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PMC:7402624 / 26373-34701 JSONTXT

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LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T210 63-75 Body_part denotes plasmablasts http://purl.org/sig/ont/fma/fma84371
T211 106-110 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T212 121-125 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T213 196-200 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T214 296-299 Body_part denotes IgD http://purl.org/sig/ont/fma/fma62876
T215 331-334 Body_part denotes IgD http://purl.org/sig/ont/fma/fma62876
T216 351-356 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T217 427-430 Body_part denotes IgD http://purl.org/sig/ont/fma/fma62876
T218 434-439 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T219 455-457 Body_part denotes PB http://purl.org/sig/ont/fma/fma84371
T220 522-524 Body_part denotes PB http://purl.org/sig/ont/fma/fma84371
T221 559-564 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T222 660-662 Body_part denotes PB http://purl.org/sig/ont/fma/fma84371
T223 752-754 Body_part denotes PB http://purl.org/sig/ont/fma/fma84371
T224 846-850 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T225 1064-1066 Body_part denotes PB http://purl.org/sig/ont/fma/fma84371
T226 1193-1197 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T227 1274-1279 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T228 1342-1347 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T229 1376-1380 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T230 1554-1556 Body_part denotes PB http://purl.org/sig/ont/fma/fma84371
T231 1620-1624 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T232 1754-1758 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T233 1786-1797 Body_part denotes plasmablast http://purl.org/sig/ont/fma/fma84371
T234 1822-1826 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T235 1883-1885 Body_part denotes PB http://purl.org/sig/ont/fma/fma84371
T236 1888-1892 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T237 1961-1963 Body_part denotes PB http://purl.org/sig/ont/fma/fma84371
T238 2066-2071 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T239 2158-2162 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T240 2206-2211 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T241 2255-2257 Body_part denotes PB http://purl.org/sig/ont/fma/fma84371
T242 2311-2313 Body_part denotes PB http://purl.org/sig/ont/fma/fma84371
T243 2333-2336 Body_part denotes IgG http://purl.org/sig/ont/fma/fma62872
T244 2415-2418 Body_part denotes IgM http://purl.org/sig/ont/fma/fma62873
T245 2427-2430 Body_part denotes IgG http://purl.org/sig/ont/fma/fma62872
T246 2471-2476 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T247 2509-2513 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T248 2608-2615 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T249 2741-2745 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T250 2873-2878 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T251 2957-2970 Body_part denotes cell clusters http://purl.org/sig/ont/fma/fma62807
T252 2957-2961 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T253 3070-3075 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T254 3505-3507 Body_part denotes PB http://purl.org/sig/ont/fma/fma84371
T255 3552-3557 Body_part denotes blood http://purl.org/sig/ont/fma/fma9670
T256 3625-3627 Body_part denotes PB http://purl.org/sig/ont/fma/fma84371
T257 3839-3841 Body_part denotes PB http://purl.org/sig/ont/fma/fma84371
T258 3910-3912 Body_part denotes PB http://purl.org/sig/ont/fma/fma84371
T259 4051-4053 Body_part denotes PB http://purl.org/sig/ont/fma/fma84371
T260 4073-4076 Body_part denotes HLA http://purl.org/sig/ont/fma/fma84795
T261 4096-4101 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T262 4149-4153 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T263 4234-4238 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T264 4347-4354 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T265 4363-4366 Body_part denotes IgG http://purl.org/sig/ont/fma/fma62872
T266 4375-4378 Body_part denotes IgM http://purl.org/sig/ont/fma/fma62873
T267 4386-4394 Body_part denotes antibody http://purl.org/sig/ont/fma/fma62871
T268 4425-4427 Body_part denotes PB http://purl.org/sig/ont/fma/fma84371
T269 4487-4495 Body_part denotes antibody http://purl.org/sig/ont/fma/fma62871
T270 4600-4602 Body_part denotes PB http://purl.org/sig/ont/fma/fma84371
T271 4620-4628 Body_part denotes antibody http://purl.org/sig/ont/fma/fma62871
T272 4671-4673 Body_part denotes PB http://purl.org/sig/ont/fma/fma84371
T273 4751-4758 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T274 4852-4855 Body_part denotes IgG http://purl.org/sig/ont/fma/fma62872
T275 4860-4863 Body_part denotes IgM http://purl.org/sig/ont/fma/fma62873
T276 5022-5027 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T277 5125-5127 Body_part denotes PB http://purl.org/sig/ont/fma/fma84371
T278 5214-5216 Body_part denotes PB http://purl.org/sig/ont/fma/fma84371
T279 5294-5299 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T280 5382-5386 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T281 5511-5515 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T282 5561-5564 Body_part denotes IgD http://purl.org/sig/ont/fma/fma62876
T283 5579-5584 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T284 5632-5634 Body_part denotes PB http://purl.org/sig/ont/fma/fma84371
T285 5797-5799 Body_part denotes PB http://purl.org/sig/ont/fma/fma84371
T286 5865-5881 Body_part denotes germinal centers http://purl.org/sig/ont/fma/fma55224
