PMC:7402624 / 39188-41269
Annnotations
{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7402624","sourcedb":"PMC","sourceid":"7402624","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7402624","text":"We next asked whether these T and B cell dynamics related to clinical measures of COVID-19 disease, by correlating changes in immune features from D0 to D7 with clinical information (Fig. 5G). These analyses revealed distinct correlations. Decreases in all populations of responding CD4 and CD8 T cells (HLA-DR+CD38+, KI67+, or activated cTfh) between D0 and D7 were positively correlated with PMN and WBC counts, suggesting a relationship between T cell activation and lymphopenia. Furthermore, decreases in CD4 and CD8 HLA-DR+CD38+ T cells positively correlated with APACHE III score. However, stable HLA-DR+CD38+ CD4 T cell responses correlated with coagulation complications and ferritin. Whereas decreasing activated cTfh over time was related to co-infection, the opposite pattern was observed for PB. Increases in proliferating KI67+ CD4 and CD8 T cells over time were positively correlated to increasing anti-SARS-CoV2 antibody from day 0 to day 7, suggesting that some individuals might have been hospitalized during the expansion phase of the antiviral immune response (Fig. 5G). Finally, neither Remdesivir nor HCQ treatment correlated with any of these immune features in Fig. 5G). Examining categorical rather than continuous clinical data, 80% of patients with decreasing PB over time had hyperlipidemia, whereas only 20% of patients with increasing PB over time had this comorbidity (fig. S6D). All patients who had decreasing CD38+HLA-DR+ CD8 T cells from day 0 to day 7 were treated with early vasoactive medication or inhaled nitric oxide whereas these treatments were less common for patients with stable or increasing CD38+HLA-DR+ CD8 T cells (fig. S6E). In contrast, vasoactive medication, inhaled nitric oxide, and early steroid treatment were equally common in patients with increasing or decreasing PB (fig. S6D). Similar patterns were apparent for other T cell populations and these categorical clinical data (fig. S6F). Thus, the trajectory of change in the T and B cell response in COVID-19 patients was strongly connected to clinical metrics of disease.","tracks":[{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T360","span":{"begin":36,"end":40},"obj":"Body_part"},{"id":"T361","span":{"begin":297,"end":302},"obj":"Body_part"},{"id":"T362","span":{"begin":304,"end":307},"obj":"Body_part"},{"id":"T363","span":{"begin":450,"end":454},"obj":"Body_part"},{"id":"T364","span":{"begin":521,"end":524},"obj":"Body_part"},{"id":"T365","span":{"begin":536,"end":541},"obj":"Body_part"},{"id":"T366","span":{"begin":603,"end":606},"obj":"Body_part"},{"id":"T367","span":{"begin":622,"end":626},"obj":"Body_part"},{"id":"T368","span":{"begin":804,"end":806},"obj":"Body_part"},{"id":"T369","span":{"begin":855,"end":860},"obj":"Body_part"},{"id":"T370","span":{"begin":927,"end":935},"obj":"Body_part"},{"id":"T371","span":{"begin":1286,"end":1288},"obj":"Body_part"},{"id":"T372","span":{"begin":1364,"end":1366},"obj":"Body_part"},{"id":"T373","span":{"begin":1447,"end":1450},"obj":"Body_part"},{"id":"T374","span":{"begin":1461,"end":1466},"obj":"Body_part"},{"id":"T375","span":{"begin":1643,"end":1646},"obj":"Body_part"},{"id":"T376","span":{"begin":1657,"end":1662},"obj":"Body_part"},{"id":"T377","span":{"begin":1823,"end":1825},"obj":"Body_part"},{"id":"T378","span":{"begin":1881,"end":1885},"obj":"Body_part"},{"id":"T379","span":{"begin":1992,"end":1996},"obj":"Body_part"}],"attributes":[{"id":"A360","pred":"fma_id","subj":"T360","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A361","pred":"fma_id","subj":"T361","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A362","pred":"fma_id","subj":"T362","obj":"http://purl.org/sig/ont/fma/fma84795"},{"id":"A363","pred":"fma_id","subj":"T363","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A364","pred":"fma_id","subj":"T364","obj":"http://purl.org/sig/ont/fma/fma84795"},{"id":"A365","pred":"fma_id","subj":"T365","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A366","pred":"fma_id","subj":"T366","obj":"http://purl.org/sig/ont/fma/fma84795"},{"id":"A367","pred":"fma_id","subj":"T367","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A368","pred":"fma_id","subj":"T368","obj":"http://purl.org/sig/ont/fma/fma84371"},{"id":"A369","pred":"fma_id","subj":"T369","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A370