PMC:7405836 / 113185-117879 JSONTXT

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LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T31 21-29 Body_part denotes Antibody http://purl.org/sig/ont/fma/fma62871
T32 285-292 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T33 466-473 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T34 801-808 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T35 1067-1077 Body_part denotes amino acid http://purl.org/sig/ont/fma/fma82739
T36 1142-1152 Body_part denotes amino acid http://purl.org/sig/ont/fma/fma82739
T37 2094-2101 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T38 2809-2814 Body_part denotes serum http://purl.org/sig/ont/fma/fma63083
T39 2918-2924 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T40 3262-3276 Body_part denotes cell membranes http://purl.org/sig/ont/fma/fma63841
T41 3262-3266 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T42 3370-3378 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T43 3546-3554 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T44 3612-3620 Body_part denotes cysteine http://purl.org/sig/ont/fma/fma82751
T45 4003-4009 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T46 4103-4109 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T47 4150-4155 Body_part denotes serum http://purl.org/sig/ont/fma/fma63083
T48 4157-4165 Body_part denotes antibody http://purl.org/sig/ont/fma/fma62871
T49 4209-4217 Body_part denotes antibody http://purl.org/sig/ont/fma/fma62871
T50 4304-4310 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T51 4538-4544 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T129 2809-2814 Body_part denotes serum http://purl.obolibrary.org/obo/UBERON_0001977
T130 4150-4155 Body_part denotes serum http://purl.obolibrary.org/obo/UBERON_0001977

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T994 170-174 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T995 230-239 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T996 846-854 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T997 846-850 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T998 956-964 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T999 956-960 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T1000 1095-1103 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T1001 1095-1099 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T1002 1254-1262 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T1003 1254-1258 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T1004 1276-1284 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T1005 1276-1280 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T1006 1309-1317 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T1007 1309-1313 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T1008 1386-1394 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T1009 1542-1550 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T1010 1594-1602 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T1011 1594-1598 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T1012 1606-1614 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T1013 1686-1694 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T1014 1707-1715 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T1015 1707-1711 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T1016 1764-1772 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T1017 1764-1768 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T1018 1849-1857 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T1019 1979-1987 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T1020 2008-2016 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T1021 2008-2012 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T1022 2105-2113 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T1023 2105-2109 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T1024 2199-2207 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T1025 2199-2203 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T1026 2212-2220 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T1027 2212-2216 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T1028 2422-2430 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T1029 2975-2983 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T1030 3421-3430 Disease denotes influenza http://purl.obolibrary.org/obo/MONDO_0005812
T1031 3438-3449 Disease denotes hepatitis C http://purl.obolibrary.org/obo/MONDO_0005231
T1032 3438-3447 Disease denotes hepatitis http://purl.obolibrary.org/obo/MONDO_0002251
T1033 3457-3462 Disease denotes Ebola http://purl.obolibrary.org/obo/MONDO_0005737
T1034 3474-3480 Disease denotes dengue http://purl.obolibrary.org/obo/MONDO_0005502
T1035 3963-3972 Disease denotes pneumonia http://purl.obolibrary.org/obo/MONDO_0005249
T1036 3980-3988 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T1037 4123-4131 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T1038 4123-4127 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T1039 4427-4431 Disease denotes ARDS http://purl.obolibrary.org/obo/MONDO_0006502

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T101 247-248 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T102 385-393 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T103 610-611 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T104 664-665 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T105 1028-1031 http://purl.obolibrary.org/obo/NCBITaxon_9397 denotes bat
T106 1113-1116 http://purl.obolibrary.org/obo/NCBITaxon_9397 denotes bat
T107 1224-1225 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T108 1725-1730 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T109 1808-1809 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T110 2133-2134 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T111 2558-2563 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T112 2710-2713 http://purl.obolibrary.org/obo/CLO_0001180 denotes 203
T113 2716-2717 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T114 2728-2734 http://purl.obolibrary.org/obo/NCBITaxon_33208 denotes animal
T115 2832-2838 http://purl.obolibrary.org/obo/NCBITaxon_9837 denotes camels
T116 2918-2924 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T117 3050-3055 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T118 3068-3073 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T119 3111-3120 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes humanized
T120 3195-3200 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T121 3247-3252 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T122 3262-3266 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T123 3267-3276 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membranes
T124 3364-3369 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T125 3431-3436 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T126 3450-3455 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T127 3463-3468 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T128 3481-3486 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T129 3721-3726 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T130 3744-3745 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T131 3773-3774 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T132 3826-3831 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T133 3895-3896 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T134 4003-4009 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T135 4103-4109 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T136 4121-4122 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T137 4304-4310 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T138 4332-4333 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T139 4538-4544 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T140 4689-4692 http://purl.obolibrary.org/obo/CLO_0001006 denotes 311