T287 6002-6006 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T288 6138-6141 Body_part denotes map http://purl.org/sig/ont/fma/fma67847
T289 6389-6393 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T290 6622-6638 Body_part denotes cell compartment http://purl.org/sig/ont/fma/fma223408
T291 6622-6626 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T292 6761-6764 Body_part denotes map http://purl.org/sig/ont/fma/fma67847
T293 6830-6833 Body_part denotes map http://purl.org/sig/ont/fma/fma67847
T294 6918-6923 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T295 6925-6928 Body_part denotes IgD http://purl.org/sig/ont/fma/fma62876
T296 6958-6961 Body_part denotes IgD http://purl.org/sig/ont/fma/fma62876
T297 7164-7169 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T298 7364-7369 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T299 7432-7434 Body_part denotes PB http://purl.org/sig/ont/fma/fma84371
T300 7553-7558 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T301 7628-7630 Body_part denotes PB http://purl.org/sig/ont/fma/fma84371
T302 7718-7730 Body_part denotes cell Cluster http://purl.org/sig/ont/fma/fma62807
T303 7718-7722 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T304 7783-7787 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T305 7888-7890 Body_part denotes PB http://purl.org/sig/ont/fma/fma84371
T306 7914-7918 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T307 7953-7957 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T308 8034-8050 Body_part denotes cell compartment http://purl.org/sig/ont/fma/fma223408
T309 8034-8038 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T310 8144-8148 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T311 8233-8237 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T312 8314-8318 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T13 2957-2970 Body_part denotes cell clusters http://purl.obolibrary.org/obo/UBERON_0034922
T14 3552-3557 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T15 5865-5881 Body_part denotes germinal centers http://purl.obolibrary.org/obo/UBERON_0010754
T16 7718-7730 Body_part denotes cell Cluster http://purl.obolibrary.org/obo/UBERON_0034922

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
962 0-8 Disease denotes COVID-19 MESH:C000657245
963 9-18 Disease denotes infection MESH:D007239
1000 300-304 Gene denotes CD27 Gene:939
1001 335-339 Gene denotes CD27 Gene:939
1002 422-426 Gene denotes CD27 Gene:939
1003 444-448 Gene denotes CD27 Gene:939
1004 449-453 Gene denotes CD38 Gene:952
1005 1144-1149 Gene denotes CXCR5 Gene:643
1006 1246-1251 Gene denotes CXCR5 Gene:643
1007 1336-1339 Gene denotes CD4 Gene:920
1008 1545-1549 Gene denotes IL-6 Gene:3569
1009 238-246 Species denotes patients Tax:9606
1010 602-607 Species denotes Ebola Tax:1570291
1011 703-711 Species denotes patients Tax:9606
1012 732-740 Species denotes patients Tax:9606
1013 878-886 Species denotes patients Tax:9606
1014 1113-1121 Species denotes patients Tax:9606
1015 1218-1226 Species denotes patients Tax:9606
1016 522-524 Chemical denotes PB
1017 660-662 Chemical denotes PB
1018 752-754 Chemical denotes PB
1019 1056-1060 Chemical denotes KI67
1020 1064-1066 Chemical denotes PB
1021 1466-1474 Chemical denotes steroids MESH:D013256
1022 162-170 Disease denotes COVID-19 MESH:C000657245
1023 229-237 Disease denotes COVID-19 MESH:C000657245
1024 257-259 Disease denotes HD MESH:D006816
1025 611-634 Disease denotes Dengue virus infections MESH:D003715
1026 778-780 Disease denotes HD MESH:D006816
1027 869-877 Disease denotes COVID-19 MESH:C000657245
1028 998-1007 Disease denotes infection MESH:D007239
1029 1015-1026 Disease denotes lymphopenia MESH:D008231
1030 1104-1112 Disease denotes COVID-19 MESH:C000657245
1031 1134-1136 Disease denotes HD MESH:D006816
1032 1209-1217 Disease denotes COVID-19 MESH:C000657245
1033 1414-1426 Disease denotes co-infection MESH:D060085
1034 1647-1655 Disease denotes COVID-19 MESH:C000657245
1035 1695-1707 Disease denotes inflammation MESH:D007249
1038 1744-1751 Species denotes patient Tax:9606
1039 1735-1743 Disease denotes COVID-19 MESH:C000657245
1054 2113-2118 Gene denotes CXCR5 Gene:643
1055 2142-2147 Gene denotes CXCR5 Gene:643
1056 2176-2181 Gene denotes CXCR5 Gene:643
1057 2200-2203 Gene denotes CD4 Gene:920
1058 2665-2670 Gene denotes Mover Gene:127262
1059 3109-3116 Species denotes cluster Tax:100569
1060 2323-2332 Species denotes SARS-CoV2 Tax:2697049
1061 2401-2410 Species denotes SARS-CoV2 Tax:2697049
1062 2216-2220 Chemical denotes cTfh
1063 2255-2257 Chemical denotes PB
1064 2272-2276 Chemical denotes cTfh
1065 1995-1997 Disease denotes HD MESH:D006816
1066 3192-3194 Disease denotes HD MESH:D006816
1067 3235-3243 Disease denotes COVID-19 MESH:C000657245
1100 3990-4001 Gene denotes S5, B and C Gene:6193
1101 4068-4072 Gene denotes CD38 Gene:952
1102 4090-4093 Gene denotes CD4 Gene:920
1103 4136-4141 Gene denotes CXCR5 Gene:643
1104 4143-4146 Gene denotes CD4 Gene:920
1105 4228-4231 Gene denotes CD8 Gene:925
1106 3758-3769 Gene denotes S5, B and C Gene:6193
1107 3790-3798 Species denotes patients Tax:9606
1108 3889-3897 Species denotes patients Tax:9606
1109 4289-4297 Species denotes patients Tax:9606
1110 4331-4340 Species denotes SARS-CoV2 Tax:2697049
1111 4567-4575 Species denotes patients Tax:9606
1112 4993-5002 Species denotes SARS-CoV2 Tax:2697049
1113 5242-5251 Species denotes SARS-CoV2 Tax:2697049
1114 4711-4720 Species denotes SARS-CoV2 Tax:2697049
1115 4842-4851 Species denotes SARS-CoV2 Tax:2697049
1116 3505-3507 Chemical denotes PB
1117 3577-3581 Chemical denotes cTfh
1118 3625-3627 Chemical denotes PB
1119 3654-3658 Chemical denotes cTfh
1120 3672-3676 Chemical denotes cTfh
1121 3735-3739 Chemical denotes cTfh
1122 3820-3824 Chemical denotes cTfh
