PMC:7402624 / 59616-60027 JSONTXT

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T500","span":{"begin":70,"end":74},"obj":"Body_part"},{"id":"T501","span":{"begin":147,"end":152},"obj":"Body_part"},{"id":"T502","span":{"begin":164,"end":166},"obj":"Body_part"},{"id":"T503","span":{"begin":288,"end":293},"obj":"Body_part"},{"id":"T504","span":{"begin":314,"end":318},"obj":"Body_part"},{"id":"T505","span":{"begin":348,"end":350},"obj":"Body_part"},{"id":"T506","span":{"begin":364,"end":369},"obj":"Body_part"}],"attributes":[{"id":"A500","pred":"fma_id","subj":"T500","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A501","pred":"fma_id","subj":"T501","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A502","pred":"fma_id","subj":"T502","obj":"http://purl.org/sig/ont/fma/fma84371"},{"id":"A503","pred":"fma_id","subj":"T503","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A504","pred":"fma_id","subj":"T504","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A505","pred":"fma_id","subj":"T505","obj":"http://purl.org/sig/ont/fma/fma84371"},{"id":"A506","pred":"fma_id","subj":"T506","obj":"http://purl.org/sig/ont/fma/fma68646"}],"text":"These analyses suggested that Immunotype 1, comprised of robust CD4 T cell activation, paucity of cTfh with proliferating effector/exhausted CD8 T cells and T-bet+ PB involvement, was connected to more severe disease whereas Immunotype 2, characterized by more traditional effector CD8 T cells subsets, less CD4 T cell activation and proliferating PB and memory B cells, was better captured by UMAP Component 2."}

