PMC:7388103 / 3916-4583 JSONTXT

{"project":"LitCovid_Glycan-Motif-Structure","denotations":[{"id":"T19","span":{"begin":194,"end":201},"obj":"https://glytoucan.org/Structures/Glycans/G00021MO"},{"id":"T20","span":{"begin":194,"end":201},"obj":"https://glytoucan.org/Structures/Glycans/G54161DR"},{"id":"T21","span":{"begin":329,"end":336},"obj":"https://glytoucan.org/Structures/Glycans/G00021MO"},{"id":"T22","span":{"begin":329,"end":336},"obj":"https://glytoucan.org/Structures/Glycans/G54161DR"}],"text":"Between days 11 and 12 of hospitalization, platelet count dropped from 304 000 to 96 000 cells/µL. He had a high pretest probability for HIT with a 4T score of 6. HIT antibody testing (anti-PF4/heparin antibody, by enzyme-linked immunosorbent assay) was sent, which returned positive with an optical density (OD) of 1.243 units. Heparin drip was discontinued and was switched to argatroban. Unfortunately, he died a day later, following a cardiac arrest. Serotonin release assay (SRA) eventually returned positive, with 49% serotonin release at low UFH dose (0.1 IU/mL) with a reduction to 0% release at high UFH dose (100 IU/mL). This confirmed the diagnosis of HIT."}

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T25","span":{"begin":43,"end":51},"obj":"Body_part"},{"id":"T26","span":{"begin":89,"end":94},"obj":"Body_part"},{"id":"T27","span":{"begin":167,"end":175},"obj":"Body_part"},{"id":"T28","span":{"begin":194,"end":201},"obj":"Body_part"},{"id":"T29","span":{"begin":202,"end":210},"obj":"Body_part"},{"id":"T30","span":{"begin":329,"end":336},"obj":"Body_part"},{"id":"T31","span":{"begin":455,"end":464},"obj":"Body_part"},{"id":"T32","span":{"begin":524,"end":533},"obj":"Body_part"}],"attributes":[{"id":"A25","pred":"fma_id","subj":"T25","obj":"http://purl.org/sig/ont/fma/fma62851"},{"id":"A26","pred":"fma_id","subj":"T26","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A27","pred":"fma_id","subj":"T27","obj":"http://purl.org/sig/ont/fma/fma62871"},{"id":"A28","pred":"fma_id","subj":"T28","obj":"http://purl.org/sig/ont/fma/fma82839"},{"id":"A29","pred":"fma_id","subj":"T29","obj":"http://purl.org/sig/ont/fma/fma62871"},{"id":"A30","pred":"fma_id","subj":"T30","obj":"http://purl.org/sig/ont/fma/fma82839"},{"id":"A31","pred":"fma_id","subj":"T31","obj":"http://purl.org/sig/ont/fma/fma67245"},{"id":"A32","pred":"fma_id","subj":"T32","obj":"http://purl.org/sig/ont/fma/fma67245"}],"text":"Between days 11 and 12 of hospitalization, platelet count dropped from 304 000 to 96 000 cells/µL. He had a high pretest probability for HIT with a 4T score of 6. HIT antibody testing (anti-PF4/heparin antibody, by enzyme-linked immunosorbent assay) was sent, which returned positive with an optical density (OD) of 1.243 units. Heparin drip was discontinued and was switched to argatroban. Unfortunately, he died a day later, following a cardiac arrest. Serotonin release assay (SRA) eventually returned positive, with 49% serotonin release at low UFH dose (0.1 IU/mL) with a reduction to 0% release at high UFH dose (100 IU/mL). This confirmed the diagnosis of HIT."