PMC:7402624 / 18561-21565
Annnotations
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T130 | 40-44 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
| T131 | 76-81 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T132 | 467-482 | Body_part | denotes | germinal center | http://purl.org/sig/ont/fma/fma55224 |
| T133 | 558-563 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T134 | 1004-1007 | Body_part | denotes | HLA | http://purl.org/sig/ont/fma/fma84795 |
| T135 | 1028-1033 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T136 | 1146-1150 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
| T137 | 1214-1217 | Body_part | denotes | HLA | http://purl.org/sig/ont/fma/fma84795 |
| T138 | 1222-1227 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T139 | 1540-1543 | Body_part | denotes | HLA | http://purl.org/sig/ont/fma/fma84795 |
| T140 | 1566-1571 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T141 | 1627-1632 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T142 | 1694-1699 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T143 | 1715-1718 | Body_part | denotes | HLA | http://purl.org/sig/ont/fma/fma84795 |
| T144 | 1819-1824 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T145 | 1869-1874 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T146 | 1961-1965 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
| T147 | 2075-2080 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T148 | 2202-2207 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T149 | 2226-2231 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T150 | 2312-2317 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T151 | 2336-2341 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T152 | 2376-2379 | Body_part | denotes | HLA | http://purl.org/sig/ont/fma/fma84795 |
| T153 | 2400-2404 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
| T154 | 2520-2524 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
| T155 | 2597-2601 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
| T156 | 2685-2689 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
| T157 | 2740-2744 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
| T158 | 2930-2934 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
| T159 | 2967-2970 | Body_part | denotes | HLA | http://purl.org/sig/ont/fma/fma84795 |
LitCovid-PD-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T9 | 467-482 | Body_part | denotes | germinal center | http://purl.obolibrary.org/obo/UBERON_0010754 |
LitCovid-PubTator
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
|---|---|---|---|---|---|
| 680 | 34-37 | Gene | denotes | CD4 | Gene:920 |
| 681 | 70-73 | Gene | denotes | CD8 | Gene:925 |
| 682 | 291-296 | Gene | denotes | CXCR5 | Gene:643 |
| 683 | 342-346 | Gene | denotes | CD38 | Gene:952 |
| 684 | 347-351 | Gene | denotes | ICOS | Gene:29851 |
| 685 | 552-555 | Gene | denotes | CD4 | Gene:920 |
| 686 | 999-1003 | Gene | denotes | CD38 | Gene:952 |
| 687 | 1022-1025 | Gene | denotes | CD4 | Gene:920 |
| 688 | 1140-1143 | Gene | denotes | CD4 | Gene:920 |
| 689 | 1209-1213 | Gene | denotes | CD38 | Gene:952 |
| 690 | 1531-1535 | Gene | denotes | CD38 | Gene:952 |
| 691 | 1560-1563 | Gene | denotes | CD4 | Gene:920 |
| 692 | 1621-1624 | Gene | denotes | CD4 | Gene:920 |
| 693 | 1688-1691 | Gene | denotes | CD4 | Gene:920 |
| 694 | 1710-1714 | Gene | denotes | CD38 | Gene:952 |
| 695 | 1813-1816 | Gene | denotes | CD4 | Gene:920 |
