PMC:7388103 / 4585-6498
Annnotations
LitCovid_Glycan-Motif-Structure
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T23 | 1286-1293 | https://glytoucan.org/Structures/Glycans/G00021MO | denotes | heparin |
| T24 | 1286-1293 | https://glytoucan.org/Structures/Glycans/G54161DR | denotes | heparin |
| T25 | 1804-1811 | https://glytoucan.org/Structures/Glycans/G00021MO | denotes | heparin |
| T26 | 1804-1811 | https://glytoucan.org/Structures/Glycans/G54161DR | denotes | heparin |
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T33 | 286-294 | Body_part | denotes | platelet | http://purl.org/sig/ont/fma/fma62851 |
| T34 | 310-318 | Body_part | denotes | antibody | http://purl.org/sig/ont/fma/fma62871 |
| T35 | 611-615 | Body_part | denotes | vein | http://purl.org/sig/ont/fma/fma50723 |
| T36 | 944-952 | Body_part | denotes | Antibody | http://purl.org/sig/ont/fma/fma62871 |
| T37 | 1286-1293 | Body_part | denotes | heparin | http://purl.org/sig/ont/fma/fma82839 |
| T38 | 1305-1314 | Body_part | denotes | platelets | http://purl.org/sig/ont/fma/fma62851 |
| T39 | 1359-1367 | Body_part | denotes | antibody | http://purl.org/sig/ont/fma/fma62871 |
| T40 | 1476-1485 | Body_part | denotes | Serotonin | http://purl.org/sig/ont/fma/fma67245 |
| T41 | 1630-1634 | Body_part | denotes | vein | http://purl.org/sig/ont/fma/fma50723 |
| T42 | 1676-1684 | Body_part | denotes | platelet | http://purl.org/sig/ont/fma/fma62851 |
| T43 | 1804-1811 | Body_part | denotes | heparin | http://purl.org/sig/ont/fma/fma82839 |
| T44 | 1904-1912 | Body_part | denotes | antibody | http://purl.org/sig/ont/fma/fma62871 |
LitCovid-PD-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T8 | 606-615 | Body_part | denotes | deep vein | http://purl.obolibrary.org/obo/UBERON_0035552 |
| T9 | 611-615 | Body_part | denotes | vein | http://purl.obolibrary.org/obo/UBERON_0001638 |
| T10 | 1625-1634 | Body_part | denotes | deep vein | http://purl.obolibrary.org/obo/UBERON_0035552 |
| T11 | 1630-1634 | Body_part | denotes | vein | http://purl.obolibrary.org/obo/UBERON_0001638 |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T54 | 39-42 | Disease | denotes | HIT | http://purl.obolibrary.org/obo/MONDO_0018048 |
| T55 | 120-155 | Disease | denotes | acute respiratory distress syndrome | http://purl.obolibrary.org/obo/MONDO_0006502 |
| T56 | 126-155 | Disease | denotes | respiratory distress syndrome | http://purl.obolibrary.org/obo/MONDO_0009971 |
| T57 | 169-177 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T58 | 178-187 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
| T59 | 193-209 | Disease | denotes | thrombocytopenia | http://purl.obolibrary.org/obo/MONDO_0002049 |
| T60 | 263-266 | Disease | denotes | HIT | http://purl.obolibrary.org/obo/MONDO_0018048 |
| T61 | 384-386 | Disease | denotes | OD | http://purl.obolibrary.org/obo/MONDO_0017178 |
| T62 | 563-566 | Disease | denotes | HIT | http://purl.obolibrary.org/obo/MONDO_0018048 |
| T63 | 616-626 | Disease | denotes | thrombosis | http://purl.obolibrary.org/obo/MONDO_0000831 |
| T64 | 651-669 | Disease | denotes | pulmonary embolism | http://purl.obolibrary.org/obo/MONDO_0005279 |
