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PMC:7388103 / 55-1442 JSONTXT

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LitCovid_Glycan-Motif-Structure

Id Subject Object Predicate Lexical cue
T3 302-309 https://glytoucan.org/Structures/Glycans/G00021MO denotes Heparin
T4 302-309 https://glytoucan.org/Structures/Glycans/G54161DR denotes Heparin
T5 373-380 https://glytoucan.org/Structures/Glycans/G00021MO denotes heparin
T6 373-380 https://glytoucan.org/Structures/Glycans/G54161DR denotes heparin
T7 1101-1108 https://glytoucan.org/Structures/Glycans/G00021MO denotes heparin
T8 1101-1108 https://glytoucan.org/Structures/Glycans/G54161DR denotes heparin
T9 1119-1126 https://glytoucan.org/Structures/Glycans/G00021MO denotes Heparin
T10 1119-1126 https://glytoucan.org/Structures/Glycans/G54161DR denotes Heparin

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T2 302-309 Body_part denotes Heparin http://purl.org/sig/ont/fma/fma82839
T3 373-380 Body_part denotes heparin http://purl.org/sig/ont/fma/fma82839
T4 636-644 Body_part denotes platelet http://purl.org/sig/ont/fma/fma62851
T5 655-660 Body_part denotes liver http://purl.org/sig/ont/fma/fma7197
T6 958-966 Body_part denotes platelet http://purl.org/sig/ont/fma/fma62851
T7 1004-1009 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T8 1101-1108 Body_part denotes heparin http://purl.org/sig/ont/fma/fma82839
T9 1109-1117 Body_part denotes antibody http://purl.org/sig/ont/fma/fma62871
T10 1119-1126 Body_part denotes Heparin http://purl.org/sig/ont/fma/fma82839
T11 1185-1194 Body_part denotes serotonin http://purl.org/sig/ont/fma/fma67245

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 655-660 Body_part denotes liver http://purl.obolibrary.org/obo/UBERON_0002107

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T4 0-8 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T5 10-34 Disease denotes coronavirus disease-2019 http://purl.obolibrary.org/obo/MONDO_0100096
T6 36-45 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T7 302-334 Disease denotes Heparin-induced thrombocytopenia http://purl.obolibrary.org/obo/MONDO_0018048
T8 318-334 Disease denotes thrombocytopenia http://purl.obolibrary.org/obo/MONDO_0002049
T9 336-339 Disease denotes HIT http://purl.obolibrary.org/obo/MONDO_0018048
T10 427-430 Disease denotes HIT http://purl.obolibrary.org/obo/MONDO_0018048
T11 449-457 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T12 517-525 Disease denotes diarrhea http://purl.obolibrary.org/obo/MONDO_0001673
T13 560-568 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T14 731-733 Disease denotes he http://purl.obolibrary.org/obo/MONDO_0017319
T15 760-782 Disease denotes deep venous thrombosis http://purl.obolibrary.org/obo/MONDO_0010432
T16 765-782 Disease denotes venous thrombosis http://purl.obolibrary.org/obo/MONDO_0008559
T17 772-782 Disease denotes thrombosis http://purl.obolibrary.org/obo/MONDO_0000831
T18 848-867 Disease denotes respiratory failure http://purl.obolibrary.org/obo/MONDO_0021113
T19 869-871 Disease denotes he http://purl.obolibrary.org/obo/MONDO_0017319
T20 1052-1055 Disease denotes HIT http://purl.obolibrary.org/obo/MONDO_0018048
T21 1272-1275 Disease denotes HIT http://purl.obolibrary.org/obo/MONDO_0018048
T22 1320-1323 Disease denotes HIT http://purl.obolibrary.org/obo/MONDO_0018048
T23 1327-1335 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T24 1372-1375 Disease denotes HIT http://purl.obolibrary.org/obo/MONDO_0018048

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T1 49-50 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T2 94-95 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T3 344-345 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T4 417-418 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T5 434-435 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T6 459-460 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T7 473-477 http://purl.obolibrary.org/obo/UBERON_0003101 denotes male
T8 473-477 http://www.ebi.ac.uk/efo/EFO_0000970 denotes male
T9 534-535 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T10 655-660 http://purl.obolibrary.org/obo/UBERON_0002107 denotes liver
T11 655-660 http://www.ebi.ac.uk/efo/EFO_0000887 denotes liver
T12 670-675 http://purl.obolibrary.org/obo/UBERON_0000473 denotes tests
T13 744-745 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T14 928-930 http://purl.obolibrary.org/obo/CLO_0053733 denotes 11
T15 1004-1009 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T16 1021-1022 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T17 1061-1062 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T18 1081-1082 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T19 1185-1194 http://purl.obolibrary.org/obo/CHEBI_28790 denotes serotonin

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T2 302-309 Chemical denotes Heparin http://purl.obolibrary.org/obo/CHEBI_28304
T3 373-380 Chemical denotes heparin http://purl.obolibrary.org/obo/CHEBI_28304
T4 473-477 Chemical denotes male http://purl.obolibrary.org/obo/CHEBI_30780
T5 1101-1108 Chemical denotes heparin http://purl.obolibrary.org/obo/CHEBI_28304
T6 1119-1126 Chemical denotes Heparin http://purl.obolibrary.org/obo/CHEBI_28304
T7 1169-1179 Chemical denotes argatroban http://purl.obolibrary.org/obo/CHEBI_48720
T8 1185-1194 Chemical denotes serotonin http://purl.obolibrary.org/obo/CHEBI_28790|http://purl.obolibrary.org/obo/CHEBI_350546

