> top > docs > PMC:7386875 > spans > 36954-38583 > annotations

PMC:7386875 / 36954-38583 JSONTXT

Annnotations TAB JSON ListView MergeView

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T349 0-8 Body_part denotes Platelet http://purl.org/sig/ont/fma/fma62851
T350 9-17 Body_part denotes monocyte http://purl.org/sig/ont/fma/fma62864
T351 117-125 Body_part denotes platelet http://purl.org/sig/ont/fma/fma62851
T352 130-138 Body_part denotes monocyte http://purl.org/sig/ont/fma/fma62864
T353 184-193 Body_part denotes platelets http://purl.org/sig/ont/fma/fma62851
T354 201-209 Body_part denotes monocyte http://purl.org/sig/ont/fma/fma62864
T355 270-275 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T356 308-316 Body_part denotes monocyte http://purl.org/sig/ont/fma/fma62864
T357 384-393 Body_part denotes cytokines http://purl.org/sig/ont/fma/fma84050
T358 423-431 Body_part denotes platelet http://purl.org/sig/ont/fma/fma62851
T359 432-442 Body_part denotes P-selectin http://purl.org/sig/ont/fma/fma62933
T360 451-459 Body_part denotes monocyte http://purl.org/sig/ont/fma/fma62864
T361 508-516 Body_part denotes monocyte http://purl.org/sig/ont/fma/fma62864
T362 554-562 Body_part denotes platelet http://purl.org/sig/ont/fma/fma62851
T363 571-581 Body_part denotes chemokines http://purl.org/sig/ont/fma/fma241981
T364 609-617 Body_part denotes monocyte http://purl.org/sig/ont/fma/fma62864
T365 663-674 Body_part denotes macrophages http://purl.org/sig/ont/fma/fma63261
T366 699-708 Body_part denotes platelets http://purl.org/sig/ont/fma/fma62851
T367 749-760 Body_part denotes macrophages http://purl.org/sig/ont/fma/fma63261
T368 998-1011 Body_part denotes phospholipids http://purl.org/sig/ont/fma/fma82779
T369 1091-1096 Body_part denotes lungs http://purl.org/sig/ont/fma/fma68877
T370 1147-1160 Body_part denotes phospholipids http://purl.org/sig/ont/fma/fma82779
T371 1299-1307 Body_part denotes monocyte http://purl.org/sig/ont/fma/fma62864
T372 1323-1331 Body_part denotes monocyte http://purl.org/sig/ont/fma/fma62864
T373 1348-1364 Body_part denotes endothelial cell http://purl.org/sig/ont/fma/fma66772
T374 1360-1364 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T375 1393-1405 Body_part denotes phospholipid http://purl.org/sig/ont/fma/fma82779
T376 1520-1524 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T377 1555-1563 Body_part denotes monocyte http://purl.org/sig/ont/fma/fma62864
T378 1564-1574 Body_part denotes macrophage http://purl.org/sig/ont/fma/fma63261

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T55 1520-1524 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T291 789-797 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T292 904-912 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T293 1048-1063 Disease denotes atherosclerosis http://purl.obolibrary.org/obo/MONDO_0005311
T294 1114-1122 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T295 1242-1254 Disease denotes inflammation http://purl.obolibrary.org/obo/MONDO_0021166
T296 1501-1505 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T297 1514-1531 Disease denotes acute lung injury http://purl.obolibrary.org/obo/MONDO_0006502|http://purl.obolibrary.org/obo/MONDO_0015796
T299 1525-1531 Disease denotes injury http://purl.obolibrary.org/obo/MONDO_0021178

