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PMC:7402624 / 18450-26371 JSONTXT

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LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T128 59-63 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T129 98-102 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T130 151-155 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T131 187-192 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T132 578-593 Body_part denotes germinal center http://purl.org/sig/ont/fma/fma55224
T133 669-674 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T134 1115-1118 Body_part denotes HLA http://purl.org/sig/ont/fma/fma84795
T135 1139-1144 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T136 1257-1261 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T137 1325-1328 Body_part denotes HLA http://purl.org/sig/ont/fma/fma84795
T138 1333-1338 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T139 1651-1654 Body_part denotes HLA http://purl.org/sig/ont/fma/fma84795
T140 1677-1682 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T141 1738-1743 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T142 1805-1810 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T143 1826-1829 Body_part denotes HLA http://purl.org/sig/ont/fma/fma84795
T144 1930-1935 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T145 1980-1985 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T146 2072-2076 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T147 2186-2191 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T148 2313-2318 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T149 2337-2342 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T150 2423-2428 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T151 2447-2452 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T152 2487-2490 Body_part denotes HLA http://purl.org/sig/ont/fma/fma84795
T153 2511-2515 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T154 2631-2635 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T155 2708-2712 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T156 2796-2800 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T157 2851-2855 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T158 3041-3045 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T159 3078-3081 Body_part denotes HLA http://purl.org/sig/ont/fma/fma84795
T160 3130-3134 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T161 3210-3214 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T162 3297-3301 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T163 3336-3340 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T164 3388-3393 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T165 3493-3498 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T166 3520-3525 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T167 3549-3554 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T168 3618-3621 Body_part denotes HLA http://purl.org/sig/ont/fma/fma84795
T169 3625-3636 Body_part denotes CD38+ cells http://purl.org/sig/ont/fma/fma0326121
T170 3631-3636 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T171 3730-3733 Body_part denotes HLA http://purl.org/sig/ont/fma/fma84795
T172 3737-3748 Body_part denotes CD38+ cells http://purl.org/sig/ont/fma/fma0326121
T173 3743-3748 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T174 3791-3796 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T175 3894-3899 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T176 3941-3946 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T177 4049-4056 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T178 4109-4122 Body_part denotes cell clusters http://purl.org/sig/ont/fma/fma62807
T179 4109-4113 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T180 4266-4271 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T181 4619-4623 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T182 4734-4738 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T183 4923-4926 Body_part denotes HLA http://purl.org/sig/ont/fma/fma84795
T184 4985-4990 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T185 5030-5034 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T186 5247-5250 Body_part denotes HLA http://purl.org/sig/ont/fma/fma84795
T187 5353-5358 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T188 5471-5476 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T189 5658-5663 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T190 5884-5894 Body_part denotes chemokines http://purl.org/sig/ont/fma/fma241981
T191 5895-5904 Body_part denotes cytokines http://purl.org/sig/ont/fma/fma84050
T192 6034-6038 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T193 6098-6104 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T194 6279-6284 Body_part denotes blood http://purl.org/sig/ont/fma/fma9670
T195 6323-6326 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T196 6343-6348 Body_part denotes blood http://purl.org/sig/ont/fma/fma9670
T197 6421-6427 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T198 6631-6641 Body_part denotes chemokines http://purl.org/sig/ont/fma/fma241981
T199 6673-6684 Body_part denotes eosinophils http://purl.org/sig/ont/fma/fma62861
T200 6686-6693 Body_part denotes eotaxin http://purl.org/sig/ont/fma/fma241992
T201 6710-6715 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T202 7057-7064 Body_part denotes eotaxin http://purl.org/sig/ont/fma/fma241992
