PMC:7386875 / 5844-7287
Annnotations
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T12 | 52-57 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T13 | 102-114 | Body_part | denotes | glycoprotein | http://purl.org/sig/ont/fma/fma62925 |
| T14 | 220-224 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
| T15 | 282-286 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
| T16 | 373-390 | Body_part | denotes | epithelial tissue | http://purl.org/sig/ont/fma/fma9639 |
| T17 | 435-440 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T18 | 532-542 | Body_part | denotes | amino acid | http://purl.org/sig/ont/fma/fma82739 |
| T19 | 602-609 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T20 | 780-787 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T21 | 864-870 | Body_part | denotes | serine | http://purl.org/sig/ont/fma/fma82764 |
LitCovid-PD-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T5 | 384-390 | Body_part | denotes | tissue | http://purl.obolibrary.org/obo/UBERON_0000479 |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T73 | 397-405 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T74 | 412-420 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T75 | 622-630 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T76 | 668-676 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T77 | 952-960 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T78 | 1132-1140 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T79 | 1152-1162 | Disease | denotes | thrombosis | http://purl.obolibrary.org/obo/MONDO_0000831 |
| T80 | 1214-1222 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T81 | 1270-1278 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T82 | 1361-1371 | Disease | denotes | thrombosis | http://purl.obolibrary.org/obo/MONDO_0000831 |
| T83 | 1384-1392 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T84 | 1410-1418 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T85 | 1432-1442 | Disease | denotes | infections | http://purl.obolibrary.org/obo/MONDO_0005550 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T34 | 3-9 | http://purl.obolibrary.org/obo/NCBITaxon_9606 | denotes | humans |
| T35 | 52-57 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T36 | 136-138 | http://purl.obolibrary.org/obo/CLO_0050050 | denotes | S1 |
| T37 | 143-145 | http://purl.obolibrary.org/obo/CLO_0008922 | denotes | S2 |
| T38 | 143-145 | http://purl.obolibrary.org/obo/CLO_0050052 | denotes | S2 |
| T39 | 170-172 | http://purl.obolibrary.org/obo/CLO_0050050 | denotes | S1 |
| T40 | 220-224 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
| T41 | 243-245 | http://purl.obolibrary.org/obo/CLO_0008922 | denotes | S2 |
| T42 | 243-245 | http://purl.obolibrary.org/obo/CLO_0050052 | denotes | S2 |
| T43 | 282-286 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
| T44 | 373-390 | http://purl.obolibrary.org/obo/UBERON_0000483 | denotes | epithelial tissue |
| T45 | 429-440 | http://purl.obolibrary.org/obo/CLO_0053065 | denotes | human cells |
| T46 | 532-551 | http://purl.obolibrary.org/obo/CHEBI_33708 | denotes | amino acid residues |
| T47 | 532-551 | http://purl.obolibrary.org/obo/PR_000036907 | denotes | amino acid residues |
| T48 | 699-700 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T49 | 739-747 | http://purl.obolibrary.org/obo/UBERON_0007651 | denotes | junction |
| T50 | 751-753 | http://purl.obolibrary.org/obo/CLO_0050050 | denotes | S1 |
| T51 | 758-760 | http://purl.obolibrary.org/obo/CLO_0008922 | denotes | S2 |
| T52 | 758-760 | http://purl.obolibrary.org/obo/CLO_0050052 | denotes | S2 |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T11 | 98-100 | Chemical | denotes | GP | http://purl.obolibrary.org/obo/CHEBI_70744 |
| T12 | 102-114 | Chemical | denotes | glycoprotein | http://purl.obolibrary.org/obo/CHEBI_17089 |
| T13 | 143-145 | Chemical | denotes | S2 | http://purl.obolibrary.org/obo/CHEBI_29387 |
| T14 | 243-245 | Chemical | denotes | S2 | http://purl.obolibrary.org/obo/CHEBI_29387 |
| T15 | 317-319 | Chemical | denotes | GP | http://purl.obolibrary.org/obo/CHEBI_70744 |
| T16 | 329-332 | Chemical | denotes | DPP | http://purl.obolibrary.org/obo/CHEBI_34680|http://purl.obolibrary.org/obo/CHEBI_60069 |
| T18 | 456-467 | Chemical | denotes | angiotensin | http://purl.obolibrary.org/obo/CHEBI_48433 |
| T19 | 532-542 | Chemical | denotes | amino acid | http://purl.obolibrary.org/obo/CHEBI_33709 |
| T20 | 532-537 | Chemical | denotes | amino | http://purl.obolibrary.org/obo/CHEBI_46882 |
| T21 | 538-542 | Chemical | denotes | acid | http://purl.obolibrary.org/obo/CHEBI_37527 |