| 696 | 1863-1866 | Gene | denotes | CD8 | Gene:925 |
| 697 | 1948-1951 | Gene | denotes | CD4 | Gene:920 |
| 698 | 1955-1958 | Gene | denotes | CD8 | Gene:925 |
| 699 | 2062-2065 | Gene | denotes | CD4 | Gene:920 |
| 700 | 2069-2072 | Gene | denotes | CD8 | Gene:925 |
| 701 | 2196-2199 | Gene | denotes | CD4 | Gene:920 |
| 702 | 2220-2223 | Gene | denotes | CD8 | Gene:925 |
| 703 | 2306-2309 | Gene | denotes | CD4 | Gene:920 |
| 704 | 2330-2333 | Gene | denotes | CD8 | Gene:925 |
| 705 | 2371-2375 | Gene | denotes | CD38 | Gene:952 |
| 706 | 2394-2397 | Gene | denotes | CD4 | Gene:920 |
| 707 | 2514-2517 | Gene | denotes | CD4 | Gene:920 |
| 708 | 2591-2594 | Gene | denotes | CD4 | Gene:920 |
| 709 | 2679-2682 | Gene | denotes | CD4 | Gene:920 |
| 710 | 2962-2966 | Gene | denotes | CD38 | Gene:952 |
| 711 | 1417-1420 | Gene | denotes | PD1 | Gene:6622 |
| 712 | 287-290 | Gene | denotes | PD1 | Gene:6622 |
| 713 | 226-235 | Species | denotes | SARS-CoV2 | Tax:2697049 |
| 714 | 710-718 | Species | denotes | patients | Tax:9606 |
| 715 | 793-801 | Species | denotes | patients | Tax:9606 |
| 716 | 1061-1069 | Species | denotes | patients | Tax:9606 |
| 717 | 1919-1927 | Species | denotes | patients | Tax:9606 |
| 718 | 2015-2023 | Species | denotes | patients | Tax:9606 |
| 719 | 2150-2158 | Species | denotes | patients | Tax:9606 |
| 720 | 2257-2265 | Species | denotes | patients | Tax:9606 |
| 721 | 2768-2776 | Species | denotes | patients | Tax:9606 |
| 722 | 2885-2893 | Species | denotes | patients | Tax:9606 |
| 723 | 600-603 | Chemical | denotes | EM2 | |
| 724 | 608-612 | Chemical | denotes | EMRA | |
| 725 | 665-669 | Chemical | denotes | cTfh | |
| 726 | 847-851 | Chemical | denotes | cTfh | |
| 727 | 1296-1300 | Chemical | denotes | cTfh | |
| 728 | 1766-1770 | Chemical | denotes | cTfh | |
| 729 | 2629-2636 | Chemical | denotes | steroid | MESH:D013256 |
| 730 | 701-709 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 731 | 731-733 | Disease | denotes | HD | MESH:D006816 |
| 732 | 899-901 | Disease | denotes | HD | MESH:D006816 |
| 733 | 941-949 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 734 | 1052-1060 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 735 | 1493-1495 | Disease | denotes | HD | MESH:D006816 |
| 736 | 2006-2014 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 737 | 2104-2106 | Disease | denotes | HD | MESH:D006816 |
| 738 | 2759-2767 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 739 | 2820-2836 | Disease | denotes | acute infections | MESH:D007239 |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T141 | 226-230 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T142 | 701-709 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T143 | 731-733 | Disease | denotes | HD | http://purl.obolibrary.org/obo/MONDO_0007739 |
| T144 | 884-886 | Disease | denotes | RD | http://purl.obolibrary.org/obo/MONDO_0009973 |
| T145 | 899-901 | Disease | denotes | HD | http://purl.obolibrary.org/obo/MONDO_0007739 |
| T146 | 941-949 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T147 | 1052-1060 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T148 | 1493-1495 | Disease | denotes | HD | http://purl.obolibrary.org/obo/MONDO_0007739 |
| T149 | 1499-1501 | Disease | denotes | RD | http://purl.obolibrary.org/obo/MONDO_0009973 |
| T150 | 2006-2014 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T151 | 2104-2106 | Disease | denotes | HD | http://purl.obolibrary.org/obo/MONDO_0007739 |