{"project":"LitCovid-PubTator","denotations":[{"id":"1911","span":{"begin":64,"end":67},"obj":"Gene"},{"id":"1912","span":{"begin":141,"end":144},"obj":"Gene"},{"id":"1913","span":{"begin":157,"end":162},"obj":"Gene"},{"id":"1914","span":{"begin":282,"end":285},"obj":"Gene"},{"id":"1915","span":{"begin":308,"end":311},"obj":"Gene"},{"id":"1922","span":{"begin":98,"end":102},"obj":"Chemical"}],"attributes":[{"id":"A1911","pred":"tao:has_database_id","subj":"1911","obj":"Gene:920"},{"id":"A1912","pred":"tao:has_database_id","subj":"1912","obj":"Gene:925"},{"id":"A1913","pred":"tao:has_database_id","subj":"1913","obj":"Gene:30009"},{"id":"A1914","pred":"tao:has_database_id","subj":"1914","obj":"Gene:925"},{"id":"A1915","pred":"tao:has_database_id","subj":"1915","obj":"Gene:920"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"These analyses suggested that Immunotype 1, comprised of robust CD4 T cell activation, paucity of cTfh with proliferating effector/exhausted CD8 T cells and T-bet+ PB involvement, was connected to more severe disease whereas Immunotype 2, characterized by more traditional effector CD8 T cells subsets, less CD4 T cell activation and proliferating PB and memory B cells, was better captured by UMAP Component 2."}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T403","span":{"begin":164,"end":166},"obj":"Disease"},{"id":"T404","span":{"begin":348,"end":350},"obj":"Disease"}],"attributes":[{"id":"A403","pred":"mondo_id","subj":"T403","obj":"http://purl.obolibrary.org/obo/MONDO_0019035"},{"id":"A404","pred":"mondo_id","subj":"T404","obj":"http://purl.obolibrary.org/obo/MONDO_0019035"}],"text":"These analyses suggested that Immunotype 1, comprised of robust CD4 T cell activation, paucity of cTfh with proliferating effector/exhausted CD8 T cells and T-bet+ PB involvement, was connected to more severe disease whereas Immunotype 2, characterized by more traditional effector CD8 T cells subsets, less CD4 T cell activation and proliferating PB and memory B cells, was better captured by UMAP Component 2."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T905","span":{"begin":64,"end":67},"obj":"http://purl.obolibrary.org/obo/PR_000001004"},{"id":"T906","span":{"begin":68,"end":74},"obj":"http://purl.obolibrary.org/obo/CL_0000084"},{"id":"T907","span":{"begin":75,"end":85},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T908","span":{"begin":141,"end":144},"obj":"http://purl.obolibrary.org/obo/CLO_0053438"},{"id":"T909","span":{"begin":145,"end":152},"obj":"http://purl.obolibrary.org/obo/CL_0000084"},{"id":"T910","span":{"begin":282,"end":285},"obj":"http://purl.obolibrary.org/obo/CLO_0053438"},{"id":"T911","span":{"begin":286,"end":293},"obj":"http://purl.obolibrary.org/obo/CL_0000084"},{"id":"T912","span":{"begin":308,"end":311},"obj":"http://purl.obolibrary.org/obo/PR_000001004"},{"id":"T913","span":{"begin":312,"end":318},"obj":"http://purl.obolibrary.org/obo/CL_0000084"},{"id":"T914","span":{"begin":319,"end":329},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T915","span":{"begin":362,"end":369},"obj":"http://purl.obolibrary.org/obo/CL_0000236"}],"text":"These analyses suggested that Immunotype 1, comprised of robust CD4 T cell activation, paucity of cTfh with proliferating effector/exhausted CD8 T cells and T-bet+ PB involvement, was connected to more severe disease whereas Immunotype 2, characterized by more traditional effector CD8 T cells subsets, less CD4 T cell activation and proliferating PB and memory B cells, was better captured by UMAP Component 2."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T14749","span":{"begin":122,"end":130},"obj":"Chemical"},{"id":"T88670","span":{"begin":164,"end":166},"obj":"Chemical"},{"id":"T44023","span":{"begin":273,"end":281},"obj":"Chemical"},{"id":"T55913","span":{"begin":348,"end":350},"obj":"Chemical"}],"attributes":[{"id":"A89351","pred":"chebi_id","subj":"T14749","obj":"http://purl.obolibrary.org/obo/CHEBI_35224"},{"id":"A19091","pred":"chebi_id","subj":"T88670","obj":"http://purl.obolibrary.org/obo/CHEBI_53319"},{"id":"A26484","pred":"chebi_id","subj":"T88670","obj":"http://purl.obolibrary.org/obo/CHEBI_60686"},{"id":"A8109","pred":"chebi_id","subj":"T44023","obj":"http://purl.obolibrary.org/obo/CHEBI_35224"},{"id":"A76694","pred":"chebi_id","subj":"T55913","obj":"http://purl.obolibrary.org/obo/CHEBI_53319"},{"id":"A95506","pred":"chebi_id","subj":"T55913","obj":"http://purl.obolibrary.org/obo/CHEBI_60686"}],"text":"These analyses suggested that Immunotype 1, comprised of robust CD4 T cell activation, paucity of cTfh with proliferating effector/exhausted CD8 T cells and T-bet+ PB involvement, was connected to more severe disease whereas Immunotype 2, characterized by more traditional effector CD8 T cells subsets, less CD4 T cell activation and proliferating PB and memory B cells, was better captured by UMAP Component 2."}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T121","span":{"begin":68,"end":85},"obj":"http://purl.obolibrary.org/obo/GO_0042110"},{"id":"T122","span":{"begin":70,"end":85},"obj":"http://purl.obolibrary.org/obo/GO_0001775"},{"id":"T123","span":{"begin":312,"end":329},"obj":"http://purl.obolibrary.org/obo/GO_0042110"},{"id":"T124","span":{"begin":314,"end":329},"obj":"http://purl.obolibrary.org/obo/GO_0001775"},{"id":"T125","span":{"begin":355,"end":361},"obj":"http://purl.obolibrary.org/obo/GO_0007613"}],"text":"These analyses suggested that Immunotype 1, comprised of robust CD4 T cell activation, paucity of cTfh with proliferating effector/exhausted CD8 T cells and T-bet+ PB involvement, was connected to more severe disease whereas Immunotype 2, characterized by more traditional effector CD8 T cells subsets, less CD4 T cell activation and proliferating PB and memory B cells, was better captured by UMAP Component 2."}

{"project":"LitCovid-sentences","denotations":[{"id":"T347","span":{"begin":0,"end":411},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"These analyses suggested that Immunotype 1, comprised of robust CD4 T cell activation, paucity of cTfh with proliferating effector/exhausted CD8 T cells and T-bet+ PB involvement, was connected to more severe disease whereas Immunotype 2, characterized by more traditional effector CD8 T cells subsets, less CD4 T cell activation and proliferating PB and memory B cells, was better captured by UMAP Component 2."}