T203 7210-7216 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T204 7276-7281 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T205 7433-7438 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T206 7609-7614 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T207 7855-7864 Body_part denotes cytokines http://purl.org/sig/ont/fma/fma84050
T208 7869-7879 Body_part denotes chemokines http://purl.org/sig/ont/fma/fma241981
T209 7910-7920 Body_part denotes chemokines http://purl.org/sig/ont/fma/fma241981

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T9 578-593 Body_part denotes germinal center http://purl.obolibrary.org/obo/UBERON_0010754
T10 4109-4122 Body_part denotes cell clusters http://purl.obolibrary.org/obo/UBERON_0034922
T11 6279-6284 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T12 6343-6348 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
616 53-56 Gene denotes CD4 Gene:920
617 92-95 Gene denotes CD4 Gene:920
618 0-9 Species denotes SARS-CoV2 Tax:2697049
619 10-19 Disease denotes infection MESH:D007239
680 145-148 Gene denotes CD4 Gene:920
681 181-184 Gene denotes CD8 Gene:925
682 402-407 Gene denotes CXCR5 Gene:643
683 453-457 Gene denotes CD38 Gene:952
684 458-462 Gene denotes ICOS Gene:29851
685 663-666 Gene denotes CD4 Gene:920
686 1110-1114 Gene denotes CD38 Gene:952
687 1133-1136 Gene denotes CD4 Gene:920
688 1251-1254 Gene denotes CD4 Gene:920
689 1320-1324 Gene denotes CD38 Gene:952
690 1642-1646 Gene denotes CD38 Gene:952
691 1671-1674 Gene denotes CD4 Gene:920
692 1732-1735 Gene denotes CD4 Gene:920
693 1799-1802 Gene denotes CD4 Gene:920
694 1821-1825 Gene denotes CD38 Gene:952
695 1924-1927 Gene denotes CD4 Gene:920
696 1974-1977 Gene denotes CD8 Gene:925
697 2059-2062 Gene denotes CD4 Gene:920
698 2066-2069 Gene denotes CD8 Gene:925
699 2173-2176 Gene denotes CD4 Gene:920
700 2180-2183 Gene denotes CD8 Gene:925
701 2307-2310 Gene denotes CD4 Gene:920
702 2331-2334 Gene denotes CD8 Gene:925
703 2417-2420 Gene denotes CD4 Gene:920
704 2441-2444 Gene denotes CD8 Gene:925
705 2482-2486 Gene denotes CD38 Gene:952
706 2505-2508 Gene denotes CD4 Gene:920
707 2625-2628 Gene denotes CD4 Gene:920
708 2702-2705 Gene denotes CD4 Gene:920
709 2790-2793 Gene denotes CD4 Gene:920
710 3073-3077 Gene denotes CD38 Gene:952
711 1528-1531 Gene denotes PD1 Gene:6622
712 398-401 Gene denotes PD1 Gene:6622
713 337-346 Species denotes SARS-CoV2 Tax:2697049
714 821-829 Species denotes patients Tax:9606
715 904-912 Species denotes patients Tax:9606
716 1172-1180 Species denotes patients Tax:9606
717 2030-2038 Species denotes patients Tax:9606
718 2126-2134 Species denotes patients Tax:9606
719 2261-2269 Species denotes patients Tax:9606
720 2368-2376 Species denotes patients Tax:9606
721 2879-2887 Species denotes patients Tax:9606
722 2996-3004 Species denotes patients Tax:9606
723 711-714 Chemical denotes EM2
724 719-723 Chemical denotes EMRA
725 776-780 Chemical denotes cTfh
726 958-962 Chemical denotes cTfh
727 1407-1411 Chemical denotes cTfh
728 1877-1881 Chemical denotes cTfh
729 2740-2747 Chemical denotes steroid MESH:D013256
730 812-820 Disease denotes COVID-19 MESH:C000657245
731 842-844 Disease denotes HD MESH:D006816
732 1010-1012 Disease denotes HD MESH:D006816
733 1052-1060 Disease denotes COVID-19 MESH:C000657245
734 1163-1171 Disease denotes COVID-19 MESH:C000657245
735 1604-1606 Disease denotes HD MESH:D006816
736 2117-2125 Disease denotes COVID-19 MESH:C000657245
737 2215-2217 Disease denotes HD MESH:D006816
738 2870-2878 Disease denotes COVID-19 MESH:C000657245
739 2931-2947 Disease denotes acute infections MESH:D007239
744 3124-3127 Gene denotes CD4 Gene:920
745 3204-3207 Gene denotes CD4 Gene:920
746 3170-3178 Species denotes patients Tax:9606
747 3161-3169 Disease denotes COVID-19 MESH:C000657245
773 3291-3294 Gene denotes CD4 Gene:920
774 3330-3333 Gene denotes CD4 Gene:920
775 3514-3517 Gene denotes CD4 Gene:920
776 3543-3546 Gene denotes CD8 Gene:925
777 3625-3629 Gene denotes CD38 Gene:952
778 3737-3741 Gene denotes CD38 Gene:952
779 3764-3767 Gene denotes CD4 Gene:920
780 3785-3788 Gene denotes CD8 Gene:925
781 3888-3891 Gene denotes CD4 Gene:920
782 3935-3938 Gene denotes CD4 Gene:920
783 4103-4106 Gene denotes CD4 Gene:920
784 4260-4263 Gene denotes CD4 Gene:920
785 3589-3597 Species denotes patients Tax:9606
786 3831-3839 Species denotes patients Tax:9606
787 3973-3981 Species denotes patients Tax:9606
788 4449-4456 Species denotes patient Tax:9606
789 4305-4312 Species denotes cluster Tax:100569
790 3441-3443 Disease denotes HD MESH:D006816
791 3580-3588 Disease denotes COVID-19 MESH:C000657245
792 3684-3686 Disease denotes HD MESH:D006816
793 3822-3830 Disease denotes COVID-19 MESH:C000657245
794 3952-3954 Disease denotes HD MESH:D006816
795 3964-3972 Disease denotes COVID-19 MESH:C000657245
796 4397-4399 Disease denotes HD MESH:D006816
797 4440-4448 Disease denotes COVID-19 MESH:C000657245
827 4613-4616 Gene denotes CD4 Gene:920
828 4728-4731 Gene denotes CD4 Gene:920
829 4917-4921 Gene denotes CD38 Gene:952
830 4931-4934 Gene denotes PD1 Gene:6622
831 4936-4940 Gene denotes CD39 Gene:953
832 4952-4956 Gene denotes CD95 Gene:355
833 4979-4982 Gene denotes CD8 Gene:925
834 5024-5027 Gene denotes CD4 Gene:920
835 5255-5259 Gene denotes CD38 Gene:952
836 5261-5264 Gene denotes PD1 Gene:6622
837 5275-5279 Gene denotes CD95 Gene:355
838 5318-5322 Gene denotes Tbet Gene:30009
839 5323-5329 Gene denotes CX3CR1 Gene:1524
840 5347-5350 Gene denotes CD4 Gene:920
841 5454-5459 Gene denotes CXCR5 Gene:643
842 5652-5655 Gene denotes CD4 Gene:920
843 5178-5186 Species denotes patients Tax:9606
844 5695-5703 Species denotes patients Tax:9606
845 5292-5299 Species denotes Cluster Tax:100569
846 4755-4763 Disease denotes COVID-19 MESH:C000657245
847 4764-4773 Disease denotes infection MESH:D007239
