PMC:7386875 / 38651-40892
Annnotations
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T379 | 44-47 | Body_part | denotes | arm | http://purl.org/sig/ont/fma/fma24890 |
| T380 | 62-75 | Body_part | denotes | immune system | http://purl.org/sig/ont/fma/fma9825 |
| T381 | 593-600 | Body_part | denotes | mannose | http://purl.org/sig/ont/fma/fma82801 |
| T382 | 627-633 | Body_part | denotes | serine | http://purl.org/sig/ont/fma/fma82764 |
| T383 | 781-793 | Body_part | denotes | glycoprotein | http://purl.org/sig/ont/fma/fma62925 |
| T384 | 917-921 | Body_part | denotes | lung | http://purl.org/sig/ont/fma/fma7195 |
| T385 | 1085-1090 | Body_part | denotes | serum | http://purl.org/sig/ont/fma/fma63083 |
| T386 | 1171-1178 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T387 | 1265-1271 | Body_part | denotes | tissue | http://purl.org/sig/ont/fma/fma9637 |
| T388 | 1365-1374 | Body_part | denotes | cytokines | http://purl.org/sig/ont/fma/fma84050 |
| T389 | 1384-1388 | Body_part | denotes | IL-1 | http://purl.org/sig/ont/fma/fma86583 |
| T390 | 1510-1520 | Body_part | denotes | P-selectin | http://purl.org/sig/ont/fma/fma62933 |
| T391 | 1631-1640 | Body_part | denotes | monocytes | http://purl.org/sig/ont/fma/fma62864 |
| T392 | 1645-1656 | Body_part | denotes | neutrophils | http://purl.org/sig/ont/fma/fma62860 |
| T393 | 1749-1759 | Body_part | denotes | neutrophil | http://purl.org/sig/ont/fma/fma62860 |
| T394 | 1781-1789 | Body_part | denotes | monocyte | http://purl.org/sig/ont/fma/fma62864 |
| T395 | 1830-1838 | Body_part | denotes | platelet | http://purl.org/sig/ont/fma/fma62851 |
| T396 | 1955-1961 | Body_part | denotes | plasma | http://purl.org/sig/ont/fma/fma62970 |
LitCovid-PD-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T56 | 44-47 | Body_part | denotes | arm | http://purl.obolibrary.org/obo/UBERON_0001460 |
| T57 | 62-75 | Body_part | denotes | immune system | http://purl.obolibrary.org/obo/UBERON_0002405 |
| T58 | 694-701 | Body_part | denotes | vessels | http://purl.obolibrary.org/obo/UBERON_0000055 |
| T59 | 917-921 | Body_part | denotes | lung | http://purl.obolibrary.org/obo/UBERON_0002048 |
| T60 | 1085-1090 | Body_part | denotes | serum | http://purl.obolibrary.org/obo/UBERON_0001977 |
| T61 | 1265-1271 | Body_part | denotes | tissue | http://purl.obolibrary.org/obo/UBERON_0000479 |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T302 | 104-112 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T303 | 124-134 | Disease | denotes | thrombosis | http://purl.obolibrary.org/obo/MONDO_0000831 |
| T304 | 247-275 | Disease | denotes | thrombotic microangiopathies | http://purl.obolibrary.org/obo/MONDO_0019737 |
| T305 | 287-312 | Disease | denotes | antiphospholipid syndrome | http://purl.obolibrary.org/obo/MONDO_0007140 |
| T306 | 317-351 | Disease | denotes | atypical hemolytic uremic syndrome | http://purl.obolibrary.org/obo/MONDO_0016244 |
| T307 | 326-351 | Disease | denotes | hemolytic uremic syndrome | http://purl.obolibrary.org/obo/MONDO_0001549 |
| T308 | 434-442 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T309 | 764-772 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T310 | 957-965 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T311 | 1034-1042 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T312 | 1182-1190 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T313 | 1272-1278 | Disease | denotes | injury | http://purl.obolibrary.org/obo/MONDO_0021178 |
| T314 | 1973-1981 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T315 | 2172-2180 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T316 | 2209-2217 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T317 | 2227-2237 | Disease | denotes | thrombosis | http://purl.obolibrary.org/obo/MONDO_0000831 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T402 | 44-47 | http://www.ebi.ac.uk/efo/EFO_0001410 | denotes | arm |
| T403 | 62-75 | http://purl.obolibrary.org/obo/UBERON_0002405 | denotes | immune system |
| T404 | 81-84 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
| T405 | 136-146 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | Activation |
| T406 | 236-237 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T407 | 532-540 | http://purl.obolibrary.org/obo/UBERON_0000158 | denotes | membrane |
| T408 | 672-675 | http://purl.obolibrary.org/obo/CLO_0001053 | denotes | 121 |
| T409 | 694-701 | http://purl.obolibrary.org/obo/UBERON_0000055 | denotes | vessels |
