PMC:7386875 / 48017-48532 JSONTXT

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T472","span":{"begin":58,"end":66},"obj":"Body_part"},{"id":"T473","span":{"begin":317,"end":326},"obj":"Body_part"},{"id":"T474","span":{"begin":350,"end":357},"obj":"Body_part"},{"id":"T475","span":{"begin":385,"end":400},"obj":"Body_part"},{"id":"T476","span":{"begin":415,"end":429},"obj":"Body_part"},{"id":"T477","span":{"begin":441,"end":454},"obj":"Body_part"},{"id":"T478","span":{"begin":441,"end":445},"obj":"Body_part"},{"id":"T479","span":{"begin":459,"end":479},"obj":"Body_part"},{"id":"T480","span":{"begin":496,"end":508},"obj":"Body_part"}],"attributes":[{"id":"A472","pred":"fma_id","subj":"T472","obj":"http://purl.org/sig/ont/fma/fma82839"},{"id":"A473","pred":"fma_id","subj":"T473","obj":"http://purl.org/sig/ont/fma/fma84050"},{"id":"A474","pred":"fma_id","subj":"T474","obj":"http://purl.org/sig/ont/fma/fma82839"},{"id":"A475","pred":"fma_id","subj":"T475","obj":"http://purl.org/sig/ont/fma/fma63023"},{"id":"A476","pred":"fma_id","subj":"T476","obj":"http://purl.org/sig/ont/fma/fma82746"},{"id":"A477","pred":"fma_id","subj":"T477","obj":"http://purl.org/sig/ont/fma/fma67653"},{"id":"A478","pred":"fma_id","subj":"T478","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A479","pred":"fma_id","subj":"T479","obj":"http://purl.org/sig/ont/fma/fma9672"},{"id":"A480","pred":"fma_id","subj":"T480","obj":"http://purl.org/sig/ont/fma/fma82744"}],"text":"However, aside from their effects on anticoagulation, the heparins appear to have pleiotropic effects that may provide unique advantages in the context of viral infection, including anti-inflammatory effects by way of their ability to bind to danger-associated molecular patterns, such as HMGB-1, and proinflammatory cytokines.140,141 Unfractionated heparin has a similar structure as heparan sulfate, the sulfated polysaccharide present on cell surfaces and extracellular matrix, with repeating disaccharide units."}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T359","span":{"begin":155,"end":170},"obj":"Disease"},{"id":"T360","span":{"begin":161,"end":170},"obj":"Disease"}],"attributes":[{"id":"A359","pred":"mondo_id","subj":"T359","obj":"http://purl.obolibrary.org/obo/MONDO_0005108"},{"id":"A360","pred":"mondo_id","subj":"T360","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"}],"text":"However, aside from their effects on anticoagulation, the heparins appear to have pleiotropic effects that may provide unique advantages in the context of viral infection, including anti-inflammatory effects by way of their ability to bind to danger-associated molecular patterns, such as HMGB-1, and proinflammatory cytokines.140,141 Unfractionated heparin has a similar structure as heparan sulfate, the sulfated polysaccharide present on cell surfaces and extracellular matrix, with repeating disaccharide units."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T508","span":{"begin":358,"end":361},"obj":"http://purl.obolibrary.org/obo/CLO_0051582"},{"id":"T509","span":{"begin":362,"end":363},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T510","span":{"begin":441,"end":445},"obj":"http://purl.obolibrary.org/obo/GO_0005623"}],"text":"However, aside from their effects on anticoagulation, the heparins appear to have pleiotropic effects that may provide unique advantages in the context of viral infection, including anti-inflammatory effects by way of their ability to bind to danger-associated molecular patterns, such as HMGB-1, and proinflammatory cytokines.140,141 Unfractionated heparin has a similar structure as heparan sulfate, the sulfated polysaccharide present on cell surfaces and extracellular matrix, with repeating disaccharide units."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T286","span":{"begin":58,"end":66},"obj":"Chemical"},{"id":"T287","span":{"begin":350,"end":357},"obj":"Chemical"},{"id":"T288","span":{"begin":385,"end":400},"obj":"Chemical"},{"id":"T289","span":{"begin":385,"end":392},"obj":"Chemical"},{"id":"T290","span":{"begin":393,"end":400},"obj":"Chemical"},{"id":"T291","span":{"begin":415,"end":429},"obj":"Chemical"},{"id":"T292","span":{"begin":496,"end":508},"obj":"Chemical"}],"attributes":[{"id":"A286","pred":"chebi_id","subj":"T286","obj":"http://purl.obolibrary.org/obo/CHEBI_24505"},{"id":"A287","pred":"chebi_id","subj":"T287","obj":"http://purl.obolibrary.org/obo/CHEBI_28304"},{"id":"A288","pred":"chebi_id","subj":"T288","obj":"http://purl.obolibrary.org/obo/CHEBI_28815"},{"id":"A289","pred":"chebi_id","subj":"T289","obj":"http://purl.obolibrary.org/obo/CHEBI_24500"},{"id":"A290","pred":"chebi_id","subj":"T290","obj":"http://purl.obolibrary.org/obo/CHEBI_16189"},{"id":"A291","pred":"chebi_id","subj":"T291","obj":"http://purl.obolibrary.org/obo/CHEBI_18154"},{"id":"A292","pred":"chebi_id","subj":"T292","obj":"http://purl.obolibrary.org/obo/CHEBI_36233"}],"text":"However, aside from their effects on anticoagulation, the heparins appear to have pleiotropic effects that may provide unique advantages in the context of viral infection, including anti-inflammatory effects by way of their ability to bind to danger-associated molecular patterns, such as HMGB-1, and proinflammatory cytokines.140,141 Unfractionated heparin has a similar structure as heparan sulfate, the sulfated polysaccharide present on cell surfaces and extracellular matrix, with repeating disaccharide units."}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T153","span":{"begin":155,"end":170},"obj":"http://purl.obolibrary.org/obo/GO_0016032"}],"text":"However, aside from their effects on anticoagulation, the heparins appear to have pleiotropic effects that may provide unique advantages in the context of viral infection, including anti-inflammatory effects by way of their ability to bind to danger-associated molecular patterns, such as HMGB-1, and proinflammatory cytokines.140,141 Unfractionated heparin has a similar structure as heparan sulfate, the sulfated polysaccharide present on cell surfaces and extracellular matrix, with repeating disaccharide units."}