848 4786-4789 Disease denotes HDs
849 4812-4820 Disease denotes COVID-19 MESH:C000657245
850 4821-4830 Disease denotes infection MESH:D007239
851 5169-5177 Disease denotes COVID-19 MESH:C000657245
852 5199-5201 Disease denotes HD MESH:D006816
853 5496-5504 Disease denotes COVID-19 MESH:C000657245
854 5526-5528 Disease denotes HD MESH:D006816
855 5686-5694 Disease denotes COVID-19 MESH:C000657245
908 5916-5922 Gene denotes IL-1RA Gene:3557
909 5924-5928 Gene denotes IL-6 Gene:3569
910 5930-5934 Gene denotes IL-8 Gene:3576
911 5936-5941 Gene denotes IL-10 Gene:3586
912 5947-5953 Gene denotes CXCL10 Gene:3627
913 6147-6151 Gene denotes CD28 Gene:940
914 6428-6434 Gene denotes CXCL10 Gene:3627
915 6559-6564 Gene denotes CXCL9 Gene:4283
916 6566-6570 Gene denotes CCL2 Gene:6347
917 6576-6582 Gene denotes IL-1RA Gene:3557
918 6686-6693 Gene denotes eotaxin Gene:6356
919 6717-6721 Gene denotes CCL5 Gene:6352
920 6739-6743 Gene denotes IL-6 Gene:3569
921 6879-6883 Gene denotes IL-6 Gene:3569
922 7043-7047 Gene denotes CCL2 Gene:6347
923 7049-7055 Gene denotes CXCL10 Gene:3627
924 7057-7064 Gene denotes eotaxin Gene:6356
925 7070-7076 Gene denotes IL-1RA Gene:3557
926 7126-7132 Gene denotes CXCL10 Gene:3627
927 7137-7141 Gene denotes CCL2 Gene:6347
928 7270-7273 Gene denotes CD8 Gene:925
929 7331-7335 Gene denotes IFNɣ Gene:3458
930 7427-7430 Gene denotes CD8 Gene:925
931 7487-7491 Gene denotes IFNɣ Gene:3458
932 7626-7630 Gene denotes IFNɣ Gene:3458
933 5804-5812 Species denotes patients Tax:9606
934 6194-6202 Species denotes patients Tax:9606
935 6271-6278 Species denotes patient Tax:9606
936 6313-6322 Species denotes SARS-CoV2 Tax:2697049
937 6408-6416 Species denotes patients Tax:9606
938 6778-6786 Species denotes patients Tax:9606
939 7020-7028 Species denotes patients Tax:9606
940 7453-7461 Species denotes patients Tax:9606
941 7528-7536 Species denotes patients Tax:9606
942 7665-7673 Species denotes patients Tax:9606
943 7708-7716 Species denotes patients Tax:9606
944 7824-7832 Species denotes patients Tax:9606
945 7385-7390 Chemical denotes ɑCD28
946 5722-5730 Disease denotes COVID-19 MESH:C000657245
947 6185-6193 Disease denotes COVID-19 MESH:C000657245
948 6207-6209 Disease denotes HD MESH:D006816
949 6262-6270 Disease denotes COVID-19 MESH:C000657245
950 6399-6407 Disease denotes COVID-19 MESH:C000657245
951 6481-6483 Disease denotes HD MESH:D006816
952 6941-6953 Disease denotes inflammation MESH:D007249
953 7011-7019 Disease denotes COVID-19 MESH:C000657245
954 7082-7084 Disease denotes HD MESH:D006816
955 7287-7295 Disease denotes COVID-19 MESH:C000657245
956 7444-7452 Disease denotes COVID-19 MESH:C000657245
957 7466-7468 Disease denotes HD MESH:D006816
958 7519-7527 Disease denotes COVID-19 MESH:C000657245
959 7815-7823 Disease denotes COVID-19 MESH:C000657245

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T139 0-4 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T140 10-19 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T141 337-341 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T142 812-820 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T143 842-844 Disease denotes HD http://purl.obolibrary.org/obo/MONDO_0007739
T144 995-997 Disease denotes RD http://purl.obolibrary.org/obo/MONDO_0009973
T145 1010-1012 Disease denotes HD http://purl.obolibrary.org/obo/MONDO_0007739
T146 1052-1060 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T147 1163-1171 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T148 1604-1606 Disease denotes HD http://purl.obolibrary.org/obo/MONDO_0007739
T149 1610-1612 Disease denotes RD http://purl.obolibrary.org/obo/MONDO_0009973
T150 2117-2125 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T151 2215-2217 Disease denotes HD http://purl.obolibrary.org/obo/MONDO_0007739
T152 2870-2878 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T153 2937-2947 Disease denotes infections http://purl.obolibrary.org/obo/MONDO_0005550
T154 3161-3169 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T155 3441-3443 Disease denotes HD http://purl.obolibrary.org/obo/MONDO_0007739
T156 3580-3588 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T157 3684-3686 Disease denotes HD http://purl.obolibrary.org/obo/MONDO_0007739
T158 3822-3830 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T159 3952-3954 Disease denotes HD http://purl.obolibrary.org/obo/MONDO_0007739
T160 3956-3958 Disease denotes RD http://purl.obolibrary.org/obo/MONDO_0009973
T161 3964-3972 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T162 4397-4399 Disease denotes HD http://purl.obolibrary.org/obo/MONDO_0007739
T163 4426-4428 Disease denotes RD http://purl.obolibrary.org/obo/MONDO_0009973
T164 4440-4448 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T165 4519-4521 Disease denotes BH http://purl.obolibrary.org/obo/MONDO_0010873
T166 4755-4763 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T167 4764-4773 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T168 4812-4820 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T169 4821-4830 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T170 5169-5177 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T171 5199-5201 Disease denotes HD http://purl.obolibrary.org/obo/MONDO_0007739
T172 5206-5208 Disease denotes RD http://purl.obolibrary.org/obo/MONDO_0009973
T173 5496-5504 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T174 5526-5528 Disease denotes HD http://purl.obolibrary.org/obo/MONDO_0007739
T175 5686-5694 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T176 5722-5730 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T177 6185-6193 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T178 6207-6209 Disease denotes HD http://purl.obolibrary.org/obo/MONDO_0007739
