
PMC:7394275 / 17860-20076
Annnotations
LitCovid-PMC-OGER-BB
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T264 | 0-8 | SP_7 | denotes | COVID-19 |
T265 | 23-28 | SP_6;NCBITaxon:9606 | denotes | human |
T266 | 46-51 | NCBITaxon:10239 | denotes | virus |
T267 | 83-86 | PR:000001004 | denotes | CD4 |
T268 | 89-101 | CL:0000084 | denotes | T-lymphocyte |
T269 | 149-155 | UBERON:0002405 | denotes | immune |
T270 | 345-357 | NCBITaxon:106841 | denotes | Cryptococcus |
T271 | 358-365 | NCBITaxon:species | denotes | species |
T272 | 376-378 | NCBITaxon:7719 | denotes | C. |
T273 | 379-389 | NCBITaxon:5478 | denotes | neoformans |
T274 | 394-396 | NCBITaxon:7719 | denotes | C. |
T275 | 397-403 | NCBITaxon:5478 | denotes | gattii |
T276 | 404-411 | NCBITaxon:species | denotes | species |
T277 | 687-706 | UBERON:0001359 | denotes | cerebrospinal fluid |
T278 | 708-711 | UBERON:0001359 | denotes | CSF |
T279 | 808-820 | NCBITaxon:106841 | denotes | Cryptococcus |
T280 | 838-845 | GO:0007114 | denotes | budding |
T281 | 947-951 | CHEBI:2509;CHEBI:2509 | denotes | agar |
T282 | 1108-1112 | GO:0040007 | denotes | grow |
T283 | 1171-1186 | CHEBI:18154;CHEBI:18154 | denotes | polysaccharides |
T284 | 1239-1250 | UBERON:0006314 | denotes | body fluids |
T285 | 1259-1264 | UBERON:0001977 | denotes | serum |
T286 | 1292-1298 | UBERON:0000479 | denotes | tissue |
T287 | 1330-1337 | CHEBI:59132;CHEBI:59132 | denotes | antigen |
T288 | 1339-1343 | PR:000003817 | denotes | CrAg |
T289 | 1584-1595 | UBERON:0001004 | denotes | respiratory |
T290 | 1619-1632 | UBERON:0001087 | denotes | pleural fluid |
T291 | 1637-1643 | UBERON:0007311 | denotes | sputum |
T292 | 1840-1846 | NCBITaxon:4751 | denotes | fungal |
T293 | 2027-2046 | UBERON:0001359 | denotes | cerebrospinal fluid |
T294 | 2076-2083 | CHEBI:59132;CHEBI:59132 | denotes | antigen |
T295 | 2161-2183 | UBERON:0001017 | denotes | central nervous system |
T3792 | 0-8 | SP_7 | denotes | COVID-19 |
T4250 | 23-28 | SP_6;NCBITaxon:9606 | denotes | human |
T80532 | 46-51 | NCBITaxon:10239 | denotes | virus |
T69080 | 83-86 | PR:000001004 | denotes | CD4 |
T57693 | 89-101 | CL:0000084 | denotes | T-lymphocyte |
T48016 | 149-155 | UBERON:0002405 | denotes | immune |
T2122 | 345-357 | NCBITaxon:106841 | denotes | Cryptococcus |
T52255 | 358-365 | NCBITaxon:species | denotes | species |
T50703 | 376-378 | NCBITaxon:7719 | denotes | C. |
T20343 | 379-389 | NCBITaxon:5478 | denotes | neoformans |
T17477 | 394-396 | NCBITaxon:7719 | denotes | C. |
T10330 | 397-403 | NCBITaxon:5478 | denotes | gattii |
T93842 | 404-411 | NCBITaxon:species | denotes | species |
T82098 | 687-706 | UBERON:0001359 | denotes | cerebrospinal fluid |
T15522 | 708-711 | UBERON:0001359 | denotes | CSF |
T58192 | 808-820 | NCBITaxon:106841 | denotes | Cryptococcus |
T54110 | 838-845 | GO:0007114 | denotes | budding |
T1942 | 947-951 | CHEBI:2509;CHEBI:2509 | denotes | agar |
T86453 | 1108-1112 | GO:0040007 | denotes | grow |
T63138 | 1171-1186 | CHEBI:18154;CHEBI:18154 | denotes | polysaccharides |
T61182 | 1239-1250 | UBERON:0006314 | denotes | body fluids |
T62464 | 1259-1264 | UBERON:0001977 | denotes | serum |
T61960 | 1292-1298 | UBERON:0000479 | denotes | tissue |