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T11445 285-292 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T215 335-342 Chemical denotes epitope http://purl.obolibrary.org/obo/CHEBI_53000
T216 406-417 Chemical denotes sialic acid http://purl.obolibrary.org/obo/CHEBI_26667
T217 413-417 Chemical denotes acid http://purl.obolibrary.org/obo/CHEBI_37527
T218 466-473 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T219 801-808 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T220 1013-1015 Chemical denotes SL http://purl.obolibrary.org/obo/CHEBI_74815
T221 1032-1034 Chemical denotes SL http://purl.obolibrary.org/obo/CHEBI_74815
T222 1067-1077 Chemical denotes amino acid http://purl.obolibrary.org/obo/CHEBI_33709
T223 1067-1072 Chemical denotes amino http://purl.obolibrary.org/obo/CHEBI_46882
T224 1073-1077 Chemical denotes acid http://purl.obolibrary.org/obo/CHEBI_37527
T225 1117-1119 Chemical denotes SL http://purl.obolibrary.org/obo/CHEBI_74815
T226 1142-1152 Chemical denotes amino acid http://purl.obolibrary.org/obo/CHEBI_33709
T227 1142-1147 Chemical denotes amino http://purl.obolibrary.org/obo/CHEBI_46882
T228 1148-1152 Chemical denotes acid http://purl.obolibrary.org/obo/CHEBI_37527
T229 1669-1673 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T230 1674-1684 Chemical denotes remdesivir http://purl.obolibrary.org/obo/CHEBI_145994
T231 2094-2101 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T232 2535-2545 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T233 2655-2665 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T234 3165-3167 Chemical denotes VH http://purl.obolibrary.org/obo/CHEBI_73700
T235 3370-3378 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T236 3546-3554 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T237 3612-3620 Chemical denotes cysteine http://purl.obolibrary.org/obo/CHEBI_15356
T238 4448-4461 Chemical denotes antimicrobial http://purl.obolibrary.org/obo/CHEBI_33281

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T21 385-400 http://purl.obolibrary.org/obo/GO_0061025 denotes membrane fusion
T22 3700-3713 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T23 4545-4553 http://purl.obolibrary.org/obo/GO_0015297 denotes exchange

