNFα Gene:7124
238 5179-5183 Gene denotes ACE2 Gene:59272
239 5473-5477 Gene denotes ACE2 Gene:59272
240 5541-5545 Gene denotes ACE2 Gene:59272
241 5622-5628 Gene denotes ADAM17 Gene:6868
242 5629-5633 Gene denotes TACE Gene:6868
243 5643-5647 Gene denotes ACE2 Gene:59272
244 5660-5664 Gene denotes ACE2 Gene:59272
245 5845-5849 Gene denotes ACE2 Gene:59272
246 5885-5889 Gene denotes ACE2 Gene:59272
247 5959-5963 Gene denotes ACE2 Gene:59272
248 6122-6126 Gene denotes ACE2 Gene:59272
249 6416-6421 Gene denotes renin Gene:5972
250 6426-6439 Gene denotes angiotensin I Gene:183
251 6458-6461 Gene denotes ACE Gene:59272
252 6462-6466 Gene denotes ACE2 Gene:59272
253 6573-6577 Gene denotes ACE2 Gene:59272
254 6800-6804 Gene denotes ACE2 Gene:59272
255 7002-7006 Gene denotes ACE2 Gene:59272
256 7167-7171 Gene denotes ACE2 Gene:59272
257 7280-7284 Gene denotes ACE2 Gene:59272
258 7534-7538 Gene denotes ACE2 Gene:59272
259 7549-7553 Gene denotes ACE2 Gene:59272
260 7659-7663 Gene denotes ACE2 Gene:59272
261 7744-7748 Gene denotes ACE2 Gene:59272
262 4726-4731 Gene denotes spike Gene:43740568
263 4302-4307 Gene denotes spike Gene:43740568
264 4005-4010 Gene denotes spike Gene:43740568
265 4026-4034 Species denotes SARS-CoV Tax:694009
266 4272-4280 Species denotes SARS-CoV Tax:694009
267 4458-4462 Species denotes mice Tax:10090
268 4628-4633 Species denotes human Tax:9606
269 5144-5152 Species denotes patients Tax:9606
270 5232-5237 Species denotes human Tax:9606
271 5500-5508 Species denotes SARS-CoV Tax:694009
272 5815-5818 Species denotes CoV Tax:11118
273 6499-6507 Species denotes SARS-CoV Tax:694009
274 6508-6516 Species denotes patients Tax:9606
275 7010-7015 Species denotes human Tax:9606
276 7046-7054 Species denotes SARS-CoV Tax:694009
277 7474-7482 Species denotes patients Tax:9606
278 7515-7525 Species denotes SARS-CoV-2 Tax:2697049
279 7621-7631 Species denotes SARS-CoV-2 Tax:2697049
280 7687-7697 Species denotes SARS-CoV-2 Tax:2697049
281 7779-7787 Species denotes SARS-CoV Tax:694009
282 7604-7609 Gene denotes spike Gene:43740568
283 6623-6628 Gene denotes spike Gene:43740568
284 6529-6534 Gene denotes spike Gene:43740568
285 5862-5867 Gene denotes spike Gene:43740568
286 5483-5488 Gene denotes spike Gene:43740568
287 5381-5386 Gene denotes spike Gene:43740568
288 5343-5348 Gene denotes spike Gene:43740568
289 4992-4997 Gene denotes spike Gene:43740568
290 4330-4332 Chemical denotes 3h MESH:D014316
291 4249-4260 Disease denotes lung injury MESH:D055370
292 4530-4539 Disease denotes infection MESH:D007239
293 5135-5143 Disease denotes COVID-19 MESH:C000657245
294 5742-5757 Disease denotes viral infection MESH:D001102
295 6057-6075 Disease denotes SARS-CoV infection MESH:C000657245
296 6205-6220 Disease denotes viral infection MESH:D001102
297 6342-6370 Disease denotes cardiovascular complications MESH:D002318
298 6381-6392 Disease denotes hypotension MESH:D007022
299 6472-6483 Disease denotes tachycardia MESH:D013610
300 7032-7040 Disease denotes infected MESH:D007239
301 7091-7100 Disease denotes infection MESH:D007239
302 7221-7230 Disease denotes infection MESH:D007239
303 7714-7725 Disease denotes lung injury MESH:D055370
307 7832-7836 Gene denotes ACE2 Gene:59272
308 7868-7872 Gene denotes ACE2 Gene:59272
309 7826-7831 Gene denotes spike Gene:43740568
357 7993-7997 Gene denotes ACE2 Gene:59272
358 8193-8197 Gene denotes ACE2 Gene:59272
359 8348-8381 Gene denotes capsid-distal S1 and –proximal S2
360 8556-8560 Gene denotes ACE2 Gene:59272
361 8728-8732 Gene denotes ACE2 Gene:59272
362 8786-8792 Gene denotes ADAM17 Gene:6868
363 8802-8806 Gene denotes ACE2 Gene:59272
364 8863-8868 Gene denotes furin Gene:5045
365 8954-8958 Gene denotes ACE2 Gene:59272
366 9293-9297 Gene denotes ACE2 Gene:59272
367 9423-9427 Gene denotes ACE2 Gene:59272
368 9498-9503 Gene denotes B0AT1 Gene:340024
369 9520-9524 Gene denotes ACE2 Gene:59272
370 9576-9580 Gene denotes ACE2 Gene:59272
371 9652-9656 Gene denotes ACE2 Gene:59272
372 9689-9693 Gene denotes ACE2 Gene:59272
373 9875-9879 Gene denotes ACE2 Gene:59272
374 9913-9917 Gene denotes ACE2 Gene:59272
375 10129-10133 Gene denotes ACE2 Gene:59272
376 10160-10166 Gene denotes ADAM17 Gene:6868
377 10167-10171 Gene denotes TACE Gene:6868
378 10281-10285 Gene denotes ACE2 Gene:59272
379 10350-10354 Gene denotes ACE2 Gene:59272
380 10409-10413 Gene denotes ACE2 Gene:59272
381 10463-10468 Gene denotes B0AT1 Gene:340024
382 10760-10767 Gene denotes TMPRSS2 Gene:7113
383 10799-10803 Gene denotes ACE2 Gene:59272
384 10793-10798 Gene denotes spike Gene:43740568
385 9624-9629 Gene denotes spike Gene:43740568
386 9546-9551 Gene denotes spike Gene:43740568
387 8906-8911 Gene denotes spike Gene:43740568
388 8445-8450 Gene denotes Spike Gene:43740568
389 8341-8346 Gene denotes spike Gene:43740568
390 8288-8293 Gene denotes spike Gene:43740568
391 8177-8182 Gene denotes spike Gene:43740568
392 8076-8085 Species denotes SARS-CoVs Tax:694009
393 8263-8279 Species denotes SARS coronavirus Tax:694009
394 8464-8469 Species denotes clove Tax:219868
395 9148-9156 Species denotes SARS-CoV Tax:694009
396 9278-9288 Species denotes SARS-CoV-2 Tax:2697049
397 9417-9422 Species denotes human Tax:9606
398 10555-10563 Species denotes SARS-CoV Tax:694009
399 8749-8754 Gene denotes spike Gene:43740568
400 8223-8231 Disease denotes infected MESH:D007239
401 9103-9112 Disease denotes infection MESH:D007239
402 9173-9182 Disease denotes infection MESH:D007239
403 10883-10892 Disease denotes infection MESH:D007239
437 11027-11031 Gene denotes ACE2 Gene:59272
438 11188-11192 Gene denotes ACE2 Gene:59272
439 11299-11303 Gene denotes ACE2 Gene:59272
440 11701-11705 Gene denotes ACE2 Gene:59272
441 12607-12611 Gene denotes ACE2 Gene:59272
442 13068-13072 Gene denotes ACE2 Gene:59272
443 13256-13261 Gene denotes spike Gene:43740568
444 13186-13191 Gene denotes spike Gene:43740568
445 11017-11022 Gene denotes spike Gene:43740568
446 11005-11013 Species denotes patients Tax:9606
447 11365-11375 Species denotes SARS-CoV-2 Tax:2697049
448 11433-11443 Species denotes SARS-CoV-2 Tax:2697049
449 11537-11547 Species denotes SARS-CoV-2 Tax:2697049
450 11855-11863 Species denotes SARS-CoV Tax:694009
451 11864-11872 Species denotes patients Tax:9606
452 12068-12076 Species denotes SARS-CoV Tax:694009
453 12154-12162 Species denotes patients Tax:9606
454 12230-12238 Species denotes patients Tax:9606
455 12418-12426 Species denotes patients Tax:9606
456 12507-12515 Species denotes patients Tax:9606
457 12578-12586 Species denotes children Tax:9606
458 12974-12984 Species denotes SARS-CoV-2 Tax:2697049
459 13139-13149 Species denotes SARS-CoV-2 Tax:2697049
460 13465-13478 Species denotes coronaviruses Tax:11118
461 10987-10995 Disease denotes COVID-19 MESH:C000657245
462 10996-11004 Disease denotes infected MESH:D007239
463 12221-12229 Disease denotes COVID-19 MESH:C000657245
464 12307-12315 Disease denotes COVID-19 MESH:C000657245
465 12390-12407 Disease denotes SARS-CoV infected MESH:C000657245
466 12643-12659 Disease denotes Kawasaki disease MESH:D009080
467 13508-13517 Disease denotes infection MESH:D007239
468 13663-13671 Disease denotes COVID-19 MESH:C000657245
469 13743-13751 Disease denotes COVID-19 MESH:C000657245
471 13801-13805 Gene denotes ACE2 Gene:59272
497 13827-13830 Gene denotes ACE Gene:59272
498 13835-13839 Gene denotes ACE2 Gene:59272
499 13950-13954 Gene denotes ACE2 Gene:59272
500 14100-14110 Gene denotes bradykinin Gene:3827
501 14127-14138 Gene denotes B1 receptor Gene:623
502 14165-14173 Gene denotes Ang (1–9 Gene:284
503 14209-14242 Gene denotes ACE/Ang II/Ang II type 1 receptor Gene:1636
504 14244-14248 Gene denotes AT1R Gene:185
505 14421-14442 Gene denotes nitric oxide synthase Gene:4843
506 14684-14687 Gene denotes ACE Gene:59272
507 14703-14707 Gene denotes ACE2 Gene:59272
508 14748-14752 Gene denotes AT1R Gene:185
509 14978-14982 Gene denotes ACE2 Gene:59272
510 15141-15145 Gene denotes ACE2 Gene:59272
511 15109-15112 Gene denotes ACE Gene:59272
512 14151-14159 Gene denotes Ang (1–7 Gene:284
513 14011-14019 Gene denotes Ang (1–7 Gene:284
514 14366-14369 Gene denotes AT2 Gene:186
515 14741-14747 Gene denotes Ang II Gene:24179
516 14798-14809 Chemical denotes aldosterone MESH:D000450
517 14296-14307 Disease denotes hypotension MESH:D007022
518 14641-14652 Disease denotes dysfunction MESH:D009461
519 14811-14823 Disease denotes inflammation MESH:D007249
520 14855-14865 Disease denotes thrombosis MESH:D013927
521 14867-14886 Disease denotes cardiac dysfunction MESH:D006331
739 15280-15284 Gene denotes ACE2 Gene:59272
740 15613-15617 Gene denotes AT1R Gene:185
741 15756-15768 Gene denotes Mas receptor Gene:116511
742 15770-15774 Gene denotes MasR Gene:116511
743 15803-15811 Gene denotes Ang (1–7 Gene:305843
744 16164-16168 Gene denotes ACE2 Gene:70008
745 16404-16408 Gene denotes ACE2 Gene:70008
746 16674-16678 Gene denotes ACE2 Gene:302668
747 16843-16847 Gene denotes ACE2 Gene:302668
748 17282-17286 Gene denotes AT1R Gene:24180
749 17351-17359 Gene denotes Ang (1–9 Gene:305843
750 17376-17380 Gene denotes AT2R Gene:24182
751 17470-17474 Gene denotes AT2R Gene:24182
752 17500-17504 Gene denotes AT2R Gene:24182
753 17663-17667 Gene denotes AT2R Gene:24182
754 17690-17694 Gene denotes AT1R Gene:11610
755 18094-18098 Gene denotes ACE2 Gene:59272
756 18201-18205 Gene denotes ACE2 Gene:59272
757 18341-18345 Gene denotes ACE2 Gene:59272
758 18374-18378 Gene denotes ACE2 Gene:59272
759 18451-18456 Gene denotes IL-1β Gene:3552
760 18522-18526 Gene denotes CD34 Gene:947
761 18535-18539 Gene denotes MasR Gene:116511
762 18555-18559 Gene denotes ACE2 Gene:59272
763 18780-18783 Gene denotes ACE Gene:59272
764 18788-18792 Gene denotes ACE2 Gene:59272
765 18826-18830 Gene denotes ACE2 Gene:59272
766 18866-18869 Gene denotes ACE Gene:59272
767 18897-18901 Gene denotes AT1R Gene:185
768 18941-18944 Gene denotes ACE Gene:59272
769 18949-18953 Gene denotes ACE2 Gene:59272
770 19195-19198 Gene denotes ACE Gene:59272
771 19203-19207 Gene denotes ACE2 Gene:59272
772 19426-19430 Gene denotes ACE2 Gene:70008
773 19441-19445 Gene denotes MasR Gene:116511
774 19470-19473 Gene denotes ACE Gene:70008
775 19534-19539 Gene denotes Ren-2 Gene:19702
776 19592-19597 Gene denotes Ren-2 Gene:19702
777 19811-19816 Gene denotes renin Gene:24715
778 19859-19862 Gene denotes ACE Gene:302668
779 19866-19870 Gene denotes ACE2 Gene:302668
780 20020-20025 Gene denotes renin Gene:24715
781 20060-20066 Gene denotes Ang II Gene:24179
782 20400-20404 Gene denotes MasR Gene:116511
783 20506-20510 Gene denotes ACE2 Gene:302668
784 20511-20519 Gene denotes Ang (1–7 Gene:305843
785 20805-20810 Gene denotes renin Gene:5972
786 20830-20833 Gene denotes ACE Gene:59272
787 20838-20842 Gene denotes ACE2 Gene:59272
788 20897-20905 Gene denotes Ang (1–9 Gene:284
789 20927-20930 Gene denotes ACE Gene:59272
790 21016-21024 Gene denotes Ang (1–9 Gene:305843
791 21026-21030 Gene denotes AT2R Gene:24182
792 21041-21049 Gene denotes Ang (1–5 Gene:305843
793 21124-21128 Gene denotes MasR Gene:116511
794 21194-21202 Gene denotes Ang (1–5 Gene:305843
795 21371-21375 Gene denotes ACE2 Gene:59272
796 21442-21450 Gene denotes Ang (1–7 Gene:284
797 21482-21485 Gene denotes Bax Gene:581
798 21622-21630 Gene denotes Ang (1–7 Gene:305843
799 21778-21783 Gene denotes TNF-α Gene:24835
800 21788-21792 Gene denotes IL-6 Gene:24498
801 21988-21992 Gene denotes ACE2 Gene:302668
802 22086-22090 Gene denotes MasR Gene:116511
803 22137-22141 Gene denotes ACE2 Gene:302668
804 22257-22261 Gene denotes ACE2 Gene:59272
805 22526-22530 Gene denotes ACE2 Gene:70008
806 22854-22858 Gene denotes ACE2 Gene:70008
807 22871-22879 Gene denotes Ang (1–7 Gene:11727
808 22915-22919 Gene denotes ACE2 Gene:70008
809 22962-22966 Gene denotes ACE2 Gene:70008
810 22995-22999 Gene denotes ACE2 Gene:70008
811 23047-23051 Gene denotes ACE2 Gene:70008
812 23111-23119 Gene denotes Ang (1–7 Gene:11727
813 23434-23438 Gene denotes ACE2 Gene:70008
814 23474-23478 Gene denotes ACE2 Gene:70008
815 23612-23617 Gene denotes IL-10 Gene:16153
816 23677-23682 Gene denotes IL-10 Gene:16153
817 23734-23738 Gene denotes MasR Gene:116511
818 23764-23769 Gene denotes IL-10 Gene:16153
819 23819-23831 Gene denotes AT2 receptor Gene:11609
820 23895-23900 Gene denotes IL-10 Gene:16153
821 24087-24092 Gene denotes IL-10 Gene:16153
822 24353-24358 Gene denotes IL-10 Gene:16153
823 24449-24454 Gene denotes IL-10 Gene:3586
824 24490-24494 Gene denotes ACE2 Gene:59272
825 24631-24635 Gene denotes ACE2 Gene:59272
826 24636-24644 Gene denotes Ang (1–7 Gene:284
827 24666-24671 Gene denotes IL-10 Gene:3586
828 24371-24379 Gene denotes Ang (1–7 Gene:11727
829 23569-23577 Gene denotes Ang (1–7 Gene:11727
830 23270-23278 Gene denotes Ang (1–7 Gene:11727
831 23137-23145 Gene denotes Ang (1–7 Gene:11727
832 22076-22084 Gene denotes Ang (1–7 Gene:305843
833 21339-21347 Gene denotes Ang (1–7 Gene:284
834 20997-21005 Gene denotes Ang (1–7 Gene:305843
835 20953-20961 Gene denotes Ang (1–5 Gene:284
836 20908-20916 Gene denotes Ang (1–7 Gene:284
837 20390-20398 Gene denotes Ang (1–7 Gene:305843
838 19431-19439 Gene denotes Ang (1–7 Gene:11727
839 15687-15695 Gene denotes Ang (1–7 Gene:11727
840 15288-15296 Gene denotes Ang (1–7 Gene:284
841 24146-24149 Gene denotes Th2 Gene:15111
842 16653-16656 Gene denotes MLN Gene:100126231
843 15447-15452 Species denotes human Tax:9606
844 15702-15706 Species denotes mice Tax:10090
845 15907-15911 Species denotes rats Tax:10116
846 16125-16140 Species denotes Transgenic mice Tax:10090
847 16409-16424 Species denotes transgenic mice Tax:10090
848 16555-16558 Species denotes rat Tax:10116
849 17263-17266 Species denotes rat Tax:10116
850 17457-17462 Species denotes mouse Tax:10090
851 18172-18177 Species denotes human Tax:9606
852 18280-18285 Species denotes human Tax:9606
853 18516-18521 Species denotes human Tax:9606
854 19025-19030 Species denotes human Tax:9606
855 19051-19059 Species denotes patients Tax:9606
856 19551-19555 Species denotes rats Tax:10116
857 19586-19591 Species denotes mouse Tax:10090
858 19661-19665 Species denotes rats Tax:10116
859 19732-19736 Species denotes rats Tax:10116
860 20189-20192 Species denotes rat Tax:10116
861 20425-20428 Species denotes rat Tax:10116
862 20713-20721 Species denotes patients Tax:9606
863 21162-21165 Species denotes rat Tax:10116
864 21243-21262 Species denotes Sprague-Dawley rats Tax:10116
865 21297-21305 Species denotes patients Tax:9606
866 21642-21653 Species denotes Wistar rats Tax:10116
867 22236-22246 Species denotes SARS-CoV-2 Tax:2697049
868 22509-22513 Species denotes mice Tax:10090
869 23372-23378 Species denotes murine Tax:10090
870 23783-23788 Species denotes mouse Tax:10090
871 24743-24751 Species denotes patients Tax:9606
872 19540-19550 Species denotes transgenic Tax:10090
873 19701-19706 Gene denotes renin Gene:5972
874 19598-19603 Gene denotes renin Gene:5972
875 22495-22500 Gene denotes spike Gene:43740568
876 23637-23641 Gene denotes MasR Gene:116511
877 23280-23284 Gene denotes MasR Gene:116511
878 21007-21011 Gene denotes MasR Gene:116511
879 22886-22892 Gene denotes Ang II Gene:24179
880 22860-22866 Gene denotes Ang II Gene:24179
881 22515-22521 Gene denotes Ang II Gene:24179
882 20889-20895 Gene denotes Ang II Gene:24179
883 19474-19480 Gene denotes Ang II Gene:24179
884 18879-18885 Gene denotes Ang II Gene:24179
885 17602-17608 Gene denotes Ang II Gene:24179
886 17068-17074 Gene denotes Ang II Gene:24179
887 15606-15612 Gene denotes Ang II Gene:24179
888 16649-16652 Chemical denotes C16
889 17517-17524 Chemical denotes PD12319
890 23855-23867 Chemical denotes nitric oxide MESH:D009569
891 15372-15397 Disease denotes inflammation of the renal MESH:D007249
892 15426-15445 Disease denotes cardiac dysfunction MESH:D006331
893 15453-15462 Disease denotes cirrhosis MESH:D005355
894 15467-15478 Disease denotes lung injury MESH:D055370
895 15479-15487 Disease denotes fibrosis MESH:D005355
896 15871-15890 Disease denotes cardiac hypertrophy MESH:D006332
897 15895-15903 Disease denotes fibrosis MESH:D005355
898 16031-16053 Disease denotes myocardial dysfunction MESH:D009202
899 16201-16223 Disease denotes ventricular arrhythmia MESH:D001145
900 16225-16236 Disease denotes heart block MESH:D006327
901 16238-16261 Disease denotes ventricular tachycardia MESH:D017180
902 16275-16299 Disease denotes ventricular fibrillation MESH:D014693
903 16447-16455 Disease denotes fibrosis MESH:D005355
904 16568-16589 Disease denotes myocardial infarction MESH:D009203
905 16725-16733 Disease denotes fibrosis MESH:D005355
906 16738-16777 Disease denotes hypertrophy of non-infarcted myocardium MESH:D006984
907 16895-16922 Disease denotes myocardial infarction heart MESH:D009203
908 16950-16972 Disease denotes cardiovascular disease MESH:D002318
909 17056-17066 Disease denotes thrombosis MESH:D013927
910 17079-17099 Disease denotes hypercholesterolemia MESH:D006937
911 17142-17152 Disease denotes thrombosis MESH:D013927
912 17315-17325 Disease denotes thrombosis MESH:D013927
913 17329-17349 Disease denotes platelet aggregation MESH:D001791
914 17417-17427 Disease denotes thrombotic MESH:D013927
915 17573-17583 Disease denotes thrombosis MESH:D013927
916 17740-17750 Disease denotes thrombosis MESH:D013927
917 17765-17803 Disease denotes disseminated intravascular coagulation MESH:D004211
918 17823-17866 Disease denotes hypoproteinaemia and deficit of coagulation MESH:D001778
919 17926-17936 Disease denotes renal loss MESH:D051437
920 17953-17964 Disease denotes proteinuria MESH:D011507
921 18178-18199 Disease denotes hepatitis C cirrhosis MESH:D006526
922 18310-18328 Disease denotes hypoxic conditions MESH:D000071069
923 18436-18443 Disease denotes hypoxia MESH:D000860
924 18653-18660 Disease denotes hypoxia MESH:D000860
925 18683-18738 Disease denotes hypoxic conditions human pulmonary artery smooth muscle MESH:D018235
926 19065-19104 Disease denotes ischaemic (local hypoxia) heart disease MESH:D003324
927 19214-19232 Disease denotes hypoxic conditions MESH:D000071069
928 19352-19359 Disease denotes hypoxia MESH:D000860
929 19396-19403 Disease denotes hypoxia MESH:D000860
930 19511-19533 Disease denotes pulmonary hypertensive MESH:D006976
931 19719-19731 Disease denotes hypertensive MESH:D006973
932 19794-19801 Disease denotes hypoxia MESH:D000860
933 19891-19909 Disease denotes hypoxic conditions MESH:D000071069
934 19924-19931 Disease denotes hypoxia MESH:D000860
935 19955-19966 Disease denotes hypercapnia MESH:D006935
936 20097-20117 Disease denotes hypercapnic acidosis MESH:D000138
937 20660-20667 Disease denotes hypoxia MESH:D000860
938 20668-20679 Disease denotes hypercapnia MESH:D006935
939 21311-21337 Disease denotes inflammatory bowel disease MESH:D015212
940 21814-21831 Disease denotes lung inflammation MESH:D011014
941 21835-21853 Disease denotes pulmonary fibrosis MESH:D011658
942 21937-21944 Disease denotes hypoxia MESH:D000860
943 21945-21956 Disease denotes hypercapnia MESH:D006935
944 21958-21965 Disease denotes Hypoxia MESH:D000860
945 22190-22198 Disease denotes COVID-19 MESH:C000657245
946 22374-22389 Disease denotes viral infection MESH:D001102
947 22698-22714 Disease denotes pulmonary oedema MESH:D011654
948 23299-23327 Disease denotes allergic airway inflammation MESH:D007249
949 23388-23394 Disease denotes asthma MESH:D001249
950 23458-23464 Disease denotes asthma MESH:D001249
951 23510-23525 Disease denotes asthma symptoms MESH:D051271
952 24210-24231 Disease denotes allergic inflammation MESH:D007249
953 24569-24577 Disease denotes COVID-19 MESH:C000657245
954 24705-24730 Disease denotes eosinopaenia/lymphopaenia
955 24734-24742 Disease denotes COVID-19 MESH:C000657245
1013 24910-24913 Gene denotes ACE Gene:59272
1014 24926-24930 Gene denotes ACE2 Gene:59272
1015 25203-25206 Gene denotes ACE Gene:302668
1016 25207-25211 Gene denotes ACE2 Gene:302668
1017 25248-25251 Gene denotes ACE Gene:302668
1018 25357-25361 Gene denotes ACE2 Gene:302668
1019 25492-25498 Gene denotes Ang II Gene:24179
1020 25613-25617 Gene denotes ACE2 Gene:302668
1021 25703-25707 Gene denotes ACE2 Gene:302668
1022 25739-25743 Gene denotes AT1R Gene:24180
1023 25865-25873 Gene denotes Ang (1–7 Gene:305843
1024 25918-25922 Gene denotes ACE2 Gene:302668
1025 26034-26042 Gene denotes Ang (1–7 Gene:305843
1026 26065-26069 Gene denotes AT1R Gene:24180
1027 26151-26159 Gene denotes Ang (1–7 Gene:305843
1028 26201-26207 Gene denotes Ang II Gene:24179
1029 26217-26221 Gene denotes ACE2 Gene:302668
1030 26306-26310 Gene denotes ACE2 Gene:302668
1031 26359-26367 Gene denotes Ang (1–7 Gene:305843
1032 26389-26393 Gene denotes ACE2 Gene:302668
1033 26633-26636 Gene denotes ACE Gene:302668
1034 26637-26641 Gene denotes ACE2 Gene:302668
1035 26759-26763 Gene denotes ACE2 Gene:302668
1036 26798-26802 Gene denotes MasR Gene:116511
1037 27052-27056 Gene denotes AT1R Gene:185
1038 27086-27090 Gene denotes MasR Gene:116511
1039 27347-27351 Gene denotes ACE2 Gene:59272
1040 27371-27379 Gene denotes Ang (1–7 Gene:284
1041 27448-27452 Gene denotes ACE2 Gene:59272
1042 27536-27540 Gene denotes ACE2 Gene:59272
1043 25986-25994 Gene denotes Ang-(1–7 Gene:305843
1044 27232-27240 Gene denotes Ang (1–7 Gene:284
1045 27076-27084 Gene denotes Ang (1–7 Gene:284
1046 26788-26796 Gene denotes Ang (1–7 Gene:305843
1047 25479-25487 Gene denotes Ang (1–7 Gene:305843
1048 27564-27569 Gene denotes spike Gene:43740568
1049 27396-27400 Gene denotes MasR Gene:116511
1050 26091-26095 Gene denotes MasR Gene:116511
1051 25962-25966 Gene denotes MasR Gene:116511
1052 24952-24957 Species denotes human Tax:9606
1053 25405-25409 Species denotes rats Tax:10116
1054 25578-25582 Species denotes rats Tax:10116
1055 25824-25827 Species denotes rat Tax:10116
1056 27210-27220 Species denotes SARS-CoV-2 Tax:2697049
1057 27570-27580 Species denotes SARS-CoV-2 Tax:2697049
1058 27242-27248 Gene denotes Ang II Gene:24179
1059 27045-27051 Gene denotes Ang II Gene:24179
1060 26281-26287 Gene denotes Ang II Gene:24179
1061 26058-26064 Gene denotes Ang II Gene:24179
1062 25889-25895 Gene denotes Ang II Gene:24179
1063 25682-25688 Gene denotes Ang II Gene:24179
1064 25584-25590 Gene denotes Ang II Gene:24179
1065 24838-24856 Disease denotes hypoxic conditions MESH:D000071069
1066 25144-25151 Disease denotes hypoxia MESH:D000860
1067 26934-26941 Disease denotes hypoxia MESH:D000860
1068 26942-26962 Disease denotes SARS-CoV-2 infection MESH:C000657245
1069 27134-27152 Disease denotes hypoxic conditions MESH:D000071069
1071 27633-27641 Disease denotes COVID-19 MESH:C000657245
1078 29990-29995 Gene denotes IL-1β Gene:3552
1079 30000-30005 Gene denotes TNF-α Gene:7124
1080 30077-30081 Gene denotes ACE2 Gene:59272
1081 30118-30122 Gene denotes ACE2 Gene:59272
1082 29970-29978 Species denotes SARS-CoV Tax:694009
1083 30160-30175 Disease denotes viral infection MESH:D001102
1097 30427-30432 Gene denotes renin Gene:5972
1098 30434-30437 Gene denotes ACE Gene:59272
1099 30442-30446 Gene denotes ACE2 Gene:59272
1100 30517-30525 Gene denotes Ang (1–9 Gene:284
1101 30528-30536 Gene denotes Ang (1–5 Gene:284
1102 30566-30576 Gene denotes bradykinin Gene:3827
1103 30608-30612 Gene denotes ACE2 Gene:59272
1104 30506-30514 Gene denotes Ang (1–7 Gene:284
1105 30645-30655 Species denotes SARS-CoV-2 Tax:2697049
1106 30390-30395 Gene denotes renin Gene:5972
1107 30498-30504 Gene denotes Ang II Gene:24179
1108 30295-30302 Disease denotes Hypoxia MESH:D000860
1109 30330-30341 Disease denotes hypercapnia MESH:D006935
1119 30667-30671 Gene denotes ACE2 Gene:59272
1120 30779-30782 Gene denotes ACE Gene:59272
1121 30822-30828 Gene denotes Ang II Gene:24179
1122 30835-30839 Gene denotes ACE2 Gene:59272
1123 30862-30870 Gene denotes Ang (1–7 Gene:284
1124 30769-30774 Gene denotes renin Gene:5972
1125 30721-30727 Gene denotes Ang II Gene:24179
1126 30698-30709 Disease denotes hypotensive MESH:D007022
1127 30740-30751 Disease denotes Hypotension MESH:D007022
1136 30888-30896 Gene denotes Ang (1–7 Gene:284
1137 30964-30969 Gene denotes IL-10 Gene:3586
1138 31257-31262 Gene denotes IL-10 Gene:3586
1139 31200-31208 Gene denotes Ang (1–7 Gene:284
1140 30983-31012 Disease denotes eosinopaenia and lymphopaenia
1141 31126-31141 Disease denotes virus infection MESH:D001102
1142 31188-31198 Disease denotes infections MESH:D007239
1143 31342-31362 Disease denotes SARS-CoV-2 infection MESH:C000657245
1152 31368-31376 Gene denotes Ang (1–7 Gene:284
1153 31378-31382 Gene denotes MasR Gene:116511
1154 31403-31407 Gene denotes ACE2 Gene:59272
1155 31519-31523 Gene denotes AT1R Gene:185
1156 31552-31556 Gene denotes ACE2 Gene:59272
1157 31512-31518 Gene denotes Ang II Gene:24179
1158 31469-31475 Gene denotes Ang II Gene:24179
1159 31488-31495 Disease denotes hypoxia MESH:D000860
1164 31586-31594 Gene denotes Ang (1–7 Gene:284
1165 31596-31600 Gene denotes MasR Gene:116511
1166 31621-31640 Disease denotes cardiac dysfunction MESH:D006331
1167 31681-31688 Disease denotes hypoxia MESH:D000860
1175 31773-31777 Gene denotes ACE2 Gene:59272
1176 31885-31889 Gene denotes ACE2 Gene:59272
1177 31937-31945 Gene denotes Ang (1–9 Gene:284
1178 31964-31967 Gene denotes AT2 Gene:186
1179 31838-31844 Gene denotes Ang II Gene:24179
1180 32016-32026 Disease denotes thrombosis MESH:D013927
1181 32037-32055 Disease denotes hypoxic conditions MESH:D000071069
1231 27748-27752 Gene denotes ACE2 Gene:59272
1232 27852-27856 Gene denotes ACE2 Gene:59272
1233 27920-27924 Gene denotes ACE2 Gene:59272
1234 28112-28116 Gene denotes ACE2 Gene:59272
1235 28311-28317 Gene denotes ADAM17 Gene:6868
1236 28318-28322 Gene denotes TACE Gene:6868
1237 28337-28341 Gene denotes ACE2 Gene:59272
1238 28355-28360 Gene denotes TNF-α Gene:7124
1239 28419-28423 Gene denotes ACE2 Gene:59272
1240 28682-28687 Gene denotes TNF-α Gene:7124
1241 28692-28697 Gene denotes IL-1β Gene:3552
1242 28779-28783 Gene denotes ACE2 Gene:59272
1243 28856-28860 Gene denotes ACE2 Gene:59272
1244 28942-28947 Gene denotes TNF-α Gene:7124
1245 28952-28957 Gene denotes IL-1β Gene:3552
1246 29015-29019 Gene denotes ACE2 Gene:59272
1247 29078-29083 Gene denotes IL-1β Gene:3552
1248 29175-29180 Gene denotes TNF-α Gene:7124
1249 29185-29190 Gene denotes IL-1β Gene:3552
1250 29274-29280 Gene denotes ADAM17 Gene:6868
1251 29369-29374 Gene denotes TNF-α Gene:7124
1252 29446-29451 Gene denotes TNF-α Gene:7124
1253 29518-29524 Gene denotes ADAM17 Gene:6868
1254 29525-29529 Gene denotes TACE Gene:6868
1255 29578-29582 Gene denotes ACE2 Gene:59272
1256 29625-29631 Gene denotes ADAM17 Gene:6868
1257 29632-29636 Gene denotes TACE Gene:6868
1258 29809-29813 Gene denotes ACE2 Gene:59272
1259 29818-29823 Gene denotes TNF-α Gene:7124
1260 29863-29867 Gene denotes ACE2 Gene:59272
1261 27902-27907 Gene denotes spike Gene:43740568
1262 27756-27766 Species denotes SARS-CoV-2 Tax:2697049
1263 27868-27876 Species denotes SARS-CoV Tax:694009
1264 27997-28005 Species denotes SARS-CoV Tax:694009
1265 28058-28061 Species denotes CoV Tax:11118
1266 28277-28285 Species denotes SARS-CoV Tax:694009
1267 28292-28295 Species denotes CoV Tax:11118
1268 28535-28545 Species denotes SARS-CoV-2 Tax:2697049
1269 28557-28565 Species denotes SARS-CoV Tax:694009
1270 28735-28745 Species denotes SARS-CoV-2 Tax:2697049
1271 29317-29325 Species denotes SARS-CoV Tax:694009
1272 29713-29721 Species denotes SARS-CoV Tax:694009
1273 28053-28057 Species denotes NL63 Tax:277944
1274 28287-28291 Species denotes NL63 Tax:277944
1275 28578-28583 Gene denotes furin Gene:5045
1276 29838-29843 Gene denotes spike Gene:43740568
1277 28027-28047 Disease denotes respiratory symptoms MESH:D012818
1278 29354-29363 Disease denotes infection MESH:D007239
1279 29411-29429 Disease denotes SARS-CoV infection MESH:C000657245
1302 32123-32127 Gene denotes ACE2 Gene:59272
1303 32161-32165 Gene denotes ACE2 Gene:59272
1304 32479-32483 Gene denotes ACE2 Gene:59272
1305 32542-32546 Gene denotes ACE2 Gene:59272
1306 32700-32704 Gene denotes ACE2 Gene:59272
1307 33196-33204 Gene denotes Ang (1–9 Gene:284
1308 33247-33258 Gene denotes B1 receptor Gene:623
1309 33291-33295 Gene denotes ACE2 Gene:59272
1310 33325-33335 Gene denotes bradykinin Gene:3827
1311 33348-33358 Gene denotes bradykinin Gene:3827
1312 33374-33378 Gene denotes ACE2 Gene:59272
1313 32642-32647 Gene denotes mACE2 Gene:70008
1314 33174-33182 Gene denotes Ang (1–7 Gene:284
1315 32135-32145 Species denotes SARS-CoV-2 Tax:2697049
1316 32602-32612 Species denotes SARS-CoV-2 Tax:2697049
1317 32944-32954 Species denotes SARS-CoV-2 Tax:2697049
1318 33185-33191 Gene denotes Ang II Gene:24179
1319 33314-33321 Chemical denotes des-Arg
1320 33416-33428 Chemical denotes casomorphins
1321 32567-32574 Disease denotes hypoxia MESH:D000860
1322 32575-32586 Disease denotes hypotension MESH:D007022
1323 33138-33146 Disease denotes COVID-19 MESH:C000657245
1329 33881-33888 Gene denotes TMPRSS2 Gene:7113
1330 33893-33899 Gene denotes ADAM17 Gene:6868
1331 33930-33935 Gene denotes renin Gene:5972
1332 33937-33940 Gene denotes ACE Gene:59272
1333 33945-33949 Gene denotes ACE2 Gene:59272
1346 34093-34100 Gene denotes TMPRSS2 Gene:7113
1347 34105-34111 Gene denotes ADAM17 Gene:6868
1348 34172-34179 Gene denotes TMPRSS2 Gene:7113
1349 34333-34339 Gene denotes ADAM17 Gene:6868
1350 34456-34462 Gene denotes ADAM17 Gene:6868
1351 34472-34476 Gene denotes ACE2 Gene:59272
1352 34519-34523 Gene denotes ACE2 Gene:59272
1353 34645-34649 Gene denotes ACE2 Gene:59272
1354 34894-34898 Gene denotes ACE2 Gene:59272
1355 34195-34205 Species denotes SARS-CoV-2 Tax:2697049
1356 34156-34162 Chemical denotes serine MESH:D012694
1357 34779-34787 Disease denotes COVID-19 MESH:C000657245
1367 35293-35297 Gene denotes ACE2 Gene:59272
1368 35343-35346 Gene denotes ACE Gene:59272
1369 35384-35388 Gene denotes MasR Gene:116511
1370 35412-35416 Gene denotes ACE2 Gene:59272
1371 35418-35421 Gene denotes ACE Gene:59272
1372 35426-35431 Gene denotes renin Gene:5972
1373 35571-35575 Gene denotes MasR Gene:116511
1374 35333-35338 Gene denotes renin Gene:5972
1375 35478-35487 Species denotes SARS-CoVs Tax:694009
1422 35815-35823 Gene denotes Ang-(1–7 Gene:284
1423 36034-36042 Gene denotes Ang-(1–7 Gene:284
1424 36122-36126 Gene denotes ACE2 Gene:59272
1425 36226-36230 Gene denotes ACE2 Gene:59272
1426 36335-36339 Gene denotes iNOS Gene:4843
1427 36372-36378 Gene denotes Ang II Gene:24179
1428 36403-36411 Gene denotes Ang (1–7 Gene:284
1429 36594-36599 Gene denotes rACE2 Gene:302668
1430 36780-36788 Gene denotes Ang (1–7 Gene:11727
1431 36794-36798 Gene denotes MasR Gene:116511
1432 37947-37951 Gene denotes ACE2 Gene:59272
1433 35755-35763 Gene denotes Ang-(1–7 Gene:284
1434 35734-35742 Gene denotes Ang-(1–7 Gene:284
1435 36060-36068 Gene denotes Ang (1–5 Gene:284
1436 37906-37910 Gene denotes MasR Gene:116511
1437 37849-37853 Gene denotes MasR Gene:116511
1438 37666-37670 Gene denotes MasR Gene:116511
1439 36455-36459 Gene denotes MasR Gene:116511
1440 36149-36153 Gene denotes MasR Gene:116511
1441 35976-35980 Gene denotes MasR Gene:116511
1442 35897-35901 Gene denotes MasR Gene:116511
1443 35782-35786 Gene denotes MasR Gene:116511
1444 36709-36714 Gene denotes rACE2 Gene:302668
1445 35859-35864 Species denotes human Tax:9606
1446 36249-36254 Species denotes human Tax:9606
1447 36440-36444 Species denotes mice Tax:10090
1448 36862-36866 Species denotes rats Tax:10116
1449 37445-37448 Species denotes rat Tax:10116
1450 37758-37762 Species denotes mice Tax:10090
1451 37766-37770 Species denotes rats Tax:10116
1452 37811-37817 Species denotes humans Tax:9606
1453 37998-38006 Species denotes patients Tax:9606
1454 35683-35695 Gene denotes Mas receptor Gene:116511
1455 35625-35637 Gene denotes Mas receptor Gene:116511
1456 37206-37212 Gene denotes Ang II Gene:24179
1457 37067-37073 Gene denotes Ang II Gene:24179
1458 36734-36740 Gene denotes Ang II Gene:24179
1459 36616-36622 Gene denotes Ang II Gene:24179
1460 36231-36244 Disease denotes hyperactivity MESH:D006948
1461 36563-36574 Disease denotes hypotensive MESH:D007022
1462 36685-36696 Disease denotes hypotensive MESH:D007022
1463 36849-36861 Disease denotes hypertensive MESH:D006973
1464 37075-37087 Disease denotes renal injury MESH:D007674
1465 37458-37476 Disease denotes cardiac arrhythmia MESH:D001145
1466 37566-37576 Disease denotes arrhythmic MESH:D001145
1467 37989-37997 Disease denotes COVID-19 MESH:C000657245
1471 38104-38108 Gene denotes ACE2 Gene:59272
1472 38114-38117 Gene denotes ACE Gene:59272
1473 38119-38132 Disease denotes Hyperactivity MESH:D006948
1488 38165-38169 Gene denotes ACE2 Gene:59272
1489 38174-38177 Gene denotes ACE Gene:59272
1490 38261-38265 Gene denotes ACE2 Gene:59272
1491 38361-38364 Gene denotes ACE Gene:59272
1492 38452-38456 Gene denotes ACE2 Gene:59272
1493 38605-38615 Gene denotes bradykinin Gene:3827
1494 38905-38909 Gene denotes ACE2 Gene:59272
1495 39086-39090 Gene denotes ACE2 Gene:59272
1496 39238-39246 Gene denotes Ang (1–7 Gene:284
1497 39280-39284 Gene denotes MasR Gene:116511
1498 38413-38422 Chemical denotes dipeptide MESH:D004151
1499 38507-38514 Chemical denotes proline MESH:D011392
1500 38734-38745 Disease denotes hypotensive MESH:D007022
1501 39344-39355 Disease denotes hypotension MESH:D007022
1576 39383-39387 Gene denotes ACE2 Gene:59272
1577 39400-39403 Gene denotes ACE Gene:59272
1578 39826-39829 Gene denotes ACE Gene:59272
1579 39834-39838 Gene denotes ACE2 Gene:59272
1580 39867-39875 Gene denotes Ang (1–9 Gene:284
1581 39892-39898 Gene denotes Ang II Gene:24179
1582 39911-39915 Gene denotes ACE2 Gene:59272
1583 39959-39963 Gene denotes ACE2 Gene:59272
1584 40745-40749 Gene denotes ACE2 Gene:59272
1585 42419-42422 Gene denotes ACE Gene:59272
1586 42427-42431 Gene denotes ACE2 Gene:59272
1587 42633-42646 Gene denotes serum albumin Gene:213
1588 43124-43128 Gene denotes ACE2 Gene:59272
1589 43368-43372 Gene denotes ACE2 Gene:59272
1590 40462-40469 Gene denotes albumin Gene:213
1591 43783-43790 Gene denotes albumin Gene:213
1592 43681-43688 Gene denotes albumin Gene:213
1593 43278-43285 Gene denotes albumin Gene:213
1594 42793-42800 Gene denotes albumin Gene:213
1595 42278-42285 Gene denotes albumin Gene:213
1596 41432-41439 Gene denotes albumin Gene:213
1597 41228-41235 Gene denotes albumin Gene:213
1598 41046-41053 Gene denotes albumin Gene:213
1599 40926-40933 Gene denotes albumin Gene:213
1600 40878-40885 Gene denotes albumin Gene:213
1601 40819-40826 Gene denotes albumin Gene:213
1602 40064-40072 Species denotes patients Tax:9606
1603 40266-40274 Species denotes patients Tax:9606
1604 40543-40553 Species denotes SARS-CoV-2 Tax:2697049
1605 41202-41210 Species denotes patients Tax:9606
1606 41384-41392 Species denotes patients Tax:9606
1607 42516-42524 Species denotes patients Tax:9606
1608 42922-42930 Species denotes patients Tax:9606
1609 42958-42966 Species denotes patients Tax:9606
1610 43219-43227 Species denotes patients Tax:9606
1611 43603-43611 Species denotes patients Tax:9606
1612 43715-43723 Species denotes patients Tax:9606
1613 43770-43778 Species denotes patients Tax:9606
1614 41909-41914 Species denotes human Tax:9606
1615 39856-39862 Gene denotes Ang II Gene:24179
1616 41732-41739 Gene denotes albumin Gene:213
1617 39471-39475 Chemical denotes EDTA MESH:D004492
1618 39516-39524 Chemical denotes chloride MESH:D002712
1619 39528-39536 Chemical denotes fluoride MESH:D005459
1620 39595-39603 Chemical denotes chloride MESH:D002712
1621 39784-39792 Chemical denotes chloride MESH:D002712
1622 39933-39941 Chemical denotes chloride MESH:D002712
1623 40074-40082 Chemical denotes chloride MESH:D002712
1624 42165-42170 Chemical denotes metal MESH:D008670
1625 42184-42188 Chemical denotes iron MESH:D007501
1626 42552-42563 Chemical denotes Ang peptide
1627 43467-43471 Chemical denotes Zn2+
1628 43565-43569 Chemical denotes Zn2+
1629 40055-40063 Disease denotes COVID–19 MESH:C000657245
1630 40257-40265 Disease denotes COVID-19 MESH:C000657245
1631 40572-40607 Disease denotes adult respiratory distress syndrome MESH:D012128
1632 40609-40613 Disease denotes ARDS MESH:D012128
1633 40617-40625 Disease denotes COVID-19 MESH:C000657245
1634 40687-40713 Disease denotes inflammatory bowel disease MESH:D015212
1635 40715-40718 Disease denotes IBD MESH:D015212
1636 41197-41201 Disease denotes ARDS MESH:D012128
1637 41305-41321 Disease denotes hypoalbuminaemia
1638 41379-41383 Disease denotes ARDS MESH:D012128
1639 42511-42515 Disease denotes ARDS MESH:D012128
1640 42607-42611 Disease denotes ARDS MESH:D012128
1641 42657-42665 Disease denotes COVID-19 MESH:C000657245
1642 42895-42921 Disease denotes asthmatic/allergic disease MESH:D004342
1643 42935-42957 Disease denotes chronic kidney disease MESH:D051436
1644 42988-43010 Disease denotes cardiovascular disease MESH:D002318
1645 43048-43056 Disease denotes COVID-19 MESH:C000657245
1646 43197-43218 Disease denotes chronic renal disease MESH:D051436
1647 43385-43407 Disease denotes chronic renal diseases MESH:D051436
1648 43596-43602 Disease denotes asthma MESH:D001249
1649 43708-43714 Disease denotes asthma MESH:D001249
1699 44070-44074 Gene denotes ACE2 Gene:59272
1700 44079-44082 Gene denotes ACE Gene:59272
1701 44698-44703 Gene denotes IL-1β Gene:3552
1702 44705-44709 Gene denotes IL-6 Gene:3569
1703 44711-44715 Gene denotes IL-8 Gene:3576
1704 44720-44725 Gene denotes TNF-α Gene:7124
1705 44829-44834 Gene denotes TNF-α Gene:7124
1706 44863-44867 Gene denotes IL-6 Gene:3569
1707 44872-44876 Gene denotes IL-8 Gene:3576
1708 45465-45470 Gene denotes IL-1β Gene:3552
1709 45472-45476 Gene denotes IL-6 Gene:3569
1710 45478-45482 Gene denotes IL-8 Gene:3576
1711 45484-45489 Gene denotes TNF-α Gene:7124
1712 45525-45530 Gene denotes IL-10 Gene:3586
1713 45656-45661 Gene denotes IL-1β Gene:3552
1714 45663-45667 Gene denotes IL-2 Gene:3558
1715 45669-45673 Gene denotes IL-4 Gene:3565
1716 45675-45679 Gene denotes IL-6 Gene:3569
1717 45681-45685 Gene denotes IL-8 Gene:3576
1718 45687-45692 Gene denotes IL-10 Gene:3586
1719 45704-45709 Gene denotes TNF-α Gene:7124
1720 44285-44293 Species denotes patients Tax:9606
1721 44802-44810 Species denotes patients Tax:9606
1722 45601-45609 Species denotes SARS-CoV Tax:694009
1723 43862-43867 Chemical denotes ZnCl2 MESH:C016837
1724 43868-43888 Chemical denotes ZnO/hexachloroethane
1725 44131-44139 Chemical denotes chloride MESH:D002712
1726 44308-44313 Chemical denotes metal MESH:D008670
1727 44563-44573 Chemical denotes metal fume
1728 46182-46187 Chemical denotes ZnCl2 MESH:C016837
1729 43975-43979 Disease denotes ARDS MESH:D012128
1730 44035-44043 Disease denotes COVID-19 MESH:C000657245
1731 44234-44238 Disease denotes ARDS MESH:D012128
1732 44276-44284 Disease denotes COVID-19 MESH:C000657245
1733 44319-44324 Disease denotes fever MESH:D005334
1734 44326-44345 Disease denotes a flu-like syndrome MESH:D007251
1735 44451-44471 Disease denotes respiratory symptoms MESH:D012818
1736 44502-44511 Disease denotes pneumonia MESH:D011014
1737 44574-44579 Disease denotes fever MESH:D005334
1738 44606-44611 Disease denotes fever MESH:D005334
1739 44613-44620 Disease denotes fatigue MESH:D005221
1740 44622-44633 Disease denotes muscle ache MESH:D063806
1741 44635-44640 Disease denotes cough MESH:D003371
1742 44642-44649 Disease denotes dyspnea MESH:D004417
1743 44793-44801 Disease denotes COVID-19 MESH:C000657245
1744 45228-45236 Disease denotes COVID-19 MESH:C000657245
1745 45552-45583 Disease denotes pulmonary arterial hypertension MESH:D000081029
1746 45832-45836 Disease denotes ARDS MESH:D012128
1747 45846-45865 Disease denotes SARS-CoV infections MESH:C000657245
1771 46427-46452 Gene denotes Zrt- and Irt-like protein Gene:84619
1772 46454-46457 Gene denotes ZIP Gene:84619
1773 47796-47801 Gene denotes B0AT1 Gene:340024
1774 47841-47845 Gene denotes ACE2 Gene:59272
1775 47937-47944 Gene denotes insulin Gene:3630
1776 48066-48070 Gene denotes ACE2 Gene:59272
1777 48106-48110 Gene denotes ACE2 Gene:59272
1778 46917-46921 Species denotes rice Tax:4530
1779 47764-47769 Species denotes human Tax:9606
1780 46479-46483 Chemical denotes Zn2+
1781 46494-46498 Chemical denotes Cu2+
1782 46503-46507 Chemical denotes Fe2+
1783 46714-46724 Chemical denotes zinc oxide MESH:D015034
1784 46755-46773 Chemical denotes zinc chloride salt
1785 46945-46955 Chemical denotes folic acid MESH:D005492
1786 47085-47089 Chemical denotes Zn2+
1787 47199-47203 Chemical denotes Zn2+
1788 47232-47237 Chemical denotes amine MESH:D000588
1789 47249-47260 Chemical denotes carboxylate
1790 47366-47376 Chemical denotes ZnCl2 salt
1791 47380-47385 Chemical denotes Zn-AA
1792 47724-47731 Chemical denotes zinc-AA
1793 47877-47884 Chemical denotes zinc-AA
1800 48406-48419 Gene denotes serum albumin Gene:213
1801 48383-48387 Chemical denotes Zn2+
1802 48534-48538 Chemical denotes Zn2+
1803 48579-48583 Chemical denotes Zn2+
1804 48759-48763 Chemical denotes Zn2+
1805 48904-48908 Chemical denotes Zn2+
1875 49159-49162 Gene denotes ZIP Gene:84619
1876 50369-50372 Gene denotes ZIP Gene:84619
1877 50528-50531 Gene denotes ZIP Gene:84619
1878 50761-50768 Gene denotes albumin Gene:213
1879 51267-51274 Gene denotes albumin Gene:213
1880 51850-51860 Gene denotes fibrinogen Gene:2244
1881 52303-52310 Gene denotes albumin Gene:213
1882 51657-51664 Gene denotes albumin Gene:213
1883 51567-51574 Gene denotes albumin Gene:213
1884 51205-51212 Gene denotes albumin Gene:213
1885 50932-50939 Gene denotes albumin Gene:213
1886 50182-50190 Species denotes patients Tax:9606
1887 52718-52725 Species denotes patient Tax:9606
1888 53754-53762 Species denotes patients Tax:9606
1889 48979-48984 Chemical denotes metal MESH:D008670
1890 49140-49144 Chemical denotes Zn2+
1891 50224-50228 Chemical denotes Zn2+
1892 50271-50275 Chemical denotes Fe2+
1893 50280-50284 Chemical denotes Cu2+
1894 50340-50345 Chemical denotes metal MESH:D008670
1895 50487-50491 Chemical denotes Fe2+
1896 50519-50523 Chemical denotes Zn2+
1897 50617-50627 Chemical denotes EDTA metal
1898 50806-50811 Chemical denotes metal MESH:D008670
1899 50864-50879 Chemical denotes free fatty acid MESH:D005230
1900 50881-50884 Chemical denotes FFA MESH:D005230
1901 50973-50978 Chemical denotes metal MESH:D008670
1902 51246-51252 Chemical denotes carbon MESH:D002244
1903 51297-51301 Chemical denotes Zn2+
1904 51696-51700 Chemical denotes Zn2+
1905 51785-51789 Chemical denotes Zn2+
1906 51876-51883 Chemical denotes heparin MESH:D006493
1907 52479-52484 Chemical denotes ZnCl2 MESH:C016837
1908 52485-52488 Chemical denotes ZnO MESH:D015034
1909 52489-52505 Chemical denotes hexachloroethane MESH:C010182
1910 49671-49688 Disease denotes blood coagulation MESH:D001778
1911 49774-49797 Disease denotes cardiovascular diseases MESH:D002318
1912 49799-49817 Disease denotes metabolic syndrome MESH:D024821
1913 49819-49831 Disease denotes inflammation MESH:D007249
1914 49845-49851 Disease denotes stress MESH:D000079225
1915 49853-49861 Disease denotes diabetes MESH:D003920
1916 49866-49876 Disease denotes thrombosis MESH:D013927
1917 49993-50012 Disease denotes Alzheimer’s disease MESH:D000544
1918 50017-50036 Disease denotes cardiac dysfunction MESH:D006331
1919 50136-50145 Disease denotes Alzheimer MESH:D000544
1920 50156-50181 Disease denotes neurodegenerative disease MESH:D019636
1921 50451-50459 Disease denotes COVID-19 MESH:C000657245
1922 50680-50685 Disease denotes death MESH:D003643
1923 50707-50733 Disease denotes neurodegenerative diseases MESH:D019636
1924 51338-51350 Disease denotes dyslipidemia MESH:D050171
1925 51450-51456 Disease denotes stress MESH:D000079225
1926 51759-51778 Disease denotes Alzheimer’s disease MESH:D000544
1927 51999-52009 Disease denotes thrombotic MESH:D013927
1928 52320-52323 Disease denotes IBD MESH:D015212
1929 52325-52329 Disease denotes ARDS MESH:D012128
1930 52334-52342 Disease denotes COVID-19 MESH:C000657245
1931 52434-52438 Disease denotes ARDS MESH:D012128
1932 52685-52689 Disease denotes ARDS MESH:D012128
1933 52784-52788 Disease denotes ARDS MESH:D012128
1934 52803-52808 Disease denotes death MESH:D003643
1935 52814-52832 Disease denotes multiorgan failure MESH:D009102
1936 52860-52875 Disease denotes hepatic failure MESH:D017093
1937 53087-53092 Disease denotes death MESH:D003643
1938 53104-53123 Disease denotes respiratory failure MESH:D012131
1939 53357-53385 Disease denotes acute pulmonary hypertension MESH:D006976
1940 53432-53440 Disease denotes fibrosis MESH:D005355
1941 53529-53537 Disease denotes coughing MESH:D003371
1942 53542-53549 Disease denotes dyspnea MESH:D004417
1943 53745-53753 Disease denotes COVID-19 MESH:C000657245
1946 53820-53824 Gene denotes ACE2 Gene:59272
1947 53802-53809 Chemical denotes MLN4760 MESH:C486469
1977 53877-53881 Gene denotes ACE2 Gene:59272
1978 54071-54075 Gene denotes ACE2 Gene:59272
1979 54374-54378 Gene denotes ACE2 Gene:59272
1980 54500-54504 Gene denotes ACE2 Gene:59272
1981 54740-54744 Gene denotes ACE2 Gene:59272
1982 54794-54798 Gene denotes ACE2 Gene:59272
1983 54825-54829 Gene denotes ACE2 Gene:59272
1984 54858-54862 Gene denotes ACE2 Gene:59272
1985 54954-54958 Gene denotes ACE2 Gene:59272
1986 55056-55060 Gene denotes ACE2 Gene:59272
1987 55118-55122 Gene denotes ACE2 Gene:59272
1988 55201-55205 Gene denotes ACE2 Gene:59272
1989 55236-55240 Gene denotes ACE2 Gene:59272
1990 55254-55258 Gene denotes ACE2 Gene:59272
1991 55312-55316 Gene denotes ACE2 Gene:59272
1992 55415-55419 Gene denotes ACE2 Gene:59272
1993 55634-55638 Gene denotes ACE2 Gene:59272
1994 55723-55727 Gene denotes ACE2 Gene:59272
1995 55270-55275 Gene denotes spike Gene:43740568
1996 55095-55100 Gene denotes spike Gene:43740568
1997 55002-55007 Gene denotes spike Gene:43740568
1998 54928-54933 Gene denotes spike Gene:43740568
1999 54819-54824 Gene denotes spike Gene:43740568
2000 55659-55662 Gene denotes MLN Gene:4295
2001 54734-54739 Species denotes human Tax:9606
2002 54852-54857 Species denotes human Tax:9606
2003 55798-55803 Gene denotes spike Gene:43740568
2004 55552-55557 Gene denotes spike Gene:43740568
2005 55783-55788 Chemical denotes sACE2
2046 55859-55863 Gene denotes ACE2 Gene:59272
2047 55912-55916 Gene denotes ACE2 Gene:59272
2048 56258-56261 Gene denotes ACE Gene:59272
2049 56797-56801 Gene denotes ACE2 Gene:59272
2050 56995-56999 Gene denotes CD34 Gene:947
2051 57043-57047 Gene denotes ACE2 Gene:59272
2052 57965-57969 Gene denotes ACE2 Gene:59272
2053 58141-58145 Gene denotes ACE2 Gene:59272
2054 58195-58199 Gene denotes ACE2 Gene:59272
2055 58248-58252 Gene denotes ACE2 Gene:59272
2056 58327-58331 Gene denotes ACE2 Gene:59272
2057 57676-57684 Gene denotes Ang (1–7 Gene:284
2058 57513-57516 Gene denotes MLN Gene:4295
2059 57190-57193 Gene denotes MLN Gene:4295
2060 56138-56141 Gene denotes MLN Gene:4295
2061 56930-56935 Gene denotes mACE2 Gene:70008
2062 56816-56821 Gene denotes mACE2 Gene:70008
2063 55853-55858 Species denotes human Tax:9606
2064 55906-55911 Species denotes human Tax:9606
2065 56248-56253 Species denotes human Tax:9606
2066 58273-58278 Species denotes human Tax:9606
2067 57652-57658 Gene denotes Ang II Gene:24179
2068 55819-55826 Chemical denotes MLN4760 MESH:C486469
2069 56265-56271 Chemical denotes rhACE2
2070 56370-56375 Chemical denotes rhACE
2071 56462-56467 Chemical denotes rhACE
2072 56531-56537 Chemical denotes rhACE2
2073 56607-56613 Chemical denotes rhACE2
2074 56640-56646 Chemical denotes rhACE2
2075 56654-56659 Chemical denotes rhACE
2076 57059-57064 Chemical denotes Dx600
2077 57203-57208 Chemical denotes DX600
2078 57255-57264 Chemical denotes disulfide MESH:D004220
2079 57379-57385 Chemical denotes rhACE2
2080 57574-57580 Chemical denotes rhACE2
2081 57638-57644 Chemical denotes rhACE2
2082 57695-57700 Chemical denotes DX600
2083 57744-57750 Chemical denotes rhACE2
2084 57988-57993 Chemical denotes Dx600
2085 57463-57483 Disease denotes hypercapnic acidosis MESH:D000138
2117 58394-58398 Gene denotes ACE2 Gene:59272
2118 58567-58571 Gene denotes ACE2 Gene:59272
2119 58663-58667 Gene denotes ACE2 Gene:59272
2120 58774-58781 Gene denotes Ang 1–7 Gene:284
2121 58832-58836 Gene denotes ACE2 Gene:70008
2122 59209-59213 Gene denotes ACE2 Gene:302668
2123 59483-59487 Gene denotes ACE2 Gene:302668
2124 59570-59574 Gene denotes ACE2 Gene:70008
2125 59608-59611 Gene denotes ACE Gene:70008
2126 58747-58753 Gene denotes Ang II Gene:24179
2127 59580-59583 Gene denotes MLN Gene:69563
2128 58907-58910 Gene denotes MLN Gene:69563
2129 58477-58480 Gene denotes MLN Gene:4295
2130 58355-58358 Gene denotes MLN Gene:4295
2131 59024-59028 Species denotes mice Tax:10090
2132 59081-59085 Species denotes rats Tax:10116
2133 59455-59459 Species denotes rats Tax:10116
2134 59682-59686 Species denotes mice Tax:10090
2135 59057-59067 Species denotes transgenic Tax:10090
2136 59005-59010 Chemical denotes water MESH:D014867
2137 59360-59367 Chemical denotes MLN4760 MESH:C486469
2138 59650-59664 Chemical denotes streptozotocin MESH:D013311
2139 58870-58882 Disease denotes hypertensive MESH:D006973
2140 59068-59080 Disease denotes hypertensive MESH:D006973
2141 59175-59187 Disease denotes hypertensive MESH:D006973
2142 59293-59305 Disease denotes hypertensive MESH:D006973
2143 59512-59523 Disease denotes bradycardia MESH:D001919
2144 59613-59624 Disease denotes albuminuria MESH:D000419
2145 59629-59646 Disease denotes glomerular injury MESH:D007674
2146 59673-59681 Disease denotes diabetic MESH:D003920
2147 59747-59755 Disease denotes diabetic MESH:D003920
2177 59852-59856 Gene denotes ACE2 Gene:59272
2178 60310-60315 Gene denotes rACE2 Gene:302668
2179 60373-60377 Gene denotes ACE2 Gene:59272
2180 61097-61101 Gene denotes ACE2 Gene:302668
2181 61291-61295 Gene denotes ACE2 Gene:302668
2182 61383-61387 Gene denotes ACE2 Gene:302668
2183 61608-61611 Gene denotes ACE Gene:70008
2184 61612-61616 Gene denotes ACE2 Gene:70008
2185 61460-61463 Gene denotes MLN Gene:69563
2186 61155-61158 Gene denotes MLN Gene:100126231
2187 60745-60748 Gene denotes MLN Gene:100126231
2188 60578-60581 Gene denotes MLN Gene:4295
2189 60260-60263 Gene denotes MLN Gene:69563
2190 60019-60023 Species denotes mice Tax:10090
2191 60153-60158 Species denotes mouse Tax:10090
2192 60304-60309 Species denotes human Tax:9606
2193 60551-60556 Species denotes human Tax:9606
2194 60707-60726 Species denotes Sprague-Dawley rats Tax:10116
2195 61523-61528 Species denotes mouse Tax:10090
2196 59826-59831 Chemical denotes DX600
2197 60860-60865 Chemical denotes water MESH:D014867
2198 61440-61446 Chemical denotes GL1001 MESH:C486469
2199 60186-60203 Disease denotes lung inflammation MESH:D011014
2200 60434-60443 Disease denotes mortality MESH:D003643
2201 60673-60694 Disease denotes myocardial infarction MESH:D009203
2202 60935-60944 Disease denotes pressures MESH:D006973
2203 61121-61142 Disease denotes myocardial infarction MESH:D009203
2204 61194-61202 Disease denotes COVID-19 MESH:C000657245
2205 61538-61545 Disease denotes colitis MESH:D003092
2229 61716-61720 Gene denotes ACE2 Gene:59272
2230 61780-61784 Gene denotes ACE2 Gene:59272
2231 61790-61793 Gene denotes ACE Gene:59272
2232 61909-61913 Gene denotes ACE2 Gene:59272
2233 61919-61922 Gene denotes ACE Gene:59272
2234 62003-62007 Gene denotes ACE2 Gene:59272
2235 62305-62316 Gene denotes transferrin Gene:7018
2236 63150-63157 Species denotes patient Tax:9606
2237 61941-61945 Chemical denotes EDTA MESH:D004492
2238 62036-62040 Chemical denotes EDTA MESH:D004492
2239 62089-62093 Chemical denotes Zn2+
2240 62102-62106 Chemical denotes Ca2+ MESH:D000069285
2241 62111-62115 Chemical denotes Fe2+
2242 62157-62161 Chemical denotes Ca2+ MESH:D000069285
2243 62237-62241 Chemical denotes Zn2+
2244 62278-62282 Chemical denotes iron MESH:D007501
2245 62340-62344 Chemical denotes iron MESH:D007501
2246 62451-62456 Chemical denotes metal MESH:D008670
2247 62513-62517 Chemical denotes EDTA MESH:D004492
2248 62531-62535 Chemical denotes Zn2+
2249 62623-62632 Chemical denotes CaNa2EDTA
2250 63104-63113 Chemical denotes CaNa2EDTA
2251 62919-62934 Disease denotes zinc deficiency MESH:C564286
2267 63671-63674 Gene denotes ACE Gene:59272
2268 63678-63682 Gene denotes ACE2 Gene:59272
2269 63818-63821 Gene denotes ACE Gene:59272
2270 63826-63830 Gene denotes ACE2 Gene:59272
2271 63890-63893 Gene denotes ACE Gene:59272
2272 63898-63902 Gene denotes ACE2 Gene:59272
2273 64125-64129 Gene denotes ACE2 Gene:59272
2274 64130-64133 Gene denotes ACE Gene:59272
2275 64234-64238 Gene denotes ACE2 Gene:59272
2276 64473-64477 Gene denotes ACE2 Gene:59272
2277 64444-64447 Gene denotes MLN Gene:4295
2278 63262-63271 Chemical denotes CaNa2EDTA
2279 63409-63413 Chemical denotes iron MESH:D007501
2280 63597-63602 Chemical denotes metal MESH:D008670
2281 64022-64027 Chemical denotes metal MESH:D008670
2295 64817-64827 Gene denotes fibrinogen Gene:2244
2296 64691-64699 Species denotes patients Tax:9606
2297 65280-65288 Species denotes patients Tax:9606
2298 64514-64525 Chemical denotes chloroquine MESH:D002738
2299 64774-64778 Chemical denotes Zn2+
2300 64853-64864 Chemical denotes chloroquine MESH:D002738
2301 65013-65017 Chemical denotes Zn2+
2302 65193-65197 Chemical denotes Zn2+
2303 65325-65336 Chemical denotes chloroquine MESH:D002738
2304 64682-64690 Disease denotes COVID-19 MESH:C000657245
2305 64896-64906 Disease denotes thrombotic MESH:D013927
2306 65242-65252 Disease denotes thrombotic MESH:D013927
2307 65271-65279 Disease denotes COVID-19 MESH:C000657245
2329 66316-66323 Species denotes patient Tax:9606
2330 65658-65663 Chemical denotes metal MESH:D008670
2331 66083-66087 Chemical denotes EDTA MESH:D004492
2332 66279-66284 Chemical denotes metal MESH:D008670
2333 65482-65490 Disease denotes COVID-19 MESH:C000657245
2334 65491-65500 Disease denotes infection MESH:D007239
2335 65533-65540 Disease denotes hypoxia MESH:D000860
2336 65742-65774 Disease denotes fatal renal toxicity and failure MESH:D051437
2337 65776-65804 Disease denotes hepatic toxicity and failure MESH:D056486
2338 65806-65834 Disease denotes gastrointestinal haemorrhage MESH:D006471
2339 65836-65847 Disease denotes arrhythmias MESH:D001145
2340 65849-65855 Disease denotes tetany MESH:D013746
2341 65857-65870 Disease denotes hypocalcaemia
2342 65872-65883 Disease denotes hypotension MESH:D007022
2343 65885-65896 Disease denotes convulsions MESH:D012640
2344 65898-65916 Disease denotes respiratory arrest MESH:D012131
2345 65922-65937 Disease denotes agranulocytosis MESH:D000380
2346 65963-65973 Disease denotes infections MESH:D007239
2347 65978-65983 Disease denotes death MESH:D003643
2348 66029-66043 Disease denotes renal toxicity MESH:D007674
2349 66130-66151 Disease denotes renal artery diseases MESH:D007674
2388 66639-66643 Gene denotes ACE2 Gene:59272
2389 66656-66659 Gene denotes ACE Gene:59272
2390 66821-66825 Gene denotes ACE2 Gene:59272
2391 66936-66940 Gene denotes ACE2 Gene:59272
2392 67196-67200 Gene denotes ACE2 Gene:59272
2393 67219-67222 Gene denotes ACE Gene:59272
2394 67238-67242 Gene denotes ACE2 Gene:59272
2395 67287-67290 Gene denotes ACE Gene:59272
2396 67295-67299 Gene denotes ACE2 Gene:59272
2397 67368-67372 Gene denotes ACE2 Gene:59272
2398 67408-67411 Gene denotes ACE Gene:59272
2399 67572-67576 Gene denotes ACE2 Gene:59272
2400 67625-67629 Gene denotes ACE2 Gene:59272
2401 67728-67732 Gene denotes ACE2 Gene:59272
2402 67848-67852 Gene denotes ACE2 Gene:59272
2403 67876-67880 Gene denotes ACE2 Gene:59272
2404 68005-68009 Gene denotes ACE2 Gene:59272
2405 68132-68136 Gene denotes ACE2 Gene:59272
2406 68477-68485 Gene denotes Ang (1–9 Gene:284
2407 68529-68533 Gene denotes ACE2 Gene:59272
2408 68468-68472 Gene denotes MasR Gene:116511
2409 68458-68466 Gene denotes Ang (1–7 Gene:284
2410 67900-67905 Gene denotes spike Gene:43740568
2411 68078-68081 Gene denotes MLN Gene:4295
2412 67917-67925 Species denotes SARS-CoV Tax:694009
2413 67811-67819 Species denotes SARS-CoV Tax:694009
2414 67486-67502 Chemical denotes basic amino acid MESH:D024361
2415 67642-67650 Chemical denotes agmatine MESH:D000376
2416 67667-67675 Chemical denotes arginine MESH:D001120
2417 67744-67748 Chemical denotes NAAE
2418 67756-67760 Chemical denotes NAAE
2419 67948-67952 Chemical denotes NAAE
2420 67990-67994 Chemical denotes NAAE
2421 68100-68108 Chemical denotes agmatine MESH:D000376
2422 68568-68576 Chemical denotes agmatine MESH:D000376
2423 68665-68673 Chemical denotes agmatine MESH:D000376
2424 68760-68776 Chemical denotes agmatine sulfate
2425 68726-68742 Disease denotes neuropathic pain MESH:D009437
2442 69274-69278 Gene denotes ACE2 Gene:59272
2443 69283-69286 Gene denotes ACE Gene:59272
2444 69093-69100 Species denotes soybean Tax:3847
2445 69762-69767 Species denotes human Tax:9606
2446 69935-69940 Species denotes human Tax:9606
2447 68840-68845 Chemical denotes metal MESH:D008670
2448 68864-68872 Chemical denotes phytates MESH:D010833
2449 68877-68887 Chemical denotes folic acid MESH:D005492
2450 69048-69061 Chemical denotes nicotianamine MESH:C082893
2451 69128-69133 Chemical denotes metal MESH:D008670
2452 69175-69180 Chemical denotes metal MESH:D008670
2453 69190-69203 Chemical denotes Nicotianamine MESH:C082893
2454 69307-69315 Chemical denotes zeolites MESH:D017641
2455 69400-69415 Chemical denotes aluminosilicate MESH:C049037
2456 69631-69636 Chemical denotes water MESH:D014867
2457 69801-69815 Chemical denotes clinoptilolite MESH:C083175
2473 70018-70022 Gene denotes ACE2 Gene:59272
2474 70229-70233 Gene denotes ACE2 Gene:59272
2475 70336-70340 Gene denotes ACE2 Gene:59272
2476 70475-70479 Gene denotes ACE2 Gene:59272
2477 70603-70608 Gene denotes hACE2 Gene:59272
2478 70186-70196 Species denotes SARS-CoV-2 Tax:2697049
2479 70330-70335 Species denotes human Tax:9606
2480 70696-70704 Species denotes patients Tax:9606
2481 70734-70740 Chemical denotes rhACE2
2482 70066-70084 Disease denotes SARS-CoV infection MESH:C000657245
2483 70263-70278 Disease denotes viral infection MESH:D001102
2484 70371-70379 Disease denotes COVID-19 MESH:C000657245
2485 70393-70397 Disease denotes ARDS MESH:D012128
2486 70687-70695 Disease denotes COVID-19 MESH:C000657245
2487 70744-70748 Disease denotes ARDS MESH:D012128
2490 70907-70911 Gene denotes ACE2 Gene:59272
2491 70972-70980 Disease denotes COVID-19 MESH:C000657245
2562 71982-71986 Gene denotes ACE2 Gene:59272
2563 72166-72169 Gene denotes ACE Gene:59272
2564 72296-72300 Gene denotes ACE2 Gene:59272
2565 72535-72539 Gene denotes ACE2 Gene:59272
2566 72659-72663 Gene denotes ACE2 Gene:302668
2567 72749-72757 Gene denotes Ang (1–7 Gene:305843
2568 72938-72941 Gene denotes ACE Gene:302668
2569 72992-72996 Gene denotes ACE2 Gene:302668
2570 73007-73011 Gene denotes MasR Gene:116511
2571 73159-73163 Gene denotes ACE2 Gene:59272
2572 73291-73295 Gene denotes ACE2 Gene:59272
2573 73466-73469 Gene denotes AT1 Gene:185
2574 73479-73483 Gene denotes ACE2 Gene:59272
2575 73594-73598 Gene denotes ACE2 Gene:59272
2576 73697-73701 Gene denotes ACE2 Gene:59272
2577 75316-75320 Gene denotes ACE2 Gene:59272
2578 75332-75338 Gene denotes Ang II Gene:24179
2579 75380-75388 Gene denotes Ang (1–9 Gene:284
2580 75507-75511 Gene denotes ACE2 Gene:59272
2581 75512-75515 Gene denotes ACE Gene:59272
2582 75361-75369 Gene denotes Ang (1–7 Gene:284
2583 72997-73005 Gene denotes Ang (1–7 Gene:305843
2584 71626-71634 Species denotes patients Tax:9606
2585 72134-72142 Species denotes patients Tax:9606
2586 72434-72442 Species denotes patients Tax:9606
2587 72700-72704 Species denotes rats Tax:10116
2588 72841-72845 Species denotes rats Tax:10116
2589 72911-72915 Species denotes rats Tax:10116
2590 73057-73063 Species denotes humans Tax:9606
2591 73318-73323 Species denotes human Tax:9606
2592 73952-73960 Species denotes patients Tax:9606
2593 74153-74161 Species denotes patients Tax:9606
2594 74457-74465 Species denotes patients Tax:9606
2595 74513-74521 Species denotes patients Tax:9606
2596 74873-74881 Species denotes patients Tax:9606
2597 75012-75020 Species denotes patients Tax:9606
2598 75213-75221 Species denotes patients Tax:9606
2599 75273-75281 Species denotes patients Tax:9606
2600 73437-73443 Gene denotes Ang II Gene:24179
2601 71432-71439 Chemical denotes calcium MESH:D002118
2602 72475-72490 Chemical denotes cholecalciferol MESH:D002762
2603 72587-72595 Chemical denotes losartan MESH:D019808
2604 72614-72624 Chemical denotes lisinopril MESH:D017706
2605 74807-74815 Chemical denotes losartan MESH:D019808
2606 71000-71008 Disease denotes COVID-19 MESH:C000657245
2607 71060-71072 Disease denotes hypertension MESH:D006973
2608 71074-71082 Disease denotes diabetes MESH:D003920
2609 71182-71194 Disease denotes hypertensive MESH:D006973
2610 71221-71233 Disease denotes hypertensive MESH:D006973
2611 71316-71328 Disease denotes hypertension MESH:D006973
2612 71888-71900 Disease denotes hypertension MESH:D006973
2613 71902-71910 Disease denotes diabetes MESH:D003920
2614 71912-71924 Disease denotes dyslipidemia MESH:D050171
2615 72062-72074 Disease denotes hypertensive MESH:D006973
2616 72111-72119 Disease denotes COVID-19 MESH:C000657245
2617 72125-72133 Disease denotes diabetic MESH:D003920
2618 73207-73225 Disease denotes hypoxic conditions MESH:D000071069
2619 73616-73634 Disease denotes hypoxic conditions MESH:D000071069
2620 73643-73651 Disease denotes COVID-19 MESH:C000657245
2621 73966-73974 Disease denotes COVID-19 MESH:C000657245
2622 74069-74077 Disease denotes COVID-19 MESH:C000657245
2623 74189-74197 Disease denotes COVID-19 MESH:C000657245
2624 74256-74265 Disease denotes mortality MESH:D003643
2625 74417-74425 Disease denotes COVID-19 MESH:C000657245
2626 74637-74642 Disease denotes death MESH:D003643
2627 74835-74843 Disease denotes COVID-19 MESH:C000657245
2628 74990-75002 Disease denotes hypertensive MESH:D006973
2629 75003-75011 Disease denotes diabetic MESH:D003920
2630 75200-75212 Disease denotes hypertensive MESH:D006973