{"project":"LitCovid-PD-GlycoEpitope","denotations":[{"id":"T2","span":{"begin":385,"end":400},"obj":"GlycoEpitope"}],"attributes":[{"id":"A2","pred":"glyco_epitope_db_id","subj":"T2","obj":"http://www.glycoepitope.jp/epitopes/EP0086"}],"text":"However, aside from their effects on anticoagulation, the heparins appear to have pleiotropic effects that may provide unique advantages in the context of viral infection, including anti-inflammatory effects by way of their ability to bind to danger-associated molecular patterns, such as HMGB-1, and proinflammatory cytokines.140,141 Unfractionated heparin has a similar structure as heparan sulfate, the sulfated polysaccharide present on cell surfaces and extracellular matrix, with repeating disaccharide units."}

{"project":"LitCovid-sentences","denotations":[{"id":"T166","span":{"begin":0,"end":515},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"However, aside from their effects on anticoagulation, the heparins appear to have pleiotropic effects that may provide unique advantages in the context of viral infection, including anti-inflammatory effects by way of their ability to bind to danger-associated molecular patterns, such as HMGB-1, and proinflammatory cytokines.140,141 Unfractionated heparin has a similar structure as heparan sulfate, the sulfated polysaccharide present on cell surfaces and extracellular matrix, with repeating disaccharide units."}

{"project":"2_test","denotations":[{"id":"32586214-32188725-21597813","span":{"begin":327,"end":330},"obj":"32188725"},{"id":"32586214-27975101-21597814","span":{"begin":331,"end":334},"obj":"27975101"}],"text":"However, aside from their effects on anticoagulation, the heparins appear to have pleiotropic effects that may provide unique advantages in the context of viral infection, including anti-inflammatory effects by way of their ability to bind to danger-associated molecular patterns, such as HMGB-1, and proinflammatory cytokines.140,141 Unfractionated heparin has a similar structure as heparan sulfate, the sulfated polysaccharide present on cell surfaces and extracellular matrix, with repeating disaccharide units."}

{"project":"LitCovid-PubTator","denotations":[{"id":"1608","span":{"begin":289,"end":295},"obj":"Gene"},{"id":"1621","span":{"begin":58,"end":66},"obj":"Chemical"},{"id":"1622","span":{"begin":350,"end":357},"obj":"Chemical"},{"id":"1623","span":{"begin":385,"end":400},"obj":"Chemical"},{"id":"1624","span":{"begin":415,"end":429},"obj":"Chemical"},{"id":"1625","span":{"begin":496,"end":508},"obj":"Chemical"},{"id":"1642","span":{"begin":155,"end":170},"obj":"Disease"}],"attributes":[{"id":"A1608","pred":"tao:has_database_id","subj":"1608","obj":"Gene:3146"},{"id":"A1621","pred":"tao:has_database_id","subj":"1621","obj":"MESH:D006493"},{"id":"A1622","pred":"tao:has_database_id","subj":"1622","obj":"MESH:D006493"},{"id":"A1623","pred":"tao:has_database_id","subj":"1623","obj":"MESH:D006497"},{"id":"A1624","pred":"tao:has_database_id","subj":"1624","obj":"MESH:D011134"},{"id":"A1625","pred":"tao:has_database_id","subj":"1625","obj":"MESH:D004187"},{"id":"A1642","pred":"tao:has_database_id","subj":"1642","obj":"MESH:D001102"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"However, aside from their effects on anticoagulation, the heparins appear to have pleiotropic effects that may provide unique advantages in the context of viral infection, including anti-inflammatory effects by way of their ability to bind to danger-associated molecular patterns, such as HMGB-1, and proinflammatory cytokines.140,141 Unfractionated heparin has a similar structure as heparan sulfate, the sulfated polysaccharide present on cell surfaces and extracellular matrix, with repeating disaccharide units."}