PMC:7386875 / 42150-42511 JSONTXT

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T412","span":{"begin":105,"end":113},"obj":"Body_part"},{"id":"T413","span":{"begin":167,"end":184},"obj":"Body_part"},{"id":"T414","span":{"begin":179,"end":184},"obj":"Body_part"},{"id":"T415","span":{"begin":232,"end":242},"obj":"Body_part"},{"id":"T416","span":{"begin":280,"end":289},"obj":"Body_part"},{"id":"T417","span":{"begin":333,"end":342},"obj":"Body_part"}],"attributes":[{"id":"A412","pred":"fma_id","subj":"T412","obj":"http://purl.org/sig/ont/fma/fma62851"},{"id":"A413","pred":"fma_id","subj":"T413","obj":"http://purl.org/sig/ont/fma/fma66772"},{"id":"A414","pred":"fma_id","subj":"T414","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A415","pred":"fma_id","subj":"T415","obj":"http://purl.org/sig/ont/fma/fma62852"},{"id":"A416","pred":"fma_id","subj":"T416","obj":"http://purl.org/sig/ont/fma/fma84050"},{"id":"A417","pred":"fma_id","subj":"T417","obj":"http://purl.org/sig/ont/fma/fma62852"}],"text":"Thrombin efficiently cleaves and activates PAR-1, -3, and -4.131,132 Thus, in addition to being a potent platelet agonist, thrombin also activates immune effector and endothelial cells.133,134 Indeed, thrombin-induced activation of leukocytes results in the production of several cytokines and growth factors while also upregulating leukocyte adhesive function."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T453","span":{"begin":33,"end":42},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T454","span":{"begin":96,"end":97},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T455","span":{"begin":137,"end":146},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T456","span":{"begin":167,"end":184},"obj":"http://purl.obolibrary.org/obo/CL_0000115"},{"id":"T457","span":{"begin":218,"end":228},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"}],"text":"Thrombin efficiently cleaves and activates PAR-1, -3, and -4.131,132 Thus, in addition to being a potent platelet agonist, thrombin also activates immune effector and endothelial cells.133,134 Indeed, thrombin-induced activation of leukocytes results in the production of several cytokines and growth factors while also upregulating leukocyte adhesive function."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T220","span":{"begin":0,"end":8},"obj":"Chemical"},{"id":"T221","span":{"begin":114,"end":121},"obj":"Chemical"},{"id":"T222","span":{"begin":154,"end":162},"obj":"Chemical"}],"attributes":[{"id":"A220","pred":"chebi_id","subj":"T220","obj":"http://purl.obolibrary.org/obo/CHEBI_9574"},{"id":"A221","pred":"chebi_id","subj":"T221","obj":"http://purl.obolibrary.org/obo/CHEBI_48705"},{"id":"A222","pred":"chebi_id","subj":"T222","obj":"http://purl.obolibrary.org/obo/CHEBI_35224"}],"text":"Thrombin efficiently cleaves and activates PAR-1, -3, and -4.131,132 Thus, in addition to being a potent platelet agonist, thrombin also activates immune effector and endothelial cells.133,134 Indeed, thrombin-induced activation of leukocytes results in the production of several cytokines and growth factors while also upregulating leukocyte adhesive function."}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T136","span":{"begin":294,"end":300},"obj":"http://purl.obolibrary.org/obo/GO_0040007"},{"id":"T137","span":{"begin":320,"end":351},"obj":"http://purl.obolibrary.org/obo/GO_1903039"},{"id":"T138","span":{"begin":333,"end":351},"obj":"http://purl.obolibrary.org/obo/GO_0007159"}],"text":"Thrombin efficiently cleaves and activates PAR-1, -3, and -4.131,132 Thus, in addition to being a potent platelet agonist, thrombin also activates immune effector and endothelial cells.133,134 Indeed, thrombin-induced activation of leukocytes results in the production of several cytokines and growth factors while also upregulating leukocyte adhesive function."}

{"project":"LitCovid-sentences","denotations":[{"id":"T136","span":{"begin":0,"end":361},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Thrombin efficiently cleaves and activates PAR-1, -3, and -4.131,132 Thus, in addition to being a potent platelet agonist, thrombin also activates immune effector and endothelial cells.133,134 Indeed, thrombin-induced activation of leukocytes results in the production of several cytokines and growth factors while also upregulating leukocyte adhesive function."}

{"project":"2_test","denotations":[{"id":"32586214-10805786-21597803","span":{"begin":61,"end":64},"obj":"10805786"},{"id":"32586214-12511583-21597804","span":{"begin":65,"end":68},"obj":"12511583"},{"id":"32586214-18606855-21597805","span":{"begin":185,"end":188},"obj":"18606855"},{"id":"32586214-1385447-21597806","span":{"begin":189,"end":192},"obj":"1385447"}],"text":"Thrombin efficiently cleaves and activates PAR-1, -3, and -4.131,132 Thus, in addition to being a potent platelet agonist, thrombin also activates immune effector and endothelial cells.133,134 Indeed, thrombin-induced activation of leukocytes results in the production of several cytokines and growth factors while also upregulating leukocyte adhesive function."}

{"project":"LitCovid-PubTator","denotations":[{"id":"1397","span":{"begin":0,"end":8},"obj":"Gene"},{"id":"1398","span":{"begin":43,"end":60},"obj":"Gene"},{"id":"1399","span":{"begin":123,"end":131},"obj":"Gene"},{"id":"1400","span":{"begin":201,"end":209},"obj":"Gene"}],"attributes":[{"id":"A1397","pred":"tao:has_database_id","subj":"1397","obj":"Gene:2147"},{"id":"A1398","pred":"tao:has_database_id","subj":"1398","obj":"Gene:2149"},{"id":"A1399","pred":"tao:has_database_id","subj":"1399","obj":"Gene:2147"},{"id":"A1400","pred":"tao:has_database_id","subj":"1400","obj":"Gene:2147"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"Thrombin efficiently cleaves and activates PAR-1, -3, and -4.131,132 Thus, in addition to being a potent platelet agonist, thrombin also activates immune effector and endothelial cells.133,134 Indeed, thrombin-induced activation of leukocytes results in the production of several cytokines and growth factors while also upregulating leukocyte adhesive function."}