1123 3839-3841 Chemical denotes PB
1124 3910-3912 Chemical denotes PB
1125 3967-3971 Chemical denotes cTfh
1126 4917-4921 Chemical denotes cTfh
1127 4973-4977 Chemical denotes cTfh
1128 5214-5216 Chemical denotes PB
1129 3472-3488 Disease denotes viral infections MESH:D001102
1130 4280-4288 Disease denotes COVID-19 MESH:C000657245
1131 4766-4778 Disease denotes inflammation MESH:D007249
1189 5551-5556 Gene denotes CXCR5 Gene:643
1190 5700-5704 Gene denotes CD27 Gene:939
1191 5706-5710 Gene denotes CD38 Gene:952
1192 5712-5717 Gene denotes CD138 Gene:6382
1193 5766-5770 Gene denotes CD95 Gene:355
1194 5780-5784 Gene denotes CD27 Gene:939
1195 5785-5789 Gene denotes CD38 Gene:952
1196 5790-5795 Gene denotes CD138 Gene:6382
1197 6929-6933 Gene denotes CD27 Gene:939
1198 6952-6957 Gene denotes CXCR5 Gene:643
1199 7348-7353 Gene denotes T-bet Gene:30009
1200 7410-7414 Gene denotes CD27 Gene:939
1201 7415-7419 Gene denotes CD38 Gene:952
1202 7420-7425 Gene denotes CD138 Gene:6382
1203 7702-7707 Gene denotes T-bet Gene:30009
1204 7944-7949 Gene denotes T-bet Gene:30009
1205 7978-7983 Gene denotes CXCR5 Gene:643
1206 5326-5334 Species denotes patients Tax:9606
1207 5501-5508 Species denotes patient Tax:9606
1208 5945-5953 Species denotes patients Tax:9606
1209 6275-6283 Species denotes patients Tax:9606
1210 6434-6442 Species denotes patients Tax:9606
1211 6707-6715 Species denotes patients Tax:9606
1212 7066-7074 Species denotes patients Tax:9606
1213 7294-7302 Species denotes patients Tax:9606
1214 7475-7483 Species denotes patients Tax:9606
1215 7573-7581 Species denotes patients Tax:9606
1216 7841-7849 Species denotes patients Tax:9606
1217 8169-8177 Species denotes patients Tax:9606
1218 8269-8277 Species denotes patients Tax:9606
1219 6936-6943 Species denotes Cluster Tax:100569
1220 6985-6992 Species denotes Cluster Tax:100569
1221 7386-7393 Species denotes Cluster Tax:100569
1222 7639-7646 Species denotes Cluster Tax:100569
1223 7723-7730 Species denotes Cluster Tax:100569
1224 5632-5634 Chemical denotes PB
1225 5305-5307 Disease denotes HD MESH:D006816
1226 5317-5325 Disease denotes COVID-19 MESH:C000657245
1227 5402-5410 Disease denotes COVID-19 MESH:C000657245
1228 5448-5450 Disease denotes HD MESH:D006816
1229 5492-5500 Disease denotes COVID-19 MESH:C000657245
1230 5590-5592 Disease denotes HD MESH:D006816
1231 5936-5944 Disease denotes COVID-19 MESH:C000657245
1232 5958-5960 Disease denotes HD MESH:D006816
1233 6266-6274 Disease denotes COVID-19 MESH:C000657245
1234 6425-6433 Disease denotes COVID-19 MESH:C000657245
1235 6485-6487 Disease denotes HD MESH:D006816
1236 6601-6610 Disease denotes infection MESH:D007239
1237 6687-6689 Disease denotes HD MESH:D006816
1238 6698-6706 Disease denotes COVID-19 MESH:C000657245
1239 6883-6885 Disease denotes HD MESH:D006816
1240 7057-7065 Disease denotes COVID-19 MESH:C000657245
1241 7285-7293 Disease denotes COVID-19 MESH:C000657245
1242 7466-7474 Disease denotes COVID-19 MESH:C000657245
1243 7564-7572 Disease denotes COVID-19 MESH:C000657245
1244 7832-7840 Disease denotes COVID-19 MESH:C000657245
1245 8160-8168 Disease denotes COVID-19 MESH:C000657245

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T191 0-8 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T192 9-18 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T193 162-170 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T194 229-237 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T195 251-253 Disease denotes RD http://purl.obolibrary.org/obo/MONDO_0009973
T196 257-259 Disease denotes HD http://purl.obolibrary.org/obo/MONDO_0007739
T197 455-457 Disease denotes PB http://purl.obolibrary.org/obo/MONDO_0019035
T198 522-524 Disease denotes PB http://purl.obolibrary.org/obo/MONDO_0019035
T199 602-607 Disease denotes Ebola http://purl.obolibrary.org/obo/MONDO_0005737
T200 611-617 Disease denotes Dengue http://purl.obolibrary.org/obo/MONDO_0005502
T201 618-634 Disease denotes virus infections http://purl.obolibrary.org/obo/MONDO_0005108
T202 660-662 Disease denotes PB http://purl.obolibrary.org/obo/MONDO_0019035
T203 752-754 Disease denotes PB http://purl.obolibrary.org/obo/MONDO_0019035
T204 778-780 Disease denotes HD http://purl.obolibrary.org/obo/MONDO_0007739
T205 785-787 Disease denotes RD http://purl.obolibrary.org/obo/MONDO_0009973
T206 869-877 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T207 998-1007 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T208 1015-1026 Disease denotes lymphopenia http://purl.obolibrary.org/obo/MONDO_0003783
T209 1064-1066 Disease denotes PB http://purl.obolibrary.org/obo/MONDO_0019035
T210 1104-1112 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T211 1134-1136 Disease denotes HD http://purl.obolibrary.org/obo/MONDO_0007739
T212 1140-1142 Disease denotes RD http://purl.obolibrary.org/obo/MONDO_0009973
T213 1209-1217 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T214 1417-1426 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T215 1428-1446 Disease denotes immune suppression http://purl.obolibrary.org/obo/MONDO_0007816
T216 1554-1556 Disease denotes PB http://purl.obolibrary.org/obo/MONDO_0019035
T217 1647-1655 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T218 1695-1707 Disease denotes inflammation http://purl.obolibrary.org/obo/MONDO_0021166
T219 1735-1743 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T220 1883-1885 Disease denotes PB http://purl.obolibrary.org/obo/MONDO_0019035
T221 1961-1963 Disease denotes PB http://purl.obolibrary.org/obo/MONDO_0019035
T222 1995-1997 Disease denotes HD http://purl.obolibrary.org/obo/MONDO_0007739
T223 2255-2257 Disease denotes PB http://purl.obolibrary.org/obo/MONDO_0019035
T224 2311-2313 Disease denotes PB http://purl.obolibrary.org/obo/MONDO_0019035
