PMC:7405836 / 109038-110552
Annnotations
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T22 | 106-110 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
| T23 | 133-142 | Body_part | denotes | endosomal | http://purl.org/sig/ont/fma/fma67180 |
| T24 | 869-872 | Body_part | denotes | arm | http://purl.org/sig/ont/fma/fma24890 |
LitCovid-PD-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T126 | 869-872 | Body_part | denotes | arm | http://purl.obolibrary.org/obo/UBERON_0001460 |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T975 | 265-273 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T976 | 265-269 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T977 | 483-491 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T978 | 483-487 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T979 | 505-514 | Disease | denotes | pneumonia | http://purl.obolibrary.org/obo/MONDO_0005249 |
| T980 | 771-779 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T981 | 1257-1265 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T65 | 63-71 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activity |
| T66 | 100-105 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T67 | 106-110 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
| T68 | 192-197 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T69 | 317-318 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T70 | 860-861 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T71 | 869-872 | http://www.ebi.ac.uk/efo/EFO_0001410 | denotes | arm |
| T72 | 929-930 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T73 | 991-992 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T74 | 1043-1044 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T163 | 0-11 | Chemical | denotes | Chloroquine | http://purl.obolibrary.org/obo/CHEBI_3638 |
| T164 | 18-30 | Chemical | denotes | antimalarial | http://purl.obolibrary.org/obo/CHEBI_38068 |
| T165 | 31-35 | Chemical | denotes | drug | http://purl.obolibrary.org/obo/CHEBI_23888 |
| T166 | 53-62 | Chemical | denotes | antiviral | http://purl.obolibrary.org/obo/CHEBI_22587 |
| T167 | 382-393 | Chemical | denotes | chloroquine | http://purl.obolibrary.org/obo/CHEBI_3638 |
| T168 | 394-403 | Chemical | denotes | phosphate | http://purl.obolibrary.org/obo/CHEBI_18367|http://purl.obolibrary.org/obo/CHEBI_26020|http://purl.obolibrary.org/obo/CHEBI_35780|http://purl.obolibrary.org/obo/CHEBI_43474 |
| T172 | 527-531 | Chemical | denotes | drug | http://purl.obolibrary.org/obo/CHEBI_23888 |
| T173 | 694-712 | Chemical | denotes | hydroxychloroquine | http://purl.obolibrary.org/obo/CHEBI_5801 |
| T174 | 722-736 | Chemical | denotes | aminoquinoline | http://purl.obolibrary.org/obo/CHEBI_36709 |
| T175 | 737-741 | Chemical | denotes | drug | http://purl.obolibrary.org/obo/CHEBI_23888 |
| T176 | 808-826 | Chemical | denotes | hydroxychloroquine | http://purl.obolibrary.org/obo/CHEBI_5801 |
| T177 | 844-856 | Chemical | denotes | azithromycin | http://purl.obolibrary.org/obo/CHEBI_2955 |
| T178 | 1205-1223 | Chemical | denotes | hydroxychloroquine | http://purl.obolibrary.org/obo/CHEBI_5801 |
| T179 | 1224-1236 | Chemical | denotes | azithromycin | http://purl.obolibrary.org/obo/CHEBI_2955 |
LitCovid-PD-GO-BP
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T9 | 106-117 | http://purl.obolibrary.org/obo/GO_0140253 | denotes | cell fusion |
| T10 | 106-117 | http://purl.obolibrary.org/obo/GO_0045026 | denotes | cell fusion |
| T11 | 106-117 | http://purl.obolibrary.org/obo/GO_0000768 | denotes | cell fusion |
| T12 | 106-117 | http://purl.obolibrary.org/obo/GO_0000747 | denotes | cell fusion |
| T13 | 239-261 | http://purl.obolibrary.org/obo/GO_0033578 | denotes | terminal glycosylation |
| T14 | 248-261 | http://purl.obolibrary.org/obo/GO_0070085 | denotes | glycosylation |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T743 | 0-167 | Sentence | denotes | Chloroquine is an antimalarial drug known to possess antiviral activity due to its ability to block virus-cell fusion by raising the endosomal pH necessary for fusion. |
| T744 | 168-313 | Sentence | denotes | It also interferes with virus-receptor binding by interfering with the terminal glycosylation of SARS-CoV cellular receptors, such as ACE2 (196). |
| T745 | 314-521 | Sentence | denotes | In a recent multicenter clinical trial that was conducted in China, chloroquine phosphate was found to exhibit both efficacy and safety in the therapeutic management of SARS-CoV-2-associated pneumonia (197). |
| T746 | 522-655 | Sentence | denotes | This drug is already included in the treatment guidelines issued by the National Health Commission of the People’s Republic of China. |
| T747 | 656-766 | Sentence | denotes | The preliminary clinical trials using hydroxychloroquine, another aminoquinoline drug, gave promising results. |
| T748 | 767-882 | Sentence | denotes | The COVID-19 patients received 600 mg of hydroxychloroquine daily along with azithromycin as a single-arm protocol. |
| T749 | 883-966 | Sentence | denotes | This protocol was found to be associated with a noteworthy reduction in viral load. |
| T750 | 967-1123 | Sentence | denotes | Finally, it resulted in a complete cure (271); however, the study comprised a small population and, hence, the possibility of misinterpretation could arise. |
| T751 | 1124-1332 | Sentence | denotes | However, in another case study, the authors raised concerns over the efficacy of hydroxychloroquine-azithromycin in the treatment of COVID-19 patients, since no observable effect was seen when they were used. |
| T752 | 1333-1428 | Sentence | denotes | In some cases, the treatment was discontinued due to the prolongation of the QT interval (307). |
| T753 | 1429-1514 | Sentence | denotes | Hence, further randomized clinical trials are required before concluding this matter. |
LitCovid-PD-HP
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T79 | 505-514 | Phenotype | denotes | pneumonia | http://purl.obolibrary.org/obo/HP_0002090 |
LitCovid-PubTator
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
|---|---|---|---|---|---|
| 3002 | 302-306 | Gene | denotes | ACE2 | Gene:59272 |
| 3003 | 265-273 | Species | denotes | SARS-CoV | Tax:694009 |
| 3004 | 483-493 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
| 3005 | 628-634 | Species | denotes | People | Tax:9606 |
| 3006 | 780-788 | Species | denotes | patients | Tax:9606 |
| 3007 | 1266-1274 | Species | denotes | patients | Tax:9606 |
| 3008 | 375-380 | Species | denotes | China | Tax:998089 |
| 3009 | 649-654 | Species | denotes | China | Tax:998089 |
| 3010 | 0-11 | Chemical | denotes | Chloroquine | MESH:D002738 |
| 3011 | 382-403 | Chemical | denotes | chloroquine phosphate | MESH:C023676 |
| 3012 | 694-712 | Chemical | denotes | hydroxychloroquine | MESH:D006886 |
| 3013 | 722-736 | Chemical | denotes | aminoquinoline | MESH:D000634 |
| 3014 | 808-826 | Chemical | denotes | hydroxychloroquine | MESH:D006886 |
| 3015 | 844-856 | Chemical | denotes | azithromycin | MESH:D017963 |
| 3016 | 1205-1236 | Chemical | denotes | hydroxychloroquine-azithromycin | |
| 3017 | 505-514 | Disease | denotes | pneumonia | MESH:D011014 |
| 3018 | 771-779 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 3019 | 1257-1265 | Disease | denotes | COVID-19 | MESH:C000657245 |