2631 75264-75272 Disease denotes COVID-19 MESH:C000657245
2728 75692-75696 Gene denotes ACE2 Gene:59272
2729 75777-75781 Gene denotes ACE2 Gene:59272
2730 76205-76209 Gene denotes ACE2 Gene:302668
2731 76387-76391 Gene denotes ACE2 Gene:59272
2732 76567-76571 Gene denotes ACE2 Gene:59272
2733 76798-76802 Gene denotes ACE2 Gene:59272
2734 77047-77051 Gene denotes ACE2 Gene:59272
2735 77134-77138 Gene denotes ACE2 Gene:59272
2736 77265-77269 Gene denotes ACE2 Gene:59272
2737 77327-77331 Gene denotes ACE2 Gene:59272
2738 77844-77848 Gene denotes ACE2 Gene:59272
2739 78545-78549 Gene denotes ACE2 Gene:59272
2740 78565-78568 Gene denotes ACE Gene:59272
2741 78569-78573 Gene denotes ACE2 Gene:59272
2742 78928-78932 Gene denotes ACE2 Gene:59272
2743 78966-78970 Gene denotes ACE2 Gene:59272
2744 79100-79104 Gene denotes ACE2 Gene:59272
2745 79492-79496 Gene denotes ACE2 Gene:59272
2746 80138-80142 Gene denotes ACE2 Gene:59272
2747 75617-75624 Gene denotes insulin Gene:3630
2748 75858-75861 Species denotes men Tax:9606
2749 75963-75967 Species denotes rats Tax:10116
2750 76286-76294 Species denotes patients Tax:9606
2751 76469-76477 Species denotes patients Tax:9606
2752 77553-77561 Species denotes patients Tax:9606
2753 77742-77750 Species denotes patients Tax:9606
2754 78034-78042 Species denotes patients Tax:9606
2755 78343-78351 Species denotes patients Tax:9606
2756 78400-78408 Species denotes patients Tax:9606
2757 78784-78794 Species denotes SARS-CoV-2 Tax:2697049
2758 79718-79726 Species denotes patients Tax:9606
2759 80320-80328 Species denotes patients Tax:9606
2760 81120-81133 Species denotes coronaviruses Tax:11118
2761 81224-81234 Species denotes SARS-CoV-2 Tax:2697049
2762 81307-81322 Species denotes influenza virus Tax:11308
2763 81385-81391 Species denotes humans Tax:9606
2764 81425-81438 Species denotes coronaviruses Tax:11118
2765 81631-81639 Species denotes SARS-CoV Tax:694009
2766 81644-81652 Species denotes MERS-CoV Tax:1335626
2767 82037-82047 Species denotes SARS-CoV-2 Tax:2697049
2768 77673-77678 Chemical denotes sACE2
2769 77686-77690 Chemical denotes Zn2+
2770 78215-78219 Chemical denotes Zn2+
2771 78463-78473 Chemical denotes olmesartan MESH:C437965
2772 75927-75939 Disease denotes hypertensive MESH:D006973
2773 76048-76054 Disease denotes asthma MESH:D001249
2774 76065-76082 Disease denotes allergic diseases MESH:D004342
2775 76114-76122 Disease denotes COVID-19 MESH:C000657245
2776 76300-76323 Disease denotes cardiovascular diseases MESH:D002318
2777 76329-76355 Disease denotes inflammatory bowel disease MESH:D015212
2778 76489-76497 Disease denotes COVID-19 MESH:C000657245
2779 76529-76548 Disease denotes atrial fibrillation MESH:D001281
2780 76624-76643 Disease denotes cardiac dysfunction MESH:D006331
2781 76677-76689 Disease denotes hypertension MESH:D006973
2782 76705-76721 Disease denotes vascular disease MESH:D000783
2783 76874-76882 Disease denotes COVID-19 MESH:C000657245
2784 77080-77095 Disease denotes viral infection MESH:D001102
2785 77302-77310 Disease denotes COVID-19 MESH:C000657245
2786 77401-77409 Disease denotes COVID-19 MESH:C000657245
2787 77506-77527 Disease denotes chronic renal disease MESH:D051436
2788 77531-77539 Disease denotes COVID-19 MESH:C000657245
2789 77719-77741 Disease denotes chronic kidney disease MESH:D051436
2790 77772-77794 Disease denotes cardiovascular disease MESH:D002318
2791 77933-77944 Disease denotes proteinuria MESH:D011507
2792 78011-78033 Disease denotes chronic kidney disease MESH:D051436
2793 78127-78149 Disease denotes chronic renal diseases MESH:D051436
2794 78357-78379 Disease denotes chronic renal diseases MESH:D051436
2795 78387-78399 Disease denotes hypertensive MESH:D006973
2796 78528-78541 Disease denotes hyperactivity MESH:D006948
2797 78657-78665 Disease denotes COVID-19 MESH:C000657245
2798 78763-78773 Disease denotes infections MESH:D007239
2799 78874-78894 Disease denotes SARS-CoV-2 infection MESH:C000657245
2800 79154-79166 Disease denotes hypertension MESH:D006973
2801 79168-79180 Disease denotes dyslipidemia MESH:D050171
2802 79189-79197 Disease denotes diabetes MESH:D003920
2803 79202-79228 Disease denotes cardiovascular dysfunction MESH:D002318
2804 79528-79536 Disease denotes COVID-19 MESH:C000657245
2805 79565-79588 Disease denotes obstructive sleep apnea MESH:D020181
2806 79646-79654 Disease denotes COVID-19 MESH:C000657245
2807 79709-79717 Disease denotes COVID-19 MESH:C000657245
2808 79819-79827 Disease denotes Covid-19 MESH:C000657245
2809 79885-79899 Disease denotes apnea/hypopnea MESH:D020181
2810 79917-79927 Disease denotes hypoxaemia
2811 79935-79940 Disease denotes sleep MESH:D012893
2812 79967-79979 Disease denotes hypertension MESH:D006973
2813 79981-80003 Disease denotes cardiovascular disease MESH:D002318
2814 80005-80013 Disease denotes diabetes MESH:D003920
2815 80015-80022 Disease denotes obesity MESH:D009765
2816 80036-80048 Disease denotes inflammation MESH:D007249
2817 80170-80177 Disease denotes hypoxia MESH:D000860
2818 80291-80311 Disease denotes SARS-CoV-2 infection MESH:C000657245
2819 80631-80636 Disease denotes sleep MESH:D012893
2820 80764-80772 Disease denotes COVID-19 MESH:C000657245
2821 81370-81381 Disease denotes common cold MESH:D003139
2822 81689-81709 Disease denotes SARS-CoV-2 infection MESH:C000657245
2823 82009-82025 Disease denotes virus infections MESH:D001102
2827 82320-82323 Gene denotes ACE Gene:59272
2828 82324-82328 Gene denotes ACE2 Gene:59272
2829 82341-82349 Disease denotes COVID-19 MESH:C000657245
2872 83407-83411 Gene denotes ACE2 Gene:59272
2873 83440-83444 Gene denotes ACE2 Gene:59272
2874 83674-83678 Gene denotes IL-4 Gene:3565
2875 83680-83684 Gene denotes IL-5 Gene:3567
2876 83689-83694 Gene denotes IL-10 Gene:3586
2877 83728-83731 Gene denotes Th2 Gene:15111
2878 83888-83893 Gene denotes IL-10 Gene:3586
2879 84178-84182 Gene denotes ACE2 Gene:59272
2880 84262-84266 Gene denotes ACE2 Gene:59272
2881 84291-84296 Gene denotes IL-10 Gene:3586
2882 84405-84410 Gene denotes renin Gene:5972
2883 84411-84414 Gene denotes ACE Gene:59272
2884 84522-84526 Gene denotes IL-6 Gene:3569
2885 83778-83781 Gene denotes CD4 Gene:920
2886 83643-83646 Gene denotes Th2 Gene:15111
2887 82582-82590 Species denotes patients Tax:9606
2888 82597-82607 Species denotes SARS-CoV-2 Tax:2697049
2889 82722-82730 Species denotes patients Tax:9606
2890 82994-83004 Species denotes SARS-CoV-2 Tax:2697049
2891 83076-83086 Species denotes SARS-CoV-2 Tax:2697049
2892 83143-83151 Species denotes SARS-CoV Tax:694009
2893 83249-83257 Species denotes SARS-CoV Tax:694009
2894 83997-84005 Species denotes patients Tax:9606
2895 84088-84098 Species denotes SARS-CoV-2 Tax:2697049
2896 84099-84107 Species denotes patients Tax:9606
2897 82476-82496 Disease denotes SARS-CoV-2 infection MESH:C000657245
2898 82573-82581 Disease denotes COVID-19 MESH:C000657245
2899 82713-82721 Disease denotes COVID-19 MESH:C000657245
2900 83181-83187 Disease denotes asthma MESH:D001249
2901 83461-83479 Disease denotes SARS-CoV infection MESH:C000657245
2902 83506-83512 Disease denotes asthma MESH:D001249
2903 83572-83590 Disease denotes SARS-CoV infection MESH:C000657245
2904 83830-83839 Disease denotes infection MESH:D007239
2905 83896-83908 Disease denotes eosinopaenia
2906 83910-83921 Disease denotes tachycardia MESH:D013610
2907 83929-83940 Disease denotes hypotension MESH:D007022
2908 83951-83959 Disease denotes COVID-19 MESH:C000657245
2909 83964-83987 Disease denotes hypoxia increase Ang II MESH:D000860
2910 84011-84023 Disease denotes hypertensive MESH:D006973
2911 84047-84059 Disease denotes hypertensive MESH:D006973
2912 84077-84084 Disease denotes hypoxia MESH:D000860
2913 84553-84561 Disease denotes COVID-19 MESH:C000657245
2916 84625-84629 Gene denotes ACE2 Gene:59272
2917 84856-84874 Disease denotes multi-organ injury MESH:D009102
2923 85440-85444 Gene denotes ACE2 Gene:59272
2924 85582-85586 Gene denotes ACE2 Gene:59272
2925 85388-85398 Species denotes SARS-CoV-2 Tax:2697049
2926 85800-85808 Species denotes patients Tax:9606
2927 85791-85799 Disease denotes COVID-19 MESH:C000657245
2934 85869-85872 Gene denotes ACE Gene:59272
2935 85873-85877 Gene denotes ACE2 Gene:59272
2936 86011-86015 Gene denotes ACE2 Gene:59272
2937 86097-86100 Gene denotes ACE Gene:59272
2938 86101-86105 Gene denotes ACE2 Gene:59272
2939 86066-86071 Chemical denotes ZnCl2 MESH:C016837
2942 86223-86226 Gene denotes ACE Gene:59272
2943 86227-86231 Gene denotes ACE2 Gene:59272
2947 86334-86338 Gene denotes AT1R Gene:185
2948 86340-86344 Gene denotes AT2R Gene:24182
2949 86349-86353 Gene denotes MasR Gene:116511
2952 86160-86163 Gene denotes ACE Gene:59272
2953 86164-86168 Gene denotes ACE2 Gene:59272
2965 84934-84937 Gene denotes ACE Gene:59272
2966 84938-84942 Gene denotes ACE2 Gene:59272
2967 84982-84985 Gene denotes ACE Gene:59272
2968 84990-84994 Gene denotes ACE2 Gene:59272
2969 85032-85039 Gene denotes Ang 1–9 Gene:284
2970 85063-85071 Gene denotes Ang (1–5 Gene:284
2971 85124-85134 Gene denotes bradykinin Gene:3827
2972 85085-85095 Gene denotes bradykinin Gene:3827
2973 85049-85057 Gene denotes Ang (1–7 Gene:27329
2974 85041-85047 Gene denotes Ang II Gene:24179
2975 85074-85081 Chemical denotes des-Arg
2984 86464-86468 Gene denotes ACE2 Gene:59272
2985 86587-86591 Gene denotes MasR Gene:116511
2986 86701-86711 Gene denotes bradykinin Gene:3827
2987 86851-86855 Gene denotes ACE2 Gene:59272
2988 86428-86436 Gene denotes Ang (1–7 Gene:284
2989 86731-86739 Species denotes patients Tax:9606
2990 86546-86552 Gene denotes Ang II Gene:24179
2991 86722-86730 Disease denotes COVID-19 MESH:C000657245
3005 86945-86950 Gene denotes rACE2 Gene:302668
3006 87064-87068 Gene denotes ACE2 Gene:59272
3007 87227-87235 Gene denotes Ang (1–9 Gene:284
3008 87238-87246 Gene denotes Ang (1–7 Gene:284
3009 87253-87256 Gene denotes ACE Gene:59272
3010 87295-87303 Gene denotes Ang (1–5 Gene:284
3011 87352-87355 Gene denotes ACE Gene:59272
3012 87356-87360 Gene denotes ACE2 Gene:59272
3013 87123-87129 Gene denotes Ang II Gene:24179
3014 87267-87275 Gene denotes Ang (1–5 Gene:284
3015 86939-86944 Species denotes human Tax:9606
3016 87391-87399 Species denotes patients Tax:9606
3017 87382-87390 Disease denotes COVID-19 MESH:C000657245
3033 87471-87477 Gene denotes Ang II Gene:24179
3034 87749-87757 Gene denotes Ang (1–7 Gene:284
3035 87760-87768 Gene denotes Ang (1–9 Gene:284
3036 87771-87779 Gene denotes Ang (1–5 Gene:284
3037 87785-87795 Gene denotes bradykinin Gene:3827
3038 87501-87509 Species denotes patients Tax:9606
3039 87918-87926 Species denotes patients Tax:9606
3040 87481-87500 Disease denotes SARS-CoV-2 infected MESH:C000657245
3041 87683-87694 Disease denotes lung injury MESH:D055370
3042 87877-87888 Disease denotes hypotension MESH:D007022
3043 87893-87905 Disease denotes eosinopaenia
3044 87909-87917 Disease denotes COVID-19 MESH:C000657245
3045 87978-88013 Disease denotes Acute Respiratory distress syndrome MESH:D012128
3046 88017-88025 Disease denotes COVID-19 MESH:C000657245
3047 88045-88076 Disease denotes pulmonary arterial hypertension MESH:D000081029
3049 88119-88154 Disease denotes Acute Respiratory distress syndrome MESH:D012128
3076 88510-88513 Gene denotes ACE Gene:59272
3077 88665-88669 Gene denotes ACE2 Gene:59272
3078 88717-88721 Gene denotes AT1R Gene:185
3079 88776-88780 Gene denotes ACE2 Gene:59272
3080 88865-88869 Gene denotes ACE2 Gene:59272
3081 88230-88238 Species denotes patients Tax:9606
3082 88474-88483 Species denotes SARS-CoVs Tax:694009
3083 88487-88492 Species denotes human Tax:9606
3084 88493-88508 Species denotes influenza virus Tax:11308
3085 88583-88589 Species denotes humans Tax:9606
3086 88859-88864 Species denotes human Tax:9606
3087 89106-89114 Species denotes patients Tax:9606
3088 88710-88716 Gene denotes Ang II Gene:24179
3089 88225-88229 Disease denotes ARDS MESH:D012128
3090 88312-88321 Disease denotes hypoxemia MESH:D000860
3091 88323-88327 Disease denotes ARDS MESH:D012128
3092 88389-88395 Disease denotes sepsis MESH:D018805
3093 88397-88403 Disease denotes trauma MESH:D014947
3094 88405-88423 Disease denotes acute pancreatitis MESH:D010195
3095 88428-88438 Disease denotes pneumonias MESH:D011014
3096 88449-88465 Disease denotes virus infections MESH:D001102
3097 88575-88579 Disease denotes ARDS MESH:D012128
3098 88636-88640 Disease denotes ARDS MESH:D012128
3099 88784-88788 Disease denotes ARDS MESH:D012128
3100 88978-88982 Disease denotes ARDS MESH:D012128
3101 89097-89105 Disease denotes COVID-19 MESH:C000657245
3215 89526-89531 Gene denotes renin Gene:5972
3216 90289-90294 Gene denotes renin Gene:5972
3217 90296-90299 Gene denotes ACE Gene:59272
3218 90307-90311 Gene denotes ACE2 Gene:59272
3219 90592-90600 Gene denotes Ang (1–9 Gene:284
3220 90896-90899 Gene denotes ACE Gene:59272
3221 90908-90912 Gene denotes ACE2 Gene:59272
3222 91222-91230 Gene denotes Ang (1–9 Gene:284
3223 91389-91392 Gene denotes ACE Gene:59272
3224 91428-91432 Gene denotes ACE2 Gene:59272
3225 91443-91447 Gene denotes MasR Gene:116511
3226 91865-91871 Gene denotes Ang II Gene:24179
3227 92274-92282 Gene denotes Ang (1–7 Gene:284
3228 92802-92806 Gene denotes ACE2 Gene:59272
3229 92821-92825 Gene denotes ACE2 Gene:59272
3230 92993-93001 Gene denotes Ang (1–9 Gene:284
3231 93055-93059 Gene denotes ACE2 Gene:59272
3232 93085-93088 Gene denotes ACE Gene:59272
3233 93276-93281 Gene denotes rACE2 Gene:302668
3234 93436-93439 Gene denotes ACE Gene:59272
3235 93493-93497 Gene denotes ACE2 Gene:59272
3236 93527-93535 Gene denotes Ang (1–9 Gene:284
3237 93579-93583 Gene denotes ACE2 Gene:59272
3238 93607-93615 Gene denotes Ang (1–9 Gene:284
3239 93649-93657 Gene denotes Ang (1–5 Gene:284
3240 93692-93696 Gene denotes ACE2 Gene:59272
3241 93739-93742 Gene denotes ACE Gene:59272
3242 93776-93784 Gene denotes Ang (1–5 Gene:284
3243 93988-93992 Gene denotes ACE2 Gene:59272
3244 93997-94000 Gene denotes ACE Gene:59272
3245 94288-94293 Gene denotes renin Gene:5972
3246 94365-94373 Gene denotes Ang (1–9 Gene:284
3247 94418-94422 Gene denotes ACE2 Gene:59272
3248 94454-94462 Gene denotes Ang (1–9 Gene:284
3249 94576-94581 Gene denotes rACE2 Gene:302668
3250 94633-94641 Gene denotes Ang (1–9 Gene:284
3251 94655-94663 Gene denotes Ang (1–5 Gene:284
3252 94811-94815 Gene denotes ACE2 Gene:59272
3253 95109-95113 Gene denotes ACE2 Gene:59272
3254 95364-95369 Gene denotes TNF-α Gene:7124
3255 95496-95504 Gene denotes Ang (1–7 Gene:284
3256 95561-95566 Gene denotes hACE2 Gene:59272
3257 95273-95281 Gene denotes Ang (1–7 Gene:284
3258 94669-94677 Gene denotes Ang (1–7 Gene:284
3259 94346-94354 Gene denotes Ang (1–5 Gene:284
3260 94332-94340 Gene denotes Ang (1–7 Gene:284
3261 93803-93811 Gene denotes Ang (1–5 Gene:284
3262 93791-93799 Gene denotes Ang (1–7 Gene:284
3263 93341-93349 Gene denotes Ang (1–9 Gene:284
3264 92703-92711 Gene denotes Ang (1–7 Gene:284
3265 92629-92637 Gene denotes Ang (1–7 Gene:284
3266 92414-92422 Gene denotes Ang (1–7 Gene:284
3267 92130-92138 Gene denotes Ang (1–7 Gene:284
3268 92116-92124 Gene denotes Ang (1–7 Gene:284
3269 91433-91441 Gene denotes Ang (1–7 Gene:284
3270 91236-91244 Gene denotes Ang (1–7 Gene:284
3271 91204-91212 Gene denotes Ang (1–7 Gene:284
3272 91151-91159 Gene denotes Ang (1–7 Gene:284
3273 91043-91051 Gene denotes Ang (1–7 Gene:284
3274 90606-90614 Gene denotes Ang (1–5 Gene:284
3275 90581-90589 Gene denotes Ang (1–7 Gene:284
3276 94146-94151 Gene denotes renin Gene:5972
3277 90886-90891 Gene denotes renin Gene:5972
3278 89301-89309 Species denotes patients Tax:9606
3279 89563-89571 Species denotes patients Tax:9606
3280 89707-89714 Species denotes patient Tax:9606
3281 91314-91322 Species denotes patients Tax:9606
3282 91528-91536 Species denotes patients Tax:9606
3283 92168-92176 Species denotes patients Tax:9606
3284 92890-92898 Species denotes patients Tax:9606
3285 93270-93275 Species denotes human Tax:9606
3286 93304-93312 Species denotes patients Tax:9606
3287 93506-93514 Species denotes patients Tax:9606
3288 93909-93917 Species denotes patients Tax:9606
3289 94514-94522 Species denotes patients Tax:9606
3290 94570-94575 Species denotes human Tax:9606
3291 94719-94727 Species denotes patients Tax:9606
3292 94874-94882 Species denotes patients Tax:9606
3293 95324-95332 Species denotes patients Tax:9606
3294 95574-95582 Species denotes patients Tax:9606
3295 93712-93720 Gene denotes Ang (1–7 Gene:27329
3296 95489-95495 Gene denotes Ang II Gene:24179
3297 95262-95268 Gene denotes Ang II Gene:24179
3298 94324-94330 Gene denotes Ang II Gene:24179
3299 93758-93764 Gene denotes Ang II Gene:24179
3300 93727-93733 Gene denotes Ang II Gene:24179
3301 92713-92719 Gene denotes Ang II Gene:24179
3302 92518-92524 Gene denotes Ang II Gene:24179
3303 92424-92430 Gene denotes Ang II Gene:24179
3304 92360-92366 Gene denotes Ang II Gene:24179
3305 92140-92146 Gene denotes Ang II Gene:24179
3306 91702-91708 Gene denotes Ang II Gene:24179
3307 91246-91252 Gene denotes Ang II Gene:24179
3308 91161-91167 Gene denotes Ang II Gene:24179
3309 91032-91038 Gene denotes Ang II Gene:24179
3310 90573-90579 Gene denotes Ang II Gene:24179
3311 90348-90359 Chemical denotes Ang peptide
3312 89296-89300 Disease denotes ARDS MESH:D012128
3313 89558-89562 Disease denotes ARDS MESH:D012128
3314 89614-89618 Disease denotes ARDS MESH:D012128
3315 91301-91313 Disease denotes hypertensive MESH:D006973
3316 91523-91527 Disease denotes ARDS MESH:D012128
3317 92163-92167 Disease denotes ARDS MESH:D012128
3318 92885-92889 Disease denotes ARDS MESH:D012128
3319 93299-93303 Disease denotes ARDS MESH:D012128
3320 93501-93505 Disease denotes ARDS MESH:D012128
3321 93904-93908 Disease denotes ARDS MESH:D012128
3322 94509-94513 Disease denotes ARDS MESH:D012128
3323 94714-94718 Disease denotes ARDS MESH:D012128
3324 94869-94873 Disease denotes ARDS MESH:D012128
3325 95190-95214 Disease denotes coronary atherosclerosis MESH:D003324
3326 95414-95437 Disease denotes coronary artery disease MESH:D003324
3327 95613-95622 Disease denotes pressures MESH:D006973
3329 95925-95933 Disease denotes COVID-19 MESH:C000657245
3347 95989-95993 Gene denotes ACE2 Gene:59272
3348 96107-96111 Gene denotes ACE2 Gene:59272
3349 96260-96264 Gene denotes ACE2 Gene:59272
3350 96331-96335 Gene denotes ACE2 Gene:59272
3351 96365-96369 Gene denotes ACE2 Gene:59272
3352 96390-96393 Gene denotes ACE Gene:59272
3353 96394-96398 Gene denotes ACE2 Gene:59272
3354 96547-96551 Gene denotes ACE2 Gene:59272
3355 96578-96582 Gene denotes MasR Gene:116511
3356 96602-96607 Gene denotes renin Gene:5972
3357 96346-96350 Gene denotes MasR Gene:116511
3358 96035-96043 Species denotes patients Tax:9606
3359 96217-96227 Species denotes SARS-CoV-2 Tax:2697049
3360 96336-96344 Gene denotes Ang (1–7 Gene:27329
3361 96626-96631 Chemical denotes metal MESH:D008670
3362 96026-96034 Disease denotes COVID-19 MESH:C000657245
3363 96473-96480 Disease denotes hypoxia MESH:D000860
3387 96720-96724 Gene denotes ACE2 Gene:59272
3388 96854-96858 Gene denotes ACE2 Gene:70008
3389 96951-96955 Gene denotes ACE2 Gene:70008
3390 97148-97152 Gene denotes ACE2 Gene:59272
3391 97367-97371 Gene denotes ACE2 Gene:59272
3392 97331-97334 Gene denotes MLN Gene:4295
3393 97175-97178 Gene denotes MLN Gene:4295
3394 96781-96785 Gene denotes MasR Gene:116511
3395 96714-96719 Species denotes human Tax:9606
3396 96775-96780 Species denotes human Tax:9606
3397 96903-96908 Species denotes mouse Tax:10090
3398 96909-96912 Species denotes rat Tax:10116
3399 96935-96940 Species denotes human Tax:9606
3400 96945-96950 Species denotes mouse Tax:10090
3401 96971-96976 Species denotes mouse Tax:10090
3402 97006-97011 Species denotes mouse Tax:10090
3403 97012-97015 Species denotes rat Tax:10116
3404 97066-97071 Species denotes human Tax:9606
3405 97072-97084 Species denotes participants Tax:9606
3406 97142-97147 Species denotes human Tax:9606
3407 97419-97425 Species denotes humans Tax:9606
3408 96987-96994 Disease denotes colitis MESH:D003092
3409 97115-97123 Disease denotes toxicity MESH:D064420
3416 97597-97601 Gene denotes ACE2 Gene:59272
3417 97709-97713 Gene denotes ACE2 Gene:59272
3418 97591-97596 Species denotes human Tax:9606
3419 97696-97701 Species denotes human Tax:9606
3420 97899-97907 Species denotes patients Tax:9606
3421 97887-97895 Disease denotes COVID-19 MESH:C000657245
3424 98052-98056 Gene denotes ACE2 Gene:59272
3425 98058-98061 Gene denotes MLN Gene:4295
3437 98339-98343 Gene denotes ACE2 Gene:59272
3438 98485-98489 Gene denotes ACE2 Gene:59272
3439 98575-98579 Gene denotes ACE2 Gene:59272
3440 98657-98661 Gene denotes ACE2 Gene:59272
3441 98682-98686 Gene denotes ACE2 Gene:59272
3442 98589-98594 Gene denotes spike Gene:43740568
3443 98464-98472 Species denotes patients Tax:9606
3444 98479-98484 Species denotes human Tax:9606
3445 98698-98708 Species denotes SARS-CoV-2 Tax:2697049
3446 98412-98423 Disease denotes hypercapnia MESH:D006935
3447 98455-98463 Disease denotes COVID-19 MESH:C000657245
3451 98859-98863 Gene denotes ACE2 Gene:59272
3452 98963-98967 Gene denotes ACE2 Gene:59272
3453 99067-99073 Species denotes humans Tax:9606
3457 99321-99325 Gene denotes ACE2 Gene:59272
3458 99530-99537 Gene denotes insulin Gene:3630
3459 99431-99436 Chemical denotes water MESH:D014867
3466 99691-99695 Gene denotes ACE2 Gene:59272
3467 99654-99667 Chemical denotes disodium salt
3468 99855-99885 Chemical denotes 2-hydroxypropyl-β-cyclodextrin MESH:D000073738
3469 99887-99892 Chemical denotes HPBDC
3470 99898-99901 Chemical denotes H2O
3471 99930-99936 Chemical denotes GL1001 MESH:C486469
3477 100249-100253 Gene denotes ACE2 Gene:59272
3478 100025-100028 Gene denotes MLN Gene:4295
3479 100003-100009 Species denotes humans Tax:9606
3480 100155-100181 Disease denotes Inflammatory bowel disease MESH:D015212
3481 100183-100204 Disease denotes gastritis and colitis MESH:D005756
3490 101203-101207 Gene denotes ACE2 Gene:59272
3491 101428-101431 Gene denotes MLN Gene:4295
3492 100975-100978 Gene denotes MLN Gene:69563
3493 101076-101080 Species denotes mice Tax:10090
3494 101084-101095 Species denotes Pseudomonas Tax:287
3495 101062-101075 Disease denotes lung-infected MESH:D012141
3496 101223-101240 Disease denotes lung inflammation MESH:D011014
3497 101415-101423 Disease denotes toxicity MESH:D064420
3499 99219-99225 Species denotes humans Tax:9606
3504 98214-98218 Gene denotes ACE2 Gene:59272
3505 98195-98198 Gene denotes MLN Gene:4295
3506 98121-98129 Species denotes patients Tax:9606
3507 98112-98120 Disease denotes COVID-19 MESH:C000657245
3528 101909-101912 Gene denotes ACE Gene:59272
3529 101913-101917 Gene denotes ACE2 Gene:59272
3530 101937-101940 Gene denotes ACE Gene:59272
3531 101999-102003 Gene denotes ACE2 Gene:59272
3532 102683-102687 Gene denotes ACE2 Gene:59272
3533 102848-102852 Gene denotes ACE2 Gene:59272
3534 103093-103097 Gene denotes ACE2 Gene:59272
3535 102491-102494 Gene denotes MLN Gene:4295
3536 102179-102182 Gene denotes MLN Gene:4295
3537 101508-101511 Gene denotes MLN Gene:4295
3538 101692-101700 Species denotes patients Tax:9606
3539 102117-102125 Species denotes patients Tax:9606
3540 102654-102662 Species denotes patients Tax:9606
3541 102913-102921 Species denotes patients Tax:9606
3542 103025-103030 Species denotes human Tax:9606
3543 103134-103142 Species denotes patients Tax:9606
3544 103301-103308 Species denotes patient Tax:9606
3545 101788-101806 Disease denotes hypoxic conditions MESH:D000071069
3546 102108-102116 Disease denotes COVID-19 MESH:C000657245
3547 102904-102912 Disease denotes COVID-19 MESH:C000657245
3549 103340-103345 Gene denotes Renin Gene:5972
3574 103484-103489 Gene denotes renin Gene:5972
3575 104036-104039 Gene denotes ACE Gene:59272
3576 104044-104048 Gene denotes ACE2 Gene:59272
3577 104156-104160 Gene denotes AT1R Gene:24180
3578 104287-104292 Gene denotes renin Gene:24715
3579 104432-104436 Gene denotes AT2R Gene:24182
3580 104441-104445 Gene denotes ACE2 Gene:59272
3581 104165-104169 Gene denotes MasR Gene:116511
3582 104254-104262 Gene denotes Ang (1–7 Gene:305843
3583 103448-103453 Gene denotes renin Gene:5972
3584 103836-103844 Species denotes patients Tax:9606
3585 104117-104121 Species denotes rats Tax:10116
3586 104243-104249 Gene denotes Ang II Gene:24179
3587 103688-103697 Chemical denotes Aliskiren MESH:C446481
3588 104094-104103 Chemical denotes Aliskiren MESH:C446481
3589 104575-104584 Chemical denotes CaNa2EDTA
3590 104588-104601 Chemical denotes nicotianamine MESH:C082893
3591 103668-103680 Disease denotes hypertension MESH:D006973
3592 103759-103767 Disease denotes COVID-19 MESH:C000657245
3593 103803-103823 Disease denotes SARS-CoV-2 infection MESH:C000657245
3594 103869-103877 Disease denotes COVID-19 MESH:C000657245
3595 103878-103885 Disease denotes hypoxia MESH:D000860
3596 104049-104062 Disease denotes hyperactivity MESH:D006948
3597 104352-104372 Disease denotes SARS-CoV-2 infection MESH:C000657245
3599 104673-104682 Chemical denotes CaNa2EDTA
3623 104829-104833 Gene denotes ACE2 Gene:59272
3624 104838-104841 Gene denotes ACE Gene:59272
3625 104869-104873 Gene denotes ACE2 Gene:59272
3626 104879-104882 Gene denotes ACE Gene:59272
3627 106251-106254 Gene denotes ACE Gene:59272
3628 106259-106263 Gene denotes ACE2 Gene:59272
3629 105162-105167 Gene denotes renin Gene:5972
3630 105652-105660 Gene denotes Ang-(1–7 Gene:284
3631 105718-105726 Species denotes patients Tax:9606
3632 106232-106240 Species denotes patients Tax:9606
3633 105992-106001 Chemical denotes CaNa2EDTA
3634 104779-104792 Disease denotes hyperactivity MESH:D006948
3635 105028-105048 Disease denotes SARS-CoV-2 infection MESH:C000657245
3636 105091-105098 Disease denotes hypoxia MESH:D000860
3637 105327-105335 Disease denotes COVID-19 MESH:C000657245
3638 105402-105422 Disease denotes SARS-CoV-2 infection MESH:C000657245
3639 105545-105549 Disease denotes ARDS MESH:D012128
3640 105599-105606 Disease denotes hypoxia MESH:D000860
3641 105611-105626 Disease denotes cardiac failure MESH:D006333
3642 105741-105745 Disease denotes ARDS MESH:D012128
3643 105777-105800 Disease denotes coronary artery disease MESH:D003324
3644 105911-105923 Disease denotes dysfunctions MESH:D009461
3645 106005-106027 Disease denotes coronary heart disease MESH:D003324
3669 107230-107233 Species denotes men Tax:9606
3670 107811-107819 Species denotes patients Tax:9606
3671 109065-109072 Species denotes patient Tax:9606
3672 106686-106693 Chemical denotes calcium MESH:D002118
3673 106702-106711 Chemical denotes CaNa2EDTA
3674 106824-106833 Chemical denotes CaNa2EDTA
3675 107039-107048 Chemical denotes CaNa2EDTA
3676 107304-107313 Chemical denotes CaNa2EDTA
3677 107346-107355 Chemical denotes CaNa2EDTA
3678 107567-107576 Chemical denotes CaNa2EDTA
3679 107671-107680 Chemical denotes CaNa2EDTA
3680 107893-107902 Chemical denotes CaNa2EDTA
3681 108097-108106 Chemical denotes CaNa2EDTA
3682 108179-108184 Chemical denotes metal MESH:D008670
3683 108299-108303 Chemical denotes EDTA MESH:D004492
3684 108589-108598 Chemical denotes CaNa2EDTA
3685 108869-108878 Chemical denotes CaNa2EDTA
3686 106770-106779 Disease denotes poisoning MESH:D011041
3687 107702-107711 Disease denotes poisoning MESH:D011041
3688 108070-108077 Disease denotes painful MESH:D010146
3689 108911-108919 Disease denotes COVID-19 MESH:C000657245
3690 109026-109034 Disease denotes COVID-19 MESH:C000657245
3691 109144-109152 Disease denotes toxicity MESH:D064420
3701 109411-109415 Gene denotes AT1R Gene:185
3702 109424-109428 Gene denotes AT2R Gene:24182
3703 109419-109423 Gene denotes MasR Gene:116511
3704 109556-109564 Species denotes patients Tax:9606
3705 109286-109297 Disease denotes dysfunction MESH:D009461
3706 109317-109336 Disease denotes cardiac dysfunction MESH:D006331
3707 109354-109364 Disease denotes thrombosis MESH:D013927
3708 109519-109530 Disease denotes dysfunction MESH:D009461
3709 109566-109574 Disease denotes COVID-19 MESH:C000657245
3733 110191-110198 Gene denotes albumin Gene:213
3734 110200-110205 Gene denotes IL-10 Gene:3586
3735 110207-110215 Gene denotes Ang (1–9 Gene:284
3736 110229-110237 Gene denotes Ang (1–5 Gene:284
3737 110246-110256 Gene denotes bradykinin Gene:3827
3738 110315-110318 Gene denotes ACE Gene:59272
3739 110326-110330 Gene denotes ACE2 Gene:59272
3740 110410-110413 Gene denotes ACE Gene:59272
3741 110418-110422 Gene denotes ACE2 Gene:59272
3742 111157-111161 Gene denotes ACE2 Gene:59272
3743 110218-110226 Gene denotes Ang (1–7 Gene:284
3744 110169-110176 Gene denotes albumin Gene:213
3745 110503-110511 Species denotes patients Tax:9606
3746 110654-110662 Species denotes patients Tax:9606
3747 110862-110869 Species denotes patient Tax:9606
3748 110149-110153 Chemical denotes Zn2+
3749 109911-109923 Disease denotes dysfunctions MESH:D009461
3750 110060-110068 Disease denotes COVID-19 MESH:C000657245
3751 110494-110502 Disease denotes COVID-19 MESH:C000657245
3752 110528-110556 Disease denotes eosinopaenia and hypotension MESH:D007022
3753 111024-111036 Disease denotes inflammation MESH:D007249
3754 111237-111257 Disease denotes SARS-CoV-2 infection MESH:C000657245
3755 111330-111338 Disease denotes COVID-19 MESH:C000657245
3762 111803-111807 Gene denotes ACE2 Gene:59272
3763 111872-111876 Gene denotes ACE2 Gene:59272
3764 112004-112012 Species denotes patients Tax:9606
3765 111561-111569 Disease denotes COVID-19 MESH:C000657245
3766 111642-111650 Disease denotes COVID-19 MESH:C000657245
3767 112299-112306 Disease denotes failure MESH:D006333
4705 113997-114000 Gene denotes ACE Gene:59272
4706 114001-114005 Gene denotes ACE2 Gene:59272
4707 114082-114092 Species denotes SARS-CoV-2 Tax:2697049
4708 113864-113869 Gene denotes renin Gene:5972
4709 114074-114081 Disease denotes hypoxia MESH:D000860
4712 114304-114308 Gene denotes ACE2 Gene:59272
4713 114160-114170 Species denotes SARS-CoV-2 Tax:2697049

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T1 107-115 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T2 277-285 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T3 277-281 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T4 585-593 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T5 776-784 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T6 776-780 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T7 1011-1058 Disease denotes severe acute respiratory syndrome coronavirus 2 http://purl.obolibrary.org/obo/MONDO_0100096
T8 1011-1044 Disease denotes severe acute respiratory syndrome http://purl.obolibrary.org/obo/MONDO_0005091
T9 1060-1068 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T10 1060-1064 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T11 1072-1081 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T12 1102-1110 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T13 1240-1248 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T14 1249-1258 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T15 1426-1434 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T16 1426-1430 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T17 1437-1446 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T18 1542-1575 Disease denotes severe acute respiratory syndrome http://purl.obolibrary.org/obo/MONDO_0005091
T19 1577-1581 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T20 1915-1919 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T21 1968-1974 Disease denotes injury http://purl.obolibrary.org/obo/MONDO_0021178
T22 2006-2018 Disease denotes coagulopathy http://purl.obolibrary.org/obo/MONDO_0001531
T23 2038-2046 Disease denotes acidosis http://purl.obolibrary.org/obo/MONDO_0006022
T24 2163-2175 Disease denotes hypertension http://purl.obolibrary.org/obo/MONDO_0005044
T25 2334-2340 Disease denotes asthma http://purl.obolibrary.org/obo/MONDO_0004979
T26 2443-2451 Disease denotes allergic http://purl.obolibrary.org/obo/MONDO_0004980
T27 2555-2561 Disease denotes asthma http://purl.obolibrary.org/obo/MONDO_0004979
T28 2623-2639 Disease denotes Viral infections http://purl.obolibrary.org/obo/MONDO_0005108
T29 2669-2685 Disease denotes allergic disease http://purl.obolibrary.org/obo/MONDO_0005271
T30 2669-2677 Disease denotes allergic http://purl.obolibrary.org/obo/MONDO_0004980
T31 2969-2973 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T32 2996-3016 Disease denotes hypertensive disease http://purl.obolibrary.org/obo/MONDO_0005044
T33 3107-3122 Disease denotes virus infection http://purl.obolibrary.org/obo/MONDO_0005108
T34 3113-3122 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T35 3167-3179 Disease denotes hypertension http://purl.obolibrary.org/obo/MONDO_0005044
T36 3336-3353 Disease denotes allergic diseases http://purl.obolibrary.org/obo/MONDO_0005271
T37 3336-3344 Disease denotes allergic http://purl.obolibrary.org/obo/MONDO_0004980
T38 3427-3431 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T39 3584-3592 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T40 3630-3651 Disease denotes chronic renal disease http://purl.obolibrary.org/obo/MONDO_0005300
T41 3638-3651 Disease denotes renal disease http://purl.obolibrary.org/obo/MONDO_0002118|http://purl.obolibrary.org/obo/MONDO_0005240
T43 3787-3809 Disease denotes chronic kidney disease http://purl.obolibrary.org/obo/MONDO_0005300
T44 3795-3809 Disease denotes kidney disease http://purl.obolibrary.org/obo/MONDO_0001343|http://purl.obolibrary.org/obo/MONDO_0005240
T46 3843-3851 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T47 3859-3865 Disease denotes asthma http://purl.obolibrary.org/obo/MONDO_0004979
T48 3894-3902 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T49 3894-3898 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T50 3907-3915 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T51 3907-3911 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T52 4026-4034 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T53 4026-4030 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T54 4243-4260 Disease denotes acute lung injury http://purl.obolibrary.org/obo/MONDO_0006502|http://purl.obolibrary.org/obo/MONDO_0015796
T56 4254-4260 Disease denotes injury http://purl.obolibrary.org/obo/MONDO_0021178
T57 4272-4280 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T58 4272-4276 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T59 4530-4539 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T60 5135-5143 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T61 5500-5508 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T62 5500-5504 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T63 5742-5757 Disease denotes viral infection http://purl.obolibrary.org/obo/MONDO_0005108
T64 5748-5757 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T65 5927-5938 Disease denotes common cold http://purl.obolibrary.org/obo/MONDO_0005709
T66 5977-5981 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T67 6057-6075 Disease denotes SARS-CoV infection http://purl.obolibrary.org/obo/MONDO_0005091
T68 6057-6061 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T69 6066-6075 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T70 6205-6220 Disease denotes viral infection http://purl.obolibrary.org/obo/MONDO_0005108
T71 6211-6220 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T72 6381-6392 Disease denotes hypotension http://purl.obolibrary.org/obo/MONDO_0005468
T73 6499-6507 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T74 6499-6503 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T75 7046-7054 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T76 7046-7050 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T77 7091-7100 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T78 7221-7230 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T79 7515-7523 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T80 7515-7519 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T81 7621-7629 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T82 7621-7625 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T83 7687-7695 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T84 7687-7691 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T85 7719-7725 Disease denotes injury http://purl.obolibrary.org/obo/MONDO_0021178
T86 7779-7787 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T87 7779-7783 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T88 8076-8080 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T89 8263-8267 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T90 9103-9112 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T91 9148-9156 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T92 9148-9152 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T93 9173-9182 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T94 9278-9286 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T95 9278-9282 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T96 10555-10559 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T97 10883-10892 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T98 10987-10995 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T99 11365-11373 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T100 11365-11369 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T101 11433-11441 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T102 11433-11437 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T103 11537-11545 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T104 11537-11541 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T105 11855-11863 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T106 11855-11859 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T107 12068-12076 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T108 12068-12072 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T109 12221-12229 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T110 12307-12315 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T111 12390-12398 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T112 12390-12394 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T113 12643-12659 Disease denotes Kawasaki disease http://purl.obolibrary.org/obo/MONDO_0012727
T114 12974-12982 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T115 12974-12978 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T116 13139-13147 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T117 13139-13143 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T118 13508-13517 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T119 13663-13671 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T120 13743-13751 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T121 14296-14307 Disease denotes hypotension http://purl.obolibrary.org/obo/MONDO_0005468
T122 14811-14823 Disease denotes inflammation http://purl.obolibrary.org/obo/MONDO_0021166
T123 14855-14865 Disease denotes thrombosis http://purl.obolibrary.org/obo/MONDO_0000831
T124 15372-15384 Disease denotes inflammation http://purl.obolibrary.org/obo/MONDO_0021166
T125 15453-15462 Disease denotes cirrhosis http://purl.obolibrary.org/obo/MONDO_0005155
T126 15472-15478 Disease denotes injury http://purl.obolibrary.org/obo/MONDO_0021178
T127 15842-15869 Disease denotes increases in blood pressure http://purl.obolibrary.org/obo/MONDO_0005044
T128 16213-16223 Disease denotes arrhythmia http://purl.obolibrary.org/obo/MONDO_0007263
T129 16238-16261 Disease denotes ventricular tachycardia http://purl.obolibrary.org/obo/MONDO_0005477
T130 16275-16299 Disease denotes ventricular fibrillation http://purl.obolibrary.org/obo/MONDO_0000190
T131 16568-16589 Disease denotes myocardial infarction http://purl.obolibrary.org/obo/MONDO_0005068
T132 16895-16916 Disease denotes myocardial infarction http://purl.obolibrary.org/obo/MONDO_0005068
T133 16950-16972 Disease denotes cardiovascular disease http://purl.obolibrary.org/obo/MONDO_0004995
T134 17056-17066 Disease denotes thrombosis http://purl.obolibrary.org/obo/MONDO_0000831
T135 17142-17152 Disease denotes thrombosis http://purl.obolibrary.org/obo/MONDO_0000831
T136 17166-17174 Disease denotes thrombus http://purl.obolibrary.org/obo/MONDO_0000831
T137 17315-17325 Disease denotes thrombosis http://purl.obolibrary.org/obo/MONDO_0000831
T138 17573-17583 Disease denotes thrombosis http://purl.obolibrary.org/obo/MONDO_0000831
T139 17740-17750 Disease denotes thrombosis http://purl.obolibrary.org/obo/MONDO_0000831
T140 17765-17803 Disease denotes disseminated intravascular coagulation http://purl.obolibrary.org/obo/MONDO_0001243
T141 17953-17964 Disease denotes proteinuria http://purl.obolibrary.org/obo/MONDO_0003634
T142 18178-18189 Disease denotes hepatitis C http://purl.obolibrary.org/obo/MONDO_0005231
T143 18178-18187 Disease denotes hepatitis http://purl.obolibrary.org/obo/MONDO_0002251
T144 18190-18199 Disease denotes cirrhosis http://purl.obolibrary.org/obo/MONDO_0005155
T145 19091-19104 Disease denotes heart disease http://purl.obolibrary.org/obo/MONDO_0005267
T146 19481-19484 Disease denotes AT1 http://purl.obolibrary.org/obo/MONDO_0008840
T147 19511-19533 Disease denotes pulmonary hypertensive http://purl.obolibrary.org/obo/MONDO_0005149
T148 20109-20117 Disease denotes acidosis http://purl.obolibrary.org/obo/MONDO_0006022
T149 20163-20167 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T150 20708-20712 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T151 21311-21337 Disease denotes inflammatory bowel disease http://purl.obolibrary.org/obo/MONDO_0005265
T152 21819-21831 Disease denotes inflammation http://purl.obolibrary.org/obo/MONDO_0021166
T153 21835-21853 Disease denotes pulmonary fibrosis http://purl.obolibrary.org/obo/MONDO_0002771
T154 22190-22198 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T155 22236-22244 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T156 22236-22240 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T157 22352-22356 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T158 22374-22389 Disease denotes viral infection http://purl.obolibrary.org/obo/MONDO_0005108
T159 22380-22389 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T160 23299-23307 Disease denotes allergic http://purl.obolibrary.org/obo/MONDO_0004980
T161 23315-23327 Disease denotes inflammation http://purl.obolibrary.org/obo/MONDO_0021166
T162 23388-23394 Disease denotes asthma http://purl.obolibrary.org/obo/MONDO_0004979
T163 23458-23464 Disease denotes asthma http://purl.obolibrary.org/obo/MONDO_0004979
T164 23510-23516 Disease denotes asthma http://purl.obolibrary.org/obo/MONDO_0004979
T165 24210-24218 Disease denotes allergic http://purl.obolibrary.org/obo/MONDO_0004980
T166 24219-24231 Disease denotes inflammation http://purl.obolibrary.org/obo/MONDO_0021166
T167 24569-24577 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T168 24734-24742 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T169 26703-26706 Disease denotes AT1 http://purl.obolibrary.org/obo/MONDO_0008840
T170 26846-26849 Disease denotes AT1 http://purl.obolibrary.org/obo/MONDO_0008840
T171 26942-26950 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T172 26942-26946 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T173 26953-26962 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T174 27210-27218 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T175 27210-27214 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T176 27570-27578 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T177 27570-27574 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T178 27633-27641 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T179 27756-27764 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T180 27756-27760 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T181 27868-27876 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T182 27868-27872 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T183 27997-28005 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T184 27997-28001 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T185 28161-28165 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T186 28277-28285 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T187 28277-28281 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T188 28535-28543 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T189 28535-28539 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T190 28557-28565 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T191 28557-28561 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T192 28735-28743 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T193 28735-28739 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T194 29317-29325 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T195 29317-29321 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T196 29354-29363 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T197 29411-29429 Disease denotes SARS-CoV infection http://purl.obolibrary.org/obo/MONDO_0005091
T198 29411-29415 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T199 29420-29429 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T200 29713-29721 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T201 29713-29717 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T202 29970-29978 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T203 29970-29974 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T204 30160-30175 Disease denotes viral infection http://purl.obolibrary.org/obo/MONDO_0005108
T205 30166-30175 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T206 30645-30653 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T207 30645-30649 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T208 30740-30751 Disease denotes Hypotension http://purl.obolibrary.org/obo/MONDO_0005468
T209 31126-31141 Disease denotes virus infection http://purl.obolibrary.org/obo/MONDO_0005108
T210 31132-31141 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T211 31188-31198 Disease denotes infections http://purl.obolibrary.org/obo/MONDO_0005550
T212 31342-31350 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T213 31342-31346 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T214 31353-31362 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T215 32016-32026 Disease denotes thrombosis http://purl.obolibrary.org/obo/MONDO_0000831
T216 32135-32143 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T217 32135-32139 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T218 32575-32586 Disease denotes hypotension http://purl.obolibrary.org/obo/MONDO_0005468
T219 32602-32610 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T220 32602-32606 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T221 32870-32886 Disease denotes systemic disease http://purl.obolibrary.org/obo/MONDO_0015938
T222 32944-32952 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T223 32944-32948 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T224 33138-33146 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T225 34195-34203 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T226 34195-34199 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T227 34779-34787 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T228 34908-34926 Disease denotes immune suppression http://purl.obolibrary.org/obo/MONDO_0007816
T229 35478-35482 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T230 37081-37087 Disease denotes injury http://purl.obolibrary.org/obo/MONDO_0021178
T231 37466-37476 Disease denotes arrhythmia http://purl.obolibrary.org/obo/MONDO_0007263
T232 37989-37997 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T233 39344-39355 Disease denotes hypotension http://purl.obolibrary.org/obo/MONDO_0005468
T234 40055-40063 Disease denotes COVID–19 http://purl.obolibrary.org/obo/MONDO_0100096
T235 40257-40265 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T236 40543-40551 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T237 40543-40547 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T238 40572-40607 Disease denotes adult respiratory distress syndrome http://purl.obolibrary.org/obo/MONDO_0006502
T239 40578-40607 Disease denotes respiratory distress syndrome http://purl.obolibrary.org/obo/MONDO_0009971
T240 40609-40613 Disease denotes ARDS http://purl.obolibrary.org/obo/MONDO_0006502
T241 40617-40625 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T242 40687-40713 Disease denotes inflammatory bowel disease http://purl.obolibrary.org/obo/MONDO_0005265
T243 40715-40718 Disease denotes IBD http://purl.obolibrary.org/obo/MONDO_0005052|http://purl.obolibrary.org/obo/MONDO_0005265
T245 41197-41201 Disease denotes ARDS http://purl.obolibrary.org/obo/MONDO_0006502
T246 41379-41383 Disease denotes ARDS http://purl.obolibrary.org/obo/MONDO_0006502
T247 42511-42515 Disease denotes ARDS http://purl.obolibrary.org/obo/MONDO_0006502
T248 42607-42611 Disease denotes ARDS http://purl.obolibrary.org/obo/MONDO_0006502
T249 42657-42665 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T250 42905-42921 Disease denotes allergic disease http://purl.obolibrary.org/obo/MONDO_0005271
T251 42905-42913 Disease denotes allergic http://purl.obolibrary.org/obo/MONDO_0004980
T252 42935-42957 Disease denotes chronic kidney disease http://purl.obolibrary.org/obo/MONDO_0005300
T253 42943-42957 Disease denotes kidney disease http://purl.obolibrary.org/obo/MONDO_0001343|http://purl.obolibrary.org/obo/MONDO_0005240
T255 42988-43010 Disease denotes cardiovascular disease http://purl.obolibrary.org/obo/MONDO_0004995
T256 43048-43056 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T257 43197-43218 Disease denotes chronic renal disease http://purl.obolibrary.org/obo/MONDO_0005300
T258 43205-43218 Disease denotes renal disease http://purl.obolibrary.org/obo/MONDO_0002118|http://purl.obolibrary.org/obo/MONDO_0005240
T260 43385-43407 Disease denotes chronic renal diseases http://purl.obolibrary.org/obo/MONDO_0005300
T261 43429-43433 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T262 43596-43602 Disease denotes asthma http://purl.obolibrary.org/obo/MONDO_0004979
T263 43708-43714 Disease denotes asthma http://purl.obolibrary.org/obo/MONDO_0004979
T264 43975-43979 Disease denotes ARDS http://purl.obolibrary.org/obo/MONDO_0006502
T265 44035-44043 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T266 44234-44238 Disease denotes ARDS http://purl.obolibrary.org/obo/MONDO_0006502
T267 44276-44284 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T268 44328-44331 Disease denotes flu http://purl.obolibrary.org/obo/MONDO_0005812
T269 44502-44511 Disease denotes pneumonia http://purl.obolibrary.org/obo/MONDO_0005249
T270 44793-44801 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T271 45228-45236 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T272 45552-45583 Disease denotes pulmonary arterial hypertension http://purl.obolibrary.org/obo/MONDO_0015924|http://purl.obolibrary.org/obo/MONDO_0024533
T274 45571-45583 Disease denotes hypertension http://purl.obolibrary.org/obo/MONDO_0005044
T275 45585-45588 Disease denotes PAH http://purl.obolibrary.org/obo/MONDO_0015924
T276 45601-45609 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T277 45601-45605 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T278 45832-45836 Disease denotes ARDS http://purl.obolibrary.org/obo/MONDO_0006502
T279 45838-45841 Disease denotes PAH http://purl.obolibrary.org/obo/MONDO_0015924
T280 45846-45854 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T281 45846-45850 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T282 45855-45865 Disease denotes infections http://purl.obolibrary.org/obo/MONDO_0005550
T283 49774-49797 Disease denotes cardiovascular diseases http://purl.obolibrary.org/obo/MONDO_0004995
T284 49799-49817 Disease denotes metabolic syndrome http://purl.obolibrary.org/obo/MONDO_0004955
T285 49819-49831 Disease denotes inflammation http://purl.obolibrary.org/obo/MONDO_0021166
T286 49853-49861 Disease denotes diabetes http://purl.obolibrary.org/obo/MONDO_0005015
T287 49866-49876 Disease denotes thrombosis http://purl.obolibrary.org/obo/MONDO_0000831
T288 49952-49959 Disease denotes amyloid http://purl.obolibrary.org/obo/MONDO_0019065
T289 49993-50012 Disease denotes Alzheimer’s disease http://purl.obolibrary.org/obo/MONDO_0004975
T290 50156-50181 Disease denotes neurodegenerative disease http://purl.obolibrary.org/obo/MONDO_0005559
T291 50451-50459 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T292 50707-50733 Disease denotes neurodegenerative diseases http://purl.obolibrary.org/obo/MONDO_0005559
T293 50881-50884 Disease denotes FFA http://purl.obolibrary.org/obo/MONDO_0016776
T294 51181-51184 Disease denotes FFA http://purl.obolibrary.org/obo/MONDO_0016776
T295 51338-51350 Disease denotes dyslipidemia http://purl.obolibrary.org/obo/MONDO_0002525
T296 51706-51713 Disease denotes amyloid http://purl.obolibrary.org/obo/MONDO_0019065
T297 51759-51778 Disease denotes Alzheimer’s disease http://purl.obolibrary.org/obo/MONDO_0004975
T298 52320-52323 Disease denotes IBD http://purl.obolibrary.org/obo/MONDO_0005052|http://purl.obolibrary.org/obo/MONDO_0005265
T300 52325-52329 Disease denotes ARDS http://purl.obolibrary.org/obo/MONDO_0006502
T301 52334-52342 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T302 52434-52438 Disease denotes ARDS http://purl.obolibrary.org/obo/MONDO_0006502
T303 52685-52689 Disease denotes ARDS http://purl.obolibrary.org/obo/MONDO_0006502
T304 52784-52788 Disease denotes ARDS http://purl.obolibrary.org/obo/MONDO_0006502
T305 52814-52832 Disease denotes multiorgan failure http://purl.obolibrary.org/obo/MONDO_0043726
T306 53104-53123 Disease denotes respiratory failure http://purl.obolibrary.org/obo/MONDO_0021113
T307 53246-53252 Disease denotes injury http://purl.obolibrary.org/obo/MONDO_0021178
T308 53363-53385 Disease denotes pulmonary hypertension http://purl.obolibrary.org/obo/MONDO_0005149
T309 53373-53385 Disease denotes hypertension http://purl.obolibrary.org/obo/MONDO_0005044
T310 53745-53753 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T311 54357-54361 Disease denotes clam http://purl.obolibrary.org/obo/MONDO_0011948
T312 57475-57483 Disease denotes acidosis http://purl.obolibrary.org/obo/MONDO_0006022
T313 57507-57511 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T314 58795-58821 Disease denotes increase of blood pressure http://purl.obolibrary.org/obo/MONDO_0005044
T315 59640-59646 Disease denotes injury http://purl.obolibrary.org/obo/MONDO_0021178
T316 60191-60203 Disease denotes inflammation http://purl.obolibrary.org/obo/MONDO_0021166
T317 60673-60694 Disease denotes myocardial infarction http://purl.obolibrary.org/obo/MONDO_0005068
T318 61121-61142 Disease denotes myocardial infarction http://purl.obolibrary.org/obo/MONDO_0005068
T319 61194-61202 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T320 61538-61545 Disease denotes colitis http://purl.obolibrary.org/obo/MONDO_0005292
T321 64682-64690 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T322 65271-65279 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T323 65482-65490 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T324 65491-65500 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T325 65836-65847 Disease denotes arrhythmias http://purl.obolibrary.org/obo/MONDO_0007263
T326 65872-65883 Disease denotes hypotension http://purl.obolibrary.org/obo/MONDO_0005468
T327 65922-65937 Disease denotes agranulocytosis http://purl.obolibrary.org/obo/MONDO_0001609
T328 65963-65973 Disease denotes infections http://purl.obolibrary.org/obo/MONDO_0005550
T329 66130-66151 Disease denotes renal artery diseases http://purl.obolibrary.org/obo/MONDO_0002286
T330 67811-67819 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T331 67811-67815 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T332 67917-67925 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T333 67917-67921 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T334 70066-70084 Disease denotes SARS-CoV infection http://purl.obolibrary.org/obo/MONDO_0005091
T335 70066-70070 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T336 70075-70084 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T337 70186-70194 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T338 70186-70190 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T339 70263-70278 Disease denotes viral infection http://purl.obolibrary.org/obo/MONDO_0005108
T340 70269-70278 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T341 70371-70379 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T342 70393-70397 Disease denotes ARDS http://purl.obolibrary.org/obo/MONDO_0006502
T343 70402-70405 Disease denotes PAH http://purl.obolibrary.org/obo/MONDO_0015924
T344 70687-70695 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T345 70744-70748 Disease denotes ARDS http://purl.obolibrary.org/obo/MONDO_0006502
T346 70753-70756 Disease denotes PAH http://purl.obolibrary.org/obo/MONDO_0015924
T347 70972-70980 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T348 71000-71008 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T349 71060-71072 Disease denotes hypertension http://purl.obolibrary.org/obo/MONDO_0005044
T350 71074-71082 Disease denotes diabetes http://purl.obolibrary.org/obo/MONDO_0005015
T351 71316-71328 Disease denotes hypertension http://purl.obolibrary.org/obo/MONDO_0005044
T352 71888-71900 Disease denotes hypertension http://purl.obolibrary.org/obo/MONDO_0005044
T353 71902-71910 Disease denotes diabetes http://purl.obolibrary.org/obo/MONDO_0005015
T354 71912-71924 Disease denotes dyslipidemia http://purl.obolibrary.org/obo/MONDO_0002525
T355 72111-72119 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T356 72600-72603 Disease denotes ARB http://purl.obolibrary.org/obo/MONDO_0012733
T357 72899-72902 Disease denotes ARB http://purl.obolibrary.org/obo/MONDO_0012733
T358 73248-73251 Disease denotes ARB http://purl.obolibrary.org/obo/MONDO_0012733
T359 73376-73379 Disease denotes ARB http://purl.obolibrary.org/obo/MONDO_0012733
T360 73466-73469 Disease denotes AT1 http://purl.obolibrary.org/obo/MONDO_0008840
T361 73643-73651 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T362 73793-73796 Disease denotes ARB http://purl.obolibrary.org/obo/MONDO_0012733
T363 73933-73936 Disease denotes ARB http://purl.obolibrary.org/obo/MONDO_0012733
T364 73966-73974 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T365 73992-73995 Disease denotes ARB http://purl.obolibrary.org/obo/MONDO_0012733
T366 74069-74077 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T367 74141-74144 Disease denotes ARB http://purl.obolibrary.org/obo/MONDO_0012733
T368 74189-74197 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T369 74207-74210 Disease denotes ARB http://purl.obolibrary.org/obo/MONDO_0012733
T370 74296-74299 Disease denotes ARB http://purl.obolibrary.org/obo/MONDO_0012733
T371 74417-74425 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T372 74475-74478 Disease denotes ARB http://purl.obolibrary.org/obo/MONDO_0012733
T373 74835-74843 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T374 75034-75037 Disease denotes ARB http://purl.obolibrary.org/obo/MONDO_0012733
T375 75104-75108 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T376 75176-75192 Disease denotes face the disease http://purl.obolibrary.org/obo/MONDO_0044987
T377 75264-75272 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T378 76048-76054 Disease denotes asthma http://purl.obolibrary.org/obo/MONDO_0004979
T379 76065-76082 Disease denotes allergic diseases http://purl.obolibrary.org/obo/MONDO_0005271
T380 76065-76073 Disease denotes allergic http://purl.obolibrary.org/obo/MONDO_0004980
T381 76114-76122 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T382 76300-76323 Disease denotes cardiovascular diseases http://purl.obolibrary.org/obo/MONDO_0004995
T383 76329-76355 Disease denotes inflammatory bowel disease http://purl.obolibrary.org/obo/MONDO_0005265
T384 76489-76497 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T385 76529-76548 Disease denotes atrial fibrillation http://purl.obolibrary.org/obo/MONDO_0004981
T386 76677-76689 Disease denotes hypertension http://purl.obolibrary.org/obo/MONDO_0005044
T387 76705-76721 Disease denotes vascular disease http://purl.obolibrary.org/obo/MONDO_0005385
T388 76874-76882 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T389 76953-76957 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T390 77080-77095 Disease denotes viral infection http://purl.obolibrary.org/obo/MONDO_0005108
T391 77086-77095 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T392 77302-77310 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T393 77401-77409 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T394 77506-77527 Disease denotes chronic renal disease http://purl.obolibrary.org/obo/MONDO_0005300
T395 77514-77527 Disease denotes renal disease http://purl.obolibrary.org/obo/MONDO_0002118|http://purl.obolibrary.org/obo/MONDO_0005240
T397 77531-77539 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T398 77719-77741 Disease denotes chronic kidney disease http://purl.obolibrary.org/obo/MONDO_0005300
T399 77727-77741 Disease denotes kidney disease http://purl.obolibrary.org/obo/MONDO_0001343|http://purl.obolibrary.org/obo/MONDO_0005240
T401 77772-77794 Disease denotes cardiovascular disease http://purl.obolibrary.org/obo/MONDO_0004995
T402 77933-77944 Disease denotes proteinuria http://purl.obolibrary.org/obo/MONDO_0003634
T403 78011-78033 Disease denotes chronic kidney disease http://purl.obolibrary.org/obo/MONDO_0005300
T404 78019-78033 Disease denotes kidney disease http://purl.obolibrary.org/obo/MONDO_0001343|http://purl.obolibrary.org/obo/MONDO_0005240