T179 6262-6270 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T180 6313-6317 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T181 6399-6407 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T182 6481-6483 Disease denotes HD http://purl.obolibrary.org/obo/MONDO_0007739
T183 6941-6953 Disease denotes inflammation http://purl.obolibrary.org/obo/MONDO_0021166
T184 7011-7019 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T185 7082-7084 Disease denotes HD http://purl.obolibrary.org/obo/MONDO_0007739
T186 7287-7295 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T187 7444-7452 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T188 7466-7468 Disease denotes HD http://purl.obolibrary.org/obo/MONDO_0007739
T189 7519-7527 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T190 7815-7823 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T306 53-56 http://purl.obolibrary.org/obo/PR_000001004 denotes CD4
T307 57-63 http://purl.obolibrary.org/obo/CL_0000084 denotes T cell
T308 78-88 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T309 92-95 http://purl.obolibrary.org/obo/PR_000001004 denotes CD4
T310 96-102 http://purl.obolibrary.org/obo/CL_0000084 denotes T cell
T311 145-148 http://purl.obolibrary.org/obo/PR_000001004 denotes CD4
T312 149-155 http://purl.obolibrary.org/obo/CL_0000084 denotes T cell
T313 181-184 http://purl.obolibrary.org/obo/CLO_0053438 denotes CD8
T314 185-192 http://purl.obolibrary.org/obo/CL_0000084 denotes T cells
T315 348-350 http://purl.obolibrary.org/obo/CLO_0050509 denotes 27
T316 391-397 http://purl.obolibrary.org/obo/PR_000001015 denotes CD45RA
T317 417-419 http://purl.obolibrary.org/obo/CLO_0001313 denotes 36
T318 426-435 http://purl.obolibrary.org/obo/CLO_0001658 denotes activated
T319 453-457 http://purl.obolibrary.org/obo/PR_000001408 denotes CD38
T320 465-474 http://purl.obolibrary.org/obo/CLO_0001658 denotes activated
T321 638-639 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T322 657-674 http://purl.obolibrary.org/obo/CL_0000895 denotes naïve CD4 T cells
T323 711-714 http://purl.obolibrary.org/obo/CLO_0002922 denotes EM2
T324 752-761 http://purl.obolibrary.org/obo/CLO_0001658 denotes activated
T325 890-891 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T326 948-957 http://purl.obolibrary.org/obo/CLO_0001658 denotes activated
T327 995-997 http://purl.obolibrary.org/obo/CLO_0008770 denotes RD
T328 1110-1114 http://purl.obolibrary.org/obo/PR_000001408 denotes CD38
T329 1127-1144 http://purl.obolibrary.org/obo/CL_0000895 denotes naïve CD4 T cells
T330 1251-1254 http://purl.obolibrary.org/obo/PR_000001004 denotes CD4
T331 1255-1261 http://purl.obolibrary.org/obo/CL_0000084 denotes T cell
T332 1320-1324 http://purl.obolibrary.org/obo/PR_000001408 denotes CD38
T333 1333-1338 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T334 1390-1393 http://purl.obolibrary.org/obo/CLO_0002922 denotes EM2
T335 1395-1398 http://purl.obolibrary.org/obo/CLO_0002923 denotes EM3
T336 1422-1423 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T337 1428-1429 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T338 1469-1479 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T339 1610-1612 http://purl.obolibrary.org/obo/CLO_0008770 denotes RD
T340 1642-1646 http://purl.obolibrary.org/obo/PR_000001408 denotes CD38
T341 1665-1682 http://purl.obolibrary.org/obo/CL_0000895 denotes naïve CD4 T cells
T342 1726-1743 http://purl.obolibrary.org/obo/CL_0000895 denotes naïve CD4 T cells
T343 1793-1810 http://purl.obolibrary.org/obo/CL_0000895 denotes naïve CD4 T cells
T344 1821-1825 http://purl.obolibrary.org/obo/PR_000001408 denotes CD38
T345 1867-1876 http://purl.obolibrary.org/obo/CLO_0001658 denotes activated
T346 1910-1920 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T347 1924-1927 http://purl.obolibrary.org/obo/PR_000001004 denotes CD4
T348 1928-1935 http://purl.obolibrary.org/obo/CL_0000084 denotes T cells
T349 1960-1970 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T350 1974-1977 http://purl.obolibrary.org/obo/CLO_0053438 denotes CD8
T351 1978-1985 http://purl.obolibrary.org/obo/CL_0000084 denotes T cells
T352 2059-2062 http://purl.obolibrary.org/obo/PR_000001004 denotes CD4
T353 2066-2069 http://purl.obolibrary.org/obo/CLO_0053438 denotes CD8
T354 2070-2076 http://purl.obolibrary.org/obo/CL_0000084 denotes T cell
T355 2173-2176 http://purl.obolibrary.org/obo/PR_000001004 denotes CD4
T356 2180-2183 http://purl.obolibrary.org/obo/CLO_0053438 denotes CD8
T357 2184-2191 http://purl.obolibrary.org/obo/CL_0000084 denotes T cells
T358 2297-2306 http://purl.obolibrary.org/obo/CLO_0001658 denotes activated
T359 2307-2310 http://purl.obolibrary.org/obo/PR_000001004 denotes CD4
T360 2311-2318 http://purl.obolibrary.org/obo/CL_0000084 denotes T cells
T361 2331-2334 http://purl.obolibrary.org/obo/CLO_0053438 denotes CD8
T362 2335-2342 http://purl.obolibrary.org/obo/CL_0000084 denotes T cells
T363 2354-2355 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T364 2403-2413 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T365 2417-2420 http://purl.obolibrary.org/obo/PR_000001004 denotes CD4
T366 2421-2428 http://purl.obolibrary.org/obo/CL_0000084 denotes T cells
T367 2441-2444 http://purl.obolibrary.org/obo/CLO_0053438 denotes CD8
T368 2445-2452 http://purl.obolibrary.org/obo/CL_0000084 denotes T cells
T369 2482-2486 http://purl.obolibrary.org/obo/PR_000001408 denotes CD38
T370 2499-2515 http://purl.obolibrary.org/obo/CL_0000895 denotes naïve CD4 T cell
