PMC:7402624 / 44085-45165
Annnotations
LitCovid-PD-FMA-UBERON
Id | Subject | Object | Predicate | Lexical cue | fma_id |
---|---|---|---|---|---|
T391 | 391-395 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
T392 | 692-696 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
T393 | 742-746 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
T394 | 754-758 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
T395 | 765-769 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
T396 | 977-982 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
T397 | 1007-1011 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
LitCovid-PubTator
Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
---|---|---|---|---|---|
1521 | 736-739 | Gene | denotes | CD8 | Gene:925 |
1522 | 748-751 | Gene | denotes | CD4 | Gene:920 |
1523 | 103-110 | Species | denotes | patient | Tax:9606 |
1524 | 589-596 | Species | denotes | patient | Tax:9606 |
1525 | 631-639 | Species | denotes | patients | Tax:9606 |
1526 | 818-825 | Species | denotes | patient | Tax:9606 |
1527 | 927-935 | Species | denotes | patients | Tax:9606 |
1528 | 1046-1054 | Species | denotes | patients | Tax:9606 |
1529 | 918-926 | Disease | denotes | COVID-19 | MESH:C000657245 |
LitCovid-PD-MONDO
Id | Subject | Object | Predicate | Lexical cue | mondo_id |
---|---|---|---|---|---|
T325 | 918-926 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
LitCovid-PD-CLO
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T713 | 389-395 | http://purl.obolibrary.org/obo/CL_0000236 | denotes | B cell |
T714 | 690-696 | http://purl.obolibrary.org/obo/CL_0000236 | denotes | B cell |
T715 | 736-739 | http://purl.obolibrary.org/obo/CLO_0053438 | denotes | CD8 |
T716 | 740-746 | http://purl.obolibrary.org/obo/CL_0000084 | denotes | T cell |
T717 | 748-751 | http://purl.obolibrary.org/obo/PR_000001004 | denotes | CD4 |
T718 | 752-758 | http://purl.obolibrary.org/obo/CL_0000084 | denotes | T cell |
T719 | 763-769 | http://purl.obolibrary.org/obo/CL_0000236 | denotes | B cell |
T720 | 797-798 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T721 | 975-982 | http://purl.obolibrary.org/obo/CL_0000236 | denotes | B cells |
T722 | 1007-1017 | http://purl.obolibrary.org/obo/CL_0000000 | denotes | cell types |
LitCovid-PD-CHEBI
Id | Subject | Object | Predicate | Lexical cue | chebi_id |
---|---|---|---|---|---|
T303 | 470-472 | Chemical | denotes | 6C | http://purl.obolibrary.org/obo/CHEBI_27594 |
T304 | 715-717 | Chemical | denotes | 6C | http://purl.obolibrary.org/obo/CHEBI_27594 |
LitCovid-sentences
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T251 | 0-66 | Sentence | denotes | There were two challenges with extracting meaning from these data. |
T252 | 67-193 | Sentence | denotes | First, there was considerable inter-patient heterogeneity for each of these immune features related to disease severity score. |
T253 | 194-351 | Sentence | denotes | Second, these binary comparisons (e.g., one immune subset versus one clinical feature) vastly underutilized the high dimensional information in this dataset. |
T254 | 352-474 | Sentence | denotes | Thus, we next visualized major T and B cell subpopulation data as it related to clinical disease severity score (Fig. 6C). |
T255 | 475-597 | Sentence | denotes | Data were clustered based on immune features and then overlaid with the disease severity score over time for each patient. |
T256 | 598-719 | Sentence | denotes | This analysis revealed groups of patients with similar composite immune signatures of T and B cell populations (Fig. 6C). |
T257 | 720-867 | Sentence | denotes | When individual CD8 T cell, CD4 T cell, or B cell populations were examined, a similar concept of patient subgroups emerged (fig. S7, F, G, and H). |
T258 | 868-1080 | Sentence | denotes | These data suggested the idea of “immunotypes” of COVID-19 patients based on integrated responses of T and B cells, though some individual cell types and/or phenotypes separated patients more clearly than others. |