","pred":"fma_id","subj":"T370","obj":"http://purl.org/sig/ont/fma/fma62871"},{"id":"A371","pred":"fma_id","subj":"T371","obj":"http://purl.org/sig/ont/fma/fma84371"},{"id":"A372","pred":"fma_id","subj":"T372","obj":"http://purl.org/sig/ont/fma/fma84371"},{"id":"A373","pred":"fma_id","subj":"T373","obj":"http://purl.org/sig/ont/fma/fma84795"},{"id":"A374","pred":"fma_id","subj":"T374","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A375","pred":"fma_id","subj":"T375","obj":"http://purl.org/sig/ont/fma/fma84795"},{"id":"A376","pred":"fma_id","subj":"T376","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A377","pred":"fma_id","subj":"T377","obj":"http://purl.org/sig/ont/fma/fma84371"},{"id":"A378","pred":"fma_id","subj":"T378","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A379","pred":"fma_id","subj":"T379","obj":"http://purl.org/sig/ont/fma/fma68646"},{"subj":"T360","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T361","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T362","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T363","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T364","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T365","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T366","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T367","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T368","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T369","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T370","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T371","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T372","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T373","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T374","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T375","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T376","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T377","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T378","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T379","pred":"source","obj":"LitCovid-PD-FMA-UBERON"}]},{"project":"LitCovid-PubTator","denotations":[{"id":"1421","span":{"begin":283,"end":286},"obj":"Gene"},{"id":"1422","span":{"begin":291,"end":294},"obj":"Gene"},{"id":"1423","span":{"begin":311,"end":315},"obj":"Gene"},{"id":"1424","span":{"begin":509,"end":512},"obj":"Gene"},{"id":"1425","span":{"begin":517,"end":520},"obj":"Gene"},{"id":"1426","span":{"begin":528,"end":532},"obj":"Gene"},{"id":"1427","span":{"begin":610,"end":614},"obj":"Gene"},{"id":"1428","span":{"begin":616,"end":619},"obj":"Gene"},{"id":"1429","span":{"begin":841,"end":844},"obj":"Gene"},{"id":"1430","span":{"begin":1442,"end":1446},"obj":"Gene"},{"id":"1431","span":{"begin":1455,"end":1458},"obj":"Gene"},{"id":"1432","span":{"begin":1638,"end":1642},"obj":"Gene"},{"id":"1433","span":{"begin":1651,"end":1654},"obj":"Gene"},{"id":"1434","span":{"begin":849,"end":852},"obj":"Gene"},{"id":"1435","span":{"begin":1261,"end":1269},"obj":"Species"},{"id":"1436","span":{"begin":1339,"end":1347},"obj":"Species"},{"id":"1437","span":{"begin":1414,"end":1422},"obj":"Species"},{"id":"1438","span":{"begin":1603,"end":1611},"obj":"Species"},{"id":"1439","span":{"begin":1784,"end":1792},"obj":"Species"},{"id":"1440","span":{"begin":2018,"end":2026},"obj":"Species"},{"id":"1441","span":{"begin":917,"end":926},"obj":"Species"},{"id":"1442","span":{"begin":722,"end":726},"obj":"Chemical"},{"id":"1443","span":{"begin":1107,"end":1117},"obj":"Chemical"},{"id":"1444","span":{"begin":1122,"end":1125},"obj":"Chemical"},{"id":"1445","span":{"begin":1286,"end":1288},"obj":"Chemical"},{"id":"1446","span":{"begin":1364,"end":1366},"obj":"Chemical"},{"id":"1447","span":{"begin":1544,"end":1556},"obj":"Chemical"},{"id":"1448","span":{"begin":1719,"end":1731},"obj":"Chemical"},{"id":"1449","span":{"begin":1743,"end":1750},"obj":"Chemical"},{"id":"1450","span":{"begin":82,"end":90},"obj":"Disease"},{"id":"1451","span":{"begin":470,"end":481},"obj":"Disease"},{"id":"1452","span":{"begin":653,"end":678},"obj":"Disease"},{"id":"1453","span":{"begin":752,"end":764},"obj":"Disease"},{"id":"1454","span":{"begin":1303,"end":1317},"obj":"Disease"},{"id":"1455","span":{"begin":2009,"end":2017},"obj":"Disease"}],"attributes":[{"id":"A1421","pred":"tao:has_database_id","subj":"1421","obj":"Gene:920"},{"id":"A1422","pred":"tao:has_database_id","subj":"1422","obj":"Gene:925"},{"id":"A1423","pred":"tao:has_database_id","subj":"1423","obj":"Gene:952"},{"id":"A1424","pred":"tao:has_database