PMC:7386875 / 373-925
Annnotations
{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7386875","sourcedb":"PMC","sourceid":"7386875","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7386875","text":"significant risk of thrombotic complications ranging from microvascular thrombosis, venous thromboembolic disease, and stroke. Importantly, thrombotic complications are markers of severe COVID-19 and are associated with multiorgan failure and increased mortality. The evidence to date supports the concept that the thrombotic manifestations of severe COVID-19 are due to the ability of SARS-CoV-2 to invade endothelial cells via ACE-2 (angiotensin-converting enzyme 2), which is expressed on the endothelial cell surface. However, in patients with COVI","tracks":[{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T1","span":{"begin":407,"end":424},"obj":"Body_part"},{"id":"T2","span":{"begin":419,"end":424},"obj":"Body_part"},{"id":"T3","span":{"begin":496,"end":512},"obj":"Body_part"},{"id":"T4","span":{"begin":508,"end":512},"obj":"Body_part"}],"attributes":[{"id":"A1","pred":"fma_id","subj":"T1","obj":"http://purl.org/sig/ont/fma/fma66772"},{"id":"A2","pred":"fma_id","subj":"T2","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A3","pred":"fma_id","subj":"T3","obj":"http://purl.org/sig/ont/fma/fma66772"},{"id":"A4","pred":"fma_id","subj":"T4","obj":"http://purl.org/sig/ont/fma/fma68646"},{"subj":"T1","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T2","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T3","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T4","pred":"source","obj":"LitCovid-PD-FMA-UBERON"}]},{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T8","span":{"begin":72,"end":82},"obj":"Disease"},{"id":"T9","span":{"begin":84,"end":105},"obj":"Disease"},{"id":"T10","span":{"begin":119,"end":125},"obj":"Disease"},{"id":"T12","span":{"begin":187,"end":195},"obj":"Disease"},{"id":"T13","span":{"begin":220,"end":238},"obj":"Disease"},{"id":"T14","span":{"begin":351,"end":359},"obj":"Disease"},{"id":"T15","span":{"begin":386,"end":394},"obj":"Disease"}],"attributes":[{"id":"A8","pred":"mondo_id","subj":"T8","obj":"http://purl.obolibrary.org/obo/MONDO_0000831"},{"id":"A9","pred":"mondo_id","subj":"T9","obj":"http://purl.obolibrary.org/obo/MONDO_0005399"},{"id":"A10","pred":"mondo_id","subj":"T10","obj":"http://purl.obolibrary.org/obo/MONDO_0005098"},{"id":"A11","pred":"mondo_id","subj":"T10","obj":"http://purl.obolibrary.org/obo/MONDO_0011057"},{"id":"A12","pred":"mondo_id","subj":"T12","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A13","pred":"mondo_id","subj":"T13","obj":"http://purl.obolibrary.org/obo/MONDO_0043726"},{"id":"A14","pred":"mondo_id","subj":"T14","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A15","pred":"mondo_id","subj":"T15","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"subj":"T8","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T9","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T10","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T12","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T13","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T14","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T15","pred":"source","obj":"LitCovid-PD-MONDO"}]},{"project":"LitCovid-PD-CLO","denotations":[{"id":"T5","span":{"begin":407,"end":424},"obj":"http://purl.obolibrary.org/obo/CL_0000115"},{"id":"T6","span":{"begin":496,"end":512},"obj":"http://purl.obolibrary.org/obo/CL_0000115"}],"attributes":[{"subj":"T5","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T6","pred":"source","obj":"LitCovid-PD-CLO"}]},{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T1","span":{"begin":436,"end":447},"obj":"Chemical"}],"attributes":[{"id":"A1","pred":"chebi_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/CHEBI_48433"},{"subj":"T1","pred":