}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T48","span":{"begin":137,"end":140},"obj":"Disease"},{"id":"T49","span":{"begin":163,"end":166},"obj":"Disease"},{"id":"T50","span":{"begin":309,"end":311},"obj":"Disease"},{"id":"T51","span":{"begin":406,"end":408},"obj":"Disease"},{"id":"T52","span":{"begin":439,"end":453},"obj":"Disease"},{"id":"T53","span":{"begin":663,"end":666},"obj":"Disease"}],"attributes":[{"id":"A48","pred":"mondo_id","subj":"T48","obj":"http://purl.obolibrary.org/obo/MONDO_0018048"},{"id":"A49","pred":"mondo_id","subj":"T49","obj":"http://purl.obolibrary.org/obo/MONDO_0018048"},{"id":"A50","pred":"mondo_id","subj":"T50","obj":"http://purl.obolibrary.org/obo/MONDO_0017178"},{"id":"A51","pred":"mondo_id","subj":"T51","obj":"http://purl.obolibrary.org/obo/MONDO_0017319"},{"id":"A52","pred":"mondo_id","subj":"T52","obj":"http://purl.obolibrary.org/obo/MONDO_0000745"},{"id":"A53","pred":"mondo_id","subj":"T53","obj":"http://purl.obolibrary.org/obo/MONDO_0018048"}],"text":"Between days 11 and 12 of hospitalization, platelet count dropped from 304 000 to 96 000 cells/µL. He had a high pretest probability for HIT with a 4T score of 6. HIT antibody testing (anti-PF4/heparin antibody, by enzyme-linked immunosorbent assay) was sent, which returned positive with an optical density (OD) of 1.243 units. Heparin drip was discontinued and was switched to argatroban. Unfortunately, he died a day later, following a cardiac arrest. Serotonin release assay (SRA) eventually returned positive, with 49% serotonin release at low UFH dose (0.1 IU/mL) with a reduction to 0% release at high UFH dose (100 IU/mL). This confirmed the diagnosis of HIT."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T46","span":{"begin":13,"end":15},"obj":"http://purl.obolibrary.org/obo/CLO_0053733"},{"id":"T47","span":{"begin":89,"end":94},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T48","span":{"begin":106,"end":107},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T49","span":{"begin":146,"end":147},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T50","span":{"begin":176,"end":183},"obj":"http://purl.obolibrary.org/obo/UBERON_0000473"},{"id":"T51","span":{"begin":414,"end":415},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T52","span":{"begin":437,"end":438},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T53","span":{"begin":455,"end":464},"obj":"http://purl.obolibrary.org/obo/CHEBI_28790"},{"id":"T54","span":{"begin":524,"end":533},"obj":"http://purl.obolibrary.org/obo/CHEBI_28790"},{"id":"T55","span":{"begin":575,"end":576},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"}],"text":"Between days 11 and 12 of hospitalization, platelet count dropped from 304 000 to 96 000 cells/µL. He had a high pretest probability for HIT with a 4T score of 6. HIT antibody testing (anti-PF4/heparin antibody, by enzyme-linked immunosorbent assay) was sent, which returned positive with an optical density (OD) of 1.243 units. Heparin drip was discontinued and was switched to argatroban. Unfortunately, he died a day later, following a cardiac arrest. Serotonin release assay (SRA) eventually returned positive, with 49% serotonin release at low UFH dose (0.1 IU/mL) with a reduction to 0% release at high UFH dose (100 IU/mL). This confirmed the diagnosis of HIT."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T16","span":{"begin":194,"end":201},"obj":"Chemical"},{"id":"T17","span":{"begin":329,"end":336},"obj":"Chemical"},{"id":"T18","span":{"begin":379,"end":389},"obj":"Chemical"},{"id":"T19","span":{"begin":455,"end":464},"obj":"Chemical"},{"id":"T20","span":{"begin":524,"end":533},"obj":"Chemical"}],"attributes":[{"id":"A16","pred":"chebi_id","subj":"T16","obj":"http://purl.obolibrary.org/obo/CHEBI_28304"},{"id":"A17","pred":"chebi_id","subj":"T17","obj":"http://purl.obolibrary.org/obo/CHEBI_28304"},{"id":"A18","pred":"chebi_id","subj":"T18","obj":"http://purl.obolibrary.org/obo/CHEBI_48720"},{"id":"A19","pred":"chebi_id","subj":"T19","obj":"http://purl.obolibrary.org/obo/CHEBI_28790"},{"id":"A20","pred":"chebi_id","subj":"T20","obj":"http://purl.obolibrary.org/obo/CHEBI_28790"},{"id":"A21","pred":"chebi_id","subj":"T20","obj":"http://purl.obolibrary.org/obo/CHEBI_350546"}],"text":"Between