T225 2323-2327 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T226 2401-2405 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T227 3192-3194 Disease denotes HD http://purl.obolibrary.org/obo/MONDO_0007739
T228 3221-3223 Disease denotes RD http://purl.obolibrary.org/obo/MONDO_0009973
T229 3235-3243 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T230 3327-3329 Disease denotes BH http://purl.obolibrary.org/obo/MONDO_0010873
T231 3472-3488 Disease denotes viral infections http://purl.obolibrary.org/obo/MONDO_0005108
T232 3505-3507 Disease denotes PB http://purl.obolibrary.org/obo/MONDO_0019035
T233 3625-3627 Disease denotes PB http://purl.obolibrary.org/obo/MONDO_0019035
T234 3839-3841 Disease denotes PB http://purl.obolibrary.org/obo/MONDO_0019035
T235 3910-3912 Disease denotes PB http://purl.obolibrary.org/obo/MONDO_0019035
T236 4051-4053 Disease denotes PB http://purl.obolibrary.org/obo/MONDO_0019035
T237 4280-4288 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T238 4331-4335 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T239 4425-4427 Disease denotes PB http://purl.obolibrary.org/obo/MONDO_0019035
T240 4600-4602 Disease denotes PB http://purl.obolibrary.org/obo/MONDO_0019035
T241 4671-4673 Disease denotes PB http://purl.obolibrary.org/obo/MONDO_0019035
T242 4711-4715 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T243 4766-4778 Disease denotes inflammation http://purl.obolibrary.org/obo/MONDO_0021166
T244 4842-4846 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T245 4993-4997 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T246 5125-5127 Disease denotes PB http://purl.obolibrary.org/obo/MONDO_0019035
T247 5214-5216 Disease denotes PB http://purl.obolibrary.org/obo/MONDO_0019035
T248 5242-5246 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T249 5305-5307 Disease denotes HD http://purl.obolibrary.org/obo/MONDO_0007739
T250 5309-5311 Disease denotes RD http://purl.obolibrary.org/obo/MONDO_0009973
T251 5317-5325 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T252 5402-5410 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T253 5441-5443 Disease denotes RD http://purl.obolibrary.org/obo/MONDO_0009973
T254 5448-5450 Disease denotes HD http://purl.obolibrary.org/obo/MONDO_0007739
T255 5492-5500 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T256 5590-5592 Disease denotes HD http://purl.obolibrary.org/obo/MONDO_0007739
T257 5597-5599 Disease denotes RD http://purl.obolibrary.org/obo/MONDO_0009973
T258 5632-5634 Disease denotes PB http://purl.obolibrary.org/obo/MONDO_0019035
T259 5797-5799 Disease denotes PB http://purl.obolibrary.org/obo/MONDO_0019035
T260 5936-5944 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T261 5958-5960 Disease denotes HD http://purl.obolibrary.org/obo/MONDO_0007739
T262 5965-5967 Disease denotes RD http://purl.obolibrary.org/obo/MONDO_0009973
T263 6266-6274 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T264 6425-6433 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T265 6485-6487 Disease denotes HD http://purl.obolibrary.org/obo/MONDO_0007739
T266 6503-6505 Disease denotes RD http://purl.obolibrary.org/obo/MONDO_0009973
T267 6601-6610 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T268 6687-6689 Disease denotes HD http://purl.obolibrary.org/obo/MONDO_0007739
T269 6691-6693 Disease denotes RD http://purl.obolibrary.org/obo/MONDO_0009973
T270 6698-6706 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T271 6883-6885 Disease denotes HD http://purl.obolibrary.org/obo/MONDO_0007739
T272 6890-6892 Disease denotes RD http://purl.obolibrary.org/obo/MONDO_0009973
T273 7057-7065 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T274 7285-7293 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T275 7432-7434 Disease denotes PB http://purl.obolibrary.org/obo/MONDO_0019035
T276 7466-7474 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T277 7564-7572 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T278 7628-7630 Disease denotes PB http://purl.obolibrary.org/obo/MONDO_0019035
T279 7832-7840 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T280 7888-7890 Disease denotes PB http://purl.obolibrary.org/obo/MONDO_0019035
T281 8160-8168 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T461 104-110 http://purl.obolibrary.org/obo/CL_0000236 denotes B cell
T462 119-125 http://purl.obolibrary.org/obo/CL_0000236 denotes B cell
T463 194-200 http://purl.obolibrary.org/obo/CL_0000236 denotes B cell
T464 251-253 http://purl.obolibrary.org/obo/CLO_0008770 denotes RD
T465 300-304 http://purl.obolibrary.org/obo/PR_000001963 denotes CD27
T466 335-339 http://purl.obolibrary.org/obo/PR_000001963 denotes CD27
T467 349-356 http://purl.obolibrary.org/obo/CL_0000236 denotes B cells
T468 422-426 http://purl.obolibrary.org/obo/PR_000001963 denotes CD27
T469 432-439 http://purl.obolibrary.org/obo/CL_0000236 denotes B cells
T470 444-448 http://purl.obolibrary.org/obo/PR_000001963 denotes CD27
T471 449-453 http://purl.obolibrary.org/obo/PR_000001408 denotes CD38
T472 497-498 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T473 503-504 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T474 557-564 http://purl.obolibrary.org/obo/CL_0000236 denotes B cells
T475 618-623 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T476 785-787 http://purl.obolibrary.org/obo/CLO_0008770 denotes RD
T477 844-850 http://purl.obolibrary.org/obo/CL_0000236 denotes B cell
T478 926-928 http://purl.obolibrary.org/obo/CLO_0001387 denotes 4C
T479 957-958 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T480 1140-1142 http://purl.obolibrary.org/obo/CLO_0008770 denotes RD
T481 1191-1197 http://purl.obolibrary.org/obo/CL_0000236 denotes B cell