_id","subj":"1424","obj":"Gene:920"},{"id":"A1425","pred":"tao:has_database_id","subj":"1425","obj":"Gene:925"},{"id":"A1426","pred":"tao:has_database_id","subj":"1426","obj":"Gene:952"},{"id":"A1427","pred":"tao:has_database_id","subj":"1427","obj":"Gene:952"},{"id":"A1428","pred":"tao:has_database_id","subj":"1428","obj":"Gene:920"},{"id":"A1429","pred":"tao:has_database_id","subj":"1429","obj":"Gene:920"},{"id":"A1430","pred":"tao:has_database_id","subj":"1430","obj":"Gene:952"},{"id":"A1431","pred":"tao:has_database_id","subj":"1431","obj":"Gene:925"},{"id":"A1432","pred":"tao:has_database_id","subj":"1432","obj":"Gene:952"},{"id":"A1433","pred":"tao:has_database_id","subj":"1433","obj":"Gene:925"},{"id":"A1434","pred":"tao:has_database_id","subj":"1434","obj":"Gene:925"},{"id":"A1435","pred":"tao:has_database_id","subj":"1435","obj":"Tax:9606"},{"id":"A1436","pred":"tao:has_database_id","subj":"1436","obj":"Tax:9606"},{"id":"A1437","pred":"tao:has_database_id","subj":"1437","obj":"Tax:9606"},{"id":"A1438","pred":"tao:has_database_id","subj":"1438","obj":"Tax:9606"},{"id":"A1439","pred":"tao:has_database_id","subj":"1439","obj":"Tax:9606"},{"id":"A1440","pred":"tao:has_database_id","subj":"1440","obj":"Tax:9606"},{"id":"A1441","pred":"tao:has_database_id","subj":"1441","obj":"Tax:2697049"},{"id":"A1443","pred":"tao:has_database_id","subj":"1443","obj":"MESH:C000606551"},{"id":"A1444","pred":"tao:has_database_id","subj":"1444","obj":"MESH:D006886"},{"id":"A1447","pred":"tao:has_database_id","subj":"1447","obj":"MESH:D009569"},{"id":"A1448","pred":"tao:has_database_id","subj":"1448","obj":"MESH:D009569"},{"id":"A1449","pred":"tao:has_database_id","subj":"1449","obj":"MESH:D013256"},{"id":"A1450","pred":"tao:has_database_id","subj":"1450","obj":"MESH:C000657245"},{"id":"A1451","pred":"tao:has_database_id","subj":"1451","obj":"MESH:D008231"},{"id":"A1452","pred":"tao:has_database_id","subj":"1452","obj":"MESH:D001778"},{"id":"A1453","pred":"tao:has_database_id","subj":"1453","obj":"MESH:D060085"},{"id":"A1454","pred":"tao:has_database_id","subj":"1454","obj":"MESH:D006949"},{"id":"A1455","pred":"tao:has_database_id","subj":"1455","obj":"MESH:C000657245"},{"subj":"1421","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1422","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1423","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1424","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1425","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1426","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1427","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1428","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1429","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1430","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1431","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1432","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1433","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1434","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1435","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1436","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1437","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1438","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1439","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1440","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1441","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1442","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1443","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1444","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1445","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1446","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1447","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1448","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1449","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1450","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1451","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1452","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1453","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1454","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1455","pred":"source","obj":"LitCovid-PubTator"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}]},{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T306","span":{"begin":82,"end":90},"obj":"Disease"},{"id":"T307","span":{"begin":470,"end":481},"obj":"Disease"},{"id":"T308","span":{"begin":755,