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T370 9-17 http://purl.obolibrary.org/obo/CL_0000576 denotes monocyte
T371 38-39 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T372 130-138 http://purl.obolibrary.org/obo/CL_0000576 denotes monocyte
T373 201-209 http://purl.obolibrary.org/obo/CL_0000576 denotes monocyte
T374 214-215 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T375 258-267 http://purl.obolibrary.org/obo/CLO_0001658 denotes activated
T376 268-275 http://purl.obolibrary.org/obo/CL_0000236 denotes B cells
T377 277-286 http://purl.obolibrary.org/obo/SO_0000418 denotes signaling
T378 308-316 http://purl.obolibrary.org/obo/CL_0000576 denotes monocyte
T379 394-398 http://purl.obolibrary.org/obo/CLO_0053704 denotes IL-8
T380 451-459 http://purl.obolibrary.org/obo/CL_0000576 denotes monocyte
T381 508-516 http://purl.obolibrary.org/obo/CL_0000576 denotes monocyte
T382 609-617 http://purl.obolibrary.org/obo/CL_0000576 denotes monocyte
T383 689-698 http://purl.obolibrary.org/obo/CLO_0001658 denotes activated
T384 726-736 http://purl.obolibrary.org/obo/CL_0000234 denotes phagocytic
T385 737-745 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T386 765-766 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T387 1091-1096 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lungs
T388 1299-1307 http://purl.obolibrary.org/obo/CL_0000576 denotes monocyte
T389 1323-1331 http://purl.obolibrary.org/obo/CL_0000576 denotes monocyte
T390 1332-1342 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T391 1348-1364 http://purl.obolibrary.org/obo/CL_0000115 denotes endothelial cell
T392 1365-1375 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T393 1415-1418 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T394 1445-1446 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T395 1483-1484 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T396 1520-1524 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T397 1520-1524 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T398 1535-1536 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T399 1555-1563 http://purl.obolibrary.org/obo/CL_0000576 denotes monocyte
T400 1575-1585 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T401 1616-1617 http://purl.obolibrary.org/obo/CLO_0001021 denotes B

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T177 210-212 Chemical denotes NF http://purl.obolibrary.org/obo/CHEBI_141424|http://purl.obolibrary.org/obo/CHEBI_25573|http://purl.obolibrary.org/obo/CHEBI_1224
T180 317-325 Chemical denotes effector http://purl.obolibrary.org/obo/CHEBI_35224
T181 394-396 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T183 403-406 Chemical denotes MCP http://purl.obolibrary.org/obo/CHEBI_132592|http://purl.obolibrary.org/obo/CHEBI_50099
T185 460-462 Chemical denotes TF http://purl.obolibrary.org/obo/CHEBI_74862
T186 583-585 Chemical denotes PF http://purl.obolibrary.org/obo/CHEBI_74795|http://purl.obolibrary.org/obo/CHEBI_90284
T188 989-1011 Chemical denotes oxidized phospholipids http://purl.obolibrary.org/obo/CHEBI_60156
T189 998-1011 Chemical denotes phospholipids http://purl.obolibrary.org/obo/CHEBI_16247
T190 1131-1136 Chemical denotes OxPLs http://purl.obolibrary.org/obo/CHEBI_60156
T191 1138-1160 Chemical denotes oxidised phospholipids http://purl.obolibrary.org/obo/CHEBI_60156
T192 1147-1160 Chemical denotes phospholipids http://purl.obolibrary.org/obo/CHEBI_16247
T193 1179-1202 Chemical denotes reactive oxygen species http://purl.obolibrary.org/obo/CHEBI_26523
T194 1188-1194 Chemical denotes oxygen http://purl.obolibrary.org/obo/CHEBI_25805
T195 1308-1310 Chemical denotes TF http://purl.obolibrary.org/obo/CHEBI_74862
T196 1384-1405 Chemical denotes oxidized phospholipid http://purl.obolibrary.org/obo/CHEBI_60156
T197 1393-1405 Chemical denotes phospholipid http://purl.obolibrary.org/obo/CHEBI_16247
T198 1612-1614 Chemical denotes NF http://purl.obolibrary.org/obo/CHEBI_141424|http://purl.obolibrary.org/obo/CHEBI_25573|http://purl.obolibrary.org/obo/CHEBI_1224

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T58 1048-1063 Phenotype denotes atherosclerosis http://purl.obolibrary.org/obo/HP_0002621
T59 1514-1531 Phenotype denotes acute lung injury http://www.orpha.net/ORDO/Orphanet_178320

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T110 9-28 http://purl.obolibrary.org/obo/GO_0070487 denotes monocyte aggregates
T111 277-286 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T112 351-360 http://purl.obolibrary.org/obo/GO_0009058 denotes synthesis
T113 1242-1254 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T114 1323-1342 http://purl.obolibrary.org/obo/GO_0042117 denotes monocyte activation
T115 1348-1375 http://purl.obolibrary.org/obo/GO_0042118 denotes endothelial cell activation
T116 1360-1375 http://purl.obolibrary.org/obo/GO_0001775 denotes cell activation
T117 1467-1479 http://purl.obolibrary.org/obo/GO_0009405 denotes pathogenesis
T118 1564-1585 http://purl.obolibrary.org/obo/GO_0042116 denotes macrophage activation