| T152 | 2759-2767 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T153 | 2826-2836 | Disease | denotes | infections | http://purl.obolibrary.org/obo/MONDO_0005550 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T311 | 34-37 | http://purl.obolibrary.org/obo/PR_000001004 | denotes | CD4 |
| T312 | 38-44 | http://purl.obolibrary.org/obo/CL_0000084 | denotes | T cell |
| T313 | 70-73 | http://purl.obolibrary.org/obo/CLO_0053438 | denotes | CD8 |
| T314 | 74-81 | http://purl.obolibrary.org/obo/CL_0000084 | denotes | T cells |
| T315 | 237-239 | http://purl.obolibrary.org/obo/CLO_0050509 | denotes | 27 |
| T316 | 280-286 | http://purl.obolibrary.org/obo/PR_000001015 | denotes | CD45RA |
| T317 | 306-308 | http://purl.obolibrary.org/obo/CLO_0001313 | denotes | 36 |
| T318 | 315-324 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activated |
| T319 | 342-346 | http://purl.obolibrary.org/obo/PR_000001408 | denotes | CD38 |
| T320 | 354-363 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activated |
| T321 | 527-528 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T322 | 546-563 | http://purl.obolibrary.org/obo/CL_0000895 | denotes | naïve CD4 T cells |
| T323 | 600-603 | http://purl.obolibrary.org/obo/CLO_0002922 | denotes | EM2 |
| T324 | 641-650 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activated |
| T325 | 779-780 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T326 | 837-846 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activated |
| T327 | 884-886 | http://purl.obolibrary.org/obo/CLO_0008770 | denotes | RD |
| T328 | 999-1003 | http://purl.obolibrary.org/obo/PR_000001408 | denotes | CD38 |
| T329 | 1016-1033 | http://purl.obolibrary.org/obo/CL_0000895 | denotes | naïve CD4 T cells |
| T330 | 1140-1143 | http://purl.obolibrary.org/obo/PR_000001004 | denotes | CD4 |
| T331 | 1144-1150 | http://purl.obolibrary.org/obo/CL_0000084 | denotes | T cell |
| T332 | 1209-1213 | http://purl.obolibrary.org/obo/PR_000001408 | denotes | CD38 |
| T333 | 1222-1227 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T334 | 1279-1282 | http://purl.obolibrary.org/obo/CLO_0002922 | denotes | EM2 |
| T335 | 1284-1287 | http://purl.obolibrary.org/obo/CLO_0002923 | denotes | EM3 |
| T336 | 1311-1312 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | A |
| T337 | 1317-1318 | http://purl.obolibrary.org/obo/CLO_0001021 | denotes | B |
| T338 | 1358-1368 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activation |
| T339 | 1499-1501 | http://purl.obolibrary.org/obo/CLO_0008770 | denotes | RD |
| T340 | 1531-1535 | http://purl.obolibrary.org/obo/PR_000001408 | denotes | CD38 |
| T341 | 1554-1571 | http://purl.obolibrary.org/obo/CL_0000895 | denotes | naïve CD4 T cells |
| T342 | 1615-1632 | http://purl.obolibrary.org/obo/CL_0000895 | denotes | naïve CD4 T cells |
| T343 | 1682-1699 | http://purl.obolibrary.org/obo/CL_0000895 | denotes | naïve CD4 T cells |
| T344 | 1710-1714 | http://purl.obolibrary.org/obo/PR_000001408 | denotes | CD38 |
| T345 | 1756-1765 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activated |
| T346 | 1799-1809 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activation |
| T347 | 1813-1816 | http://purl.obolibrary.org/obo/PR_000001004 | denotes | CD4 |
| T348 | 1817-1824 | http://purl.obolibrary.org/obo/CL_0000084 | denotes | T cells |
| T349 | 1849-1859 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activation |