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T770 0-41 Sentence denotes Passive Immunization/Antibody Therapy/MAb
T771 42-144 Sentence denotes Monoclonal antibodies (MAbs) may be helpful in the intervention of disease in CoV-exposed individuals.
T772 145-246 Sentence denotes Patients recovering from SARS showed robust neutralizing antibodies against this CoV infection (164).
T773 247-485 Sentence denotes A set of MAbs aimed at the MERS-CoV S protein-specific domains, comprising six specific epitope groups interacting with receptor-binding, membrane fusion, and sialic acid-binding sites, make up crucial entry tasks of S protein (198, 199).
T774 486-638 Sentence denotes Passive immunization employing weaker and strongly neutralizing antibodies provided considerable protection in mice against a MERS-CoV lethal challenge.
T775 639-809 Sentence denotes Such antibodies may play a crucial role in enhancing protective humoral responses against the emerging CoVs by aiming appropriate epitopes and functions of the S protein.
T776 810-1172 Sentence denotes The cross-neutralization ability of SARS-CoV RBD-specific neutralizing MAbs considerably relies on the resemblance between their RBDs; therefore, SARS-CoV RBD-specific antibodies could cross-neutralized SL CoVs, i.e., bat-SL-CoV strain WIV1 (RBD with eight amino acid differences from SARS-CoV) but not bat-SL-CoV strain SHC014 (24 amino acid differences) (200).
T777 1173-1438 Sentence denotes Appropriate RBD-specific MAbs can be recognized by a relative analysis of RBD of SARS-CoV-2 to that of SARS-CoV, and cross-neutralizing SARS-CoV RBD-specific MAbs could be explored for their effectiveness against COVID-19 and further need to be assessed clinically.
T778 1439-1551 Sentence denotes The U.S. biotechnology company Regeneron is attempting to recognize potent and specific MAbs to combat COVID-19.
T779 1552-1702 Sentence denotes An ideal therapeutic option suggested for SARS-CoV-2 (COVID-19) is the combination therapy comprised of MAbs and the drug remdesivir (COVID-19) (201).
T780 1703-1858 Sentence denotes The SARS-CoV-specific human MAb CR3022 is found to bind with SARS-CoV-2 RBD, indicating its potential as a therapeutic agent in the management of COVID-19.
T781 1859-1994 Sentence denotes It can be used alone or in combination with other effective neutralizing antibodies for the treatment and prevention of COVID-19 (202).
T782 1995-2257 Sentence denotes Furthermore, SARS-CoV-specific neutralizing antibodies, like m396 and CR3014, failed to bind the S protein of SARS-CoV-2, indicating that a particular level of similarity is mandatory between the RBDs of SARS-CoV and SARS-CoV-2 for the cross-reactivity to occur.
T783 2258-2354 Sentence denotes Further assessment is necessary before confirming the effectiveness of such combination therapy.
T784 2355-2504 Sentence denotes In addition, to prevent further community and nosocomial spread of COVID-19, the postprocedure risk management program should not be neglected (309).
T785 2505-2715 Sentence denotes Development of broad-spectrum inhibitors against the human coronaviral pathogens will help to facilitate clinical trials on the effectiveness of such inhibitors against endemic and emerging coronaviruses (203).
T786 2716-2876 Sentence denotes A promising animal study revealed the protective effect of passive immunotherapy with immune serum from MERS-immune camels on mice infected with MERS-CoV (204).
T787 2877-3024 Sentence denotes Passive immunotherapy using convalescent plasma is another strategy that can be used for treating COVID-19-infected, critically ill patients (205).
T788 3025-3379 Sentence denotes The exploration of fully human antibodies (human single-chain antibodies; HuscFvs) or humanized nanobodies (single-domain antibodies; sdAb, VH/VHH) could aid in blocking virus replication, as these agents can traverse the virus-infected cell membranes (transbodies) and can interfere with the biological characteristics of the replicating virus proteins.
T789 3380-3493 Sentence denotes Such examples include transbodies to the influenza virus, hepatitis C virus, Ebola virus, and dengue virus (206).
T790 3494-3891 Sentence denotes Producing similar transbodies against intracellular proteins of coronaviruses, such as papain-like proteases (PLpro), cysteine-like protease (3CLpro), or other nsps, which are essential for replication and transcription of the virus, might formulate a practical move forward for a safer and potent passive immunization approach for virus-exposed persons and rendering therapy to infected patients.
T791 3892-4085 Sentence denotes In a case study on five grimly sick patients having symptoms of severe pneumonia due to COVID-19, convalescent plasma administration was found to be helpful in patients recovering successfully.
T792 4086-4389 Sentence denotes The convalescent plasma containing a SARS-CoV-2-specific ELISA (serum) antibody titer higher than 1:1,000 and neutralizing antibody titer more significant than 40 was collected from the recovered patients and used for plasma transfusion twice in a volume of 200 to 250 ml on the day of collection (310).
T793 4390-4507 Sentence denotes At present, treatment for sepsis and ARDS mainly involves antimicrobial therapy, source control, and supportive care.
T794 4508-4617 Sentence denotes Hence, the use of therapeutic plasma exchange can be considered an option in managing such severe conditions.
T795 4618-4694 Sentence denotes Further randomized trials can be designed to investigate its efficacy (311).