| T65 | 717-727 | Disease | denotes | Thrombosis | http://purl.obolibrary.org/obo/MONDO_0000831 |
| T66 | 757-801 | Disease | denotes | disseminated intravascular coagulation (DIC) | http://purl.obolibrary.org/obo/MONDO_0001243 |
| T67 | 1134-1157 | Disease | denotes | Acute coronary syndrome | http://purl.obolibrary.org/obo/MONDO_0005542 |
| T68 | 1162-1181 | Disease | denotes | atrial fibrillation | http://purl.obolibrary.org/obo/MONDO_0004981 |
| T69 | 1216-1226 | Disease | denotes | thrombosis | http://purl.obolibrary.org/obo/MONDO_0000831 |
| T70 | 1635-1645 | Disease | denotes | thrombosis | http://purl.obolibrary.org/obo/MONDO_0000831 |
| T71 | 1651-1669 | Disease | denotes | pulmonary embolism | http://purl.obolibrary.org/obo/MONDO_0005279 |
| T72 | 1695-1738 | Disease | denotes | DIC, disseminated intravascular coagulation | http://purl.obolibrary.org/obo/MONDO_0001243 |
| T73 | 1771-1781 | Disease | denotes | Thrombosis | http://purl.obolibrary.org/obo/MONDO_0000831 |
| T74 | 1799-1802 | Disease | denotes | HIT | http://purl.obolibrary.org/obo/MONDO_0018048 |
| T75 | 1804-1836 | Disease | denotes | heparin-induced thrombocytopenia | http://purl.obolibrary.org/obo/MONDO_0018048 |
| T76 | 1820-1836 | Disease | denotes | thrombocytopenia | http://purl.obolibrary.org/obo/MONDO_0002049 |
| T77 | 1860-1863 | Disease | denotes | HIT | http://purl.obolibrary.org/obo/MONDO_0018048 |
| T78 | 1900-1903 | Disease | denotes | HIT | http://purl.obolibrary.org/obo/MONDO_0018048 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T56 | 105-106 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T57 | 275-276 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T58 | 594-595 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T59 | 611-615 | http://purl.obolibrary.org/obo/UBERON_0001638 | denotes | vein |
| T60 | 611-615 | http://www.ebi.ac.uk/efo/EFO_0000816 | denotes | vein |
| T61 | 920-926 | http://purl.obolibrary.org/obo/UBERON_0000473 | denotes | Tested |
| T62 | 1064-1068 | http://purl.obolibrary.org/obo/UBERON_0003101 | denotes | Male |
| T63 | 1064-1068 | http://www.ebi.ac.uk/efo/EFO_0000970 | denotes | Male |
| T64 | 1070-1074 | http://purl.obolibrary.org/obo/UBERON_0003101 | denotes | Male |
| T65 | 1070-1074 | http://www.ebi.ac.uk/efo/EFO_0000970 | denotes | Male |
| T66 | 1076-1080 | http://purl.obolibrary.org/obo/UBERON_0003101 | denotes | Male |
| T67 | 1076-1080 | http://www.ebi.ac.uk/efo/EFO_0000970 | denotes | Male |
| T68 | 1082-1088 | http://purl.obolibrary.org/obo/UBERON_0003100 | denotes | Female |
| T69 | 1090-1096 | http://purl.obolibrary.org/obo/UBERON_0003100 | denotes | Female |
| T70 | 1316-1318 | http://purl.obolibrary.org/obo/CLO_0053733 | denotes | 11 |
| T71 | 1476-1485 | http://purl.obolibrary.org/obo/CHEBI_28790 | denotes | Serotonin |
| T72 | 1630-1634 | http://purl.obolibrary.org/obo/UBERON_0001638 | denotes | vein |
| T73 | 1630-1634 | http://www.ebi.ac.uk/efo/EFO_0000816 | denotes | vein |
| T74 | 1838-1839 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T22 | 344-354 | Chemical | denotes | argatroban | http://purl.obolibrary.org/obo/CHEBI_48720 |
| T23 | 797-800 | Chemical | denotes | DIC | http://purl.obolibrary.org/obo/CHEBI_4305|http://purl.obolibrary.org/obo/CHEBI_53092 |
