PMC:7402624 / 68377-69536 JSONTXT

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T534","span":{"begin":60,"end":64},"obj":"Body_part"}],"attributes":[{"id":"A534","pred":"fma_id","subj":"T534","obj":"http://purl.org/sig/ont/fma/fma68646"}],"text":"To identify subjects where the frequency of specific immune cell populations increased, decreased or stayed stable over time (day 0 to day 7), where data was available we used a previously published dataset to establish a standard range of fold change over time in a healthy cohort (44). A fold change greater than the mean fold change ± 2 standard deviations was considered an increase, less than this range was considered a decrease, and within this range was considered stable. Where this data was not available, a fold change from day 0 to day 7 of between 0.5 and 1.5 was considered stable. A fold change \u003c0.5 was considered decreased, and \u003e1.5 was considered increased. In order to eliminate redundant tests and maximize statistical power, the pairwise statistical tests shown in Fig. 5G were performed using fold-change as a continuous metric, irrespective of the discrete up/stable/down classification described above. Similarly, in fig. S9G, pairwise association tests between changes in UMAP Component coordinates and clinical data were performed using each difference value as a continuous metric, irrespective of the up/stable/down classification."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T992","span":{"begin":60,"end":64},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T993","span":{"begin":176,"end":177},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T994","span":{"begin":220,"end":221},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T995","span":{"begin":265,"end":266},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T996","span":{"begin":288,"end":289},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T997","span":{"begin":424,"end":425},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T998","span":{"begin":516,"end":517},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T999","span":{"begin":596,"end":597},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T1000","span":{"begin":708,"end":713},"obj":"http://purl.obolibrary.org/obo/UBERON_0000473"},{"id":"T1001","span":{"begin":771,"end":776},"obj":"http://purl.obolibrary.org/obo/UBERON_0000473"},{"id":"T1002","span":{"begin":830,"end":831},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T1003","span":{"begin":972,"end":977},"obj":"http://purl.obolibrary.org/obo/UBERON_0000473"},{"id":"T1004","span":{"begin":1088,"end":1089},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"}],"text":"To identify subjects where the frequency of specific immune cell populations increased, decreased or stayed stable over time (day 0 to day 7), where data was available we used a previously published dataset to establish a standard range of fold change over time in a healthy cohort (44). A fold change greater than the mean fold change ± 2 standard deviations was considered an increase, less than this range was considered a decrease, and within this range was considered stable. Where this data was not available, a fold change from day 0 to day 7 of between 0.5 and 1.5 was considered stable. A fold change \u003c0.5 was considered decreased, and \u003e1.5 was considered increased. In order to eliminate redundant tests and maximize statistical power, the pairwise statistical tests shown in Fig. 5G were performed using fold-change as a continuous metric, irrespective of the discrete up/stable/down classification described above. Similarly, in fig. S9G, pairwise association tests between changes in UMAP Component coordinates and clinical data were performed using each difference value as a continuous metric, irrespective of the up/stable/down classification."}

{"project":"LitCovid-sentences","denotations":[{"id":"T421","span":{"begin":0,"end":287},"obj":"Sentence"},{"id":"T422","span":{"begin":288,"end":480},"obj":"Sentence"},{"id":"T423","span":{"begin":481,"end":595},"obj":"Sentence"},{"id":"T424","span":{"begin":596,"end":675},"obj":"Sentence"},{"id":"T425","span":{"begin":676,"end":926},"obj":"Sentence"},{"id":"T426","span":{"begin":927,"end":1159},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"To identify subjects where the frequency of specific immune cell populations increased, decreased or stayed stable over time (day 0 to day 7), where data was available we used a previously published dataset to establish a standard range of fold change over time in a healthy cohort (44). A fold change greater than the mean fold change ± 2 standard deviations was considered an increase, less than this range was considered a decrease, and within this range was considered stable. Where this data was not available, a fold change from day 0 to day 7 of between 0.5 and 1.5 was considered stable. A fold change \u003c0.5 was considered decreased, and \u003e1.5 was considered increased. In order to eliminate redundant tests and maximize statistical power, the pairwise statistical tests shown in Fig. 5G were performed using fold-change as a continuous metric, irrespective of the discrete up/stable/down classification described above. Similarly, in fig. S9G, pairwise association tests between changes in UMAP Component coordinates and clinical data were performed using each difference value as a continuous metric, irrespective of the up/stable/down classification."}