T371 2602-2603 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T372 2625-2628 http://purl.obolibrary.org/obo/PR_000001004 denotes CD4
T373 2629-2635 http://purl.obolibrary.org/obo/CL_0000084 denotes T cell
T374 2636-2646 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T375 2702-2705 http://purl.obolibrary.org/obo/PR_000001004 denotes CD4
T376 2706-2712 http://purl.obolibrary.org/obo/CL_0000084 denotes T cell
T377 2713-2723 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T378 2790-2793 http://purl.obolibrary.org/obo/PR_000001004 denotes CD4
T379 2794-2800 http://purl.obolibrary.org/obo/CL_0000084 denotes T cell
T380 2849-2855 http://purl.obolibrary.org/obo/CL_0000084 denotes T cell
T381 2856-2866 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T382 2904-2907 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T383 3039-3045 http://purl.obolibrary.org/obo/CL_0000084 denotes T cell
T384 3073-3077 http://purl.obolibrary.org/obo/PR_000001408 denotes CD38
T385 3124-3127 http://purl.obolibrary.org/obo/PR_000001004 denotes CD4
T386 3128-3134 http://purl.obolibrary.org/obo/CL_0000084 denotes T cell
T387 3135-3145 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T388 3149-3150 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T389 3204-3207 http://purl.obolibrary.org/obo/PR_000001004 denotes CD4
T390 3208-3214 http://purl.obolibrary.org/obo/CL_0000084 denotes T cell
T391 3225-3226 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T392 3291-3294 http://purl.obolibrary.org/obo/PR_000001004 denotes CD4
T393 3295-3301 http://purl.obolibrary.org/obo/CL_0000084 denotes T cell
T394 3312-3313 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T395 3330-3333 http://purl.obolibrary.org/obo/PR_000001004 denotes CD4
T396 3334-3340 http://purl.obolibrary.org/obo/CL_0000084 denotes T cell
T397 3388-3393 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T398 3493-3498 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T399 3508-3525 http://purl.obolibrary.org/obo/CL_0000895 denotes naïve CD4 T cells
T400 3543-3546 http://purl.obolibrary.org/obo/CLO_0053438 denotes CD8
T401 3547-3554 http://purl.obolibrary.org/obo/CL_0000084 denotes T cells
T402 3625-3629 http://purl.obolibrary.org/obo/PR_000001408 denotes CD38
T403 3631-3636 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T404 3737-3741 http://purl.obolibrary.org/obo/PR_000001408 denotes CD38
T405 3743-3748 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T406 3764-3767 http://purl.obolibrary.org/obo/PR_000001004 denotes CD4
T407 3785-3788 http://purl.obolibrary.org/obo/CLO_0053438 denotes CD8
T408 3789-3796 http://purl.obolibrary.org/obo/CL_0000084 denotes T cells
T409 3882-3899 http://purl.obolibrary.org/obo/CL_0000895 denotes naïve CD4 T cells
T410 3929-3946 http://purl.obolibrary.org/obo/CL_0000895 denotes naïve CD4 T cells
T411 3956-3958 http://purl.obolibrary.org/obo/CLO_0008770 denotes RD
T412 4097-4113 http://purl.obolibrary.org/obo/CL_0000895 denotes naïve CD4 T cell
T413 4254-4271 http://purl.obolibrary.org/obo/CL_0000895 denotes naïve CD4 T cells
T414 4336-4337 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T415 4426-4428 http://purl.obolibrary.org/obo/CLO_0008770 denotes RD
T416 4509-4513 http://purl.obolibrary.org/obo/UBERON_0000473 denotes test
T417 4613-4616 http://purl.obolibrary.org/obo/PR_000001004 denotes CD4
T418 4617-4623 http://purl.obolibrary.org/obo/CL_0000084 denotes T cell
T419 4728-4731 http://purl.obolibrary.org/obo/PR_000001004 denotes CD4
T420 4732-4738 http://purl.obolibrary.org/obo/CL_0000084 denotes T cell
T421 4842-4843 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T422 4917-4921 http://purl.obolibrary.org/obo/PR_000001408 denotes CD38
T423 4979-4982 http://purl.obolibrary.org/obo/CLO_0053438 denotes CD8
T424 4983-4990 http://purl.obolibrary.org/obo/CL_0000084 denotes T cells
T425 5024-5027 http://purl.obolibrary.org/obo/PR_000001004 denotes CD4
T426 5028-5034 http://purl.obolibrary.org/obo/CL_0000084 denotes T cell
T427 5058-5059 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T428 5206-5208 http://purl.obolibrary.org/obo/CLO_0008770 denotes RD
T429 5255-5259 http://purl.obolibrary.org/obo/PR_000001408 denotes CD38
T430 5347-5350 http://purl.obolibrary.org/obo/PR_000001004 denotes CD4
T431 5351-5358 http://purl.obolibrary.org/obo/CL_0000084 denotes T cells
T432 5471-5476 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T433 5628-5637 http://purl.obolibrary.org/obo/CLO_0001658 denotes activated
T434 5652-5655 http://purl.obolibrary.org/obo/PR_000001004 denotes CD4
T435 5656-5663 http://purl.obolibrary.org/obo/CL_0000084 denotes T cells
T436 5705-5706 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T437 5930-5934 http://purl.obolibrary.org/obo/CLO_0053704 denotes IL-8
T438 5955-5961 http://purl.obolibrary.org/obo/CLO_0001044 denotes 11, 41
T439 6032-6038 http://purl.obolibrary.org/obo/CL_0000084 denotes T cell
T440 6098-6104 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T441 6138-6141 http://purl.obolibrary.org/obo/CLO_0052882 denotes CD3
T442 6138-6141 http://purl.obolibrary.org/obo/CLO_0053434 denotes CD3
T443 6173-6174 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T444 6279-6284 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T445 6279-6284 http://www.ebi.ac.uk/efo/EFO_0000296 denotes blood
T446 6343-6348 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T447 6343-6348 http://www.ebi.ac.uk/efo/EFO_0000296 denotes blood
T448 6421-6427 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T449 6528-6529 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T450 6698-6707 http://purl.obolibrary.org/obo/CLO_0001658 denotes activated
