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PMC:7386875 / 96-2349 JSONTXT

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LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T1 684-701 Body_part denotes endothelial cells http://purl.org/sig/ont/fma/fma66772
T2 696-701 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T3 773-789 Body_part denotes endothelial cell http://purl.org/sig/ont/fma/fma66772
T4 785-789 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T5 919-927 Body_part denotes platelet http://purl.org/sig/ont/fma/fma62851
T6 933-942 Body_part denotes leukocyte http://purl.org/sig/ont/fma/fma62852
T7 1111-1115 Body_part denotes vein http://purl.org/sig/ont/fma/fma50723
T8 1225-1231 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T9 1591-1598 Body_part denotes heparin http://purl.org/sig/ont/fma/fma82839

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 1106-1115 Body_part denotes deep vein http://purl.obolibrary.org/obo/UBERON_0035552
T2 1111-1115 Body_part denotes vein http://purl.obolibrary.org/obo/UBERON_0001638

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T3 24-71 Disease denotes severe acute respiratory syndrome coronavirus 2 http://purl.obolibrary.org/obo/MONDO_0100096
T4 24-57 Disease denotes severe acute respiratory syndrome http://purl.obolibrary.org/obo/MONDO_0005091
T5 73-81 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T6 220-244 Disease denotes coronavirus disease 2019 http://purl.obolibrary.org/obo/MONDO_0100096
T7 246-254 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T8 349-359 Disease denotes thrombosis http://purl.obolibrary.org/obo/MONDO_0000831
T9 361-382 Disease denotes venous thromboembolic http://purl.obolibrary.org/obo/MONDO_0005399
T10 396-402 Disease denotes stroke http://purl.obolibrary.org/obo/MONDO_0005098|http://purl.obolibrary.org/obo/MONDO_0011057
T12 464-472 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T13 497-515 Disease denotes multiorgan failure http://purl.obolibrary.org/obo/MONDO_0043726
T14 628-636 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T15 663-671 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T16 825-833 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T17 861-873 Disease denotes inflammation http://purl.obolibrary.org/obo/MONDO_0021166
T18 1116-1126 Disease denotes thrombosis http://purl.obolibrary.org/obo/MONDO_0000831
T19 1128-1146 Disease denotes pulmonary embolism http://purl.obolibrary.org/obo/MONDO_0005279
T20 1152-1158 Disease denotes stroke http://purl.obolibrary.org/obo/MONDO_0005098|http://purl.obolibrary.org/obo/MONDO_0011057
T22 1245-1261 Disease denotes thrombocytopenia http://purl.obolibrary.org/obo/MONDO_0002049
T23 1300-1308 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T24 1396-1404 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T25 1428-1438 Disease denotes thrombosis http://purl.obolibrary.org/obo/MONDO_0000831
T26 1549-1557 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T27 1569-1579 Disease denotes thrombosis http://purl.obolibrary.org/obo/MONDO_0000831
T28 1828-1836 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T29 2244-2252 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T1 117-120 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T2 131-132 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T3 199-202 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T4 275-276 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T5 684-701 http://purl.obolibrary.org/obo/CL_0000115 denotes endothelial cells
T6 773-789 http://purl.obolibrary.org/obo/CL_0000115 denotes endothelial cell
T7 886-896 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T8 1111-1115 http://purl.obolibrary.org/obo/UBERON_0001638 denotes vein
T9 1111-1115 http://www.ebi.ac.uk/efo/EFO_0000816 denotes vein
T10 1177-1187 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T11 1225-1231 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T1 713-724 Chemical denotes angiotensin http://purl.obolibrary.org/obo/CHEBI_48433
T2 1490-1495 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T3 1591-1598 Chemical denotes heparin http://purl.obolibrary.org/obo/CHEBI_28304
T4 1605-1615 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T5 1630-1635 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T6 1637-1647 Chemical denotes nafamostat http://purl.obolibrary.org/obo/CHEBI_135466
T7 1653-1665 Chemical denotes dipyridamole http://purl.obolibrary.org/obo/CHEBI_4653
T8 1727-1736 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T9 1981-1986 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T1 368-390 Phenotype denotes thromboembolic disease http://purl.obolibrary.org/obo/HP_0001907
T2 396-402 Phenotype denotes stroke http://purl.obolibrary.org/obo/HP_0001297
T3 1106-1126 Phenotype denotes deep vein thrombosis http://purl.obolibrary.org/obo/HP_0002625
T4 1128-1146 Phenotype denotes pulmonary embolism http://purl.obolibrary.org/obo/HP_0002204
T5 1152-1158 Phenotype denotes stroke http://purl.obolibrary.org/obo/HP_0001297
T6 1245-1261 Phenotype denotes thrombocytopenia http://purl.obolibrary.org/obo/HP_0001873

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T1 861-873 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T2 875-896 http://purl.obolibrary.org/obo/GO_0006956 denotes complement activation
T3 989-1014 http://purl.obolibrary.org/obo/GO_0002250 denotes adaptive immune responses
T4 1177-1202 http://purl.obolibrary.org/obo/GO_0050820 denotes activation of coagulation
T5 1191-1202 http://purl.obolibrary.org/obo/GO_0050817 denotes coagulation