| T22 | 602-609 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T23 | 758-760 | Chemical | denotes | S2 | http://purl.obolibrary.org/obo/CHEBI_29387 |
| T24 | 780-787 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T25 | 864-870 | Chemical | denotes | serine | http://purl.obolibrary.org/obo/CHEBI_17822 |
LitCovid-PD-GO-BP
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T9 | 36-51 | http://purl.obolibrary.org/obo/GO_0044409 | denotes | entry into host |
| T10 | 282-293 | http://purl.obolibrary.org/obo/GO_0140253 | denotes | cell fusion |
| T11 | 282-293 | http://purl.obolibrary.org/obo/GO_0045026 | denotes | cell fusion |
| T12 | 282-293 | http://purl.obolibrary.org/obo/GO_0000768 | denotes | cell fusion |
| T13 | 282-293 | http://purl.obolibrary.org/obo/GO_0000747 | denotes | cell fusion |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T29 | 0-165 | Sentence | denotes | In humans, these coronaviruses gain entry into host cells by way of their transmembrane spike (S) GP (glycoprotein), which comprises an S1 and S2 subunit (Figure 1). |
| T30 | 166-761 | Sentence | denotes | The S1 subunit is responsible for binding to the host cell receptor, and the S2 subunit assists with viral and host cell fusion.1 While the MERS-CoV S GP binds to DPP-4 (dipeptidyl peptidase 4) expressed on epithelial tissue, both SARS-CoV-2 and SARS-CoV bind to human cells via the ACE-2 (angiotensin-converting enzyme 2) receptor.5 In addition to having different amino acid residues within the RBD (receptor-binding domain) of the S protein compared to SARS-CoV, another novel structural feature of SARS-CoV-2, is the presence of a polybasic furin cleavage site, at the junction of S1 and S2. |
| T31 | 762-1443 | Sentence | denotes | Cleavage of the S protein by cellular proteases, including furin and TMPRSS-2 (transmembrane protease serine 2), is speculated to play an important role in the infectivity and host range of SARS-CoV-2, although its functional significance regarding how this feature may mediate SAR-CoV-2 transmissibility and pathogenicity is yet be fully elucidated.1 In the context of COVID-19-associated thrombosis, understanding how these structural differences of SARS-CoV-2 may relate to the prothrombotic phenotype of COVID-19 is likely to be of fundamental importance given the significantly higher rates of thrombosis observed in SARS-CoV-2, compared with SARS-CoV and MERS-CoV infections. |
2_test
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| 32586214-32155444-21597668 | 294-295 | 32155444 | denotes | 1 |
| 32586214-32142651-21597669 | 498-499 | 32142651 | denotes | 5 |
| 32586214-32155444-21597670 | 1112-1113 | 32155444 | denotes | 1 |
LitCovid-PubTator
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
|---|---|---|---|---|---|
| 249 | 329-334 | Gene | denotes | DPP-4 | Gene:1803 |
| 250 | 336-358 | Gene | denotes | dipeptidyl peptidase 4 | Gene:1803 |
| 251 | 449-454 | Gene | denotes | ACE-2 | Gene:59272 |
| 252 | 456-487 | Gene | denotes | angiotensin-converting enzyme 2 | Gene:59272 |
| 253 | 821-826 | Gene | denotes | furin | Gene:5045 |
| 254 | 831-839 | Gene | denotes | TMPRSS-2 | Gene:7113 |
| 255 | 841-872 | Gene | denotes | transmembrane protease serine 2 | Gene:7113 |
| 256 | 778-779 | Gene | denotes | S | Gene:43740568 |
| 257 | 711-716 | Gene | denotes | furin | Gene:5045 |
| 258 | 3-9 | Species | denotes | humans | Tax:9606 |
| 259 | 17-30 | Species | denotes | coronaviruses | Tax:11118 |
| 260 | 306-314 | Species | denotes | MERS-CoV | Tax:1335626 |
| 261 | 397-407 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
| 262 | 412-420 | Species | denotes | SARS-CoV | Tax:694009 |
| 263 | 429-434 | Species | denotes | human | Tax:9606 |
| 264 | 622-630 | Species | denotes | SARS-CoV | Tax:694009 |
| 265 | 668-678 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
| 266 | 952-962 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
| 267 | 1040-1043 | Species | denotes | SAR | Tax:2698737 |
| 268 | 1044-1049 | Species | denotes | CoV-2 | Tax:2697049 |
| 269 | 1214-1224 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
| 270 | 1384-1394 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
| 271 | 1410-1418 | Species | denotes | SARS-CoV | Tax:694009 |
| 272 | 88-93 | Gene | denotes | spike | Gene:43740568 |
| 273 | 1132-1140 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 274 | 1152-1162 | Disease | denotes | thrombosis | MESH:D013927 |
| 275 | 1270-1278 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 276 | 1361-1371 | Disease | denotes | thrombosis | MESH:D013927 |
| 277 | 1423-1442 | Disease | denotes | MERS-CoV infections | MESH:D018352 |