T451 6708-6715 http://purl.obolibrary.org/obo/CL_0000084 denotes T cells
T452 6829-6835 http://purl.obolibrary.org/obo/UBERON_0000473 denotes tested
T453 7210-7216 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T454 7270-7273 http://purl.obolibrary.org/obo/CLO_0053438 denotes CD8
T455 7274-7281 http://purl.obolibrary.org/obo/CL_0000084 denotes T cells
T456 7427-7430 http://purl.obolibrary.org/obo/CLO_0053438 denotes CD8
T457 7431-7438 http://purl.obolibrary.org/obo/CL_0000084 denotes T cells
T458 7607-7614 http://purl.obolibrary.org/obo/CL_0000084 denotes T cells
T459 7801-7802 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T460 7833-7836 http://purl.obolibrary.org/obo/CLO_0051582 denotes has

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T94 211-219 Chemical denotes effector http://purl.obolibrary.org/obo/CHEBI_35224
T95 398-401 Chemical denotes PD1 http://purl.obolibrary.org/obo/CHEBI_138655
T96 536-543 Chemical denotes antigen http://purl.obolibrary.org/obo/CHEBI_59132
T97 842-844 Chemical denotes HD http://purl.obolibrary.org/obo/CHEBI_73925
T98 995-997 Chemical denotes RD http://purl.obolibrary.org/obo/CHEBI_73812
T99 1010-1012 Chemical denotes HD http://purl.obolibrary.org/obo/CHEBI_73925
T100 1079-1084 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T101 1119-1121 Chemical denotes DR http://purl.obolibrary.org/obo/CHEBI_73445
T102 1329-1331 Chemical denotes DR http://purl.obolibrary.org/obo/CHEBI_73445
T103 1357-1365 Chemical denotes effector http://purl.obolibrary.org/obo/CHEBI_35224
T104 1386-1388 Chemical denotes EM http://purl.obolibrary.org/obo/CHEBI_73507
T105 1418-1420 Chemical denotes S3 http://purl.obolibrary.org/obo/CHEBI_29388
T106 1528-1531 Chemical denotes PD1 http://purl.obolibrary.org/obo/CHEBI_138655
T107 1604-1606 Chemical denotes HD http://purl.obolibrary.org/obo/CHEBI_73925
T108 1610-1612 Chemical denotes RD http://purl.obolibrary.org/obo/CHEBI_73812
T109 1625-1627 Chemical denotes Co http://purl.obolibrary.org/obo/CHEBI_27638
T110 1655-1657 Chemical denotes DR http://purl.obolibrary.org/obo/CHEBI_73445
T111 1830-1832 Chemical denotes DR http://purl.obolibrary.org/obo/CHEBI_73445
T112 2215-2217 Chemical denotes HD http://purl.obolibrary.org/obo/CHEBI_73925
T113 2491-2493 Chemical denotes DR http://purl.obolibrary.org/obo/CHEBI_73445
T114 2740-2747 Chemical denotes steroid http://purl.obolibrary.org/obo/CHEBI_35341
T115 3082-3084 Chemical denotes DR http://purl.obolibrary.org/obo/CHEBI_73445
T116 3441-3443 Chemical denotes HD http://purl.obolibrary.org/obo/CHEBI_73925
T117 3622-3624 Chemical denotes DR http://purl.obolibrary.org/obo/CHEBI_73445
T118 3684-3686 Chemical denotes HD http://purl.obolibrary.org/obo/CHEBI_73925
T119 3734-3736 Chemical denotes DR http://purl.obolibrary.org/obo/CHEBI_73445
T120 3952-3954 Chemical denotes HD http://purl.obolibrary.org/obo/CHEBI_73925
T121 3956-3958 Chemical denotes RD http://purl.obolibrary.org/obo/CHEBI_73812
T122 4049-4056 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T123 4390-4395 Chemical denotes donor http://purl.obolibrary.org/obo/CHEBI_17891
T124 4397-4399 Chemical denotes HD http://purl.obolibrary.org/obo/CHEBI_73925
T125 4419-4424 Chemical denotes donor http://purl.obolibrary.org/obo/CHEBI_17891
T126 4426-4428 Chemical denotes RD http://purl.obolibrary.org/obo/CHEBI_73812
T127 4927-4929 Chemical denotes DR http://purl.obolibrary.org/obo/CHEBI_73445
T128 4931-4934 Chemical denotes PD1 http://purl.obolibrary.org/obo/CHEBI_138655
T129 5199-5201 Chemical denotes HD http://purl.obolibrary.org/obo/CHEBI_73925
T130 5206-5208 Chemical denotes RD http://purl.obolibrary.org/obo/CHEBI_73812
T131 5251-5253 Chemical denotes DR http://purl.obolibrary.org/obo/CHEBI_73445
T132 5261-5264 Chemical denotes PD1 http://purl.obolibrary.org/obo/CHEBI_138655
T133 5332-5340 Chemical denotes effector http://purl.obolibrary.org/obo/CHEBI_35224
T134 5526-5528 Chemical denotes HD http://purl.obolibrary.org/obo/CHEBI_73925
T135 5916-5918 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T137 5924-5926 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T139 5930-5932 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T141 5936-5938 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T143 5947-5953 Chemical denotes CXCL10 http://purl.obolibrary.org/obo/CHEBI_138157
T144 6207-6209 Chemical denotes HD http://purl.obolibrary.org/obo/CHEBI_73925
T145 6428-6434 Chemical denotes CXCL10 http://purl.obolibrary.org/obo/CHEBI_138157
T146 6481-6483 Chemical denotes HD http://purl.obolibrary.org/obo/CHEBI_73925
T147 6559-6564 Chemical denotes CXCL9 http://purl.obolibrary.org/obo/CHEBI_138154
T148 6576-6578 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T150 6739-6741 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T152 6769-6774 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T153 6879-6881 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T155 7049-7055 Chemical denotes CXCL10 http://purl.obolibrary.org/obo/CHEBI_138157
T156 7070-7072 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T158 7082-7084 Chemical denotes HD http://purl.obolibrary.org/obo/CHEBI_73925
T159 7091-7093 Chemical denotes S4 http://purl.obolibrary.org/obo/CHEBI_29401
T160 7126-7132 Chemical denotes CXCL10 http://purl.obolibrary.org/obo/CHEBI_138157
T161 7466-7468 Chemical denotes HD http://purl.obolibrary.org/obo/CHEBI_73925
T162 7579-7581 Chemical denotes S4 http://purl.obolibrary.org/obo/CHEBI_29401
T163 7737-7739 Chemical denotes S4 http://purl.obolibrary.org/obo/CHEBI_29401

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T45 220-226 http://purl.obolibrary.org/obo/GO_0007613 denotes memory
