PMC:7402624 / 4846-5754 JSONTXT

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T30","span":{"begin":222,"end":227},"obj":"Body_part"},{"id":"T31","span":{"begin":390,"end":395},"obj":"Body_part"}],"attributes":[{"id":"A30","pred":"fma_id","subj":"T30","obj":"http://purl.org/sig/ont/fma/fma9670"},{"id":"A31","pred":"fma_id","subj":"T31","obj":"http://purl.org/sig/ont/fma/fma9670"}],"text":"We conducted an observational study of hospitalized patients with COVID-19 at the University of Pennsylvania (UPenn IRB 808542) that included 149 hospitalized adults with confirmed SARS-CoV2 infection (COVID-19 patients). Blood was collected at enrollment (typically ~24-72 hours after admission; Fig. 1A). Additional samples were obtained from patients who remained hospitalized on day 7. Blood was also collected from non-hospitalized patients who had recovered from documented SARS-CoV2 infection (Recovered Donors (RD); n = 46), as well as from healthy donors (HD; n = 70) (UPenn IRB 834263) (Fig. 1A). Clinical metadata are available from the COVID-19 patients over the course of disease (table S1). Of the total patients and donors, flow cytometry data from PBMCs was collected from COVID-19 patients (n = 125), RDs (n = 36), and HDs (n = 60) along with clinical metadata (Fig. 1A and tables S2 to S4)."}

{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T2","span":{"begin":222,"end":227},"obj":"Body_part"},{"id":"T3","span":{"begin":390,"end":395},"obj":"Body_part"}],"attributes":[{"id":"A2","pred":"uberon_id","subj":"T2","obj":"http://purl.obolibrary.org/obo/UBERON_0000178"},{"id":"A3","pred":"uberon_id","subj":"T3","obj":"http://purl.obolibrary.org/obo/UBERON_0000178"}],"text":"We conducted an observational study of hospitalized patients with COVID-19 at the University of Pennsylvania (UPenn IRB 808542) that included 149 hospitalized adults with confirmed SARS-CoV2 infection (COVID-19 patients). Blood was collected at enrollment (typically ~24-72 hours after admission; Fig. 1A). Additional samples were obtained from patients who remained hospitalized on day 7. Blood was also collected from non-hospitalized patients who had recovered from documented SARS-CoV2 infection (Recovered Donors (RD); n = 46), as well as from healthy donors (HD; n = 70) (UPenn IRB 834263) (Fig. 1A). Clinical metadata are available from the COVID-19 patients over the course of disease (table S1). Of the total patients and donors, flow cytometry data from PBMCs was collected from COVID-19 patients (n = 125), RDs (n = 36), and HDs (n = 60) along with clinical metadata (Fig. 1A and tables S2 to S4)."}

{"project":"LitCovid-PubTator","denotations":[{"id":"129","span":{"begin":52,"end":60},"obj":"Species"},{"id":"130","span":{"begin":181,"end":190},"obj":"Species"},{"id":"131","span":{"begin":211,"end":219},"obj":"Species"},{"id":"132","span":{"begin":345,"end":353},"obj":"Species"},{"id":"133","span":{"begin":437,"end":445},"obj":"Species"},{"id":"134","span":{"begin":480,"end":489},"obj":"Species"},{"id":"135","span":{"begin":657,"end":665},"obj":"Species"},{"id":"136","span":{"begin":718,"end":726},"obj":"Species"},{"id":"137","span":{"begin":798,"end":806},"obj":"Species"},{"id":"138","span":{"begin":66,"end":74},"obj":"Disease"},{"id":"139","span":{"begin":191,"end":200},"obj":"Disease"},{"id":"140","span":{"begin":202,"end":210},"obj":"Disease"},{"id":"141","span":{"begin":490,"end":499},"obj":"Disease"},{"id":"142","span":{"begin":565,"end":567},"obj":"Disease"},{"id":"143","span":{"begin":648,"end":656},"obj":"Disease"},{"id":"144","span":{"begin":789,"end":797},"obj":"Disease"},{"id":"145","span":{"begin":836,"end":839},"obj":"Disease"}],"attributes":[{"id":"A129","pred":"tao:has_database_id","subj":"129","obj":"Tax:9606"},{"id":"A130","pred":"tao:has_database_id","subj":"130","obj":"Tax:2697049"},{"id":"A131","pred":"tao:has_database_id","subj":"131","obj":"Tax:9606"},{"id":"A132","pred":"tao:has_database_id","subj":"132","obj":"Tax:9606"},{"id":"A133","pred":"tao:has_database_id","subj":"133","obj":"Tax:9606"},{"id":"A134","pred":"tao:has_database_id","subj":"134","obj":"Tax:2697049"},{"id":"A135","pred":"tao:has_database_id","subj":"135","obj":"Tax:9606"},{"id":"A136","pred":"tao:has_database_id","subj":"136","obj":"Tax:9606"},{"id":"A137","pred":"tao:has_database_id","subj":"137","obj":"Tax:9606"},{"id":"A138","pred":"tao:has_database_id","subj":"138","obj":"MESH:C000657245"},{"id":"A139","pred":"tao:has_database_id","subj":"139","obj":"MESH:D007239"},{"id":"A140","pred":"tao:has_database_id","subj":"140","obj":"MESH:C000657245"},{"id":"A141","pred":"tao:has_database_id","subj":"141","obj":"MESH:D007239"},{"id":"A142","pred":"tao:has_database_id","subj":"142","obj":"MESH:D006816"},{"id":"A143","pred":"tao:has_database_id","subj":"143","obj":"MESH:C000657245"},{"id":"A144","pred":"tao:has_database_id","subj":"144","obj":"MESH:C000657245"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"We