PMC:7396557 / 87795-89806 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7396557","sourcedb":"PMC","sourceid":"7396557","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7396557","text":"Y. Z. Zhang et al. observed that SMI had strong anti-shock and neuroprotective properties in LPS-induced shock, possibly due to inhibition of brain lipid peroxidation and improvement of SOD activity (Zhang Y. Z. et al., 2010). SMI suppressed apoptosis of lung tissue cells during pulmonary ischemia/reperfusion injury in rabbits, resulting in attenuation of pneumocyte injury by raising NO levels, lowering oxygen free radical levels, and decreasing lipid peroxidation (Lin et al., 2007). It has also been reported that SMI reduced expression of NF-κB and activity of inducible nitric oxide synthase (iNOS) in lung tissues of rats poisoned by paraquat, and significantly alleviated erythrocyte diapedesis in the alveolar space (Liu et al., 2009). Research by Shuhua Xu et al. showed that SMI improved cardiac function and significantly improved hemodynamics in rats with cardiac failure. In addition, it improved the oxygen supply to tissues and the capacity of the tissues to use oxygen, thus, improving oxygen metabolism (Xu and Liu, 2010). SMI also inhibited expression of ICAM-1 and vascular cell adhesion molecule 1 (VCAM-1) to alleviate inflammatory infiltration following ischemia/reperfusion, and alleviated myocardial ischemia/reperfusion injury caused by multiple inflammatory responses (Liu et al., 2015). It also inhibited generation of inflammatory cytokines in rats subjected to ischemia/reperfusion, reduced serum expression of TNF-α, IL-6, IL-8, etc., thus, alleviating inflammatory factor-induced cardiomyocyte injury and improving immune function (Wang et al., 2015). Research by Xuan Liu et al. discovered that SMI inhibited MCP-1, which indicated that SMI might be important in the inhibition of monocyte and macrophage activation (Liu et al., 2015). Lihua Du discovered that SMI significantly increased the weights of thymus and spleen in mice, raised serum IgG levels and the number of T cells, enhanced the phagocytic function of macrophages and had a significant immunomodulatory 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