T482 1272-1279 http://purl.obolibrary.org/obo/CL_0000236 denotes B cells
T483 1330-1347 http://purl.obolibrary.org/obo/CL_0000895 denotes naïve CD4 T cells
T484 1374-1380 http://purl.obolibrary.org/obo/CL_0000236 denotes B cell
T485 1510-1511 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T486 1618-1624 http://purl.obolibrary.org/obo/CL_0000236 denotes B cell
T487 1752-1758 http://purl.obolibrary.org/obo/CL_0000236 denotes B cell
T488 1820-1826 http://purl.obolibrary.org/obo/CL_0000236 denotes B cell
T489 1841-1842 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T490 1886-1892 http://purl.obolibrary.org/obo/CL_0000236 denotes B cell
T491 1903-1904 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T492 1995-2002 http://purl.obolibrary.org/obo/CLO_0050940 denotes HD. (C)
T493 2064-2071 http://purl.obolibrary.org/obo/CL_0000236 denotes B cells
T494 2156-2162 http://purl.obolibrary.org/obo/CL_0000236 denotes B cell
T495 2194-2211 http://purl.obolibrary.org/obo/CL_0000895 denotes naïve CD4 T cells
T496 2262-2271 http://purl.obolibrary.org/obo/CLO_0001658 denotes activated
T497 2377-2386 http://purl.obolibrary.org/obo/CLO_0001658 denotes activated
T498 2469-2476 http://purl.obolibrary.org/obo/CL_0000236 denotes B cells
T499 2507-2513 http://purl.obolibrary.org/obo/CL_0000236 denotes B cell
T500 2739-2745 http://purl.obolibrary.org/obo/CL_0000236 denotes B cell
T501 2871-2878 http://purl.obolibrary.org/obo/CL_0000236 denotes B cells
T502 2955-2961 http://purl.obolibrary.org/obo/CL_0000236 denotes B cell
T503 3068-3075 http://purl.obolibrary.org/obo/CL_0000236 denotes B cells
T504 3140-3141 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T505 3221-3223 http://purl.obolibrary.org/obo/CLO_0008770 denotes RD
T506 3261-3262 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T507 3317-3321 http://purl.obolibrary.org/obo/UBERON_0000473 denotes test
T508 3552-3557 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T509 3552-3557 http://www.ebi.ac.uk/efo/EFO_0000296 denotes blood
T510 3662-3671 http://purl.obolibrary.org/obo/CLO_0001658 denotes activated
T511 3696-3697 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T512 3725-3734 http://purl.obolibrary.org/obo/CLO_0001658 denotes activated
T513 3758-3760 http://purl.obolibrary.org/obo/CLO_0008933 denotes S5
T514 3762-3763 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T515 3810-3819 http://purl.obolibrary.org/obo/CLO_0001658 denotes activated
T516 3957-3966 http://purl.obolibrary.org/obo/CLO_0001658 denotes activated
T517 3990-3992 http://purl.obolibrary.org/obo/CLO_0008933 denotes S5
T518 3994-3995 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T519 4068-4072 http://purl.obolibrary.org/obo/PR_000001408 denotes CD38
T520 4090-4093 http://purl.obolibrary.org/obo/PR_000001004 denotes CD4
T521 4094-4101 http://purl.obolibrary.org/obo/CL_0000084 denotes T cells
T522 4121-4122 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T523 4143-4146 http://purl.obolibrary.org/obo/PR_000001004 denotes CD4
T524 4147-4153 http://purl.obolibrary.org/obo/CL_0000084 denotes T cell
T525 4180-4181 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T526 4228-4231 http://purl.obolibrary.org/obo/CLO_0053438 denotes CD8
T527 4232-4238 http://purl.obolibrary.org/obo/CL_0000084 denotes T cell
T528 4549-4550 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T529 4643-4644 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T530 4891-4900 http://purl.obolibrary.org/obo/CLO_0001658 denotes activated
T531 4957-4958 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T532 5020-5027 http://purl.obolibrary.org/obo/CL_0000236 denotes B cells
T533 5055-5057 http://purl.obolibrary.org/obo/CLO_0008933 denotes S5
T534 5292-5299 http://purl.obolibrary.org/obo/CL_0000236 denotes B cells
T535 5309-5311 http://purl.obolibrary.org/obo/CLO_0008770 denotes RD
T536 5358-5359 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T537 5380-5386 http://purl.obolibrary.org/obo/CL_0000236 denotes B cell
T538 5441-5443 http://purl.obolibrary.org/obo/CLO_0008770 denotes RD
T539 5509-5515 http://purl.obolibrary.org/obo/CL_0000236 denotes B cell
T540 5577-5584 http://purl.obolibrary.org/obo/CL_0000236 denotes B cells
T541 5597-5599 http://purl.obolibrary.org/obo/CLO_0008770 denotes RD
T542 5700-5704 http://purl.obolibrary.org/obo/PR_000001963 denotes CD27
T543 5706-5710 http://purl.obolibrary.org/obo/PR_000001408 denotes CD38
T544 5780-5784 http://purl.obolibrary.org/obo/PR_000001963 denotes CD27
T545 5785-5789 http://purl.obolibrary.org/obo/PR_000001408 denotes CD38
T546 5965-5967 http://purl.obolibrary.org/obo/CLO_0008770 denotes RD
T547 6000-6006 http://purl.obolibrary.org/obo/CL_0000236 denotes B cell
T548 6054-6056 http://purl.obolibrary.org/obo/CLO_0053799 denotes 45
T549 6387-6393 http://purl.obolibrary.org/obo/CL_0000236 denotes B cell
T550 6503-6505 http://purl.obolibrary.org/obo/CLO_0008770 denotes RD
T551 6620-6626 http://purl.obolibrary.org/obo/CL_0000236 denotes B cell
T552 6691-6693 http://purl.obolibrary.org/obo/CLO_0008770 denotes RD
T553 6890-6892 http://purl.obolibrary.org/obo/CLO_0008770 denotes RD
T554 6916-6923 http://purl.obolibrary.org/obo/CL_0000236 denotes B cells
T555 6929-6933 http://purl.obolibrary.org/obo/PR_000001963 denotes CD27
T556 6962-6966 http://purl.obolibrary.org/obo/PR_000001963 denotes CD27
T557 7162-7169 http://purl.obolibrary.org/obo/CL_0000236 denotes B cells
T558 7362-7369 http://purl.obolibrary.org/obo/CL_0000236 denotes B cells
T559 7410-7414 http://purl.obolibrary.org/obo/PR_000001963 denotes CD27
T560 7415-7419 http://purl.obolibrary.org/obo/PR_000001408 denotes CD38
T561 7551-7558 http://purl.obolibrary.org/obo/CL_0000236 denotes B cells
T562 7716-7722 http://purl.obolibrary.org/obo/CL_0000236 denotes B cell