| T350 | 1863-1866 | http://purl.obolibrary.org/obo/CLO_0053438 | denotes | CD8 |
| T351 | 1867-1874 | http://purl.obolibrary.org/obo/CL_0000084 | denotes | T cells |
| T352 | 1948-1951 | http://purl.obolibrary.org/obo/PR_000001004 | denotes | CD4 |
| T353 | 1955-1958 | http://purl.obolibrary.org/obo/CLO_0053438 | denotes | CD8 |
| T354 | 1959-1965 | http://purl.obolibrary.org/obo/CL_0000084 | denotes | T cell |
| T355 | 2062-2065 | http://purl.obolibrary.org/obo/PR_000001004 | denotes | CD4 |
| T356 | 2069-2072 | http://purl.obolibrary.org/obo/CLO_0053438 | denotes | CD8 |
| T357 | 2073-2080 | http://purl.obolibrary.org/obo/CL_0000084 | denotes | T cells |
| T358 | 2186-2195 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activated |
| T359 | 2196-2199 | http://purl.obolibrary.org/obo/PR_000001004 | denotes | CD4 |
| T360 | 2200-2207 | http://purl.obolibrary.org/obo/CL_0000084 | denotes | T cells |
| T361 | 2220-2223 | http://purl.obolibrary.org/obo/CLO_0053438 | denotes | CD8 |
| T362 | 2224-2231 | http://purl.obolibrary.org/obo/CL_0000084 | denotes | T cells |
| T363 | 2243-2244 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T364 | 2292-2302 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activation |
| T365 | 2306-2309 | http://purl.obolibrary.org/obo/PR_000001004 | denotes | CD4 |
| T366 | 2310-2317 | http://purl.obolibrary.org/obo/CL_0000084 | denotes | T cells |
| T367 | 2330-2333 | http://purl.obolibrary.org/obo/CLO_0053438 | denotes | CD8 |
| T368 | 2334-2341 | http://purl.obolibrary.org/obo/CL_0000084 | denotes | T cells |
| T369 | 2371-2375 | http://purl.obolibrary.org/obo/PR_000001408 | denotes | CD38 |
| T370 | 2388-2404 | http://purl.obolibrary.org/obo/CL_0000895 | denotes | naïve CD4 T cell |
| T371 | 2491-2492 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T372 | 2514-2517 | http://purl.obolibrary.org/obo/PR_000001004 | denotes | CD4 |
| T373 | 2518-2524 | http://purl.obolibrary.org/obo/CL_0000084 | denotes | T cell |
| T374 | 2525-2535 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activation |
| T375 | 2591-2594 | http://purl.obolibrary.org/obo/PR_000001004 | denotes | CD4 |
| T376 | 2595-2601 | http://purl.obolibrary.org/obo/CL_0000084 | denotes | T cell |
| T377 | 2602-2612 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activation |
| T378 | 2679-2682 | http://purl.obolibrary.org/obo/PR_000001004 | denotes | CD4 |
| T379 | 2683-2689 | http://purl.obolibrary.org/obo/CL_0000084 | denotes | T cell |
| T380 | 2738-2744 | http://purl.obolibrary.org/obo/CL_0000084 | denotes | T cell |
| T381 | 2745-2755 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activation |
| T382 | 2793-2796 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
| T383 | 2928-2934 | http://purl.obolibrary.org/obo/CL_0000084 | denotes | T cell |
| T384 | 2962-2966 | http://purl.obolibrary.org/obo/PR_000001408 | denotes | CD38 |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T94 | 100-108 | Chemical | denotes | effector | http://purl.obolibrary.org/obo/CHEBI_35224 |
| T95 | 287-290 | Chemical | denotes | PD1 | http://purl.obolibrary.org/obo/CHEBI_138655 |
| T96 | 425-432 | Chemical | denotes | antigen | http://purl.obolibrary.org/obo/CHEBI_59132 |
| T97 | 731-733 | Chemical | denotes | HD | http://purl.obolibrary.org/obo/CHEBI_73925 |
| T98 | 884-886 | Chemical | denotes | RD | http://purl.obolibrary.org/obo/CHEBI_73812 |
| T99 | 899-901 | Chemical | denotes | HD | http://purl.obolibrary.org/obo/CHEBI_73925 |
