PMC:7402624 / 112-1038
Annnotations
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T1 | 308-312 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
| T2 | 319-323 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
| T3 | 390-394 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
| T4 | 450-461 | Body_part | denotes | plasmablast | http://purl.org/sig/ont/fma/fma84371 |
| T5 | 503-508 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T6 | 540-550 | Body_part | denotes | lymphocyte | http://purl.org/sig/ont/fma/fma62863 |
LitCovid-PubTator
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
|---|---|---|---|---|---|
| 12 | 45-50 | Species | denotes | human | Tax:9606 |
| 13 | 132-140 | Species | denotes | patients | Tax:9606 |
| 14 | 351-359 | Species | denotes | patients | Tax:9606 |
| 15 | 375-383 | Species | denotes | patients | Tax:9606 |
| 16 | 0-8 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 17 | 123-131 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 18 | 430-445 | Disease | denotes | viral infection | MESH:D001102 |
| 19 | 917-925 | Disease | denotes | COVID-19 | MESH:C000657245 |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T2 | 0-8 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T3 | 123-131 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T4 | 430-445 | Disease | denotes | viral infection | http://purl.obolibrary.org/obo/MONDO_0005108 |
| T5 | 436-445 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
| T6 | 917-925 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 22-23 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T2 | 45-50 | http://purl.obolibrary.org/obo/NCBITaxon_9606 | denotes | human |
| T3 | 75-80 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T4 | 292-302 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activation |
| T5 | 306-312 | http://purl.obolibrary.org/obo/CL_0000084 | denotes | T cell |
| T6 | 317-323 | http://purl.obolibrary.org/obo/CL_0000236 | denotes | B cell |
| T7 | 335-336 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T8 | 361-362 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | A |
| T9 | 388-394 | http://purl.obolibrary.org/obo/CL_0000084 | denotes | T cell |
| T10 | 395-405 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activation |
| T11 | 501-508 | http://purl.obolibrary.org/obo/CL_0000236 | denotes | B cells |
| T12 | 551-561 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activation |
LitCovid-PD-GO-BP
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 51-67 | http://purl.obolibrary.org/obo/GO_0006955 | denotes | immune responses |
| T2 | 388-405 | http://purl.obolibrary.org/obo/GO_0042110 | denotes | T cell activation |
| T3 | 390-405 | http://purl.obolibrary.org/obo/GO_0001775 | denotes | cell activation |
| T4 | 430-445 | http://purl.obolibrary.org/obo/GO_0016032 | denotes | viral infection |
| T5 | 540-561 | http://purl.obolibrary.org/obo/GO_0046649 | denotes | lymphocyte activation |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T3 | 0-106 | Sentence | denotes | COVID-19 is currently a global pandemic, but human immune responses to the virus remain poorly understood. |
| T4 | 107-221 | Sentence | denotes | We analyzed 125 COVID-19 patients, and compared recovered to healthy individuals using high dimensional cytometry. |
| T5 | 222-360 | Sentence | denotes | Integrated analysis of ~200 immune and ~50 clinical features revealed activation of T cell and B cell subsets in a proportion of patients. |
| T6 | 361-509 | Sentence | denotes | A subgroup of patients had T cell activation characteristic of acute viral infection and plasmablast responses reaching >30% of circulating B cells. |
| T7 | 510-596 | Sentence | denotes | However, another subgroup had lymphocyte activation comparable to uninfected subjects. |
| T8 | 597-714 | Sentence | denotes | Stable versus dynamic immunological signatures were identified and linked to trajectories of disease severity change. |
| T9 | 715-828 | Sentence | denotes | These analyses identified three “immunotypes” associated with poor clinical trajectories versus improving health. |
| T10 | 829-926 | Sentence | denotes | These immunotypes may have implications for the design of therapeutics and vaccines for COVID-19. |