"source","obj":"LitCovid-PD-CHEBI"}]},{"project":"LitCovid-PD-HP","denotations":[{"id":"T1","span":{"begin":91,"end":113},"obj":"Phenotype"},{"id":"T2","span":{"begin":119,"end":125},"obj":"Phenotype"}],"attributes":[{"id":"A1","pred":"hp_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/HP_0001907"},{"id":"A2","pred":"hp_id","subj":"T2","obj":"http://purl.obolibrary.org/obo/HP_0001297"},{"subj":"T1","pred":"source","obj":"LitCovid-PD-HP"},{"subj":"T2","pred":"source","obj":"LitCovid-PD-HP"}]},{"project":"LitCovid-sentences","denotations":[{"id":"T5","span":{"begin":127,"end":263},"obj":"Sentence"},{"id":"T6","span":{"begin":264,"end":521},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T5","pred":"source","obj":"LitCovid-sentences"},{"subj":"T6","pred":"source","obj":"LitCovid-sentences"}]},{"project":"LitCovid-PubTator","denotations":[{"id":"48","span":{"begin":429,"end":434},"obj":"Gene"},{"id":"49","span":{"begin":436,"end":467},"obj":"Gene"},{"id":"53","span":{"begin":386,"end":396},"obj":"Species"},{"id":"54","span":{"begin":534,"end":542},"obj":"Species"},{"id":"62","span":{"begin":20,"end":44},"obj":"Disease"},{"id":"63","span":{"begin":72,"end":82},"obj":"Disease"},{"id":"64","span":{"begin":84,"end":113},"obj":"Disease"},{"id":"65","span":{"begin":119,"end":125},"obj":"Disease"},{"id":"66","span":{"begin":140,"end":164},"obj":"Disease"},{"id":"67","span":{"begin":187,"end":195},"obj":"Disease"},{"id":"68","span":{"begin":220,"end":238},"obj":"Disease"},{"id":"69","span":{"begin":253,"end":262},"obj":"Disease"},{"id":"70","span":{"begin":315,"end":325},"obj":"Disease"},{"id":"71","span":{"begin":351,"end":359},"obj":"Disease"}],"attributes":[{"id":"A48","pred":"tao:has_database_id","subj":"48","obj":"Gene:59272"},{"id":"A49","pred":"tao:has_database_id","subj":"49","obj":"Gene:59272"},{"id":"A53","pred":"tao:has_database_id","subj":"53","obj":"Tax:2697049"},{"id":"A54","pred":"tao:has_database_id","subj":"54","obj":"Tax:9606"},{"id":"A62","pred":"tao:has_database_id","subj":"62","obj":"MESH:D013927"},{"id":"A63","pred":"tao:has_database_id","subj":"63","obj":"MESH:D013927"},{"id":"A64","pred":"tao:has_database_id","subj":"64","obj":"MESH:D054556"},{"id":"A65","pred":"tao:has_database_id","subj":"65","obj":"MESH:D020521"},{"id":"A66","pred":"tao:has_database_id","subj":"66","obj":"MESH:D013927"},{"id":"A67","pred":"tao:has_database_id","subj":"67","obj":"MESH:C000657245"},{"id":"A68","pred":"tao:has_database_id","subj":"68","obj":"MESH:D009102"},{"id":"A69","pred":"tao:has_database_id","subj":"69","obj":"MESH:D003643"},{"id":"A70","pred":"tao:has_database_id","subj":"70","obj":"MESH:D013927"},{"id":"A71","pred":"tao:has_database_id","subj":"71","obj":"MESH:C000657245"},{"subj":"48","pred":"source","obj":"LitCovid-PubTator"},{"subj":"49","pred":"source","obj":"LitCovid-PubTator"},{"subj":"53","pred":"source","obj":"LitCovid-PubTator"},{"subj":"54","pred":"source","obj":"LitCovid-PubTator"},{"subj":"62","pred":"source","obj":"LitCovid-PubTator"},{"subj":"63","pred":"source","obj":"LitCovid-PubTator"},{"subj":"64","pred":"source","obj":"LitCovid-PubTator"},{"subj":"65","pred":"source","obj":"LitCovid-PubTator"},{"subj":"66","pred":"source","obj":"LitCovid-PubTator"},{"subj":"67","pred":"source","obj":"LitCovid-PubTator"},{"subj":"68","pred":"source","obj":"LitCovid-PubTator"},{"subj":"69","pred":"source","obj":"LitCovid-PubTator"},{"subj":"70","pred":"source","obj":"LitCovid-PubTator"},{"subj":"71","pred":"source","obj":"LitCovid-PubTator"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCovid-PD-FMA-UBERON","color":"#93ecbe","default":true},{"id":"LitCovid-PD-MONDO","color":"#eca493"},{"id":"LitCovid-PD-CLO","color":"#939bec"},{"id":"LitCovid-PD-CHEBI","color":"#b5ec93"},{"id":"LitCovid-PD-HP","color":"#ec93cf"},{"id":"LitCovid-sentences","color":"#93e9ec"},{"id":"LitCovid-PubTator","color":"#ecd493"}]}]}}