T30703 | 1330-1337 | CHEBI:59132;CHEBI:59132 | denotes | antigen |
T90969 | 1339-1343 | PR:000003817 | denotes | CrAg |
T24495 | 1584-1595 | UBERON:0001004 | denotes | respiratory |
T44771 | 1619-1632 | UBERON:0001087 | denotes | pleural fluid |
T43630 | 1637-1643 | UBERON:0007311 | denotes | sputum |
T49362 | 1840-1846 | NCBITaxon:4751 | denotes | fungal |
T52785 | 2027-2046 | UBERON:0001359 | denotes | cerebrospinal fluid |
T36771 | 2076-2083 | CHEBI:59132;CHEBI:59132 | denotes | antigen |
T28958 | 2161-2183 | UBERON:0001017 | denotes | central nervous system |
LitCovid-PD-FMA-UBERON
Id | Subject | Object | Predicate | Lexical cue | fma_id |
---|---|---|---|---|---|
T48 | 53-56 | Body_part | denotes | HIV | http://purl.org/sig/ont/fma/fma278683 |
T49 | 83-101 | Body_part | denotes | CD4 + T-lymphocyte | http://purl.org/sig/ont/fma/fma70572 |
T50 | 89-101 | Body_part | denotes | T-lymphocyte | http://purl.org/sig/ont/fma/fma62870 |
T51 | 114-119 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
T52 | 687-706 | Body_part | denotes | cerebrospinal fluid | http://purl.org/sig/ont/fma/fma20935 |
T53 | 708-711 | Body_part | denotes | CSF | http://purl.org/sig/ont/fma/fma20935 |
T54 | 1171-1186 | Body_part | denotes | polysaccharides | http://purl.org/sig/ont/fma/fma82746 |
T55 | 1239-1250 | Body_part | denotes | body fluids | http://purl.org/sig/ont/fma/fma280556 |
T56 | 1239-1243 | Body_part | denotes | body | http://purl.org/sig/ont/fma/fma256135 |
T57 | 1259-1264 | Body_part | denotes | serum | http://purl.org/sig/ont/fma/fma63083 |
T58 | 1266-1269 | Body_part | denotes | CSF | http://purl.org/sig/ont/fma/fma20935 |
T59 | 1292-1298 | Body_part | denotes | tissue | http://purl.org/sig/ont/fma/fma9637 |
T60 | 1619-1632 | Body_part | denotes | pleural fluid | http://purl.org/sig/ont/fma/fma12273 |
T61 | 1637-1643 | Body_part | denotes | sputum | http://purl.org/sig/ont/fma/fma312401 |
T62 | 1852-1855 | Body_part | denotes | DNA | http://purl.org/sig/ont/fma/fma74412 |
T63 | 2027-2046 | Body_part | denotes | cerebrospinal fluid | http://purl.org/sig/ont/fma/fma20935 |
T64 | 2048-2051 | Body_part | denotes | CSF | http://purl.org/sig/ont/fma/fma20935 |
T65 | 2161-2183 | Body_part | denotes | central nervous system | http://purl.org/sig/ont/fma/fma55675 |
LitCovid-PD-UBERON
Id | Subject | Object | Predicate | Lexical cue | uberon_id |
---|---|---|---|---|---|
T30 | 687-706 | Body_part | denotes | cerebrospinal fluid | http://purl.obolibrary.org/obo/UBERON_0001359 |
T31 | 1259-1264 | Body_part | denotes | serum | http://purl.obolibrary.org/obo/UBERON_0001977 |
T32 | 1292-1298 | Body_part | denotes | tissue | http://purl.obolibrary.org/obo/UBERON_0000479 |
T33 | 1619-1632 | Body_part | denotes | pleural fluid | http://purl.obolibrary.org/obo/UBERON_0001087 |
T34 | 1637-1643 | Body_part | denotes | sputum | http://purl.obolibrary.org/obo/UBERON_0007311 |
T35 | 2027-2046 | Body_part | denotes | cerebrospinal fluid | http://purl.obolibrary.org/obo/UBERON_0001359 |
T36 | 2161-2183 | Body_part | denotes | central nervous system | http://purl.obolibrary.org/obo/UBERON_0001017 |
T37 | 2169-2183 | Body_part | denotes | nervous system | http://purl.obolibrary.org/obo/UBERON_0001016 |
LitCovid-PubTator
Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
---|---|---|---|---|---|
553 | 83-86 | Gene | denotes | CD4 | Gene:920 |
554 | 120-122 | Gene | denotes | μL | Gene:4591 |
555 | 9-17 | Species | denotes | patients | Tax:9606 |
556 | 376-389 | Species | denotes | C. neoformans | Tax:5207 |
557 | 394-403 | Species | denotes | C. gattii | Tax:552467 |
558 | 859-865 | Species | denotes | yeasts | Tax:4932 |
559 | 1040-1048 | Species | denotes | patients | Tax:9606 |
560 | 1673-1688 | Species | denotes | Cryptococcus is | Tax:1198465 |
561 | 2108-2116 | Species | denotes | patients | Tax:9606 |
562 | 345-357 | Species | denotes | Cryptococcus | Tax:5207 |
563 | 808-820 | Species | denotes | Cryptococcus | Tax:5207 |
564 | 1114-1126 | Species | denotes | Cryptococcus | Tax:5207 |
565 | 1190-1202 | Species | denotes | Cryptococcus | Tax:5207 |
566 | 2123-2135 | Species | denotes | Cryptococcus | Tax:5207 |
567 | 731-740 | Chemical | denotes | India ink | MESH:C028433 |
568 | 928-951 | Chemical | denotes | Sabouraud dextrose agar | |
569 | 0-8 | Disease | denotes | COVID-19 | MESH:C000657245 |
570 | 23-67 | Disease | denotes | human immunodeficiency virus (HIV) infection | MESH:D015658 |
571 | 184-198 | Disease | denotes | cryptococcosis | MESH:D003453 |
572 | 230-249 | Disease | denotes | meningoencephalitis | MESH:D008590 |
573 | 308-322 | Disease | denotes | cryptococcosis | MESH:D003453 |
574 | 430-444 | Disease | denotes | cryptococcosis | MESH:D003453 |
575 | 552-561 | Disease | denotes | infection | MESH:D007239 |
576 | 657-671 | Disease | denotes | cryptococcosis | MESH:D003453 |
577 | 1788-1802 | Disease | denotes | cryptococcosis | MESH:D003453 |
578 | 1981-1995 | Disease | denotes | cryptococcosis | MESH:D003453 |
579 | 2192-2215 | Disease | denotes | cryptococcal meningitis | MESH:D016919 |
LitCovid-PD-MONDO
Id | Subject | Object | Predicate | Lexical cue | mondo_id |
---|---|---|---|---|---|
T171 | 0-8 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
T172 | 29-45 | Disease | denotes | immunodeficiency | http://purl.obolibrary.org/obo/MONDO_0021094 |
T173 | 52-67 | Disease | denotes | (HIV) infection | http://purl.obolibrary.org/obo/MONDO_0005109 |
T174 | 58-67 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
T175 | 184-198 | Disease | denotes | cryptococcosis | http://purl.obolibrary.org/obo/MONDO_0005724 |
T176 | 230-249 | Disease | denotes | meningoencephalitis | http://purl.obolibrary.org/obo/MONDO_0005845 |
T177 | 308-322 | Disease | denotes | cryptococcosis | http://purl.obolibrary.org/obo/MONDO_0005724 |
T178 | 430-444 | Disease | denotes | cryptococcosis | http://purl.obolibrary.org/obo/MONDO_0005724 |
T179 | 552-561 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
T180 | 657-671 | Disease | denotes | cryptococcosis | http://purl.obolibrary.org/obo/MONDO_0005724 |
T181 | 1788-1802 | Disease | denotes | cryptococcosis | http://purl.obolibrary.org/obo/MONDO_0005724 |
T182 | 1981-1995 | Disease | denotes | cryptococcosis | http://purl.obolibrary.org/obo/MONDO_0005724 |
T183 | 2192-2215 | Disease | denotes | cryptococcal meningitis | http://purl.obolibrary.org/obo/MONDO_0005723 |