| T25 | 1203-1205 | Chemical | denotes | PE | http://purl.obolibrary.org/obo/CHEBI_16038|http://purl.obolibrary.org/obo/CHEBI_17553|http://purl.obolibrary.org/obo/CHEBI_74762 |
| T28 | 1286-1293 | Chemical | denotes | heparin | http://purl.obolibrary.org/obo/CHEBI_28304 |
| T29 | 1476-1485 | Chemical | denotes | Serotonin | http://purl.obolibrary.org/obo/CHEBI_28790 |
| T30 | 1562-1565 | Chemical | denotes | DIC | http://purl.obolibrary.org/obo/CHEBI_4305|http://purl.obolibrary.org/obo/CHEBI_53092 |
| T32 | 1647-1649 | Chemical | denotes | PE | http://purl.obolibrary.org/obo/CHEBI_16038|http://purl.obolibrary.org/obo/CHEBI_17553|http://purl.obolibrary.org/obo/CHEBI_74762 |
| T35 | 1695-1698 | Chemical | denotes | DIC | http://purl.obolibrary.org/obo/CHEBI_4305|http://purl.obolibrary.org/obo/CHEBI_53092 |
| T37 | 1804-1811 | Chemical | denotes | heparin | http://purl.obolibrary.org/obo/CHEBI_28304 |
LitCovid-PD-GO-BP
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T9 | 784-795 | http://purl.obolibrary.org/obo/GO_0050817 | denotes | coagulation |
| T10 | 1476-1493 | http://purl.obolibrary.org/obo/GO_0001820 | denotes | Serotonin release |
| T11 | 1727-1738 | http://purl.obolibrary.org/obo/GO_0050817 | denotes | coagulation |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T44 | 0-42 | Sentence | denotes | Other Patients With COVID and Possible HIT |
| T45 | 43-267 | Sentence | denotes | We encountered 4 additional patients admitted to our ICU with a diagnosis of acute respiratory distress syndrome secondary to COVID-19 infection with thrombocytopenia, and an intermediate to high pretest probability for HIT. |
| T46 | 268-415 | Sentence | denotes | Due to a positive platelet factor 4 (PF4) antibody, they were started on an argatroban, pending send out results of OD levels and functional assay. |
| T47 | 416-446 | Sentence | denotes | However, the SRA was negative. |
| T48 | 447-567 | Sentence | denotes | Interestingly, their clinical characteristics (reported in Table 1) were similar to those of our patients with true HIT. |
| T49 | 568-670 | Sentence | denotes | Two of these patients had a confirmed deep vein thrombosis, and one with suspected pulmonary embolism. |
| T50 | 671-802 | Sentence | denotes | Also, 2 patients met International Society on Thrombosis and Haemostasis criteria for disseminated intravascular coagulation (DIC). |
| T51 | 803-877 | Sentence | denotes | All the patients were in hypotensive shock, requiring vasopressor support. |
| T52 | 878-886 | Sentence | denotes | Table 1. |
| T53 | 888-953 | Sentence | denotes | Characteristics of Patients Who Tested Positive for PF4 Antibody. |
| T54 | 954-1025 | Sentence | denotes | Characteristics Patient 1a Patient 2 Patient 3 Patient 4 Patient 5 |
| T55 | 1026-1058 | Sentence | denotes | Age in years 63 53 63 70 46 |
| T56 | 1059-1096 | Sentence | denotes | Sex Male Male Male Female Female |
| T57 | 1097-1205 | Sentence | denotes | Indication for anticoagulation DVT Acute coronary syndrome and atrial fibrillation DVT DVT Suspected PE |
| T58 | 1206-1261 | Sentence | denotes | Confirmed thrombosis via imaging Yes No Yes Yes No |