days 11 and 12 of hospitalization, platelet count dropped from 304 000 to 96 000 cells/µL. He had a high pretest probability for HIT with a 4T score of 6. HIT antibody testing (anti-PF4/heparin antibody, by enzyme-linked immunosorbent assay) was sent, which returned positive with an optical density (OD) of 1.243 units. Heparin drip was discontinued and was switched to argatroban. Unfortunately, he died a day later, following a cardiac arrest. Serotonin release assay (SRA) eventually returned positive, with 49% serotonin release at low UFH dose (0.1 IU/mL) with a reduction to 0% release at high UFH dose (100 IU/mL). This confirmed the diagnosis of HIT."}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T7","span":{"begin":455,"end":472},"obj":"http://purl.obolibrary.org/obo/GO_0001820"},{"id":"T8","span":{"begin":524,"end":541},"obj":"http://purl.obolibrary.org/obo/GO_0001820"}],"text":"Between days 11 and 12 of hospitalization, platelet count dropped from 304 000 to 96 000 cells/µL. He had a high pretest probability for HIT with a 4T score of 6. HIT antibody testing (anti-PF4/heparin antibody, by enzyme-linked immunosorbent assay) was sent, which returned positive with an optical density (OD) of 1.243 units. Heparin drip was discontinued and was switched to argatroban. Unfortunately, he died a day later, following a cardiac arrest. Serotonin release assay (SRA) eventually returned positive, with 49% serotonin release at low UFH dose (0.1 IU/mL) with a reduction to 0% release at high UFH dose (100 IU/mL). This confirmed the diagnosis of HIT."}

{"project":"LitCovid-sentences","denotations":[{"id":"T37","span":{"begin":0,"end":98},"obj":"Sentence"},{"id":"T38","span":{"begin":99,"end":162},"obj":"Sentence"},{"id":"T39","span":{"begin":163,"end":328},"obj":"Sentence"},{"id":"T40","span":{"begin":329,"end":390},"obj":"Sentence"},{"id":"T41","span":{"begin":391,"end":454},"obj":"Sentence"},{"id":"T42","span":{"begin":455,"end":630},"obj":"Sentence"},{"id":"T43","span":{"begin":631,"end":667},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Between days 11 and 12 of hospitalization, platelet count dropped from 304 000 to 96 000 cells/µL. He had a high pretest probability for HIT with a 4T score of 6. HIT antibody testing (anti-PF4/heparin antibody, by enzyme-linked immunosorbent assay) was sent, which returned positive with an optical density (OD) of 1.243 units. Heparin drip was discontinued and was switched to argatroban. Unfortunately, he died a day later, following a cardiac arrest. Serotonin release assay (SRA) eventually returned positive, with 49% serotonin release at low UFH dose (0.1 IU/mL) with a reduction to 0% release at high UFH dose (100 IU/mL). This confirmed the diagnosis of HIT."}

