PMC:7388103 / 55-1442
Annnotations
LitCovid_Glycan-Motif-Structure
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T3 | 302-309 | https://glytoucan.org/Structures/Glycans/G00021MO | denotes | Heparin |
T4 | 302-309 | https://glytoucan.org/Structures/Glycans/G54161DR | denotes | Heparin |
T5 | 373-380 | https://glytoucan.org/Structures/Glycans/G00021MO | denotes | heparin |
T6 | 373-380 | https://glytoucan.org/Structures/Glycans/G54161DR | denotes | heparin |
T7 | 1101-1108 | https://glytoucan.org/Structures/Glycans/G00021MO | denotes | heparin |
T8 | 1101-1108 | https://glytoucan.org/Structures/Glycans/G54161DR | denotes | heparin |
T9 | 1119-1126 | https://glytoucan.org/Structures/Glycans/G00021MO | denotes | Heparin |
T10 | 1119-1126 | https://glytoucan.org/Structures/Glycans/G54161DR | denotes | Heparin |
LitCovid-PD-FMA-UBERON
Id | Subject | Object | Predicate | Lexical cue | fma_id |
---|---|---|---|---|---|
T2 | 302-309 | Body_part | denotes | Heparin | http://purl.org/sig/ont/fma/fma82839 |
T3 | 373-380 | Body_part | denotes | heparin | http://purl.org/sig/ont/fma/fma82839 |
T4 | 636-644 | Body_part | denotes | platelet | http://purl.org/sig/ont/fma/fma62851 |
T5 | 655-660 | Body_part | denotes | liver | http://purl.org/sig/ont/fma/fma7197 |
T6 | 958-966 | Body_part | denotes | platelet | http://purl.org/sig/ont/fma/fma62851 |
T7 | 1004-1009 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
T8 | 1101-1108 | Body_part | denotes | heparin | http://purl.org/sig/ont/fma/fma82839 |
T9 | 1109-1117 | Body_part | denotes | antibody | http://purl.org/sig/ont/fma/fma62871 |
T10 | 1119-1126 | Body_part | denotes | Heparin | http://purl.org/sig/ont/fma/fma82839 |
T11 | 1185-1194 | Body_part | denotes | serotonin | http://purl.org/sig/ont/fma/fma67245 |
LitCovid-PD-UBERON
Id | Subject | Object | Predicate | Lexical cue | uberon_id |
---|---|---|---|---|---|
T1 | 655-660 | Body_part | denotes | liver | http://purl.obolibrary.org/obo/UBERON_0002107 |
LitCovid-PD-MONDO
Id | Subject | Object | Predicate | Lexical cue | mondo_id |
---|---|---|---|---|---|
T4 | 0-8 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
T5 | 10-34 | Disease | denotes | coronavirus disease-2019 | http://purl.obolibrary.org/obo/MONDO_0100096 |
T6 | 36-45 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
T7 | 302-334 | Disease | denotes | Heparin-induced thrombocytopenia | http://purl.obolibrary.org/obo/MONDO_0018048 |
T8 | 318-334 | Disease | denotes | thrombocytopenia | http://purl.obolibrary.org/obo/MONDO_0002049 |
T9 | 336-339 | Disease | denotes | HIT | http://purl.obolibrary.org/obo/MONDO_0018048 |
T10 | 427-430 | Disease | denotes | HIT | http://purl.obolibrary.org/obo/MONDO_0018048 |
T11 | 449-457 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
T12 | 517-525 | Disease | denotes | diarrhea | http://purl.obolibrary.org/obo/MONDO_0001673 |
T13 | 560-568 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
T14 | 731-733 | Disease | denotes | he | http://purl.obolibrary.org/obo/MONDO_0017319 |
T15 | 760-782 | Disease | denotes | deep venous thrombosis | http://purl.obolibrary.org/obo/MONDO_0010432 |
T16 | 765-782 | Disease | denotes | venous thrombosis | http://purl.obolibrary.org/obo/MONDO_0008559 |
T17 | 772-782 | Disease | denotes | thrombosis | http://purl.obolibrary.org/obo/MONDO_0000831 |
T18 | 848-867 | Disease | denotes | respiratory failure | http://purl.obolibrary.org/obo/MONDO_0021113 |
T19 | 869-871 | Disease | denotes | he | http://purl.obolibrary.org/obo/MONDO_0017319 |
T20 | 1052-1055 | Disease | denotes | HIT | http://purl.obolibrary.org/obo/MONDO_0018048 |
T21 | 1272-1275 | Disease | denotes | HIT | http://purl.obolibrary.org/obo/MONDO_0018048 |
T22 | 1320-1323 | Disease | denotes | HIT | http://purl.obolibrary.org/obo/MONDO_0018048 |