conducted an observational study of hospitalized patients with COVID-19 at the University of Pennsylvania (UPenn IRB 808542) that included 149 hospitalized adults with confirmed SARS-CoV2 infection (COVID-19 patients). Blood was collected at enrollment (typically ~24-72 hours after admission; Fig. 1A). Additional samples were obtained from patients who remained hospitalized on day 7. Blood was also collected from non-hospitalized patients who had recovered from documented SARS-CoV2 infection (Recovered Donors (RD); n = 46), as well as from healthy donors (HD; n = 70) (UPenn IRB 834263) (Fig. 1A). Clinical metadata are available from the COVID-19 patients over the course of disease (table S1). Of the total patients and donors, flow cytometry data from PBMCs was collected from COVID-19 patients (n = 125), RDs (n = 36), and HDs (n = 60) along with clinical metadata (Fig. 1A and tables S2 to S4)."}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T35","span":{"begin":66,"end":74},"obj":"Disease"},{"id":"T36","span":{"begin":181,"end":185},"obj":"Disease"},{"id":"T37","span":{"begin":191,"end":200},"obj":"Disease"},{"id":"T38","span":{"begin":202,"end":210},"obj":"Disease"},{"id":"T39","span":{"begin":480,"end":484},"obj":"Disease"},{"id":"T40","span":{"begin":490,"end":499},"obj":"Disease"},{"id":"T41","span":{"begin":519,"end":521},"obj":"Disease"},{"id":"T42","span":{"begin":565,"end":567},"obj":"Disease"},{"id":"T43","span":{"begin":648,"end":656},"obj":"Disease"},{"id":"T44","span":{"begin":789,"end":797},"obj":"Disease"}],"attributes":[{"id":"A35","pred":"mondo_id","subj":"T35","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A36","pred":"mondo_id","subj":"T36","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A37","pred":"mondo_id","subj":"T37","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A38","pred":"mondo_id","subj":"T38","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A39","pred":"mondo_id","subj":"T39","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A40","pred":"mondo_id","subj":"T40","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A41","pred":"mondo_id","subj":"T41","obj":"http://purl.obolibrary.org/obo/MONDO_0009973"},{"id":"A42","pred":"mondo_id","subj":"T42","obj":"http://purl.obolibrary.org/obo/MONDO_0007739"},{"id":"A43","pred":"mondo_id","subj":"T43","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A44","pred":"mondo_id","subj":"T44","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"}],"text":"We conducted an observational study of hospitalized patients with COVID-19 at the University of Pennsylvania (UPenn IRB 808542) that included 149 hospitalized adults with confirmed SARS-CoV2 infection (COVID-19 patients). Blood was collected at enrollment (typically ~24-72 hours after admission; Fig. 1A). Additional samples were obtained from patients who remained hospitalized on day 7. Blood was also collected from non-hospitalized patients who had recovered from documented SARS-CoV2 infection (Recovered Donors (RD); n = 46), as well as from healthy donors (HD; n = 70) (UPenn IRB 834263) (Fig. 1A). Clinical metadata are available from the COVID-19 patients over the course of disease (table S1). Of the total patients and donors, flow cytometry data from PBMCs was collected from COVID-19 patients (n = 125), RDs (n = 36), and HDs (n = 60) along with clinical metadata (Fig. 1A and tables S2 to S4)."