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PMC:7388103 / 7806-9076 JSONTXT

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LitCovid_Glycan-Motif-Structure

Id Subject Object Predicate Lexical cue
T33 81-88 https://glytoucan.org/Structures/Glycans/G00021MO denotes heparin
T34 81-88 https://glytoucan.org/Structures/Glycans/G54161DR denotes heparin
T35 100-107 https://glytoucan.org/Structures/Glycans/G00021MO denotes heparin
T36 100-107 https://glytoucan.org/Structures/Glycans/G54161DR denotes heparin
T37 140-147 https://glytoucan.org/Structures/Glycans/G00021MO denotes heparin
T38 140-147 https://glytoucan.org/Structures/Glycans/G54161DR denotes heparin

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T58 81-88 Body_part denotes heparin http://purl.org/sig/ont/fma/fma82839
T59 100-107 Body_part denotes heparin http://purl.org/sig/ont/fma/fma82839
T60 140-147 Body_part denotes heparin http://purl.org/sig/ont/fma/fma82839
T61 1158-1162 Body_part denotes limb http://purl.org/sig/ont/fma/fma7182

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T12 1158-1162 Body_part denotes limb http://purl.obolibrary.org/obo/UBERON_0002101

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T91 66-69 Disease denotes HIT http://purl.obolibrary.org/obo/MONDO_0018048
T92 525-528 Disease denotes HIT http://purl.obolibrary.org/obo/MONDO_0018048
T93 572-575 Disease denotes HIT http://purl.obolibrary.org/obo/MONDO_0018048
T94 653-663 Disease denotes thrombosis http://purl.obolibrary.org/obo/MONDO_0000831
T95 924-948 Disease denotes consumptive coagulopathy http://purl.obolibrary.org/obo/MONDO_0001243
T96 936-948 Disease denotes coagulopathy http://purl.obolibrary.org/obo/MONDO_0001531
T97 969-977 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T98 1088-1093 Disease denotes lupus http://purl.obolibrary.org/obo/MONDO_0004670
T99 1143-1153 Disease denotes thrombosis http://purl.obolibrary.org/obo/MONDO_0000831
T100 1263-1266 Disease denotes HIT http://purl.obolibrary.org/obo/MONDO_0018048

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T84 134-135 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T85 349-350 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T86 393-394 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T87 434-435 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T88 704-705 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T89 1055-1056 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T90 1158-1162 http://www.ebi.ac.uk/efo/EFO_0000876 denotes limb

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T41 81-88 Chemical denotes heparin http://purl.obolibrary.org/obo/CHEBI_28304
T42 100-107 Chemical denotes heparin http://purl.obolibrary.org/obo/CHEBI_28304
T43 140-147 Chemical denotes heparin http://purl.obolibrary.org/obo/CHEBI_28304
T44 148-161 Chemical denotes anticoagulant http://purl.obolibrary.org/obo/CHEBI_50249
T45 295-305 Chemical denotes argatroban http://purl.obolibrary.org/obo/CHEBI_48720
T46 307-318 Chemical denotes bivalirudin http://purl.obolibrary.org/obo/CHEBI_59173
T47 332-344 Chemical denotes fondaparinux http://purl.obolibrary.org/obo/CHEBI_61033
T48 363-376 Chemical denotes anticoagulant http://purl.obolibrary.org/obo/CHEBI_50249
T49 406-415 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T50 577-587 Chemical denotes argatroban http://purl.obolibrary.org/obo/CHEBI_48720
T51 725-735 Chemical denotes argatroban http://purl.obolibrary.org/obo/CHEBI_48720
T52 914-922 Chemical denotes warfarin http://purl.obolibrary.org/obo/CHEBI_10033
T53 1069-1078 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T54 1094-1107 Chemical denotes anticoagulant http://purl.obolibrary.org/obo/CHEBI_50249
T55 1201-1211 Chemical denotes argatroban http://purl.obolibrary.org/obo/CHEBI_48720

