PMC:7405836 / 111143-111477 JSONTXT

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T27","span":{"begin":263,"end":269},"obj":"Body_part"}],"attributes":[{"id":"A27","pred":"fma_id","subj":"T27","obj":"http://purl.org/sig/ont/fma/fma62970"}],"text":"Based on the pharmacokinetic simulation, it was also found that ivermectin may have limited therapeutic utility in managing COVID-19, since the inhibitory concentration that has to be achieved for effective anti-SARS-CoV-2 activity is far higher than the maximum plasma concentration achieved by administering the approved dose (340)."}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T984","span":{"begin":124,"end":132},"obj":"Disease"},{"id":"T985","span":{"begin":212,"end":220},"obj":"Disease"},{"id":"T986","span":{"begin":212,"end":216},"obj":"Disease"}],"attributes":[{"id":"A984","pred":"mondo_id","subj":"T984","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A985","pred":"mondo_id","subj":"T985","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A986","pred":"mondo_id","subj":"T986","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"}],"text":"Based on the pharmacokinetic simulation, it was also found that ivermectin may have limited therapeutic utility in managing COVID-19, since the inhibitory concentration that has to be achieved for effective anti-SARS-CoV-2 activity is far higher than the maximum plasma concentration achieved by administering the approved dose (340)."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T78","span":{"begin":174,"end":177},"obj":"http://purl.obolibrary.org/obo/CLO_0051582"},{"id":"T79","span":{"begin":223,"end":231},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T80","span":{"begin":263,"end":269},"obj":"http://purl.obolibrary.org/obo/UBERON_0001969"}],"text":"Based on the pharmacokinetic simulation, it was also found that ivermectin may have limited therapeutic utility in managing COVID-19, since the inhibitory concentration that has to be achieved for effective anti-SARS-CoV-2 activity is far higher than the maximum plasma concentration achieved by administering the approved dose (340)."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T185","span":{"begin":64,"end":74},"obj":"Chemical"}],"attributes":[{"id":"A185","pred":"chebi_id","subj":"T185","obj":"http://purl.obolibrary.org/obo/CHEBI_6078"}],"text":"Based on the pharmacokinetic simulation, it was also found that ivermectin may have limited therapeutic utility in managing COVID-19, since the inhibitory concentration that has to be achieved for effective anti-SARS-CoV-2 activity is far higher than the maximum plasma concentration achieved by administering the approved dose (340)."}

{"project":"LitCovid-sentences","denotations":[{"id":"T758","span":{"begin":0,"end":334},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Based on the pharmacokinetic simulation, it was also found that ivermectin may have limited therapeutic utility in managing COVID-19, since the inhibitory concentration that has to be achieved for effective anti-SARS-CoV-2 activity is far higher than the maximum plasma concentration achieved by administering the approved dose (340)."}

{"project":"LitCovid-PubTator","denotations":[{"id":"3036","span":{"begin":212,"end":222},"obj":"Species"},{"id":"3043","span":{"begin":124,"end":132},"obj":"Disease"}],"attributes":[{"id":"A3036","pred":"tao:has_database_id","subj":"3036","obj":"Tax:2697049"},{"id":"A3043","pred":"tao:has_database_id","subj":"3043","obj":"MESH:C000657245"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"Based on the pharmacokinetic simulation, it was also found that ivermectin may have limited therapeutic utility in managing COVID-19, since the inhibitory concentration that has to be achieved for effective anti-SARS-CoV-2 activity is far higher than the maximum plasma concentration achieved by administering the approved dose (340)."}