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T51","span":{"begin":222,"end":227},"obj":"http://purl.obolibrary.org/obo/UBERON_0000178"},{"id":"T52","span":{"begin":222,"end":227},"obj":"http://www.ebi.ac.uk/efo/EFO_0000296"},{"id":"T53","span":{"begin":390,"end":395},"obj":"http://purl.obolibrary.org/obo/UBERON_0000178"},{"id":"T54","span":{"begin":390,"end":395},"obj":"http://www.ebi.ac.uk/efo/EFO_0000296"},{"id":"T55","span":{"begin":519,"end":521},"obj":"http://purl.obolibrary.org/obo/CLO_0008770"},{"id":"T56","span":{"begin":700,"end":702},"obj":"http://purl.obolibrary.org/obo/CLO_0050050"},{"id":"T57","span":{"begin":827,"end":829},"obj":"http://purl.obolibrary.org/obo/CLO_0001313"},{"id":"T58","span":{"begin":898,"end":900},"obj":"http://purl.obolibrary.org/obo/CLO_0008922"},{"id":"T59","span":{"begin":898,"end":900},"obj":"http://purl.obolibrary.org/obo/CLO_0050052"}],"text":"We conducted an observational study of hospitalized patients with COVID-19 at the University of Pennsylvania (UPenn IRB 808542) that included 149 hospitalized adults with confirmed SARS-CoV2 infection (COVID-19 patients). Blood was collected at enrollment (typically ~24-72 hours after admission; Fig. 1A). Additional samples were obtained from patients who remained hospitalized on day 7. Blood was also collected from non-hospitalized patients who had recovered from documented SARS-CoV2 infection (Recovered Donors (RD); n = 46), as well as from healthy donors (HD; n = 70) (UPenn IRB 834263) (Fig. 1A). Clinical metadata are available from the COVID-19 patients over the course of disease (table S1). Of the total patients and donors, flow cytometry data from PBMCs was collected from COVID-19 patients (n = 125), RDs (n = 36), and HDs (n = 60) along with clinical metadata (Fig. 1A and tables S2 to S4)."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T10","span":{"begin":519,"end":521},"obj":"Chemical"},{"id":"T11","span":{"begin":565,"end":567},"obj":"Chemical"},{"id":"T12","span":{"begin":898,"end":900},"obj":"Chemical"},{"id":"T13","span":{"begin":904,"end":906},"obj":"Chemical"}],"attributes":[{"id":"A10","pred":"chebi_id","subj":"T10","obj":"http://purl.obolibrary.org/obo/CHEBI_73812"},{"id":"A11","pred":"chebi_id","subj":"T11","obj":"http://purl.obolibrary.org/obo/CHEBI_73925"},{"id":"A12","pred":"chebi_id","subj":"T12","obj":"http://purl.obolibrary.org/obo/CHEBI_29387"},{"id":"A13","pred":"chebi_id","subj":"T13","obj":"http://purl.obolibrary.org/obo/CHEBI_29401"}],"text":"We conducted an observational study of hospitalized patients with COVID-19 at the University of Pennsylvania (UPenn IRB 808542) that included 149 hospitalized adults with confirmed SARS-CoV2 infection (COVID-19 patients). Blood was collected at enrollment (typically ~24-72 hours after admission; Fig. 1A). Additional samples were obtained from patients who remained hospitalized on day 7. Blood was also collected from non-hospitalized patients who had recovered from documented SARS-CoV2 infection (Recovered Donors (RD); n = 46), as well as from healthy donors (HD; n = 70) (UPenn IRB 834263) (Fig. 1A). Clinical metadata are available from the COVID-19 patients over the course of disease (table S1). Of the total patients and donors, flow cytometry data from PBMCs was collected from COVID-19 patients (n = 125), RDs (n = 36), and HDs (n = 60) along with clinical metadata (Fig. 1A and tables S2 to S4)."}

{"project":"LitCovid-sentences","denotations":[{"id":"T35","span":{"begin":0,"end":221},"obj":"Sentence"},{"id":"T36","span":{"begin":222,"end":306},"obj":"Sentence"},{"id":"T37","span":{"begin":307,"end":389},"obj":"Sentence"},{"id":"T38","span":{"begin":390,"end":606},"obj":"Sentence"},{"id":"T39","span":{"begin":607,"end":704},"obj":"Sentence"},{"id":"T40","span":{"begin":705,"end":908},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"We conducted an observational study of hospitalized patients with COVID-19 at the University of Pennsylvania (UPenn IRB 808542) that included 149 hospitalized adults with confirmed SARS-CoV2 infection (COVID-19 patients). Blood was collected at enrollment (typically ~24-72 hours after admission; Fig. 1A). Additional samples were obtained from patients who remained hospitalized on day 7. Blood was also collected from non-hospitalized patients who had recovered from documented SARS-CoV2 infection (Recovered Donors (RD); n = 46), as well as from healthy donors (HD; n = 70) (UPenn IRB 834263) (Fig. 1A). Clinical metadata are available from the COVID-19 patients over the course of disease (table S1). Of the total patients and donors, flow cytometry data from PBMCs was collected from COVID-19 patients (n = 125), RDs (n = 36), and HDs (n = 60) along with clinical metadata (Fig. 1A and tables S2 to S4)."}