T184 | 2205-2215 | Disease | denotes | meningitis | http://purl.obolibrary.org/obo/MONDO_0004796|http://purl.obolibrary.org/obo/MONDO_0021108 |
LitCovid-PD-CLO
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T105 | 23-28 | http://purl.obolibrary.org/obo/NCBITaxon_9606 | denotes | human |
T106 | 46-51 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
T107 | 83-86 | http://purl.obolibrary.org/obo/PR_000001004 | denotes | CD4 |
T108 | 114-119 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
T109 | 465-466 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T110 | 760-761 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T111 | 955-966 | http://purl.obolibrary.org/obo/CLO_0001282 | denotes | 30 °C for 7 |
T112 | 1239-1250 | http://purl.obolibrary.org/obo/UBERON_0006314 | denotes | body fluids |
T113 | 1355-1360 | http://purl.obolibrary.org/obo/UBERON_0000473 | denotes | tests |
T114 | 1410-1414 | http://purl.obolibrary.org/obo/UBERON_0000473 | denotes | test |
T115 | 1416-1419 | http://purl.obolibrary.org/obo/CLO_0007247 | denotes | LAT |
T116 | 1773-1774 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T117 | 1836-1839 | http://purl.obolibrary.org/obo/NCBITaxon_9596 | denotes | pan |
T118 | 1969-1970 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T119 | 2005-2006 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T120 | 2161-2183 | http://purl.obolibrary.org/obo/UBERON_0001017 | denotes | central nervous system |
T121 | 2161-2183 | http://www.ebi.ac.uk/efo/EFO_0000302 | denotes | central nervous system |
T122 | 2161-2183 | http://www.ebi.ac.uk/efo/EFO_0000908 | denotes | central nervous system |
LitCovid-PD-CHEBI
Id | Subject | Object | Predicate | Lexical cue | chebi_id |
---|---|---|---|---|---|
T104 | 938-946 | Chemical | denotes | dextrose | http://purl.obolibrary.org/obo/CHEBI_17634 |
T105 | 947-951 | Chemical | denotes | agar | http://purl.obolibrary.org/obo/CHEBI_2509 |
T106 | 1068-1078 | Chemical | denotes | antifungal | http://purl.obolibrary.org/obo/CHEBI_35718 |
T107 | 1171-1186 | Chemical | denotes | polysaccharides | http://purl.obolibrary.org/obo/CHEBI_18154 |
T108 | 1271-1274 | Chemical | denotes | BAL | http://purl.obolibrary.org/obo/CHEBI_64198 |
T109 | 1330-1337 | Chemical | denotes | antigen | http://purl.obolibrary.org/obo/CHEBI_59132 |
T110 | 1493-1496 | Chemical | denotes | LFA | http://purl.obolibrary.org/obo/CHEBI_139482 |
T111 | 1614-1617 | Chemical | denotes | BAL | http://purl.obolibrary.org/obo/CHEBI_64198 |
T112 | 1852-1855 | Chemical | denotes | DNA | http://purl.obolibrary.org/obo/CHEBI_16991 |
T113 | 1939-1944 | Chemical | denotes | probe | http://purl.obolibrary.org/obo/CHEBI_50406 |
T114 | 2076-2083 | Chemical | denotes | antigen | http://purl.obolibrary.org/obo/CHEBI_59132 |
LitCovid-PD-GO-BP
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T3 | 838-845 | http://purl.obolibrary.org/obo/GO_0007114 | denotes | budding |
T4 | 1396-1409 | http://purl.obolibrary.org/obo/GO_0007157 | denotes | agglutination |
T5 | 1396-1409 | http://purl.obolibrary.org/obo/GO_0000752 | denotes | agglutination |
LitCovid-sentences