| T59 | 1262-1330 | Sentence | denotes | Days from initiation of heparin to drop in platelets 11 7 6 8 2 |
| T60 | 1331-1354 | Sentence | denotes | 4T score 6 5 7 7 4 |
| T61 | 1355-1475 | Sentence | denotes | PF4 antibody (optical density) Positive (1.243) Positive (0.707) Positive (0.767) Positive (0.042) Positive (0.307) |
| T62 | 1476-1549 | Sentence | denotes | Serotonin release assay Positive Negative Negative Negative Negative |
| T63 | 1550-1604 | Sentence | denotes | Presence of DIC by ISTH criteria No No No Yes Yes |
| T64 | 1605-1837 | Sentence | denotes | Abbreviations: DVT, deep vein thrombosis; PE, pulmonary embolism; PF4, platelet factor 4; DIC, disseminated intravascular coagulation; ISTH, International Society on Thrombosis and Haemostasis; HIT, heparin-induced thrombocytopenia. |
| T65 | 1838-1864 | Sentence | denotes | a Patient 1 had true HIT. |
| T66 | 1865-1913 | Sentence | denotes | Patients 2 to 5 had false-positive HIT antibody. |
LitCovid-PD-HP
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T33 | 39-42 | Phenotype | denotes | HIT | http://purl.obolibrary.org/obo/HP_0011874 |
| T34 | 126-146 | Phenotype | denotes | respiratory distress | http://purl.obolibrary.org/obo/HP_0002098 |
| T35 | 193-209 | Phenotype | denotes | thrombocytopenia | http://purl.obolibrary.org/obo/HP_0001873 |
| T36 | 263-266 | Phenotype | denotes | HIT | http://purl.obolibrary.org/obo/HP_0011874 |
| T37 | 563-566 | Phenotype | denotes | HIT | http://purl.obolibrary.org/obo/HP_0011874 |
| T38 | 606-626 | Phenotype | denotes | deep vein thrombosis | http://purl.obolibrary.org/obo/HP_0002625 |
| T39 | 651-669 | Phenotype | denotes | pulmonary embolism | http://purl.obolibrary.org/obo/HP_0002204 |
| T40 | 757-795 | Phenotype | denotes | disseminated intravascular coagulation | http://purl.obolibrary.org/obo/HP_0005521 |
| T41 | 797-800 | Phenotype | denotes | DIC | http://purl.obolibrary.org/obo/HP_0005521 |
| T42 | 840-845 | Phenotype | denotes | shock | http://purl.obolibrary.org/obo/HP_0031273 |
| T43 | 1162-1181 | Phenotype | denotes | atrial fibrillation | http://purl.obolibrary.org/obo/HP_0005110 |
| T44 | 1562-1565 | Phenotype | denotes | DIC | http://purl.obolibrary.org/obo/HP_0005521 |
| T45 | 1625-1645 | Phenotype | denotes | deep vein thrombosis | http://purl.obolibrary.org/obo/HP_0002625 |
| T46 | 1651-1669 | Phenotype | denotes | pulmonary embolism | http://purl.obolibrary.org/obo/HP_0002204 |
| T47 | 1695-1698 | Phenotype | denotes | DIC | http://purl.obolibrary.org/obo/HP_0005521 |
| T48 | 1700-1738 | Phenotype | denotes | disseminated intravascular coagulation | http://purl.obolibrary.org/obo/HP_0005521 |
| T49 | 1799-1802 | Phenotype | denotes | HIT | http://purl.obolibrary.org/obo/HP_0011874 |
| T50 | 1804-1836 | Phenotype | denotes | heparin-induced thrombocytopenia | http://purl.obolibrary.org/obo/HP_0011874 |
| T51 | 1860-1863 | Phenotype | denotes | HIT | http://purl.obolibrary.org/obo/HP_0011874 |
| T52 | 1900-1903 | Phenotype | denotes | HIT | http://purl.obolibrary.org/obo/HP_0011874 |
LitCovid-PubTator
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
|---|---|---|---|---|---|
| 167 | 6-14 | Species | denotes | Patients | Tax:9606 |