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T80 3438-3447 Phenotype denotes hepatitis http://purl.obolibrary.org/obo/HP_0012115
T81 3963-3972 Phenotype denotes pneumonia http://purl.obolibrary.org/obo/HP_0002090
T82 4416-4422 Phenotype denotes sepsis http://purl.obolibrary.org/obo/HP_0100806

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
3082 1113-1116 Gene denotes bat Gene:570
3083 1028-1031 Gene denotes bat Gene:570
3084 385-393 Gene denotes membrane Gene:43740571
3085 120-123 Species denotes CoV Tax:11118
3086 145-153 Species denotes Patients Tax:9606
3087 226-229 Species denotes CoV Tax:11118
3088 274-282 Species denotes MERS-CoV Tax:1335626
3089 597-601 Species denotes mice Tax:10090
3090 612-620 Species denotes MERS-CoV Tax:1335626
3091 742-746 Species denotes CoVs Tax:11118
3092 846-854 Species denotes SARS-CoV Tax:694009
3093 956-964 Species denotes SARS-CoV Tax:694009
3094 1016-1020 Species denotes CoVs Tax:11118
3095 1035-1038 Species denotes CoV Tax:11118
3096 1095-1103 Species denotes SARS-CoV Tax:694009
3097 1120-1123 Species denotes CoV Tax:11118
3098 406-417 Chemical denotes sialic acid MESH:D019158
3099 230-239 Disease denotes infection MESH:D007239
3120 1254-1264 Species denotes SARS-CoV-2 Tax:2697049
3121 1276-1284 Species denotes SARS-CoV Tax:694009
3122 1309-1317 Species denotes SARS-CoV Tax:694009
3123 1594-1604 Species denotes SARS-CoV-2 Tax:2697049
3124 1707-1715 Species denotes SARS-CoV Tax:694009
3125 1725-1730 Species denotes human Tax:9606
3126 1764-1774 Species denotes SARS-CoV-2 Tax:2697049
3127 2008-2016 Species denotes SARS-CoV Tax:694009
3128 2105-2115 Species denotes SARS-CoV-2 Tax:2697049
3129 2199-2207 Species denotes SARS-CoV Tax:694009
3130 2212-2222 Species denotes SARS-CoV-2 Tax:2697049
3131 1674-1684 Chemical denotes remdesivir MESH:C000606551
3132 1735-1741 Chemical denotes CR3022
3133 2065-2071 Chemical denotes CR3014
3134 1386-1394 Disease denotes COVID-19 MESH:C000657245
3135 1542-1550 Disease denotes COVID-19 MESH:C000657245
3136 1606-1614 Disease denotes COVID-19 MESH:C000657245
3137 1686-1694 Disease denotes COVID-19 MESH:C000657245
3138 1849-1857 Disease denotes COVID-19 MESH:C000657245
3139 1979-1987 Disease denotes COVID-19 MESH:C000657245
3151 2558-2563 Species denotes human Tax:9606
3152 2564-2575 Species denotes coronaviral Tax:11118
3153 2695-2708 Species denotes coronaviruses Tax:11118
3154 2832-2838 Species denotes camels Tax:9838
3155 2842-2846 Species denotes mice Tax:10090
3156 2861-2869 Species denotes MERS-CoV Tax:1335626
3157 3009-3017 Species denotes patients Tax:9606
3158 2422-2430 Disease denotes COVID-19 MESH:C000657245
3159 2847-2855 Disease denotes infected MESH:D007239
3160 2975-2992 Disease denotes COVID-19-infected MESH:C000657245
3161 2994-3008 Disease denotes critically ill MESH:D016638
3174 3179-3182 Gene denotes aid Gene:57379
3175 3421-3436 Species denotes influenza virus Tax:11308
3176 3438-3455 Species denotes hepatitis C virus Tax:11103
3177 3457-3468 Species denotes Ebola virus Tax:1570291
3178 3474-3486 Species denotes dengue virus Tax:12637
3179 3558-3571 Species denotes coronaviruses Tax:11118
3180 3840-3847 Species denotes persons Tax:9606
3181 3882-3890 Species denotes patients Tax:9606
3182 3050-3055 Species denotes human Tax:9606
3183 3068-3073 Species denotes human Tax:9606
3184 3247-3261 Disease denotes virus-infected MESH:D001102
3185 3873-3881 Disease denotes infected MESH:D007239
3194 3928-3936 Species denotes patients Tax:9606
3195 4052-4060 Species denotes patients Tax:9606
3196 4123-4133 Species denotes SARS-CoV-2 Tax:2697049
3197 4282-4290 Species denotes patients Tax:9606
3198 3963-3972 Disease denotes pneumonia MESH:D011014
3199 3980-3988 Disease denotes COVID-19 MESH:C000657245
3200 4416-4422 Disease denotes sepsis MESH:D018805
3201 4427-4431 Disease denotes ARDS MESH:D012128