T406 78127-78149 Disease denotes chronic renal diseases http://purl.obolibrary.org/obo/MONDO_0005300
T407 78170-78174 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T408 78357-78379 Disease denotes chronic renal diseases http://purl.obolibrary.org/obo/MONDO_0005300
T409 78458-78461 Disease denotes ARB http://purl.obolibrary.org/obo/MONDO_0012733
T410 78657-78665 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T411 78763-78773 Disease denotes infections http://purl.obolibrary.org/obo/MONDO_0005550
T412 78784-78792 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T413 78784-78788 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T414 78874-78882 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T415 78874-78878 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T416 78885-78894 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T417 79154-79166 Disease denotes hypertension http://purl.obolibrary.org/obo/MONDO_0005044
T418 79168-79180 Disease denotes dyslipidemia http://purl.obolibrary.org/obo/MONDO_0002525
T419 79182-79197 Disease denotes type 2 diabetes http://purl.obolibrary.org/obo/MONDO_0005148
T420 79189-79197 Disease denotes diabetes http://purl.obolibrary.org/obo/MONDO_0005015
T421 79528-79536 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T422 79565-79588 Disease denotes obstructive sleep apnea http://purl.obolibrary.org/obo/MONDO_0007147
T423 79577-79588 Disease denotes sleep apnea http://purl.obolibrary.org/obo/MONDO_0005296
T424 79590-79593 Disease denotes OSA http://purl.obolibrary.org/obo/MONDO_0007147
T425 79638-79641 Disease denotes OSA http://purl.obolibrary.org/obo/MONDO_0007147
T426 79646-79654 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T427 79702-79705 Disease denotes OSA http://purl.obolibrary.org/obo/MONDO_0007147
T428 79709-79717 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T429 79772-79775 Disease denotes OSA http://purl.obolibrary.org/obo/MONDO_0007147
T430 79829-79832 Disease denotes OSA http://purl.obolibrary.org/obo/MONDO_0007147
T431 79967-80003 Disease denotes hypertension, cardiovascular disease http://purl.obolibrary.org/obo/MONDO_0001302
T432 79967-79979 Disease denotes hypertension http://purl.obolibrary.org/obo/MONDO_0005044
T433 79981-80003 Disease denotes cardiovascular disease http://purl.obolibrary.org/obo/MONDO_0004995
T434 80005-80013 Disease denotes diabetes http://purl.obolibrary.org/obo/MONDO_0005015
T435 80015-80022 Disease denotes obesity http://purl.obolibrary.org/obo/MONDO_0011122
T436 80036-80048 Disease denotes inflammation http://purl.obolibrary.org/obo/MONDO_0021166
T437 80240-80243 Disease denotes OSA http://purl.obolibrary.org/obo/MONDO_0007147
T438 80291-80299 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T439 80291-80295 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T440 80302-80311 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T441 80316-80319 Disease denotes OSA http://purl.obolibrary.org/obo/MONDO_0007147
T442 80540-80543 Disease denotes OSA http://purl.obolibrary.org/obo/MONDO_0007147
T443 80764-80772 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T444 81224-81232 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T445 81224-81228 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T446 81277-81280 Disease denotes flu http://purl.obolibrary.org/obo/MONDO_0005812
T447 81307-81316 Disease denotes influenza http://purl.obolibrary.org/obo/MONDO_0005812
T448 81370-81381 Disease denotes common cold http://purl.obolibrary.org/obo/MONDO_0005709
T449 81518-81521 Disease denotes flu http://purl.obolibrary.org/obo/MONDO_0005812
T450 81631-81639 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T451 81631-81635 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T452 81689-81697 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T453 81689-81693 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T454 81700-81709 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T455 82009-82025 Disease denotes virus infections http://purl.obolibrary.org/obo/MONDO_0005108
T456 82037-82045 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T457 82037-82041 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T458 82341-82349 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T459 82476-82484 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T460 82476-82480 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T461 82487-82496 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T462 82573-82581 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T463 82597-82605 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T464 82597-82601 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T465 82713-82721 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T466 82876-82880 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T467 82994-83002 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T468 82994-82998 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T469 83076-83084 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T470 83076-83080 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T471 83143-83151 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T472 83143-83147 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T473 83181-83187 Disease denotes asthma http://purl.obolibrary.org/obo/MONDO_0004979
T474 83249-83257 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T475 83249-83253 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T476 83461-83479 Disease denotes SARS-CoV infection http://purl.obolibrary.org/obo/MONDO_0005091
T477 83461-83465 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T478 83470-83479 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T479 83506-83512 Disease denotes asthma http://purl.obolibrary.org/obo/MONDO_0004979
T480 83572-83590 Disease denotes SARS-CoV infection http://purl.obolibrary.org/obo/MONDO_0005091
T481 83572-83576 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T482 83581-83590 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T483 83830-83839 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T484 83929-83940 Disease denotes hypotension http://purl.obolibrary.org/obo/MONDO_0005468
T485 83951-83959 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T486 84088-84096 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T487 84088-84092 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T488 84553-84561 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T489 84843-84847 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T490 84868-84874 Disease denotes injury http://purl.obolibrary.org/obo/MONDO_0021178
T491 85388-85396 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T492 85388-85392 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T493 85791-85799 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T494 86722-86730 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T495 87382-87390 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T496 87481-87489 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T497 87481-87485 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T498 87688-87694 Disease denotes injury http://purl.obolibrary.org/obo/MONDO_0021178
T499 87877-87888 Disease denotes hypotension http://purl.obolibrary.org/obo/MONDO_0005468
T500 87909-87917 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T501 87978-88013 Disease denotes Acute Respiratory distress syndrome http://purl.obolibrary.org/obo/MONDO_0006502
T502 87984-88013 Disease denotes Respiratory distress syndrome http://purl.obolibrary.org/obo/MONDO_0009971
T503 88017-88025 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T504 88045-88076 Disease denotes pulmonary arterial hypertension http://purl.obolibrary.org/obo/MONDO_0015924|http://purl.obolibrary.org/obo/MONDO_0024533
T506 88064-88076 Disease denotes hypertension http://purl.obolibrary.org/obo/MONDO_0005044
T507 88119-88154 Disease denotes Acute Respiratory distress syndrome http://purl.obolibrary.org/obo/MONDO_0006502
T508 88125-88154 Disease denotes Respiratory distress syndrome http://purl.obolibrary.org/obo/MONDO_0009971
T509 88225-88229 Disease denotes ARDS http://purl.obolibrary.org/obo/MONDO_0006502
T510 88323-88327 Disease denotes ARDS http://purl.obolibrary.org/obo/MONDO_0006502
T511 88397-88403 Disease denotes trauma http://purl.obolibrary.org/obo/MONDO_0021178
T512 88405-88423 Disease denotes acute pancreatitis http://purl.obolibrary.org/obo/MONDO_0006515
T513 88411-88423 Disease denotes pancreatitis http://purl.obolibrary.org/obo/MONDO_0004982
T514 88428-88438 Disease denotes pneumonias http://purl.obolibrary.org/obo/MONDO_0005249
T515 88449-88465 Disease denotes virus infections http://purl.obolibrary.org/obo/MONDO_0005108
T516 88474-88478 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T517 88493-88502 Disease denotes influenza http://purl.obolibrary.org/obo/MONDO_0005812
T518 88575-88579 Disease denotes ARDS http://purl.obolibrary.org/obo/MONDO_0006502
T519 88636-88640 Disease denotes ARDS http://purl.obolibrary.org/obo/MONDO_0006502
T520 88784-88788 Disease denotes ARDS http://purl.obolibrary.org/obo/MONDO_0006502
T521 88978-88982 Disease denotes ARDS http://purl.obolibrary.org/obo/MONDO_0006502
T522 89031-89034 Disease denotes PAH http://purl.obolibrary.org/obo/MONDO_0015924
T523 89097-89105 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T524 89296-89300 Disease denotes ARDS http://purl.obolibrary.org/obo/MONDO_0006502
T525 89558-89562 Disease denotes ARDS http://purl.obolibrary.org/obo/MONDO_0006502
T526 89614-89618 Disease denotes ARDS http://purl.obolibrary.org/obo/MONDO_0006502
T527 91523-91527 Disease denotes ARDS http://purl.obolibrary.org/obo/MONDO_0006502
T528 92163-92167 Disease denotes ARDS http://purl.obolibrary.org/obo/MONDO_0006502
T529 92885-92889 Disease denotes ARDS http://purl.obolibrary.org/obo/MONDO_0006502
T530 93299-93303 Disease denotes ARDS http://purl.obolibrary.org/obo/MONDO_0006502
T531 93501-93505 Disease denotes ARDS http://purl.obolibrary.org/obo/MONDO_0006502
T532 93904-93908 Disease denotes ARDS http://purl.obolibrary.org/obo/MONDO_0006502
T533 94509-94513 Disease denotes ARDS http://purl.obolibrary.org/obo/MONDO_0006502
T534 94714-94718 Disease denotes ARDS http://purl.obolibrary.org/obo/MONDO_0006502
T535 94869-94873 Disease denotes ARDS http://purl.obolibrary.org/obo/MONDO_0006502
T536 95182-95185 Disease denotes PAH http://purl.obolibrary.org/obo/MONDO_0015924
T537 95190-95214 Disease denotes coronary atherosclerosis http://purl.obolibrary.org/obo/MONDO_0021661
T538 95199-95214 Disease denotes atherosclerosis http://purl.obolibrary.org/obo/MONDO_0005311
T539 95414-95437 Disease denotes coronary artery disease http://purl.obolibrary.org/obo/MONDO_0005010
T540 95423-95437 Disease denotes artery disease http://purl.obolibrary.org/obo/MONDO_0000473
T541 95570-95573 Disease denotes PAH http://purl.obolibrary.org/obo/MONDO_0015924
T542 95925-95933 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T543 96026-96034 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T544 96217-96225 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T545 96217-96221 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T546 96987-96994 Disease denotes colitis http://purl.obolibrary.org/obo/MONDO_0005292
T547 97887-97895 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T548 98112-98120 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T549 98455-98463 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T550 98698-98706 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T551 98698-98702 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T552 99292-99295 Disease denotes DLM http://purl.obolibrary.org/obo/MONDO_0016745
T553 99473-99480 Disease denotes sterile http://purl.obolibrary.org/obo/MONDO_0005047
T554 99645-99648 Disease denotes DLM http://purl.obolibrary.org/obo/MONDO_0016745
T555 100140-100153 Disease denotes inflammations http://purl.obolibrary.org/obo/MONDO_0021166
T556 100155-100181 Disease denotes Inflammatory bowel disease http://purl.obolibrary.org/obo/MONDO_0005265
T557 100183-100192 Disease denotes gastritis http://purl.obolibrary.org/obo/MONDO_0004966
T558 100197-100204 Disease denotes colitis http://purl.obolibrary.org/obo/MONDO_0005292
T559 101228-101240 Disease denotes inflammation http://purl.obolibrary.org/obo/MONDO_0021166
T560 101319-101323 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T561 102108-102116 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T562 102904-102912 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T563 103668-103680 Disease denotes hypertension http://purl.obolibrary.org/obo/MONDO_0005044
T564 103759-103767 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T565 103803-103811 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T566 103803-103807 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T567 103814-103823 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T568 103869-103877 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T569 104352-104360 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T570 104352-104356 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T571 104363-104372 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T572 105028-105036 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T573 105028-105032 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T574 105039-105048 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T575 105327-105335 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T576 105402-105410 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T577 105402-105406 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T578 105413-105422 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T579 105545-105549 Disease denotes ARDS http://purl.obolibrary.org/obo/MONDO_0006502
T580 105551-105554 Disease denotes PAH http://purl.obolibrary.org/obo/MONDO_0015924
T581 105611-105626 Disease denotes cardiac failure http://purl.obolibrary.org/obo/MONDO_0005252
T582 105741-105745 Disease denotes ARDS http://purl.obolibrary.org/obo/MONDO_0006502
T583 105750-105753 Disease denotes PAH http://purl.obolibrary.org/obo/MONDO_0015924
T584 105777-105800 Disease denotes coronary artery disease http://purl.obolibrary.org/obo/MONDO_0005010
T585 105786-105800 Disease denotes artery disease http://purl.obolibrary.org/obo/MONDO_0000473
T586 106005-106027 Disease denotes coronary heart disease http://purl.obolibrary.org/obo/MONDO_0005010
T587 106014-106027 Disease denotes heart disease http://purl.obolibrary.org/obo/MONDO_0005267
T588 106765-106779 Disease denotes lead poisoning http://purl.obolibrary.org/obo/MONDO_0018019
T589 106770-106779 Disease denotes poisoning http://purl.obolibrary.org/obo/MONDO_0029000
T590 107697-107711 Disease denotes lead poisoning http://purl.obolibrary.org/obo/MONDO_0018019
T591 107702-107711 Disease denotes poisoning http://purl.obolibrary.org/obo/MONDO_0029000
T592 108185-108195 Disease denotes poisonings http://purl.obolibrary.org/obo/MONDO_0029000
T593 108911-108919 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T594 109026-109034 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T595 109354-109364 Disease denotes thrombosis http://purl.obolibrary.org/obo/MONDO_0000831
T596 109566-109574 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T597 110060-110068 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T598 110494-110502 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T599 110545-110556 Disease denotes hypotension http://purl.obolibrary.org/obo/MONDO_0005468
T600 111024-111036 Disease denotes inflammation http://purl.obolibrary.org/obo/MONDO_0021166
T601 111237-111245 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T602 111237-111241 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T603 111248-111257 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T604 111330-111338 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T605 111399-111402 Disease denotes flu http://purl.obolibrary.org/obo/MONDO_0005812
T606 111561-111569 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T607 111642-111650 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T608 113771-113773 Disease denotes he http://purl.obolibrary.org/obo/MONDO_0017319
T609 114082-114090 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T610 114082-114086 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T611 114160-114168 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T612 114160-114164 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T1 100003-100009 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes humans
T2 100059-100065 http://purl.obolibrary.org/obo/UBERON_0000473 denotes tested
T3 100124-100139 http://purl.obolibrary.org/obo/UBERON_0001555 denotes digestive tract
T4 100258-100259 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T5 100277-100284 http://purl.obolibrary.org/obo/UBERON_0000473 denotes testing
T6 100629-100634 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T7 100629-100634 http://www.ebi.ac.uk/efo/EFO_0000296 denotes blood
T8 100811-100817 http://purl.obolibrary.org/obo/CLO_0001658 denotes active
T9 100851-100852 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T10 101062-101066 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T11 101062-101066 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T12 101096-101104 http://purl.obolibrary.org/obo/NCBITaxon_2 denotes bacteria
T13 101223-101227 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T14 101223-101227 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T15 101704-101705 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T16 101813-101817 http://www.ebi.ac.uk/efo/EFO_0001410 denotes arms
T17 101860-101861 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T18 102014-102022 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T19 102293-102301 http://purl.obolibrary.org/obo/CLO_0001658 denotes actively
T20 102318-102322 http://purl.obolibrary.org/obo/UBERON_0001456 denotes face
T21 102438-102440 http://purl.obolibrary.org/obo/CLO_0050475 denotes my
T22 102672-102673 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T23 102740-102745 http://purl.obolibrary.org/obo/UBERON_0000948 denotes heart
T24 102740-102745 http://purl.obolibrary.org/obo/UBERON_0007100 denotes heart
T25 102740-102745 http://purl.obolibrary.org/obo/UBERON_0015228 denotes heart
T26 102740-102745 http://www.ebi.ac.uk/efo/EFO_0000815 denotes heart
T27 102746-102750 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T28 102746-102750 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T29 102751-102756 http://purl.obolibrary.org/obo/UBERON_0002107 denotes liver
T30 102751-102756 http://www.ebi.ac.uk/efo/EFO_0000887 denotes liver
T31 102757-102766 http://purl.obolibrary.org/obo/UBERON_0000160 denotes intestine
T32 102757-102766 http://www.ebi.ac.uk/efo/EFO_0000834 denotes intestine
T33 102767-102773 http://purl.obolibrary.org/obo/UBERON_0002113 denotes kidney
T34 102767-102773 http://www.ebi.ac.uk/efo/EFO_0000927 denotes kidney
T35 102767-102773 http://www.ebi.ac.uk/efo/EFO_0000929 denotes kidney
T36 102774-102787 http://purl.obolibrary.org/obo/UBERON_0002405 denotes immune system
T37 102788-102793 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T38 102788-102793 http://www.ebi.ac.uk/efo/EFO_0000296 denotes blood
T39 102935-102940 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T40 102935-102940 http://www.ebi.ac.uk/efo/EFO_0000296 denotes blood
T41 102966-102974 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T42 103013-103021 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T43 103025-103030 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T44 103031-103037 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T45 103076-103079 http://purl.obolibrary.org/obo/CLO_0001046 denotes 116
T46 103098-103108 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T47 103163-103171 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T48 103182-103186 http://purl.obolibrary.org/obo/UBERON_0001456 denotes face
T49 103230-103231 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T50 103346-103354 http://purl.obolibrary.org/obo/CLO_0001658 denotes Activity
T51 103464-103472 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T52 103754-103758 http://purl.obolibrary.org/obo/UBERON_0001456 denotes face
T53 103914-103918 http://www.ebi.ac.uk/efo/EFO_0001410 denotes arms
T54 103961-103962 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T55 104122-104125 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T56 104208-104209 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T57 104388-104391 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T58 104472-104473 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T59 104509-104513 http://www.ebi.ac.uk/efo/EFO_0001410 denotes arms
T60 104894-104902 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T61 104932-104936 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T62 105105-105109 http://www.ebi.ac.uk/efo/EFO_0001410 denotes arms
T63 105464-105468 http://www.ebi.ac.uk/efo/EFO_0001410 denotes arms
T64 105679-105680 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T65 105786-105792 http://purl.obolibrary.org/obo/UBERON_0001637 denotes artery
T66 105786-105792 http://www.ebi.ac.uk/efo/EFO_0000814 denotes artery
T67 105843-105847 http://www.ebi.ac.uk/efo/EFO_0001410 denotes arms
T68 105934-105935 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T69 106014-106019 http://purl.obolibrary.org/obo/UBERON_0000948 denotes heart
T70 106014-106019 http://purl.obolibrary.org/obo/UBERON_0007100 denotes heart
T71 106014-106019 http://purl.obolibrary.org/obo/UBERON_0015228 denotes heart
T72 106014-106019 http://www.ebi.ac.uk/efo/EFO_0000815 denotes heart
T73 106340-106350 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T74 106591-106592 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T75 106615-106616 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T76 106860-106882 http://purl.obolibrary.org/obo/UBERON_0005409 denotes gastrointestinal tract
T77 107077-107083 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T78 107110-107120 http://purl.obolibrary.org/obo/UBERON_0000160 denotes intestinal
T79 107110-107120 http://www.ebi.ac.uk/efo/EFO_0000834 denotes intestinal
T80 107187-107195 http://purl.obolibrary.org/obo/OBI_0100026 denotes organism
T81 107187-107195 http://purl.obolibrary.org/obo/UBERON_0000468 denotes organism
T82 107282-107283 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T83 107363-107364 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T84 107834-107839 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T85 107834-107839 http://www.ebi.ac.uk/efo/EFO_0000296 denotes blood
T86 107860-107864 http://purl.obolibrary.org/obo/CLO_0003535 denotes g/m2
T87 107995-107996 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T88 108121-108124 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T89 108207-108211 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T90 108207-108211 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T91 108753-108756 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T92 108757-108758 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T93 109055-109056 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T94 109337-109341 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T95 109337-109341 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T96 109390-109400 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T97 109578-109579 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T98 109761-109762 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T99 109785-109786 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T100 110135-110141 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T101 110341-110349 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T102 110423-110431 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T103 110923-110928 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T104 110923-110928 http://www.ebi.ac.uk/efo/EFO_0000296 denotes blood
T105 110994-111002 http://purl.obolibrary.org/obo/PR_000018263 denotes peptides
T106 111043-111046 http://purl.obolibrary.org/obo/PR_000001343 denotes aim
T107 111107-111117 http://purl.obolibrary.org/obo/CL_0000066 denotes epithelial
T108 111118-111123 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T109 111390-111391 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T110 111404-111405 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T111 111610-111611 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T112 111823-111826 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T113 111856-111864 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T114 112033-112034 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T115 112218-112220 http://purl.obolibrary.org/obo/CLO_0050475 denotes my
T116 112273-112274 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T117 112297-112298 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T118 112839-112842 http://purl.obolibrary.org/obo/CLO_0002742 denotes del
T119 113069-113074 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T120 113086-113087 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T121 113103-113104 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T122 113188-113192 http://purl.obolibrary.org/obo/UBERON_0001456 denotes face
T123 113299-113301 http://purl.obolibrary.org/obo/CLO_0050475 denotes my
T124 113386-113391 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T125 113499-113501 http://purl.obolibrary.org/obo/CLO_0050475 denotes my
T126 113774-113777 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T127 113852-113856 http://www.ebi.ac.uk/efo/EFO_0001410 denotes arms
T128 113947-113957 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T129 114219-114229 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T1177 441-447 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes humans
T48692 457-458 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T76251 865-869 http://www.ebi.ac.uk/efo/EFO_0001410 denotes arms
T92165 1782-1791 http://www.ebi.ac.uk/efo/EFO_0000876 denotes extremely
T23402 1855-1856 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T30677 2060-2061 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T96031 2107-2111 http://purl.obolibrary.org/obo/CLO_0053704 denotes IL-8
T99826 2381-2384 http://purl.obolibrary.org/obo/CLO_0001414 denotes 548
T43843 2955-2960 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T60553 3079-3080 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T56639 3107-3112 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T28761 3209-3211 http://purl.obolibrary.org/obo/CLO_0050510 denotes 18
T99781 3251-3253 http://purl.obolibrary.org/obo/CLO_0053733 denotes 11
T70533 3401-3402 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T72708 3795-3801 http://purl.obolibrary.org/obo/UBERON_0002113 denotes kidney
T15863 3795-3801 http://www.ebi.ac.uk/efo/EFO_0000927 denotes kidney
T37184 3795-3801 http://www.ebi.ac.uk/efo/EFO_0000929 denotes kidney
T27253 3986-3987 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T11956 4081-4086 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T59818 4125-4131 http://purl.obolibrary.org/obo/UBERON_0001005 denotes airway
T25048 4132-4142 http://purl.obolibrary.org/obo/CL_0000066 denotes epithelial
T45947 4143-4148 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T10170 4162-4179 http://purl.obolibrary.org/obo/CL_0000115 denotes endothelial cells
T36367 4208-4209 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T94559 4249-4253 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T18915 4249-4253 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T49004 4308-4310 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T42150 4374-4377 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T92578 4412-4422 http://purl.obolibrary.org/obo/CLO_0000031 denotes cell lines
T47002 4444-4448 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T41775 4444-4448 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T33694 4449-4454 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T62919 4612-4616 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T14814 4628-4633 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T56060 4634-4640 http://purl.obolibrary.org/obo/UBERON_0001005 denotes airway
T1792 4656-4662 http://purl.obolibrary.org/obo/UBERON_0001005 denotes airway
T85406 4750-4753 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T60699 4804-4814 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T15128 5203-5208 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T47491 5232-5237 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T61686 5238-5244 http://purl.obolibrary.org/obo/UBERON_0001005 denotes airway
T23099 5255-5258 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T34964 5306-5314 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T56294 5428-5433 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T5722 5517-5518 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T91276 5675-5683 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T71067 5898-5903 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T32655 6157-6165 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T83841 6334-6336 http://purl.obolibrary.org/obo/CLO_0050507 denotes 22
T42024 6543-6546 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T66445 6588-6596 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T1462 6629-6644 http://purl.obolibrary.org/obo/GO_0043234 denotes protein complex
T66948 6703-6711 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T82513 6766-6767 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T95692 6898-6906 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T65495 6923-6924 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T74464 6983-6987 http://purl.obolibrary.org/obo/OGG_0000000002 denotes gene
T56108 7010-7015 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T38701 7026-7031 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T36055 7117-7118 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T77642 7191-7192 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T15238 7260-7263 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T38031 7315-7325 http://purl.obolibrary.org/obo/UBERON_0000483 denotes epithelium
T71674 7423-7433 http://purl.obolibrary.org/obo/CL_0000066 denotes epithelial
T31054 7434-7439 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T46684 7714-7718 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T19001 7714-7718 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T91433 7837-7854 http://purl.obolibrary.org/obo/GO_0043234 denotes protein complexes
T66620 7961-7963 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T76112 8237-8241 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T85916 8242-8248 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T42262 8249-8257 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T4712 8362-8364 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T12859 8379-8381 http://purl.obolibrary.org/obo/CLO_0008922 denotes S2
T72988 8379-8381 http://purl.obolibrary.org/obo/CLO_0050052 denotes S2
T53244 8496-8498 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T93889 8499-8508 http://purl.obolibrary.org/obo/UBERON_0000033 denotes heads and
T73899 8499-8508 http://www.ebi.ac.uk/efo/EFO_0000964 denotes heads and
T50671 8509-8510 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T1263 8520-8522 http://purl.obolibrary.org/obo/CLO_0008922 denotes S2
T61883 8520-8522 http://purl.obolibrary.org/obo/CLO_0050052 denotes S2
T24540 8579-8581 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T30598 8836-8838 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T86794 8951-8953 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T58803 8975-8977 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T15028 9029-9031 http://purl.obolibrary.org/obo/CLO_0008922 denotes S2
T80157 9029-9031 http://purl.obolibrary.org/obo/CLO_0050052 denotes S2
T19942 9059-9067 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T91194 9098-9102 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T77366 9237-9238 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T97236 9298-9301 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T81091 9363-9364 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T93457 9417-9422 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T78563 9444-9445 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T86342 9719-9720 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T89948 9721-9729 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T27116 9835-9839 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T53807 9840-9848 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T96275 9857-9858 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T91518 9859-9867 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T1576 10031-10035 http://www.ebi.ac.uk/efo/EFO_0000967 denotes neck
T13416 10066-10067 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T7903 10172-10175 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T48778 10250-10254 http://www.ebi.ac.uk/efo/EFO_0000967 denotes neck
T3704 10365-10367 http://purl.obolibrary.org/obo/CLO_0008922 denotes S2
T6824 10365-10367 http://purl.obolibrary.org/obo/CLO_0050052 denotes S2
T65411 10519-10523 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T93631 10532-10541 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membranes
T36180 10543-10544 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T98795 10592-10597 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T83678 10663-10668 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T26776 10683-10687 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T81513 10689-10690 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T17871 10776-10778 http://purl.obolibrary.org/obo/CLO_0008922 denotes S2
T75662 10776-10778 http://purl.obolibrary.org/obo/CLO_0050052 denotes S2
T61344 10856-10861 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T2057 10876-10882 http://purl.obolibrary.org/obo/CLO_0001658 denotes active
T72343 10902-10904 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T25654 10927-10929 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T15557 11124-11129 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T67356 11138-11141 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T824 11239-11249 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T96980 11348-11350 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T60119 11420-11422 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T36399 11478-11484 http://purl.obolibrary.org/obo/CLO_0001658 denotes active
T97656 11623-11631 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T10969 11669-11675 http://purl.obolibrary.org/obo/UBERON_0003103 denotes organs
T24009 11684-11689 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T60151 11723-11731 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T130 11934-11940 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T131 12086-12092 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T132 12209-12215 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T133 12463-12469 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T134 12533-12534 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T135 12676-12678 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T136 12698-12699 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T137 12745-12747 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T138 12815-12817 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T139 12836-12838 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T140 12926-12928 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T141 12964-12966 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T142 13092-13094 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T143 13282-13284 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T144 13371-13372 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T145 13407-13416 http://purl.obolibrary.org/obo/OBI_0000245 denotes organized
T146 13483-13488 http://www.ebi.ac.uk/efo/EFO_0001410 denotes armed
T147 13651-13657 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T148 13692-13693 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T149 14048-14051 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T150 14064-14071 http://purl.obolibrary.org/obo/PR_000018263 denotes peptide
T151 14139-14149 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T152 14175-14183 http://purl.obolibrary.org/obo/PR_000018263 denotes peptides
T153 14457-14467 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T154 14534-14535 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T155 14639-14640 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T156 14761-14771 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T157 14835-14839 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T158 14891-14895 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T159 14891-14895 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T160 14983-14991 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T161 15402-15424 http://purl.obolibrary.org/obo/UBERON_0005409 denotes gastrointestinal tract
T162 15447-15452 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T163 15467-15471 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T164 15467-15471 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T165 15496-15501 http://purl.obolibrary.org/obo/UBERON_0003103 denotes organ
T166 15540-15550 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T167 15626-15636 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T168 15776-15786 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T169 15855-15860 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T170 15855-15860 http://www.ebi.ac.uk/efo/EFO_0000296 denotes blood
T171 15939-15941 http://purl.obolibrary.org/obo/CLO_0001382 denotes 48
T172 15964-15970 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T173 15977-15985 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T174 16225-16230 http://purl.obolibrary.org/obo/UBERON_0000948 denotes heart
T175 16225-16230 http://purl.obolibrary.org/obo/UBERON_0007100 denotes heart
T176 16225-16230 http://purl.obolibrary.org/obo/UBERON_0015228 denotes heart
T177 16225-16230 http://www.ebi.ac.uk/efo/EFO_0000815 denotes heart
T178 16361-16369 http://purl.obolibrary.org/obo/UBERON_0007651 denotes junction
T179 16553-16554 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T180 16609-16615 http://purl.obolibrary.org/obo/UBERON_0001637 denotes artery
T181 16609-16615 http://www.ebi.ac.uk/efo/EFO_0000814 denotes artery
T182 16649-16652 http://purl.obolibrary.org/obo/CLO_0002096 denotes C16
T183 16663-16664 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T184 16767-16777 http://purl.obolibrary.org/obo/UBERON_0002349 denotes myocardium
T185 16848-16856 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T186 16917-16922 http://purl.obolibrary.org/obo/UBERON_0000948 denotes heart
T187 16917-16922 http://purl.obolibrary.org/obo/UBERON_0007100 denotes heart
T188 16917-16922 http://purl.obolibrary.org/obo/UBERON_0015228 denotes heart
T189 16917-16922 http://www.ebi.ac.uk/efo/EFO_0000815 denotes heart
T190 16924-16926 http://purl.obolibrary.org/obo/CLO_0001407 denotes 52
T191 17261-17262 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T192 17287-17297 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T193 17387-17390 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T194 17455-17456 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T195 17457-17462 http://purl.obolibrary.org/obo/CLO_0007836 denotes mouse
T196 17475-17485 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T197 17695-17705 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T198 18086-18092 http://purl.obolibrary.org/obo/UBERON_0002107 denotes livers
T199 18086-18092 http://www.ebi.ac.uk/efo/EFO_0000887 denotes livers
T200 18141-18158 http://purl.obolibrary.org/obo/CL_0000115 denotes endothelial cells
T201 18172-18177 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T202 18280-18285 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T203 18397-18405 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T204 18510-18515 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T205 18510-18515 http://www.ebi.ac.uk/efo/EFO_0000296 denotes blood
T206 18516-18521 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T207 18528-18533 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T208 18572-18580 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T209 18618-18624 http://purl.obolibrary.org/obo/CLO_0001658 denotes active
T210 18702-18707 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T211 18708-18724 http://purl.obolibrary.org/obo/UBERON_0002012 denotes pulmonary artery
T212 18708-18724 http://www.ebi.ac.uk/efo/EFO_0001399 denotes pulmonary artery
T213 18725-18744 http://purl.obolibrary.org/obo/CL_0000192 denotes smooth muscle cells
T214 18763-18767 http://www.ebi.ac.uk/efo/EFO_0001410 denotes arms
T215 18992-19003 http://purl.obolibrary.org/obo/UBERON_0001986 denotes endothelium
T216 19015-19021 http://purl.obolibrary.org/obo/UBERON_0001630 denotes muscle
T217 19015-19021 http://purl.obolibrary.org/obo/UBERON_0005090 denotes muscle
T218 19015-19021 http://www.ebi.ac.uk/efo/EFO_0000801 denotes muscle
T219 19015-19021 http://www.ebi.ac.uk/efo/EFO_0001949 denotes muscle
T220 19025-19030 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T221 19091-19096 http://purl.obolibrary.org/obo/UBERON_0000948 denotes heart
T222 19091-19096 http://purl.obolibrary.org/obo/UBERON_0007100 denotes heart
T223 19091-19096 http://purl.obolibrary.org/obo/UBERON_0015228 denotes heart
T224 19091-19096 http://www.ebi.ac.uk/efo/EFO_0000815 denotes heart
T225 19144-19148 http://www.ebi.ac.uk/efo/EFO_0001410 denotes arms
T226 19174-19175 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T227 19269-19270 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T228 19319-19323 http://www.ebi.ac.uk/efo/EFO_0001410 denotes arms
T229 19412-19422 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T230 19502-19507 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lungs
T231 19586-19591 http://purl.obolibrary.org/obo/CLO_0007836 denotes mouse
T232 19604-19608 http://purl.obolibrary.org/obo/OGG_0000000002 denotes gene
T233 19707-19715 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T234 19967-19970 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T235 20013-20019 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T236 20040-20048 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T237 20053-20059 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T238 20131-20132 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T239 20193-20198 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lungs
T240 20199-20202 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T241 20224-20225 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T242 20287-20297 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T243 20347-20350 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T244 20429-20435 http://purl.obolibrary.org/obo/UBERON_0000948 denotes hearts
T245 20429-20435 http://purl.obolibrary.org/obo/UBERON_0007100 denotes hearts
T246 20429-20435 http://purl.obolibrary.org/obo/UBERON_0015228 denotes hearts
T247 20429-20435 http://www.ebi.ac.uk/efo/EFO_0000815 denotes hearts
T248 20556-20560 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T249 20556-20560 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T250 20636-20637 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T251 20681-20682 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T252 20744-20752 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T253 20761-20765 http://www.ebi.ac.uk/efo/EFO_0001410 denotes arms
T254 21051-21054 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T255 21112-21119 http://purl.obolibrary.org/obo/PR_000018263 denotes peptide
T256 21207-21208 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T257 21209-21214 http://purl.obolibrary.org/obo/UBERON_0000948 denotes heart
T258 21209-21214 http://purl.obolibrary.org/obo/UBERON_0007100 denotes heart
T259 21209-21214 http://purl.obolibrary.org/obo/UBERON_0015228 denotes heart
T260 21209-21214 http://www.ebi.ac.uk/efo/EFO_0000815 denotes heart
T261 21215-21221 http://purl.obolibrary.org/obo/CLO_0001658 denotes active
T262 21222-21229 http://purl.obolibrary.org/obo/PR_000018263 denotes peptide
T263 21287-21293 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T264 21376-21384 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T265 21469-21477 http://purl.obolibrary.org/obo/CLO_0001658 denotes activate
T266 21539-21541 http://purl.obolibrary.org/obo/CLO_0007074 denotes kB
T267 21539-21541 http://purl.obolibrary.org/obo/CLO_0051988 denotes kB
T268 21542-21551 http://purl.obolibrary.org/obo/SO_0000418 denotes signaling
T269 21555-21559 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T270 21555-21559 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T271 21560-21570 http://purl.obolibrary.org/obo/CL_0000057 denotes fibroblast
T272 21678-21682 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T273 21678-21682 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T274 21814-21818 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T275 21814-21818 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T276 21869-21870 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T277 22039-22043 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T278 22039-22043 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T279 22099-22109 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T280 22142-22146 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T281 22147-22155 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T282 22170-22171 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T283 22280-22288 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T284 22464-22468 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T285 22464-22468 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T286 22567-22571 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T287 22662-22666 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T288 22662-22666 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T289 22804-22808 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T290 22804-22808 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T291 23000-23008 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T292 23012-23016 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T293 23012-23016 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T294 23061-23069 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T295 23147-23150 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T296 23205-23210 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lungs
T297 23308-23314 http://purl.obolibrary.org/obo/UBERON_0001005 denotes airway
T298 23343-23347 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T299 23370-23371 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T300 23487-23497 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T301 23542-23543 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T302 23587-23590 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T303 23635-23636 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T304 23747-23757 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T305 23783-23788 http://purl.obolibrary.org/obo/CLO_0007836 denotes mouse
T306 23789-23795 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T307 23868-23878 http://purl.obolibrary.org/obo/SO_0000418 denotes signalling
T308 23880-23882 http://purl.obolibrary.org/obo/CLO_0054055 denotes 71
T309 23935-23940 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T310 24093-24096 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T311 24258-24264 http://purl.obolibrary.org/obo/UBERON_0001005 denotes airway
T312 24330-24338 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T313 24651-24661 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T314 24808-24812 http://www.ebi.ac.uk/efo/EFO_0001410 denotes arms
T315 24858-24859 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T316 24891-24895 http://purl.obolibrary.org/obo/OGG_0000000002 denotes gene
T317 24952-24957 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T318 25001-25002 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T319 25024-25028 http://purl.obolibrary.org/obo/OGG_0000000002 denotes gene
T320 25158-25159 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T321 25538-25554 http://purl.obolibrary.org/obo/CL_0000746 denotes cardiac myocytes
T322 25631-25639 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T323 25719-25727 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T324 25803-25819 http://purl.obolibrary.org/obo/CL_0000746 denotes cardiac myocytes
T325 25828-25834 http://www.ebi.ac.uk/efo/EFO_0000265 denotes aortic
T326 25844-25863 http://purl.obolibrary.org/obo/CL_0000192 denotes smooth muscle cells
T327 25950-25951 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T328 26070-26080 http://purl.obolibrary.org/obo/SO_0000418 denotes signalling
T329 26089-26090 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T330 26252-26259 http://purl.obolibrary.org/obo/PR_000018263 denotes peptide
T331 26409-26417 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T332 26474-26482 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T333 26523-26524 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T334 26573-26577 http://www.ebi.ac.uk/efo/EFO_0001410 denotes arms
T335 26725-26726 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T336 26745-26751 http://purl.obolibrary.org/obo/SO_0000418 denotes signal
T337 26775-26783 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T338 26812-26813 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T339 26832-26838 http://purl.obolibrary.org/obo/SO_0000418 denotes signal
T340 26859-26867 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T341 27158-27162 http://www.ebi.ac.uk/efo/EFO_0001410 denotes arms
T342 27361-27369 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T343 27401-27411 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T344 27453-27457 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T345 27458-27466 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T346 27603-27604 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T347 27782-27785 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T348 27925-27928 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T349 28449-28451 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T350 28452-28454 http://purl.obolibrary.org/obo/CLO_0008922 denotes S2
T351 28452-28454 http://purl.obolibrary.org/obo/CLO_0050052 denotes S2
T352 28576-28577 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T353 28610-28612 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T354 28613-28615 http://purl.obolibrary.org/obo/CLO_0008922 denotes S2
T355 28613-28615 http://purl.obolibrary.org/obo/CLO_0050052 denotes S2
T356 28744-28748 http://purl.obolibrary.org/obo/CLO_0050507 denotes 2 [2
T357 28798-28808 http://purl.obolibrary.org/obo/CL_0000066 denotes epithelial
T358 28809-28815 http://purl.obolibrary.org/obo/UBERON_0001005 denotes airway
T359 28816-28821 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T360 28882-28892 http://purl.obolibrary.org/obo/CL_0000066 denotes epithelial
T361 28893-28898 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T362 29241-29249 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T363 29260-29270 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T364 29595-29599 http://purl.obolibrary.org/obo/UBERON_0002415 denotes tail
T365 29637-29647 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T366 29733-29734 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T367 29888-29898 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T368 30068-30076 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T369 30231-30237 http://purl.obolibrary.org/obo/CLO_0001658 denotes active
T370 30279-30289 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T371 30361-30369 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T372 30378-30382 http://www.ebi.ac.uk/efo/EFO_0001410 denotes arms
T373 30593-30601 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T374 30833-30834 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T375 31093-31106 http://purl.obolibrary.org/obo/UBERON_0002405 denotes immune system
T376 31126-31131 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T377 31168-31176 http://purl.obolibrary.org/obo/OBI_0100026 denotes organism
T378 31168-31176 http://purl.obolibrary.org/obo/UBERON_0000468 denotes organism
T379 31228-31236 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T380 31557-31565 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T381 31645-31649 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T382 31645-31649 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T383 31722-31730 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T384 31739-31743 http://www.ebi.ac.uk/efo/EFO_0001410 denotes arms
T385 32097-32101 http://www.ebi.ac.uk/efo/EFO_0001410 denotes arms
T386 32158-32160 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T387 32225-32230 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T388 32225-32230 http://www.ebi.ac.uk/efo/EFO_0000296 denotes blood
T389 32323-32331 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T390 32440-32445 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T391 32530-32538 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T392 32659-32664 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T393 32714-32718 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T394 32719-32728 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membranes
T395 32748-32756 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T396 32790-32794 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T397 32790-32794 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T398 32968-32969 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T399 33024-33033 http://purl.obolibrary.org/obo/UBERON_0003103 denotes organs in
T400 33206-33213 http://purl.obolibrary.org/obo/PR_000018263 denotes peptide
T401 33390-33398 http://purl.obolibrary.org/obo/PR_000018263 denotes peptides
T402 33960-33968 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T403 34128-34136 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T404 34216-34217 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T405 34255-34258 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T406 34350-34358 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T407 34359-34362 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T408 34391-34394 http://purl.obolibrary.org/obo/CLO_0050884 denotes ten
T409 34510-34518 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T410 34662-34670 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T411 35006-35007 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T412 35183-35187 http://www.ebi.ac.uk/efo/EFO_0001410 denotes arms
T413 35308-35316 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T414 35357-35365 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T415 35442-35452 http://purl.obolibrary.org/obo/CLO_0001658 denotes activities
T416 35548-35549 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T417 35845-35855 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T418 35859-35870 http://purl.obolibrary.org/obo/CLO_0053065 denotes human cells
T419 35911-35914 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T420 36249-36254 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T421 36255-36261 http://www.ebi.ac.uk/efo/EFO_0000265 denotes aortic
T422 36262-36281 http://purl.obolibrary.org/obo/CL_0000192 denotes smooth muscle cells
T423 36332-36334 http://purl.obolibrary.org/obo/CLO_0007074 denotes kB
T424 36332-36334 http://purl.obolibrary.org/obo/CLO_0051988 denotes kB
T425 36453-36454 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T426 36527-36532 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T427 36527-36532 http://www.ebi.ac.uk/efo/EFO_0000296 denotes blood
T428 36697-36705 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T429 36799-36809 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T430 36888-36889 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T431 36904-36905 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T432 36959-36964 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T433 36959-36964 http://www.ebi.ac.uk/efo/EFO_0000296 denotes blood
T434 37041-37042 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T435 37137-37144 http://purl.obolibrary.org/obo/CL_0000084 denotes T cells
T436 37231-37232 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T437 37245-37246 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T438 37322-37323 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T439 37361-37362 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T440 37393-37398 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T441 37393-37398 http://www.ebi.ac.uk/efo/EFO_0000296 denotes blood
T442 37415-37420 http://purl.obolibrary.org/obo/UBERON_0000948 denotes heart
T443 37415-37420 http://purl.obolibrary.org/obo/UBERON_0007100 denotes heart
T444 37415-37420 http://purl.obolibrary.org/obo/UBERON_0015228 denotes heart
T445 37415-37420 http://www.ebi.ac.uk/efo/EFO_0000815 denotes heart
T446 37443-37444 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T447 37496-37497 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T448 37601-37602 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T449 37683-37686 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T450 37811-37817 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes humans
T451 37952-37960 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T452 38140-38141 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T453 38269-38270 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T454 38301-38302 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T455 38368-38369 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T456 38400-38401 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T457 38457-38460 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T458 38461-38462 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T459 38519-38520 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T460 38616-38624 http://purl.obolibrary.org/obo/PR_000018263 denotes peptides
T461 38689-38697 http://purl.obolibrary.org/obo/PR_000018263 denotes peptides
T462 38782-38787 http://purl.obolibrary.org/obo/UBERON_0000948 denotes heart
T463 38782-38787 http://purl.obolibrary.org/obo/UBERON_0007100 denotes heart
T464 38782-38787 http://purl.obolibrary.org/obo/UBERON_0015228 denotes heart
T465 38782-38787 http://www.ebi.ac.uk/efo/EFO_0000815 denotes heart
T466 38789-38796 http://purl.obolibrary.org/obo/UBERON_0002113 denotes kidneys
T467 38789-38796 http://www.ebi.ac.uk/efo/EFO_0000927 denotes kidneys
T468 38789-38796 http://www.ebi.ac.uk/efo/EFO_0000929 denotes kidneys
T469 38798-38803 http://purl.obolibrary.org/obo/UBERON_0002107 denotes liver
T470 38798-38803 http://www.ebi.ac.uk/efo/EFO_0000887 denotes liver
T471 38805-38810 http://purl.obolibrary.org/obo/UBERON_0001155 denotes colon
T472 38812-38827 http://purl.obolibrary.org/obo/UBERON_0002108 denotes small intestine
T473 38829-38833 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T474 38829-38833 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T475 38835-38840 http://purl.obolibrary.org/obo/UBERON_0000955 denotes brain
T476 38835-38840 http://www.ebi.ac.uk/efo/EFO_0000302 denotes brain
T477 38845-38851 http://purl.obolibrary.org/obo/UBERON_0000473 denotes testes
T478 38920-38934 http://purl.obolibrary.org/obo/CL_0000746 denotes cardiomyocytes
T479 38936-38947 http://purl.obolibrary.org/obo/UBERON_0001986 denotes endothelium
T480 38966-38971 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T481 38982-38988 http://purl.obolibrary.org/obo/UBERON_0001005 denotes airway
T482 38989-38994 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T483 39005-39024 http://purl.obolibrary.org/obo/CL_0000192 denotes smooth muscle cells
T484 39040-39052 http://purl.obolibrary.org/obo/CL_0000178 denotes Leydig cells
T485 39127-39137 http://purl.obolibrary.org/obo/CL_0000066 denotes epithelial
T486 39138-39143 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T487 39147-39160 http://purl.obolibrary.org/obo/UBERON_0009773 denotes renal tubules
T488 39162-39166 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T489 39162-39166 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T490 39214-39219 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T491 39266-39276 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T492 39408-39409 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T493 39480-39489 http://purl.obolibrary.org/obo/CLO_0001658 denotes activated
T494 39708-39718 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T495 39994-40000 http://purl.obolibrary.org/obo/CLO_0001658 denotes active
T496 40037-40043 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T497 40227-40233 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T498 40313-40323 http://purl.obolibrary.org/obo/CLO_0001658 denotes activities