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T1 117-128 http://purl.obolibrary.org/obo/GO_0050817 denotes coagulation
T2 577-590 http://purl.obolibrary.org/obo/GO_0003968 denotes transcriptase
T3 577-590 http://purl.obolibrary.org/obo/GO_0003899 denotes transcriptase
T4 1185-1202 http://purl.obolibrary.org/obo/GO_0001820 denotes serotonin release

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T3 0-137 Sentence denotes COVID-19 (coronavirus disease-2019) infection is a highly prothrombotic state, resulting from a dysregulation of the coagulation cascade.
T4 138-301 Sentence denotes Therefore, thromboprophylaxis is strongly recommended in these patients, with some experts even advocating for therapeutic dosing to prevent thromboembolic events.
T5 302-389 Sentence denotes Heparin-induced thrombocytopenia (HIT) is a well-known complication of heparin therapy.
T6 390-458 Sentence denotes In this article, we report a case of HIT in a patient with COVID-19.
T7 459-526 Sentence denotes A 63-year-old male presented with 1 week of dry cough and diarrhea.
T8 527-617 Sentence denotes He had a positive nasopharyngeal COVID-19 reverse-transcriptase–polymerase chain reaction.
T9 618-702 Sentence denotes On admission, the platelet count and liver function tests were within normal limits.
T10 703-830 Sentence denotes During his hospitalization, he developed a right femoral deep venous thrombosis and was started on therapeutic anticoagulation.
T11 831-914 Sentence denotes Due to worsening respiratory failure, he was intubated and mechanically ventilated.
T12 915-1013 Sentence denotes Between days 11 and 12 of hospitalization, platelet count dropped from 304 000 to 96 000 cells/µL.
T13 1014-1118 Sentence denotes He had a high pretest probability for HIT with a 4T score of 6 and a positive anti-PF4/heparin antibody.
T14 1119-1180 Sentence denotes Heparin drip was discontinued and was switched to argatroban.
T15 1181-1276 Sentence denotes The serotonin release assay eventually returned positive, which confirmed the diagnosis of HIT.
T16 1277-1387 Sentence denotes We also discuss potential overdiagnosis of HIT in COVID-19 through 4 cases with false-positive HIT antibodies.

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T2 279-300 Phenotype denotes thromboembolic events http://purl.obolibrary.org/obo/HP_0001907
T3 302-334 Phenotype denotes Heparin-induced thrombocytopenia http://purl.obolibrary.org/obo/HP_0011874
T4 336-339 Phenotype denotes HIT http://purl.obolibrary.org/obo/HP_0011874
T5 427-430 Phenotype denotes HIT http://purl.obolibrary.org/obo/HP_0011874
T6 503-512 Phenotype denotes dry cough http://purl.obolibrary.org/obo/HP_0031246
T7 517-525 Phenotype denotes diarrhea http://purl.obolibrary.org/obo/HP_0002014
T8 760-782 Phenotype denotes deep venous thrombosis http://purl.obolibrary.org/obo/HP_0002625
T9 848-867 Phenotype denotes respiratory failure http://purl.obolibrary.org/obo/HP_0002878
T10 1052-1055 Phenotype denotes HIT http://purl.obolibrary.org/obo/HP_0011874
T11 1272-1275 Phenotype denotes HIT http://purl.obolibrary.org/obo/HP_0011874
T12 1320-1323 Phenotype denotes HIT http://purl.obolibrary.org/obo/HP_0011874
T13 1372-1375 Phenotype denotes HIT http://purl.obolibrary.org/obo/HP_0011874

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
31 1097-1100 Gene denotes PF4 Gene:5196
32 201-209 Species denotes patients Tax:9606
33 436-443 Species denotes patient Tax:9606
34 302-309 Chemical denotes Heparin MESH:D006493
35 373-380 Chemical denotes heparin MESH:D006493
36 1101-1108 Chemical denotes heparin MESH:D006493
37 1119-1126 Chemical denotes Heparin MESH:D006493
38 1169-1179 Chemical denotes argatroban MESH:C031942
39 1185-1194 Chemical denotes serotonin MESH:D012701
40 9-45 Disease denotes (coronavirus disease-2019) infection MESH:C000657245
41 279-293 Disease denotes thromboembolic MESH:D013923
42 318-334 Disease denotes thrombocytopenia MESH:D013921
43 336-339 Disease denotes HIT MESH:D013921
44 427-430 Disease denotes HIT MESH:D013921
45 449-457 Disease denotes COVID-19 MESH:C000657245
46 503-512 Disease denotes dry cough MESH:D003371
47 517-525 Disease denotes diarrhea MESH:D003967
48 560-568 Disease denotes COVID-19 MESH:C000657245
49 752-782 Disease denotes femoral deep venous thrombosis MESH:D020246
50 848-867 Disease denotes respiratory failure MESH:D012131
51 1052-1055 Disease denotes HIT MESH:D013921
52 1272-1275 Disease denotes HIT MESH:D013921
53 1320-1323 Disease denotes HIT MESH:D013921
54 1327-1335 Disease denotes COVID-19 MESH:C000657245
55 1372-1375 Disease denotes HIT MESH:D013921