T46 246-252 http://purl.obolibrary.org/obo/GO_0007613 denotes memory
T47 1366-1372 http://purl.obolibrary.org/obo/GO_0007613 denotes memory
T48 2629-2646 http://purl.obolibrary.org/obo/GO_0042110 denotes T cell activation
T49 2631-2646 http://purl.obolibrary.org/obo/GO_0001775 denotes cell activation
T50 2706-2723 http://purl.obolibrary.org/obo/GO_0042110 denotes T cell activation
T51 2708-2723 http://purl.obolibrary.org/obo/GO_0001775 denotes cell activation
T52 2849-2866 http://purl.obolibrary.org/obo/GO_0042110 denotes T cell activation
T53 2851-2866 http://purl.obolibrary.org/obo/GO_0001775 denotes cell activation
T54 3128-3145 http://purl.obolibrary.org/obo/GO_0042110 denotes T cell activation
T55 3130-3145 http://purl.obolibrary.org/obo/GO_0001775 denotes cell activation
T56 4617-4639 http://purl.obolibrary.org/obo/GO_0030217 denotes T cell differentiation
T57 4619-4639 http://purl.obolibrary.org/obo/GO_0030154 denotes cell differentiation
T58 5759-5780 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammatory response
T59 5916-5922 http://purl.obolibrary.org/obo/GO_0005152 denotes IL-1RA
T60 6576-6582 http://purl.obolibrary.org/obo/GO_0005152 denotes IL-1RA
T61 6941-6953 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T62 7070-7076 http://purl.obolibrary.org/obo/GO_0005152 denotes IL-1RA

LitCovid-PD-GlycoEpitope

Id Subject Object Predicate Lexical cue glyco_epitope_db_id
T8 711-714 GlycoEpitope denotes EM2 http://www.glycoepitope.jp/epitopes/AN0703
T9 1390-1393 GlycoEpitope denotes EM2 http://www.glycoepitope.jp/epitopes/AN0703

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T116 0-110 Sentence denotes SARS-CoV2 infection is associated with heterogeneous CD4 T cell responses and activation of CD4 T cell subsets
T117 111-278 Sentence denotes We next examined six well-defined CD4 T cell subsets as above for the CD8 T cells, including naïve, effector memory (EM1,2,3), central memory (CM), and EMRA (Fig. 3A).
T118 279-613 Sentence denotes Given the potential role of antibodies in the response to SARS-CoV2 (27, 29), we also analyzed circulating Tfh (CD45RA−PD1+CXCR5+ [cTfh] (36)) and activated circulating Tfh (CD38+ICOS+ [activated cTfh]), the latter of which may be more reflective of recent antigen encounter and emigration from the germinal center (37, 38) (Fig. 3A).
T119 614-734 Sentence denotes These analyses revealed a relative loss of naïve CD4 T cells compared to controls, but increased EM2 and EMRA (Fig. 3B).
T120 735-923 Sentence denotes The frequency of activated but not total cTfh was statistically increased in COVID-19 patients compared to HD, though this effect appeared to be driven by a subgroup of patients (Fig. 3B).
T121 924-1085 Sentence denotes It is worth noting that activated cTfh frequencies were also higher in RD compared to HD (Fig. 3B), perhaps reflecting residual COVID-19 responses in that group.
T122 1086-1270 Sentence denotes Frequencies of KI67+ or CD38+HLA-DR+ non-naïve CD4 T cells were increased in COVID-19 patients (Fig. 3, C and E); however, this change was not equivalent across all CD4 T cell subsets.
T123 1271-1431 Sentence denotes The most substantial increases in both KI67+ and CD38+HLA-DR+ cells were found in the effector memory populations (EM, EM2, EM3) and in cTfh (fig. S3, A and B).
T124 1432-1514 Sentence denotes Although some subjects had increased activation of EMRA, this was less pronounced.
T125 1515-1624 Sentence denotes In contrast, PD1 expression was increased in all other non-naïve populations compared to HD or RD (fig. S3C).
T126 1625-1755 Sentence denotes Co-expression of CD38 and HLA-DR by non-naïve CD4 T cells correlated with the frequency of KI67+ non-naïve CD4 T cells (fig. S3D).
T127 1756-1893 Sentence denotes Moreover, the frequency of total non-naïve CD4 T cells that were CD38+HLA-DR+ correlated with the frequency of activated cTfh (fig. S3E).
T128 1894-2004 Sentence denotes In general, the activation of CD4 T cells was correlated with the activation of CD8 T cells (Fig. 3, D and F).
T129 2005-2236 Sentence denotes However, whereas ~2/3 of patients had KI67+ non-naïve CD4 or CD8 T cell frequencies above controls, ~1/3 of the COVID-19 patients had no increase in frequency of KI67+ CD4 or CD8 T cells above that observed in HD (Fig. 3, D and F).
T130 2237-2471 Sentence denotes Moreover, although most patients had similar proportions of activated CD4 T cells compared to CD8 T cells, there was a subgroup of patients that had disproportionate activation of CD4 T cells compared to CD8 T cells (Fig. 3, D and F).
T131 2472-2668 Sentence denotes KI67+ and CD38+HLA-DR+ non-naïve CD4 T cell frequencies correlated with ferritin and with APACHE III score (fig. S3F), suggesting a relationship between CD4 T cell activation and disease severity.
T132 2669-2817 Sentence denotes Immunosuppression did not impact CD4 T cell activation; however, early steroid administration was weakly associated with CD4 T cell KI67 (fig. S3F).
T133 2818-3115 Sentence denotes Together, these data highlight T cell activation in COVID-19 patients similar to what has been observed in other acute infections or vaccinations (37, 39, 40), but also identify patients with high, low, or essentially no T cell response based on KI67+ or CD38+HLA-DR+ compared to control subjects.
T134 3116-3223 Sentence denotes Fig. 3 CD4 T cell activation in a subset of COVID-19 patients associates with distinct CD4 T cell subsets.
T135 3224-3445 Sentence denotes (A) Representative flow cytometry plots of the gating strategy for CD4 T cell subsets. (B) Frequencies of CD4 T cell subsets as indicated. (C) Frequencies of KI67+ cells; green line at upper decile of healthy donors (HD).