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T88 | 0-255 | Sentence | denotes | COVID-19 patients with human immunodeficiency virus (HIV) infection accompanied by CD4 + T-lymphocyte count < 200 cells/μL, allo-HSCT, SOT, or other immune impaired are susceptible to cryptococcosis which predominantly present as meningoencephalitis [38]. |
T89 | 256-519 | Sentence | denotes | Given the complexities surrounding the diagnosis of cryptococcosis and identification of Cryptococcus species including C. neoformans and C. gattii species, the diagnosis of cryptococcosis is usually based on a combination of clinical and laboratory confirmation. |
T90 | 520-644 | Sentence | denotes | The methods used to confirm the infection are culture, direct microscopy, histopathology, serology, and molecular detection. |
T91 | 645-887 | Sentence | denotes | To diagnose cryptococcosis, specimen from cerebrospinal fluid (CSF) can be mixed with India ink and observed under a microscope that the distinctive structure for Cryptococcus spp. with narrow budding encapsulated yeasts usually can be found. |
T92 | 888-1015 | Sentence | denotes | Samples for culture should be placed on Sabouraud dextrose agar at 30 °C for 7 days, in aerobic conditions, and observed daily. |
T93 | 1016-1113 | Sentence | denotes | Moreover, cultures from patients receiving systemic antifungal therapy might need longer to grow. |
T94 | 1114-1161 | Sentence | denotes | Cryptococcus appears as mucoid creamy colonies. |
T95 | 1162-1299 | Sentence | denotes | Capsular polysaccharides of Cryptococcus can be detected and quantified from body fluids such as serum, CSF, BAL, or pathological tissue. |
T96 | 1300-1498 | Sentence | denotes | Three formats of cryptococcal antigen (CrAg) detection tests are currently available: the latex agglutination test (LAT), the enzyme-linked immunoassay (EIA), and the lateral flow immunoassay (LFA). |
T97 | 1499-1649 | Sentence | denotes | These methods are rapid, sensitive, and specific, but have not been standardized for respiratory specimens such as BAL, pleural fluid, or sputum [32]. |
T98 | 1650-1803 | Sentence | denotes | Molecular detection of Cryptococcus is required in specific situations where other diagnostic tools have failed to confirm a diagnosis of cryptococcosis. |
T99 | 1804-1963 | Sentence | denotes | These molecular methods include pan-fungal PCR, DNA sequencing for identification, multiplex PCR, isothermal amplification method, and probe-based microarrays. |
T100 | 1964-2122 | Sentence | denotes | Once a diagnosis cryptococcosis is made, a lumbar puncture and cerebrospinal fluid (CSF) examination (including antigen) are recommended in all patients [39]. |
T101 | 2123-2216 | Sentence | denotes | Cryptococcus can disseminate into the central nervous system causing cryptococcal meningitis. |
LitCovid-PD-HP
Id | Subject | Object | Predicate | Lexical cue | hp_id |
---|---|---|---|---|---|
T18 | 29-45 | Phenotype | denotes | immunodeficiency | http://purl.obolibrary.org/obo/HP_0002721 |
T19 | 2192-2215 | Phenotype | denotes | cryptococcal meningitis | http://purl.obolibrary.org/obo/HP_0032160 |
2_test
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
32737747-30329097-73473628 | 251-253 | 30329097 | denotes | 38 |
32737747-28882009-73473629 | 1645-1647 | 28882009 | denotes | 32 |
32737747-29663539-73473630 | 2118-2120 | 29663539 | denotes | 39 |