T563 7781-7787 http://purl.obolibrary.org/obo/CL_0000236 denotes B cell
T564 7912-7918 http://purl.obolibrary.org/obo/CL_0000236 denotes B cell
T565 7942-7943 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T566 7951-7957 http://purl.obolibrary.org/obo/CL_0000236 denotes B cell
T567 8032-8038 http://purl.obolibrary.org/obo/CL_0000236 denotes B cell
T568 8142-8148 http://purl.obolibrary.org/obo/CL_0000236 denotes B cell
T569 8221-8230 http://purl.obolibrary.org/obo/CLO_0001658 denotes activated
T570 8231-8237 http://purl.obolibrary.org/obo/CL_0000236 denotes B cell
T571 8252-8253 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T572 8305-8311 http://purl.obolibrary.org/obo/CLO_0001658 denotes active
T573 8312-8318 http://purl.obolibrary.org/obo/CL_0000236 denotes B cell

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T164 251-253 Chemical denotes RD http://purl.obolibrary.org/obo/CHEBI_73812
T165 257-259 Chemical denotes HD http://purl.obolibrary.org/obo/CHEBI_73925
T166 455-457 Chemical denotes PB http://purl.obolibrary.org/obo/CHEBI_53319|http://purl.obolibrary.org/obo/CHEBI_60686
T168 522-524 Chemical denotes PB http://purl.obolibrary.org/obo/CHEBI_53319|http://purl.obolibrary.org/obo/CHEBI_60686
T170 660-662 Chemical denotes PB http://purl.obolibrary.org/obo/CHEBI_53319|http://purl.obolibrary.org/obo/CHEBI_60686
T172 752-754 Chemical denotes PB http://purl.obolibrary.org/obo/CHEBI_53319|http://purl.obolibrary.org/obo/CHEBI_60686
T174 778-780 Chemical denotes HD http://purl.obolibrary.org/obo/CHEBI_73925
T175 785-787 Chemical denotes RD http://purl.obolibrary.org/obo/CHEBI_73812
T176 914-919 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T177 971-978 Chemical denotes antigen http://purl.obolibrary.org/obo/CHEBI_59132
T178 1064-1066 Chemical denotes PB http://purl.obolibrary.org/obo/CHEBI_53319|http://purl.obolibrary.org/obo/CHEBI_60686
T180 1134-1136 Chemical denotes HD http://purl.obolibrary.org/obo/CHEBI_73925
T181 1140-1142 Chemical denotes RD http://purl.obolibrary.org/obo/CHEBI_73812
T182 1466-1474 Chemical denotes steroids http://purl.obolibrary.org/obo/CHEBI_35341
T183 1545-1547 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T185 1554-1556 Chemical denotes PB http://purl.obolibrary.org/obo/CHEBI_53319|http://purl.obolibrary.org/obo/CHEBI_60686
T187 1883-1885 Chemical denotes PB http://purl.obolibrary.org/obo/CHEBI_53319|http://purl.obolibrary.org/obo/CHEBI_60686
T189 1961-1963 Chemical denotes PB http://purl.obolibrary.org/obo/CHEBI_53319|http://purl.obolibrary.org/obo/CHEBI_60686
T191 1995-1997 Chemical denotes HD http://purl.obolibrary.org/obo/CHEBI_73925
T192 2255-2257 Chemical denotes PB http://purl.obolibrary.org/obo/CHEBI_53319|http://purl.obolibrary.org/obo/CHEBI_60686
T194 2311-2313 Chemical denotes PB http://purl.obolibrary.org/obo/CHEBI_53319|http://purl.obolibrary.org/obo/CHEBI_60686
T196 2608-2615 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T197 2833-2838 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T198 3185-3190 Chemical denotes donor http://purl.obolibrary.org/obo/CHEBI_17891
T199 3192-3194 Chemical denotes HD http://purl.obolibrary.org/obo/CHEBI_73925
T200 3214-3219 Chemical denotes donor http://purl.obolibrary.org/obo/CHEBI_17891
T201 3221-3223 Chemical denotes RD http://purl.obolibrary.org/obo/CHEBI_73812
T202 3505-3507 Chemical denotes PB http://purl.obolibrary.org/obo/CHEBI_53319|http://purl.obolibrary.org/obo/CHEBI_60686
T204 3625-3627 Chemical denotes PB http://purl.obolibrary.org/obo/CHEBI_53319|http://purl.obolibrary.org/obo/CHEBI_60686
T206 3758-3760 Chemical denotes S5 http://purl.obolibrary.org/obo/CHEBI_29386
T207 3839-3841 Chemical denotes PB http://purl.obolibrary.org/obo/CHEBI_53319|http://purl.obolibrary.org/obo/CHEBI_60686
T209 3910-3912 Chemical denotes PB http://purl.obolibrary.org/obo/CHEBI_53319|http://purl.obolibrary.org/obo/CHEBI_60686
T211 3990-3992 Chemical denotes S5 http://purl.obolibrary.org/obo/CHEBI_29386
T212 4051-4053 Chemical denotes PB http://purl.obolibrary.org/obo/CHEBI_53319|http://purl.obolibrary.org/obo/CHEBI_60686
T214 4077-4079 Chemical denotes DR http://purl.obolibrary.org/obo/CHEBI_73445
T215 4347-4354 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T216 4425-4427 Chemical denotes PB http://purl.obolibrary.org/obo/CHEBI_53319|http://purl.obolibrary.org/obo/CHEBI_60686
T218 4600-4602 Chemical denotes PB http://purl.obolibrary.org/obo/CHEBI_53319|http://purl.obolibrary.org/obo/CHEBI_60686
T220 4671-4673 Chemical denotes PB http://purl.obolibrary.org/obo/CHEBI_53319|http://purl.obolibrary.org/obo/CHEBI_60686
T222 4721-4729 Chemical denotes antigens http://purl.obolibrary.org/obo/CHEBI_59132
T223 4751-4758 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T224 5055-5057 Chemical denotes S5 http://purl.obolibrary.org/obo/CHEBI_29386
T225 5125-5127 Chemical denotes PB http://purl.obolibrary.org/obo/CHEBI_53319|http://purl.obolibrary.org/obo/CHEBI_60686
T227 5214-5216 Chemical denotes PB http://purl.obolibrary.org/obo/CHEBI_53319|http://purl.obolibrary.org/obo/CHEBI_60686
T229 5305-5307 Chemical denotes HD http://purl.obolibrary.org/obo/CHEBI_73925
T230 5309-5311 Chemical denotes RD http://purl.obolibrary.org/obo/CHEBI_73812
T231 5441-5443 Chemical denotes RD http://purl.obolibrary.org/obo/CHEBI_73812
T232 5448-5450 Chemical denotes HD http://purl.obolibrary.org/obo/CHEBI_73925
T233 5590-5592 Chemical denotes HD http://purl.obolibrary.org/obo/CHEBI_73925
T234 5597-5599 Chemical denotes RD http://purl.obolibrary.org/obo/CHEBI_73812
T235 5632-5634 Chemical denotes PB http://purl.obolibrary.org/obo/CHEBI_53319|http://purl.obolibrary.org/obo/CHEBI_60686
