PMC:7402624 / 11407-11994 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7402624","sourcedb":"PMC","sourceid":"7402624","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7402624","text":"We next asked if the changes in these lymphocyte populations were related to clinical metrics (Fig. 1H). Lower WBC counts were associated preferentially with lower frequencies of CD4 and CD8 T cells and increased non-T non-B, but not with B cells (Fig. 1H). These lower T cell counts were associated with clinical markers of inflammation including ferritin, D-dimer, and hsCRP (Fig. 1H), whereas altered B cell frequencies were not. Thus, hospitalized COVID-19 patients present with a complex constellation of clinical features that may be associated with altered lymphocyte populations.","tracks":[{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T60","span":{"begin":38,"end":48},"obj":"Body_part"},{"id":"T61","span":{"begin":193,"end":198},"obj":"Body_part"},{"id":"T62","span":{"begin":241,"end":246},"obj":"Body_part"},{"id":"T63","span":{"begin":272,"end":276},"obj":"Body_part"},{"id":"T64","span":{"begin":406,"end":410},"obj":"Body_part"},{"id":"T65","span":{"begin":564,"end":574},"obj":"Body_part"}],"attributes":[{"id":"A60","pred":"fma_id","subj":"T60","obj":"http://purl.org/sig/ont/fma/fma62863"},{"id":"A61","pred":"fma_id","subj":"T61","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A62","pred":"fma_id","subj":"T62","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A63","pred":"fma_id","subj":"T63","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A64","pred":"fma_id","subj":"T64","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A65","pred":"fma_id","subj":"T65","obj":"http://purl.org/sig/ont/fma/fma62863"},{"subj":"T60","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T61","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T62","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T63","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T64","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T65","pred":"source","obj":"LitCovid-PD-FMA-UBERON"}]},{"project":"LitCovid-PubTator","denotations":[{"id":"323","span":{"begin":179,"end":182},"obj":"Gene"},{"id":"324","span":{"begin":187,"end":190},"obj":"Gene"},{"id":"325","span":{"begin":461,"end":469},"obj":"Species"},{"id":"326","span":{"begin":325,"end":337},"obj":"Disease"},{"id":"327","span":{"begin":452,"end":460},"obj":"Disease"}],"attributes":[{"id":"A323","pred":"tao:has_database_id","subj":"323","obj":"Gene:920"},{"id":"A324","pred":"tao:has_database_id","subj":"324","obj":"Gene:925"},{"id":"A325","pred":"tao:has_database_id","subj":"325","obj":"Tax:9606"},{"id":"A326","pred":"tao:has_database_id","subj":"326","obj":"MESH:D007249"},{"id":"A327","pred":"tao:has_database_id","subj":"327","obj":"MESH:C000657245"},{"subj":"323","pred":"source","obj":"LitCovid-PubTator"},{"subj":"324","pred":"source","obj":"LitCovid-PubTator"},{"subj":"325","pred":"source","obj":"LitCovid-PubTator"},{"subj":"326","pred":"source","obj":"LitCovid-PubTator"},{"subj":"327","pred":"source","obj":"LitCovid-PubTator"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}]},{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T86","span":{"begin":325,"end":337},"obj":"Disease"},{"id":"T87","span":{"begin":452,"end":460},"obj":"Disease"}],"attributes":[{"id":"A86","pred":"mondo_id","subj":"T86","obj":"http://purl.obolibrary.org/obo/MONDO_0021166"},{"id":"A87","pred":"mondo_id","subj":"T87","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"subj":"T86","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T87","pred":"source","obj":"LitCovid-PD-MONDO"}]},{"project":"LitCovid-PD-CLO","denotations":[{"id":"T132","span":{"begin":179,"end":182},"obj":"http://purl.obolibrary.org/obo/PR_000001004"},{"id":"T133","span":{"begin":187,"end":190},"obj":"http://purl.obolibrary.org/obo/CLO_0053438"},{"id":"T134","span":{"begin":191,"end":198},"obj":"http://purl.obolibrary.org/obo/CL_0000084"},{"id":"T135","span":{"begin":223,"end":246},"obj":"http://purl.obolibrary.org/obo/CLO_0001869"},{"id":"T136","span":{"begin":270,"end":276},"obj":"http://purl.obolibrary.org/obo/CL_0000084"},{"id":"T137","span":{"begin":404,"end":410},"obj":"http://purl.obolibrary.org/obo/CL_0000236"},{"id":"T138","span":{"begin":483,"end":484},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"}],"attributes":[{"subj":"T132","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T133","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T134","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T135","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T136","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T137","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T138","pred":"source","obj":"LitCovid-PD-CLO"}]},{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T35","span":{"begin":100,"end":102},"obj":"Chemical"},{"id":"T36","span":{"begin":253,"end":255},"obj":"Chemical"},{"id":"T37","span":{"begin":383,"end":385},"obj":"Chemical"}],"attributes":[{"id":"A35","pred":"chebi_id","subj":"T35","obj":"http://purl.obolibrary.org/obo/CHEBI_49637"},{"id":"A36","pred":"chebi_id","subj":"T36","obj":"http://purl.obolibrary.org/obo/CHEBI_49637"},{"id":"A37","pred":"chebi_id","subj":"T37","obj":"http://purl.obolibrary.org/obo/CHEBI_49637"},{"subj":"T35","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T36","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T37","pred":"source","obj":"LitCovid-PD-CHEBI"}]},{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T28","span":{"begin":325,"end":337},"obj":"http://purl.obolibrary.org/obo/GO_0006954"}],"attributes":[{"subj":"T28","pred":"source","obj":"LitCovid-PD-GO-BP"}]},{"project":"LitCovid-sentences","denotations":[{"id":"T76","span":{"begin":0,"end":104},"obj":"Sentence"},{"id":"T77","span":{"begin":105,"end":257},"obj":"Sentence"},{"id":"T78","span":{"begin":258,"end":432},"obj":"Sentence"},{"id":"T79","span":{"begin":433,"end":587},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T76","pred":"source","obj":"LitCovid-sentences"},{"subj":"T77","pred":"source","obj":"LitCovid-sentences"},{"subj":"T78","pred":"source","obj":"LitCovid-sentences"},{"subj":"T79","pred":"source","obj":"LitCovid-sentences"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCovid-PD-FMA-UBERON","color":"#d0ec93","default":true},{"id":"LitCovid-PubTator","color":"#ec93ea"},{"id":"LitCovid-PD-MONDO","color":"#93ecd3"},{"id":"LitCovid-PD-CLO","color":"#ecb993"},{"id":"LitCovid-PD-CHEBI","color":"#9f93ec"},{"id":"LitCovid-PD-GO-BP","color":"#a0ec93"},{"id":"LitCovid-sentences","color":"#ec93ba"}]}]}}