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T73 0-479 Sentence denotes The first step in the management of highly suspected or confirmed HIT is to stop heparin (including heparin flushes), and to initiate a non-heparin anticoagulant, to prevent thrombotic events, in the setting of ongoing massive thrombin generation.4 Available options for anticoagulation include argatroban, bivalirudin, danaparoid, fondaparinux, or a direct oral anticoagulant.6 Argatroban is a reversible inhibitor of thrombin5 with a short half-life and is not renally cleared.
T74 480-1168 Sentence denotes It is commonly used in the United States for HIT.4 In 2 multicenter trials of patients with HIT, argatroban resulted in reduced composite endpoint of death, amputation, and thrombosis, when compared with historic controls.5 A major concern with argatroban is potential under-anticoagulation in patients with elevated partial thromboplastin time, secondary to additional coagulopathies (hepatic dysfunction, prior anticoagulation with warfarin, consumptive coagulopathy, and more recently, COVID-19).4 Partial thromboplastin time confounding may also occur in the presence of a nonspecific inhibitor (such as lupus anticoagulant).8 This would increase the risk of thrombosis and limb loss.
T75 1169-1270 Sentence denotes Data supporting the efficacy of argatroban is limited to patients with suspected or confirmed HIT.8,9

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T65 66-69 Phenotype denotes HIT http://purl.obolibrary.org/obo/HP_0011874
T66 525-528 Phenotype denotes HIT http://purl.obolibrary.org/obo/HP_0011874
T67 572-575 Phenotype denotes HIT http://purl.obolibrary.org/obo/HP_0011874
T68 850-864 Phenotype denotes coagulopathies http://purl.obolibrary.org/obo/HP_0003256
T69 936-948 Phenotype denotes coagulopathy http://purl.obolibrary.org/obo/HP_0003256
T70 1088-1107 Phenotype denotes lupus anticoagulant http://purl.obolibrary.org/obo/HP_0025343
T71 1263-1266 Phenotype denotes HIT http://purl.obolibrary.org/obo/HP_0011874

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
347 227-235 Gene denotes thrombin Gene:2147
348 419-427 Gene denotes thrombin Gene:2147
349 558-566 Species denotes patients Tax:9606
350 774-782 Species denotes patients Tax:9606
351 1226-1234 Species denotes patients Tax:9606
352 81-88 Chemical denotes heparin MESH:D006493
353 100-107 Chemical denotes heparin MESH:D006493
354 140-147 Chemical denotes heparin MESH:D006493
355 295-305 Chemical denotes argatroban MESH:C031942
356 320-330 Chemical denotes danaparoid MESH:C035838
357 332-344 Chemical denotes fondaparinux MESH:D000077425
358 379-389 Chemical denotes Argatroban MESH:C031942
359 577-587 Chemical denotes argatroban MESH:C031942
360 725-735 Chemical denotes argatroban MESH:C031942
361 914-922 Chemical denotes warfarin MESH:D014859
362 1201-1211 Chemical denotes argatroban MESH:C031942
363 66-69 Disease denotes HIT MESH:D013921
364 174-184 Disease denotes thrombotic MESH:D013927
365 525-528 Disease denotes HIT MESH:D013921
366 572-575 Disease denotes HIT MESH:D013921
367 630-635 Disease denotes death MESH:D003643
368 653-663 Disease denotes thrombosis MESH:D013927
369 850-864 Disease denotes coagulopathies MESH:D001778
370 866-885 Disease denotes hepatic dysfunction MESH:D008107
371 924-948 Disease denotes consumptive coagulopathy MESH:D004211
372 969-977 Disease denotes COVID-19 MESH:C000657245
373 1143-1153 Disease denotes thrombosis MESH:D013927
374 1158-1167 Disease denotes limb loss MESH:D017880
375 1263-1266 Disease denotes HIT MESH:D013921

2_test

Id Subject Object Predicate Lexical cue
32720827-30482768-61488857 377-378 30482768 denotes 6
32720827-28416511-61488858 427-428 28416511 denotes 5
32720827-28416511-61488859 702-703 28416511 denotes 5
32720827-25590528-61488860 1109-1110 25590528 denotes 8
32720827-25590528-61488861 1267-1268 25590528 denotes 8
32720827-21264902-61488862 1269-1270 21264902 denotes 9