T23 | 1327-1335 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
T24 | 1372-1375 | Disease | denotes | HIT | http://purl.obolibrary.org/obo/MONDO_0018048 |
LitCovid-PD-CLO
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 49-50 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T2 | 94-95 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T3 | 344-345 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T4 | 417-418 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T5 | 434-435 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T6 | 459-460 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | A |
T7 | 473-477 | http://purl.obolibrary.org/obo/UBERON_0003101 | denotes | male |
T8 | 473-477 | http://www.ebi.ac.uk/efo/EFO_0000970 | denotes | male |
T9 | 534-535 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T10 | 655-660 | http://purl.obolibrary.org/obo/UBERON_0002107 | denotes | liver |
T11 | 655-660 | http://www.ebi.ac.uk/efo/EFO_0000887 | denotes | liver |
T12 | 670-675 | http://purl.obolibrary.org/obo/UBERON_0000473 | denotes | tests |
T13 | 744-745 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T14 | 928-930 | http://purl.obolibrary.org/obo/CLO_0053733 | denotes | 11 |
T15 | 1004-1009 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
T16 | 1021-1022 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T17 | 1061-1062 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T18 | 1081-1082 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T19 | 1185-1194 | http://purl.obolibrary.org/obo/CHEBI_28790 | denotes | serotonin |
LitCovid-PD-CHEBI
Id | Subject | Object | Predicate | Lexical cue | chebi_id |
---|---|---|---|---|---|
T2 | 302-309 | Chemical | denotes | Heparin | http://purl.obolibrary.org/obo/CHEBI_28304 |
T3 | 373-380 | Chemical | denotes | heparin | http://purl.obolibrary.org/obo/CHEBI_28304 |
T4 | 473-477 | Chemical | denotes | male | http://purl.obolibrary.org/obo/CHEBI_30780 |
T5 | 1101-1108 | Chemical | denotes | heparin | http://purl.obolibrary.org/obo/CHEBI_28304 |
T6 | 1119-1126 | Chemical | denotes | Heparin | http://purl.obolibrary.org/obo/CHEBI_28304 |
T7 | 1169-1179 | Chemical | denotes | argatroban | http://purl.obolibrary.org/obo/CHEBI_48720 |
T8 | 1185-1194 | Chemical | denotes | serotonin | http://purl.obolibrary.org/obo/CHEBI_28790|http://purl.obolibrary.org/obo/CHEBI_350546 |
LitCovid-PD-GO-BP
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 117-128 | http://purl.obolibrary.org/obo/GO_0050817 | denotes | coagulation |
T2 | 577-590 | http://purl.obolibrary.org/obo/GO_0003968 | denotes | transcriptase |
T3 | 577-590 | http://purl.obolibrary.org/obo/GO_0003899 | denotes | transcriptase |
T4 | 1185-1202 | http://purl.obolibrary.org/obo/GO_0001820 | denotes | serotonin release |
LitCovid-sentences
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T3 | 0-137 | Sentence | denotes | COVID-19 (coronavirus disease-2019) infection is a highly prothrombotic state, resulting from a dysregulation of the coagulation cascade. |
T4 | 138-301 | Sentence | denotes | Therefore, thromboprophylaxis is strongly recommended in these patients, with some experts even advocating for therapeutic dosing to prevent thromboembolic events. |
T5 | 302-389 | Sentence | denotes | Heparin-induced thrombocytopenia (HIT) is a well-known complication of heparin therapy. |
T6 | 390-458 | Sentence | denotes | In this article, we report a case of HIT in a patient with COVID-19. |
T7 | 459-526 | Sentence | denotes | A 63-year-old male presented with 1 week of dry cough and diarrhea. |
T8 | 527-617 | Sentence | denotes | He had a positive nasopharyngeal COVID-19 reverse-transcriptase–polymerase chain reaction. |
T9 | 618-702 | Sentence | denotes | On admission, the platelet count and liver function tests were within normal limits. |