"end":764},"obj":"Disease"},{"id":"T309","span":{"begin":804,"end":806},"obj":"Disease"},{"id":"T310","span":{"begin":917,"end":921},"obj":"Disease"},{"id":"T311","span":{"begin":1286,"end":1288},"obj":"Disease"},{"id":"T312","span":{"begin":1303,"end":1317},"obj":"Disease"},{"id":"T313","span":{"begin":1364,"end":1366},"obj":"Disease"},{"id":"T314","span":{"begin":1823,"end":1825},"obj":"Disease"},{"id":"T315","span":{"begin":2009,"end":2017},"obj":"Disease"}],"attributes":[{"id":"A306","pred":"mondo_id","subj":"T306","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A307","pred":"mondo_id","subj":"T307","obj":"http://purl.obolibrary.org/obo/MONDO_0003783"},{"id":"A308","pred":"mondo_id","subj":"T308","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A309","pred":"mondo_id","subj":"T309","obj":"http://purl.obolibrary.org/obo/MONDO_0019035"},{"id":"A310","pred":"mondo_id","subj":"T310","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A311","pred":"mondo_id","subj":"T311","obj":"http://purl.obolibrary.org/obo/MONDO_0019035"},{"id":"A312","pred":"mondo_id","subj":"T312","obj":"http://purl.obolibrary.org/obo/MONDO_0021187"},{"id":"A313","pred":"mondo_id","subj":"T313","obj":"http://purl.obolibrary.org/obo/MONDO_0019035"},{"id":"A314","pred":"mondo_id","subj":"T314","obj":"http://purl.obolibrary.org/obo/MONDO_0019035"},{"id":"A315","pred":"mondo_id","subj":"T315","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"subj":"T306","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T307","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T308","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T309","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T310","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T311","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T312","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T313","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T314","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T315","pred":"source","obj":"LitCovid-PD-MONDO"}]},{"project":"LitCovid-PD-CLO","denotations":[{"id":"T660","span":{"begin":34,"end":40},"obj":"http://purl.obolibrary.org/obo/CL_0000236"},{"id":"T661","span":{"begin":283,"end":286},"obj":"http://purl.obolibrary.org/obo/PR_000001004"},{"id":"T662","span":{"begin":291,"end":294},"obj":"http://purl.obolibrary.org/obo/CLO_0053438"},{"id":"T663","span":{"begin":295,"end":302},"obj":"http://purl.obolibrary.org/obo/CL_0000084"},{"id":"T664","span":{"begin":311,"end":315},"obj":"http://purl.obolibrary.org/obo/PR_000001408"},{"id":"T665","span":{"begin":328,"end":337},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T666","span":{"begin":425,"end":426},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T667","span":{"begin":448,"end":454},"obj":"http://purl.obolibrary.org/obo/CL_0000084"},{"id":"T668","span":{"begin":455,"end":465},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T669","span":{"begin":509,"end":512},"obj":"http://purl.obolibrary.org/obo/PR_000001004"},{"id":"T670","span":{"begin":517,"end":520},"obj":"http://purl.obolibrary.org/obo/CLO_0053438"},{"id":"T671","span":{"begin":528,"end":532},"obj":"http://purl.obolibrary.org/obo/PR_000001408"},{"id":"T672","span":{"begin":534,"end":541},"obj":"http://purl.obolibrary.org/obo/CL_0000084"},{"id":"T673","span":{"begin":610,"end":614},"obj":"http://purl.obolibrary.org/obo/PR_000001408"},{"id":"T674","span":{"begin":616,"end":619},"obj":"http://purl.obolibrary.org/obo/PR_000001004"},{"id":"T675","span":{"begin":620,"end":626},"obj":"http://purl.obolibrary.org/obo/CL_0000084"},{"id":"T676","span":{"begin":712,"end":721},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T677","span":{"begin":841,"end":844},"obj":"http://purl.obolibrary.org/obo/PR_000001004"},{"id":"T678","span":{"begin":849,"end":852},"obj":"http://purl.obolibrary.org/obo/CLO_0053438"},{"id":"T679","span":{"begin":853,"end":860},"obj":"http://purl.obolibrary.org/obo/CL_0000084"},{"id":"T680","span":{"begin":1442,"end":1446},"obj":"http://purl.obolibrary.org/obo/PR_000001408"},{"id":"T681","span":{"begin":1455,"end":1458},"obj":"http://purl.obolibrary.org/obo/CLO_0053438"},{"id":"T682","span":{"begin":1459,"end":1466},"obj":"http://purl.obolibrary.org/obo/CL_0000084"},{"id":"T683","span":{"begin":1638,"end":1642},"obj":"http://purl.obolibrary.org/obo/PR_000001408"},{"id":"T684","span":{"begin":1651,"end":1654},"obj":"http://purl.obolibrary.org/obo/CLO_0053438"},{"id":"T685","span":{"begin":1655,"end":1662},"obj":"http://purl.obolibrary.org/obo/CL_0000084"},{"id":"T686","span":{"begin":1879,"end":1885},"obj":"http://purl.obolibrary.org/obo/CL_0000084"},{"id":"T687","span":{"begin":1990,"end":1996},"obj":"http://purl.obolibrary.org/obo/CL_0000236"}],"attributes":[{"subj":"T660","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T661","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T662","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T663","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T664","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T665","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T666","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T667","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T668","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T669","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T670","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T671","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T672","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T673","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T674","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T675","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T676","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T677","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T678","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T679","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T680","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T681","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T682","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T683","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T684","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T685","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T686","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T687","pred":"source","obj":"LitCovid-PD-CLO"}]},{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T272","span":{"begin":308,"end":310},"obj":"Chemical"},{"id":"T273","span":{"begin":525,"end":527},"obj":"Chemical"},{"id":"T274","span":{"begin":607,"end":609},"obj":"Chemical"},{"id":"T275","span":{"begin":804,"end":806},"obj":"Chemical"},{"id":"T277","span":{"begin":1053,"end":1062},"obj":"Chemical"},{"id":"T278","span":{"begin":1286,"end":1288},"obj":"Chemical"},{"id":"T280","span":{"begin":1364,"end":1366},"obj":"Chemical"},{"id":"T282","span":{"begin":1451,"end":1453},"obj":"Chemical"},{"id":"T283","span":{"begin":1544,"end":1556},"obj":"Chemical"},{"id":"T284","span":{"begin":1551,"end":1556},"obj":"Chemical"},{"id":"T286","span":{"begin":1647,"end":1649},"obj":"Chemical"},{"id":"T287","span":{"begin":1719,"end":1731},"obj":"Chemical"},{"id":"T288","span":{"begin":1726,"end":1731},"obj":"Chemical"},{"id":"T290","span":{"begin":1743,"end":1750},"obj":"Chemical"},{"id":"T291","span":{"begin":1823,"end":1825},"obj":"Chemical"}],"attributes":[{"id":"A272","pred":"chebi_id","subj":"T272","obj":"http://purl.obolibrary.org/obo/CHEBI_73445"},{"id":"A273","pred":"chebi_id","subj":"T273","obj":"http://purl.obolibrary.org/obo/CHEBI_73445"},{"id":"A274","pred":"chebi_id","subj":"T274","obj":"http://purl.obolibrary.org/obo/CHEBI_73445"},{"id":"A275","pred":"chebi_id","subj":"T275","obj":"http://purl.obolibrary.org/obo/CHEBI_53319"},{"id":"A276","pred":"chebi_id","subj":"T275","obj":"http://purl.obolibrary.org/obo/CHEBI_60686"},{"id":"A277","pred":"chebi_id","subj":"T277","obj":"http://purl.obolibrary.org/obo/CHEBI_22587"},{"id":"A278","pred":"chebi_id","subj":"T278","obj":"http://purl.obolibrary.org/obo/CHEBI_53319"},{"id":"A279","pred":"chebi_id","subj":"T278","obj":"http://purl.obolibrary.org/obo/CHEBI_60686"},{"id":"A280","pred":"chebi_id","subj":"T280","obj":"http://purl.obolibrary.org/obo/CHEBI_53319"},{"id":"A281","pred":"chebi_id","subj":"T280","obj":"http://purl.obolibrary.org/obo/CHEBI_60686"},{"id":"A282","pred":"chebi_id","subj":"T282","obj":"http://purl.obolibrary.org/obo/CHEBI_73445"},{"id":"A283","pred":"chebi_id","subj":"T283","obj":"http://purl.obolibrary.org/obo/CHEBI_16480"},{"id":"A284","pred":"chebi_id","subj":"T284","obj":"http://purl.obolibrary.org/obo/CHEBI_25741"},{"id":"A285","pred":"chebi_id","subj":"T284","obj":"http://purl.obolibrary.org/obo/CHEBI_29356"},{"id":"A286","pred":"chebi_id","subj":"T286","obj":"http://purl.obolibrary.org/obo/CHEBI_73445"},{"id":"A287","pred":"chebi_id","subj":"T287","obj":"http://purl.obolibrary.org/obo/CHEBI_16480"},{"id":"A288","pred":"chebi_id","subj":"T288","obj":"http://purl.obolibrary.org/obo/CHEBI_25741"},{"id":"A289","pred":"chebi_id","subj":"T288","obj":"http://purl.obolibrary.org/obo/CHEBI_29356"},{"id":"A290","pred":"chebi_id","subj":"T290","obj":"http://purl.obolibrary.org/obo/CHEBI_35341"},{"id":"A291","pred":"chebi_id","subj":"T291","obj":"http://purl.obolibrary.org/obo/CHEBI_53319"},{"id":"A292","pred":"chebi_id","subj":"T291","obj":"http://purl.obolibrary.org/obo/CHEBI_60686"},{"subj":"T272","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T273","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T274","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T275","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T277","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T278","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T280","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T282","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T283","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T284","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T286","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T287","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T288","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T290","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T291","pred":"source","obj":"LitCovid-PD-CHEBI"}]},{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T85","span":{"begin":448,"end":465},"obj":"http://purl.obolibrary.org/obo/GO_0042110"},{"id":"T86","span":{"begin":450,"end":465},"obj":"http://purl.obolibrary.org/obo/GO_0001775"},{"id":"T87","span":{"begin":653,"end":664},"obj":"http://purl.obolibrary.org/obo/GO_0050817"},{"id":"T88","span":{"begin":1063,"end":1078},"obj":"http://purl.obolibrary.org/obo/GO_0006955"}],"attributes":[{"subj":"T85","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T86","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T87","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T88","pred":"source","obj":"LitCovid-PD-GO-BP"}]},{"project":"LitCovid-PD-HP","denotations":[{"id":"T11","span":{"begin":470,"end":481},"obj":"Phenotype"},{"id":"T12","span":{"begin":1303,"end":1317},"obj":"Phenotype"}],"attributes":[{"id":"A11","pred":"hp_id","subj":"T11","obj":"http://purl.obolibrary.org/obo/HP_0001888"},{"id":"A12","pred":"hp_id","subj":"T12","obj":"http://purl.obolibrary.org/obo/HP_0003077"},{"subj":"T11","pred":"source","obj":"LitCovid-PD-HP"},{"subj":"T12","pred":"source","obj":"LitCovid-PD-HP"}]},{"project":"LitCovid-sentences","denotations":[{"id":"T226","span":{"begin":0,"end":192},"obj":"Sentence"},{"id":"T227","span":{"begin":193,"end":239},"obj":"Sentence"},{"id":"T228","span":{"begin":240,"end":482},"obj":"Sentence"},{"id":"T229","span":{"begin":483,"end":586},"obj":"Sentence"},{"id":"T230","span":{"begin":587,"end":692},"obj":"Sentence"},{"id":"T231","span":{"begin":693,"end":807},"obj":"Sentence"},{"id":"T232","span":{"begin":808,"end":1089},"obj":"Sentence"},{"id":"T233","span":{"begin":1090,"end":1193},"obj":"Sentence"},{"id":"T234","span":{"begin":1194,"end":1409},"obj":"Sentence"},{"id":"T235","span":{"begin":1410,"end":1674},"obj":"Sentence"},{"id":"T236","span":{"begin":1675,"end":1837},"obj":"Sentence"},{"id":"T237","span":{"begin":1838,"end":1945},"obj":"Sentence"},{"id":"T238","span":{"begin":1946,"end":2081},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T226","pred":"source","obj":"LitCovid-sentences"},{"subj":"T227","pred":"source","obj":"LitCovid-sentences"},{"subj":"T228","pred":"source","obj":"LitCovid-sentences"},{"subj":"T229","pred":"source","obj":"LitCovid-sentences"},{"subj":"T230","pred":"source","obj":"LitCovid-sentences"},{"subj":"T231","pred":"source","obj":"LitCovid-sentences"},{"subj":"T232","pred":"source","obj":"LitCovid-sentences"},{"subj":"T233","pred":"source","obj":"LitCovid-sentences"},{"subj":"T234","pred":"source","obj":"LitCovid-sentences"},{"subj":"T235","pred":"source","obj":"LitCovid-sentences"},{"subj":"T236","pred":"source","obj":"LitCovid-sentences"},{"subj":"T237","pred":"source","obj":"LitCovid-sentences"},{"subj":"T238","pred":"source","obj":"LitCovid-sentences"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCovid-PD-FMA-UBERON","color":"#c893ec","default":true},{"id":"LitCovid-PubTator","color":"#93ecae"},{"id":"LitCovid-PD-MONDO","color":"#ec9493"},{"id":"LitCovid-PD-CLO","color":"#93acec"},{"id":"LitCovid-PD-CHEBI","color":"#c6ec93"},{"id":"LitCovid-PD-GO-BP","color":"#ec93e0"},{"id":"LitCovid-PD-HP","color":"#93ecde"},{"id":"LitCovid-sentences","color":"#ecc493"}]}]}}