T499 40452-40458 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T500 40476-40477 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T501 40615-40616 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T502 40720-40721 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T503 40750-40758 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T504 40794-40800 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T505 40848-40854 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T506 41039-41045 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T507 41078-41084 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T508 41131-41137 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T509 41164-41165 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T510 41355-41361 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T511 41667-41673 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T512 41755-41756 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T513 41834-41835 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T514 41909-41914 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T515 42007-42014 http://purl.obolibrary.org/obo/UBERON_0003100 denotes females
T516 42047-42052 http://purl.obolibrary.org/obo/UBERON_0003101 denotes males
T517 42047-42052 http://www.ebi.ac.uk/efo/EFO_0000970 denotes males
T518 42228-42234 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T519 42318-42323 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T520 42451-42459 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T521 42556-42563 http://purl.obolibrary.org/obo/PR_000018263 denotes peptide
T522 42582-42588 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T523 42762-42763 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T524 42818-42824 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T525 42849-42857 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T526 42943-42949 http://purl.obolibrary.org/obo/UBERON_0002113 denotes kidney
T527 42943-42949 http://www.ebi.ac.uk/efo/EFO_0000927 denotes kidney
T528 42943-42949 http://www.ebi.ac.uk/efo/EFO_0000929 denotes kidney
T529 42975-42976 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T530 43065-43066 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T531 43129-43137 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T532 43373-43381 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T533 43453-43454 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T534 43489-43490 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T535 43521-43522 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T536 43674-43680 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T537 43949-43955 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T538 44095-44104 http://purl.obolibrary.org/obo/CLO_0001658 denotes activated
T539 44196-44206 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T540 44215-44219 http://www.ebi.ac.uk/efo/EFO_0001410 denotes arms
T541 44326-44327 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T542 44416-44417 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T543 44580-44583 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T544 44622-44628 http://purl.obolibrary.org/obo/UBERON_0001630 denotes muscle
T545 44622-44628 http://purl.obolibrary.org/obo/UBERON_0005090 denotes muscle
T546 44622-44628 http://www.ebi.ac.uk/efo/EFO_0000801 denotes muscle
T547 44622-44628 http://www.ebi.ac.uk/efo/EFO_0001949 denotes muscle
T548 44711-44715 http://purl.obolibrary.org/obo/CLO_0053704 denotes IL-8
T549 44872-44876 http://purl.obolibrary.org/obo/CLO_0053704 denotes IL-8
T550 44905-44906 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T551 45117-45126 http://purl.obolibrary.org/obo/CL_0000576 denotes monocytes
T552 45145-45151 http://purl.obolibrary.org/obo/CL_0000084 denotes T cell
T553 45168-45171 http://purl.obolibrary.org/obo/CLO_0054060 denotes 102
T554 45201-45204 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T555 45315-45318 http://purl.obolibrary.org/obo/CLO_0054060 denotes 102
T556 45339-45350 http://www.ebi.ac.uk/efo/EFO_0000296 denotes blood cells
T557 45391-45392 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T558 45478-45482 http://purl.obolibrary.org/obo/CLO_0053704 denotes IL-8
T559 45552-45570 http://purl.obolibrary.org/obo/UBERON_0002012 denotes pulmonary arterial
T560 45552-45570 http://www.ebi.ac.uk/efo/EFO_0001399 denotes pulmonary arterial
T561 45616-45620 http://www.ebi.ac.uk/efo/EFO_0001410 denotes arms
T562 45663-45667 http://purl.obolibrary.org/obo/PR_000001379 denotes IL-2
T563 45681-45685 http://purl.obolibrary.org/obo/CLO_0053704 denotes IL-8
T564 45771-45772 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T565 45800-45810 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T566 45966-45967 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T567 46359-46381 http://purl.obolibrary.org/obo/UBERON_0005409 denotes gastrointestinal tract
T568 46801-46811 http://purl.obolibrary.org/obo/UBERON_0000160 denotes intestinal
T569 46801-46811 http://www.ebi.ac.uk/efo/EFO_0000834 denotes intestinal
T570 47140-47142 http://purl.obolibrary.org/obo/CLO_0001627 denotes AA
T571 47280-47281 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T572 47383-47385 http://purl.obolibrary.org/obo/CLO_0001627 denotes AA
T573 47486-47494 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T574 47515-47525 http://purl.obolibrary.org/obo/UBERON_0000160 denotes intestinal
T575 47515-47525 http://www.ebi.ac.uk/efo/EFO_0000834 denotes intestinal
T576 47558-47563 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T577 47558-47563 http://www.ebi.ac.uk/efo/EFO_0000296 denotes blood
T578 47628-47630 http://purl.obolibrary.org/obo/CLO_0001627 denotes AA
T579 47729-47731 http://purl.obolibrary.org/obo/CLO_0001627 denotes AA
T580 47745-47747 http://purl.obolibrary.org/obo/CLO_0001627 denotes AA
T581 47764-47769 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T582 47810-47812 http://purl.obolibrary.org/obo/CLO_0001627 denotes AA
T583 47882-47884 http://purl.obolibrary.org/obo/CLO_0001627 denotes AA
T584 47893-47894 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T585 47937-47944 http://purl.obolibrary.org/obo/PR_000009054 denotes insulin
T586 47984-47989 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T587 48005-48006 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T588 48051-48059 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T589 48149-48155 http://purl.obolibrary.org/obo/UBERON_0001969 denotes Plasma
T590 48203-48204 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T591 48221-48231 http://purl.obolibrary.org/obo/UBERON_0000160 denotes intestinal
T592 48221-48231 http://www.ebi.ac.uk/efo/EFO_0000834 denotes intestinal
T593 48391-48396 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T594 48391-48396 http://www.ebi.ac.uk/efo/EFO_0000296 denotes blood
T595 48486-48492 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T596 48566-48568 http://purl.obolibrary.org/obo/CLO_0001627 denotes AA
T597 48675-48685 http://purl.obolibrary.org/obo/CLO_0001658 denotes activities
T598 48715-48727 http://purl.obolibrary.org/obo/UBERON_0001969 denotes blood plasma
T599 48795-48812 http://purl.obolibrary.org/obo/CL_0000115 denotes endothelial cells
T600 48844-48861 http://purl.obolibrary.org/obo/CL_0000115 denotes endothelial cells
T601 48914-48920 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T602 48957-48958 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T603 49097-49107 http://purl.obolibrary.org/obo/CL_0000000 denotes cell types
T604 49118-49124 http://purl.obolibrary.org/obo/UBERON_0001969 denotes Plasma
T605 49183-49187 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T606 49204-49209 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T607 49226-49232 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T608 49251-49256 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T609 49258-49275 http://purl.obolibrary.org/obo/CL_0000115 denotes endothelial cells
T610 49289-49303 http://purl.obolibrary.org/obo/CL_0000746 denotes cardiomyocytes
T611 49529-49539 http://purl.obolibrary.org/obo/CLO_0001658 denotes activities
T612 49567-49582 http://purl.obolibrary.org/obo/CL_0000786 denotes plasma to cells
T613 49671-49676 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T614 49671-49676 http://www.ebi.ac.uk/efo/EFO_0000296 denotes blood
T615 49699-49709 http://purl.obolibrary.org/obo/SO_0000418 denotes signalling
T616 49715-49716 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T617 49915-49918 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T618 49952-49972 http://purl.obolibrary.org/obo/PR_000036193 denotes amyloid beta-peptide
T619 50113-50116 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T620 50303-50304 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T621 50416-50422 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T622 50637-50640 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T623 50675-50679 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T624 50697-50703 http://purl.obolibrary.org/obo/UBERON_0000473 denotes tested
T625 50735-50738 http://purl.obolibrary.org/obo/CLO_0054060 denotes 102
T626 50754-50760 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T627 50777-50778 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T628 50955-50956 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T629 51234-51237 http://purl.obolibrary.org/obo/CLO_0050884 denotes ten
T630 51314-51315 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T631 51417-51423 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T632 51461-51471 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T633 51606-51612 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T634 51647-51648 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T635 51706-51727 http://purl.obolibrary.org/obo/PR_000036193 denotes amyloid beta-peptides
T636 51790-51793 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T637 51884-51892 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T638 51916-51919 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T639 51930-51931 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T640 52084-52090 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T641 52154-52160 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T642 52227-52237 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T643 52296-52302 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T644 52365-52371 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T645 52716-52717 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T646 52893-52894 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T647 52948-52949 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T648 52974-52980 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T649 53046-53051 http://purl.obolibrary.org/obo/UBERON_0002107 denotes liver
T650 53046-53051 http://www.ebi.ac.uk/efo/EFO_0000887 denotes liver
T651 53229-53245 http://purl.obolibrary.org/obo/CL_0000115 denotes endothelial cell
T652 53301-53319 http://purl.obolibrary.org/obo/UBERON_0002012 denotes pulmonary arteries
T653 53301-53319 http://www.ebi.ac.uk/efo/EFO_0001399 denotes pulmonary arteries
T654 53577-53581 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T655 53577-53581 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T656 53632-53636 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T657 53632-53636 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T658 53646-53651 http://purl.obolibrary.org/obo/UBERON_0000473 denotes tests
T659 53924-53932 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T660 53958-53966 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T661 54133-54134 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T662 54147-54154 http://purl.obolibrary.org/obo/CLO_0001927 denotes bending
T663 54171-54179 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T664 54231-54239 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T665 54355-54356 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T666 54523-54524 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T667 54540-54548 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T668 54647-54655 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T669 54734-54739 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T670 54852-54857 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T671 54879-54883 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T672 54895-54896 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T673 55074-55080 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T674 55081-55089 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T675 55157-55165 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T676 55327-55335 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T677 55399-55407 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T678 55669-55672 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T679 55830-55831 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T680 55853-55858 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T681 55906-55911 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T682 55943-55944 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T683 56017-56018 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T684 56027-56028 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T685 56063-56064 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T686 56124-56127 http://purl.obolibrary.org/obo/CLO_0053001 denotes 114
T687 56130-56137 http://purl.obolibrary.org/obo/UBERON_0000473 denotes Testing
T688 56196-56197 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T689 56248-56253 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T690 56255-56257 http://purl.obolibrary.org/obo/CLO_0008812 denotes rh
T691 56272-56282 http://purl.obolibrary.org/obo/CLO_0001658 denotes activities
T692 56310-56313 http://purl.obolibrary.org/obo/CLO_0053001 denotes 114
T693 56327-56328 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T694 56438-56439 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T695 56591-56592 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T696 56661-56664 http://purl.obolibrary.org/obo/CLO_0053001 denotes 114
T697 56706-56707 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T698 56740-56748 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T699 56770-56778 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T700 56861-56862 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T701 56924-56925 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T702 56973-56990 http://purl.obolibrary.org/obo/CL_0000842 denotes mononuclear cells
T703 57028-57031 http://purl.obolibrary.org/obo/CLO_0053001 denotes 114
T704 57034-57035 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T705 57125-57126 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T706 57128-57131 http://purl.obolibrary.org/obo/CLO_0053001 denotes 114
T707 57173-57181 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T708 57365-57366 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T709 57418-57426 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T710 57436-57437 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T711 57581-57589 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T712 57819-57823 http://purl.obolibrary.org/obo/CLO_0050171 denotes M–10
T713 57913-57914 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T714 57982-57983 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T715 58110-58118 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T716 58146-58154 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T717 58166-58174 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T718 58224-58232 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T719 58273-58278 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T720 58279-58285 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T721 58343-58346 http://purl.obolibrary.org/obo/CLO_0001046 denotes 116
T722 58457-58462 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T723 58668-58676 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T724 58705-58706 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T725 58807-58812 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T726 58807-58812 http://www.ebi.ac.uk/efo/EFO_0000296 denotes blood
T727 58920-58923 http://purl.obolibrary.org/obo/CLO_0053799 denotes 4-5
T728 58947-58952 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T729 58947-58952 http://www.ebi.ac.uk/efo/EFO_0000296 denotes blood
T730 59042-59046 http://purl.obolibrary.org/obo/UBERON_0003101 denotes male
T731 59042-59046 http://www.ebi.ac.uk/efo/EFO_0000970 denotes male
T732 59054-59056 http://purl.obolibrary.org/obo/CLO_0050509 denotes 27
T733 59188-59196 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T734 59306-59311 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T735 59306-59311 http://www.ebi.ac.uk/efo/EFO_0000296 denotes blood
T736 59403-59406 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T737 59472-59473 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T738 59503-59504 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T739 59699-59700 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T740 59745-59746 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T741 59833-59834 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T742 59844-59851 http://purl.obolibrary.org/obo/PR_000018263 denotes peptide
T743 59882-59883 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T744 60059-60060 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T745 60151-60152 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T746 60153-60158 http://purl.obolibrary.org/obo/CLO_0007836 denotes mouse
T747 60186-60190 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T748 60186-60190 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T749 60205-60208 http://purl.obolibrary.org/obo/CLO_0001053 denotes 121
T750 60304-60309 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T751 60460-60467 http://purl.obolibrary.org/obo/NCBITaxon_33208 denotes animals
T752 60551-60556 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T753 60637-60638 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T754 60702-60706 http://purl.obolibrary.org/obo/UBERON_0003101 denotes male
T755 60702-60706 http://www.ebi.ac.uk/efo/EFO_0000970 denotes male
T756 60767-60770 http://purl.obolibrary.org/obo/CLO_0002096 denotes C16
T757 60824-60825 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T758 60926-60934 http://purl.obolibrary.org/obo/UBERON_0001637 denotes arterial
T759 60926-60934 http://www.ebi.ac.uk/efo/EFO_0000814 denotes arterial
T760 61051-61053 http://purl.obolibrary.org/obo/CLO_0001407 denotes 52
T761 61067-61068 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T762 61296-61304 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T763 61322-61327 http://purl.obolibrary.org/obo/UBERON_0000948 denotes heart
T764 61322-61327 http://purl.obolibrary.org/obo/UBERON_0007100 denotes heart
T765 61322-61327 http://purl.obolibrary.org/obo/UBERON_0015228 denotes heart
T766 61322-61327 http://www.ebi.ac.uk/efo/EFO_0000815 denotes heart
T767 61329-61333 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T768 61329-61333 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T769 61335-61340 http://purl.obolibrary.org/obo/UBERON_0002107 denotes liver
T770 61335-61340 http://www.ebi.ac.uk/efo/EFO_0000887 denotes liver
T771 61342-61347 http://purl.obolibrary.org/obo/UBERON_0001155 denotes colon
T772 61365-61371 http://purl.obolibrary.org/obo/UBERON_0003103 denotes organs
T773 61396-61401 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T774 61396-61401 http://www.ebi.ac.uk/efo/EFO_0000296 denotes blood
T775 61406-61423 http://purl.obolibrary.org/obo/CL_0000115 denotes endothelial cells
T776 61509-61517 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T777 61521-61522 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T778 61523-61528 http://purl.obolibrary.org/obo/CLO_0007836 denotes mouse
T779 61947-61948 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T780 61966-61969 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T781 62008-62016 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T782 62061-62064 http://purl.obolibrary.org/obo/CLO_0054060 denotes 102
T783 62144-62150 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T784 62286-62292 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T785 62321-62322 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T786 62362-62368 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T787 62477-62486 http://purl.obolibrary.org/obo/OBI_0100026 denotes organisms
T788 62477-62486 http://purl.obolibrary.org/obo/UBERON_0000468 denotes organisms
T789 62830-62840 http://purl.obolibrary.org/obo/CLO_0001658 denotes activities
T790 62865-62868 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T791 62935-62938 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T792 63063-63066 http://purl.obolibrary.org/obo/CLO_0054060 denotes 102
T793 63122-63123 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T794 63326-63331 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T795 63326-63331 http://www.ebi.ac.uk/efo/EFO_0000296 denotes blood
T796 63344-63345 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T797 63636-63641 http://purl.obolibrary.org/obo/GO_0005623 denotes Cells
T798 63768-63774 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T799 63831-63841 http://purl.obolibrary.org/obo/CLO_0001658 denotes activities
T800 64091-64096 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T801 64184-64190 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T802 64191-64199 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T803 64291-64296 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T804 64526-64529 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T805 64619-64628 http://purl.obolibrary.org/obo/GO_0005764 denotes lysosomes
T806 64865-64868 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T807 64907-64915 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T808 64939-64949 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T809 64987-64997 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T810 65035-65053 http://purl.obolibrary.org/obo/GO_0030141 denotes secretory granules
T811 65054-65057 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T812 65105-65113 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T813 65290-65291 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T814 65547-65551 http://www.ebi.ac.uk/efo/EFO_0001410 denotes arms
T815 65580-65581 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T816 65687-65688 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T817 66088-66091 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T818 66136-66142 http://purl.obolibrary.org/obo/UBERON_0001637 denotes artery
T819 66136-66142 http://www.ebi.ac.uk/efo/EFO_0000814 denotes artery
T820 66253-66254 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T821 66357-66362 http://purl.obolibrary.org/obo/UBERON_0000473 denotes tests
T822 66609-66610 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T823 66661-66664 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T33721 66682-66688 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T825 66698-66701 http://purl.obolibrary.org/obo/CLO_0001046 denotes 116
T826 66740-66741 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T827 66776-66777 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T828 66837-66843 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T829 66851-66854 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T830 66879-66880 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T831 66887-66889 http://purl.obolibrary.org/obo/CLO_0001627 denotes AA
T832 66893-66894 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T833 66907-66914 http://purl.obolibrary.org/obo/PR_000018263 denotes peptide
T834 66953-66956 http://purl.obolibrary.org/obo/CLO_0001046 denotes 116
T835 66989-66991 http://purl.obolibrary.org/obo/CLO_0001627 denotes AA
T836 67097-67098 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T837 67105-67107 http://purl.obolibrary.org/obo/CLO_0001627 denotes AA
T838 67111-67112 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T839 67125-67132 http://purl.obolibrary.org/obo/PR_000018263 denotes peptide
T840 67243-67251 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T841 67475-67476 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T842 67677-67680 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T843 67681-67682 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T844 67764-67765 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T845 67820-67828 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T846 67863-67871 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T847 67953-67956 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T848 67998-67999 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T849 68045-68046 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T850 68148-68156 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T851 68284-68287 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T852 68417-68420 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T853 68534-68542 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T854 68577-68580 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T855 68581-68582 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T856 68593-68599 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T857 68674-68677 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T858 68799-68800 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T859 68952-68962 http://purl.obolibrary.org/obo/UBERON_0000160 denotes intestinal
T860 68952-68962 http://www.ebi.ac.uk/efo/EFO_0000834 denotes intestinal
T861 69105-69106 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T862 69204-69207 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T863 69234-69242 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T864 69389-69390 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T865 69541-69549 http://purl.obolibrary.org/obo/UBERON_0002553 denotes cavities
T866 69590-69591 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T867 69720-69723 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T868 69762-69767 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T869 69839-69842 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T870 69935-69940 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T871 70283-70284 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T872 70308-70309 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T873 70330-70335 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T874 70341-70344 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T875 70460-70466 http://purl.obolibrary.org/obo/CLO_0001658 denotes active
T876 70568-70569 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T877 70617-70620 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T878 70777-70781 http://purl.obolibrary.org/obo/CLO_0001185 denotes 2018
T879 70912-70920 http://purl.obolibrary.org/obo/CLO_0001658 denotes Activity
T880 71092-71096 http://purl.obolibrary.org/obo/UBERON_0003101 denotes male
T881 71092-71096 http://www.ebi.ac.uk/efo/EFO_0000970 denotes male
T882 71376-71378 http://purl.obolibrary.org/obo/CLO_0053794 denotes 41
T883 71498-71500 http://purl.obolibrary.org/obo/CLO_0053733 denotes 11
T884 71567-71575 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T885 71579-71585 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T886 71645-71646 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T887 71675-71676 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T888 71764-71768 http://purl.obolibrary.org/obo/UBERON_0003101 denotes male
T889 71764-71768 http://www.ebi.ac.uk/efo/EFO_0000970 denotes male
T890 71846-71854 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T891 71987-71995 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T892 72218-72219 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T893 72301-72309 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T894 72540-72548 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T895 72664-72672 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T896 72725-72731 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T897 72974-72984 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T898 73057-73063 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes humans
T899 73282-73290 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T900 73318-73323 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T901 73324-73340 http://purl.obolibrary.org/obo/UBERON_0002012 denotes pulmonary artery
T902 73324-73340 http://www.ebi.ac.uk/efo/EFO_0001399 denotes pulmonary artery
T903 73341-73360 http://purl.obolibrary.org/obo/CL_0000192 denotes smooth muscle cells
T904 73555-73556 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T905 73585-73593 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T906 73682-73690 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T907 74029-74030 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T908 74240-74241 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T909 74819-74820 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T910 75176-75180 http://purl.obolibrary.org/obo/UBERON_0001456 denotes face
T911 75223-75224 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T912 75455-75456 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T913 75617-75624 http://purl.obolibrary.org/obo/PR_000009054 denotes insulin
T914 75697-75705 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T915 75817-75823 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T916 75851-75857 http://purl.obolibrary.org/obo/CLO_0001658 denotes active
T917 76194-76200 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T918 76218-76224 http://purl.obolibrary.org/obo/UBERON_0001005 denotes airway
T919 76225-76230 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T920 76463-76468 http://purl.obolibrary.org/obo/UBERON_0000948 denotes heart
T921 76463-76468 http://purl.obolibrary.org/obo/UBERON_0007100 denotes heart
T922 76463-76468 http://purl.obolibrary.org/obo/UBERON_0015228 denotes heart
T923 76463-76468 http://www.ebi.ac.uk/efo/EFO_0000815 denotes heart
T924 76517-76518 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T925 76560-76566 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T926 76572-76580 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T927 76661-76665 http://purl.obolibrary.org/obo/UBERON_0003101 denotes male
T928 76661-76665 http://www.ebi.ac.uk/efo/EFO_0000970 denotes male
T929 76757-76758 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T930 76803-76811 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T931 76927-76928 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T932 77031-77039 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T933 77430-77439 http://www.ebi.ac.uk/efo/EFO_0000876 denotes extremely
T934 77626-77628 http://purl.obolibrary.org/obo/CLO_0053733 denotes 11
T935 77664-77665 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T936 77727-77733 http://purl.obolibrary.org/obo/UBERON_0002113 denotes kidney
T937 77727-77733 http://www.ebi.ac.uk/efo/EFO_0000927 denotes kidney
T938 77727-77733 http://www.ebi.ac.uk/efo/EFO_0000929 denotes kidney
T939 77759-77760 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T940 77806-77807 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T941 77849-77857 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T942 77971-77976 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T943 77971-77976 http://www.ebi.ac.uk/efo/EFO_0000296 denotes blood
T944 78019-78025 http://purl.obolibrary.org/obo/UBERON_0002113 denotes kidney
T945 78019-78025 http://www.ebi.ac.uk/efo/EFO_0000927 denotes kidney
T946 78019-78025 http://www.ebi.ac.uk/efo/EFO_0000929 denotes kidney
T947 78115-78123 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T948 78193-78194 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T949 78520-78521 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T950 78600-78605 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T951 78600-78605 http://www.ebi.ac.uk/efo/EFO_0000296 denotes blood
T952 78693-78697 http://www.ebi.ac.uk/efo/EFO_0001410 denotes arms
T953 78736-78744 http://purl.obolibrary.org/obo/OBI_0100026 denotes organism
T954 78736-78744 http://purl.obolibrary.org/obo/UBERON_0000468 denotes organism
T955 78951-78956 http://purl.obolibrary.org/obo/UBERON_0003103 denotes organ
T956 78971-78975 http://purl.obolibrary.org/obo/OGG_0000000002 denotes gene
T957 79105-79109 http://purl.obolibrary.org/obo/OGG_0000000002 denotes gene
T958 79327-79336 http://purl.obolibrary.org/obo/UBERON_0007651 denotes junctions
T959 79497-79501 http://purl.obolibrary.org/obo/OGG_0000000002 denotes gene
T960 79537-79540 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T961 79607-79608 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T962 79727-79730 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T963 79785-79786 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T964 79864-79870 http://purl.obolibrary.org/obo/UBERON_0001005 denotes airway
T965 80178-80181 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T966 80212-80216 http://www.ebi.ac.uk/efo/EFO_0001410 denotes arms
T967 80336-80342 http://purl.obolibrary.org/obo/UBERON_0001005 denotes airway
T968 80424-80429 http://purl.obolibrary.org/obo/UBERON_0003101 denotes males
T969 80424-80429 http://www.ebi.ac.uk/efo/EFO_0000970 denotes males
T970 80438-80445 http://purl.obolibrary.org/obo/UBERON_0003100 denotes females
T971 80492-80499 http://purl.obolibrary.org/obo/UBERON_0001005 denotes airways
T972 80510-80516 http://purl.obolibrary.org/obo/UBERON_0001005 denotes airway
T973 80568-80575 http://purl.obolibrary.org/obo/UBERON_0001005 denotes airways
T974 80579-80586 http://purl.obolibrary.org/obo/UBERON_0003100 denotes females
T975 80645-80650 http://purl.obolibrary.org/obo/UBERON_0003101 denotes males
T976 80645-80650 http://www.ebi.ac.uk/efo/EFO_0000970 denotes males
T977 80965-80975 http://purl.obolibrary.org/obo/CLO_0001658 denotes activities
T978 81009-81019 http://purl.obolibrary.org/obo/CLO_0001658 denotes activities
T979 81060-81065 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T980 81060-81065 http://www.ebi.ac.uk/efo/EFO_0000296 denotes blood
T981 81169-81170 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T982 81317-81322 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T983 81385-81391 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes humans
T984 81554-81555 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T985 81578-81588 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T986 81654-81655 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T987 81710-81713 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T988 82009-82014 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T989 82126-82133 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T990 82269-82278 http://purl.obolibrary.org/obo/OBI_0100026 denotes organisms
T991 82269-82278 http://purl.obolibrary.org/obo/UBERON_0000468 denotes organisms
T992 82329-82337 http://purl.obolibrary.org/obo/CLO_0001658 denotes Activity
T993 82372-82373 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T994 82548-82554 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T995 82641-82644 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T996 82662-82663 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T997 82772-82775 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T998 83017-83025 http://purl.obolibrary.org/obo/NCBITaxon_9443 denotes primates
T999 83058-83059 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T1000 83108-83115 http://purl.obolibrary.org/obo/NCBITaxon_33208 denotes animals
T1001 83171-83172 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T1002 83194-83198 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T1003 83194-83198 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T1004 83278-83279 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T1005 83445-83453 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T1006 83607-83608 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T1007 83763-83768 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T1008 83778-83781 http://purl.obolibrary.org/obo/PR_000001004 denotes CD4
T1009 83782-83789 http://purl.obolibrary.org/obo/CL_0000084 denotes T cells
T1010 84208-84218 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T1011 84489-84490 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T1012 84676-84681 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T1013 84697-84702 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T1014 84717-84722 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T1015 84758-84768 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T1016 84777-84781 http://www.ebi.ac.uk/efo/EFO_0001410 denotes arms
T1017 84862-84867 http://purl.obolibrary.org/obo/UBERON_0003103 denotes organ
T1018 84956-84966 http://purl.obolibrary.org/obo/CLO_0001658 denotes activities
T1019 85228-85233 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T1020 85228-85233 http://www.ebi.ac.uk/efo/EFO_0000296 denotes blood
T1021 85297-85302 http://purl.obolibrary.org/obo/UBERON_0003103 denotes Organ
T1022 85375-85377 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T1023 85512-85514 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T1024 85707-85715 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T1025 85774-85779 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T1026 85774-85779 http://www.ebi.ac.uk/efo/EFO_0000296 denotes blood
T1027 85878-85886 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T1028 85950-85956 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T1029 86037-86043 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T1030 86045-86048 http://purl.obolibrary.org/obo/CLO_0001046 denotes 116
T1031 86114-86122 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T1032 86211-86212 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T1033 86240-86248 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T1034 86282-86283 http://purl.obolibrary.org/obo/CLO_0001021 denotes b
T1035 86455-86460 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T1036 86455-86460 http://www.ebi.ac.uk/efo/EFO_0000296 denotes blood
T1037 86617-86622 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T1038 86630-86636 http://purl.obolibrary.org/obo/UBERON_0003103 denotes organs
T1039 86856-86864 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T1040 86872-86878 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T1041 86893-86894 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T1042 86939-86944 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T1043 86991-86999 http://purl.obolibrary.org/obo/PR_000018263 denotes peptides
T1044 87003-87009 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T1045 87069-87077 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T1046 87081-87087 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T1047 87101-87102 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T1048 87145-87146 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T1049 87179-87180 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T1050 87370-87378 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T1051 87431-87434 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T1052 87454-87460 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T1053 87603-87605 http://purl.obolibrary.org/obo/CLO_0008426 denotes pg
T1054 87620-87622 http://purl.obolibrary.org/obo/CLO_0008426 denotes pg
T1055 87683-87687 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T1056 87683-87687 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T1057 87724-87727 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T1058 87728-87734 http://purl.obolibrary.org/obo/UBERON_0000473 denotes tested
T1059 87956-87964 http://purl.obolibrary.org/obo/PR_000018263 denotes peptides
T1060 87968-87974 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T1061 88015-88016 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T1062 88045-88063 http://purl.obolibrary.org/obo/UBERON_0002012 denotes pulmonary arterial
T1063 88045-88063 http://www.ebi.ac.uk/efo/EFO_0001399 denotes pulmonary arterial
T1064 88275-88279 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T1065 88275-88279 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T1066 88449-88454 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T1067 88487-88492 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T1068 88503-88508 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T1069 88583-88589 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes humans
T1070 88626-88627 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T1071 88650-88656 http://purl.obolibrary.org/obo/NCBITaxon_33208 denotes animal
T1072 88691-88695 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T1073 88691-88695 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T1074 88722-88730 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T1075 88789-88792 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T1076 88859-88864 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T1077 88968-88974 http://purl.obolibrary.org/obo/UBERON_0000473 denotes tested
T1078 89276-89282 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T1079 89422-89424 http://purl.obolibrary.org/obo/CLO_0008426 denotes pg
T1080 89481-89483 http://purl.obolibrary.org/obo/CLO_0008426 denotes pg
T1081 89505-89506 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T1082 89532-89540 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T1083 89669-89671 http://purl.obolibrary.org/obo/CLO_0001000 denotes 35
T1084 89675-89677 http://purl.obolibrary.org/obo/CLO_0008426 denotes pg
T1085 89784-89790 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T1086 89817-89825 http://purl.obolibrary.org/obo/PR_000018263 denotes peptides
T1087 90005-90012 http://purl.obolibrary.org/obo/PR_000018263 denotes peptide
T1088 90043-90050 http://purl.obolibrary.org/obo/PR_000018263 denotes peptide
T1089 90110-90115 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T1090 90110-90115 http://www.ebi.ac.uk/efo/EFO_0000296 denotes blood
T1091 90129-90130 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T1092 90187-90193 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T1093 90312-90320 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T1094 90328-90334 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T1095 90352-90359 http://purl.obolibrary.org/obo/PR_000018263 denotes peptide
T1096 90447-90455 http://purl.obolibrary.org/obo/PR_000018263 denotes peptides
T1097 90556-90564 http://purl.obolibrary.org/obo/PR_000018263 denotes peptides
T1098 90627-90629 http://purl.obolibrary.org/obo/CLO_0008426 denotes pg
T1099 90630-90635 http://purl.obolibrary.org/obo/CLO_0007735 denotes mL, 1
T1100 90639-90641 http://purl.obolibrary.org/obo/CLO_0008426 denotes pg
T1101 90642-90648 http://purl.obolibrary.org/obo/CLO_0007736 denotes mL, <2
T1102 90649-90651 http://purl.obolibrary.org/obo/CLO_0008426 denotes pg
T1103 90659-90661 http://purl.obolibrary.org/obo/CLO_0008426 denotes pg
T1104 90673-90675 http://purl.obolibrary.org/obo/CLO_0008426 denotes pg
T1105 90761-90769 http://purl.obolibrary.org/obo/PR_000018263 denotes peptides
T1106 90775-90777 http://purl.obolibrary.org/obo/CLO_0001000 denotes 35
T1107 90781-90783 http://purl.obolibrary.org/obo/CLO_0008426 denotes pg
T1108 90796-90798 http://purl.obolibrary.org/obo/CLO_0008426 denotes pg
T1109 90799-90806 http://purl.obolibrary.org/obo/CLO_0007736 denotes mL, < 2
T1110 90807-90809 http://purl.obolibrary.org/obo/CLO_0008426 denotes pg
T1111 90818-90820 http://purl.obolibrary.org/obo/CLO_0008426 denotes pg
T1112 90832-90834 http://purl.obolibrary.org/obo/CLO_0008426 denotes pg
T1113 90914-90922 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T1114 90946-90953 http://purl.obolibrary.org/obo/PR_000018263 denotes peptide
T1115 91064-91069 http://purl.obolibrary.org/obo/UBERON_0003101 denotes males
T1116 91064-91069 http://www.ebi.ac.uk/efo/EFO_0000970 denotes males
T1117 91109-91111 http://purl.obolibrary.org/obo/CLO_0008426 denotes pg
T1118 91123-91125 http://purl.obolibrary.org/obo/CLO_0008426 denotes pg
T1119 91511-91519 http://purl.obolibrary.org/obo/PR_000018263 denotes peptides
T1120 91754-91756 http://purl.obolibrary.org/obo/CLO_0008426 denotes pg
T1121 91788-91790 http://purl.obolibrary.org/obo/CLO_0008426 denotes pg
T1122 91812-91813 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T1123 91954-91956 http://purl.obolibrary.org/obo/CLO_0008426 denotes pg
T1124 92074-92081 http://purl.obolibrary.org/obo/PR_000018263 denotes peptide
T1125 92328-92330 http://purl.obolibrary.org/obo/CLO_0008426 denotes pg
T1126 92380-92382 http://purl.obolibrary.org/obo/CLO_0008426 denotes pg
T1127 92568-92576 http://purl.obolibrary.org/obo/PR_000018263 denotes peptides
T1128 92693-92695 http://purl.obolibrary.org/obo/CLO_0008426 denotes pg
T1129 92807-92815 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T1130 92838-92844 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T1131 93250-93256 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T1132 93270-93275 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T1133 93375-93377 http://purl.obolibrary.org/obo/CLO_0008426 denotes pg
T1134 93424-93432 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T1135 93443-93449 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T1136 93551-93552 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T1137 93584-93592 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T1138 93954-93956 http://purl.obolibrary.org/obo/CLO_0008426 denotes pg
T1139 94001-94009 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T1140 94073-94083 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T1141 94093-94097 http://www.ebi.ac.uk/efo/EFO_0001410 denotes arms
T1142 94135-94145 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T1143 94213-94219 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T1144 94234-94235 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T1145 94432-94440 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T1146 94471-94481 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T1147 94490-94494 http://www.ebi.ac.uk/efo/EFO_0001410 denotes arms
T1148 94570-94575 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T1149 94585-94591 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T1150 94765-94773 http://purl.obolibrary.org/obo/PR_000018263 denotes peptides
T1151 94816-94824 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T1152 94848-94856 http://purl.obolibrary.org/obo/UBERON_0001637 denotes arterial
T1153 94848-94856 http://www.ebi.ac.uk/efo/EFO_0000814 denotes arterial
T1154 95037-95039 http://purl.obolibrary.org/obo/CLO_0054055 denotes 71
T1155 95072-95073 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T1156 95231-95232 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T1157 95283-95291 http://purl.obolibrary.org/obo/PR_000018263 denotes peptides
T1158 95308-95314 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T1159 95347-95353 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T1160 95423-95429 http://purl.obolibrary.org/obo/UBERON_0001637 denotes artery
T1161 95423-95429 http://www.ebi.ac.uk/efo/EFO_0000814 denotes artery
T1162 95463-95464 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T1163 95528-95529 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T1164 95607-95612 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T1165 95607-95612 http://www.ebi.ac.uk/efo/EFO_0000296 denotes blood
T1166 95712-95719 http://purl.obolibrary.org/obo/PR_000018263 denotes peptide
T1167 95811-95817 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T1168 95838-95845 http://purl.obolibrary.org/obo/PR_000018263 denotes peptide
T1169 96077-96078 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T1170 96163-96169 http://purl.obolibrary.org/obo/CLO_0001658 denotes active
T1171 96179-96181 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T1172 96714-96719 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T1173 96738-96746 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T1174 96775-96780 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T1175 96786-96792 http://purl.obolibrary.org/obo/SO_0000418 denotes signal
T1176 96816-96817 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T41156 96903-96908 http://purl.obolibrary.org/obo/CLO_0007836 denotes mouse
T1178 96935-96940 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T1179 96945-96950 http://purl.obolibrary.org/obo/CLO_0007836 denotes mouse
T1180 96956-96964 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T1181 96971-96976 http://purl.obolibrary.org/obo/CLO_0007836 denotes mouse
T1182 97006-97011 http://purl.obolibrary.org/obo/CLO_0007836 denotes mouse
T1183 97066-97071 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T1184 97088-97091 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T1185 97142-97147 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T1186 97184-97187 http://purl.obolibrary.org/obo/CLO_0002096 denotes C16
T1187 97245-97249 http://purl.obolibrary.org/obo/UBERON_0001456 denotes face
T1188 97307-97309 http://purl.obolibrary.org/obo/CLO_0050475 denotes my
T1189 97340-97343 http://purl.obolibrary.org/obo/CLO_0002096 denotes C16
T1190 97392-97395 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T1191 97401-97407 http://purl.obolibrary.org/obo/UBERON_0000473 denotes tested
T1192 97419-97425 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes humans
T1193 97429-97430 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T1194 97553-97560 http://purl.obolibrary.org/obo/CLO_0009985 denotes focused
T1195 97561-97563 http://purl.obolibrary.org/obo/CLO_0050475 denotes my
T1196 97591-97596 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T1197 97696-97701 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T1198 97780-97781 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T1199 98244-98247 http://purl.obolibrary.org/obo/CLO_0002096 denotes C16
T1200 98308-98311 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T1201 98354-98362 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T1202 98446-98451 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lungs
T1203 98479-98484 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T1204 98490-98498 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T1205 98662-98670 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T1206 98725-98727 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T1207 98864-98874 http://purl.obolibrary.org/obo/CLO_0001658 denotes activators
T1208 98899-98909 http://purl.obolibrary.org/obo/CLO_0001658 denotes activating
T1209 98968-98976 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T1210 99039-99040 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T1211 99067-99073 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes humans
T1212 99219-99225 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes humans
T1213 99242-99243 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T1214 99287-99291 http://purl.obolibrary.org/obo/CLO_0002096 denotes C-16
T1215 99326-99336 http://purl.obolibrary.org/obo/CLO_0001658 denotes activating
T1216 99400-99401 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T1217 99441-99442 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T1218 99492-99493 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T1219 99521-99522 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T1220 99530-99537 http://purl.obolibrary.org/obo/PR_000009054 denotes insulin
T1221 99579-99580 http://purl.obolibrary.org/obo/CLO_0001021 denotes b
T1222 99696-99706 http://purl.obolibrary.org/obo/CLO_0001658 denotes activating
T1223 99783-99784 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T1224 99810-99811 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T1225 99831-99832 http://purl.obolibrary.org/obo/CLO_0001020 denotes a

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T1 74-85 Chemical denotes Angiotensin http://purl.obolibrary.org/obo/CHEBI_2719
T2 199-210 Chemical denotes angiotensin http://purl.obolibrary.org/obo/CHEBI_48433
T3 219-222 Chemical denotes RAS http://purl.obolibrary.org/obo/CHEBI_63620
T4 389-392 Chemical denotes RAS http://purl.obolibrary.org/obo/CHEBI_63620
T5 393-411 Chemical denotes pathway inhibitors http://purl.obolibrary.org/obo/CHEBI_76932
T6 401-411 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T7 490-500 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T8 530-534 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T10 643-647 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T12 649-658 Chemical denotes chelators http://purl.obolibrary.org/obo/CHEBI_38161
T13 669-679 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T14 879-890 Chemical denotes angiotensin http://purl.obolibrary.org/obo/CHEBI_48433
T15 1307-1313 Chemical denotes oxygen http://purl.obolibrary.org/obo/CHEBI_25805
T16 1335-1350 Chemical denotes glucocorticoids http://purl.obolibrary.org/obo/CHEBI_24261
T17 1365-1376 Chemical denotes chloroquine http://purl.obolibrary.org/obo/CHEBI_3638
T18 1382-1392 Chemical denotes macrolides http://purl.obolibrary.org/obo/CHEBI_25106
T19 1878-1887 Chemical denotes biomarker http://purl.obolibrary.org/obo/CHEBI_59163
T20 2094-2096 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T22 2101-2103 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T24 2107-2109 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T26 2113-2115 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T28 3037-3053 Chemical denotes antihypertensive http://purl.obolibrary.org/obo/CHEBI_35674
T29 3929-3940 Chemical denotes Angiotensin http://purl.obolibrary.org/obo/CHEBI_2719
T30 4015-4022 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T31 4311-4318 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T32 4355-4362 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T33 4732-4739 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T34 4998-5005 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T35 5027-5029 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T37 5355-5362 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T38 5387-5394 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T39 5489-5496 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T40 5868-5875 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T41 6426-6437 Chemical denotes angiotensin http://purl.obolibrary.org/obo/CHEBI_48433
T42 6535-6542 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T43 6629-6636 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T44 6781-6790 Chemical denotes biomarker http://purl.obolibrary.org/obo/CHEBI_59163
T45 7610-7617 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T46 7837-7844 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T47 8027-8034 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T48 8198-8206 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T49 8294-8307 Chemical denotes glycoproteins http://purl.obolibrary.org/obo/CHEBI_17089
T50 8379-8381 Chemical denotes S2 http://purl.obolibrary.org/obo/CHEBI_29387
T51 8383-8390 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T52 8451-8459 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T53 8520-8522 Chemical denotes S2 http://purl.obolibrary.org/obo/CHEBI_29387
T54 8755-8767 Chemical denotes glycoprotein http://purl.obolibrary.org/obo/CHEBI_17089
T55 9029-9031 Chemical denotes S2 http://purl.obolibrary.org/obo/CHEBI_29387
T56 9475-9485 Chemical denotes amino acid http://purl.obolibrary.org/obo/CHEBI_33709
T57 9475-9480 Chemical denotes amino http://purl.obolibrary.org/obo/CHEBI_46882
T58 9481-9485 Chemical denotes acid http://purl.obolibrary.org/obo/CHEBI_37527
T59 9552-9559 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T60 9630-9637 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T61 9819-9827 Chemical denotes molecule http://purl.obolibrary.org/obo/CHEBI_25367
T62 9990-10000 Chemical denotes ferredoxin http://purl.obolibrary.org/obo/CHEBI_5017
T63 10199-10210 Chemical denotes amino acids http://purl.obolibrary.org/obo/CHEBI_33709
T64 10199-10204 Chemical denotes amino http://purl.obolibrary.org/obo/CHEBI_46882
T65 10205-10210 Chemical denotes acids http://purl.obolibrary.org/obo/CHEBI_37527
T66 10365-10367 Chemical denotes S2 http://purl.obolibrary.org/obo/CHEBI_29387
T67 10776-10778 Chemical denotes S2 http://purl.obolibrary.org/obo/CHEBI_29387
T68 10811-10818 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T69 11092-11099 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T70 11304-11312 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T71 13192-13200 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T72 13262-13269 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T73 13806-13813 Chemical denotes Pathway http://purl.obolibrary.org/obo/CHEBI_34922
T74 13848-13852 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T76 13924-13935 Chemical denotes angiotensin http://purl.obolibrary.org/obo/CHEBI_48433
T77 13944-13947 Chemical denotes RAS http://purl.obolibrary.org/obo/CHEBI_63620
T78 13965-13976 Chemical denotes angiotensin http://purl.obolibrary.org/obo/CHEBI_48433
T79 13978-13981 Chemical denotes Ang http://purl.obolibrary.org/obo/CHEBI_48433
T80 13989-13991 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T81 13997-14000 Chemical denotes Ang http://purl.obolibrary.org/obo/CHEBI_48433
T82 14011-14014 Chemical denotes Ang http://purl.obolibrary.org/obo/CHEBI_48433
T83 14064-14071 Chemical denotes peptide http://purl.obolibrary.org/obo/CHEBI_16670
T84 14093-14096 Chemical denotes Arg http://purl.obolibrary.org/obo/CHEBI_16467|http://purl.obolibrary.org/obo/CHEBI_29952
T86 14100-14110 Chemical denotes bradykinin http://purl.obolibrary.org/obo/CHEBI_3165
T87 14151-14154 Chemical denotes Ang http://purl.obolibrary.org/obo/CHEBI_48433
T88 14165-14168 Chemical denotes Ang http://purl.obolibrary.org/obo/CHEBI_48433
T89 14175-14183 Chemical denotes peptides http://purl.obolibrary.org/obo/CHEBI_16670
T90 14213-14216 Chemical denotes Ang http://purl.obolibrary.org/obo/CHEBI_48433
T91 14217-14219 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T92 14220-14223 Chemical denotes Ang http://purl.obolibrary.org/obo/CHEBI_48433
T93 14224-14226 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T94 14421-14433 Chemical denotes nitric oxide http://purl.obolibrary.org/obo/CHEBI_16480
T95 14428-14433 Chemical denotes oxide http://purl.obolibrary.org/obo/CHEBI_25741|http://purl.obolibrary.org/obo/CHEBI_29356
T97 14741-14744 Chemical denotes Ang http://purl.obolibrary.org/obo/CHEBI_48433
T98 14745-14747 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T99 14798-14809 Chemical denotes aldosterone http://purl.obolibrary.org/obo/CHEBI_27584|http://purl.obolibrary.org/obo/CHEBI_30834
T101 15096-15106 Chemical denotes antagonist http://purl.obolibrary.org/obo/CHEBI_48706
T102 15288-15291 Chemical denotes Ang http://purl.obolibrary.org/obo/CHEBI_48433
T103 15606-15609 Chemical denotes Ang http://purl.obolibrary.org/obo/CHEBI_48433
T104 15610-15612 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T105 15687-15690 Chemical denotes Ang http://purl.obolibrary.org/obo/CHEBI_48433
T106 15803-15806 Chemical denotes Ang http://purl.obolibrary.org/obo/CHEBI_48433
T107 16649-16652 Chemical denotes C16 http://purl.obolibrary.org/obo/CHEBI_15756
T108 16674-16688 Chemical denotes ACE2 inhibitor http://purl.obolibrary.org/obo/CHEBI_147289
T109 16679-16688 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T110 17068-17071 Chemical denotes Ang http://purl.obolibrary.org/obo/CHEBI_48433
T111 17072-17074 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T112 17351-17354 Chemical denotes Ang http://purl.obolibrary.org/obo/CHEBI_48433
T113 17505-17515 Chemical denotes antagonist http://purl.obolibrary.org/obo/CHEBI_48706
T114 17602-17605 Chemical denotes Ang http://purl.obolibrary.org/obo/CHEBI_48433
T115 17606-17608 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T116 17887-17895 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T117 18206-18213 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T118 18346-18353 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T119 18385-18392 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T120 18451-18453 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T122 18775-18778 Chemical denotes RAS http://purl.obolibrary.org/obo/CHEBI_63620
T123 18802-18809 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T124 18879-18882 Chemical denotes Ang http://purl.obolibrary.org/obo/CHEBI_48433
T125 18883-18885 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T126 19156-19159 Chemical denotes RAS http://purl.obolibrary.org/obo/CHEBI_63620
T127 19331-19334 Chemical denotes RAS http://purl.obolibrary.org/obo/CHEBI_63620
T128 19431-19434 Chemical denotes Ang http://purl.obolibrary.org/obo/CHEBI_48433
T129 19474-19477 Chemical denotes Ang http://purl.obolibrary.org/obo/CHEBI_48433
T130 19478-19480 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T131 20060-20063 Chemical denotes Ang http://purl.obolibrary.org/obo/CHEBI_48433