| T100 | 968-973 | Chemical | denotes | group | http://purl.obolibrary.org/obo/CHEBI_24433 |
| T101 | 1008-1010 | Chemical | denotes | DR | http://purl.obolibrary.org/obo/CHEBI_73445 |
| T102 | 1218-1220 | Chemical | denotes | DR | http://purl.obolibrary.org/obo/CHEBI_73445 |
| T103 | 1246-1254 | Chemical | denotes | effector | http://purl.obolibrary.org/obo/CHEBI_35224 |
| T104 | 1275-1277 | Chemical | denotes | EM | http://purl.obolibrary.org/obo/CHEBI_73507 |
| T105 | 1307-1309 | Chemical | denotes | S3 | http://purl.obolibrary.org/obo/CHEBI_29388 |
| T106 | 1417-1420 | Chemical | denotes | PD1 | http://purl.obolibrary.org/obo/CHEBI_138655 |
| T107 | 1493-1495 | Chemical | denotes | HD | http://purl.obolibrary.org/obo/CHEBI_73925 |
| T108 | 1499-1501 | Chemical | denotes | RD | http://purl.obolibrary.org/obo/CHEBI_73812 |
| T109 | 1514-1516 | Chemical | denotes | Co | http://purl.obolibrary.org/obo/CHEBI_27638 |
| T110 | 1544-1546 | Chemical | denotes | DR | http://purl.obolibrary.org/obo/CHEBI_73445 |
| T111 | 1719-1721 | Chemical | denotes | DR | http://purl.obolibrary.org/obo/CHEBI_73445 |
| T112 | 2104-2106 | Chemical | denotes | HD | http://purl.obolibrary.org/obo/CHEBI_73925 |
| T113 | 2380-2382 | Chemical | denotes | DR | http://purl.obolibrary.org/obo/CHEBI_73445 |
| T114 | 2629-2636 | Chemical | denotes | steroid | http://purl.obolibrary.org/obo/CHEBI_35341 |
| T115 | 2971-2973 | Chemical | denotes | DR | http://purl.obolibrary.org/obo/CHEBI_73445 |
LitCovid-PD-GO-BP
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T45 | 109-115 | http://purl.obolibrary.org/obo/GO_0007613 | denotes | memory |
| T46 | 135-141 | http://purl.obolibrary.org/obo/GO_0007613 | denotes | memory |
| T47 | 1255-1261 | http://purl.obolibrary.org/obo/GO_0007613 | denotes | memory |
| T48 | 2518-2535 | http://purl.obolibrary.org/obo/GO_0042110 | denotes | T cell activation |
| T49 | 2520-2535 | http://purl.obolibrary.org/obo/GO_0001775 | denotes | cell activation |
| T50 | 2595-2612 | http://purl.obolibrary.org/obo/GO_0042110 | denotes | T cell activation |
| T51 | 2597-2612 | http://purl.obolibrary.org/obo/GO_0001775 | denotes | cell activation |
| T52 | 2738-2755 | http://purl.obolibrary.org/obo/GO_0042110 | denotes | T cell activation |
| T53 | 2740-2755 | http://purl.obolibrary.org/obo/GO_0001775 | denotes | cell activation |
LitCovid-PD-GlycoEpitope
| Id | Subject | Object | Predicate | Lexical cue | glyco_epitope_db_id |
|---|---|---|---|---|---|
| T8 | 600-603 | GlycoEpitope | denotes | EM2 | http://www.glycoepitope.jp/epitopes/AN0703 |
| T9 | 1279-1282 | GlycoEpitope | denotes | EM2 | http://www.glycoepitope.jp/epitopes/AN0703 |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T117 | 0-167 | Sentence | denotes | We next examined six well-defined CD4 T cell subsets as above for the CD8 T cells, including naïve, effector memory (EM1,2,3), central memory (CM), and EMRA (Fig. 3A). |
| T118 | 168-502 | Sentence | denotes | Given the potential role of antibodies in the response to SARS-CoV2 (27, 29), we also analyzed circulating Tfh (CD45RA−PD1+CXCR5+ [cTfh] (36)) and activated circulating Tfh (CD38+ICOS+ [activated cTfh]), the latter of which may be more reflective of recent antigen encounter and emigration from the germinal center (37, 38) (Fig. 3A). |
| T119 | 503-623 | Sentence | denotes | These analyses revealed a relative loss of naïve CD4 T cells compared to controls, but increased EM2 and EMRA (Fig. 3B). |