| 168 | 20-25 | Disease | denotes | COVID | MESH:C000657245 |
| 169 | 39-42 | Disease | denotes | HIT | MESH:D013921 |
| 190 | 305-308 | Gene | denotes | PF4 | Gene:5196 |
| 191 | 71-79 | Species | denotes | patients | Tax:9606 |
| 192 | 544-552 | Species | denotes | patients | Tax:9606 |
| 193 | 581-589 | Species | denotes | patients | Tax:9606 |
| 194 | 679-687 | Species | denotes | patients | Tax:9606 |
| 195 | 811-819 | Species | denotes | patients | Tax:9606 |
| 196 | 344-354 | Chemical | denotes | argatroban | MESH:C031942 |
| 197 | 429-432 | Chemical | denotes | SRA | |
| 198 | 120-155 | Disease | denotes | acute respiratory distress syndrome | MESH:D012128 |
| 199 | 169-177 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 200 | 178-187 | Disease | denotes | infection | MESH:D007239 |
| 201 | 193-209 | Disease | denotes | thrombocytopenia | MESH:D013921 |
| 202 | 263-266 | Disease | denotes | HIT | MESH:D013921 |
| 203 | 563-566 | Disease | denotes | HIT | MESH:D013921 |
| 204 | 606-626 | Disease | denotes | deep vein thrombosis | MESH:D020246 |
| 205 | 651-669 | Disease | denotes | pulmonary embolism | MESH:D011655 |
| 206 | 717-727 | Disease | denotes | Thrombosis | MESH:D013927 |
| 207 | 757-795 | Disease | denotes | disseminated intravascular coagulation | MESH:D004211 |
| 208 | 797-800 | Disease | denotes | DIC | MESH:D004211 |
| 209 | 828-845 | Disease | denotes | hypotensive shock | MESH:D007022 |
| 222 | 1355-1358 | Gene | denotes | PF4 | Gene:5196 |
| 223 | 971-978 | Species | denotes | Patient | Tax:9606 |
| 224 | 983-990 | Species | denotes | Patient | Tax:9606 |
| 225 | 994-1001 | Species | denotes | Patient | Tax:9606 |
| 226 | 1005-1012 | Species | denotes | Patient | Tax:9606 |
| 227 | 1016-1023 | Species | denotes | Patient | Tax:9606 |
| 228 | 1286-1293 | Chemical | denotes | heparin | MESH:D006493 |
| 229 | 1476-1485 | Chemical | denotes | Serotonin | MESH:D012701 |
| 230 | 1129-1157 | Disease | denotes | DVT Acute coronary syndrome | MESH:D054058 |
| 231 | 1162-1191 | Disease | denotes | atrial fibrillation DVT DVT | OMIM:612862 |
| 232 | 1216-1226 | Disease | denotes | thrombosis | MESH:D013927 |
| 233 | 1562-1565 | Disease | denotes | DIC | MESH:D004211 |
| 236 | 940-943 | Gene | denotes | PF4 | Gene:5196 |
| 237 | 907-915 | Species | denotes | Patients | Tax:9606 |
| 247 | 1671-1674 | Gene | denotes | PF4 | Gene:5196 |
| 248 | 1804-1811 | Chemical | denotes | heparin | MESH:D006493 |
| 249 | 1625-1645 | Disease | denotes | deep vein thrombosis | MESH:D020246 |
| 250 | 1651-1669 | Disease | denotes | pulmonary embolism | MESH:D011655 |
| 251 | 1695-1698 | Disease | denotes | DIC | MESH:D004211 |
| 252 | 1700-1738 | Disease | denotes | disseminated intravascular coagulation | MESH:D004211 |
| 253 | 1771-1781 | Disease | denotes | Thrombosis | MESH:D013927 |
| 254 | 1799-1802 | Disease | denotes | HIT | MESH:D013921 |
| 255 | 1820-1836 | Disease | denotes | thrombocytopenia | MESH:D013921 |
| 260 | 1841-1848 | Species | denotes | Patient | Tax:9606 |
| 261 | 1865-1873 | Species | denotes | Patients | Tax:9606 |
| 262 | 1860-1863 | Disease | denotes | HIT | MESH:D013921 |
| 263 | 1900-1903 | Disease | denotes | HIT | MESH:D013921 |