T132 20064-20066 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T133 20390-20393 Chemical denotes Ang http://purl.obolibrary.org/obo/CHEBI_48433
T134 20511-20514 Chemical denotes Ang http://purl.obolibrary.org/obo/CHEBI_48433
T135 20542-20545 Chemical denotes CO2 http://purl.obolibrary.org/obo/CHEBI_16526
T136 20773-20776 Chemical denotes RAS http://purl.obolibrary.org/obo/CHEBI_63620
T137 20820-20823 Chemical denotes Ang http://purl.obolibrary.org/obo/CHEBI_48433
T138 20889-20892 Chemical denotes Ang http://purl.obolibrary.org/obo/CHEBI_48433
T139 20893-20895 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T140 20897-20900 Chemical denotes Ang http://purl.obolibrary.org/obo/CHEBI_48433
T141 20908-20911 Chemical denotes Ang http://purl.obolibrary.org/obo/CHEBI_48433
T142 20941-20951 Chemical denotes metabolite http://purl.obolibrary.org/obo/CHEBI_25212
T143 20953-20956 Chemical denotes Ang http://purl.obolibrary.org/obo/CHEBI_48433
T144 20997-21000 Chemical denotes Ang http://purl.obolibrary.org/obo/CHEBI_48433
T145 21016-21019 Chemical denotes Ang http://purl.obolibrary.org/obo/CHEBI_48433
T146 21041-21044 Chemical denotes Ang http://purl.obolibrary.org/obo/CHEBI_48433
T147 21093-21119 Chemical denotes atrial natriuretic peptide http://purl.obolibrary.org/obo/CHEBI_80233
T148 21112-21119 Chemical denotes peptide http://purl.obolibrary.org/obo/CHEBI_16670
T149 21194-21197 Chemical denotes Ang http://purl.obolibrary.org/obo/CHEBI_48433
T150 21222-21229 Chemical denotes peptide http://purl.obolibrary.org/obo/CHEBI_16670
T151 21339-21342 Chemical denotes Ang http://purl.obolibrary.org/obo/CHEBI_48433
T152 21442-21445 Chemical denotes Ang http://purl.obolibrary.org/obo/CHEBI_48433
T153 21536-21538 Chemical denotes NF http://purl.obolibrary.org/obo/CHEBI_141424|http://purl.obolibrary.org/obo/CHEBI_25573|http://purl.obolibrary.org/obo/CHEBI_1224
T156 21622-21625 Chemical denotes Ang http://purl.obolibrary.org/obo/CHEBI_48433
T157 21788-21790 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T159 22076-22079 Chemical denotes Ang http://purl.obolibrary.org/obo/CHEBI_48433
T160 22482-22486 Chemical denotes acid http://purl.obolibrary.org/obo/CHEBI_37527
T161 22515-22518 Chemical denotes Ang http://purl.obolibrary.org/obo/CHEBI_48433
T162 22519-22521 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T163 22860-22863 Chemical denotes Ang http://purl.obolibrary.org/obo/CHEBI_48433
T164 22864-22866 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T165 22871-22874 Chemical denotes Ang http://purl.obolibrary.org/obo/CHEBI_48433
T166 22886-22889 Chemical denotes Ang http://purl.obolibrary.org/obo/CHEBI_48433
T167 22890-22892 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T168 23111-23114 Chemical denotes Ang http://purl.obolibrary.org/obo/CHEBI_48433
T169 23137-23140 Chemical denotes Ang http://purl.obolibrary.org/obo/CHEBI_48433
T170 23270-23273 Chemical denotes Ang http://purl.obolibrary.org/obo/CHEBI_48433
T171 23569-23572 Chemical denotes Ang http://purl.obolibrary.org/obo/CHEBI_48433
T172 23612-23614 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T174 23677-23679 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T176 23764-23766 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T178 23832-23839 Chemical denotes agonist http://purl.obolibrary.org/obo/CHEBI_48705
T179 23855-23867 Chemical denotes nitric oxide http://purl.obolibrary.org/obo/CHEBI_16480
T180 23862-23867 Chemical denotes oxide http://purl.obolibrary.org/obo/CHEBI_25741|http://purl.obolibrary.org/obo/CHEBI_29356
T182 23895-23897 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T184 24087-24089 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T186 24129-24136 Chemical denotes antigen http://purl.obolibrary.org/obo/CHEBI_59132
T187 24353-24355 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T189 24371-24374 Chemical denotes Ang http://purl.obolibrary.org/obo/CHEBI_48433
T190 24449-24451 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T192 24636-24639 Chemical denotes Ang http://purl.obolibrary.org/obo/CHEBI_48433
T193 24666-24668 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T195 24820-24823 Chemical denotes RAS http://purl.obolibrary.org/obo/CHEBI_63620
T196 25103-25106 Chemical denotes Ang http://purl.obolibrary.org/obo/CHEBI_48433
T197 25113-25116 Chemical denotes Ang http://purl.obolibrary.org/obo/CHEBI_48433
T198 25117-25119 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T199 25248-25262 Chemical denotes ACE inhibitors http://purl.obolibrary.org/obo/CHEBI_35457
T200 25252-25262 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T201 25264-25269 Chemical denotes ACEIs http://purl.obolibrary.org/obo/CHEBI_35457
T202 25277-25280 Chemical denotes Ang http://purl.obolibrary.org/obo/CHEBI_48433
T203 25281-25283 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T204 25479-25482 Chemical denotes Ang http://purl.obolibrary.org/obo/CHEBI_48433
T205 25492-25495 Chemical denotes Ang http://purl.obolibrary.org/obo/CHEBI_48433
T206 25496-25498 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T207 25584-25587 Chemical denotes Ang http://purl.obolibrary.org/obo/CHEBI_48433
T208 25588-25590 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T209 25682-25685 Chemical denotes Ang http://purl.obolibrary.org/obo/CHEBI_48433
T210 25686-25688 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T211 25865-25868 Chemical denotes Ang http://purl.obolibrary.org/obo/CHEBI_48433
T212 25889-25892 Chemical denotes Ang http://purl.obolibrary.org/obo/CHEBI_48433
T213 25893-25895 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T214 25967-25977 Chemical denotes antagonist http://purl.obolibrary.org/obo/CHEBI_48706
T215 25986-25989 Chemical denotes Ang http://purl.obolibrary.org/obo/CHEBI_48433
T216 26034-26037 Chemical denotes Ang http://purl.obolibrary.org/obo/CHEBI_48433
T217 26058-26061 Chemical denotes Ang http://purl.obolibrary.org/obo/CHEBI_48433
T218 26062-26064 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T219 26151-26154 Chemical denotes Ang http://purl.obolibrary.org/obo/CHEBI_48433
T220 26173-26178 Chemical denotes ACEIs http://purl.obolibrary.org/obo/CHEBI_35457
T221 26201-26204 Chemical denotes Ang http://purl.obolibrary.org/obo/CHEBI_48433
T222 26205-26207 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T223 26248-26251 Chemical denotes Ang http://purl.obolibrary.org/obo/CHEBI_48433
T224 26252-26259 Chemical denotes peptide http://purl.obolibrary.org/obo/CHEBI_16670
T225 26281-26284 Chemical denotes Ang http://purl.obolibrary.org/obo/CHEBI_48433
T226 26285-26287 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T227 26359-26362 Chemical denotes Ang http://purl.obolibrary.org/obo/CHEBI_48433
T228 26418-26425 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T229 26585-26588 Chemical denotes RAS http://purl.obolibrary.org/obo/CHEBI_63620
T230 26696-26699 Chemical denotes Ang http://purl.obolibrary.org/obo/CHEBI_48433
T231 26700-26702 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T232 26788-26791 Chemical denotes Ang http://purl.obolibrary.org/obo/CHEBI_48433
T233 27045-27048 Chemical denotes Ang http://purl.obolibrary.org/obo/CHEBI_48433
T234 27049-27051 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T235 27065-27075 Chemical denotes antagonist http://purl.obolibrary.org/obo/CHEBI_48706
T236 27076-27079 Chemical denotes Ang http://purl.obolibrary.org/obo/CHEBI_48433
T237 27170-27173 Chemical denotes RAS http://purl.obolibrary.org/obo/CHEBI_63620
T238 27232-27235 Chemical denotes Ang http://purl.obolibrary.org/obo/CHEBI_48433
T239 27242-27245 Chemical denotes Ang http://purl.obolibrary.org/obo/CHEBI_48433
T240 27246-27248 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T241 27371-27374 Chemical denotes Ang http://purl.obolibrary.org/obo/CHEBI_48433
T242 27653-27656 Chemical denotes RAS http://purl.obolibrary.org/obo/CHEBI_63620
T243 27908-27915 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T244 28452-28454 Chemical denotes S2 http://purl.obolibrary.org/obo/CHEBI_29387
T245 28519-28531 Chemical denotes glycoprotein http://purl.obolibrary.org/obo/CHEBI_17089
T246 28613-28615 Chemical denotes S2 http://purl.obolibrary.org/obo/CHEBI_29387
T247 28692-28694 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T249 28952-28954 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T251 29078-29080 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T253 29185-29187 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T255 29844-29851 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T256 29990-29992 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T258 30396-30407 Chemical denotes angiotensin http://purl.obolibrary.org/obo/CHEBI_48433
T259 30491-30494 Chemical denotes Ang http://purl.obolibrary.org/obo/CHEBI_48433
T260 30498-30501 Chemical denotes Ang http://purl.obolibrary.org/obo/CHEBI_48433
T261 30502-30504 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T262 30506-30509 Chemical denotes Ang http://purl.obolibrary.org/obo/CHEBI_48433
T263 30517-30520 Chemical denotes Ang http://purl.obolibrary.org/obo/CHEBI_48433
T264 30528-30531 Chemical denotes Ang http://purl.obolibrary.org/obo/CHEBI_48433
T265 30555-30565 Chemical denotes metabolite http://purl.obolibrary.org/obo/CHEBI_25212
T266 30566-30576 Chemical denotes bradykinin http://purl.obolibrary.org/obo/CHEBI_3165
T267 30721-30724 Chemical denotes Ang http://purl.obolibrary.org/obo/CHEBI_48433
T268 30725-30727 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T269 30822-30825 Chemical denotes Ang http://purl.obolibrary.org/obo/CHEBI_48433
T270 30826-30828 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T271 30862-30865 Chemical denotes Ang http://purl.obolibrary.org/obo/CHEBI_48433
T272 30888-30891 Chemical denotes Ang http://purl.obolibrary.org/obo/CHEBI_48433
T273 30964-30966 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T275 31200-31203 Chemical denotes Ang http://purl.obolibrary.org/obo/CHEBI_48433
T276 31257-31259 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T278 31368-31371 Chemical denotes Ang http://purl.obolibrary.org/obo/CHEBI_48433
T279 31469-31472 Chemical denotes Ang http://purl.obolibrary.org/obo/CHEBI_48433
T280 31473-31475 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T281 31512-31515 Chemical denotes Ang http://purl.obolibrary.org/obo/CHEBI_48433
T282 31516-31518 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T283 31586-31589 Chemical denotes Ang http://purl.obolibrary.org/obo/CHEBI_48433
T284 31751-31754 Chemical denotes RAS http://purl.obolibrary.org/obo/CHEBI_63620
T285 31822-31825 Chemical denotes Ang http://purl.obolibrary.org/obo/CHEBI_48433
T286 31838-31841 Chemical denotes Ang http://purl.obolibrary.org/obo/CHEBI_48433
T287 31842-31844 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T288 31937-31940 Chemical denotes Ang http://purl.obolibrary.org/obo/CHEBI_48433
T289 32109-32112 Chemical denotes RAS http://purl.obolibrary.org/obo/CHEBI_63620
T290 33174-33177 Chemical denotes Ang http://purl.obolibrary.org/obo/CHEBI_48433
T291 33185-33188 Chemical denotes Ang http://purl.obolibrary.org/obo/CHEBI_48433
T292 33189-33191 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T293 33196-33199 Chemical denotes Ang http://purl.obolibrary.org/obo/CHEBI_48433
T294 33206-33213 Chemical denotes peptide http://purl.obolibrary.org/obo/CHEBI_16670
T295 33318-33321 Chemical denotes Arg http://purl.obolibrary.org/obo/CHEBI_16467|http://purl.obolibrary.org/obo/CHEBI_29952
T297 33325-33335 Chemical denotes bradykinin http://purl.obolibrary.org/obo/CHEBI_3165
T298 33348-33358 Chemical denotes bradykinin http://purl.obolibrary.org/obo/CHEBI_3165
T299 33390-33398 Chemical denotes peptides http://purl.obolibrary.org/obo/CHEBI_16670
T300 33519-33522 Chemical denotes RAS http://purl.obolibrary.org/obo/CHEBI_63620
T301 33768-33771 Chemical denotes RAS http://purl.obolibrary.org/obo/CHEBI_63620
T302 33909-33912 Chemical denotes RAS http://purl.obolibrary.org/obo/CHEBI_63620
T303 34156-34162 Chemical denotes serine http://purl.obolibrary.org/obo/CHEBI_17822
T304 34236-34254 Chemical denotes protease inhibitor http://purl.obolibrary.org/obo/CHEBI_37670|http://purl.obolibrary.org/obo/CHEBI_60258
T306 34245-34254 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T307 34715-34718 Chemical denotes RAS http://purl.obolibrary.org/obo/CHEBI_63620
T308 34991-35005 Chemical denotes apolipoprotein http://purl.obolibrary.org/obo/CHEBI_39015
T309 35039-35050 Chemical denotes polypeptide http://purl.obolibrary.org/obo/CHEBI_15841
T310 35195-35198 Chemical denotes RAS http://purl.obolibrary.org/obo/CHEBI_63620
T311 35210-35220 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T312 35228-35231 Chemical denotes RAS http://purl.obolibrary.org/obo/CHEBI_63620
T313 35696-35706 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T314 35734-35737 Chemical denotes Ang http://purl.obolibrary.org/obo/CHEBI_48433
T315 35755-35758 Chemical denotes Ang http://purl.obolibrary.org/obo/CHEBI_48433
T316 35787-35798 Chemical denotes antagonists http://purl.obolibrary.org/obo/CHEBI_48706
T317 35815-35818 Chemical denotes Ang http://purl.obolibrary.org/obo/CHEBI_48433
T318 36034-36037 Chemical denotes Ang http://purl.obolibrary.org/obo/CHEBI_48433
T319 36060-36063 Chemical denotes Ang http://purl.obolibrary.org/obo/CHEBI_48433
T320 36137-36147 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T321 36154-36165 Chemical denotes antagonists http://purl.obolibrary.org/obo/CHEBI_48706
T322 36315-36320 Chemical denotes NADPH http://purl.obolibrary.org/obo/CHEBI_16474|http://purl.obolibrary.org/obo/CHEBI_57783
T324 36329-36331 Chemical denotes NF http://purl.obolibrary.org/obo/CHEBI_141424|http://purl.obolibrary.org/obo/CHEBI_25573|http://purl.obolibrary.org/obo/CHEBI_1224
T327 36372-36375 Chemical denotes Ang http://purl.obolibrary.org/obo/CHEBI_48433
T328 36376-36378 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T329 36403-36406 Chemical denotes Ang http://purl.obolibrary.org/obo/CHEBI_48433
T330 36616-36619 Chemical denotes Ang http://purl.obolibrary.org/obo/CHEBI_48433
T331 36620-36622 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T332 36734-36737 Chemical denotes Ang http://purl.obolibrary.org/obo/CHEBI_48433
T333 36738-36740 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T334 36780-36783 Chemical denotes Ang http://purl.obolibrary.org/obo/CHEBI_48433
T335 36986-36993 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T336 37067-37070 Chemical denotes Ang http://purl.obolibrary.org/obo/CHEBI_48433
T337 37071-37073 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T338 37206-37209 Chemical denotes Ang http://purl.obolibrary.org/obo/CHEBI_48433
T339 37210-37212 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T340 37251-37255 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T341 37671-37682 Chemical denotes antagonists http://purl.obolibrary.org/obo/CHEBI_48706
T342 37911-37922 Chemical denotes antagonists http://purl.obolibrary.org/obo/CHEBI_48706
T343 38025-38031 Chemical denotes Action http://purl.obolibrary.org/obo/CHEBI_5133
T344 38060-38063 Chemical denotes RAS http://purl.obolibrary.org/obo/CHEBI_63620
T345 38064-38071 Chemical denotes Pathway http://purl.obolibrary.org/obo/CHEBI_34922
T346 38186-38190 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T348 38321-38331 Chemical denotes amino acid http://purl.obolibrary.org/obo/CHEBI_33709
T349 38321-38326 Chemical denotes amino http://purl.obolibrary.org/obo/CHEBI_46882
T350 38327-38331 Chemical denotes acid http://purl.obolibrary.org/obo/CHEBI_37527
T351 38413-38422 Chemical denotes dipeptide http://purl.obolibrary.org/obo/CHEBI_46761
T352 38507-38514 Chemical denotes proline http://purl.obolibrary.org/obo/CHEBI_17203|http://purl.obolibrary.org/obo/CHEBI_26271
T354 38542-38560 Chemical denotes C-terminal residue http://purl.obolibrary.org/obo/CHEBI_33711
T355 38597-38600 Chemical denotes RAS http://purl.obolibrary.org/obo/CHEBI_63620
T356 38605-38615 Chemical denotes bradykinin http://purl.obolibrary.org/obo/CHEBI_3165
T357 38616-38624 Chemical denotes peptides http://purl.obolibrary.org/obo/CHEBI_16670
T358 38689-38697 Chemical denotes peptides http://purl.obolibrary.org/obo/CHEBI_16670
T359 38724-38733 Chemical denotes Apelin-13 http://purl.obolibrary.org/obo/CHEBI_80131
T360 38963-38965 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T361 39238-39241 Chemical denotes Ang http://purl.obolibrary.org/obo/CHEBI_48433
T362 39410-39414 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T364 39456-39460 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T366 39471-39475 Chemical denotes EDTA http://purl.obolibrary.org/obo/CHEBI_42191|http://purl.obolibrary.org/obo/CHEBI_64755
T368 39516-39524 Chemical denotes chloride http://purl.obolibrary.org/obo/CHEBI_17996
T369 39528-39536 Chemical denotes fluoride http://purl.obolibrary.org/obo/CHEBI_17051
T370 39537-39543 Chemical denotes anions http://purl.obolibrary.org/obo/CHEBI_22563
T371 39548-39559 Chemical denotes zinc cation http://purl.obolibrary.org/obo/CHEBI_29105|http://purl.obolibrary.org/obo/CHEBI_63056
T373 39548-39552 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T375 39553-39559 Chemical denotes cation http://purl.obolibrary.org/obo/CHEBI_36916
T376 39595-39603 Chemical denotes chloride http://purl.obolibrary.org/obo/CHEBI_17996
T377 39609-39613 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T379 39693-39698 Chemical denotes anion http://purl.obolibrary.org/obo/CHEBI_22563
T380 39703-39707 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T382 39784-39792 Chemical denotes chloride http://purl.obolibrary.org/obo/CHEBI_17996
T383 39793-39797 Chemical denotes ions http://purl.obolibrary.org/obo/CHEBI_24870
T384 39808-39811 Chemical denotes Ang http://purl.obolibrary.org/obo/CHEBI_48433
T385 39856-39859 Chemical denotes Ang http://purl.obolibrary.org/obo/CHEBI_48433
T386 39860-39862 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T387 39867-39870 Chemical denotes Ang http://purl.obolibrary.org/obo/CHEBI_48433
T388 39892-39895 Chemical denotes Ang http://purl.obolibrary.org/obo/CHEBI_48433
T389 39896-39898 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T390 39933-39941 Chemical denotes chloride http://purl.obolibrary.org/obo/CHEBI_17996
T391 40074-40082 Chemical denotes chloride http://purl.obolibrary.org/obo/CHEBI_17996
T392 40234-40238 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T394 40444-40448 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T396 40478-40485 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T397 40786-40790 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T399 40855-40859 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T401 40949-40953 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T403 41100-41104 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T405 41138-41142 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T407 41287-41291 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T409 41340-41344 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T411 41423-41427 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T413 41481-41485 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T415 41508-41512 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T417 41560-41564 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T419 41674-41678 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T421 41727-41731 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T423 41782-41786 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T425 41887-41891 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T427 41975-41979 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T429 42074-42078 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T431 42150-42154 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T433 42171-42175 Chemical denotes ions http://purl.obolibrary.org/obo/CHEBI_24870
T434 42184-42188 Chemical denotes iron http://purl.obolibrary.org/obo/CHEBI_18248
T435 42235-42239 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T437 42301-42305 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T439 42391-42395 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T441 42552-42555 Chemical denotes Ang http://purl.obolibrary.org/obo/CHEBI_48433
T442 42556-42563 Chemical denotes peptide http://purl.obolibrary.org/obo/CHEBI_16670
T443 42845-42848 Chemical denotes RAS http://purl.obolibrary.org/obo/CHEBI_63620
T444 43108-43112 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T446 43237-43241 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T448 43305-43309 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T450 43467-43470 Chemical denotes Zn2 http://purl.obolibrary.org/obo/CHEBI_37256
T451 43565-43568 Chemical denotes Zn2 http://purl.obolibrary.org/obo/CHEBI_37256
T452 43862-43867 Chemical denotes ZnCl2 http://purl.obolibrary.org/obo/CHEBI_49976
T453 43868-43871 Chemical denotes ZnO http://purl.obolibrary.org/obo/CHEBI_36560
T454 43872-43888 Chemical denotes hexachloroethane http://purl.obolibrary.org/obo/CHEBI_39227
T455 43966-43970 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T457 44131-44139 Chemical denotes chloride http://purl.obolibrary.org/obo/CHEBI_17996
T458 44144-44153 Chemical denotes zinc ions http://purl.obolibrary.org/obo/CHEBI_27365
T459 44144-44148 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T461 44149-44153 Chemical denotes ions http://purl.obolibrary.org/obo/CHEBI_24870
T462 44227-44230 Chemical denotes RAS http://purl.obolibrary.org/obo/CHEBI_63620
T463 44403-44407 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T465 44698-44700 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T467 44705-44707 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T469 44711-44713 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T471 44863-44865 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T473 44872-44874 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T475 45035-45039 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T477 45465-45467 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T479 45472-45474 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T481 45478-45480 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T483 45525-45527 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T485 45585-45588 Chemical denotes PAH http://purl.obolibrary.org/obo/CHEBI_104011|http://purl.obolibrary.org/obo/CHEBI_31204|http://purl.obolibrary.org/obo/CHEBI_33848|http://purl.obolibrary.org/obo/CHEBI_53305
T489 45656-45658 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T491 45663-45665 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T493 45669-45671 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T495 45675-45677 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T497 45681-45683 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T499 45687-45689 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T501 45694-45696 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T503 45838-45841 Chemical denotes PAH http://purl.obolibrary.org/obo/CHEBI_104011|http://purl.obolibrary.org/obo/CHEBI_31204|http://purl.obolibrary.org/obo/CHEBI_33848|http://purl.obolibrary.org/obo/CHEBI_53305
T507 45901-45905 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T509 45995-45999 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T511 46066-46070 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T513 46147-46151 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T515 46182-46187 Chemical denotes ZnCl2 http://purl.obolibrary.org/obo/CHEBI_49976
T516 46234-46238 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T518 46315-46319 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T520 46402-46406 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T522 46445-46452 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T523 46479-46482 Chemical denotes Zn2 http://purl.obolibrary.org/obo/CHEBI_37256
T524 46508-46512 Chemical denotes ions http://purl.obolibrary.org/obo/CHEBI_24870
T525 46540-46544 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T527 46586-46590 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T529 46647-46651 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T531 46714-46724 Chemical denotes zinc oxide http://purl.obolibrary.org/obo/CHEBI_36560
T532 46714-46718 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T534 46719-46724 Chemical denotes oxide http://purl.obolibrary.org/obo/CHEBI_25741|http://purl.obolibrary.org/obo/CHEBI_29356
T536 46755-46768 Chemical denotes zinc chloride http://purl.obolibrary.org/obo/CHEBI_49976
T537 46755-46759 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T539 46760-46768 Chemical denotes chloride http://purl.obolibrary.org/obo/CHEBI_17996
T540 46769-46773 Chemical denotes salt http://purl.obolibrary.org/obo/CHEBI_24866|http://purl.obolibrary.org/obo/CHEBI_26710
T542 46838-46853 Chemical denotes food components http://purl.obolibrary.org/obo/CHEBI_78295
T543 46945-46955 Chemical denotes folic acid http://purl.obolibrary.org/obo/CHEBI_27470
T544 46951-46955 Chemical denotes acid http://purl.obolibrary.org/obo/CHEBI_37527
T545 46990-46994 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T547 47009-47013 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T549 47044-47048 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T551 47085-47088 Chemical denotes Zn2 http://purl.obolibrary.org/obo/CHEBI_37256
T552 47127-47138 Chemical denotes amino acids http://purl.obolibrary.org/obo/CHEBI_33709
T553 47127-47132 Chemical denotes amino http://purl.obolibrary.org/obo/CHEBI_46882
T554 47133-47138 Chemical denotes acids http://purl.obolibrary.org/obo/CHEBI_37527
T555 47140-47142 Chemical denotes AA http://purl.obolibrary.org/obo/CHEBI_15843|http://purl.obolibrary.org/obo/CHEBI_72816|http://purl.obolibrary.org/obo/CHEBI_33709
T558 47184-47192 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T559 47199-47202 Chemical denotes Zn2 http://purl.obolibrary.org/obo/CHEBI_37256
T560 47232-47244 Chemical denotes amine groups http://purl.obolibrary.org/obo/CHEBI_51142
T561 47232-47237 Chemical denotes amine http://purl.obolibrary.org/obo/CHEBI_32952
T562 47261-47267 Chemical denotes anions http://purl.obolibrary.org/obo/CHEBI_22563
T563 47366-47371 Chemical denotes ZnCl2 http://purl.obolibrary.org/obo/CHEBI_49976
T564 47372-47376 Chemical denotes salt http://purl.obolibrary.org/obo/CHEBI_24866|http://purl.obolibrary.org/obo/CHEBI_26710
T566 47380-47382 Chemical denotes Zn http://purl.obolibrary.org/obo/CHEBI_27363
T567 47383-47385 Chemical denotes AA http://purl.obolibrary.org/obo/CHEBI_15843|http://purl.obolibrary.org/obo/CHEBI_72816|http://purl.obolibrary.org/obo/CHEBI_33709
T570 47429-47433 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T572 47611-47615 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T574 47628-47630 Chemical denotes AA http://purl.obolibrary.org/obo/CHEBI_15843|http://purl.obolibrary.org/obo/CHEBI_72816|http://purl.obolibrary.org/obo/CHEBI_33709
T577 47643-47647 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T579 47648-47653 Chemical denotes salts http://purl.obolibrary.org/obo/CHEBI_24866
T580 47704-47708 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T582 47724-47728 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T584 47729-47731 Chemical denotes AA http://purl.obolibrary.org/obo/CHEBI_15843|http://purl.obolibrary.org/obo/CHEBI_72816|http://purl.obolibrary.org/obo/CHEBI_33709
T587 47745-47747 Chemical denotes AA http://purl.obolibrary.org/obo/CHEBI_15843|http://purl.obolibrary.org/obo/CHEBI_72816|http://purl.obolibrary.org/obo/CHEBI_33709
T590 47810-47812 Chemical denotes AA http://purl.obolibrary.org/obo/CHEBI_15843|http://purl.obolibrary.org/obo/CHEBI_72816|http://purl.obolibrary.org/obo/CHEBI_33709
T593 47877-47881 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T595 47882-47884 Chemical denotes AA http://purl.obolibrary.org/obo/CHEBI_15843|http://purl.obolibrary.org/obo/CHEBI_72816|http://purl.obolibrary.org/obo/CHEBI_33709
T598 47937-47944 Chemical denotes insulin http://purl.obolibrary.org/obo/CHEBI_145810
T599 48020-48024 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T601 48156-48160 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T603 48311-48323 Chemical denotes dietary zinc http://purl.obolibrary.org/obo/CHEBI_29105
T604 48319-48323 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T606 48383-48386 Chemical denotes Zn2 http://purl.obolibrary.org/obo/CHEBI_37256
T607 48448-48452 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T609 48475-48482 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T610 48534-48537 Chemical denotes Zn2 http://purl.obolibrary.org/obo/CHEBI_37256
T611 48566-48568 Chemical denotes AA http://purl.obolibrary.org/obo/CHEBI_15843|http://purl.obolibrary.org/obo/CHEBI_72816|http://purl.obolibrary.org/obo/CHEBI_33709
T614 48579-48582 Chemical denotes Zn2 http://purl.obolibrary.org/obo/CHEBI_37256
T615 48624-48628 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T617 48707-48711 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T619 48759-48762 Chemical denotes Zn2 http://purl.obolibrary.org/obo/CHEBI_37256
T620 48817-48821 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T622 48904-48907 Chemical denotes Zn2 http://purl.obolibrary.org/obo/CHEBI_37256
T42913 49049-49053 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T61190 49140-49143 Chemical denotes Zn2 http://purl.obolibrary.org/obo/CHEBI_37256
T14672 49343-49347 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T35422 49366-49370 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T6498 49460-49464 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T46147 49557-49561 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T80373 49694-49698 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T99687 49903-49907 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T73526 49952-49964 Chemical denotes amyloid beta http://purl.obolibrary.org/obo/CHEBI_64645
T25126 49960-49964 Chemical denotes beta http://purl.obolibrary.org/obo/CHEBI_10545
T81124 49965-49972 Chemical denotes peptide http://purl.obolibrary.org/obo/CHEBI_16670
T69400 50059-50067 Chemical denotes zinc ion http://purl.obolibrary.org/obo/CHEBI_27365
T43909 50059-50063 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T90698 50064-50067 Chemical denotes ion http://purl.obolibrary.org/obo/CHEBI_24870
T23 50224-50227 Chemical denotes Zn2 http://purl.obolibrary.org/obo/CHEBI_37256
T11305 50256-50262 Chemical denotes metals http://purl.obolibrary.org/obo/CHEBI_33521
T25 50346-50350 Chemical denotes ions http://purl.obolibrary.org/obo/CHEBI_24870
T8552 50519-50522 Chemical denotes Zn2 http://purl.obolibrary.org/obo/CHEBI_37256
T27 50574-50578 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T46411 50617-50621 Chemical denotes EDTA http://purl.obolibrary.org/obo/CHEBI_42191|http://purl.obolibrary.org/obo/CHEBI_64755
T9001 50628-50636 Chemical denotes chelator http://purl.obolibrary.org/obo/CHEBI_38161
T72606 50789-50796 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T34459 50812-50816 Chemical denotes ions http://purl.obolibrary.org/obo/CHEBI_24870
T8109 50825-50829 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T36 50846-50855 Chemical denotes molecules http://purl.obolibrary.org/obo/CHEBI_25367
T35424 50869-50879 Chemical denotes fatty acid http://purl.obolibrary.org/obo/CHEBI_35366
T51103 50875-50879 Chemical denotes acid http://purl.obolibrary.org/obo/CHEBI_37527
T4450 50881-50884 Chemical denotes FFA http://purl.obolibrary.org/obo/CHEBI_42638|http://purl.obolibrary.org/obo/CHEBI_35366
T26241 50962-50969 Chemical denotes carrier http://purl.obolibrary.org/obo/CHEBI_78059
T16974 50979-50983 Chemical denotes ions http://purl.obolibrary.org/obo/CHEBI_24870
T80700 51000-51009 Chemical denotes molecules http://purl.obolibrary.org/obo/CHEBI_25367
T93666 51045-51054 Chemical denotes molecules http://purl.obolibrary.org/obo/CHEBI_25367
T47509 51181-51184 Chemical denotes FFA http://purl.obolibrary.org/obo/CHEBI_42638|http://purl.obolibrary.org/obo/CHEBI_35366
T36449 51189-51193 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T66182 51246-51252 Chemical denotes carbon http://purl.obolibrary.org/obo/CHEBI_27594|http://purl.obolibrary.org/obo/CHEBI_33415
T10714 51253-51258 Chemical denotes atoms http://purl.obolibrary.org/obo/CHEBI_33250
T87033 51297-51300 Chemical denotes Zn2 http://purl.obolibrary.org/obo/CHEBI_37256
T84664 51409-51413 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T4649 51549-51553 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T68380 51696-51699 Chemical denotes Zn2 http://purl.obolibrary.org/obo/CHEBI_37256
T39438 51706-51718 Chemical denotes amyloid beta http://purl.obolibrary.org/obo/CHEBI_64645
T95341 51714-51718 Chemical denotes beta http://purl.obolibrary.org/obo/CHEBI_10545
T90891 51719-51727 Chemical denotes peptides http://purl.obolibrary.org/obo/CHEBI_16670
T79507 51785-51788 Chemical denotes Zn2 http://purl.obolibrary.org/obo/CHEBI_37256
T11769 51876-51883 Chemical denotes heparin http://purl.obolibrary.org/obo/CHEBI_28304
T88200 52175-52179 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T72355 52245-52248 Chemical denotes RAS http://purl.obolibrary.org/obo/CHEBI_63620
T765 52414-52418 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T83715 52479-52484 Chemical denotes ZnCl2 http://purl.obolibrary.org/obo/CHEBI_49976
T56869 52485-52488 Chemical denotes ZnO http://purl.obolibrary.org/obo/CHEBI_36560
T70147 52489-52505 Chemical denotes hexachloroethane http://purl.obolibrary.org/obo/CHEBI_39227
T4674 52761-52765 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T51227 52981-52985 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T75 54472-54482 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T47611 54602-54611 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T93730 54688-54696 Chemical denotes electron http://purl.obolibrary.org/obo/CHEBI_10545
T82543 54934-54941 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T74998 55008-55015 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T37661 55276-55284 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T59859 55373-55380 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T68655 55558-55566 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T22243 55648-55657 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T66791 55706-55715 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T85 55804-55812 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T26019 55859-55873 Chemical denotes ACE2 inhibitor http://purl.obolibrary.org/obo/CHEBI_147289
T54501 55864-55873 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T75789 55945-55960 Chemical denotes racemic mixture http://purl.obolibrary.org/obo/CHEBI_60911
T7082 55953-55960 Chemical denotes mixture http://purl.obolibrary.org/obo/CHEBI_60004
T14426 56147-56162 Chemical denotes racemic mixture http://purl.obolibrary.org/obo/CHEBI_60911
T52319 56155-56162 Chemical denotes mixture http://purl.obolibrary.org/obo/CHEBI_60004
T74419 56298-56308 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T93878 56415-56423 Chemical denotes racemate http://purl.obolibrary.org/obo/CHEBI_60911
T90533 56568-56576 Chemical denotes racemate http://purl.obolibrary.org/obo/CHEBI_60911
T46386 56687-56697 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T96 56901-56909 Chemical denotes racemate http://purl.obolibrary.org/obo/CHEBI_60911
T36982 57043-57057 Chemical denotes ACE2 inhibitor http://purl.obolibrary.org/obo/CHEBI_147289
T92521 57048-57057 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T41578 57255-57264 Chemical denotes disulfide http://purl.obolibrary.org/obo/CHEBI_48343
T100 57289-57299 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T22298 57656-57658 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T60880 57890-57898 Chemical denotes racemate http://purl.obolibrary.org/obo/CHEBI_60911
T91051 58012-58022 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T32362 58327-58341 Chemical denotes ACE2 inhibitor http://purl.obolibrary.org/obo/CHEBI_147289
T91312 58332-58341 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T3770 58364-58373 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T42358 58751-58753 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T84420 59005-59010 Chemical denotes water http://purl.obolibrary.org/obo/CHEBI_15377
T69860 59042-59046 Chemical denotes male http://purl.obolibrary.org/obo/CHEBI_30780
T80273 59377-59384 Chemical denotes nucleus http://purl.obolibrary.org/obo/CHEBI_33252
T43819 59732-59741 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T58470 59844-59851 Chemical denotes peptide http://purl.obolibrary.org/obo/CHEBI_16670
T85380 59852-59866 Chemical denotes ACE2 inhibitor http://purl.obolibrary.org/obo/CHEBI_147289
T2332 59857-59866 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T27493 59991-60000 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T56128 60225-60234 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T23596 60373-60388 Chemical denotes ACE2 inhibitors http://purl.obolibrary.org/obo/CHEBI_147289
T10113 60378-60388 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T6036 60702-60706 Chemical denotes male http://purl.obolibrary.org/obo/CHEBI_30780
T60127 60767-60770 Chemical denotes C16 http://purl.obolibrary.org/obo/CHEBI_15756
T121 60826-60834 Chemical denotes solution http://purl.obolibrary.org/obo/CHEBI_75958
T93537 60860-60865 Chemical denotes water http://purl.obolibrary.org/obo/CHEBI_15377
T27633 61017-61022 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T73784 61825-61831 Chemical denotes cation http://purl.obolibrary.org/obo/CHEBI_36916
T52408 61832-61837 Chemical denotes anion http://purl.obolibrary.org/obo/CHEBI_22563
T48403 61888-61892 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T22224 61941-61945 Chemical denotes EDTA http://purl.obolibrary.org/obo/CHEBI_42191|http://purl.obolibrary.org/obo/CHEBI_64755
T5627 61949-61955 Chemical denotes cation http://purl.obolibrary.org/obo/CHEBI_36916
T70245 61956-61964 Chemical denotes chelator http://purl.obolibrary.org/obo/CHEBI_38161
T22254 62036-62040 Chemical denotes EDTA http://purl.obolibrary.org/obo/CHEBI_42191|http://purl.obolibrary.org/obo/CHEBI_64755
T68253 62089-62092 Chemical denotes Zn2 http://purl.obolibrary.org/obo/CHEBI_37256
T95886 62237-62240 Chemical denotes Zn2 http://purl.obolibrary.org/obo/CHEBI_37256
T85661 62278-62282 Chemical denotes iron http://purl.obolibrary.org/obo/CHEBI_18248
T94180 62340-62344 Chemical denotes iron http://purl.obolibrary.org/obo/CHEBI_18248
T30043 62457-62461 Chemical denotes ions http://purl.obolibrary.org/obo/CHEBI_24870
T94269 62513-62517 Chemical denotes EDTA http://purl.obolibrary.org/obo/CHEBI_42191|http://purl.obolibrary.org/obo/CHEBI_64755
T6513 62531-62534 Chemical denotes Zn2 http://purl.obolibrary.org/obo/CHEBI_37256
T20754 62653-62657 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T40517 62727-62731 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T43428 62761-62765 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T36225 62860-62864 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T30838 62919-62923 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T53337 63409-63430 Chemical denotes iron chelating agents http://purl.obolibrary.org/obo/CHEBI_38157
T25372 63409-63413 Chemical denotes iron http://purl.obolibrary.org/obo/CHEBI_18248
T27100 63414-63430 Chemical denotes chelating agents http://purl.obolibrary.org/obo/CHEBI_38161
T154 63462-63470 Chemical denotes zinc ion http://purl.obolibrary.org/obo/CHEBI_27365
T155 63462-63466 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T83733 63467-63470 Chemical denotes ion http://purl.obolibrary.org/obo/CHEBI_24870
T158 63568-63584 Chemical denotes chelating agents http://purl.obolibrary.org/obo/CHEBI_38161
T43731 63603-63607 Chemical denotes ions http://purl.obolibrary.org/obo/CHEBI_24870
T75520 63616-63620 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T86735 63728-63732 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T55396 63790-63794 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T79616 63966-63970 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T58337 64028-64044 Chemical denotes chelating agents http://purl.obolibrary.org/obo/CHEBI_38161
T33902 64083-64087 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T76669 64338-64342 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T173 64357-64366 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T19266 64411-64415 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T6825 64514-64525 Chemical denotes chloroquine http://purl.obolibrary.org/obo/CHEBI_3638
T177 64565-64569 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T70735 64712-64716 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T181 64731-64735 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T183 64774-64777 Chemical denotes Zn2 http://purl.obolibrary.org/obo/CHEBI_37256
T41696 64853-64864 Chemical denotes chloroquine http://purl.obolibrary.org/obo/CHEBI_3638
T185 65013-65016 Chemical denotes Zn2 http://purl.obolibrary.org/obo/CHEBI_37256
T99734 65193-65196 Chemical denotes Zn2 http://purl.obolibrary.org/obo/CHEBI_37256
T86289 65325-65336 Chemical denotes chloroquine http://purl.obolibrary.org/obo/CHEBI_3638
T188 65368-65374 Chemical denotes cation http://purl.obolibrary.org/obo/CHEBI_36916
T41096 65375-65391 Chemical denotes chelating agents http://purl.obolibrary.org/obo/CHEBI_38161
T99407 65559-65562 Chemical denotes RAS http://purl.obolibrary.org/obo/CHEBI_63620
T191 65664-65680 Chemical denotes chelating agents http://purl.obolibrary.org/obo/CHEBI_38161
T97596 66067-66071 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T61973 66083-66087 Chemical denotes EDTA http://purl.obolibrary.org/obo/CHEBI_42191|http://purl.obolibrary.org/obo/CHEBI_64755
T73647 66201-66205 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T92153 66285-66301 Chemical denotes chelating agents http://purl.obolibrary.org/obo/CHEBI_38161
T53011 66493-66496 Chemical denotes RAS http://purl.obolibrary.org/obo/CHEBI_63620
T9812 66572-66575 Chemical denotes RAS http://purl.obolibrary.org/obo/CHEBI_63620
T87402 66626-66635 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T44967 66719-66728 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T3727 66826-66833 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T14121 66887-66889 Chemical denotes AA http://purl.obolibrary.org/obo/CHEBI_15843|http://purl.obolibrary.org/obo/CHEBI_72816
T84458 66907-66914 Chemical denotes peptide http://purl.obolibrary.org/obo/CHEBI_16670
T69057 66989-66991 Chemical denotes AA http://purl.obolibrary.org/obo/CHEBI_15843|http://purl.obolibrary.org/obo/CHEBI_72816
T91071 67004-67008 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T19503 67024-67028 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T46424 67042-67053 Chemical denotes amino acids http://purl.obolibrary.org/obo/CHEBI_33709
T65597 67042-67047 Chemical denotes amino http://purl.obolibrary.org/obo/CHEBI_46882
T8159 67048-67053 Chemical denotes acids http://purl.obolibrary.org/obo/CHEBI_37527
T14330 67105-67107 Chemical denotes AA http://purl.obolibrary.org/obo/CHEBI_15843|http://purl.obolibrary.org/obo/CHEBI_72816
T85515 67125-67132 Chemical denotes peptide http://purl.obolibrary.org/obo/CHEBI_16670
T32788 67492-67502 Chemical denotes amino acid http://purl.obolibrary.org/obo/CHEBI_33709
T79856 67492-67497 Chemical denotes amino http://purl.obolibrary.org/obo/CHEBI_46882
T15688 67498-67502 Chemical denotes acid http://purl.obolibrary.org/obo/CHEBI_37527
T92075 67506-67514 Chemical denotes molecule http://purl.obolibrary.org/obo/CHEBI_25367
T25025 67589-67593 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T1810 67625-67640 Chemical denotes ACE2 inhibitors http://purl.obolibrary.org/obo/CHEBI_147289
T34831 67630-67640 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T28604 67642-67650 Chemical denotes agmatine http://purl.obolibrary.org/obo/CHEBI_17431|http://purl.obolibrary.org/obo/CHEBI_58145
T22491 67667-67675 Chemical denotes arginine http://purl.obolibrary.org/obo/CHEBI_16467|http://purl.obolibrary.org/obo/CHEBI_29016|http://purl.obolibrary.org/obo/CHEBI_32696
T28753 67728-67742 Chemical denotes ACE2 inhibitor http://purl.obolibrary.org/obo/CHEBI_147289
T2369 67733-67742 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T78716 67772-67780 Chemical denotes molecule http://purl.obolibrary.org/obo/CHEBI_25367
T50950 67906-67913 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T79228 68005-68019 Chemical denotes ACE2 inhibitor http://purl.obolibrary.org/obo/CHEBI_147289
T7622 68010-68019 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T71996 68100-68108 Chemical denotes agmatine http://purl.obolibrary.org/obo/CHEBI_17431|http://purl.obolibrary.org/obo/CHEBI_58145
T88126 68568-68576 Chemical denotes agmatine http://purl.obolibrary.org/obo/CHEBI_17431|http://purl.obolibrary.org/obo/CHEBI_58145
T22869 68665-68673 Chemical denotes agmatine http://purl.obolibrary.org/obo/CHEBI_17431|http://purl.obolibrary.org/obo/CHEBI_58145
T85420 68760-68768 Chemical denotes agmatine http://purl.obolibrary.org/obo/CHEBI_17431|http://purl.obolibrary.org/obo/CHEBI_58145
T82274 68769-68776 Chemical denotes sulfate http://purl.obolibrary.org/obo/CHEBI_16189
T71277 68846-68862 Chemical denotes chelating agents http://purl.obolibrary.org/obo/CHEBI_38161
T50847 68877-68887 Chemical denotes folic acid http://purl.obolibrary.org/obo/CHEBI_27470
T11602 68883-68887 Chemical denotes acid http://purl.obolibrary.org/obo/CHEBI_37527
T248 68896-68912 Chemical denotes chelating agents http://purl.obolibrary.org/obo/CHEBI_38161
T86761 68947-68951 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T13737 69048-69061 Chemical denotes nicotianamine http://purl.obolibrary.org/obo/CHEBI_25520|http://purl.obolibrary.org/obo/CHEBI_58249
T39108 69134-69142 Chemical denotes chelator http://purl.obolibrary.org/obo/CHEBI_38161
T254 69175-69188 Chemical denotes metal cations http://purl.obolibrary.org/obo/CHEBI_25213
T55642 69181-69188 Chemical denotes cations http://purl.obolibrary.org/obo/CHEBI_36916
T80399 69190-69203 Chemical denotes Nicotianamine http://purl.obolibrary.org/obo/CHEBI_17721
T257 69251-69255 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T41173 69357-69361 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T99158 69391-69396 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T63352 69416-69424 Chemical denotes minerals http://purl.obolibrary.org/obo/CHEBI_46662
T15395 69631-69636 Chemical denotes water http://purl.obolibrary.org/obo/CHEBI_15377
T62193 69644-69650 Chemical denotes metals http://purl.obolibrary.org/obo/CHEBI_33521
T31321 69652-69659 Chemical denotes cations http://purl.obolibrary.org/obo/CHEBI_36916
T24234 69669-69675 Chemical denotes toxins http://purl.obolibrary.org/obo/CHEBI_27026
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T45243 70052-70062 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
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T12810 99663-99667 Chemical denotes salt http://purl.obolibrary.org/obo/CHEBI_24866|http://purl.obolibrary.org/obo/CHEBI_26710
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T95254 113971-113974 Chemical denotes RAS http://purl.obolibrary.org/obo/CHEBI_63620
T71857 114027-114030 Chemical denotes RAS http://purl.obolibrary.org/obo/CHEBI_63620
T21173 114031-114040 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T63000 114100-114103 Chemical denotes RAS http://purl.obolibrary.org/obo/CHEBI_63620
T69122 114215-114218 Chemical denotes RAS http://purl.obolibrary.org/obo/CHEBI_63620

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T1 100140-100153 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammations
T2 101228-101240 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T3 102788-102805 http://purl.obolibrary.org/obo/GO_0007596 denotes blood/coagulation
T4 102794-102805 http://purl.obolibrary.org/obo/GO_0050817 denotes coagulation
T5 104794-104803 http://purl.obolibrary.org/obo/GO_0009058 denotes synthesis
T6 107168-107179 http://purl.obolibrary.org/obo/GO_0071578 denotes zinc uptake
T7 107173-107179 http://purl.obolibrary.org/obo/GO_0098739 denotes uptake
T8 107173-107179 http://purl.obolibrary.org/obo/GO_0098657 denotes uptake
T9 107378-107387 http://purl.obolibrary.org/obo/GO_0007588 denotes excretion
T10 108717-108738 http://purl.obolibrary.org/obo/GO_0003094 denotes glomerular filtration
T11 111024-111036 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T12 113825-113835 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T46890 1625-1630 http://purl.obolibrary.org/obo/GO_0007568 denotes Aging
T87124 2623-2639 http://purl.obolibrary.org/obo/GO_0016032 denotes Viral infections
T52159 5742-5757 http://purl.obolibrary.org/obo/GO_0016032 denotes viral infection
T47565 6205-6220 http://purl.obolibrary.org/obo/GO_0016032 denotes viral infection
T51579 6983-6998 http://purl.obolibrary.org/obo/GO_0010467 denotes gene expression
T1132 7671-7683 http://purl.obolibrary.org/obo/GO_0009405 denotes pathogenesis
T66720 7813-7822 http://purl.obolibrary.org/obo/GO_0009058 denotes formation
T54884 9475-9497 http://purl.obolibrary.org/obo/GO_0006865 denotes amino acid transporter
T58005 11193-11206 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T37916 11759-11766 http://purl.obolibrary.org/obo/GO_0009606 denotes tropism
T72358 12551-12558 http://purl.obolibrary.org/obo/GO_0009606 denotes tropism
T98067 13542-13558 http://purl.obolibrary.org/obo/GO_0006955 denotes immune responses
T13 14280-14294 http://purl.obolibrary.org/obo/GO_0042311 denotes vasodilatative
T14 14780-14796 http://purl.obolibrary.org/obo/GO_0042310 denotes vasoconstriction
T15 14811-14823 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T16 14835-14853 http://purl.obolibrary.org/obo/GO_0008283 denotes cell proliferation
T17 15372-15384 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T18 16335-16344 http://purl.obolibrary.org/obo/GO_0005243 denotes connexins
T19 16370-16379 http://purl.obolibrary.org/obo/GO_0009058 denotes formation
T20 17018-17029 http://purl.obolibrary.org/obo/GO_0050817 denotes coagulation
T21 17175-17184 http://purl.obolibrary.org/obo/GO_0009058 denotes formation
T22 17329-17349 http://purl.obolibrary.org/obo/GO_0070527 denotes platelet aggregation
T23 17792-17803 http://purl.obolibrary.org/obo/GO_0050817 denotes coagulation
T24 17855-17866 http://purl.obolibrary.org/obo/GO_0050817 denotes coagulation
T25 18051-18060 http://purl.obolibrary.org/obo/GO_0009058 denotes synthesis
T26 18424-18443 http://purl.obolibrary.org/obo/GO_0001666 denotes response to hypoxia
T27 19292-19302 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T28 19782-19801 http://purl.obolibrary.org/obo/GO_0001666 denotes response to hypoxia
T29 20569-20581 http://purl.obolibrary.org/obo/GO_0042311 denotes vasodilation
T30 21080-21089 http://purl.obolibrary.org/obo/GO_0046903 denotes secretion
T31 21542-21551 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T32 21747-21766 http://purl.obolibrary.org/obo/GO_0001816 denotes cytokine production
T33 21819-21831 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T34 22374-22389 http://purl.obolibrary.org/obo/GO_0016032 denotes viral infection
T35 23192-23201 http://purl.obolibrary.org/obo/GO_0097194 denotes apoptosis
T36 23192-23201 http://purl.obolibrary.org/obo/GO_0006915 denotes apoptosis
T37 23315-23327 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T38 23770-23779 http://purl.obolibrary.org/obo/GO_0046903 denotes secretion
T39 23855-23878 http://purl.obolibrary.org/obo/GO_0007263 denotes nitric oxide signalling
T40 23868-23878 http://purl.obolibrary.org/obo/GO_0023052 denotes signalling
T41 23895-23911 http://purl.obolibrary.org/obo/GO_0032613 denotes IL-10 production
T42 24159-24175 http://purl.obolibrary.org/obo/GO_0006955 denotes immune responses
T43 24219-24231 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T44 24891-24906 http://purl.obolibrary.org/obo/GO_0010467 denotes gene expression
T45 25029-25042 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T46 26070-26080 http://purl.obolibrary.org/obo/GO_0023052 denotes signalling
T47 26394-26407 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T48 26546-26556 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T49 26850-26867 http://purl.obolibrary.org/obo/GO_0038024 denotes receptor activity
T50 28361-28370 http://purl.obolibrary.org/obo/GO_0046903 denotes secretion
T51 29375-29384 http://purl.obolibrary.org/obo/GO_0046903 denotes secretion
T52 29452-29461 http://purl.obolibrary.org/obo/GO_0046903 denotes secretion
T53 30015-30024 http://purl.obolibrary.org/obo/GO_0046903 denotes secretion
T54 30160-30175 http://purl.obolibrary.org/obo/GO_0016032 denotes viral infection
T55 30447-30456 http://purl.obolibrary.org/obo/GO_0009058 denotes synthesis
T56 30683-30697 http://purl.obolibrary.org/obo/GO_0042311 denotes vasodilatative
T57 30728-30738 http://purl.obolibrary.org/obo/GO_0009056 denotes catabolism
T58 31039-31061 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammatory responses
T59 31408-31417 http://purl.obolibrary.org/obo/GO_0009058 denotes synthesis
T60 32210-32221 http://purl.obolibrary.org/obo/GO_0009056 denotes degradation
T61 32255-32264 http://purl.obolibrary.org/obo/GO_0007588 denotes excretion
T62 32887-32899 http://purl.obolibrary.org/obo/GO_0009405 denotes pathogenesis
T63 34112-34136 http://purl.obolibrary.org/obo/GO_0008237 denotes metalloprotease activity
T64 34862-34878 http://purl.obolibrary.org/obo/GO_0006955 denotes immune responses
T65 34953-34978 http://purl.obolibrary.org/obo/GO_0002250 denotes adaptive immune responses
T66 34991-35005 http://purl.obolibrary.org/obo/GO_0005319 denotes apolipoprotein
T67 35008-35020 http://purl.obolibrary.org/obo/GO_0016556 denotes mRNA editing
T68 36741-36752 http://purl.obolibrary.org/obo/GO_0009056 denotes degradation
T69 36994-37003 http://purl.obolibrary.org/obo/GO_0007588 denotes excretion
T70 39314-39326 http://purl.obolibrary.org/obo/GO_0042311 denotes vasodilation
T71 40419-40430 http://purl.obolibrary.org/obo/GO_0006810 denotes transporter
T72 42301-42312 http://purl.obolibrary.org/obo/GO_0071578 denotes zinc import
T73 43310-43319 http://purl.obolibrary.org/obo/GO_0007588 denotes excretion
T74 43478-43487 http://purl.obolibrary.org/obo/GO_0007588 denotes excretion
T75 45095-45113 http://purl.obolibrary.org/obo/GO_0001816 denotes cytokine secretion
T76 45104-45113 http://purl.obolibrary.org/obo/GO_0046903 denotes secretion
T77 45293-45308 http://purl.obolibrary.org/obo/GO_0006955 denotes immune response
T78 46066-46082 http://purl.obolibrary.org/obo/GO_0055069 denotes zinc homeostasis
T79 46066-46082 http://purl.obolibrary.org/obo/GO_0006882 denotes zinc homeostasis
T80 46071-46082 http://purl.obolibrary.org/obo/GO_0042592 denotes homeostasis
T81 46234-46250 http://purl.obolibrary.org/obo/GO_0055069 denotes zinc homeostasis
T82 46234-46250 http://purl.obolibrary.org/obo/GO_0006882 denotes zinc homeostasis
T83 46239-46250 http://purl.obolibrary.org/obo/GO_0042592 denotes homeostasis
T84 46402-46419 http://purl.obolibrary.org/obo/GO_0006829 denotes zinc transporters
T85 47049-47058 http://purl.obolibrary.org/obo/GO_0007588 denotes excretion
T86 47515-47536 http://purl.obolibrary.org/obo/GO_0050892 denotes intestinal absorption
T87 47694-47700 http://purl.obolibrary.org/obo/GO_0098739 denotes uptake
T88 47694-47700 http://purl.obolibrary.org/obo/GO_0098657 denotes uptake
T89 47714-47720 http://purl.obolibrary.org/obo/GO_0098739 denotes uptake
T90 47714-47720 http://purl.obolibrary.org/obo/GO_0098657 denotes uptake
T91 47813-47824 http://purl.obolibrary.org/obo/GO_0006810 denotes transporter
T92 47885-47891 http://purl.obolibrary.org/obo/GO_0098739 denotes uptake
T93 47885-47891 http://purl.obolibrary.org/obo/GO_0098657 denotes uptake
T94 47945-47957 http://purl.obolibrary.org/obo/GO_0009058 denotes biosynthesis
T95 47958-47967 http://purl.obolibrary.org/obo/GO_0046903 denotes secretion
T96 48111-48120 http://purl.obolibrary.org/obo/GO_0009058 denotes synthesis
T97 48221-48242 http://purl.obolibrary.org/obo/GO_0050892 denotes intestinal absorption
T98 48253-48262 http://purl.obolibrary.org/obo/GO_0007588 denotes excretion
T99 48448-48464 http://purl.obolibrary.org/obo/GO_0006829 denotes zinc transporter
T100 48817-48828 http://purl.obolibrary.org/obo/GO_0071578 denotes zinc uptake
T101 48822-48828 http://purl.obolibrary.org/obo/GO_0098739 denotes uptake
T102 48822-48828 http://purl.obolibrary.org/obo/GO_0098657 denotes uptake
T103 49074-49083 http://purl.obolibrary.org/obo/GO_0097194 denotes apoptosis
T104 49074-49083 http://purl.obolibrary.org/obo/GO_0006915 denotes apoptosis
T105 49659-49669 http://purl.obolibrary.org/obo/GO_0008152 denotes metabolism
T106 49671-49688 http://purl.obolibrary.org/obo/GO_0007596 denotes blood coagulation
T107 49677-49688 http://purl.obolibrary.org/obo/GO_0050817 denotes coagulation
T108 49699-49709 http://purl.obolibrary.org/obo/GO_0023052 denotes signalling
T109 49819-49831 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T110 49980-49989 http://purl.obolibrary.org/obo/GO_0009058 denotes formation
T111 50574-50585 http://purl.obolibrary.org/obo/GO_0071578 denotes zinc uptake
T112 50579-50585 http://purl.obolibrary.org/obo/GO_0098739 denotes uptake
T113 50579-50585 http://purl.obolibrary.org/obo/GO_0098657 denotes uptake
T114 50675-50685 http://purl.obolibrary.org/obo/GO_0008219 denotes cell death
T115 50779-50788 http://purl.obolibrary.org/obo/GO_0006810 denotes transport
T116 51594-51600 http://purl.obolibrary.org/obo/GO_0140352 denotes efflux
T117 51594-51600 http://purl.obolibrary.org/obo/GO_0140115 denotes efflux
T118 51746-51755 http://purl.obolibrary.org/obo/GO_0009058 denotes formation
T119 55924-55933 http://purl.obolibrary.org/obo/GO_0009058 denotes synthesis
T120 57386-57397 http://purl.obolibrary.org/obo/GO_0006508 denotes proteolysis
T121 57659-57670 http://purl.obolibrary.org/obo/GO_0009056 denotes degradation
T122 59445-59451 http://purl.obolibrary.org/obo/GO_0060004 denotes reflex
T123 59505-59511 http://purl.obolibrary.org/obo/GO_0060004 denotes reflex
T124 60191-60203 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T125 62967-62973 http://purl.obolibrary.org/obo/GO_0040007 denotes growth
T126 62975-62995 http://purl.obolibrary.org/obo/GO_0048666 denotes neuronal development
T127 63857-63875 http://purl.obolibrary.org/obo/GO_0044249 denotes cellular synthesis
T128 63866-63875 http://purl.obolibrary.org/obo/GO_0009058 denotes synthesis
T129 63903-63912 http://purl.obolibrary.org/obo/GO_0009058 denotes synthesis
T130 64134-64143 http://purl.obolibrary.org/obo/GO_0009058 denotes synthesis
T131 64565-64576 http://purl.obolibrary.org/obo/GO_0071578 denotes zinc uptake
T132 64570-64576 http://purl.obolibrary.org/obo/GO_0098739 denotes uptake
T133 64570-64576 http://purl.obolibrary.org/obo/GO_0098657 denotes uptake
T134 64930-64949 http://purl.obolibrary.org/obo/GO_0030168 denotes platelet activation
T135 64978-64997 http://purl.obolibrary.org/obo/GO_0030168 denotes platelet activation
T136 65143-65152 http://purl.obolibrary.org/obo/GO_0009058 denotes formation
T137 66072-66081 http://purl.obolibrary.org/obo/GO_0007588 denotes excretion
T138 68314-68337 http://purl.obolibrary.org/obo/GO_0009889 denotes regulating NO synthesis
T139 68328-68337 http://purl.obolibrary.org/obo/GO_0009058 denotes synthesis
T140 68952-68973 http://purl.obolibrary.org/obo/GO_0050892 denotes intestinal absorption
T141 70263-70278 http://purl.obolibrary.org/obo/GO_0016032 denotes viral infection
T142 77080-77095 http://purl.obolibrary.org/obo/GO_0016032 denotes viral infection
T143 77697-77706 http://purl.obolibrary.org/obo/GO_0007588 denotes excretion
T144 78067-78076 http://purl.obolibrary.org/obo/GO_0007588 denotes excretion
T145 78226-78235 http://purl.obolibrary.org/obo/GO_0007588 denotes excretion
T146 79577-79582 http://purl.obolibrary.org/obo/GO_0030431 denotes sleep
T147 79935-79940 http://purl.obolibrary.org/obo/GO_0030431 denotes sleep
T148 80036-80048 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T149 80631-80636 http://purl.obolibrary.org/obo/GO_0030431 denotes sleep
T150 81589-81595 http://purl.obolibrary.org/obo/GO_0007613 denotes memory
T151 81599-81614 http://purl.obolibrary.org/obo/GO_0006955 denotes immune response
T152 84650-84681 http://purl.obolibrary.org/obo/GO_0046718 denotes viral entry into the host cells
T153 84656-84675 http://purl.obolibrary.org/obo/GO_0044409 denotes entry into the host
T154 86658-86679 http://purl.obolibrary.org/obo/GO_0014863 denotes detection of inactive
T155 96786-96805 http://purl.obolibrary.org/obo/GO_0007165 denotes signal transduction
T156 96793-96805 http://purl.obolibrary.org/obo/GO_0009293 denotes transduction

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T1 0-38 Sentence denotes The Yin and Yang of ACE/ACE2 Pathways:
T2 39-124 Sentence denotes The Rationale for the Use of Renin-Angiotensin System Inhibitors in COVID-19 Patients
T3 126-134 Sentence denotes Abstract
T4 135-342 Sentence denotes The article describes the rationale for inhibition of the renin-angiotensin system (RAS) pathways as specific targets in patients infected by SARS-CoV-2 in order to prevent positive feedback-loop mechanisms.