T136 3446-3688 Sentence denotes Representative flow cytometry plots. (D) KI67+ cells from non-naïve CD4 T cells versus non-naïve CD8 T cells, Spearman correlation of COVID-19 patients. (E) Frequencies of HLA-DR+CD38+ cells; green line at upper decile of healthy donors (HD).
T137 3689-4313 Sentence denotes Representative flow cytometry plots. (F) HLA-DR+CD38+ cells from non-naïve CD4 versus non-naïve CD8 T cells, Spearman correlation of COVID-19 patients. (G) (Top) Global viSNE projection of non-naïve CD4 T cells for all subjects pooled, non-naïve CD4 T cells from HD, RD, and COVID-19 patients concatenated and overlaid. (Bottom) viSNE projections of indicated protein expression. (H) viSNE projection of non-naïve CD4 T cell clusters identified by FlowSOM clustering. (I) Mean fluorescence intensity (MFI) as indicated, column-scaled z-score. (J) Percentage of non-naïve CD4 T cells from each cohort in each FlowSOM cluster.
T138 4314-4463 Sentence denotes Boxes represent IQR. (B, C, E, J) Each dot represents an individual healthy donor (HD; green), recovered donor (RD; blue), or COVID-19 patient (red).
T139 4464-4590 Sentence denotes Significance determined by unpaired Wilcoxon test with BH correction: *p < 0.05, **p < 0.01, ***p < 0.001, and ****p < 0.0001.
T140 4591-4808 Sentence denotes Projecting the global CD4 T cell differentiation patterns into the high-dimensional tSNE space again identified major alterations in the CD4 T cell response during COVID-19 infection compared to HDs and RDs (Fig. 3G).
T141 4809-4991 Sentence denotes In COVID-19 infection, there was a notable increase in density in tSNE regions that mapped to expression of CD38, HLA-DR, PD1, CD39, KI67, and CD95 (Fig. 3G), similar to CD8 T cells.
T142 4992-5106 Sentence denotes To gain more insight into these CD4 T cell changes, we again used a FlowSOM clustering approach (Fig. 3, H and I).
T143 5107-5391 Sentence denotes This analysis identified an increase in Clusters 13 and 14 in COVID-19 patients compared to HD and RD that represent populations expressing HLA-DR, CD38, PD1, KI67 and CD95, as well as Cluster 15 that contained Tbet+CX3CR1+ “effector-like” CD4 T cells (Fig. 3, I and J, and fig. S3G).
T144 5392-5547 Sentence denotes In contrast, this clustering approach identified reduction in CXCR5+ cTfh-like cells (Clusters 2, 3) in COVID-19 subjects compared to HD (Fig. 3, I and H).
T145 5548-5704 Sentence denotes Taken together, this multidimensional analysis revealed distinct populations of activated/proliferating CD4 T cells that were enriched in COVID-19 patients.
T146 5705-5963 Sentence denotes A key feature of COVID-19 disease is thought to be an inflammatory response that, at least in some patients, is linked to clinical disease manifestation (2, 4) and high levels of chemokines/cytokines, including IL-1RA, IL-6, IL-8, IL-10, and CXCL10 (11, 41).
T147 5964-6219 Sentence denotes To investigate the potential connection of inflammatory pathways to T cell responses, we performed 31-plex Luminex analysis on paired plasma and culture supernatants of anti-CD3/anti-CD28 stimulated PBMC from a subset of COVID-19 patients and HD controls.
T148 6220-6384 Sentence denotes Due to biosafety restrictions, only eight COVID-19 patient blood samples that were confirmed SARS-CoV2 RNA negative in the blood by PCR could be studied (fig. S4A).
T149 6385-6558 Sentence denotes Half of these COVID-19 patients had plasma CXCL10 concentrations that were ~15 fold higher than HD controls, whereas the remainder showed only a limited increase (fig. S4B).
T150 6559-6617 Sentence denotes CXCL9, CCL2, and IL-1RA were also significantly increased.
T151 6618-6738 Sentence denotes In contrast, chemokines involved in the recruitment of eosinophils (eotaxin) or activated T cells (CCL5) were decreased.
T152 6739-6968 Sentence denotes IL-6 was not elevated in this group of patients, in contrast to the subset of individuals tested clinically (fig. S1B), potentially because IL-6 was measured in the hospital setting often when systemic inflammation was suspected.
T153 6969-7236 Sentence denotes Following stimulation in vitro, PBMC from COVID-19 patients produced more CCL2, CXCL10, eotaxin, and IL-1RA than HD (fig. S4, C and D) and concentrations of CXCL10 and CCL2 correlated between the matched supernatant from stimulated PBMC and plasma samples (fig. S4E).
T154 7237-7369 Sentence denotes Finally, we investigated whether CD8 T cells from COVID-19 subjects were capable of producing IFNɣ following polyclonal stimulation.
T155 7370-7591 Sentence denotes Following ɑCD3+ɑCD28 stimulation, similar proportions of CD8 T cells from COVID-19 patients and HD controls produced IFNɣ, suggesting that PBMC from COVID-19 patients were responsive to TCR crosslinking (fig. S4, F to H).
T156 7592-7749 Sentence denotes The ability of T cells to produce IFNɣ following stimulation occurred in patients with increases in KI67 as well as patients with low KI67 (fig. S4, F to H).
T157 7750-7921 Sentence denotes Taken together, these data support the notion that a subgroup of COVID-19 patients has elevated systemic cytokines and chemokines, including myeloid recruiting chemokines.

2_test

Id Subject Object Predicate Lexical cue
32669297-32267220-135105200 348-350 32267220 denotes 27
32669297-32413330-135105201 352-354 32413330 denotes 29
32669297-31117010-135105202 417-419 31117010 denotes 36
32669297-25172499-135105203 599-601 25172499 denotes 38
32669297-32320677-135105204 2969-2971 32320677 denotes 39
32669297-28620653-135105205 2973-2975 28620653 denotes 40
32669297-32303591-135105206 5859-5860 32303591 denotes 2
32669297-32505227-135105207 5862-5863 32505227 denotes 4