PMC:7386875 / 6606-7287 JSONTXT

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T20","span":{"begin":18,"end":25},"obj":"Body_part"},{"id":"T21","span":{"begin":102,"end":108},"obj":"Body_part"}],"attributes":[{"id":"A20","pred":"fma_id","subj":"T20","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A21","pred":"fma_id","subj":"T21","obj":"http://purl.org/sig/ont/fma/fma82764"}],"text":"Cleavage of the S protein by cellular proteases, including furin and TMPRSS-2 (transmembrane protease serine 2), is speculated to play an important role in the infectivity and host range of SARS-CoV-2, although its functional significance regarding how this feature may mediate SAR-CoV-2 transmissibility and pathogenicity is yet be fully elucidated.1 In the context of COVID-19-associated thrombosis, understanding how these structural differences of SARS-CoV-2 may relate to the prothrombotic phenotype of COVID-19 is likely to be of fundamental importance given the significantly higher rates of thrombosis observed in SARS-CoV-2, compared with SARS-CoV and MERS-CoV infections."}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T77","span":{"begin":190,"end":198},"obj":"Disease"},{"id":"T78","span":{"begin":370,"end":378},"obj":"Disease"},{"id":"T79","span":{"begin":390,"end":400},"obj":"Disease"},{"id":"T80","span":{"begin":452,"end":460},"obj":"Disease"},{"id":"T81","span":{"begin":508,"end":516},"obj":"Disease"},{"id":"T82","span":{"begin":599,"end":609},"obj":"Disease"},{"id":"T83","span":{"begin":622,"end":630},"obj":"Disease"},{"id":"T84","span":{"begin":648,"end":656},"obj":"Disease"},{"id":"T85","span":{"begin":670,"end":680},"obj":"Disease"}],"attributes":[{"id":"A77","pred":"mondo_id","subj":"T77","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A78","pred":"mondo_id","subj":"T78","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A79","pred":"mondo_id","subj":"T79","obj":"http://purl.obolibrary.org/obo/MONDO_0000831"},{"id":"A80","pred":"mondo_id","subj":"T80","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A81","pred":"mondo_id","subj":"T81","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A82","pred":"mondo_id","subj":"T82","obj":"http://purl.obolibrary.org/obo/MONDO_0000831"},{"id":"A83","pred":"mondo_id","subj":"T83","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A84","pred":"mondo_id","subj":"T84","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A85","pred":"mondo_id","subj":"T85","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"}],"text":"Cleavage of the S protein by cellular proteases, including furin and TMPRSS-2 (transmembrane protease serine 2), is speculated to play an important role in the infectivity and host range of SARS-CoV-2, although its functional significance regarding how this feature may mediate SAR-CoV-2 transmissibility and pathogenicity is yet be fully elucidated.1 In the context of COVID-19-associated thrombosis, understanding how these structural differences of SARS-CoV-2 may relate to the prothrombotic phenotype of COVID-19 is likely to be of fundamental importance given the significantly higher rates of thrombosis observed in SARS-CoV-2, compared with SARS-CoV and MERS-CoV infections."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T24","span":{"begin":18,"end":25},"obj":"Chemical"},{"id":"T25","span":{"begin":102,"end":108},"obj":"Chemical"}],"attributes":[{"id":"A24","pred":"chebi_id","subj":"T24","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A25","pred":"chebi_id","subj":"T25","obj":"http://purl.obolibrary.org/obo/CHEBI_17822"}],"text":"Cleavage of the S protein by cellular proteases, including furin and TMPRSS-2 (transmembrane protease serine 2), is speculated to play an important role in the infectivity and host range of SARS-CoV-2, although its functional significance regarding how this feature may mediate SAR-CoV-2 transmissibility and pathogenicity is yet be fully elucidated.1 In the context of COVID-19-associated thrombosis, understanding how these structural differences of SARS-CoV-2 may relate to the prothrombotic phenotype of COVID-19 is likely to be of fundamental importance given the significantly higher rates of thrombosis observed in SARS-CoV-2, compared with SARS-CoV and MERS-CoV infections."}

{"project":"LitCovid-sentences","denotations":[{"id":"T31","span":{"begin":0,"end":681},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Cleavage of the S protein by cellular proteases, including furin and TMPRSS-2 (transmembrane protease serine 2), is speculated to play an important role in the infectivity and host range of SARS-CoV-2, although its functional significance regarding how this feature may mediate SAR-CoV-2 transmissibility and pathogenicity is yet be fully elucidated.1 In the context of COVID-19-associated thrombosis, understanding how these structural differences of SARS-CoV-2 may relate to the prothrombotic phenotype of COVID-19 is likely to be of fundamental importance given the significantly higher rates of thrombosis observed in SARS-CoV-2, compared with SARS-CoV and MERS-CoV infections."}