T5 343-620 Sentence denotes Based purely on experimental studies in which RAS pathway inhibitors were administered in vivo to humans/rodents, a reasonable hypothesis of using inhibitors that block both ACE and ACE2 zinc metalloproteases and their downstream pathways in COVID-19 patients will be proposed.
T6 621-983 Sentence denotes In particular, metal (zinc) chelators and renin inhibitors may work alone or in combination to inhibit the positive feedback loops (initially triggered by SARS-CoV-2 and subsequently sustained by hypoxia independently on viral trigger) as both arms of renin-angiotensin system are upregulated, leading to critical, advanced and untreatable stages of the disease.
T7 985-987 Sentence denotes 1.
T8 988-1000 Sentence denotes Introduction
T9 1001-1178 Sentence denotes The novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is the cause of the COVID-19 pandemic, for which there is currently no specific pharmacotherapy.
T10 1179-1421 Sentence denotes In the intensive care unit, depending on the severity of the COVID-19 infection, patients might receive supportive care such as oxygen supply, interferons, glucocorticoids, anti-virals, chloroquine, and macrolides given as deemed appropriate.
T11 1422-1624 Sentence denotes The SARS-CoV-2 infection produces either non-severe or severe symptoms and, in the latter case, it may precipitate into severe acute respiratory syndrome (SARS) and ultimately death [1,2,3,4,5,6,7,8,9].
T12 1625-1705 Sentence denotes Aging and different comorbidities are associated with patients’ critical status.
T13 1706-1892 Sentence denotes Most patients display lymphopaenia and eosinopaenia, and critical ones show extremely low levels of eosinophils, suggesting that eosinopaenia may be a potential diagnostic biomarker [1].
T14 1893-2148 Sentence denotes Most serious cases of SARS are closely associated with cardiac dysfunction/injury, respiratory distress/illness, coagulopathy, hypoproteinaemia, acidosis, hypoxia and a cytokine storm mainly involving IL-1β, IL-6, IL-8, IL-10 and TNFα [1,2,3,4,5,6,7,8,9].
T15 2149-2622 Sentence denotes For instance, hypertension, an age-related disease, is the most common comorbidity (15–31% up to 24–58% in severe disease cases according to clinical reports), while only five cases of asthma (0.9%) were identified in one report of 548 infected patients in Wuhan [6], but no other asthmatic or allergic patients were described in other reports [1,2,3,4,5,7,8,9], considering that the overall prevalence of asthma is estimated to be 6.4% in Wuhan [6] and ~ 4% in China [10].
T16 2623-2788 Sentence denotes Viral infections usually increase the risk of allergic disease exacerbation [1]; however, the reported data seem to suggest that, in this case, the opposite is true.
T17 2789-3255 Sentence denotes Indeed, in more than 72.000 patient cohorts examined, the number of patients defined as asthmatic was low (5), which suggests that asthmatics might be protected from virus-induced SARS, whereas pre-existing hypertensive disease and/or pre-existing antihypertensive treatments may represent a risk factor for increased virus infection, considering that the overall prevalence of hypertension in Chinese adult population ≥18 years of age is estimated to be ~ 23% [11].
T18 3256-3558 Sentence denotes Therefore, according to the clinical picture of infected patients, Th2-mediated allergic diseases (usually with high eosinophil counts) may play a protective role against SARS (usually with low eosinophil counts), while yet unknown mechanisms related to hypertensive conditions may exacerbate symptoms.
T19 3559-3875 Sentence denotes To complete the picture, COVID-19 hospitalized patients suffering from chronic renal disease were usually low (0-3%) [1,2,3,4,5,6,7,8,9] if compared with the prevalence of the disease in China (10.2-11.3%) [12], suggesting that chronic kidney disease patients might be protected from COVID-19 as for asthma patients.
T20 3877-3879 Sentence denotes 2.
T21 3880-3928 Sentence denotes ACE2-mediated SARS-CoV and SARS-CoV-2 Infections
T22 3929-4092 Sentence denotes Angiotensin-converting enzyme 2 (ACE2) was identified as a receptor for the spike (S) protein of SARS-CoV, finally facilitating viral entry into target cells [13].
T23 4093-4286 Sentence denotes ACE2 is abundantly expressed in airway epithelial cells and vascular endothelial cells, and it is believed to play a crucial role in the mechanism of acute lung injury induced by SARS-CoV [14].
T24 4287-4540 Sentence denotes The ability of spike-Fc protein treatment (3h) to downregulate ACE2 protein expression has been shown in an in vitro system (cell lines) and also in vivo in lung cells of mice [14,15], suggesting that ACE2 pathway may be down-modulated during infection.
T25 4541-4683 Sentence denotes However, ACE2 is constitutively expressed and released from the apical cell surface of human airway epithelia into airway surface liquid [16].
T26 4684-4925 Sentence denotes Of note, its surface down-modulation upon spike protein challenge has been shown to be due to ACE2 shedding mediated by activation of extracellular ADAM17/TACE metalloprotease, which concomitantly induces shedding/production of TNFα [17,18].
T27 4926-5157 Sentence denotes Interestingly, ACE2 shedding is enhanced not only by binding with spike protein [17,18], but also by IL-1β and TNFα inflammatory cytokines [16], cytokines that are secreted at relatively high concentration in COVID-19 patients [2].
T28 5158-5442 Sentence denotes Moreover, soluble (s)ACE2 (induced or not by virus binding) released from human airway epithelia has been demonstrated to retain both its enzymatic activity and its binding ability for spike viral protein, finally reducing spike protein-mediated viral entry into target cells [16,17].
T29 5443-5607 Sentence denotes Therefore, the interaction of ACE2 with spike protein of SARS-CoV induces a cellular “protective” ACE2 shedding feedback response that initially limits viral entry.
T30 5608-5795 Sentence denotes Nevertheless, ADAM17/TACE-mediated ACE2 shedding or ACE2 enzymatic activity have been shown to intriguingly correlate positively with viral infection and disease complications [17,19,20].
T31 5796-5987 Sentence denotes In contrast, HNL63-CoV, which similarly binds to ACE2 through its spike protein, infects ACE2-bearing cells and mainly induces the common cold, leading to neither ACE2 shedding nor SARS [17].
T32 5988-6250 Sentence denotes Moreover, catalytically inactive forms of sACE2 can potently inhibit SARS-CoV infection [19,21], suggesting that events downstream of ACE2 shedding and/or its enzymatic activity may indirectly and subsequently favour viral infection and/or disease complications.
T33 6251-6522 Sentence denotes To this regard, sACE2 was also associated with myocardial pathological conditions [22] and cardiovascular complications including hypotension (known to enhance both renin and angiotensin I, the substrate of ACE/ACE2) and tachycardia were common in SARS-CoV patients [23].
T34 6523-6791 Sentence denotes Since spike protein has been shown to not inhibit ACE2 enzymatic activity that is retained by sACE2-spike protein complex [16,17,24] and, in general, sACE2 maintains its enzymatic activity, we cannot consider its higher circulating expression a mere disease biomarker.
T35 6792-6907 Sentence denotes Indeed, ACE2 shedding might repress its local function but it certainly enhances its circulating/systemic activity.
T36 6908-7236 Sentence denotes Interestingly, a recent integrative bioinformatics analysis shows that the gene expression of ACE2 in human bronchial cells infected with SARS-CoV is dramatically increased 24h after infection and remained at a high level for at least 2 days, suggesting that ACE2 may be involved in a positive feedback loop post-infection [25].
T37 7237-7539 Sentence denotes In the same report, it has been shown that ACE2 expression level in bronchial epithelium obtained by brushing from asthmatic and normal subjects was similar, suggesting that respiratory epithelial cells of healthy subjects and asthmatic patients have similar ability to bind to SARS-CoV-2 through ACE2.
T38 7540-7637 Sentence denotes Of note, ACE2 was also identified as the receptor for the novel spike protein of SARS-CoV-2 [13].
T39 7638-7801 Sentence denotes Although the role of ACE2 in the pathogenesis of SARS-CoV-2 and in inducing lung injury is still unknown, ACE2 behaves similarly to original SARS-CoV [13] (Box 1).
T40 7802-7988 Sentence denotes Box 1 The formation of spike-ACE2 protein complexes may initiate ACE2 systemic upregulation and may impair autologous antibody generation/recognition of anti-S1-Receptor Binding Domain.
T41 7989-8258 Sentence denotes The ACE2 interacts with the spike (S) protein, thereby serves as an entry receptor for SARS-CoVs, and this event is likely followed by conformational changes, cleavages and fusion of both spike viral and ACE2 proteins at the level of infected host cell plasma-membrane.
T42 8259-8444 Sentence denotes The SARS coronavirus surface spike glycoproteins consist of trimers formed by two spike, capsid-distal S1 and –proximal S2, protein regions, located on the outer envelope of the virion.
T43 8445-8701 Sentence denotes Spike proteins are clove-shaped trimers with three S1 heads and a trimeric S2 stalk that can bind the cellular ACE2 receptor when one S1 (possessing the receptor-binding domain) in the trimer adopts an “up” conformation (see Figure later in the Section 4).
T44 8702-9113 Sentence denotes The subsequent binding of ACE2 receptor to the spike glycoprotein triggers both the ADAM17-mediated ACE2 shedding and dissociation of S1 fragments by exogenous (furin-related or other) proteases from the spike trimer, which leads on one hand to one S1-ACE2 complex and two S1 free fragments, and on the other hand to fusion of S2 viral trimers and cellular membrane structures, finally producing cell infection.
T45 9114-9337 Sentence denotes The molecular mechanism model for SARS-CoV recognition and infection was well described by Song and collaborators [26] and a similar molecular interactions between SARS-CoV-2 and ACE2 has been recently hypothesized [27,28].
T46 9338-9530 Sentence denotes To complete the picture, a recent structural work reveals that the full-length human ACE2 is assembled as a dimer associated or not with amino acid transporter B0AT1, which sandwich ACE2 [28].
T47 9531-9668 Sentence denotes Binding of the spike protein trimer onto the ACE2 dimer suggests simultaneous binding of two spike protein trimers to an ACE2 dimer [28].
T48 9669-9937 Sentence denotes Each monomer of the ACE2 homodimer is composed of a membrane-proximal collectrin-like domain mediating homodimerization and necessary to position the molecule to the cell membrane, and of a membrane-distal ACE2 peptidase domain responsible for ACE2 substrate cleavage.
T49 9938-10124 Sentence denotes Collectrin-like domain consists of an extracellular ferredoxin-like fold domain, also called neck domain (residues 616 to 726), a single transmembrane helix and an intracellular segment.
T50 10125-10309 Sentence denotes The ACE2 cleavage site mediated by ADAM17/TACE has been predicted between amino acids 716 and 741 [16], which corresponds to neck-transmembrane boundary of ACE2 collectrin-like domain.
T51 10310-10542 Sentence denotes It is tempting to speculate that, after ACE2 shedding, S2 viral trimers may fuse with the residual ACE2 collectrin-like fragments (complexed or not with B0AT1 transporters) which are eventually exposed on the cell surface membranes.
T52 10543-10647 Sentence denotes A model for SARS-CoV’s internalization by target cells that was already proposed several years ago [29].
T53 10648-10893 Sentence denotes Then, when the virus is inside the cell, a second proteolytic cleavage mediated by endosomal proteases (such as TMPRSS2) in the S2 region of the spike-ACE2 fusion protein might be necessary for intracellular virus “release” and active infection.
T54 10894-11051 Sentence denotes Several S1-sACE2 complexes, free S1 fragments or sACE2 are likely released in bloodstream of COVID-19 infected patients by spike and ACE2 receptor cleavages.
T55 11052-11527 Sentence denotes As already mentioned, circulating sACE2 protein shedding independent on virus contact has been also described either spontaneously when ACE2 transcription is upregulated or upon cytokine activation; it is therefore likely that in the bloodstreams ACE2 proteins are available to bind to both free S1 fragments and SARS-CoV-2 particles, finally leading to more and more S1-sACE2 and SARS-CoV-2-sACE2 complexes bearing enzymatic active sACE2 (see Figure later in the Section 4).
T56 11528-11803 Sentence denotes Of note, SARS-CoV-2-sACE2 complexes, sequestrating sACE2, can drive part of the sACE2 systemic activity and concentrate it locally where the organs possess cells expressing ACE2 on their surface membrane, i.e., following the viral tropism (see Figure later in the Section 4).
T57 11804-12098 Sentence denotes Indeed, although the viral load in sputum of adult SARS-CoV patients was usually higher than 104 copies/mL, reports indicate that plasma viral RNA concentrations are low, usually lower than 190 copies/mL and lymphocytes have much higher RNA-copy concentrations of SARS-CoV RNA than plasma [30].
T58 12099-12244 Sentence denotes Very low RNA concentrations with no difference between patients with mild or severe symptoms were detected in plasma from COVID-19 patients [30].
T59 12245-12376 Sentence denotes The viral load in nasal swabs of asymptomatic and symptomatic COVID-19-positive subjects was also not significantly different [31].
T60 12377-12661 Sentence denotes Of interest, SARS-CoV infected pediatric patients have more than double the amount of plasma RNA copies/mL when compared to adult patients [30], suggesting a different viral tropism between adults and children (different cellular ACE2 expression possibly leading to Kawasaki disease).
T61 12662-12789 Sentence denotes Notably, free S1 fragments may have a decoy function for autologous/exogenous anti-S1-receptor binding domain (RBD) antibodies.
T62 12790-13020 Sentence denotes On the other hand, sACE2-S1 complexes masking S1-RBD might also impair either generation of autologous high affinity antibodies against S1-RBD or recognition/inactivation of S1-RBD on SARS-CoV-2 by autologous/exogenous antibodies.
T63 13021-13393 Sentence denotes Therefore, antibodies that do not compete with ACE2 for the binding to S1-RBD might be more effective in neutralizing SARS-CoV-2 [32,33], knowing that the number of spike proteins per virion is estimated to be around 70 and that every spike protein bears three S1 receptor binding domains, which are masked to autologous antibody recognition when in a “down” conformation.
T64 13394-13589 Sentence denotes These highly organized molecular features clearly demonstrate that the coronaviruses are armed with sophisticated infection machinery able to evade immune responses induced or not by vaccination.
T65 13590-13772 Sentence denotes Nevertheless, passive immunotherapy by means of convalescent plasma from COVID-19 recovered donors is a promising option for prevention and treatment of COVID-19 [32,33,34,35,36,37].
T66 13774-13776 Sentence denotes 3.
T67 13777-13826 Sentence denotes Pathological Effects of ACE2 Pathway Upregulation
T68 13827-13949 Sentence denotes ACE and ACE2 are two zinc metalloproteases involved in the biogenesis of the components of renin-angiotensin system (RAS).
T69 13950-14150 Sentence denotes ACE2 processes angiotensin (Ang) I and II into Ang (1–9) and Ang (1–7), respectively, and it also has other known peptide targets, such as des-Arg(9)-bradykinin, which mediates B1 receptor activation.
T70 14151-14497 Sentence denotes Ang (1–7) and Ang (1–9) peptides, opposing the effects of ACE/Ang II/Ang II type 1 receptor (AT1R) pathway, are known to mediate vasodilatative (hypotension), antiproliferative and apoptotic effects through Mas and AT2 receptors, respectively, both involving downstream nitric oxide synthase (NOS) pathway activation [38,39,40,41,42,43,44,45,46].
T71 14498-14653 Sentence denotes Physiology teaches us that there is a range of normality for every biological parameter, below (defect) and above (excess) of which there is a dysfunction.
T72 14654-14708 Sentence denotes This is likely to be true for ACE as well as for ACE2.
T73 14709-14923 Sentence denotes It is well known that excessive Ang II/AT1R pathway activation induces vasoconstriction, aldosterone, inflammation, excessive cell proliferation, thrombosis, cardiac dysfunction and lung alterations (see Figure 1).
T74 14924-15216 Sentence denotes Moreover, most of the experiments show that increased ACE2 activity leads to beneficial effects; however, the experiments were usually performed using models in which its “antagonist“ (ACE) pathway was upregulated or ACE2 itself was downregulated, therefore balancing an unbalanced situation.
T75 15217-15276 Sentence denotes What does it happen in models in which the opposite occurs?
T76 15277-15488 Sentence denotes (s)ACE2 or Ang (1–7) upregulation have been associated to some pathological conditions such as inflammation of the renal and gastrointestinal tract, cardiac dysfunction, human cirrhosis and lung injury/fibrosis.
T77 15489-15652 Sentence denotes Tissue/organ specific effects of excessive pathway activation that in some case resemble those produced by excessive Ang II/AT1R pathway activation (see Figure 1).
T78 15653-15792 Sentence denotes For example, systemic infusion of Ang (1–7) into mice had renal proinflammatory properties mediated by Mas receptor (MasR) activation [47].
T79 15793-15943 Sentence denotes Moreover, Ang (1–7) infusion was associated with increases in blood pressure, cardiac hypertrophy and fibrosis in rats with subtotal nephrectomy [48].
T80 15944-16124 Sentence denotes Similarly, elevated plasma sACE2 activity was associated both with greater severity of myocardial dysfunction and with an independent prediction of adverse clinical events [22,49].
T81 16125-16385 Sentence denotes Transgenic mice with increased cardiac ACE2 expression suffered from lethal ventricular arrhythmia (heart block, ventricular tachycardia and terminal ventricular fibrillation) consequent upon downregulation of connexins involved in gap junction formation [50].
T82 16386-16534 Sentence denotes In another model, ACE2 transgenic mice suffered from cardiac fibrosis with concomitant deficits in ejection fraction and fractional shortening [51].
T83 16535-16928 Sentence denotes Interestingly, in a rat model of myocardial infarction following coronary artery ligation, there is evidence that C16/MLN-4760 (a specific ACE2 inhibitor, see later) administration inhibits fibrosis and hypertrophy of non-infarcted myocardium and increases diastolic relaxation, raising the possibility that ACE2 activity may have some adverse effects on post-myocardial infarction heart [52].
T84 16929-17067 Sentence denotes The risk factors for cardiovascular disease include alterations in platelet function and coagulation with an increased risk of thrombosis.
T85 17068-17244 Sentence denotes Ang II and hypercholesterolemia are known to participate in microvascular thrombosis and enhanced thrombus formation in the microvasculature may contribute to microinfarctions.
T86 17245-17441 Sentence denotes To this end, in a rat model in which AT1R activation produce baseline thrombosis by platelet aggregation, Ang (1–9), known to bind AT2R [42], has been shown to enhance the thrombotic process [53].
T87 17442-17751 Sentence denotes Moreover, in a mouse model, AT2R activation (inhibited by AT2R antagonist, PD12319) mediated the onset of arteriolar microvascular thrombosis following chronic Ang II infusion [54], indicating both the recruitment of the AT2R pathway downstream of AT1R activation and its involvement in arteriolar thrombosis.
T88 17752-18061 Sentence denotes Of interest, disseminated intravascular coagulation is associated with hypoproteinaemia and deficit of coagulation and anticoagulation proteins, which can originate by their renal loss (and consequent proteinuria) and/or by their increased (pathological) consumption and/or by their reduced hepatic synthesis.
T89 18062-18270 Sentence denotes To this end, in healthy livers, ACE2 is limited to perivenular hepatocytes and endothelial cells; instead, in human hepatitis C cirrhosis, ACE2 protein expression is widespread in the hepatic parenchyma [55].
T90 18271-18462 Sentence denotes Notably, human hepatocytes cultured in hypoxic conditions upregulated ACE2 protein expression [55] and ACE2 mRNA, protein and activity were increased in response to hypoxia and by IL-1β [56].
T91 18463-18666 Sentence denotes In line with these observations, in peripheral blood human CD34+ cells, MasR expression and ACE2 expression, activity and shedding (of sACE2 catalytically active forms) were increased under hypoxia [57].
T92 18667-18924 Sentence denotes Moreover, under hypoxic conditions human pulmonary artery smooth muscle cells upregulated both (arms of the RAS) ACE and ACE2 mRNA and protein expression, and ACE2 was subsequently downregulated by (ACE-derived) Ang II through an AT1R-mediated process [58].
T93 18925-19110 Sentence denotes Similarly, both ACE and ACE2 expression were increased in vascular endothelium and smooth muscle of human left ventricle from patients with ischaemic (local hypoxia) heart disease [59].
T94 19111-19233 Sentence denotes Concomitant upregulation of both arms of the RAS that suggests a tight link between ACE and ACE2 under hypoxic conditions.
T95 19234-19372 Sentence denotes Indeed, several reports have shown a complex interplay of regulation between the two arms of the RAS independently on hypoxia (see Box 2).
T96 19373-19910 Sentence denotes Interestingly, chronic hypoxia induced activation of ACE2/Ang (1–7)/MasR axis and suppression of ACE/Ang II/AT1 receptor axis in lungs of pulmonary hypertensive Ren-2 transgenic rats (constructed by inserting the mouse Ren-2 renin gene) but not in normotensive transgene-negative control rats [60], suggesting that the baseline renin activity in hypertensive rats may be crucial to determine the differential response to hypoxia and that renin inhibition might be useful to inhibit the ACE to ACE2 pathway shift under hypoxic conditions.
T97 19911-20086 Sentence denotes Of interest, hypoxia alone or combined with hypercapnia has been shown to significantly increase both plasma renin expression or activity and plasma Ang II expression [61,62].
T98 20087-20582 Sentence denotes Moreover, hypercapnic acidosis (pH 6.8/6.9, a condition that could occur in SARS) induced in isolated rat lungs has been shown to induce a (compensatory) venular dilatation mediated by cyclooxygenase activation (inhibited by indomethacin) [63], an enzyme that has been shown to be induced downstream of Ang (1–7)/MasR pathway in isolated rat hearts (again inhibited by indomethacin) [64], suggesting the involvement of ACE2/Ang (1–7) pathway in mediating CO2-dependent lung venular vasodilation.
T99 20583-20978 Sentence denotes Altogether these observations indicate that there is a high probability that hypoxia/hypercapnia, a condition that occurs in SARS patients, might upregulate the activity of both arms of the RAS by suppling high amounts of renin product, Ang I, to ACE and ACE2, which, together, can produce high amounts of Ang II, Ang (1–9), Ang (1–7) and its (ACE-produced) metabolite, Ang (1–5) (see Figure 1).
T100 20979-21264 Sentence denotes Similarly to both Ang (1–7)/MasR and Ang (1–9)/AT2R pathways, Ang (1–5) has been shown to induce the secretion of atrial natriuretic peptide via MasR/NOS pathway in isolated perfused rat atria [65], indicating that Ang (1–5) is a heart active peptide (at least in Sprague-Dawley rats).
T101 21265-21431 Sentence denotes Interestingly, in the plasma of patients with inflammatory bowel disease, Ang (1–7) concentrations and (s)ACE2 activity were higher compared to healthy subjects [66].
T102 21432-21585 Sentence denotes Moreover, Ang (1–7) alone can either activate the Bax/Caspase–dependent apoptotic pathway or upregulate NF-kB signaling in lung fibroblast cultures [67].
T103 21586-21859 Sentence denotes Moreover, in vivo administration of Ang (1–7) alone (in Wistar rats) promoted morphological lung alterations, extracellular matrix accumulation and inflammatory cytokine production (including TNF-α and IL-6), characteristics of lung inflammation in pulmonary fibrosis [67].
T104 21860-21957 Sentence denotes Thereby, a condition that deteriorates respiratory compliance, could lead to hypoxia/hypercapnia.
T105 21958-22169 Sentence denotes Hypoxia, in turn, will induce ACE2 upregulation which possibly increases cardiac/lung detrimental effects mediated by Ang (1–7)/MasR pathway activation finally leading to further ACE2 cell membrane upregulation.
T106 22170-22405 Sentence denotes A condition that in COVID-19 can increase the probability of both SARS-CoV-2 entry and ACE2 shedding/systemic activity, finally generating positive feedback loops that might sustain SARS independently of viral infection (see Figure 2).
T107 22406-22723 Sentence denotes This hypothesis is supported by the observations that, in lung aspirates of acid- and/or spike-treated mice, Ang II and ACE2 are synergistically upregulated and cell surface downregulated (shed), respectively, suggesting their involvement in the increased lung microvascular permeability and pulmonary oedema [14,15].
T108 22724-22931 Sentence denotes Indeed, this condition might subsequently favour the diffusion, in neighbouring lung tissues and systemic circulation, of both (s)ACE2, Ang II and Ang (1–7), the Ang II-derived product of (s)ACE2 processing.
T109 22932-23121 Sentence denotes As already proposed, enhanced ACE2 shedding may locally reduce ACE2 activity in lung, however, it likely increases ACE2 systemic activity and subsequent production of circulating Ang (1–7).
T110 23122-23259 Sentence denotes Interestingly, Ang (1–7) has been also reported to promote eosinophil apoptosis in lungs and in bronco-alveolar lavage fluid (BALF) [40].
T111 23260-23531 Sentence denotes Moreover, Ang (1–7)/MasR axis inhibits allergic airway inflammation and eosinophil cell counts in the BALF of a murine model of asthma, indicating both that an impairment of ACE2 pathway may favour asthma and that ACE2 pathway activation can reduces asthma symptoms [68].
T112 23532-23763 Sentence denotes Moreover, a compound that mimics the Ang (1–7) actions has been shown to induce IL-10 upregulation via a MasR-dependent pathway in BALF [69] and IL-10 is thought to mediate anti-inflammatory effects of MasR pathway activation [70].
T113 23764-23884 Sentence denotes IL-10 secretion in mouse plasma was also induced by an AT2 receptor agonist and downstream nitric oxide signalling [71].
T114 23885-24078 Sentence denotes Increased IL-10 production (e.g., by T regulatory cells) is often associated with immune tolerance, which is the consequence of reduced number and function of specific immune compartments [72].
T115 24079-24439 Sentence denotes Indeed, IL-10 has been shown not only to suppress antigen-specific Th2-mediated immune responses including eosinophil expansion in allergic inflammation [72], but also to augment airway reactivity, suggesting that despite its potent anti-inflammatory activity, an excess of IL-10, as well as Ang (1–7), may contribute to the decline in pulmonary function [73].
T116 24440-24752 Sentence denotes Of note, IL-10 is one of the cytokines downstream ACE2 pathway [25] and is significantly upregulated in the most severe forms of COVID-19 [2,8,9], indicating an important correlation between ACE2/Ang (1–7) axis activation and IL-10 upregulation which might lead to eosinopaenia/lymphopaenia in COVID-19 patients.
T117 24753-24824 Sentence denotes Box 2 The reciprocal feedback-loop mechanisms of both arms of the RAS.
T118 24825-25157 Sentence denotes Similarly to hypoxic conditions, a strong correlation between the gene expression of ACE and that of ACE2 was also observed in human renal cortical biopsy specimen, suggesting a link between the two gene transcription, possibly related to the amount/excess of their substrates (Ang I and Ang II) and not exclusively to hypoxia [74].
T119 25158-25518 Sentence denotes A link that tends to maintain the balance of ACE/ACE2 ratio, but that may be disrupted by ACE inhibitors (ACEIs) or by Ang II type 1 receptor blockers (ARBs) which both have been shown to upregulate ACE2 mRNA expression in left ventricle of Lewis rats, possibly through two different mechanisms involving upregulation of Ang (1–7) or Ang II, respectively [75].
T120 25519-25784 Sentence denotes In this regard, in cardiac myocytes isolated from neonatal rats, Ang II significantly reduced ACE2 mRNA and its activity, effects blocked by ARBs, indicating that Ang II downregulates ACE2 expression/activity through an AT1R-dependent mechanism [76] (see Figure 1).
T121 25785-26139 Sentence denotes Moreover, in both cardiac myocytes and rat aortic vascular smooth muscle cells, Ang (1–7) prevented the Ang II-mediated reduction in ACE2 mRNA, an effect blocked by a selective MasR antagonist, D-Ala7-Ang-(1–7) (also known as A779), indicating that Ang (1–7) downregulates Ang II/AT1R signalling through a MasR-dependent mechanism [76,77] (see Figure 1).
T122 26140-26483 Sentence denotes Therefore, Ang (1–7) (as well as ACEIs and ARBs), preventing Ang II-mediated ACE2 downregulation, shift the Ang peptide balance in favour of Ang II metabolisation by ACE2, which, in turn, leads to further production of Ang (1–7), finally sustaining ACE2 transcription, membrane protein expression and eventually shedding and systemic activity.
T123 26484-26695 Sentence denotes Altogether these observations indicate a complex interplay of regulation between the two arms of the RAS in which feedback mechanisms of reciprocal (ACE/ACE2) pathway inhibition are involved at different levels:
T124 26696-26883 Sentence denotes Ang II/AT1 receptor mediates a negative feedback signal on the ACE2 expression/activity and Ang (1–7)/MasR mediated a negative feedback signal on the AT1 receptor activity (see Figure 1).
T125 26884-27114 Sentence denotes These reciprocal inhibitions in some cases (e.g., hypoxia/SARS-CoV-2 infection) can give rise to positive feedback loops that markedly shift the balance between Ang II/AT1R and the antagonist Ang (1–7)/MasR pathway (see Figure 1).
T126 27115-27412 Sentence denotes For example, under hypoxic conditions both arms of the RAS are upregulated and the presence of SARS-CoV-2 can affect Ang (1–7)/Ang II balance (which might be further influenced by ACEI/ARBs) by shifting it in favour of an increased ACE2 systemic activity, Ang (1–7) production and MasR activation.
T127 27413-27628 Sentence denotes This, in turn, can lead to further ACE2 cell membrane expression (increasing the probability of viral entry), which, after ACE2 shedding by binding to spike-SARS-CoV-2, ultimately establish a positive feedback loop.
T128 27630-27632 Sentence denotes 4.
T129 27633-27709 Sentence denotes COVID-19 Can Induce RAS-mediated Positive Feedback Loops at Different Levels
T130 27710-27885 Sentence denotes Intriguingly, the binding affinity of ACE2 to SARS-CoV-2 binding domain has been reported to be either equal to or 10- to 20-fold higher than ACE2 binding to SARS-CoV [27,32].
T131 27886-27987 Sentence denotes The affinity of spike protein for ACE2 has been shown to correlate with the severity of disease [24].
T132 27988-28261 Sentence denotes Although SARS-CoV produces more severe respiratory symptoms than NL63-CoV does, both viral receptor binding domains bind to ACE2 with similar affinity [78], indicating that SARS development is not related to the strength of binding affinity and depends on other mechanisms.
T133 28262-28500 Sentence denotes In contrast to SARS-CoV, NL63-CoV did not induce ADAM17/TACE-mediated both ACE2 shedding and TNF-α secretion [17], suggesting that increased cleavability of ACE2 receptor and possibly of S1-S2 boundary may be crucial for disease severity.
T134 28501-28672 Sentence denotes Indeed, the spike glycoprotein of SARS-CoV-2 but not of SARS-CoV, contains a furin-like cleavage site at the S1-S2 boundary which indicates an increased cleavability [13].
T135 28673-28827 Sentence denotes Of note, TNF-α and IL-1β were shown to both be upregulated in SARS-CoV-2 [2] and induce viral-independent ACE2 shedding from epithelial airway cells [16].
T136 28828-29101 Sentence denotes Moreover, viral-independent ACE2 surface release from epithelial cells was not only inducible by cytokines (e.g., TNF-α and IL-1β) but also constitutively and spontaneously produced when ACE2 surface expression was upregulated [16], for example upon IL-1β stimulation [56].
T137 29102-29250 Sentence denotes This suggests that systemic release of proinflammatory cytokines such as TNF-α and IL-1β can mediate an increase of sACE2 and its systemic activity.
T138 29251-29391 Sentence denotes Of note, activation of ADAM17/TACE metalloprotease was induced by SARS-CoV and necessary for efficient infection (and TNF-α secretion) [17].
T139 29392-29653 Sentence denotes Intriguingly, both SARS-CoV infection and concomitant TNF-α secretion were significantly attenuated not only by knock-down of ADAM17/TACE expression by siRNA but also by deletion of the ACE2 cytoplasmic tail which is responsible for ADAM17/TACE activation [17].
T140 29654-29824 Sentence denotes Altogether these observations suggest the possibility that SARS-CoV may induce a positive feedback loop leading to surface expression and shedding of both ACE2 and TNF-α.
T141 29825-30108 Sentence denotes Indeed, upon spike protein binding to ACE2, downstream pathway activation can sustain positive feedback loops at different levels (Figure 2):(1) SARS-CoV can induce IL-1β and TNF-α systemic secretion that can mediate viral-independent surface membrane ACE2 upregulation and shedding.
T142 30109-30290 Sentence denotes Of note, ACE2 shedding, on one hand, protects from viral infection but, on the other hand, increases circulating/systemic active sACE2, leading to its downstream pathway activation.
T143 30291-30662 Sentence denotes (2) Hypoxia in combination or not with hypercapnia can upregulate the activity of both arms of the renin–angiotensin system by inducing renin, ACE and ACE2 synthesis, which can increase expression of Ang I, Ang II, Ang (1–7), Ang (1–9), Ang (1–5) and the inactive metabolite bradykinin (1–7), but also membrane bound ACE2, finally giving more chances to SARS-CoV-2 entry.
T144 30663-30739 Sentence denotes (3) ACE2 can induce vasodilatative hypotensive effects by Ang II catabolism.
T145 30740-30883 Sentence denotes Hypotension can induce again renin and ACE upregulation finally providing further Ang II, as a ACE2 substrate for further Ang (1–7) production.
T146 30884-31199 Sentence denotes (4) Ang (1–7) antiproliferative and apoptotic effects, possibly in part through IL-10, may mediate eosinopaenia and lymphopaenia that, on one hand, reduce inflammatory responses but, on the other hand, impair immune system ability to counter virus infection, finally predisposing the organism to further infections.
T147 31200-31363 Sentence denotes Ang (1–7) immunosuppressive activity, mediated or not by IL-10, may also support the reduced ability to generate an effective immunization to SARS-CoV-2 infection.
T148 31364-31581 Sentence denotes (5) Ang (1–7)/MasR pathway can sustain ACE2 synthesis even in the presence of elevated concentrations of Ang II (such as in hypoxia), by inhibiting Ang II/AT1R-mediated down-modulation of ACE2 activity (see Figure 1).
T149 31582-31755 Sentence denotes (6) Ang (1–7)/MasR pathway can produce cardiac dysfunction and lung alteration leading to systemic hypoxia, which, in turn, upregulates the activity of both arms of the RAS.
T150 31756-32113 Sentence denotes (7) Although the ACE2 catalytic efficiency is 400-fold lower with Ang I than with Ang II [79], high concentration of circulating ACE2 may be able to produce significant increase of Ang (1–9) that, by binding AT2 receptors, can produce arteriolar microvascular thrombosis and local hypoxic conditions finally inducing local upregulation both arms of the RAS.
T151 32114-32461 Sentence denotes Finally, ACE2-loaded SARS-CoV-2 virions and S1-ACE2 complexes may impair both sACE2 proteolytic degradation by blood proteases and its renal excretion, therefore blunting the removal of its systemic enzymatic activity and indicating that circulating viral particles are dangerous even when they are not able to entry into the cells (see Figure 2).
T152 32462-32665 Sentence denotes On the one hand, ACE2 hypertranscription and consequent increase of membrane (m)ACE2 exposure induced by hypoxia/hypotension may facilitate SARS-CoV-2 entry and its lifecycle into mACE2 expressing cells.
T153 32666-32900 Sentence denotes On the other hand, the release of ACE2 from the cell membranes and its subsequent activity in the bloodstream and in local (lung/cardiac) extracellular fluids are likely critical steps in contributing to systemic disease pathogenesis.
T154 32901-33075 Sentence denotes Nevertheless, the same aetiological agent, SARS-CoV-2, can produce a variety of clinical syndromes, which involves several organs in relation to the subject’s predisposition.
T155 33076-33463 Sentence denotes Although in the present work I have supposed that most of the COVID-19 symptoms might derive from Ang (1–7), Ang II and Ang (1–9) peptide upregulation, the involvement of B1 receptor pathway suppression mediated by ACE2 metabolisation of des-Arg(9)-bradykinin to inactive bradykinin (1–7) or other ACE2-downstream peptides such as apelins, casomorphins and dynorphins cannot be rule out.
T156 33464-33646 Sentence denotes Based on the above observations, in order to block the RAS-induced positive feedback loops, different pharmacological targets can be hypothesized and pursued alone or in combination.
T157 33647-33700 Sentence denotes They will be discussed in the next section and Box 3.
T158 33701-33804 Sentence denotes Box 3 Possible targets of therapeutic intervention to inhibit the RAS-induced positive feedback loops.
T159 33805-34078 Sentence denotes Pharmacological inhibition of enzymes involved in both viral entry, such as TMPRSS2 and ADAM17, and the RAS function such as renin, ACE and ACE2 enzymatic activity or their downstream pathways are expected to stop positive feedback loops and their detrimental consequences.
T160 34079-34137 Sentence denotes Inhibition of TMPRSS2 and ADAM17 metalloprotease activity.
T161 34138-34433 Sentence denotes Inhibition of the serine protease TMPRSS2 (necessary for SARS-CoV-2 entry) by a clinically proven protease inhibitor has been recently suggested by Hoffmann and colleagues [13] and inhibition of ADAM17 enzymatic activity has been already proposed about ten years ago by Haga and colleagues [20].
T162 34434-34788 Sentence denotes Indeed, inhibition of ADAM17-mediated ACE2 shedding is expected to increase membrane ACE2 expression and therefore the probability of viral entry; nevertheless, in the early phases of the disease, inhibition of ACE2 circulating activity might be sufficient to inhibit the systemic RAS pathway upregulation and the development of severe forms of COVID-19.
T163 34789-35163 Sentence denotes It is, in fact, possible that maintenance/recovery of correct organismal immune responses, by preventing ACE2-mediated immune suppression, in concert with cellular adaptive immune responses mediated by apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like (APOBEC) systems [80] may anyway work to induce both an effective “immunization” and the viral eradication.
T164 35164-35199 Sentence denotes Inhibition of both arms of the RAS.
T165 35200-35397 Sentence denotes Among the inhibitors of the RAS pathways, different strategy can be pursued involving either ACE2 enzymatic activity or its upstream renin and ACE enzymatic activity or its downstream MasR pathway.
T166 35398-35624 Sentence denotes Inhibition of ACE2, ACE and renin enzymatic activities and their involvement in SARS-CoVs will be extensively discussed in the next sections, instead a brief description of MasR inhibition will be presented in the present Box.
T167 35625-35707 Sentence denotes Mas receptor pathway inhibition and side effects of using Mas receptor inhibitors.
T168 35708-35871 Sentence denotes A779 also known as D-Ala7-Ang-(1–7) and D-Pro7-Ang-(1–7) are two distinct MasR antagonists able to prevent Ang-(1–7)-mediated downstream activation in human cells.
T169 35872-36245 Sentence denotes The existence of several MasR subtypes has been suggested based on the differential capacity of the two MasR blockers to fully inhibit some biological actions of Ang-(1–7) [and perhaps of Ang (1–5), see Figure 1] [39,70]; therefore, differently from ACE2 enzymatic inhibitors, MasR antagonists should be administered in combinations, in order to inhibit ACE2 hyperactivity.
T170 36246-36436 Sentence denotes In human aortic smooth muscle cells, they have been shown to restore NADPH oxidase/NF-kB/iNOS inflammatory pathway induced by Ang II when it is inhibited by Ang (1–7) co-administration [81].
T171 36437-36815 Sentence denotes In mice studies a MasR blocker (A779) administered alone was not associated with systolic blood pressure alterations, and the hypotensive effect produced by rACE2 co-infused with Ang II was unaffected by A779 co-administration, indicating that the hypotensive activity of rACE2 mainly depended on Ang II degradation rather than on increase of Ang (1–7) and MasR activation [82].
T172 36816-37009 Sentence denotes In another report, spontaneously hypertensive rats (SHRs) that received A-779 alone for a total of two weeks did not significantly alter basal blood pressure and urinary protein excretion [83].
T173 37010-37282 Sentence denotes Moreover, in SHRs treated with A-779 in combination with Ang II, renal injury and interstitial infiltration of macrophages and T cells were surprisingly reduced as compared with SHRs treated with Ang II alone, suggesting a safe use of A-779 drug in in vivo infusions [83].
T174 37283-37439 Sentence denotes Another report showed that infusion of A-779 alone for 7 days did not produce a significant effect neither on blood pressure nor on heart rate in SHRs [84].
T175 37440-37656 Sentence denotes In a rat model of cardiac arrhythmia, administration of A-779 alone did not cause any significant alteration in the number of arrhythmic events, confirming that A-779 can be safely delivered to rodents in vivo. [85].
T176 37657-38007 Sentence denotes Although MasR antagonists has been shown to be safe in acute and chronic in vivo studies either with mice or rats, there are no data on administration in humans and the existence of different MasR subtypes in the vasculature require combinations of MasR antagonists to inhibit an excess of ACE2 activity as for example may occur in COVID-19 patients.
T177 38009-38011 Sentence denotes 5.
T178 38012-38097 Sentence denotes Mechanism of Action and Potential Risk of Using RAS Pathway Inhibitors Targeting ACE2
T179 38099-38103 Sentence denotes 5.1.
T180 38104-38133 Sentence denotes ACE2 (and ACE) Hyperactivity:
T181 38134-38164 Sentence denotes Is It a Matter of (Free) Zinc?
T182 38165-38260 Sentence denotes ACE2 and ACE are two zinc metalloprotease that function differently despite their similarities.
T183 38261-38451 Sentence denotes ACE2 is a monocarboxypeptidase (cleaves a C-terminal single amino acid from its substrate), whereas ACE is a dipeptidylpeptidase (releases a C-terminal dipeptide from its substrate) [86,87].
T184 38452-38758 Sentence denotes ACE2 has a substrate preference for hydrolysis between proline and a hydrophobic or basic C-terminal residue [79,86,87] and acts not only on the RAS and bradykinin peptides but also on the C-terminus of the apelin, casomorphin dynorphin peptides [79], possibly inhibiting Apelin-13 hypotensive action [44].
T185 38759-38875 Sentence denotes It is expressed in the heart, kidneys, liver, colon, small intestine, lung, brain and testes [39,44,45,46,76,77,87].
T186 38876-39085 Sentence denotes Among the tissues expressing ACE2 there are cardiomyocytes, endothelium, alveolar type II cells, ciliated airway cells, vascular smooth muscle cells and testicular Leydig cells [14,39,44,45,46,76,77,87,88,89].
T187 39086-39382 Sentence denotes ACE2 is present on the apical surface of epithelial cells of renal tubules, lung alveoli and vascular endothelia, in these last cells the production of Ang (1–7) induces autocrine activation of MasR axis leading to NOS-mediated vasodilation and consequently hypotension [14,44,45,46,86,87,88,89].
T188 39383-39568 Sentence denotes ACE2, as well as ACE, is a zinc metalloprotease that can be inhibited by zinc chelating EDTA and activated by high concentrations of chloride or fluoride anions and zinc cation [79,90].
T189 39569-39633 Sentence denotes Indeed, both enzymes have chloride- and zinc-binding sites [90].
T190 39634-39758 Sentence denotes It is conceivable that these sites are responsible for the anion and zinc activation effect in both homologous enzymes [90].
T191 39759-40017 Sentence denotes However, the presence of chloride ions increases Ang I cleavage by ACE and ACE2 (increasing both Ang II and Ang (1–9)) and decreases Ang II cleavage by ACE2, suggesting that chloride induces specific ACE2 conformational changes in its active site (see [44]).
T192 40018-40188 Sentence denotes To this regard, in plasma samples of COVID–19 patients, chloride range is usually normal or slightly higher (99.6–107.0 mmol/L) than normal values (96.–106.0 mmol/L) [5].
T193 40189-40275 Sentence denotes Unfortunately, I was not able to find plasma zinc concentrations in COVID-19 patients.
T194 40276-40395 Sentence denotes Zinc is involved in several cellular activities and its systemic concentration is tightly regulated by several factors.
T195 40396-40996 Sentence denotes Of interest, the major transporter/reservoir of zinc in plasma is albumin [91], a protein that was detected at significantly low concentrations in SARS-CoV-2 as well as severe adult respiratory distress syndrome (ARDS, a COVID-19-like disease) (usually < 3.5 g/dL, normal range 3.5–5.4) and inflammatory bowel disease (IBD, a disease with increased ACE2 activity) [6,8,66,92] Since most of zinc in plasma is sequestered by albumin, the total amount of plasma zinc mostly depends on albumin concentration and even small changes in albumin’s capacity for zinc binding may have significant consequences.
T196 40997-41219 Sentence denotes To this regard, reduced concentrations of plasma albumin is believed to increase plasma levels of free zinc, while reducing the total plasma zinc concentrations [91], a condition that was observed in ARDS patients [93,94].
T197 41220-41362 Sentence denotes Indeed, albumin can potentially deplete free bioavailable forms of zinc; vice versa, hypoalbuminaemia may increase free zinc levels in plasma.
T198 41363-41498 Sentence denotes Therefore, some ARDS patients with low levels of both total zinc and albumin might have rather higher than lower free zinc levels [93].
T199 41499-41713 Sentence denotes The free zinc concentration, which describes the fraction of zinc that is loosely bound and easily exchangeable, represents the highly bioavailable (and toxic) part of plasma zinc but it is not clinically detected.
T200 41714-41794 Sentence denotes To that end, zinc/albumin ratio might be a surrogate marker of free zinc levels.
T201 41795-41934 Sentence denotes Indeed, only recently it was described a fluorescence-based method for determining the free zinc concentration in human serum samples [95].
T202 41935-42058 Sentence denotes With this method it was shown that free zinc concentration in sera from females was significantly lower than in males [95].
T203 42059-42208 Sentence denotes Moreover, free zinc concentration did correlate neither with total serum concentrations of zinc (or other metal ions such as iron) nor with age [95].
T204 42209-42432 Sentence denotes Notably, increased plasma zinc bioavailability consequent to reduced albumin levels induces zinc import into cells and likely increases the cellular functions associated to cellular zinc concentrations such as ACE and ACE2.
T205 42433-42619 Sentence denotes Indeed, enzymatic activity of both enzymes seems significantly upregulated in ARDS patients as detected by analysis of Ang peptide concentrations in plasma (see Box later in ARDS topic).
T206 42620-42858 Sentence denotes In addition, serum albumin levels in COVID-19 were usually very low (in severe forms is usually < 3.1 g/dL) [6,8], raising the possibility of a negative correlation between albumin concentration in plasma and increase of the RAS activity.
T207 42859-43181 Sentence denotes In line with these hypotheses, both asthmatic/allergic disease patients and chronic kidney disease patients without a history of cardiovascular disease, which are protected from developing COVID-19, showed a significant decrease in both circulating zinc levels and ACE2 activity as compared to normal values [96,97,98,99].
T208 43182-43488 Sentence denotes Interestingly, chronic renal disease patients with low zinc levels had normal concentrations of albumin but higher urinary zinc excretion than healthy controls [97], suggesting that low ACE2 activity in chronic renal diseases (and protection from SARS) might derive from a higher free Zn2+ renal excretion.
T209 43489-43626 Sentence denotes A similar mechanism mediated by a reduction of extracellular levels of free Zn2+ might be hypothesised for asthma patients, as well [98].
T210 43627-43824 Sentence denotes Unfortunately, I could not find information on plasma albumin concentrations for asthma patients; nevertheless, we might suppose that in these patients the albumin concentration is in normal range.
T211 43825-44058 Sentence denotes Intriguingly, inhalation exposure to ZnCl2/ZnO/hexachloroethane (the main ingredients in smoke bombs) induces both elevated plasma levels of zinc and ARDS with clinical pictures that strongly resemble those of COVID-19 [100,101,102].
T212 44059-44294 Sentence denotes Since both ACE2 and ACE enzymes are activated by high concentrations of chloride and zinc ions [79,90], it is possible to hypothesise an activation of both arms of the RAS in ARDS induced by smoke bombs as well as in COVID-19 patients.
T213 44295-44546 Sentence denotes In addition, metal fume fever, a flu-like syndrome caused by inhalation of welding fumes (mainly containing zinc) can be a predictor for the development of respiratory symptoms and welders have an increased pneumonia and cardiovascular risk [103,104].
T214 44547-44819 Sentence denotes In this regard, metal fume fever has been shown to produce fever, fatigue, muscle ache, cough, dyspnea, and an increase of several cytokines including IL-1β, IL-6, IL-8 and TNF-α [103], symptoms and cytokines that have already been described for COVID-19 patients [2,8,9].
T215 44820-45005 Sentence denotes Notably, TNF-α was upregulated early while IL-6 and IL-8 increased later, suggesting a subsequent involvement of these latter cytokines in response to inhalation of welding fumes [103].
T216 45006-45174 Sentence denotes Moreover, elevated levels of zinc have been shown not only to stimulate pro-inflammatory cytokine secretion by monocytes, but also inhibit T cell functions (see [102]).
T217 45175-45537 Sentence denotes Zinc supplementation that has also been proposed for COVID-19 treatment [105,106,107], is able to suppress allogeneic immune response (see [102]) and incubation of blood cells with welding fume particles resulted in a considerable increase not only of pro-inflammatory cytokines (including IL-1β, IL-6, IL-8, TNF-α) but also the tolerogenic cytokine IL-10 [104].
T218 45538-45866 Sentence denotes Similarly, in pulmonary arterial hypertension (PAH) as well as SARS-CoV, both arms of the inflammatory system (namely IL-1β, IL-2, IL-4, IL-6, IL-8, IL-10, IL-12 and TNF-α) have been shown to be upregulated [108,109,110], suggesting a common systemic pathway of activation in welding syndrome, ARDS, PAH and SARS-CoV infections.
T219 45867-46036 Sentence denotes Finally, the correlations between zinc exposure (metal fume) and cytokine storm [103,104] suggests a possible link between free zinc increase and these type of diseases.
T220 46037-46217 Sentence denotes More information on systemic zinc homeostasis and multiorgan effects of elevated levels of extracellular free zinc (such as in subjects inhaling ZnCl2 smoke) is available in Box 4.
T221 46218-46320 Sentence denotes Box 4 Systemic zinc homeostasis and multiorgan effects of elevated levels of extracellular free zinc.
T222 46321-46562 Sentence denotes Zinc absorption occurs throughout the gastrointestinal tract into enterocytes by zinc transporters of the Zrt- and Irt-like protein (ZIP) family that take up Zn2+, but also Cu2+ and Fe2+ ions, both of which can inhibit zinc absorption [111].
T223 46563-46860 Sentence denotes The bioavailability of zinc is affected by several factors among them the amount of zinc in food, its chemical form (from very low availability, e.g., zinc oxide, to comparatively high, e.g., zinc chloride salt) and its binding to other (intestinal absorbed or non-absorbed) food components [111].
T224 46861-47065 Sentence denotes For example, phytates (components present in foods like rice, cereals and corn) and folic acid can form insoluble complexes with zinc that decrease zinc absorption and increase fecal zinc excretion [111].
T225 47066-47302 Sentence denotes On the other hand, Zn2+ can form complexes with most natural amino acids (AA) that for example can come from digested proteins; each Zn2+ can be coordinated with the amine groups and carboxylate anions of two AAs (a molar ratio of 1:2).
T226 47303-47577 Sentence denotes Interestingly, in an in vitro model, the formulation of either ZnCl2 salt or Zn-AA complexes were absorbed by enterocytes and zinc was released on the opposite side of the enterocyte membrane, thus mimicking the intestinal absorption and release into the blood stream [111].
T227 47578-47709 Sentence denotes It is therefore conceivable that zinc chelates of AA, as well as zinc salts, may participate in bioavailability and uptake of zinc.
T228 47710-47996 Sentence denotes The uptake of zinc-AA complexes by AA transporters of human enterocytes suggests that B0AT1 neutral AA transporter associated with ACE2 [28] might also be involved in zinc-AA uptake (a similar mechanism might be supposable for insulin biosynthesis/secretion in pancreatic β cells [91]).
T229 47997-48148 Sentence denotes Indeed, a recycling of zinc-AAs, possibly supplied by membrane bound ACE2 monocarboxypeptidase cleavage, for ACE2 synthesis could be also hypothesised.
T230 48149-48366 Sentence denotes Plasma zinc concentration is mainly regulated through a balance between intestinal absorption and renal excretion involving specific mechanisms sensitive to both dietary zinc availability and its cellular utilization.
T231 48367-48493 Sentence denotes The majority of Zn2+ in blood binds to serum albumin, which represents the major zinc transporter/reservoir protein in plasma.
T232 48494-48753 Sentence denotes On the other hand, labile-bound pool of Zn2+ labile complexes (e.g., of AA) and free Zn2+ are the biologically available forms of zinc for cellular internalization and/or enzymatic activities (0.1–1% of the total zinc in blood plasma under normal conditions).
T233 48754-48937 Sentence denotes Free Zn2+ is subsequently accumulated by endothelial cells and zinc uptake and release by endothelial cells is the crucial step for redistribution of Zn2+ from plasma to tissues [91].
T234 48938-49117 Sentence denotes Zinc is considered a relatively nontoxic metal; however, several data report that excessive free extracellular zinc is toxic and induce apoptosis in different cell types [91,102].
T235 49118-49451 Sentence denotes Plasma excess of free Zn2+ is uptaken by ZIP transporters on the cell surface of each cells in contact with plasma (including immune cells, endothelial cells, neurons and cardiomyocytes), leading to increase of intracellular zinc that can modulate zinc associated cellular functions in both physiological and pathological conditions.
T236 49452-49882 Sentence denotes Indeed, zinc is an important mediator/messenger involved in several cellular activities and the shift of zinc from plasma to cells may be significant for both normal physiological processes including energy metabolism, blood coagulation, and zinc signalling, and a range of disease states, including neurodegenerative and cardiovascular diseases, metabolic syndrome, inflammation, endothelial stress, diabetes and thrombosis [91].
T237 49883-50109 Sentence denotes For example, excess zinc intake has been shown to contribute to both amyloid beta-peptide plaque formation in Alzheimer’s disease and cardiac dysfunction, indicating that free zinc ion may be much more toxic than thought [91].
T238 50110-50386 Sentence denotes It has been reported that Alzheimer and other neurodegenerative disease patients show elevated levels not only of Zn2+ but also of other divalent metals such as Fe2+ and Cu2+ [112], suggesting a possible link between the increase metal ions and saturation of ZIP transporters.
T239 50387-50600 Sentence denotes On the other hand, increased plasma ferritin levels (such as in COVID-19 [2,3,6]) might reduce free Fe2+ and its “competition” with Zn2+ for ZIP transporters, finally increasing cellular zinc uptake and functions.