T237 5797-5799 Chemical denotes PB http://purl.obolibrary.org/obo/CHEBI_53319|http://purl.obolibrary.org/obo/CHEBI_60686
T239 5958-5960 Chemical denotes HD http://purl.obolibrary.org/obo/CHEBI_73925
T240 5965-5967 Chemical denotes RD http://purl.obolibrary.org/obo/CHEBI_73812
T241 6485-6487 Chemical denotes HD http://purl.obolibrary.org/obo/CHEBI_73925
T242 6503-6505 Chemical denotes RD http://purl.obolibrary.org/obo/CHEBI_73812
T243 6687-6689 Chemical denotes HD http://purl.obolibrary.org/obo/CHEBI_73925
T244 6691-6693 Chemical denotes RD http://purl.obolibrary.org/obo/CHEBI_73812
T245 6804-6809 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T246 6883-6885 Chemical denotes HD http://purl.obolibrary.org/obo/CHEBI_73925
T247 6890-6892 Chemical denotes RD http://purl.obolibrary.org/obo/CHEBI_73812
T248 7432-7434 Chemical denotes PB http://purl.obolibrary.org/obo/CHEBI_53319|http://purl.obolibrary.org/obo/CHEBI_60686
T250 7628-7630 Chemical denotes PB http://purl.obolibrary.org/obo/CHEBI_53319|http://purl.obolibrary.org/obo/CHEBI_60686
T252 7888-7890 Chemical denotes PB http://purl.obolibrary.org/obo/CHEBI_53319|http://purl.obolibrary.org/obo/CHEBI_60686
T254 8070-8079 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T255 8260-8265 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T63 97-103 http://purl.obolibrary.org/obo/GO_0007613 denotes memory
T64 342-348 http://purl.obolibrary.org/obo/GO_0007613 denotes memory
T65 1695-1707 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T66 3472-3488 http://purl.obolibrary.org/obo/GO_0016032 denotes viral infections
T67 4766-4778 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T68 6977-6983 http://purl.obolibrary.org/obo/GO_0007613 denotes memory
T69 7355-7361 http://purl.obolibrary.org/obo/GO_0007613 denotes memory
T70 7709-7715 http://purl.obolibrary.org/obo/GO_0007613 denotes memory
T71 7905-7911 http://purl.obolibrary.org/obo/GO_0007613 denotes memory
T72 8070-8089 http://purl.obolibrary.org/obo/GO_0051607 denotes antiviral responses

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T9 1015-1026 Phenotype denotes lymphopenia http://purl.obolibrary.org/obo/HP_0001888

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T158 0-118 Sentence denotes COVID-19 infection is associated with increased frequencies of plasmablasts and proliferation of memory B cell subsets
T159 119-179 Sentence denotes B cell subpopulations were also altered in COVID-19 disease.
T160 180-394 Sentence denotes Whereas naïve B cell frequencies were similar in COVID-19 patients and RD or HD, the frequencies of class-switched (IgD−CD27+) and not-class-switched (IgD+CD27+) memory B cells were significantly reduced (Fig. 4A).
T161 395-506 Sentence denotes Conversely, frequencies of CD27−IgD− B cells and CD27+CD38+ PB were often robustly increased (Fig. 4, A and B).
T162 507-644 Sentence denotes In some cases, PB represented >30% of circulating B cells, similar to levels observed in acute Ebola or Dengue virus infections (42, 43).
T163 645-798 Sentence denotes However, these PB responses were only observed in ~2/3 of patients, with the remaining patients displaying PB frequencies similar to HD and RD (Fig. 4B).
T164 799-930 Sentence denotes KI67 expression was markedly elevated in all B cell subpopulations in COVID-19 patients compared to either control group (Fig. 4C).
T165 931-1048 Sentence denotes This observation suggests a role for an antigen-driven response to infection and/or lymphopenia-driven proliferation.
T166 1049-1143 Sentence denotes Higher KI67 in PB may reflect recent generation in the COVID-19 patients compared to HD or RD.
T167 1144-1237 Sentence denotes CXCR5 expression was also reduced on all major B cell subsets in COVID-19 patients (Fig. 4D).
T168 1238-1358 Sentence denotes Loss of CXCR5 was not specific to B cells, however, as expression was also decreased on non-naïve CD4 T cells (Fig. 4E).
T169 1359-1581 Sentence denotes Changes in the B cell subsets were not associated with co-infection, immune suppression, or treatment with steroids or other clinical features, though a possible negative association of IL-6 and PB was revealed (fig. S5A).
T170 1582-1708 Sentence denotes These observations suggest that the B cell response phenotype of COVID-19 disease was not simply due to systemic inflammation.
T171 1709-1839 Sentence denotes Fig. 4 Deep profiling of COVID-19 patient B cell populations reveals robust plasmablast populations and other B cell alterations.
T172 1840-3117 Sentence denotes (A) Gating strategy and frequencies of non-PB B cell subsets. (B) Representative flow cytometry plots and frequencies of PB; green line at upper decile of HD. (C) Representative flow cytometry plots and frequencies of KI67+ B cells. (D) (Left) Representative histograms of CXCR5 expression and (right) CXCR5 GMFI of B cell subsets. (E) CXCR5 GMFI of non-naïve CD4 T cells and cTfh. (F) Spearman correlation between PB and activated cTfh. (G) Spearman correlation between PB and anti-SARS-CoV2 IgG. (H and I) Spearman correlation between activated cTfh and anti-SARS-CoV2 (H) IgM and (I) IgG. (J) (Top) Global viSNE projection of B cells for all subjects pooled, with B cell populations of each cohort concatenated and overlaid. (Bottom) viSNE projections of indicated protein expression. (K) Hierarchical clustering of Earth Mover’s Distance (EMD) using Pearson correlation, calculated pairwise for B cell populations for all subjects; row-scaled z-score. (L) Percentage of cohort in each EMD group. (M) Global viSNE projection of B cells for all subjects pooled, with EMD groups 1-3 concatenated and overlaid. (N) B cell clusters identified by FlowSOM clustering. (O) MFI as indicated; column-scaled z-score. (P) Percentage of B cells from each cohort in each FlowSOM cluster.