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T3 0-177 Sentence denotes The recent emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and the ensuing global pandemic has presented a health emergency of unprecedented magnitude.
T4 178-403 Sentence denotes Recent clinical data has highlighted that coronavirus disease 2019 (COVID-19) is associated with a significant risk of thrombotic complications ranging from microvascular thrombosis, venous thromboembolic disease, and stroke.
T5 404-540 Sentence denotes Importantly, thrombotic complications are markers of severe COVID-19 and are associated with multiorgan failure and increased mortality.
T6 541-798 Sentence denotes The evidence to date supports the concept that the thrombotic manifestations of severe COVID-19 are due to the ability of SARS-CoV-2 to invade endothelial cells via ACE-2 (angiotensin-converting enzyme 2), which is expressed on the endothelial cell surface.
T7 799-1159 Sentence denotes However, in patients with COVID-19 the subsequent endothelial inflammation, complement activation, thrombin generation, platelet, and leukocyte recruitment, and the initiation of innate and adaptive immune responses culminate in immunothrombosis, ultimately causing (micro)thrombotic complications, such as deep vein thrombosis, pulmonary embolism, and stroke.
T8 1160-1309 Sentence denotes Accordingly, the activation of coagulation (eg, as measured with plasma D-dimer) and thrombocytopenia have emerged as prognostic markers in COVID-19.
T9 1310-1466 Sentence denotes Given thrombotic complications are central determinants of the high mortality rate in COVID-19, strategies to prevent thrombosis are of critical importance.
T10 1467-1745 Sentence denotes Several antithrombotic drugs have been proposed as potential therapies to prevent COVID-19-associated thrombosis, including heparin, FXII inhibitors, fibrinolytic drugs, nafamostat, and dipyridamole, many of which also possess pleiotropic anti-inflammatory or antiviral effects.
T11 1746-2052 Sentence denotes The growing awareness and mechanistic understanding of the prothrombotic state of COVID-19 patients are driving efforts to more stringent diagnostic screening for thrombotic complications and to the early institution of antithrombotic drugs, for both the prevention and therapy of thrombotic complications.
T12 2053-2253 Sentence denotes The shifting paradigm of diagnostic and treatment strategies holds significant promise to reduce the burden of thrombotic complications and ultimately improve the prognosis for patients with COVID-19.

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
48 706-711 Gene denotes ACE-2 Gene:59272
49 713-744 Gene denotes angiotensin-converting enzyme 2 Gene:59272
50 898-906 Gene denotes thrombin Gene:2147
51 24-71 Species denotes severe acute respiratory syndrome coronavirus 2 Tax:2697049
52 73-83 Species denotes SARS-CoV-2 Tax:2697049
53 663-673 Species denotes SARS-CoV-2 Tax:2697049
54 811-819 Species denotes patients Tax:9606
55 1837-1845 Species denotes patients Tax:9606
56 2230-2238 Species denotes patients Tax:9606
57 1591-1598 Chemical denotes heparin MESH:D006493
58 1637-1647 Chemical denotes nafamostat MESH:C032855
59 1653-1665 Chemical denotes dipyridamole MESH:D004176
60 220-244 Disease denotes coronavirus disease 2019 MESH:C000657245
61 246-254 Disease denotes COVID-19 MESH:C000657245
62 297-321 Disease denotes thrombotic complications MESH:D013927
63 349-359 Disease denotes thrombosis MESH:D013927
64 361-390 Disease denotes venous thromboembolic disease MESH:D054556
65 396-402 Disease denotes stroke MESH:D020521
66 417-441 Disease denotes thrombotic complications MESH:D013927
67 464-472 Disease denotes COVID-19 MESH:C000657245
68 497-515 Disease denotes multiorgan failure MESH:D009102
69 530-539 Disease denotes mortality MESH:D003643
70 592-602 Disease denotes thrombotic MESH:D013927
71 628-636 Disease denotes COVID-19 MESH:C000657245
72 825-833 Disease denotes COVID-19 MESH:C000657245
73 861-873 Disease denotes inflammation MESH:D007249
74 1028-1044 Disease denotes immunothrombosis
75 1072-1096 Disease denotes thrombotic complications MESH:D013927
76 1106-1126 Disease denotes deep vein thrombosis MESH:D020246
77 1128-1146 Disease denotes pulmonary embolism MESH:D011655
78 1152-1158 Disease denotes stroke MESH:D020521
79 1245-1261 Disease denotes thrombocytopenia MESH:D013921
80 1300-1308 Disease denotes COVID-19 MESH:C000657245
81 1316-1340 Disease denotes thrombotic complications MESH:D013927
82 1378-1387 Disease denotes mortality MESH:D003643
83 1396-1404 Disease denotes COVID-19 MESH:C000657245
84 1428-1438 Disease denotes thrombosis MESH:D013927
85 1549-1557 Disease denotes COVID-19 MESH:C000657245
86 1569-1579 Disease denotes thrombosis MESH:D013927
87 1828-1836 Disease denotes COVID-19 MESH:C000657245
88 1909-1933 Disease denotes thrombotic complications MESH:D013927
89 2027-2051 Disease denotes thrombotic complications MESH:D013927
90 2164-2188 Disease denotes thrombotic complications MESH:D013927
91 2244-2252 Disease denotes COVID-19 MESH:C000657245