T240 50601-50740 Sentence denotes To this regard, EDTA metal chelator has been shown to protect from neural cell death and it was tested in neurodegenerative diseases [102].
T241 50741-50923 Sentence denotes Of interest, plasma albumin acts as a transport protein for both metal ions such as zinc and hydrophobic molecules such as free fatty acid (FFA) to allow their systemic distribution.
T242 50924-51105 Sentence denotes Indeed, albumin is well beyond a mere carrier of metal ions and hydrophobic molecules, and by binding of these different molecules mediates their crosstalk and bioavailability [91].
T243 51106-51218 Sentence denotes To this regard, one particularly intriguing allosteric link exists between FFA and zinc binding to albumin [91].
T244 51219-51424 Sentence denotes When FFAs with ten or more carbon atoms bind to albumin causes the release of Zn2+, suggesting a possible link between dyslipidemia and toxic effects mediated by consequent increase of free zinc in plasma.
T245 51425-51613 Sentence denotes For example, endothelial stress and activation and pro-inflammatory action of FFAs may be mediated by their effects on free zinc release from albumin and its consequent efflux from plasma.
T246 51614-51784 Sentence denotes Different studies have suggested a role of albumin to inhibit interaction of free Zn2+ with amyloid beta-peptides and combat plaque formation in Alzheimer’s disease [91].
T247 51785-51898 Sentence denotes Zn2+ has also been shown to promote clot stability by binding to fibrinogen and inhibiting heparin activity [91].
T248 51899-52020 Sentence denotes An evidence that has suggested a possible positive correlation between increased levels of FFAs and thrombotic risk [91].
T249 52021-52250 Sentence denotes In addition, physiological conditions associated with elevated plasma FFAs, such as physical exercise, can also produce an increased plasma level of free zinc and its downstream physiological events (e.g., activation of the RAS).
T250 52251-52419 Sentence denotes On the other hand, reduced concentrations of plasma albumin (such as IBD, ARDS and COVID-19) will induce elevated plasma levels of both free FFAs and bioavailable zinc.
T251 52420-52582 Sentence denotes Intriguingly, ARDS is induced after inhalation exposure to ZnCl2/ZnO/hexachloroethane, the main ingredients in smoke bombs used for crowd dispersal [100,101,102].
T252 52583-52700 Sentence denotes To this regard, soldiers that breathed smoke-bomb fumes have been shown to quickly or slowly develope ARDS [100,101].
T253 52701-52883 Sentence denotes Interestingly, a patient who had the highest level of serum zinc rapidly developed ARDS that leads to death from multiorgan failure (including respiratory and hepatic failure) [100].
T254 52884-53171 Sentence denotes Instead, a slow progressive clinical course was associated with a significant increase of plasma zinc concentration that negatively correlated with pulmonary and liver function [100], finally leading to death for severe respiratory failure three to five weeks after inhalation [100,101].
T255 53172-53272 Sentence denotes At autopsy diffuse microvascular obliteration and marked endothelial cell injury was apparent [101].
T256 53273-53465 Sentence denotes Widespread occlusion of the pulmonary arteries may contribute to the development of acute pulmonary hypertension and extensive interstitial and intra-alveolar fibrosis was also observed [101].
T257 53466-53678 Sentence denotes Other soldiers wearing gas masks, immediately developed severe coughing and dyspnea, and slowly improved their lung function (only twelve months after exposure their lung function tests were nearly normal) [101].
T258 53679-53763 Sentence denotes All clinical conditions that strongly resemble those described in COVID-19 patients.
T259 53765-53769 Sentence denotes 5.2.
T260 53770-53836 Sentence denotes Safety and Efficacy Concerns of MLN4760 and Dx600 ACE2 Inhibitors.
T261 53837-53976 Sentence denotes It is known that the catalytic cleft of ACE2 consists of two peptidase subdomains: one membrane-distal and the other one membrane-proximal.
T262 53977-54097 Sentence denotes Their weak interactions are consistent with the ability to transition from open to the closed ACE2 conformation [28,90].
T263 54098-54373 Sentence denotes Indeed, the two subdomains undergo a large hinge-bending motion in which membrane-proximal subdomain remains almost unchanged, while membrane-distal subdomain moves to close the distance between the two subdomains, mimicking the opening/closing movement of a clam shell [90].
T264 54374-54664 Sentence denotes ACE2 open conformation likely reflects free state of the enzyme available to catch substrates (or inhibitors), then, when the ACE2 receptor binds to a substrate, the membrane-distal subdomain closes around the substrate (or the inhibitor), finally performing the enzymatic activity [24,90].
T265 54665-54845 Sentence denotes Interestingly, in cryo–electron microscopy structures of full-length human ACE2, only the closed/substrate-bound conformation of ACE2 was observed in the spike-ACE2 complexes [28].
T266 54846-55090 Sentence denotes Since human ACE2 is assembled on cell surface as a homodimer [28], binding of the spike protein trimer onto ACE2 dimer suggests simultaneous binding of two spike protein trimers to substrate-bound conformer of ACE2 homodimer on plasma membrane.
T267 55091-55347 Sentence denotes The spike binding sites on ACE2 homodimer are localized above the membrane-distal peptidase subdomain of each ACE2 monomer, nevertheless neither ACE2 shedding nor ACE2 binding to spike proteins have been shown to inhibit ACE2 enzymatic activity [16,17,24].
T268 55348-55615 Sentence denotes On the other hand, the S-protein-binding region of membrane-distal ACE2 subdomain is not significantly perturbed by the receptor conformational changes and maintains the ability to associate with soluble spike proteins independently on open/closed conformations [24].
T269 55616-55818 Sentence denotes Interestingly, an ACE2 specific inhibitor (MLN-4760) has been shown to induce the closed (inhibitor-bound) ACE2 structure [90] and to retain its inhibitory effects on sACE2 bound to spike proteins [24].
T270 55819-56019 Sentence denotes MLN4760 is a potent and selective human ACE2 inhibitor (IC50 = 0.44 nM against soluble human ACE2) whose synthesis produces a racemic mixture of two diastereomers that showed 75:25 ratio for Isomer A:
T271 56020-56129 Sentence denotes Isomer B [113,114] and the purified isomer B is the isomer commercially available from Merck Millipore [114].
T272 56130-56315 Sentence denotes Testing MLN-4760 racemic mixture and its isomers, it was observed a concentration-dependent inhibition of recombinant human (rh)ACE or rhACE2 activities with all three inhibitors [114].
T273 56316-56666 Sentence denotes The isomer B was less selective (near minimal-maximal rhACE inhibition range 10−6M-10−4M) than the racemate or the isomer A (near minimal-maximal rhACE inhibition range 10−6M-10−2M) and less effective (near maximal rhACE2 inhibition at 10−7M) than the racemate or the isomer A (near maximal rhACE2 inhibition at 10−8 M) for rhACE2 versus rhACE [114].
T274 56667-57033 Sentence denotes Moreover, all three inhibitors exerted a significantly higher inhibitory activity against soluble than membrane-bound forms of (m)ACE2 (near maximal mACE2 inhibition at 10−6M), being the isomer B more selective and effective than the racemate or the isomer A for mACE2 vs. mACE expressed on the surface of mononuclear cells (or CD34 hematopoietic progenitors) [114].
T275 57034-57133 Sentence denotes A second ACE2 inhibitor, Dx600, produced similar results to those obtained with the isomer B [114].
T276 57134-57300 Sentence denotes Another study evaluated the inhibitory activity of both MLN-4760 and DX600 (either the linear conformational form or the disulfide bridged cyclic variant) inhibitors.
T277 57301-57512 Sentence denotes In this report, the experiments were performed at pH 6.5 [115], a pH at which rhACE2 proteolysis operates at maximal activity [79] and a condition that resembles hypercapnic acidosis which may occur during SARS.
T278 57513-57849 Sentence denotes MLN-4760 was still able to strongly and specifically inhibit rhACE2 activity (near maximal inhibition at 10−8 M), preventing rhACE2-driven Ang II degradation into Ang (1–7), whereas DX600 (either linear or cyclic variant) inhibits rhACE2 at relatively higher concentration (near maximal inhibition at 10−6 M–10−7 M, respectively) [115].
T279 57850-57994 Sentence denotes Altogether these data indicate that the racemate or the isomer A are more effective in inhibiting soluble forms of ACE2 than isomer B and Dx600.
T280 57995-58348 Sentence denotes Therefore, these inhibitors at opportune (low) concentrations are expected to preferentially reduce systemic sACE2 activity, while preserving the ACE2 activity of (local) membrane-associated forms of ACE2, knowing that catalytic activity of circulating ACE2 was undetectable in human plasma of healthy subjects due to an endogenous ACE2 inhibitor [116].
T281 58349-58704 Sentence denotes Since MLN-4760 inhibitor promotes the closed ACE2 conformation [90] which is the preferential conformer for virus binding [28], MLN-4760 is expected to not prevent viral entry; nevertheless, its inhibitory function on ACE2 pathway might work on the positive feedback loops (above described) that ultimately favour ACE2 membrane expression and viral entry.
T282 58705-58822 Sentence denotes A potential risk factor of inhibiting the Ang II metabolization into Ang 1–7 could be the increase of blood pressure.
T283 58823-59332 Sentence denotes Although ACE2 pathway inhibition might lead to hypertensive effects, treatment with MLN-4760 for 4-5 weeks had no effect on blood pressure when administered 10 mg/kg/day in drinking water in wild type mice [117] nor in male (mRen2)27 transgenic hypertensive rats (administered 30 mg/kg/day subcutaneously via mini-osmotic pumps) [118], suggesting that hypertensive activity mediated by ACE2 inhibition is promptly balanced by compensatory mechanisms either in normal or hypertensive blood pressure conditions.
T284 59333-59538 Sentence denotes In addition, injections of MLN4760 into the nucleus tractus solitarii has been shown to reduce the baroreceptor reflex in rats, suggesting a role for ACE2 in controlling a reflex bradycardia (see [39,44]).
T285 59539-59773 Sentence denotes Finally, chronic inhibition of ACE2 with MLN-4760 led to increase of ACE, albuminuria and glomerular injury in streptozotocin-induced diabetic mice, indicating a possible adverse effect of the inhibitor in a diabetic background [119].
T286 59774-59947 Sentence denotes Extensive experiments have been also performed with DX600, a specific peptide ACE2 inhibitor that exhibited a mixed competitive and non-competitive type of inhibition [120].
T287 59948-60045 Sentence denotes Actually, several reports describing Dx600 inhibitor administration in mice suggest its safe use.
T288 60046-60326 Sentence denotes Of interest, a report described its (safe) use alone (1 mg/kg per day) by nasal inhalation for 3 days in a mouse model of endotoxin-induced lung inflammation [121]; however, this inhibitor is less efficacious than MLN-4760 in inhibiting the soluble forms of human rACE2 [114,115].
T289 60327-60523 Sentence denotes Altogether these reports on administration of ACE2 inhibitors do not reveal significant adverse impacts or mortality in experimental animals, which suggests their safety in chronic administration.
T290 60524-60623 Sentence denotes This was also confirmed in human clinical trials with MLN-4760 (clinical name: ORE1001, see later).
T291 60624-61143 Sentence denotes Of interest, a report showed that on day 28 post-myocardial infarction, adult male Sprague-Dawley rats that had received MLN-4760 (also called C16) 25 mg/mL/day by daily intraperitoneal injection (as a solution of 42 mg/mL in distilled water) tended to have lower left ventricular pulse pressure, mean arterial pressures and left ventricular relaxation time constant-Tau compared to untreated group (see table 2 of the paper) [52], suggesting a possible protective role of ACE2 inhibition in post-myocardial infarction.
T292 61144-61424 Sentence denotes Therefore, MLN-4760 might be helpful not only for COVID-19 but also in targeted therapies for pathologies correlated with an excessive increase of ACE2 activity that may involve heart, lung, liver, colon or other tissues/organs expressing ACE2 such as blood and endothelial cells.
T293 61425-61651 Sentence denotes As an example, GL1001 (old name of MLN-4760) showed to produce an anti-inflammatory activity in a mouse model of colitis [122], highlighting the importance of the yin-yang balance of ACE/ACE2 pathways (“in medio stat virtus”).
T294 61653-61657 Sentence denotes 5.3.
T295 61658-61706 Sentence denotes Safety and Efficacy Concerns of Chelating Agents
T296 61707-61924 Sentence denotes Based on ACE2 mechanism of action, there are alternative ways to inhibit ACE2 (and ACE), for example concentration of cation/anion might also targets of intervention to inhibit the zinc metalloprotease ACE2 (and ACE).
T297 61925-62022 Sentence denotes In this regard, EDTA, a cation chelator, has been shown to be able to inhibit ACE2 activity [79].
T298 62023-62317 Sentence denotes Of interest, EDTA binds with 106- and 102-fold higher affinity to Zn2+ than to Ca2+ and Fe2+, respectively [123], and in plasma, free Ca2+ concentration (1.05–1.30 mmol/L) is “only” about 103-fold higher than free Zn2+ (0.1–2.0 µmol/L), while majority of iron in plasma is bound to transferrin.
T299 62318-62430 Sentence denotes As a consequence, the iron concentration in plasma of healthy subjects is very low on the order of 10−18M [112].
T300 62431-62738 Sentence denotes Among the essential metal ions present in the organisms, the specific affinity of EDTA for systemic Zn2+ in physiologic conditions is highlighted by the evidence that prolonged treatment with CaNa2EDTA results in specific zinc depletion that is believed to mediate the teratogenic effects of the drug [123].
T301 62739-63068 Sentence denotes As already mentioned, zinc is an important mediator/messenger involved in several cellular activities and excess of free zinc has been shown to be toxic (see also Box 4); however, zinc deficiency has also detrimental effects on growth, neuronal development, and immunity, and in severe cases its consequences can be deadly [102].
T302 63069-63261 Sentence denotes For these reasons, treatments with CaNa2EDTA require a careful monitoring of the patient for the therapeutic effects as well as possible complications, so as to titrate the appropriate dosage.
T303 63262-63367 Sentence denotes CaNa2EDTA was approved by FDA in chelation therapy for lowering blood lead levels a long time ago (1953).
T304 63368-63501 Sentence denotes Then, different (commercially available) iron chelating agents, expected to work in chelating zinc ion as well, were approved by FDA.
T305 63502-63635 Sentence denotes Chelation therapy comprises intravenous or oral administration of chelating agents that remove metal ions such as zinc from the body.
T306 63636-63733 Sentence denotes Cells synthesising high amounts of ACE or ACE2 needs of high amounts of bioavailable (free) zinc.
T307 63734-63876 Sentence denotes Therefore, it is conceivable that plasma levels of free zinc may influence not only ACE and ACE2 activities but also their cellular synthesis.
T308 63877-64008 Sentence denotes Indeed, both ACE and ACE2 synthesis might be particularly sensitive to reduction of free zinc levels in case of their upregulation.
T309 64009-64201 Sentence denotes In addition, metal chelating agents, by limiting the availability of free zinc to cells, might have effects on both ACE2/ACE synthesis and conformation (when assembled on the plasma membrane).
T310 64202-64499 Sentence denotes Indeed, the closed conformer of ACE2 homodimer that is the preferential conformation for virus binding [28], needs the presence of both zinc and substrate/inhibitor in the catalytic site [90], suggesting that zinc chelation (differently from MLN-4760) might also inhibit ACE2-mediated viral entry.
T311 64500-64746 Sentence denotes Intriguingly, chloroquine has been shown to specifically enhance zinc uptake and its accumulation/sequestration in the lysosomes [124], raising the possibility that it might work on COVID-19 patients by reducing zinc recycling and zinc functions.
T312 64747-64956 Sentence denotes As already mentioned, free Zn2+ promotes clot stability by binding to fibrinogen (see Box 4 and [91]) and chloroquine has been shown to have an anti-thrombotic activity by inhibiting platelet activation [125].
T313 64957-65337 Sentence denotes To this regard, upon platelet activation the release of Zn2+ store from their secretory granules has been shown to participate to the pro-coagulant activity in platelet-dependent fibrin formation [126], suggesting that an elevated free Zn2+ concentration might occur and contribute to thrombotic predisposition in COVID-19 patients, a phenomenon possibly countered by chloroquine.
T314 65338-65579 Sentence denotes For all of the above reasons, cation chelating agents, administered alone or in combination with other therapies, might be effective to counter COVID-19 infection, in particular when, induced by hypoxia, both arms of the RAS are upregulated.
T315 65580-65627 Sentence denotes A scenario that would deserve an investigation.
T316 65628-65990 Sentence denotes However, some formulations of metal chelating agents carry a black box warning because they may cause serious and fatal renal toxicity and failure, hepatic toxicity and failure, gastrointestinal haemorrhage, arrhythmias, tetany, hypocalcaemia, hypotension, convulsions, respiratory arrest, and agranulocytosis that can lead to serious infections and death [123].
T317 65991-66158 Sentence denotes For the sake of completeness, besides renal toxicity linked to the route of drug excretion, EDTA has been shown to be effective in chronic renal artery diseases [123].
T318 66159-66249 Sentence denotes Finally, for its teratogenic effects, the drug is also contraindicated in pregnancy [123].
T319 66250-66472 Sentence denotes As a result, treatments with metal chelating agents require close patient monitoring, including laboratory tests of renal and hepatic function, and absolute neutrophil count should be monitored before and during treatment.
T320 66473-66544 Sentence denotes Alternative ways of RAS pathway inhibition are also described in Box 5.
T321 66545-66595 Sentence denotes Box 5 Alternative ways of RAS pathway inhibition.
T322 66596-66703 Sentence denotes Of interest, a small cationic inhibitor of ACE2 (but not of ACE) has been detected in plasma samples [116].
T323 66704-66958 Sentence denotes The endogenous inhibitor might play a compensatory fine-control (within a threshold limit) for normal fluctuation of ACE2 protein in plasma and it has been hypothesized to be a basic AA or a small basic peptide able to compete with ACE2 substrates [116].
T324 66959-67066 Sentence denotes I have already mentioned that AA can chelate zinc forming labile zinc complexes of amino acids (see Box 4).
T325 67067-67252 Sentence denotes It is therefore possible that a basic AA or a small basic peptide capable to specifically accommodate into the catalytic site of ACE2, but into that of ACE, could inhibit ACE2 activity.
T326 67253-67417 Sentence denotes Indeed, despite the similarities, ACE and ACE2 possess different substrate specificity that depends on the smaller ACE2 binding pocket compared to that of ACE [90].
T327 67418-67594 Sentence denotes This specific aspect might determine the specificity for a specific basic amino acid or molecule that is able to accommodate into the catalytic pocket of ACE2 and bind to zinc.
T328 67595-67755 Sentence denotes Among the possible endogenous ACE2 inhibitors, agmatine, decarboxylated arginine, has a chemical structure that resembles that of an ACE2 inhibitor, NAAE [127].
T329 67756-67932 Sentence denotes NAAE is a small molecule that had demonstrated an anti-SARS-CoV activity, by acting on both ACE2 catalytic activity and ACE2 binding domain for spike protein of SARS-CoV [127].
T330 67933-67981 Sentence denotes Unfortunately, NAAE has never been used in vivo.
T331 67982-68272 Sentence denotes Indeed, NAAE is a weak ACE2 inhibitor, it is in fact more than a thousand-fold less potent than MLN-4760; however, if agmatine will be proven to have ACE2 inhibitory activity, it might be helpful to prevent the trigger of the positive feedback loops in the first mild phases of the disease.
T332 68273-68395 Sentence denotes Indeed, it has an important role in down-regulating NO synthesis reducing NO overproduction by different mechanisms [128].
T333 68396-68557 Sentence denotes Of note, NOS pathway has been shown to be upregulated by both Ang (1–7)/MasR and Ang (1–9)/AT2 receptor pathways that are downstream ACE2 activity [38,39,41,43].
T334 68558-68749 Sentence denotes Moreover, agmatine has a regulated plasma concentration in the range of 20-80 ng/mL and the use of dietary agmatine has been shown to be safe and effective in reducing neuropathic pain [129].
T335 68750-68825 Sentence denotes Moreover, agmatine sulfate is regularly taken as a bodybuilding supplement.
T336 68826-69036 Sentence denotes Among natural metal-chelating agents, phytates and folic acid are two chelating agents from vegetables that might reduce zinc intestinal absorption and possibly its systemic concentration (see Box 4 and [111]).
T337 69037-69189 Sentence denotes Similarly, nicotianamine that is extracted from plants (soybean) is a low-molecular weight metal chelator with high affinity for divalent metal cations.
T338 69190-69293 Sentence denotes Nicotianamine has been shown to inhibit the activity of both zinc metalloproteases, ACE2 and ACE [130].
T339 69294-69375 Sentence denotes In addition, zeolites might also be effective in reducing free zinc availability.
T340 69376-69504 Sentence denotes Zeolites are a group of aluminosilicate minerals with crystalline microporous structure that are originated from volcanic rocks.
T341 69505-69676 Sentence denotes Their molecular structure generates cavities that allow high absorbency capacity for a wide range of charged elements such as water, heavy metals, cations and many toxins.
T342 69677-69777 Sentence denotes Clinoptilolite is one of the zeolites that has been widely studied in veterinary and human medicine.
T343 69778-69964 Sentence denotes The increased usage of clinoptilolite-based products in vivo has stimulated several investigations on its safety and its positive medical effects related to human health (see [131,132]).
T344 69965-70102 Sentence denotes Finally, soluble and catalytically inactive forms of ACE2 have been shown to be potent inhibitors of SARS-CoV infection products [19,21].
T345 70103-70203 Sentence denotes An approach that could be pursued (in combination with other therapies) to inhibit SARS-CoV-2 entry.
T346 70204-70420 Sentence denotes Indeed, soluble forms of ACE2 are expected to protect from viral infection and a similar strategy using a recombinant form of human ACE2 has been proposed not only in COVID-19, but also in ARDS and PAH [108,133,134].
T347 70421-70551 Sentence denotes However, it is possible that catalytic active form of ACE2 might favour adverse effects in these specific pathological conditions.
T348 70552-70862 Sentence denotes To this regard, a clinical trial using recombinant hACE2 protein has been recently started (ClinicalTrials.gov number, NCT04287686) in COVID-19 patients and pilot clinical trials of rhACE2 in ARDS and PAH started in 2017 and 2018, respectively [108,134]; unfortunately, no conclusive results are available yet.
T349 70864-70866 Sentence denotes 6.
T350 70867-70980 Sentence denotes Correlation of Pre-existing Circulating ACE2 Activity and Increased Potential to Develop Severe Forms of COVID-19
T351 70981-71124 Sentence denotes Severe symptoms of COVID-19 have been described to correlate with pre-existing hypertension, diabetes, age and male gender [1,2,3,4,5,6,7,8,9].
T352 71125-71502 Sentence denotes It is not still clear whether it depends on constitutive hypertensive conditions and/or on anti-hypertensive treatments or on other age-related conditions, considering that the prevalence of hypertension in Chinese adults is ~ 23% and that only about 41% take prescribed antihypertensive medications, being calcium channel blockers the most commonly used (~ 50%) in China [11].
T353 71503-71741 Sentence denotes To this regard, there is an interesting report describing sACE2 activity in plasma samples of Spanish healthy subjects and patients, in which a total of 2572 subjects from a multicenter study (NEFRONA project, 2009–2011) was studied [96].
T354 71742-71860 Sentence denotes The report shows that male and advanced age were identified as independent predictors of enhanced sACE2 activity [96].
T355 71861-72052 Sentence denotes Furthermore, subjects with hypertension, diabetes, dyslipidemia, or plaques also had significantly increased circulating ACE2 activity when compared with those without these pathologies [96].
T356 72053-72268 Sentence denotes Notably, hypertensive (the most frequent comorbidity with COVID-19) and diabetic patients are often treated with ACE inhibitors (ACEIs) and/or with ARBs, suggesting a possible positive correlation [135,136,137,138].
T357 72269-72554 Sentence denotes Interestingly, circulating ACE2 activity is significantly increased in subjects on therapy with ARBs or taking oral antidiabetic agents as compared with non-treated patients, while treatment with ACEIs and cholecalciferol had no significant influence on circulating ACE2 activity [96].
T358 72555-72710 Sentence denotes In line with this observations, losartan (an ARB), but not lisinopril (an ACEI), was able to upregulate ACE2 activity in left ventricle of Lewis rats [75].
T359 72711-73020 Sentence denotes Nevertheless, plasma concentration of Ang (1–7) was significantly increased with both treatments when compared to vehicle-treated rats and it was significantly higher in ACEI-treated than ARB-treated rats [75], suggesting that ACE inhibition is able to induce an activation of the ACE2/Ang (1–7)/MasR pathway.
T360 73021-73192 Sentence denotes Although more evidence is needed in humans, the above observations suggest that ARBs should be precautionarily avoided to reduce possible ACE2-mediated viral consequences.
T361 73193-73366 Sentence denotes Indeed, under hypoxic conditions, either an ACEI or an ARB have been shown to upregulate membrane ACE2 protein expression on human pulmonary artery smooth muscle cells [58].
T362 73367-73518 Sentence denotes ACEI and ARB have been shown to work by reducing the concentration of Ang II and by inhibiting its AT1-mediated ACE2 downregulation, respectively [58].
T363 73519-73774 Sentence denotes ACEIs and ARBs might therefore play a role in the upregulation of membrane ACE2 expression under hypoxic conditions such as COVID-19, knowing that the increase of membrane bound ACE2 (before its shedding) will also increase the probability of viral entry.
T364 73775-73877 Sentence denotes Of note, ACEI and ARB antihypertensive medications are more commonly used in Europe/USA than in China.
T365 73878-74102 Sentence denotes Nevertheless, recent reports show that the use of ACEI/ARB medications in patients with COVID-19 is safe and ACEI/ARB exposure was not associated with a higher risk of having severe forms of COVID-19 [6,139,140,141,142,143].
T366 74103-74345 Sentence denotes Moreover, some reports show that ACEI/ARB treated patients may even be protected from COVID-19 and ACEI/ARB exposure was associated with a lower risk of mortality compared to those on non-ACEI/ARB antihypertensive drugs [144,145,146,147,148].
T367 74346-74546 Sentence denotes Among these reports, one indicates that the risk of severe symptoms of COVID-19 was significantly decreased in patients who took ARB drugs (but not ACEIs) compared to patients who took no drugs [144].
T368 74547-74773 Sentence denotes Differently, another report suggests that the use of ACEIs (but not ARBs) reduced risk of death and/or critical disease [146], suggesting that some of these reports did not adjust for confounders and further analyses are need.
T369 74774-74972 Sentence denotes Nevertheless, clinical trials of losartan as a treatment for COVID-19, are actually underway among patients who have not previously been treated with ARBs and/or ACEIs (NCT04312009 and NCT04311177).
T370 74973-75222 Sentence denotes However, most of hypertensive/diabetic patients are ACEI- or ARB-“pretreated”, nevertheless they have an increased risk to develop SARS, therefore ACEIs and ARBs, if not detrimental, are not expected to face the disease in non-hypertensive patients.
T371 75223-75554 Sentence denotes A possible beneficial effect of ACEIs in COVID-19 patients could indirectly come by reducing ACE2 substrate, Ang II, and finally limiting Ang (1–7) [but not Ang (1–9)] production and its (detrimental) effects; however, this is only a hypothetical possibility since, in this case, the ACE2/ACE pathway might be even more unbalanced.
T372 75555-75747 Sentence denotes To complete the picture, smokers and subjects on therapy with insulin tend to have an increased (although not significantly) circulating ACE2 activity when compared with control subjects [96].
T373 75748-76009 Sentence denotes On the other hand, increased ACE2 protein expression was reported in plasma and/or urine of physically active men after acute aerobic training or in renal cortices of spontaneous hypertensive, but not normotensive, rats after chronic aerobic training [149,150].
T374 76010-76239 Sentence denotes In addition, recent works reveal that asthma and other allergic diseases, which protect from developing COVID-19, were associated with significant reductions in levels of both zinc in plasma and ACE2 mRNA in airway cells [98,99].
T375 76240-76498 Sentence denotes On the other hand, as already mentioned, some patients with cardiovascular diseases (and inflammatory bowel disease) have an increased circulating ACE2 [22,49,151,152], which might explain the higher probability of elderly heart patients to develop COVID-19.
T376 76499-76728 Sentence denotes Interestingly, in a report on atrial fibrillation, increased plasma ACE2 activity was significantly associated not only with cardiac dysfunction, increasing age, male gender and hypertension, but also with vascular disease [152].
T377 76729-76970 Sentence denotes Altogether the data suggest a strong correlation between circulating ACE2 activity and the predisposition to develop the most severe symptoms of COVID-19, suggesting that circulating sACE2 might be a predictive biomarker of SARS development.
T378 76971-77206 Sentence denotes The surprising aspect is that circulating (differently from membrane bound) ACE2 is expected to protect from viral infection and clinical trials using recombinant ACE2 protein are being pursued (ClinicalTrials.gov number, NCT04287686).
T379 77207-77410 Sentence denotes However, even if it might not be detrimental, recombinant ACE2 is not expected to protect from COVID-19, as circulating ACE2 upregulation correlates with the most common comorbidities in severe COVID-19.
T380 77411-77707 Sentence denotes The correlation is extremely impressive and striking if we also consider the low prevalence of chronic renal disease in COVID-19 hospitalized patients (0–3%) [1,2,3,4,5,6,7,8,9] (prevalence of the disease in China ~11% [12]) which might be protected by a higher sACE2 and/or Zn2+ renal excretion.
T381 77708-77926 Sentence denotes Indeed, in chronic kidney disease patients without a history of cardiovascular disease, there was a significant decrease in circulating ACE2 activity and zinc levels when compared with healthy control subjects [96,97].
T382 77927-78236 Sentence denotes Since proteinuria was associated with lower blood levels of sACE2 protein [153] and chronic kidney disease patients had higher urinary zinc excretion than healthy controls [97], low sACE2 activity in chronic renal diseases and protection from SARS might derive from a higher sACE2 and/or Zn2+ renal excretion.
T383 78237-78483 Sentence denotes Indeed, sACE2 is detectable in urine of healthy subjects and urinary sACE2 protein levels are elevated in patients with chronic renal diseases and in hypertensive patients treated with the Ang II type 1 receptor blocker (ARB) olmesartan [41,154].
T384 78484-78709 Sentence denotes It can, therefore, be supposed that a basal hyperactivity of ACE2 and consequent ACE/ACE2 pathway disequilibrium in blood might predispose to the development of more severe COVID-19 symptoms that involve both arms of the RAS.
T385 78710-79086 Sentence denotes In this regard, different organism predisposition to infections including SARS-CoV-2 or to pathologies associated with an increased risk to develop severe forms of SARS-CoV-2 infection might depend not only on genetic ACE2 polymorphisms and organ-specific ACE2 gene/protein expression [138,155,156,157,158,159,160,161,162,163] but also on anatomical and environmental factors.
T386 79087-79263 Sentence denotes For example, ACE2 gene variants have been associated with risk for hypertension, dyslipidemia, type 2 diabetes and cardiovascular dysfunction [138,155,156,157,158,159,160,161].
T387 79264-79508 Sentence denotes Most of these variants are intronic and located in splice-site junctions or in enhancer regions while the others are placed in the 3’ UTR promoter region, suggesting their involvement in the structure/function and expression of ACE2 gene [138].
T388 79509-79661 Sentence denotes On the other hand, COVID-19 has similar risk factors of obstructive sleep apnea (OSA), suggesting a possible association between OSA and COVID-19 [164].
T389 79662-79828 Sentence denotes Indeed, high prevalence of pre-existing OSA in COVID-19 patients has been reported [165,166], indicating that OSA could be a risk factor for severe forms of Covid-19.
T390 79829-80055 Sentence denotes OSA is characterised by repetitive airway collapse with apnea/hypopnea and intermittent hypoxaemia during sleep and it is associated with hypertension, cardiovascular disease, diabetes, obesity and systemic inflammation [167].
T391 80056-80312 Sentence denotes Most of these diseases are known to predispose to increased levels of circulating ACE2 and, as already mentioned, hypoxia has been shown to upregulate both arms of the RAS; therefore, OSA might predispose to the deleterious effects of SARS-CoV-2 infection.
T392 80313-80553 Sentence denotes In OSA patients, upper airway collapsibility under passive conditions (critical closing pressure) is higher in males than in females due to anatomical factors, i.e., longer upper airways, as upper airway length correlates with OSA severity.
T393 80554-80794 Sentence denotes Indeed, upper airways in females are less collapsible and more stable during sleep than in males [167], suggesting that an anatomical factor might contribute to and result in different gender susceptibility to COVID-19 and disease severity.
T394 80795-80976 Sentence denotes Moreover, diet (e.g., zinc assumption), physical exercise and external temperature and UV radiation are all “environmental” aspects that can seasonally influence the RAS activities.
T395 80977-81090 Sentence denotes Seasonal differences of the RAS activities leading, for example, to differences in blood pressure are well known.
T396 81091-81213 Sentence denotes Of interest, the majority of coronaviruses cause cold-like illnesses and have a relatively low mutational frequency [168].
T397 81214-81287 Sentence denotes Similarly SARS-CoV-2 seems to mutate much slower than seasonal flu [169].
T398 81288-81522 Sentence denotes Nevertheless, like influenza virus, they are responsible for seasonal episodes of common cold in humans worldwide [168], suggesting that coronaviruses may possess an ability to evade immune control that is different from seasonal flu.
T399 81523-81615 Sentence denotes For example, they might favour a relatively short-term activation/memory of immune response.
T400 81616-81752 Sentence denotes Indeed, as for SARS-CoV and MERS-CoV, a short duration of immunity after SARS-CoV-2 infection has been recently suggested [170,171,172].
T401 81753-81933 Sentence denotes Seasonal cold is an annually recurring time period characterized by the prevalence of outbreaks of cold and the season occurs during the cold period of the year in each hemisphere.
T402 81934-82304 Sentence denotes Altogether these observations suggest that seasonal predisposition to some virus infections (including SARS-CoV-2) might not depend only on environmental features that directly inactivate the viruses “unprotected” outside the host (e.g., higher ultraviolet rays and temperatures), but also on seasonal indirect effects produced in the organisms by environmental changes.
T403 82306-82308 Sentence denotes 7.
T404 82309-82418 Sentence denotes Monitoring ACE/ACE2 Activity in COVID-19 in Order to Determine a Rationale Use of the Specific RAS Inhibitors
T405 82419-82526 Sentence denotes There is currently no specific pharmacotherapy to combat SARS-CoV-2 infection and its pathological effects.
T406 82527-82922 Sentence denotes Actually, the use of plasma from convalescent COVID-19 patients or of SARS-CoV-2-specific neutralizing antibodies has been shown to be a promising option for the treatment of critically COVID-19 patients [32,33,34,35,36,37,172,173]; however, it has some limitations that might be overcome by vaccine strategies or by the production of specific anti SARS-Co-V-2 therapeutic monoclonal antibodies.
T407 82923-83099 Sentence denotes Despite the promising data that demonstrate vaccine protection against SARS-CoV-2 in nonhuman primates [174], we cannot be sure to get a vaccine against SARS-CoV-2 (see [175]).
T408 83100-83350 Sentence denotes Indeed, animals immunized with inactivated SARS-CoV vaccines developed a severe (asthma-like) lung eosinophilic immunopathology when challenged with SARS-CoV, further indicating a central role of eosinophil “balanced numbers” in this pathology [176].
T409 83351-83534 Sentence denotes Vaccines might generate antibodies against viral ligand/ACE2 complex that finally blocks ACE2 activity during SARS-CoV infection and consequent downstream asthma-like events/symptoms.
T410 83535-83846 Sentence denotes On the other hand, fatal outcomes in SARS-CoV infection correlated with a cytokine storm involving elevated Th2 serum cytokines (including IL-4, IL-5 and IL-10), suggesting that an increase of Th2 cytokines possibly mediated by virus-specific CD4 T cells might be crucial in the severe forms of infection [110].
T411 83847-84261 Sentence denotes In addition to cytokine profile (such as IL-10), eosinopaenia, tachycardia, normo/hypotension (although COVID-19 and hypoxia increase Ang II and many patients are “hypertensive” and/or receiving anti-hypertensive medications) and hypoxia in SARS-CoV-2 patients are compatible with downstream events stemming from both an excessive ACE2 pathway upregulation and activation of positive feedback loops (see Figure 2).
T412 84262-84458 Sentence denotes ACE2 and (anti-inflammatory) IL-10 hyperproduction may ultimately trigger subsequent compensatory (and deleterious) responses, leading to both renin/ACE and pro-inflammatory cytokine upregulation.
T413 84459-84578 Sentence denotes In line with this hypothesis, a longitudinal study showed that IL-6 increases late during the COVID-19 progression [3].
T414 84579-84875 Sentence denotes Altogether these data imply not only that the ACE2 is the “vehicle” of viral entry into the host cells, but also that virus-dependent and virus-independent mechanisms may sustain activation of both arms of the RAS and of the inflammatory system, finally promoting SARS-induced multi-organ injury.
T415 84876-85186 Sentence denotes Unfortunately, complete analysis of circulating levels of ACE/ACE2 proteins and activities, together with ACE and ACE2 substrates and products i.e., Ang I, Ang 1–9, Ang II, Ang (1–7) and Ang (1–5), des-Arg(9)-bradykinin and the inactive metabolite bradykinin (1–7) is lacking to address the current hypothesis.
T416 85187-85370 Sentence denotes The required data could be obtained from blood sample analyses, however, it is important to consider that:(1) Organ-specific local microenvironment might not reflect the systemic one;
T417 85371-85607 Sentence denotes (2) S1-sACE2 and SARS-CoV-2-sACE2 complexes, formed by viral-induced ACE2 shedding or by subsequent binding of sACE2 with viral particles or S1 fragments in the circulation, might not be detectable by some anti-ACE2 antibodies in ELISA.
T418 85608-85831 Sentence denotes Therefore, since the complexes might prevent/mask sACE2 antibody recognition but not the enzymatic activity, sACE2 detection (and its real concentration) by ELISA in blood samples of COVID-19 patients might not be reliable;
T419 85832-86128 Sentence denotes (3) In order to evaluate circulating ACE/ACE2 activity, we can determine it by adding fluorogenic (RAS) substrates to plasma samples without (thus considering also the endogenous ACE2 inhibitor present in plasma [116]) or with adding ZnCl2, which is able to induce ACE/ACE2 maximal activity [96];
T420 86129-86280 Sentence denotes (4) circulating concentrations ACE/ACE2 substrates/products likely depend on the:(a) level of ACE/ACE2 pathway activity and availability of substrates;
T421 86281-86414 Sentence denotes (b) level of expression of the respective receptors (AT1R, AT2R and MasR) that bind and remove ligand products away from circulation.
T422 86415-86637 Sentence denotes For example, Ang (1–7) concentration in blood by ACE2 pathway upregulation is dependent both on the increase of the (antagonistic) Ang II (and its precursor, Ang I) and on MasR expression on surface of cells in the organs.
T423 86638-86879 Sentence denotes To this regard, the detection of inactive metabolites, such as bradykinin (1–7), in COVID-19 patients and comparison with its concentration in healthy subjects could be the most indicative and reliable markers of ACE2 activity in the plasma.
T424 86880-87283 Sentence denotes Of interest, a report that described the ex vivo effect of human rACE2 on the levels of several endogenous Ang peptides in plasma samples, thus mimicking an acute increase of systemic ACE2 activity in plasma [115] showed a strong reduction of Ang II (as expected), a moderate reduction of Ang I and a significant (more than five-fold) increase of Ang (1–9), Ang (1–7) and (ACE-produced) Ang (1–5) [115].
T425 87284-87406 Sentence denotes Therefore, Ang (1–5) may also be an interesting surrogate marker of ACE-ACE2 combined activity in COVID-19 patients [115].
T426 87407-87927 Sentence denotes At the present time, it has been reported that plasma levels of Ang II in SARS-CoV-2 infected patients are markedly elevated as compared with healthy subjects (interquartile range between 260–360 pg/mL and 65–120 pg/mL, respectively) and linearly associated to viral load and lung injury [177]; unfortunately, nobody has tested the levels of Ang (1–7), Ang (1–9), Ang (1–5) and bradykinin (1–7), some of which might be at high levels as well, thus justifying both normo/hypotension and eosinopaenia in COVID-19 patients.
T427 87928-88111 Sentence denotes More information on the RAS peptides in plasma of Acute Respiratory distress syndrome, a COVID-19-like disease, (and pulmonary arterial hypertension) is instead available (see Box 6).
T428 88112-88195 Sentence denotes Box 6 Acute Respiratory distress syndrome and hyperactivation of the RAS pathways.
T429 88196-88322 Sentence denotes The main clinical feature of ARDS patients is the progressive deterioration of lung function leading to progressive hypoxemia.
T430 88323-88509 Sentence denotes ARDS can be induced by different causes such as ZnCl2 aspiration, sepsis, trauma, acute pancreatitis, or pneumonias following virus infections such as SARS-CoVs or human influenza virus.
T431 88510-88646 Sentence denotes ACE insertion/deletion polymorphisms correlated with severity of ARDS in humans, suggesting that the RAS could have a role in ARDS [44].
T432 88647-88825 Sentence denotes In animal models, ACE2 protected from acute lung by inhibiting Ang II/AT1R activity [15], for this reason the use of recombinant ACE2 in ARDS has been proposed and pursued [134].
T433 88826-89156 Sentence denotes Clinical trials with recombinant human ACE2 started in healthy volunteers in 2009 (ClinicalTrials.gov number, NCT00886353 [178]), then it was tested in ARDS (ClinicalTrials.gov number, NCT01597635 [134]), PAH (ClinicalTrials.gov number, NCT01884051 [108]) and finally in COVID-19 patients (ClinicalTrials.gov number, NCT04287686).
T434 89157-89255 Sentence denotes Despite its safe use, no conclusive evidence in support of its use in these diseases was reported.
T435 89256-89572 Sentence denotes Of interest, in the plasma samples from ARDS patients, levels of Ang I have been shown to be significantly increased in non-survivors (interquartile range 1990–16950 pg/mL) compared to survivors (interquartile range 730–5660 pg/mL) [92], suggesting a marked increase of renin activity in non-surviving ARDS patients.
T436 89573-90027 Sentence denotes Unfortunately, no comparisons of the two ARDS groups with healthy subjects (interquartile range 35–66 pg/mL, markedly lower than both patient groups [179]) were reported; this is important to consider since the plasma concentrations of the RAS peptides may significantly differ depending on method of detection (ELISA versus vs. mass spectrometry) and, in particular, on protocol of determination (endogenous versus equilibrium Ang peptide levels [179]).
T437 90028-90161 Sentence denotes Endogenous RAS peptide concentrations can be evaluated collecting and stabilizing blood samples with a RAS enzyme inhibitor cocktail.
T438 90162-90374 Sentence denotes Differently, heparinized plasma samples can be incubated at 37 °C to induce ex vivo equilibrium, which unveils the presence of renin, ACE and/or ACE2 activity in the plasma (equilibrium Ang peptide levels) [179].
T439 90375-90462 Sentence denotes This last protocol usually gives significantly higher levels of the RAS peptides [179].
T440 90463-90990 Sentence denotes For example, in healthy subjects, the normal ranges (interquartile ranges) of endogenous RAS peptides, Ang I, Ang II, Ang (1–7), Ang (1–9) and Ang (1–5) were 12–24 pg/mL, 1–12 pg/mL, <2 pg/mL, <4 pg/mL and < 1 pg/mL, respectively, differently the normal range after ex vivo equilibrium of the same peptides were 35–66 pg/mL, 110–200 pg/mL, < 2 pg/mL, < 4 pg/mL and < 1 pg/mL, respectively [179], indicating the presence of renin and ACE (but no ACE2) activity (as highlighted by Ang peptide increases upon ex vivo equilibrium).
T441 90991-91193 Sentence denotes Similarly, another report that evaluated Ang II and Ang (1–7) in healthy males showed normal endogenous ranges ~ 14.5 pg/mL and 0.9 pg/mL, respectively, and an Ang (1–7)/Ang II ratio ~ 0.06 ratio [180].
T442 91194-91456 Sentence denotes Moreover, Ang (1–7), Ang I, Ang (1–9) and Ang (1–7)/Ang II ratio were significantly higher in ACEI-treated hypertensive patients compared to healthy subjects [180], suggesting that inhibition of ACE predisposes to upregulation of the ACE2/Ang (1–7)/MasR pathway.
T443 91457-91678 Sentence denotes Notably, two different reports that evaluated the RAS peptides in ARDS patients using the similar method of detection (high performance liquid chromatography plus mass spectrometry) showed significantly different results.
T444 91679-91811 Sentence denotes One report showed that Ang II ranged (interquartile range) between 120–630 pg/mL (non-survivors) and 70–2220 pg/mL (survivors) [92].
T445 91812-92096 Sentence denotes A second report showed significantly lower values of Ang II, (interquartile range) between 40–150 ng/mL (non-survivors with placebo) and 5–20 pg/mL (survivors with placebo) (see Supplementary Data [134]), suggesting that they used different protocols of the RAS peptide determination.
T446 92097-92250 Sentence denotes Nevertheless, both Ang (1–7) and Ang (1–7)/Ang II ratios found in ARDS patients of both reports [92,134] were significantly higher than healthy subjects.
T447 92251-92443 Sentence denotes One report showed that Ang (1–7) ranged (interquartile range) between 2.5–10 pg/mL (see Figure 2B of [134]), Ang II between 5–20 pg/mL (see Figure 2 of [134]) and Ang (1–7)/Ang II ratio ~ 0.5.
T448 92444-92612 Sentence denotes Moreover, in the report in which the elevated concentrations of Ang I and Ang II indicate an ex vivo equilibrium of the RAS peptides, the increase was even more marked.
T449 92613-92931 Sentence denotes In that report, Ang (1–7) (< 1pg/mL in healthy subjects) ranged between 80–1070 pg/mL and Ang (1–7)/Ang II ratio (~ 0.06 in healthy subjects) ranged between 0.24–1.82 [92], suggesting that ACE2 activity (and ACE2 presence in plasma samples) was significantly increased in ARDS patients as compared to healthy subjects.
T450 92932-93113 Sentence denotes In line with this hypothesis, there was the determination of Ang (1–9), whose production from Ang I exclusively depends on ACE2 (which also compete with ACE for the same substrate).
T451 93114-93515 Sentence denotes In normal healthy subjects, it was reproducibly below the limit of quantification [179,180], differently, both in ex vivo treatments of plasma samples with human rACE2 [115,181] and in ARDS patients, it was markedly increased (Ang (1–9) ranged between 100–3080 pg/mL) [92], suggesting both that the dominating activity of ACE in plasma of healthy subjects is overcome by that of ACE2 in ARDS patients.
T452 93516-93593 Sentence denotes Therefore, Ang (1–9) may represent a good surrogate marker for ACE2 activity.
T453 93594-93802 Sentence denotes Similarly to Ang (1–9), there was the determination of Ang (1–5), whose production depend on both ACE2 [that produces Ang (1–7) from Ang II] and ACE [that produces Ang II from I and Ang (1–5) from Ang (1–7)].
T454 93803-94068 Sentence denotes Ang (1–5) was undetectable in healthy subjects [178,179]; however, it was significantly increased in ARDS patients (interquartile range between 50–730 pg/mL [92]), suggesting that both ACE2 and ACE activity were likely upregulated as compared with healthy subjects.
T455 94069-94192 Sentence denotes The activation for both arms of the RAS needs of the contemporary activation renin, the rate-determining enzyme of the RAS.
T456 94193-94523 Sentence denotes Indeed, analysis of plasma samples (from a healthy subjects), treated ex vivo with recombinant renin, showed an increase of Ang I, Ang II, Ang (1–7) and Ang (1–5), but not Ang (1–9) [115,179,181], further suggesting both the ACE2 specific activity in producing Ang (1–9) and an activation of both arms of the RAS in ARDS patients.
T457 94524-94825 Sentence denotes Finally, in vivo or ex vivo administration of human rACE2 in plasma samples produced an increase not only of Ang (1–9) but also of Ang (1–5) and Ang (1–7) in both healthy subjects [178] and ARDS patients [134], indicating that all three Ang peptides might represent surrogate markers of ACE2 activity.
T458 94826-95127 Sentence denotes Of interest, the mean arterial pressure of ARDS patients was markedly low and significantly lower in non–survivors (mean value 65 mmHg and more likely need vasopressor support) compared to survivors (mean value 71 mmHg) [92], which may likely be a consequence of the above described ACE2 upregulation.
T459 95128-95215 Sentence denotes Interestingly, similar features were also detected in PAH and coronary atherosclerosis.
T460 95216-95444 Sentence denotes In particular, a significant increase of both Ang II and Ang (1–7) peptides was observed in plasma of these patients [108,182] and plasma levels of TNF-α were significantly elevated in the critical coronary artery disease [182].
T461 95445-95664 Sentence denotes Moreover, despite a significant increase of Ang II/Ang (1–7) ratio (that suggested a therapeutic use of recombinant hACE2 in PAH patients) systolic and diastolic blood pressures were in the range of normality [108,182].
T462 95665-95875 Sentence denotes Altogether these observations suggest that Ang peptide ratios are not reliable markers for disease status in these pathologies; rather, increased plasma amounts of each RAS peptide should be careful considered.
T463 95877-95879 Sentence denotes 8.
T464 95880-95933 Sentence denotes Hypothesizing Pharmacological Treatments for COVID-19
T465 95934-96044 Sentence denotes Based on the above described hypothesis, inhibition of ACE2 pathway might be beneficial for COVID-19 patients.
T466 96045-96305 Sentence denotes Indeed, the clinical picture as a whole is consistent with an ACE2 gain of function (possibly due to both circulating active forms of S1-sACE2 complexes and local forms of SARS-CoV-2-sACE2 complexes) rather than an ACE2 loss of function, as initially supposed.
T467 96306-96500 Sentence denotes Therefore, inhibition of ACE2/Ang (1–7)/MasR axis or other ACE2 pathways to restore ACE/ACE2 balance might be needed, at least in the first phases of the disease when hypoxia is not yet induced.
T468 96501-96642 Sentence denotes Different strategies could be pursued through ACE2 pathway inhibitors and/or MasR antagonists and/or renin inhibitors and/or metal chelators.
T469 96643-96848 Sentence denotes Several different molecules have been designed to specifically inhibit human ACE2 enzyme (both membrane bound and soluble forms) or human MasR signal transduction, but only a few have been studied in vivo.
T470 96849-96995 Sentence denotes Some ACE2 pathway inhibitors have been widely used in mouse/rat models, as control of human and mouse ACE2 activity or in mouse models of colitis.
T471 96996-97288 Sentence denotes Thanks to mouse/rat in vivo experiments and clinical trial results in human participants it has been possible to infer toxicity/efficacy for some human ACE2 inhibitory molecules (MLN-4760/C16/GL1001/ORE1001, Dx600 and A779) that may be exploited to face this exceptionally dramatic situation.
T472 97289-97539 Sentence denotes Unfortunately, to my knowledge, only one (MLN-4760/C16/GL1001/ORE1001) of the ACE2-specific inhibitors has been tested in vivo in humans in a Phase I clinical trial long time ago (http://oreholdings.com/wp-content/uploads/2013/06/09.02.09-S-4-A.pdf).
T473 97540-97654 Sentence denotes Here, I have focused my attention on inhibitors of human ACE2 pathway that were consistently administered in vivo.
T474 97655-98031 Sentence denotes Making use of published reports in which human/rodent ACE2 pathway inhibitors were administered in vivo, I have hypothesized a possible therapeutic pharmacological intervention through an inhibition strategy of the RAS pathways for COVID-19 in patients experiencing both mild and critical, advanced and untreatable stages of the disease (the most problematic cases to manage).
T475 98033-98037 Sentence denotes 8.1.
T476 98038-98066 Sentence denotes Inhibition of ACE2: MLN-4760
T477 98067-98738 Sentence denotes Briefly, one of the best candidates to treat COVID-19 patients, but not to prevent viral entry, is the small synthetic molecule MLN-4760 (specific ACE2 inhibitor, also known as C16, GL1001 or ORE1001, [113]) for the following reasons:(1) It has been shown to bind/inhibit ACE2 enzymatic activity even at low/acidic pH (pH 6.5, [115]) typical of hypercapnia (as it might occur in lungs of COVID-19 patients) when human ACE2 activity is maximal [79]; nevertheless, it retains its inhibitory effects on soluble ACE2 bound to spike proteins [24], indicating that it is able to bind and inhibit ACE2 activity regardless ACE2 binding to SARS-CoV-2 particles or to S1 fragments.
T478 98739-99143 Sentence denotes (2) No significant adverse effects were described upon its chronic administration neither alone nor in combination with ACE2 activators (while inhibiting their activating effects) nor after inducing functional impairment of ACE2 activity in rodent experiments in vivo [52,117,118,122,183,184] nor in a clinical Phase I trial in humans (http://oreholdings.com/wp-content/uploads/2013/06/09.10.09-425.pdf);
T479 99144-99226 Sentence denotes (3) Its administration by different route is well described in rodents and humans.
T480 99227-99577 Sentence denotes In particular:(a) Chronic administration (about 4 weeks) of C-16/DLM-4760 in combination with ACE2 activating treatments was performed by daily intraperitoneal injection at a dose of 25mg/kg in distilled water (as a solution of 42 mg/mL) or 0.9% sterile saline (as a solution of 84 mg/mL using a 0.5-mL insulin syringe) freshly prepared [52,183,184].
T481 99578-99909 Sentence denotes (b) Alternatively, chronic administration (about 8 days) of GL1001/DLM-4760 disodium salt in combination with an ACE2 activating treatment was performed by subcutaneous injection (5mL/kg) containing up to a dose of 300 mg/kg, twice a day, formulated in a vehicle solution [15% 2-hydroxypropyl-β-cyclodextrin (HPBDC)/85% H2O] [122].
T482 99910-99995 Sentence denotes Subchronic doses of GL1001 indicate no adverse effects up to 1,000 mg/kg (see [122]).
T483 99996-100085 Sentence denotes (c) In humans ORE1001/GL1001/MLN-4760 was already proposed and tested in clinical trials.
T484 100086-100254 Sentence denotes Its pharmaceutical indication was for digestive tract inflammations (Inflammatory bowel disease, gastritis and colitis) that are correlated with overexpression of ACE2.
T485 100255-100331 Sentence denotes In a Phase I clinical testing up 14 days dosing, ORE1001 was well tolerated.
T486 100332-100416 Sentence denotes Subjects received drug (dosing up to 2100 mg) with no side adverse effects reported.
T487 100417-100554 Sentence denotes In particular, 47 subjects received single-dose from 2.1 to 2100 mg and 24 subjects received 14 day multiple doses from 50 mg to 1800 mg.
T488 100555-100644 Sentence denotes All doses were well tolerated, with no significant side effects including blood pressure.
T489 100645-100802 Sentence denotes Pharmacokinetics of orally administered capsules was consistent with once-daily dosing. (http://oreholdings.com/wp-content/uploads/2013/06/09.10.09-425.pdf).
T490 100803-100961 Sentence denotes 300 mg (active drug) oral capsules were used in a Phase Ib/IIa clinical trial that was, however, abandoned. (https://clinicaltrials.gov/ct2/show/NCT01039597).
T491 100962-101111 Sentence denotes (d) Finally, MLN-4760 was also administered (2.5 mg/kg per day) by nasal inhalation for 2–3 days in lung-infected mice by Pseudomonas bacteria [185].
T492 101112-101253 Sentence denotes Interestingly, the report underscores the role played by local concentration of molecules (ACE2) in modulating lung inflammation and disease.
T493 101254-101487 Sentence denotes For these reasons, in diseases involving respiratory tract, like SARS, inhalation treatment is preferable, even for the lower concentration (and hopefully lower toxicity) of MLN-4760 needed for this route of treatment administration.
T494 101488-101603 Sentence denotes Different routes of MLN-4760 treatment administration can be pursued depending on the hospital condition/expertise.
T495 101604-101766 Sentence denotes In this exceptionally critical situation, it could be delivered to critical untreatable patients as a controlled “compassionate use”, in particular by inhalation.
T496 101767-101966 Sentence denotes However, when, under hypoxic conditions, both arms of the RAS are upregulated, it might have a limited action and, by shifting the balance of ACE/ACE2 ratio in favour of ACE, might be even dangerous.
T497 101967-102178 Sentence denotes Instead, specific inhibition of ACE2 enzymatic activity might effectively work in preventing the establishment of positive feedback loops in COVID-19 patients who are suffering from mild symptoms of the disease.
T498 102179-102342 Sentence denotes MLN-4760 is sold by different companies, that, in case it works, could be encouraged to manufacture the molecule, actively contributing to face this global threat.
T499 102343-102490 Sentence denotes On the other hand, the drug could be also synthesized in University chemistry labs because, to my knowledge, is no longer under patent restriction.
T500 102491-102922 Sentence denotes MLN-4760, whose clinical development was abandoned after phase I trials (clinical name, ORE1001), is actually an interesting compound that could be useful for all patients in which a specific ACE2 upregulation is proven and associated to different (heart/lung/liver/intestine/kidney/immune system/blood/coagulation, etc.) pathological conditions related to ACE2 pathway downstream events, as it seems to occur in COVID-19 patients.
T501 102923-103319 Sentence denotes Although in blood of normal subjects sACE2 activity is undetectable because its catalytic activity in human plasma is masked by an endogenous inhibitor [116] and chronic ACE2 activation may be deleterious, some patients might need of sACE2 activity to better face an acute pathological condition, therefore a careful monitoring of clinical parameters should be performed during patient treatment.
T502 103321-103325 Sentence denotes 8.2.
T503 103326-103355 Sentence denotes Inhibition of Renin Activity:
T504 103356-103365 Sentence denotes Aliskiren
T505 103366-103473 Sentence denotes An alternative approach is to inhibit the RAS pathway at its origin by inhibiting renin enzymatic activity.
T506 103474-103687 Sentence denotes Regarding renin inhibitors, aliskiren is the sole compound in this class of drugs that was approved by the US Food and Drug Administration in March 2007 and commercialized for the management of hypertension [186].
T507 103688-103824 Sentence denotes Aliskiren may be used alone or in combination with other drugs to face COVID-19, in particular the severe forms of SARS-CoV-2 infection.
T508 103825-103930 Sentence denotes Indeed, in patients with severe symptoms of COVID-19 hypoxia might have upregulated both arms of the RAS.
T509 103931-104093 Sentence denotes Therefore, aliskiren might be a useful “tool” to reduce production of Ang I, the necessary fuel for both ACE and ACE2 hyperactivity and their detrimental effects.
T510 104094-104310 Sentence denotes Aliskiren treatment in rats has been shown to upregulate both AT1R and MasR expression probably as consequence of a compensation mechanism when both Ang II and Ang (1–7) ligands are reduced by renin inhibition [187].
T511 104311-104531 Sentence denotes Of particular interest in the context of SARS-CoV-2 infection, the treatment has been shown to reduce expression of both AT2R and ACE2, thus possibly performing a multiple action in inhibiting both arms of the RAS [187].
T512 104532-104648 Sentence denotes Similarly, cation chelating agents such as CaNa2EDTA or nicotianamine might also work, although at different levels.
T513 104650-104654 Sentence denotes 8.3.
T514 104655-104672 Sentence denotes Chelating Agents:
T515 104673-104682 Sentence denotes CaNa2EDTA
T516 104683-104961 Sentence denotes As already mentioned, chelating agents, by limiting zinc cellular availability, might influence hyperactivity, synthesis and conformation of both ACE2 and ACE, which may impair not only ACE2 (and ACE) enzymatic activity but also its availability on cell surface for viral entry.
T517 104962-105144 Sentence denotes For these reasons, chelating agents might be effective to counter SARS-CoV-2 infection, and in particular when (e.g., induced by hypoxia) both arms of the RAS are likely upregulated.
T518 105145-105336 Sentence denotes Differently from renin inhibitors, more chelating agents are commercially available and both classes of drugs might be administered, alone or in combination with other therapies for COVID-19.
T519 105337-105627 Sentence denotes Of note, these classes of drugs might be beneficial not only for SARS-CoV-2 infection but also for other disease in which both arms of the RAS (and of the inflammatory system) are upregulated, as for example ARDS, PAH and other pathologies associated to chronic hypoxia and cardiac failure.
T520 105628-105924 Sentence denotes Indeed, both Ang-II and Ang-(1–7) upregulation and a cytokine storm are common aspects in patients not only with ARDS and PAH but also with critical coronary artery disease [182], suggesting an upregulation of both arms of the RAS and of the inflammatory system in several different dysfunctions.
T521 105925-106028 Sentence denotes Notably, a number of clinical trials have indicated the utility of CaNa2EDTA in coronary heart disease.
T522 106029-106148 Sentence denotes It was believed that chelation therapy might alter plaque morphology and volume, or improve endothelial function [123].
T523 106149-106196 Sentence denotes However, the evidence was not convincing [123].
T524 106197-106302 Sentence denotes Future clinical trials on selected patients with both ACE and ACE2 upregulation might be more convincing.
T525 106303-106432 Sentence denotes It is clear that similar pathways of activation can lead to different outcomes depending on individual predisposition/background.
T526 106433-106651 Sentence denotes Therefore, future efforts to understand the genetic, morpho-physiological, environmental and lifestyle factors that individually affect the predisposition to a specific disease with a precision medicine must be pursed.
T527 106652-106823 Sentence denotes To avoid disrupting extracellular calcium levels, CaNa2EDTA formulation is typically employed as an antidote for lead poisoning or as an extracellular zinc chelator [123].
T528 106824-106965 Sentence denotes CaNa2EDTA is poorly absorbed in the gastrointestinal tract therefore can be preferentially administered by parenteral route or by inhalation.
T529 106966-107207 Sentence denotes Nevertheless, oral tablets (e.g., 250–500 mg/tablet) or suppositories of CaNa2EDTA might also work in reducing plasma zinc levels by inhibiting intestinal zinc absorption (the only physiological way of zinc uptake by the organism) [188,189].
T530 107208-107340 Sentence denotes In this regard, eight men showing elevated lead concentrations were given a seven-day course of CaNa2EDTA, 4 g/day in divided doses.
T531 107341-107476 Sentence denotes Oral CaNa2EDTA caused a rise in lead excretion within few hours, suggesting that orally administered drug was partially absorbed [188].
T532 107477-107621 Sentence denotes Importantly, the trial in the eight lead workers demonstrated that oral administration of CaNa2EDTA was safe and produced no side-effects [188].
T533 107622-107892 Sentence denotes However, the FDA-approved method for delivery of CaNa2EDTA in treatment of lead poisoning is intravenously or intramuscularly and the recommended dose for asymptomatic adults and pediatric patients with elevated blood lead levels is 1000 g/m2/day (~0,05 g/kg/day) [190].
T534 107893-108019 Sentence denotes CaNa2EDTA was usually administered for 5–10 days followed by an interval of at least 5–10 days before a second administration.
T535 108020-108078 Sentence denotes Unfortunately, intravenous administration is very painful.
T536 108079-108362 Sentence denotes Administration of CaNa2EDTA via nebulizer has also been pursued for inhalation therapy in pulmonary metal poisonings to protect lung tissue and reduce its systemic uptaken [123]; moreover, nebulized solutions containing EDTA have been proven safe, not inducing adverse effects [191].
T537 108363-108588 Sentence denotes For the sake of completeness, the unconventional methods for administering chelating agents such as rectal or inhalatory administration are not FDA approved methods for delivery and they have not been studied in detail [192].
T538 108589-108739 Sentence denotes CaNa2EDTA diffuses mainly in the extracellular fluids, where it is not significantly metabolized, and it is excreted rapidly by glomerular filtration.
T539 108740-108838 Sentence denotes The chelator has a half-life of 1.4 to 3 h in adults and is completely excreted within 24 h [123].
T540 108839-108920 Sentence denotes For all of the above reasons, CaNa2EDTA might be employed in therapy of COVID-19.
T541 108921-109175 Sentence denotes However, before beginning any therapy with medication, particularly in the case of new diseases (such as COVID-19) or new treatments, a careful patient selection for these new treatments is essential to prevent unnecessary toxicity (“first do not harm”).
T542 109177-109181 Sentence denotes 8.4.
T543 109182-109210 Sentence denotes Safety and Efficacy Concerns
T544 109211-109595 Sentence denotes Unfortunately, diseases of different aetiologies may present similar final dysfunction/alterations (e.g., cardiac dysfunction/lung alterations/thrombosis are induced by excessive activation of either AT1R or MasR/AT2R pathways, see Figure 1), while diseases with same aetiologies may present different final dysfunction/alterations depending on patients (COVID-19 is a clear example).
T545 109596-109808 Sentence denotes This confounding aspect of diseases can lead to erroneous interpretations, and only defining the correct and early molecular origin of diseases is possible to reach a successful outcome if a therapy is available.
T546 109809-110001 Sentence denotes In order to decide who to treat, and when to start treatment, it is important to define the entity of dysfunctions, probability of treatment success and probability to develop adverse effects.
T547 110002-110115 Sentence denotes To promptly intervene in order to prevent severe forms of COVID-19, we need early markers of disease progression.
T548 110116-110512 Sentence denotes To this regard, if plasma (free) Zn2+ (or total zinc/albumin molar ratio), albumin, IL-10, Ang (1–9), Ang (1–7), Ang (1–5) and/or bradykinin (1–7) will be proven to be reliable surrogate markers for ACE and/or ACE2 enzymatic activity in vivo, they could be exploited, together with circulating ACE and ACE2 activity evaluation, in order to decide who and when to start treating COVID-19 patients.
T549 110513-110611 Sentence denotes Alternatively, eosinopaenia and hypotension may be also exploited as signs of disease progression.
T550 110612-111038 Sentence denotes In any case, since the conditions of some patients can be critical, it is highly recommended to administer the minimal effective dose in order to reduce possible side effects, starting with low and increasing doses, while at the same time monitoring patient status and early signs of disease progression (e.g., blood pressure, eosinophil counts, molecular concentrations of the RAS peptides and other markers of inflammation).
T551 111039-111439 Sentence denotes The aim of the project was not necessarily to stop viral entry (the epithelial cells take already care of it shedding ACE2) but to block positive feedback loops that follow the cellular response to SARS-CoV-2 infection, which are likely the main cause of the severe symptoms associated with COVID-19, doing so, the disease might hopefully become like a simple flu, a spontaneously eradicable disease.
T552 111440-111570 Sentence denotes At the moment, I am alone in proposing these new and non-conventional therapeutic approaches that may or may not work on COVID-19.
T553 111571-111756 Sentence denotes In doing so, I have not only described a rationale/strategy to counter COVID-19, but also provided practical information to optimize the RAS inhibitors based on known experimental data.
T554 111757-111946 Sentence denotes Before any in vivo drug administration (e.g., ACE2 inhibitor), it has to be checked the biological activity (e.g., ACE2) that is affected by the drug, considering the possible side effects.
T555 111947-112125 Sentence denotes However, this is not always the case and, in some cases, patients are treated without a careful evaluation of the biological parameter that is modulated by the administered drug.
T556 112126-112338 Sentence denotes In this regard, I have tried to address all aspects of the RAS inhibition in detail because my main concern is that the use of these approaches in a wrong way may lead to a failure or even to deleterious effects.
T557 112339-112582 Sentence denotes That is why I have meticulously described all the steps before possible administration and provided the guideline suggestions and specific recommendations in order to increase the probability of success and to minimize the deleterious effects.
T558 112583-112683 Sentence denotes The readers are, however, expected and encouraged to debate and make their own optimized guidelines.
T559 112685-112700 Sentence denotes Acknowledgments
T560 112701-113042 Sentence denotes I have to thank Josè Enrique O’Connor, Kishore Wary, Claudio Sorio, Nadir Mario Maraldi, Patrizia Pignatti, John Byrnes, Reza Abdi, Genny del Zotto, Gregary Marhefka, Claudio Ortolani, Renato Zambello, Claudio Pioli, Rita Monticelli, Alessandro Minelli, Piero Sestili, Moreno Zamai and Giuliana Benvenuti for their support and encouragement.
T561 113043-113110 Sentence denotes Time was precious, as the virus works 24 h a day and 7 days a week.
T562 113111-113293 Sentence denotes I really hoped that the scientific efforts could become decisive in order to face this dramatic situation and to save people as early and as much as possible but it was not possible.
T563 113294-113399 Sentence denotes With my work, I hope to reach the future generations and tell them that we cannot play with human health.
T564 113400-113509 Sentence denotes I would also like to apologize to those whose relevant contributions could not be cited because of my limits.
T565 113511-113531 Sentence denotes Author Contributions
T566 113532-113574 Sentence denotes L.Z. is sole author and sole investigator.
T567 113575-113624 Sentence denotes The author conceived of the article and wrote it.
T568 113625-113669 Sentence denotes L.Z. read and approved the final manuscript.
T569 113671-113678 Sentence denotes Funding
T570 113679-113722 Sentence denotes This research received no external funding.
T571 113724-113745 Sentence denotes Conflicts of Interest
T572 113746-113800 Sentence denotes The author declares that he has no competing interest.
T573 113802-113984 Sentence denotes Figure 1 Interplay of regulation between the two arms of the renin-angiotensin system and pathophysiological consequences of excessive systemic activation of different RAS pathways.
T574 113985-114149 Sentence denotes Reciprocal (ACE/ACE2) pathway inhibition, RAS inhibitor sites of action and influence of hypoxia/SARS-CoV-2 on the RAS are indicated. (for reference, see the text).
T575 114150-114347 Sentence denotes Figure 2 SARS-CoV-2 induced positive feedback loops mediated by RAS activation and pathophysiological consequences of the systemic excess of circulating ACE2 enzyme. (for reference, see the text).

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T1 817-824 Phenotype denotes hypoxia http://purl.obolibrary.org/obo/HP_0012418
T2 1976-1996 Phenotype denotes respiratory distress http://purl.obolibrary.org/obo/HP_0002098
T3 2006-2018 Phenotype denotes coagulopathy http://purl.obolibrary.org/obo/HP_0003256
T4 2038-2046 Phenotype denotes acidosis http://purl.obolibrary.org/obo/HP_0001941
T5 2048-2055 Phenotype denotes hypoxia http://purl.obolibrary.org/obo/HP_0012418
T6 2062-2076 Phenotype denotes cytokine storm http://purl.obolibrary.org/obo/HP_0033041
T7 2163-2175 Phenotype denotes hypertension http://purl.obolibrary.org/obo/HP_0000822
T8 2334-2340 Phenotype denotes asthma http://purl.obolibrary.org/obo/HP_0002099
T9 2555-2561 Phenotype denotes asthma http://purl.obolibrary.org/obo/HP_0002099
T10 3167-3179 Phenotype denotes hypertension http://purl.obolibrary.org/obo/HP_0000822
T11 3787-3809 Phenotype denotes chronic kidney disease http://purl.obolibrary.org/obo/HP_0012622
T12 3859-3865 Phenotype denotes asthma http://purl.obolibrary.org/obo/HP_0002099
T13 4243-4260 Phenotype denotes acute lung injury http://www.orpha.net/ORDO/Orphanet_178320
T14 6381-6392 Phenotype denotes hypotension http://purl.obolibrary.org/obo/HP_0002615
T15 6472-6483 Phenotype denotes tachycardia http://purl.obolibrary.org/obo/HP_0001649
T16 14296-14307 Phenotype denotes hypotension http://purl.obolibrary.org/obo/HP_0002615
T17 15453-15462 Phenotype denotes cirrhosis http://purl.obolibrary.org/obo/HP_0001394
T18 15842-15869 Phenotype denotes increases in blood pressure http://purl.obolibrary.org/obo/HP_0032263
T19 16201-16223 Phenotype denotes ventricular arrhythmia http://purl.obolibrary.org/obo/HP_0004308
T20 16225-16236 Phenotype denotes heart block http://purl.obolibrary.org/obo/HP_0012722
T21 16238-16261 Phenotype denotes ventricular tachycardia http://purl.obolibrary.org/obo/HP_0004756
T22 16275-16299 Phenotype denotes ventricular fibrillation http://purl.obolibrary.org/obo/HP_0001663
T23 16568-16589 Phenotype denotes myocardial infarction http://purl.obolibrary.org/obo/HP_0001658
T24 16895-16916 Phenotype denotes myocardial infarction http://purl.obolibrary.org/obo/HP_0001658
T25 16950-16972 Phenotype denotes cardiovascular disease http://purl.obolibrary.org/obo/HP_0001626
T26 17079-17099 Phenotype denotes hypercholesterolemia http://purl.obolibrary.org/obo/HP_0003124
T27 17765-17803 Phenotype denotes disseminated intravascular coagulation http://purl.obolibrary.org/obo/HP_0005521
T28 17953-17964 Phenotype denotes proteinuria http://purl.obolibrary.org/obo/HP_0000093
T29 18178-18187 Phenotype denotes hepatitis http://purl.obolibrary.org/obo/HP_0012115
T30 18190-18199 Phenotype denotes cirrhosis http://purl.obolibrary.org/obo/HP_0001394
T31 18436-18443 Phenotype denotes hypoxia http://purl.obolibrary.org/obo/HP_0012418
T32 18653-18660 Phenotype denotes hypoxia http://purl.obolibrary.org/obo/HP_0012418
T33 19082-19089 Phenotype denotes hypoxia http://purl.obolibrary.org/obo/HP_0012418
T34 19352-19359 Phenotype denotes hypoxia http://purl.obolibrary.org/obo/HP_0012418
T35 19396-19403 Phenotype denotes hypoxia http://purl.obolibrary.org/obo/HP_0012418
T36 19794-19801 Phenotype denotes hypoxia http://purl.obolibrary.org/obo/HP_0012418
T37 19924-19931 Phenotype denotes hypoxia http://purl.obolibrary.org/obo/HP_0012418
T38 19955-19966 Phenotype denotes hypercapnia http://purl.obolibrary.org/obo/HP_0012416
T39 20109-20117 Phenotype denotes acidosis http://purl.obolibrary.org/obo/HP_0001941
T40 20660-20667 Phenotype denotes hypoxia http://purl.obolibrary.org/obo/HP_0012418
T41 20668-20679 Phenotype denotes hypercapnia http://purl.obolibrary.org/obo/HP_0012416
T42 21311-21337 Phenotype denotes inflammatory bowel disease http://purl.obolibrary.org/obo/HP_0002037
T43 21835-21853 Phenotype denotes pulmonary fibrosis http://purl.obolibrary.org/obo/HP_0002206
T44 21937-21944 Phenotype denotes hypoxia http://purl.obolibrary.org/obo/HP_0012418
T45 21945-21956 Phenotype denotes hypercapnia http://purl.obolibrary.org/obo/HP_0012416
T46 21958-21965 Phenotype denotes Hypoxia http://purl.obolibrary.org/obo/HP_0012418
T47 22698-22714 Phenotype denotes pulmonary oedema http://purl.obolibrary.org/obo/HP_0100598
T48 23388-23394 Phenotype denotes asthma http://purl.obolibrary.org/obo/HP_0002099
T49 23458-23464 Phenotype denotes asthma http://purl.obolibrary.org/obo/HP_0002099
T50 23510-23516 Phenotype denotes asthma http://purl.obolibrary.org/obo/HP_0002099
T51 25144-25151 Phenotype denotes hypoxia http://purl.obolibrary.org/obo/HP_0012418
T52 26934-26941 Phenotype denotes hypoxia http://purl.obolibrary.org/obo/HP_0012418
T53 30295-30302 Phenotype denotes Hypoxia http://purl.obolibrary.org/obo/HP_0012418
T54 30330-30341 Phenotype denotes hypercapnia http://purl.obolibrary.org/obo/HP_0012416
T55 30740-30751 Phenotype denotes Hypotension http://purl.obolibrary.org/obo/HP_0002615
T56 31488-31495 Phenotype denotes hypoxia http://purl.obolibrary.org/obo/HP_0012418
T57 31681-31688 Phenotype denotes hypoxia http://purl.obolibrary.org/obo/HP_0012418
T58 32567-32574 Phenotype denotes hypoxia http://purl.obolibrary.org/obo/HP_0012418
T59 32575-32586 Phenotype denotes hypotension http://purl.obolibrary.org/obo/HP_0002615
T60 36231-36244 Phenotype denotes hyperactivity http://purl.obolibrary.org/obo/HP_0000752
T61 37458-37476 Phenotype denotes cardiac arrhythmia http://purl.obolibrary.org/obo/HP_0011675
T62 38119-38132 Phenotype denotes Hyperactivity http://purl.obolibrary.org/obo/HP_0000752
T63 39344-39355 Phenotype denotes hypotension http://purl.obolibrary.org/obo/HP_0002615
T64 40578-40598 Phenotype denotes respiratory distress http://purl.obolibrary.org/obo/HP_0002098
T65 40687-40713 Phenotype denotes inflammatory bowel disease http://purl.obolibrary.org/obo/HP_0002037
T66 41305-41321 Phenotype denotes hypoalbuminaemia http://purl.obolibrary.org/obo/HP_0003073
T67 42935-42957 Phenotype denotes chronic kidney disease http://purl.obolibrary.org/obo/HP_0012622
T68 42988-43010 Phenotype denotes cardiovascular disease http://purl.obolibrary.org/obo/HP_0001626
T69 43596-43602 Phenotype denotes asthma http://purl.obolibrary.org/obo/HP_0002099
T70 43708-43714 Phenotype denotes asthma http://purl.obolibrary.org/obo/HP_0002099
T71 44319-44324 Phenotype denotes fever http://purl.obolibrary.org/obo/HP_0001945
T72 44502-44511 Phenotype denotes pneumonia http://purl.obolibrary.org/obo/HP_0002090
T73 44574-44579 Phenotype denotes fever http://purl.obolibrary.org/obo/HP_0001945
T74 44606-44611 Phenotype denotes fever http://purl.obolibrary.org/obo/HP_0001945
T75 44613-44620 Phenotype denotes fatigue http://purl.obolibrary.org/obo/HP_0012378
T76 44622-44633 Phenotype denotes muscle ache http://purl.obolibrary.org/obo/HP_0003326
T77 44635-44640 Phenotype denotes cough http://purl.obolibrary.org/obo/HP_0012735
T78 44642-44649 Phenotype denotes dyspnea http://purl.obolibrary.org/obo/HP_0002094
T79 45552-45583 Phenotype denotes pulmonary arterial hypertension http://purl.obolibrary.org/obo/HP_0002092
T80 45932-45946 Phenotype denotes cytokine storm http://purl.obolibrary.org/obo/HP_0033041
T81 49774-49797 Phenotype denotes cardiovascular diseases http://purl.obolibrary.org/obo/HP_0001626
T82 49993-50012 Phenotype denotes Alzheimer’s disease http://purl.obolibrary.org/obo/HP_0002511
T83 50156-50181 Phenotype denotes neurodegenerative disease http://purl.obolibrary.org/obo/HP_0002180
T84 50406-50431 Phenotype denotes increased plasma ferritin http://purl.obolibrary.org/obo/HP_0003281
T85 50707-50733 Phenotype denotes neurodegenerative diseases http://purl.obolibrary.org/obo/HP_0002180
T86 51338-51350 Phenotype denotes dyslipidemia http://purl.obolibrary.org/obo/HP_0003119
T87 51759-51778 Phenotype denotes Alzheimer’s disease http://purl.obolibrary.org/obo/HP_0002511
T88 52860-52875 Phenotype denotes hepatic failure http://purl.obolibrary.org/obo/HP_0001399
T89 53104-53123 Phenotype denotes respiratory failure http://purl.obolibrary.org/obo/HP_0002878
T90 53373-53385 Phenotype denotes hypertension http://purl.obolibrary.org/obo/HP_0000822
T91 53529-53537 Phenotype denotes coughing http://purl.obolibrary.org/obo/HP_0012735
T92 53542-53549 Phenotype denotes dyspnea http://purl.obolibrary.org/obo/HP_0002094
T93 57475-57483 Phenotype denotes acidosis http://purl.obolibrary.org/obo/HP_0001941
T94 58795-58821 Phenotype denotes increase of blood pressure http://purl.obolibrary.org/obo/HP_0032263
T95 59512-59523 Phenotype denotes bradycardia http://purl.obolibrary.org/obo/HP_0001662
T96 59613-59624 Phenotype denotes albuminuria http://purl.obolibrary.org/obo/HP_0012592
T97 60673-60694 Phenotype denotes myocardial infarction http://purl.obolibrary.org/obo/HP_0001658
T98 61121-61142 Phenotype denotes myocardial infarction http://purl.obolibrary.org/obo/HP_0001658
T99 61538-61545 Phenotype denotes colitis http://purl.obolibrary.org/obo/HP_0002583
T100 65533-65540 Phenotype denotes hypoxia http://purl.obolibrary.org/obo/HP_0012418
T101 65806-65834 Phenotype denotes gastrointestinal haemorrhage http://purl.obolibrary.org/obo/HP_0002239
T102 65836-65847 Phenotype denotes arrhythmias http://purl.obolibrary.org/obo/HP_0011675
T103 65849-65855 Phenotype denotes tetany http://purl.obolibrary.org/obo/HP_0001281
T104 65857-65870 Phenotype denotes hypocalcaemia http://purl.obolibrary.org/obo/HP_0002901
T105 65872-65883 Phenotype denotes hypotension http://purl.obolibrary.org/obo/HP_0002615
T106 65898-65916 Phenotype denotes respiratory arrest http://purl.obolibrary.org/obo/HP_0005943
T107 65922-65937 Phenotype denotes agranulocytosis http://purl.obolibrary.org/obo/HP_0012234
T108 68738-68742 Phenotype denotes pain http://purl.obolibrary.org/obo/HP_0012531
T109 71060-71072 Phenotype denotes hypertension http://purl.obolibrary.org/obo/HP_0000822
T110 71316-71328 Phenotype denotes hypertension http://purl.obolibrary.org/obo/HP_0000822
T111 71888-71900 Phenotype denotes hypertension http://purl.obolibrary.org/obo/HP_0000822
T112 71912-71924 Phenotype denotes dyslipidemia http://purl.obolibrary.org/obo/HP_0003119
T113 76048-76054 Phenotype denotes asthma http://purl.obolibrary.org/obo/HP_0002099
T114 76300-76323 Phenotype denotes cardiovascular diseases http://purl.obolibrary.org/obo/HP_0001626
T115 76329-76355 Phenotype denotes inflammatory bowel disease http://purl.obolibrary.org/obo/HP_0002037
T116 76529-76548 Phenotype denotes atrial fibrillation http://purl.obolibrary.org/obo/HP_0005110
T117 76677-76689 Phenotype denotes hypertension http://purl.obolibrary.org/obo/HP_0000822
T118 77719-77741 Phenotype denotes chronic kidney disease http://purl.obolibrary.org/obo/HP_0012622
T119 77772-77794 Phenotype denotes cardiovascular disease http://purl.obolibrary.org/obo/HP_0001626
T120 77933-77944 Phenotype denotes proteinuria http://purl.obolibrary.org/obo/HP_0000093
T121 78011-78033 Phenotype denotes chronic kidney disease http://purl.obolibrary.org/obo/HP_0012622
T122 78528-78541 Phenotype denotes hyperactivity http://purl.obolibrary.org/obo/HP_0000752
T123 78745-78773 Phenotype denotes predisposition to infections http://purl.obolibrary.org/obo/HP_0002719
T124 79154-79166 Phenotype denotes hypertension http://purl.obolibrary.org/obo/HP_0000822
T125 79168-79180 Phenotype denotes dyslipidemia http://purl.obolibrary.org/obo/HP_0003119
T126 79182-79197 Phenotype denotes type 2 diabetes http://purl.obolibrary.org/obo/HP_0005978
T127 79565-79588 Phenotype denotes obstructive sleep apnea http://purl.obolibrary.org/obo/HP_0002870
T128 79590-79593 Phenotype denotes OSA http://purl.obolibrary.org/obo/HP_0002870
T129 79638-79641 Phenotype denotes OSA http://purl.obolibrary.org/obo/HP_0002870
T130 79702-79705 Phenotype denotes OSA http://purl.obolibrary.org/obo/HP_0002870
T131 79772-79775 Phenotype denotes OSA http://purl.obolibrary.org/obo/HP_0002870
T132 79829-79832 Phenotype denotes OSA http://purl.obolibrary.org/obo/HP_0002870
T133 79885-79890 Phenotype denotes apnea http://purl.obolibrary.org/obo/HP_0002104
T134 79891-79899 Phenotype denotes hypopnea http://purl.obolibrary.org/obo/HP_0040213
T135 79967-79979 Phenotype denotes hypertension http://purl.obolibrary.org/obo/HP_0000822
T136 79981-80003 Phenotype denotes cardiovascular disease http://purl.obolibrary.org/obo/HP_0001626
T137 80015-80022 Phenotype denotes obesity http://purl.obolibrary.org/obo/HP_0001513
T138 80170-80177 Phenotype denotes hypoxia http://purl.obolibrary.org/obo/HP_0012418
T139 80240-80243 Phenotype denotes OSA http://purl.obolibrary.org/obo/HP_0002870
T140 80316-80319 Phenotype denotes OSA http://purl.obolibrary.org/obo/HP_0002870
T141 80540-80543 Phenotype denotes OSA http://purl.obolibrary.org/obo/HP_0002870
T142 83181-83187 Phenotype denotes asthma http://purl.obolibrary.org/obo/HP_0002099
T143 83506-83512 Phenotype denotes asthma http://purl.obolibrary.org/obo/HP_0002099
T144 83609-83623 Phenotype denotes cytokine storm http://purl.obolibrary.org/obo/HP_0033041
T145 83910-83921 Phenotype denotes tachycardia http://purl.obolibrary.org/obo/HP_0001649
T146 83929-83940 Phenotype denotes hypotension http://purl.obolibrary.org/obo/HP_0002615
T147 83964-83971 Phenotype denotes hypoxia http://purl.obolibrary.org/obo/HP_0012418
T148 84077-84084 Phenotype denotes hypoxia http://purl.obolibrary.org/obo/HP_0012418
T149 87877-87888 Phenotype denotes hypotension http://purl.obolibrary.org/obo/HP_0002615
T150 87984-88004 Phenotype denotes Respiratory distress http://purl.obolibrary.org/obo/HP_0002098
T151 88045-88076 Phenotype denotes pulmonary arterial hypertension http://purl.obolibrary.org/obo/HP_0002092
T152 88125-88145 Phenotype denotes Respiratory distress http://purl.obolibrary.org/obo/HP_0002098
T153 88312-88321 Phenotype denotes hypoxemia http://purl.obolibrary.org/obo/HP_0012418
T154 88377-88387 Phenotype denotes aspiration http://purl.obolibrary.org/obo/HP_0002835
T155 88389-88395 Phenotype denotes sepsis http://purl.obolibrary.org/obo/HP_0100806
T156 88405-88423 Phenotype denotes acute pancreatitis http://purl.obolibrary.org/obo/HP_0001735
T157 88428-88438 Phenotype denotes pneumonias http://purl.obolibrary.org/obo/HP_0002090
T158 95190-95214 Phenotype denotes coronary atherosclerosis http://purl.obolibrary.org/obo/HP_0001677
T159 96473-96480 Phenotype denotes hypoxia http://purl.obolibrary.org/obo/HP_0012418
T160 96987-96994 Phenotype denotes colitis http://purl.obolibrary.org/obo/HP_0002583
T161 98412-98423 Phenotype denotes hypercapnia http://purl.obolibrary.org/obo/HP_0012416
T162 100155-100181 Phenotype denotes Inflammatory bowel disease http://purl.obolibrary.org/obo/HP_0002037
T163 100183-100192 Phenotype denotes gastritis http://purl.obolibrary.org/obo/HP_0005263
T164 100197-100204 Phenotype denotes colitis http://purl.obolibrary.org/obo/HP_0002583
T165 103668-103680 Phenotype denotes hypertension http://purl.obolibrary.org/obo/HP_0000822
T166 103878-103885 Phenotype denotes hypoxia http://purl.obolibrary.org/obo/HP_0012418
T167 104049-104062 Phenotype denotes hyperactivity http://purl.obolibrary.org/obo/HP_0000752
T168 104779-104792 Phenotype denotes hyperactivity http://purl.obolibrary.org/obo/HP_0000752
T169 105091-105098 Phenotype denotes hypoxia http://purl.obolibrary.org/obo/HP_0012418
T170 105599-105606 Phenotype denotes hypoxia http://purl.obolibrary.org/obo/HP_0012418
T171 105611-105626 Phenotype denotes cardiac failure http://purl.obolibrary.org/obo/HP_0001635
T172 105681-105695 Phenotype denotes cytokine storm http://purl.obolibrary.org/obo/HP_0033041
T173 110545-110556 Phenotype denotes hypotension http://purl.obolibrary.org/obo/HP_0002615
T174 114074-114081 Phenotype denotes hypoxia http://purl.obolibrary.org/obo/HP_0012418

2_test

Id Subject Object Predicate Lexical cue
32708755-32077115-20678617 1605-1606 32077115 denotes 1
32708755-32161940-20678618 1607-1608 32161940 denotes 2
32708755-32171076-20678619 1609-1610 32171076 denotes 3
32708755-32109013-20678620 1613-1614 32109013 denotes 5
32708755-32294485-20678621 1615-1616 32294485 denotes 6
32708755-32091533-20678622 1617-1618 32091533 denotes 7
32708755-31986264-20678623 1619-1620 31986264 denotes 8
32708755-32297671-20678624 1621-1622 32297671 denotes 9
32708755-32077115-20678625 1889-1890 32077115 denotes 1
32708755-32077115-20678626 2129-2130 32077115 denotes 1
32708755-32161940-20678627 2131-2132 32161940 denotes 2
32708755-32171076-20678628 2133-2134 32171076 denotes 3
32708755-32109013-20678629 2137-2138 32109013 denotes 5
32708755-32294485-20678630 2139-2140 32294485 denotes 6
32708755-32091533-20678631 2141-2142 32091533 denotes 7
32708755-31986264-20678632 2143-2144 31986264 denotes 8
32708755-32297671-20678633 2145-2146 32297671 denotes 9
32708755-32294485-20678634 2413-2414 32294485 denotes 6
32708755-32077115-20678635 2494-2495 32077115 denotes 1
32708755-32161940-20678636 2496-2497 32161940 denotes 2
32708755-32171076-20678637 2498-2499 32171076 denotes 3
32708755-32109013-20678638 2502-2503 32109013 denotes 5
32708755-32091533-20678639 2504-2505 32091533 denotes 7
32708755-31986264-20678640 2506-2507 31986264 denotes 8
32708755-32297671-20678641 2508-2509 32297671 denotes 9
32708755-32294485-20678642 2596-2597 32294485 denotes 6
32708755-31230828-20678643 2618-2620 31230828 denotes 10
32708755-32077115-20678644 2700-2701 32077115 denotes 1
32708755-29449338-20678645 3251-3253 29449338 denotes 11
32708755-32077115-20678646 3677-3678 32077115 denotes 1
32708755-32161940-20678647 3679-3680 32161940 denotes 2
32708755-32171076-20678648 3681-3682 32171076 denotes 3
32708755-32109013-20678649 3685-3686 32109013 denotes 5
32708755-32294485-20678650 3687-3688 32294485 denotes 6
32708755-32091533-20678651 3689-3690 32091533 denotes 7
32708755-31986264-20678652 3691-3692 31986264 denotes 8
32708755-32297671-20678653 3693-3694 32297671 denotes 9
32708755-22386035-20678654 3766-3768 22386035 denotes 12
32708755-32142651-20678655 4088-4090 32142651 denotes 13
32708755-16007097-20678656 4282-4284 16007097 denotes 14
32708755-16007097-20678657 4464-4466 16007097 denotes 14
32708755-16001071-20678658 4467-4469 16001071 denotes 15
32708755-18490652-20678659 4918-4920 18490652 denotes 17
32708755-19864379-20678660 4921-4923 19864379 denotes 18
32708755-18490652-20678661 5007-5009 18490652 denotes 17
32708755-19864379-20678662 5010-5012 19864379 denotes 18
32708755-32161940-20678663 5154-5155 32161940 denotes 2
32708755-18490652-20678664 5438-5440 18490652 denotes 17
32708755-18490652-20678665 5785-5787 18490652 denotes 17
32708755-15367630-20678666 5788-5790 15367630 denotes 19
32708755-19995578-20678667 5791-5793 19995578 denotes 20
32708755-18490652-20678668 5983-5985 18490652 denotes 17
32708755-15367630-20678669 6077-6079 15367630 denotes 19
32708755-16510163-20678670 6080-6082 16510163 denotes 21
32708755-19700132-20678671 6334-6336 19700132 denotes 22
32708755-16461478-20678672 6518-6520 16461478 denotes 23
32708755-18490652-20678673 6649-6651 18490652 denotes 17
32708755-15791205-20678674 6652-6654 15791205 denotes 24
32708755-32142651-20678675 7633-7635 32142651 denotes 13
32708755-32142651-20678676 7789-7791 32142651 denotes 13
32708755-30102747-20678677 9229-9231 30102747 denotes 26
32708755-32075877-20678678 9330-9332 32075877 denotes 27
32708755-32132184-20678679 9333-9335 32132184 denotes 28
32708755-32132184-20678680 9526-9528 32132184 denotes 28
32708755-32132184-20678681 9664-9666 32132184 denotes 28
32708755-17522231-20678682 10643-10645 17522231 denotes 29
32708755-32107119-20678683 12094-12096 32107119 denotes 30
32708755-32107119-20678684 12240-12242 32107119 denotes 30
32708755-32107119-20678685 12517-12519 32107119 denotes 30
32708755-32065055-20678686 13151-13153 32065055 denotes 32
32708755-32366817-20678687 13154-13156 32366817 denotes 33
32708755-32065055-20678688 13753-13755 32065055 denotes 32
32708755-32366817-20678689 13756-13758 32366817 denotes 33
32708755-32404477-20678690 13759-13761 32404477 denotes 34
32708755-32253318-20678691 13765-13767 32253318 denotes 36
32708755-32243945-20678692 13768-13770 32243945 denotes 37
32708755-27082314-20678693 14469-14471 27082314 denotes 38
32708755-29434591-20678694 14475-14477 29434591 denotes 40
32708755-30554115-20678695 14478-14480 30554115 denotes 41
32708755-31427727-20678696 14481-14483 31427727 denotes 42
32708755-20599443-20678697 14487-14489 20599443 denotes 44
32708755-23249272-20678698 14490-14492 23249272 denotes 45
32708755-19404405-20678699 15788-15790 19404405 denotes 47
32708755-19700132-20678700 16117-16119 19700132 denotes 22
32708755-23630610-20678701 16120-16122 23630610 denotes 49
32708755-12967627-20678702 16381-16383 12967627 denotes 50
32708755-19221212-20678703 16530-16532 19221212 denotes 51
32708755-20797602-20678704 16924-16926 20797602 denotes 52
32708755-31427727-20678705 17382-17384 31427727 denotes 42
32708755-23884911-20678706 17437-17439 23884911 denotes 53
32708755-20975035-20678707 17619-17621 20975035 denotes 54
32708755-16166274-20678708 18266-18268 16166274 denotes 55
32708755-16166274-20678709 18366-18368 16166274 denotes 55
32708755-24147777-20678710 18458-18460 24147777 denotes 56
32708755-30989646-20678711 18662-18664 30989646 denotes 57
32708755-25194138-20678712 19667-19669 25194138 denotes 60
32708755-2118838-20678713 20082-20084 2118838 denotes 62
32708755-9546381-20678714 20327-20329 9546381 denotes 63
32708755-21874245-20678715 20471-20473 21874245 denotes 64
32708755-27660028-20678716 21173-21175 27660028 denotes 65
32708755-24505094-20678717 21427-21429 24505094 denotes 66
32708755-24168260-20678718 21581-21583 24168260 denotes 67
32708755-24168260-20678719 21855-21857 24168260 denotes 67
32708755-16007097-20678720 22716-22718 16007097 denotes 14
32708755-16001071-20678721 22719-22721 16001071 denotes 15
32708755-29434591-20678722 23255-23257 29434591 denotes 40
32708755-22339213-20678723 23527-23529 22339213 denotes 68
32708755-23889691-20678724 23669-23671 23889691 denotes 69
32708755-23488800-20678725 23759-23761 23488800 denotes 70
32708755-23547236-20678726 23880-23882 23547236 denotes 71
32708755-29616018-20678727 24074-24076 29616018 denotes 72
32708755-29616018-20678728 24233-24235 29616018 denotes 72
32708755-10749743-20678729 24435-24437 10749743 denotes 73
32708755-32161940-20678730 24579-24580 32161940 denotes 2
32708755-31986264-20678731 24581-24582 31986264 denotes 8
32708755-32297671-20678732 24583-24584 32297671 denotes 9
32708755-17303661-20678733 25153-25155 17303661 denotes 74
32708755-15897343-20678734 25514-25516 15897343 denotes 75
32708755-18849338-20678735 25765-25767 18849338 denotes 76
32708755-18849338-20678736 26117-26119 18849338 denotes 76
32708755-18768926-20678737 26120-26122 18768926 denotes 77
32708755-32075877-20678738 27878-27880 32075877 denotes 27
32708755-32065055-20678739 27881-27883 32065055 denotes 32
32708755-15791205-20678740 27983-27985 15791205 denotes 24
32708755-19901337-20678741 28140-28142 19901337 denotes 78
32708755-18490652-20678742 28372-28374 18490652 denotes 17
32708755-32142651-20678743 28668-28670 32142651 denotes 13
32708755-32161940-20678744 28747-28748 32161940 denotes 2
32708755-24147777-20678745 29097-29099 24147777 denotes 56
32708755-18490652-20678746 29387-29389 18490652 denotes 17
32708755-18490652-20678747 29649-29651 18490652 denotes 17
32708755-32142651-20678748 34311-34313 32142651 denotes 13
32708755-19995578-20678749 34429-34431 19995578 denotes 20
32708755-23488800-20678750 36089-36091 23488800 denotes 70
32708755-28018220-20678751 36432-36434 28018220 denotes 81
32708755-19948988-20678752 36811-36813 19948988 denotes 82
32708755-20713916-20678753 37005-37007 20713916 denotes 83
32708755-20713916-20678754 37278-37280 20713916 denotes 83
32708755-30913349-20678755 37435-37437 30913349 denotes 84
32708755-27730696-20678756 37652-37654 27730696 denotes 85
32708755-10969042-20678757 38444-38446 10969042 denotes 86
32708755-10924499-20678758 38447-38449 10924499 denotes 87
32708755-10969042-20678759 38565-38567 10969042 denotes 86
32708755-10924499-20678760 38568-38570 10924499 denotes 87
32708755-20599443-20678761 38754-38756 20599443 denotes 44
32708755-20599443-20678762 38856-38858 20599443 denotes 44
32708755-23249272-20678763 38859-38861 23249272 denotes 45
32708755-18849338-20678764 38865-38867 18849338 denotes 76
32708755-18768926-20678765 38868-38870 18768926 denotes 77
32708755-10924499-20678766 38871-38873 10924499 denotes 87
32708755-16007097-20678767 39054-39056 16007097 denotes 14
32708755-20599443-20678768 39060-39062 20599443 denotes 44
32708755-23249272-20678769 39063-39065 23249272 denotes 45
32708755-18849338-20678770 39069-39071 18849338 denotes 76
32708755-18768926-20678771 39072-39074 18768926 denotes 77
32708755-10924499-20678772 39075-39077 10924499 denotes 87
32708755-18022664-20678773 39078-39080 18022664 denotes 88
32708755-16306622-20678774 39081-39083 16306622 denotes 89
32708755-16007097-20678775 39357-39359 16007097 denotes 14
32708755-20599443-20678776 39360-39362 20599443 denotes 44
32708755-23249272-20678777 39363-39365 23249272 denotes 45
32708755-10969042-20678778 39369-39371 10969042 denotes 86
32708755-10924499-20678779 39372-39374 10924499 denotes 87
32708755-18022664-20678780 39375-39377 18022664 denotes 88
32708755-16306622-20678781 39378-39380 16306622 denotes 89
32708755-20599443-20678782 40012-40014 20599443 denotes 44
32708755-32109013-20678783 40185-40186 32109013 denotes 5
32708755-30266430-20678784 40471-40473 30266430 denotes 91
32708755-32294485-20678785 40761-40762 32294485 denotes 6
32708755-31986264-20678786 40763-40764 31986264 denotes 8
32708755-24505094-20678787 40765-40767 24505094 denotes 66
32708755-30845246-20678788 40768-40770 30845246 denotes 92
32708755-30266430-20678789 41159-41161 30266430 denotes 91
32708755-21827444-20678790 41212-41214 21827444 denotes 93
32708755-28570269-20678791 41215-41217 28570269 denotes 94
32708755-21827444-20678792 41494-41496 21827444 denotes 93
32708755-31426452-20678793 41930-41932 31426452 denotes 95
32708755-31426452-20678794 42054-42056 31426452 denotes 95
32708755-31426452-20678795 42204-42206 31426452 denotes 95
32708755-32294485-20678796 42729-42730 32294485 denotes 6
32708755-31986264-20678797 42731-42732 31986264 denotes 8
32708755-25813276-20678798 43168-43170 25813276 denotes 96
32708755-28953660-20678799 44045-44048 28953660 denotes 100
32708755-20617034-20678800 44053-44056 20617034 denotes 102
32708755-32276440-20678801 44537-44540 32276440 denotes 103
32708755-30718726-20678802 44541-44544 30718726 denotes 104
32708755-32276440-20678803 44727-44730 32276440 denotes 103
32708755-32161940-20678804 44812-44813 32161940 denotes 2
32708755-31986264-20678805 44814-44815 31986264 denotes 8
32708755-32297671-20678806 44816-44817 32297671 denotes 9
32708755-32276440-20678807 45000-45003 32276440 denotes 103
32708755-20617034-20678808 45168-45171 20617034 denotes 102
32708755-32408070-20678809 45256-45259 32408070 denotes 107
32708755-20617034-20678810 45315-45318 20617034 denotes 102
32708755-30718726-20678811 45532-45535 30718726 denotes 104
32708755-29903860-20678812 45746-45749 29903860 denotes 108
32708755-20713898-20678813 45750-45753 20713898 denotes 109
32708755-18832706-20678814 45754-45757 18832706 denotes 110
32708755-32276440-20678815 45948-45951 32276440 denotes 103
32708755-30718726-20678816 45952-45955 30718726 denotes 104
32708755-28717982-20678817 46557-46560 28717982 denotes 111
32708755-28717982-20678818 46855-46858 28717982 denotes 111
32708755-28717982-20678819 47060-47063 28717982 denotes 111
32708755-28717982-20678820 47572-47575 28717982 denotes 111
32708755-32132184-20678821 47847-47849 32132184 denotes 28
32708755-30266430-20678822 47991-47993 30266430 denotes 91
32708755-30266430-20678823 48933-48935 30266430 denotes 91
32708755-30266430-20678824 49109-49111 30266430 denotes 91
32708755-20617034-20678825 49112-49115 20617034 denotes 102
32708755-30266430-20678826 49878-49880 30266430 denotes 91
32708755-30266430-20678827 50105-50107 30266430 denotes 91
32708755-32161940-20678828 50461-50462 32161940 denotes 2
32708755-32171076-20678829 50463-50464 32171076 denotes 3
32708755-32294485-20678830 50465-50466 32294485 denotes 6
32708755-20617034-20678831 50735-50738 20617034 denotes 102
32708755-30266430-20678832 51101-51103 30266430 denotes 91
32708755-30266430-20678833 51214-51216 30266430 denotes 91
32708755-30266430-20678834 51780-51782 30266430 denotes 91
32708755-30266430-20678835 51894-51896 30266430 denotes 91
32708755-30266430-20678836 52016-52018 30266430 denotes 91
32708755-28953660-20678837 52569-52572 28953660 denotes 100
32708755-20617034-20678838 52577-52580 20617034 denotes 102
32708755-28953660-20678839 52691-52694 28953660 denotes 100
32708755-28953660-20678840 52878-52881 28953660 denotes 100
32708755-28953660-20678841 53062-53065 28953660 denotes 100
32708755-28953660-20678842 53162-53165 28953660 denotes 100
32708755-32132184-20678843 54090-54092 32132184 denotes 28
32708755-15791205-20678844 54657-54659 15791205 denotes 24
32708755-32132184-20678845 54841-54843 32132184 denotes 28
32708755-32132184-20678846 54908-54910 32132184 denotes 28
32708755-18490652-20678847 55340-55342 18490652 denotes 17
32708755-15791205-20678848 55343-55345 15791205 denotes 24
32708755-15791205-20678849 55611-55613 15791205 denotes 24
32708755-15791205-20678850 55814-55816 15791205 denotes 24
32708755-12358520-20678851 56030-56033 12358520 denotes 113
32708755-26851370-20678852 56034-56037 26851370 denotes 114
32708755-26851370-20678853 56124-56127 26851370 denotes 114
32708755-26851370-20678854 56310-56313 26851370 denotes 114
32708755-26851370-20678855 56661-56664 26851370 denotes 114
32708755-26851370-20678856 57028-57031 26851370 denotes 114
32708755-26851370-20678857 57128-57131 26851370 denotes 114
32708755-22777933-20678858 57359-57362 22777933 denotes 115
32708755-22777933-20678859 57844-57847 22777933 denotes 115
32708755-18223027-20678860 58343-58346 18223027 denotes 116
32708755-32132184-20678861 58472-58474 32132184 denotes 28
32708755-18235039-20678862 59030-59033 18235039 denotes 117
32708755-20300067-20678863 59153-59156 20300067 denotes 118
32708755-20599443-20678864 59533-59535 20599443 denotes 44
32708755-17579661-20678865 59768-59771 17579661 denotes 119
32708755-26851370-20678866 60317-60320 26851370 denotes 114
32708755-22777933-20678867 60321-60324 22777933 denotes 115
32708755-20797602-20678868 61051-61053 20797602 denotes 52
32708755-19517214-20678869 61547-61550 19517214 denotes 122
32708755-20717537-20678870 62131-62134 20717537 denotes 123
32708755-20717537-20678871 62733-62736 20717537 denotes 123
32708755-20617034-20678872 63063-63066 20617034 denotes 102
32708755-32132184-20678873 64306-64308 32132184 denotes 28
32708755-25271834-20678874 64630-64633 25271834 denotes 124
32708755-30266430-20678875 64844-64846 30266430 denotes 91
32708755-30316994-20678876 64951-64954 30316994 denotes 125
32708755-31171812-20678877 65154-65157 31171812 denotes 126
32708755-20717537-20678878 65985-65988 20717537 denotes 123
32708755-20717537-20678879 66153-66156 20717537 denotes 123
32708755-20717537-20678880 66244-66247 20717537 denotes 123
32708755-18223027-20678881 66698-66701 18223027 denotes 116
32708755-18223027-20678882 66953-66956 18223027 denotes 116
32708755-15492138-20678883 67750-67753 15492138 denotes 127
32708755-15492138-20678884 67927-67930 15492138 denotes 127
32708755-23769988-20678885 68390-68393 23769988 denotes 128
32708755-27082314-20678886 68544-68546 27082314 denotes 38
32708755-30554115-20678887 68550-68552 30554115 denotes 41
32708755-28717982-20678888 69030-69033 28717982 denotes 111
32708755-26106051-20678889 69288-69291 26106051 denotes 130
32708755-29387012-20678890 69954-69957 29387012 denotes 131
32708755-15367630-20678891 70095-70097 15367630 denotes 19
32708755-16510163-20678892 70098-70100 16510163 denotes 21
32708755-29903860-20678893 70407-70410 29903860 denotes 108
32708755-32333836-20678894 70411-70414 32333836 denotes 133
32708755-28877748-20678895 70415-70418 28877748 denotes 134
32708755-29903860-20678896 70797-70800 29903860 denotes 108
32708755-28877748-20678897 70801-70804 28877748 denotes 134
32708755-32077115-20678898 71105-71106 32077115 denotes 1
32708755-32161940-20678899 71107-71108 32161940 denotes 2
32708755-32171076-20678900 71109-71110 32171076 denotes 3
32708755-32109013-20678901 71113-71114 32109013 denotes 5
32708755-32294485-20678902 71115-71116 32294485 denotes 6
32708755-32091533-20678903 71117-71118 32091533 denotes 7
32708755-31986264-20678904 71119-71120 31986264 denotes 8
32708755-32297671-20678905 71121-71122 32297671 denotes 9
32708755-29449338-20678906 71498-71500 29449338 denotes 11
32708755-25813276-20678907 71737-71739 25813276 denotes 96
32708755-25813276-20678908 71856-71858 25813276 denotes 96
32708755-25813276-20678909 72048-72050 25813276 denotes 96
32708755-32171062-20678910 72251-72254 32171062 denotes 135
32708755-32222168-20678911 72255-72258 32222168 denotes 136
32708755-32222169-20678912 72259-72262 32222169 denotes 137
32708755-32665962-20678913 72263-72266 32665962 denotes 138
32708755-25813276-20678914 72550-72552 25813276 denotes 96
32708755-15897343-20678915 72706-72708 15897343 denotes 75
32708755-15897343-20678916 72917-72919 15897343 denotes 75
32708755-32294485-20678917 74079-74080 32294485 denotes 6
32708755-32356628-20678918 74097-74100 32356628 denotes 143
32708755-32228222-20678919 74328-74331 32228222 denotes 145
32708755-32474043-20678920 74332-74335 32474043 denotes 146
32708755-32422341-20678921 74336-74339 32422341 denotes 147
32708755-32302265-20678922 74340-74343 32302265 denotes 148
32708755-32474043-20678923 74668-74671 32474043 denotes 146
32708755-25813276-20678924 75743-75745 25813276 denotes 96
32708755-31989052-20678925 76000-76003 31989052 denotes 149
32708755-21895524-20678926 76004-76007 21895524 denotes 150
32708755-19700132-20678927 76393-76395 19700132 denotes 22
32708755-23630610-20678928 76396-76398 23630610 denotes 49
32708755-29897923-20678929 76399-76402 29897923 denotes 151
32708755-27738071-20678930 76403-76406 27738071 denotes 152
32708755-27738071-20678931 76723-76726 27738071 denotes 152
32708755-32077115-20678932 77570-77571 32077115 denotes 1
32708755-32161940-20678933 77572-77573 32161940 denotes 2
32708755-32171076-20678934 77574-77575 32171076 denotes 3
32708755-32109013-20678935 77578-77579 32109013 denotes 5
32708755-32294485-20678936 77580-77581 32294485 denotes 6
32708755-32091533-20678937 77582-77583 32091533 denotes 7
32708755-31986264-20678938 77584-77585 31986264 denotes 8
32708755-32297671-20678939 77586-77587 32297671 denotes 9
32708755-22386035-20678940 77631-77633 22386035 denotes 12
32708755-25813276-20678941 77919-77921 25813276 denotes 96
32708755-30554115-20678942 78475-78477 30554115 denotes 41
32708755-24842388-20678943 78478-78481 24842388 denotes 154
32708755-32665962-20678944 78996-78999 32665962 denotes 138
32708755-30227878-20678945 79000-79003 30227878 denotes 155
32708755-30675038-20678946 79004-79007 30675038 denotes 156
32708755-30335025-20678947 79012-79015 30335025 denotes 158
32708755-16283142-20678948 79016-79019 16283142 denotes 159
32708755-27310975-20678949 79020-79023 27310975 denotes 160
32708755-30917908-20678950 79024-79027 30917908 denotes 161
32708755-32133153-20678951 79028-79031 32133153 denotes 162
32708755-32170560-20678952 79032-79035 32170560 denotes 163
32708755-32665962-20678953 79230-79233 32665962 denotes 138
32708755-30227878-20678954 79234-79237 30227878 denotes 155
32708755-30675038-20678955 79238-79241 30675038 denotes 156
32708755-30335025-20678956 79246-79249 30335025 denotes 158
32708755-16283142-20678957 79250-79253 16283142 denotes 159
32708755-27310975-20678958 79254-79257 27310975 denotes 160
32708755-30917908-20678959 79258-79261 30917908 denotes 161
32708755-32665962-20678960 79503-79506 32665962 denotes 138
32708755-32342265-20678961 79656-79659 32342265 denotes 164
32708755-31694839-20678962 80050-80053 31694839 denotes 167
32708755-31694839-20678963 80652-80655 31694839 denotes 167
32708755-32555424-20678964 81739-81742 32555424 denotes 170
32708755-32505227-20678965 81747-81750 32505227 denotes 172
32708755-32065055-20678966 82732-82734 32065055 denotes 32
32708755-32366817-20678967 82735-82737 32366817 denotes 33
32708755-32404477-20678968 82738-82740 32404477 denotes 34
32708755-32253318-20678969 82744-82746 32253318 denotes 36
32708755-32243945-20678970 82747-82749 32243945 denotes 37
32708755-32505227-20678971 82750-82753 32505227 denotes 172
32708755-21937658-20678972 83345-83348 21937658 denotes 176
32708755-18832706-20678973 83841-83844 18832706 denotes 110
32708755-32171076-20678974 84575-84576 32171076 denotes 3
32708755-18223027-20678975 86045-86048 18223027 denotes 116
32708755-25813276-20678976 86124-86126 25813276 denotes 96
32708755-22777933-20678977 87089-87092 22777933 denotes 115
32708755-22777933-20678978 87278-87281 22777933 denotes 115
32708755-22777933-20678979 87401-87404 22777933 denotes 115
32708755-32048163-20678980 87696-87699 32048163 denotes 177
32708755-20599443-20678981 88642-88644 20599443 denotes 44
32708755-16001071-20678982 88732-88734 16001071 denotes 15
32708755-28877748-20678983 88820-88823 28877748 denotes 134
32708755-23681967-20678984 88949-88952 23681967 denotes 178
32708755-28877748-20678985 89024-89027 28877748 denotes 134
32708755-29903860-20678986 89076-89079 29903860 denotes 108
32708755-30845246-20678987 89489-89491 30845246 denotes 92
32708755-25107336-20678988 89723-89726 25107336 denotes 179
32708755-25107336-20678989 90021-90024 25107336 denotes 179
32708755-25107336-20678990 90369-90372 25107336 denotes 179
32708755-25107336-20678991 90457-90460 25107336 denotes 179
32708755-25107336-20678992 90853-90856 25107336 denotes 179
32708755-2170511-20678993 91188-91191 2170511 denotes 180
32708755-2170511-20678994 91353-91356 2170511 denotes 180
32708755-30845246-20678995 91807-91809 30845246 denotes 92
32708755-28877748-20678996 92010-92013 28877748 denotes 134
32708755-30845246-20678997 92194-92196 30845246 denotes 92
32708755-28877748-20678998 92197-92200 28877748 denotes 134
32708755-28877748-20678999 92353-92356 28877748 denotes 134
32708755-28877748-20679000 92404-92407 28877748 denotes 134
32708755-30845246-20679001 92781-92783 30845246 denotes 92
32708755-25107336-20679002 93197-93200 25107336 denotes 179
32708755-2170511-20679003 93201-93204 2170511 denotes 180
32708755-22777933-20679004 93283-93286 22777933 denotes 115
32708755-22518284-20679005 93287-93290 22518284 denotes 181
32708755-30845246-20679006 93383-93385 30845246 denotes 92
32708755-23681967-20679007 93851-93854 23681967 denotes 178
32708755-25107336-20679008 93855-93858 25107336 denotes 179
32708755-30845246-20679009 93961-93963 30845246 denotes 92
32708755-22777933-20679010 94376-94379 22777933 denotes 115
32708755-25107336-20679011 94380-94383 25107336 denotes 179
32708755-22518284-20679012 94384-94387 22518284 denotes 181
32708755-23681967-20679013 94705-94708 23681967 denotes 178
32708755-28877748-20679014 94729-94732 28877748 denotes 134
32708755-30845246-20679015 95047-95049 30845246 denotes 92
32708755-29903860-20679016 95334-95337 29903860 denotes 108
32708755-27432541-20679017 95338-95341 27432541 denotes 182
32708755-27432541-20679018 95439-95442 27432541 denotes 182
32708755-29903860-20679019 95655-95658 29903860 denotes 108
32708755-27432541-20679020 95659-95662 27432541 denotes 182
32708755-12358520-20679021 98269-98272 12358520 denotes 113
32708755-22777933-20679022 98395-98398 22777933 denotes 115
32708755-15791205-20679023 98605-98607 15791205 denotes 24
32708755-20797602-20679024 99008-99010 20797602 denotes 52
32708755-18235039-20679025 99011-99014 18235039 denotes 117
32708755-20300067-20679026 99015-99018 20300067 denotes 118
32708755-19517214-20679027 99019-99022 19517214 denotes 122
32708755-23370913-20679028 99023-99026 23370913 denotes 183
32708755-31982938-20679029 99027-99030 31982938 denotes 184
32708755-20797602-20679030 99565-99567 20797602 denotes 52
32708755-23370913-20679031 99568-99571 23370913 denotes 183
32708755-31982938-20679032 99572-99575 31982938 denotes 184
32708755-19517214-20679033 99904-99907 19517214 denotes 122
32708755-19517214-20679034 99989-99992 19517214 denotes 122
32708755-31645418-20679035 101106-101109 31645418 denotes 185
32708755-18223027-20679036 103076-103079 18223027 denotes 116
32708755-27432541-20679037 105802-105805 27432541 denotes 182
32708755-20717537-20679038 106143-106146 20717537 denotes 123
32708755-20717537-20679039 106191-106194 20717537 denotes 123
32708755-20717537-20679040 106818-106821 20717537 denotes 123
32708755-14007184-20679041 107198-107201 14007184 denotes 188
32708755-14007184-20679042 107471-107474 14007184 denotes 188
32708755-14007184-20679043 107616-107619 14007184 denotes 188
32708755-20717537-20679044 108252-108255 20717537 denotes 123
32708755-11149993-20679045 108357-108360 11149993 denotes 191
32708755-20717537-20679046 108833-108836 20717537 denotes 123