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T124 0-1629 Sentence denotes Platelet-monocyte aggregates may play a role in mechanical occlusion of the microvasculature in addition to altering platelet and monocyte functional responses.110,111 In this regard, platelets induce monocyte NF-κB (nuclear factor κ light-chain-enhancer of activated B cells) signaling and thereby modulate monocyte effector functions and induce the synthesis of the proinflammatory cytokines IL-8 and MCP-1.112 Moreover, platelet P-selectin induces monocyte TF expression and upregulates the expression of monocyte Mac-1 (αMβ2, CD11b/CD18).113,114 The platelet-derived chemokines, PF-4 and CXCL-12, enhance monocyte survival and facilitate differentiation into macrophages,115,116 while activated platelets also enhance the phagocytic activity of macrophages.117 A consistent feature of COVID-19 is the finding that patients with existing cardiovascular risk factors are at an increased risk of severe COVID-19 and have higher fatality rates from the disease.34,35 It is noteworthy that oxidized phospholipids, which are strongly associated with atherosclerosis, have been detected in the lungs of patients with SARS-CoV.118,119 OxPLs (oxidised phospholipids) are generated by reactive oxygen species and play important roles in regulating inflammation given their demonstrated roles in promoting monocyte TF production, monocyte activation, and endothelial cell activation.104 The oxidized phospholipid, oxPAPC, has been demonstrated to play a central role in the pathogenesis of a murine model of SARS-induced acute lung injury in a process linked to monocyte/macrophage activation via the TLR-4-TRIF-TRAF-6-NF-κB pathway.119

2_test

Id Subject Object Predicate Lexical cue
32586214-11994242-21597777 160-163 11994242 denotes 110
32586214-18723438-21597778 164-167 18723438 denotes 111
32586214-18684880-21597779 409-412 18684880 denotes 112
32586214-7522321-21597780 542-545 7522321 denotes 113
32586214-10551687-21597781 546-549 10551687 denotes 114
32586214-26583329-21597782 675-678 26583329 denotes 115
32586214-10666185-21597783 679-682 10666185 denotes 116
32586214-27895175-21597784 761-764 27895175 denotes 117
32586214-32173574-21597785 961-963 32173574 denotes 34
32586214-16000355-21597786 1123-1126 16000355 denotes 118
32586214-18423196-21597787 1127-1130 18423196 denotes 119
32586214-32376901-21597788 1376-1379 32376901 denotes 104
32586214-18423196-21597789 1626-1629 18423196 denotes 119

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
1235 210-215 Gene denotes NF-κB Gene:4790
1236 394-398 Gene denotes IL-8 Gene:3576
1237 403-408 Gene denotes MCP-1 Gene:6347
1238 432-442 Gene denotes P-selectin Gene:6403
1239 460-462 Gene denotes TF Gene:2152
1240 517-522 Gene denotes Mac-1 Gene:3684
1241 530-535 Gene denotes CD11b Gene:3684
1242 536-540 Gene denotes CD18 Gene:3689
1243 583-587 Gene denotes PF-4 Gene:5196
1244 592-599 Gene denotes CXCL-12 Gene:6387
1245 1308-1310 Gene denotes TF Gene:2152
1248 818-826 Species denotes patients Tax:9606
1249 1100-1108 Species denotes patients Tax:9606
1250 1114-1122 Species denotes SARS-CoV Tax:694009
1251 1485-1491 Species denotes murine Tax:10090
1252 998-1011 Chemical denotes phospholipids MESH:D010743
1253 1147-1160 Chemical denotes phospholipids MESH:D010743
1254 1179-1202 Chemical denotes reactive oxygen species MESH:D017382
1262 789-797 Disease denotes COVID-19 MESH:C000657245
1263 904-912 Disease denotes COVID-19 MESH:C000657245
1264 1048-1063 Disease denotes atherosclerosis MESH:D050197
1265 1242-1254 Disease denotes inflammation MESH:D007249
1266 1514-1531 Disease denotes acute lung injury MESH:D055371
1267 1594-1617 Disease denotes TLR-4-TRIF-TRAF-6-NF-κB MESH:C537392