{"project":"LitCovid-PD-HP","denotations":[{"id":"T29","span":{"begin":137,"end":140},"obj":"Phenotype"},{"id":"T30","span":{"begin":163,"end":166},"obj":"Phenotype"},{"id":"T31","span":{"begin":439,"end":453},"obj":"Phenotype"},{"id":"T32","span":{"begin":663,"end":666},"obj":"Phenotype"}],"attributes":[{"id":"A29","pred":"hp_id","subj":"T29","obj":"http://purl.obolibrary.org/obo/HP_0011874"},{"id":"A30","pred":"hp_id","subj":"T30","obj":"http://purl.obolibrary.org/obo/HP_0011874"},{"id":"A31","pred":"hp_id","subj":"T31","obj":"http://purl.obolibrary.org/obo/HP_0001695"},{"id":"A32","pred":"hp_id","subj":"T32","obj":"http://purl.obolibrary.org/obo/HP_0011874"}],"text":"Between days 11 and 12 of hospitalization, platelet count dropped from 304 000 to 96 000 cells/µL. He had a high pretest probability for HIT with a 4T score of 6. HIT antibody testing (anti-PF4/heparin antibody, by enzyme-linked immunosorbent assay) was sent, which returned positive with an optical density (OD) of 1.243 units. Heparin drip was discontinued and was switched to argatroban. Unfortunately, he died a day later, following a cardiac arrest. Serotonin release assay (SRA) eventually returned positive, with 49% serotonin release at low UFH dose (0.1 IU/mL) with a reduction to 0% release at high UFH dose (100 IU/mL). This confirmed the diagnosis of HIT."}

{"project":"LitCovid-PubTator","denotations":[{"id":"152","span":{"begin":190,"end":193},"obj":"Gene"},{"id":"153","span":{"begin":194,"end":201},"obj":"Chemical"},{"id":"154","span":{"begin":329,"end":336},"obj":"Chemical"},{"id":"155","span":{"begin":379,"end":389},"obj":"Chemical"},{"id":"156","span":{"begin":455,"end":464},"obj":"Chemical"},{"id":"157","span":{"begin":524,"end":533},"obj":"Chemical"},{"id":"158","span":{"begin":549,"end":552},"obj":"Chemical"},{"id":"159","span":{"begin":609,"end":612},"obj":"Chemical"},{"id":"160","span":{"begin":137,"end":140},"obj":"Disease"},{"id":"161","span":{"begin":163,"end":166},"obj":"Disease"},{"id":"162","span":{"begin":439,"end":453},"obj":"Disease"},{"id":"163","span":{"begin":663,"end":666},"obj":"Disease"}],"attributes":[{"id":"A152","pred":"tao:has_database_id","subj":"152","obj":"Gene:5196"},{"id":"A153","pred":"tao:has_database_id","subj":"153","obj":"MESH:D006493"},{"id":"A154","pred":"tao:has_database_id","subj":"154","obj":"MESH:D006493"},{"id":"A155","pred":"tao:has_database_id","subj":"155","obj":"MESH:C031942"},{"id":"A156","pred":"tao:has_database_id","subj":"156","obj":"MESH:D012701"},{"id":"A157","pred":"tao:has_database_id","subj":"157","obj":"MESH:D012701"},{"id":"A158","pred":"tao:has_database_id","subj":"158","obj":"MESH:D006493"},{"id":"A159","pred":"tao:has_database_id","subj":"159","obj":"MESH:D006493"},{"id":"A160","pred":"tao:has_database_id","subj":"160","obj":"MESH:D013921"},{"id":"A161","pred":"tao:has_database_id","subj":"161","obj":"MESH:D013921"},{"id":"A162","pred":"tao:has_database_id","subj":"162","obj":"MESH:D006323"},{"id":"A163","pred":"tao:has_database_id","subj":"163","obj":"MESH:D013921"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"Between days 11 and 12 of hospitalization, platelet count dropped from 304 000 to 96 000 cells/µL. He had a high pretest probability for HIT with a 4T score of 6. HIT antibody testing (anti-PF4/heparin antibody, by enzyme-linked immunosorbent assay) was sent, which returned positive with an optical density (OD) of 1.243 units. Heparin drip was discontinued and was switched to argatroban. Unfortunately, he died a day later, following a cardiac arrest. Serotonin release assay (SRA) eventually returned positive, with 49% serotonin release at low UFH dose (0.1 IU/mL) with a reduction to 0% release at high UFH dose (100 IU/mL). This confirmed the diagnosis of HIT."}