T10 | 703-830 | Sentence | denotes | During his hospitalization, he developed a right femoral deep venous thrombosis and was started on therapeutic anticoagulation. |
T11 | 831-914 | Sentence | denotes | Due to worsening respiratory failure, he was intubated and mechanically ventilated. |
T12 | 915-1013 | Sentence | denotes | Between days 11 and 12 of hospitalization, platelet count dropped from 304 000 to 96 000 cells/µL. |
T13 | 1014-1118 | Sentence | denotes | He had a high pretest probability for HIT with a 4T score of 6 and a positive anti-PF4/heparin antibody. |
T14 | 1119-1180 | Sentence | denotes | Heparin drip was discontinued and was switched to argatroban. |
T15 | 1181-1276 | Sentence | denotes | The serotonin release assay eventually returned positive, which confirmed the diagnosis of HIT. |
T16 | 1277-1387 | Sentence | denotes | We also discuss potential overdiagnosis of HIT in COVID-19 through 4 cases with false-positive HIT antibodies. |
LitCovid-PD-HP
Id | Subject | Object | Predicate | Lexical cue | hp_id |
---|---|---|---|---|---|
T2 | 279-300 | Phenotype | denotes | thromboembolic events | http://purl.obolibrary.org/obo/HP_0001907 |
T3 | 302-334 | Phenotype | denotes | Heparin-induced thrombocytopenia | http://purl.obolibrary.org/obo/HP_0011874 |
T4 | 336-339 | Phenotype | denotes | HIT | http://purl.obolibrary.org/obo/HP_0011874 |
T5 | 427-430 | Phenotype | denotes | HIT | http://purl.obolibrary.org/obo/HP_0011874 |
T6 | 503-512 | Phenotype | denotes | dry cough | http://purl.obolibrary.org/obo/HP_0031246 |
T7 | 517-525 | Phenotype | denotes | diarrhea | http://purl.obolibrary.org/obo/HP_0002014 |
T8 | 760-782 | Phenotype | denotes | deep venous thrombosis | http://purl.obolibrary.org/obo/HP_0002625 |
T9 | 848-867 | Phenotype | denotes | respiratory failure | http://purl.obolibrary.org/obo/HP_0002878 |
T10 | 1052-1055 | Phenotype | denotes | HIT | http://purl.obolibrary.org/obo/HP_0011874 |
T11 | 1272-1275 | Phenotype | denotes | HIT | http://purl.obolibrary.org/obo/HP_0011874 |
T12 | 1320-1323 | Phenotype | denotes | HIT | http://purl.obolibrary.org/obo/HP_0011874 |
T13 | 1372-1375 | Phenotype | denotes | HIT | http://purl.obolibrary.org/obo/HP_0011874 |
LitCovid-PubTator
Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
---|---|---|---|---|---|
31 | 1097-1100 | Gene | denotes | PF4 | Gene:5196 |
32 | 201-209 | Species | denotes | patients | Tax:9606 |
33 | 436-443 | Species | denotes | patient | Tax:9606 |
34 | 302-309 | Chemical | denotes | Heparin | MESH:D006493 |
35 | 373-380 | Chemical | denotes | heparin | MESH:D006493 |
36 | 1101-1108 | Chemical | denotes | heparin | MESH:D006493 |
37 | 1119-1126 | Chemical | denotes | Heparin | MESH:D006493 |
38 | 1169-1179 | Chemical | denotes | argatroban | MESH:C031942 |
39 | 1185-1194 | Chemical | denotes | serotonin | MESH:D012701 |
40 | 9-45 | Disease | denotes | (coronavirus disease-2019) infection | MESH:C000657245 |
41 | 279-293 | Disease | denotes | thromboembolic | MESH:D013923 |
42 | 318-334 | Disease | denotes | thrombocytopenia | MESH:D013921 |
43 | 336-339 | Disease | denotes | HIT | MESH:D013921 |
44 | 427-430 | Disease | denotes | HIT | MESH:D013921 |
45 | 449-457 | Disease | denotes | COVID-19 | MESH:C000657245 |
46 | 503-512 | Disease | denotes | dry cough | MESH:D003371 |
47 | 517-525 | Disease | denotes | diarrhea | MESH:D003967 |
48 | 560-568 | Disease | denotes | COVID-19 | MESH:C000657245 |
49 | 752-782 | Disease | denotes | femoral deep venous thrombosis | MESH:D020246 |
50 | 848-867 | Disease | denotes | respiratory failure | MESH:D012131 |
51 | 1052-1055 | Disease | denotes | HIT | MESH:D013921 |
52 | 1272-1275 | Disease | denotes | HIT | MESH:D013921 |
53 | 1320-1323 | Disease | denotes | HIT | MESH:D013921 |
54 | 1327-1335 | Disease | denotes | COVID-19 | MESH:C000657245 |
55 | 1372-1375 | Disease | denotes | HIT | MESH:D013921 |