| T410 | 828-829 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T411 | 846-849 | http://purl.obolibrary.org/obo/CLO_0001053 | denotes | 121 |
| T412 | 888-889 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T413 | 917-921 | http://purl.obolibrary.org/obo/UBERON_0002048 | denotes | lung |
| T414 | 917-921 | http://www.ebi.ac.uk/efo/EFO_0000934 | denotes | lung |
| T415 | 1126-1129 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
| T416 | 1239-1249 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activation |
| T417 | 1284-1294 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activation |
| T418 | 1390-1394 | http://purl.obolibrary.org/obo/CLO_0053704 | denotes | IL-8 |
| T419 | 1574-1577 | http://purl.obolibrary.org/obo/CLO_0002119 | denotes | C3a |
| T420 | 1617-1627 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activation |
| T421 | 1631-1640 | http://purl.obolibrary.org/obo/CL_0000576 | denotes | monocytes |
| T422 | 1669-1679 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activation |
| T423 | 1702-1703 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T424 | 1775-1780 | http://purl.obolibrary.org/obo/CLO_0002137 | denotes | C5b-7 |
| T425 | 1781-1789 | http://purl.obolibrary.org/obo/CL_0000576 | denotes | monocyte |
| T426 | 1839-1849 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activation |
| T427 | 1875-1878 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
| T428 | 1897-1898 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T429 | 1918-1927 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activator |
| T430 | 1955-1961 | http://purl.obolibrary.org/obo/UBERON_0001969 | denotes | plasma |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T201 | 593-600 | Chemical | denotes | mannose | http://purl.obolibrary.org/obo/CHEBI_37684 |
| T202 | 627-633 | Chemical | denotes | serine | http://purl.obolibrary.org/obo/CHEBI_17822 |
| T203 | 781-793 | Chemical | denotes | glycoprotein | http://purl.obolibrary.org/obo/CHEBI_17089 |
| T204 | 1171-1178 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T205 | 1384-1386 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
| T207 | 1390-1392 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
| T209 | 1404-1406 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
| T211 | 1414-1417 | Chemical | denotes | MCP | http://purl.obolibrary.org/obo/CHEBI_132592|http://purl.obolibrary.org/obo/CHEBI_50099 |
| T213 | 1491-1500 | Chemical | denotes | molecules | http://purl.obolibrary.org/obo/CHEBI_25367 |
| T214 | 1760-1762 | Chemical | denotes | TF | http://purl.obolibrary.org/obo/CHEBI_74862 |
| T215 | 1790-1792 | Chemical | denotes | TF | http://purl.obolibrary.org/obo/CHEBI_74862 |
LitCovid-PD-HP
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T60 | 326-351 | Phenotype | denotes | hemolytic uremic syndrome | http://purl.obolibrary.org/obo/HP_0005575 |
LitCovid-PD-GO-BP
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T120 | 4-22 | http://purl.obolibrary.org/obo/GO_0006956 | denotes | complement cascade |
| T121 | 55-68 | http://purl.obolibrary.org/obo/GO_0045087 | denotes | innate immune |
| T122 | 1228-1249 | http://purl.obolibrary.org/obo/GO_0006956 | denotes | complement activation |
| T123 | 1658-1679 | http://purl.obolibrary.org/obo/GO_0006956 | denotes | Complement activation |
| T124 | 1830-1849 | http://purl.obolibrary.org/obo/GO_0030168 | denotes | platelet activation |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T126 | 0-135 | Sentence | denotes | The complement cascade is another important arm of the innate immune system that has been implicated in COVID-19-associated thrombosis. |
| T127 | 136-1279 | Sentence | denotes | Activation of the complement system, and vascular deposition of complement components, is linked to a range of thrombotic microangiopathies, including antiphospholipid syndrome and atypical hemolytic uremic syndrome.120 Recent histological findings from biopsies obtained from patients with severe COVID-19 have demonstrated the extensive deposition of the terminal complement components, C5b-9 (membrane attack complex) and C4d, in addition to the MASP-2 (mannose-binding lectin-associated serine protease) within the microvasculature.121 Strikingly, these vessels largely exhibited microvascular thrombi and, furthermore, the SARS-CoV-2 spike glycoprotein colocalized with C5b-9 and C4d in a subset of cases.121 These findings appear consistent with a recent Chinese study where lung sections from patients with severe COVID-19 all revealed strong complement staining, while patients with severe COVID-19 have also been described to have elevated serum C5a levels.122 Mechanistically, it has been suggested that the nucleocapsid (N) protein of SARS-CoV-2 binds to MASP-2 thereby triggering complement activation and amplifying tissue injury. |