{"project":"2_test","denotations":[{"id":"32586214-32155444-21597670","span":{"begin":350,"end":351},"obj":"32155444"}],"text":"Cleavage of the S protein by cellular proteases, including furin and TMPRSS-2 (transmembrane protease serine 2), is speculated to play an important role in the infectivity and host range of SARS-CoV-2, although its functional significance regarding how this feature may mediate SAR-CoV-2 transmissibility and pathogenicity is yet be fully elucidated.1 In the context of COVID-19-associated thrombosis, understanding how these structural differences of SARS-CoV-2 may relate to the prothrombotic phenotype of COVID-19 is likely to be of fundamental importance given the significantly higher rates of thrombosis observed in SARS-CoV-2, compared with SARS-CoV and MERS-CoV infections."}

{"project":"LitCovid-PubTator","denotations":[{"id":"253","span":{"begin":59,"end":64},"obj":"Gene"},{"id":"254","span":{"begin":69,"end":77},"obj":"Gene"},{"id":"255","span":{"begin":79,"end":110},"obj":"Gene"},{"id":"256","span":{"begin":16,"end":17},"obj":"Gene"},{"id":"266","span":{"begin":190,"end":200},"obj":"Species"},{"id":"267","span":{"begin":278,"end":281},"obj":"Species"},{"id":"268","span":{"begin":282,"end":287},"obj":"Species"},{"id":"269","span":{"begin":452,"end":462},"obj":"Species"},{"id":"270","span":{"begin":622,"end":632},"obj":"Species"},{"id":"271","span":{"begin":648,"end":656},"obj":"Species"},{"id":"273","span":{"begin":370,"end":378},"obj":"Disease"},{"id":"274","span":{"begin":390,"end":400},"obj":"Disease"},{"id":"275","span":{"begin":508,"end":516},"obj":"Disease"},{"id":"276","span":{"begin":599,"end":609},"obj":"Disease"},{"id":"277","span":{"begin":661,"end":680},"obj":"Disease"}],"attributes":[{"id":"A253","pred":"tao:has_database_id","subj":"253","obj":"Gene:5045"},{"id":"A254","pred":"tao:has_database_id","subj":"254","obj":"Gene:7113"},{"id":"A255","pred":"tao:has_database_id","subj":"255","obj":"Gene:7113"},{"id":"A256","pred":"tao:has_database_id","subj":"256","obj":"Gene:43740568"},{"id":"A266","pred":"tao:has_database_id","subj":"266","obj":"Tax:2697049"},{"id":"A267","pred":"tao:has_database_id","subj":"267","obj":"Tax:2698737"},{"id":"A268","pred":"tao:has_database_id","subj":"268","obj":"Tax:2697049"},{"id":"A269","pred":"tao:has_database_id","subj":"269","obj":"Tax:2697049"},{"id":"A270","pred":"tao:has_database_id","subj":"270","obj":"Tax:2697049"},{"id":"A271","pred":"tao:has_database_id","subj":"271","obj":"Tax:694009"},{"id":"A273","pred":"tao:has_database_id","subj":"273","obj":"MESH:C000657245"},{"id":"A274","pred":"tao:has_database_id","subj":"274","obj":"MESH:D013927"},{"id":"A275","pred":"tao:has_database_id","subj":"275","obj":"MESH:C000657245"},{"id":"A276","pred":"tao:has_database_id","subj":"276","obj":"MESH:D013927"},{"id":"A277","pred":"tao:has_database_id","subj":"277","obj":"MESH:D018352"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"Cleavage of the S protein by cellular proteases, including furin and TMPRSS-2 (transmembrane protease serine 2), is speculated to play an important role in the infectivity and host range of SARS-CoV-2, although its functional significance regarding how this feature may mediate SAR-CoV-2 transmissibility and pathogenicity is yet be fully elucidated.1 In the context of COVID-19-associated thrombosis, understanding how these structural differences of SARS-CoV-2 may relate to the prothrombotic phenotype of COVID-19 is likely to be of fundamental importance given the significantly higher rates of thrombosis observed in SARS-CoV-2, compared with SARS-CoV and MERS-CoV infections."}