T173 3118-3458 Sentence denotes Boxes represent IQR. (A to F, P) Dots represent individual healthy donor (HD; green), recovered donor (RD; blue), or COVID-19 (red) subjects. (A to E, P) Significance determined by unpaired Wilcoxon test with BH correction: *p < 0.05, **p < 0.01, ***p < 0.001, and ****p < 0.0001. (GtoI) Black horizontal line represents positive threshold.
T174 3459-3597 Sentence denotes During acute viral infections or vaccination, PB responses are transiently detectable in the blood and correlate with cTfh responses (40).
T175 3598-3771 Sentence denotes Comparing the frequency of PB to the frequency of total cTfh or activated cTfh, however, revealed a weak correlation only with activated cTfh (Fig. 4F and fig. S5, B and C).
T176 3772-4003 Sentence denotes Furthermore, some patients had robust activated cTfh responses but PB frequencies similar to controls, whereas other patients with robust PB responses had relatively low frequencies of activated cTfh (Fig. 4F and fig. S5, B and C).
T177 4004-4262 Sentence denotes However, there was also an association between PB frequency and CD38+HLA-DR+ or KI67+ CD4 T cells that might reflect a role for non-CXCR5+ CD4 T cell help (fig. S5D), but such a relationship did not exist for the equivalent CD8 T cell populations (fig. S5E).
T178 4263-4463 Sentence denotes Although ~70% of COVID-19 patients analyzed made antibodies against SARS-CoV2 spike protein (79/111 IgG; 77/115 IgM (44)), antibody levels did not correlate with PB frequencies (Fig. 4G and fig. S5F).
T179 4464-4587 Sentence denotes The occasional lack of antibody did not appear to be related to immunosuppression in a small number of patients (fig. S5G).
T180 4588-4827 Sentence denotes The lack of PB correlation with antibody suggests that a proportion of these large PB responses were: i) generated against SARS-CoV2 antigens other than the spike protein or ii) inflammation-driven and perhaps non-specific or low affinity.
T181 4828-5068 Sentence denotes Notably, anti-SARS-CoV2 IgG and IgM levels correlated with the activated, but not total, cTfh response, suggesting that at least a proportion of cTfh were providing SARS-CoV2-specific help to B cells (Fig. 4, H and I, and fig. S5, H and I).
T182 5069-5252 Sentence denotes Although defining the precise specificity of the robust PB populations will require future studies, these data suggest that at least some of the PB response is specific for SARS-CoV2.
T183 5253-5487 Sentence denotes Projecting the flow cytometry data for B cells from HD, RD, and COVID-19 patients in tSNE space revealed a distinct picture of B cell populations in COVID-19 compared to controls, whereas RD and HD were similar (Fig. 4J and fig. S5J).
T184 5488-5610 Sentence denotes The COVID-19 patient B cell phenotype was dominated by loss of CXCR5 and IgD compared to B cells from HD and RD (Fig. 4J).
T185 5611-5738 Sentence denotes Moreover, the robust PB response was apparent in the upper right section, highlighted by CD27, CD38, CD138, and KI67 (Fig. 4J).
T186 5739-5882 Sentence denotes The expression of KI67 and CD95 in these CD27+CD38+CD138+ PB (Fig. 4J) could suggest recent generation and/or emigration from germinal centers.
T187 5883-6016 Sentence denotes We next asked whether there were different groups of COVID-19 patients (or HD and RD) with global differences in the B cell response.
T188 6017-6249 Sentence denotes We used Earth Movers Distance (EMD) (45) to calculate similarities between the probability distributions within the tSNE map (Fig. 4J) and clustered so that individuals with the most similar distributions grouped together (Fig. 4K).
T189 6250-6403 Sentence denotes The majority of COVID-19 patients fell into two distinct groups (EMD Groups 1 and 3, Fig. 4L), suggesting two major “immunotypes” of the B cell response.
T190 6404-6639 Sentence denotes The remainder of the COVID-19 patients (~25%) clustered with the majority of the HD and all of the RD controls, supporting the observation that some individuals had limited evidence of response to infection in their B cell compartment.
T191 6640-6852 Sentence denotes To identify the population differences between HD, RD and COVID-19 patients, we performed FlowSOM clustering on the tSNE map, and also overlaid each individual EMD group onto this same tSNE map (Fig. 4, M and N).
T192 6853-7085 Sentence denotes EMD Group 2 containing mostly HD and RD was enriched for naive B cells (IgD+CD27−, Cluster 10) and CXCR5+IgD−CD27+ switched memory (Cluster 2) and, indeed, Clusters 2 and 10 were statistically reduced in COVID-19 patients (Fig. 4P).
T193 7086-7161 Sentence denotes EMD Groups 1 and 3 displayed distinct patterns across the FlowSOM clusters.
T194 7162-7313 Sentence denotes B cells from individuals in EMD Group 1 were enriched for the FlowSOM Clusters 1, 5, and 6, all of which were increased in COVID-19 patients (Fig. 4P).
T195 7314-7537 Sentence denotes FlowSOM Clusters 1 and 6 captured T-bet+ memory B cells whereas FlowSOM Cluster 5 contained the CD27+CD38+CD138+KI67+ PB, all of which were enriched in COVID-19 patients compared to controls (Fig. 4, O and P, and fig. S5K).
T196 7538-7774 Sentence denotes In contrast, B cells from COVID-19 patients in EMD Group 3 also showed enrichment for the PB FlowSOM Cluster 5, though less prominent than for EMD Group 1, but the T-bet+ memory B cell Cluster 1 was substantially reduced in EMD Group 3.
T197 7775-7995 Sentence denotes Thus, B cell responses were evident in many hospitalized COVID-19 patients, most often characterized by elevated PB, decreases in memory B cell subsets, enrichment in a T-bet+ B cell subset, and loss of CXCR5 expression.
T198 7996-8101 Sentence denotes Whether all of these changes in the B cell compartment were due to direct antiviral responses is unclear.
T199 8102-8328 Sentence denotes Although there was heterogeneity in the B cell responses, COVID-19 patients fell into two distinct patterns containing activated B cell responses and a third group of patients with little evidence of an active B cell response.

2_test

Id Subject Object Predicate Lexical cue
32669297-25775592-135105208 636-638 25775592 denotes 42
32669297-22238318-135105209 640-642 22238318 denotes 43
32669297-28620653-135105210 3593-3595 28620653 denotes 40
32669297-27008164-135105211 6054-6056 27008164 denotes 45