| T128 | 1280-1657 | Sentence | denotes | The activation of the complement pathway leads to enhanced production of endothelial cytokines, such as IL-1, IL-8, RANTES, IL-6, and MCP-1, and also upregulates the expression of important endothelial adhesion molecules, such as P-selectin and VWF.120,123 Moreover, the anaphylatoxins C5a and C3a, act to facilitate the recruitment and activation of monocytes and neutrophils. |
| T129 | 1658-2241 | Sentence | denotes | Complement activation also directly induces a prothrombotic phenotype via C5a induction of neutrophil TF expression, C5b-7 monocyte TF expression, and C5b-8/C5b-9 mediated platelet activation.124,125 Furthermore, CRP has been described as a complement pathway activator and the correlation of its plasma level with COVID-19 severity highlights another potential link between immune and complement system.72 These observations have attracted major interest in exploring the role of complement directed therapies in COVID-19 patients, in particular, in COVID-19 mediated thrombosis.126 |
2_test
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| 32586214-27126649-21597790 | 352-355 | 27126649 | denotes | 120 |
| 32586214-32299776-21597791 | 672-675 | 32299776 | denotes | 121 |
| 32586214-32299776-21597792 | 846-849 | 32299776 | denotes | 121 |
| 32586214-27126649-21597793 | 1529-1532 | 27126649 | denotes | 120 |
| 32586214-7521884-21597794 | 1533-1536 | 7521884 | denotes | 123 |
| 32586214-16982920-21597795 | 1850-1853 | 16982920 | denotes | 124 |
| 32586214-3092889-21597796 | 1854-1857 | 3092889 | denotes | 125 |
| 32586214-28112148-21597797 | 2062-2064 | 28112148 | denotes | 72 |
| 32586214-32271624-21597798 | 2238-2241 | 32271624 | denotes | 126 |
LitCovid-PubTator
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
|---|---|---|---|---|---|
| 1311 | 585-591 | Gene | denotes | MASP-2 | Gene:10747 |
| 1312 | 1091-1094 | Gene | denotes | C5a | Gene:728 |
| 1313 | 1168-1169 | Gene | denotes | N | Gene:43740575 |
| 1314 | 1202-1208 | Gene | denotes | MASP-2 | Gene:10747 |
| 1315 | 1384-1388 | Gene | denotes | IL-1 | Gene:3552 |
| 1316 | 1390-1394 | Gene | denotes | IL-8 | Gene:3576 |
| 1317 | 1396-1402 | Gene | denotes | RANTES | Gene:6352 |
| 1318 | 1404-1408 | Gene | denotes | IL-6 | Gene:3569 |
| 1319 | 1414-1419 | Gene | denotes | MCP-1 | Gene:6347 |
| 1320 | 1510-1520 | Gene | denotes | P-selectin | Gene:6403 |
| 1321 | 1525-1528 | Gene | denotes | VWF | Gene:7450 |
| 1322 | 1574-1577 | Gene | denotes | C3a | Gene:718 |
| 1323 | 1790-1792 | Gene | denotes | TF | Gene:2152 |
| 1324 | 1871-1874 | Gene | denotes | CRP | Gene:1401 |
| 1325 | 1732-1735 | Gene | denotes | C5a | Gene:728 |
| 1326 | 1566-1569 | Gene | denotes | C5a | Gene:728 |
| 1327 | 1760-1762 | Gene | denotes | TF | Gene:2152 |
| 1328 | 775-780 | Gene | denotes | spike | Gene:43740568 |
| 1329 | 413-421 | Species | denotes | patients | Tax:9606 |
| 1330 | 764-774 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
| 1331 | 936-944 | Species | denotes | patients | Tax:9606 |
| 1332 | 1013-1021 | Species | denotes | patients | Tax:9606 |
| 1333 | 1182-1192 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
| 1334 | 2181-2189 | Species | denotes | patients | Tax:9606 |
| 1335 | 593-600 | Chemical | denotes | mannose | MESH:D008358 |
| 1336 | 627-633 | Chemical | denotes | serine | MESH:D012694 |
| 1337 | 104-112 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 1338 | 124-134 | Disease | denotes | thrombosis | MESH:D013927 |
| 1339 | 247-275 | Disease | denotes | thrombotic microangiopathies | MESH:D057049 |
| 1340 | 287-312 | Disease | denotes | antiphospholipid syndrome | MESH:D016736 |
| 1341 | 317-351 | Disease | denotes | atypical hemolytic uremic syndrome | MESH:D065766 |
| 1342 | 434-442 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 1343 | 734-741 | Disease | denotes | thrombi | MESH:D013927 |
| 1344 | 957-965 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 1345 | 1034-1042 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 1346 | 1973-1981 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 1347 | 2172-2180 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 1348 | 2209-2217 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 1349 | 2227-2237 | Disease | denotes | thrombosis | MESH:D013927 |