| T120 | 624-812 | Sentence | denotes | The frequency of activated but not total cTfh was statistically increased in COVID-19 patients compared to HD, though this effect appeared to be driven by a subgroup of patients (Fig. 3B). |
| T121 | 813-974 | Sentence | denotes | It is worth noting that activated cTfh frequencies were also higher in RD compared to HD (Fig. 3B), perhaps reflecting residual COVID-19 responses in that group. |
| T122 | 975-1159 | Sentence | denotes | Frequencies of KI67+ or CD38+HLA-DR+ non-naïve CD4 T cells were increased in COVID-19 patients (Fig. 3, C and E); however, this change was not equivalent across all CD4 T cell subsets. |
| T123 | 1160-1320 | Sentence | denotes | The most substantial increases in both KI67+ and CD38+HLA-DR+ cells were found in the effector memory populations (EM, EM2, EM3) and in cTfh (fig. S3, A and B). |
| T124 | 1321-1403 | Sentence | denotes | Although some subjects had increased activation of EMRA, this was less pronounced. |
| T125 | 1404-1513 | Sentence | denotes | In contrast, PD1 expression was increased in all other non-naïve populations compared to HD or RD (fig. S3C). |
| T126 | 1514-1644 | Sentence | denotes | Co-expression of CD38 and HLA-DR by non-naïve CD4 T cells correlated with the frequency of KI67+ non-naïve CD4 T cells (fig. S3D). |
| T127 | 1645-1782 | Sentence | denotes | Moreover, the frequency of total non-naïve CD4 T cells that were CD38+HLA-DR+ correlated with the frequency of activated cTfh (fig. S3E). |
| T128 | 1783-1893 | Sentence | denotes | In general, the activation of CD4 T cells was correlated with the activation of CD8 T cells (Fig. 3, D and F). |
| T129 | 1894-2125 | Sentence | denotes | However, whereas ~2/3 of patients had KI67+ non-naïve CD4 or CD8 T cell frequencies above controls, ~1/3 of the COVID-19 patients had no increase in frequency of KI67+ CD4 or CD8 T cells above that observed in HD (Fig. 3, D and F). |
| T130 | 2126-2360 | Sentence | denotes | Moreover, although most patients had similar proportions of activated CD4 T cells compared to CD8 T cells, there was a subgroup of patients that had disproportionate activation of CD4 T cells compared to CD8 T cells (Fig. 3, D and F). |
| T131 | 2361-2557 | Sentence | denotes | KI67+ and CD38+HLA-DR+ non-naïve CD4 T cell frequencies correlated with ferritin and with APACHE III score (fig. S3F), suggesting a relationship between CD4 T cell activation and disease severity. |
| T132 | 2558-2706 | Sentence | denotes | Immunosuppression did not impact CD4 T cell activation; however, early steroid administration was weakly associated with CD4 T cell KI67 (fig. S3F). |
| T133 | 2707-3004 | Sentence | denotes | Together, these data highlight T cell activation in COVID-19 patients similar to what has been observed in other acute infections or vaccinations (37, 39, 40), but also identify patients with high, low, or essentially no T cell response based on KI67+ or CD38+HLA-DR+ compared to control subjects. |
2_test
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| 32669297-32267220-135105200 | 237-239 | 32267220 | denotes | 27 |
| 32669297-32413330-135105201 | 241-243 | 32413330 | denotes | 29 |
| 32669297-31117010-135105202 | 306-308 | 31117010 | denotes | 36 |
| 32669297-25172499-135105203 | 488-490 | 25172499 | denotes | 38 |
| 32669297-32320677-135105204 | 2858-2860 | 32320677 | denotes | 39 |
| 32669297-28620653-135105205 | 2862-2864 | 28620653 | denotes | 40 |