PMC:7386875 / 31784-32796
Annnotations
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T297 | 19-29 | Body_part | denotes | leukocytes | http://purl.org/sig/ont/fma/fma62852 |
| T298 | 108-116 | Body_part | denotes | platelet | http://purl.org/sig/ont/fma/fma62851 |
| T299 | 157-166 | Body_part | denotes | platelets | http://purl.org/sig/ont/fma/fma62851 |
| T300 | 178-189 | Body_part | denotes | neutrophils | http://purl.org/sig/ont/fma/fma62860 |
| T301 | 229-232 | Body_part | denotes | DNA | http://purl.org/sig/ont/fma/fma74412 |
| T302 | 248-259 | Body_part | denotes | neutrophils | http://purl.org/sig/ont/fma/fma62860 |
| T303 | 268-276 | Body_part | denotes | proteins | http://purl.org/sig/ont/fma/fma67257 |
| T304 | 326-336 | Body_part | denotes | neutrophil | http://purl.org/sig/ont/fma/fma62860 |
| T305 | 878-890 | Body_part | denotes | erythrocytes | http://purl.org/sig/ont/fma/fma62845 |
| T306 | 904-913 | Body_part | denotes | platelets | http://purl.org/sig/ont/fma/fma62851 |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T261 | 35-43 | Disease | denotes | thrombus | http://purl.obolibrary.org/obo/MONDO_0000831 |
| T262 | 609-626 | Disease | denotes | venous thrombosis | http://purl.obolibrary.org/obo/MONDO_0008559 |
| T263 | 616-626 | Disease | denotes | thrombosis | http://purl.obolibrary.org/obo/MONDO_0000831 |
| T264 | 676-714 | Disease | denotes | disseminated intravascular coagulation | http://purl.obolibrary.org/obo/MONDO_0001243 |
| T265 | 724-736 | Disease | denotes | preeclampsia | http://purl.obolibrary.org/obo/MONDO_0005081 |
| T266 | 738-748 | Disease | denotes | vasculitis | http://purl.obolibrary.org/obo/MONDO_0018882 |
| T267 | 754-782 | Disease | denotes | systemic lupus erythematosus | http://purl.obolibrary.org/obo/MONDO_0007915 |
| T268 | 763-782 | Disease | denotes | lupus erythematosus | http://purl.obolibrary.org/obo/MONDO_0004670 |
| T269 | 807-817 | Disease | denotes | thrombosis | http://purl.obolibrary.org/obo/MONDO_0000831 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T308 | 33-34 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T309 | 117-127 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activation |
| T310 | 147-156 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | Activated |
| T311 | 217-218 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T312 | 286-289 | http://purl.obolibrary.org/obo/PR_000010543 | denotes | MPO |
| T313 | 291-306 | http://purl.obolibrary.org/obo/PR_000010543 | denotes | myeloperoxidase |
| T314 | 370-371 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T315 | 472-480 | http://purl.obolibrary.org/obo/NCBITaxon_2 | denotes | bacteria |
| T316 | 519-526 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | viruses |
| T317 | 596-604 | http://purl.obolibrary.org/obo/UBERON_0001637 | denotes | arterial |
| T318 | 596-604 | http://www.ebi.ac.uk/efo/EFO_0000814 | denotes | arterial |
| T319 | 642-643 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T320 | 878-890 | http://purl.obolibrary.org/obo/CL_0000232 | denotes | erythrocytes |
| T321 | 895-903 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activate |
| T322 | 941-942 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T323 | 963-972 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activator |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T148 | 229-232 | Chemical | denotes | DNA | http://purl.obolibrary.org/obo/CHEBI_16991 |
| T149 | 268-276 | Chemical | denotes | proteins | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T150 | 309-320 | Chemical | denotes | cathepsin G | http://purl.obolibrary.org/obo/CHEBI_138151 |
LitCovid-PD-HP
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T52 | 609-626 | Phenotype | denotes | venous thrombosis | http://purl.obolibrary.org/obo/HP_0004936 |
| T53 | 676-714 | Phenotype | denotes | disseminated intravascular coagulation | http://purl.obolibrary.org/obo/HP_0005521 |
| T54 | 716-722 | Phenotype | denotes | sepsis | http://purl.obolibrary.org/obo/HP_0100806 |
| T55 | 724-736 | Phenotype | denotes | preeclampsia | http://purl.obolibrary.org/obo/HP_0100602 |
| T56 | 738-748 | Phenotype | denotes | vasculitis | http://purl.obolibrary.org/obo/HP_0002633 |
| T57 | 754-782 | Phenotype | denotes | systemic lupus erythematosus | http://purl.obolibrary.org/obo/HP_0002725 |
LitCovid-PD-GO-BP
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T85 | 62-77 | http://purl.obolibrary.org/obo/GO_0006955 | denotes | immune response |
| T86 | 108-127 | http://purl.obolibrary.org/obo/GO_0030168 | denotes | platelet activation |
| T87 | 132-143 | http://purl.obolibrary.org/obo/GO_0050817 | denotes | coagulation |
| T88 | 506-518 | http://purl.obolibrary.org/obo/GO_0051235 | denotes | sequestering |
| T89 | 580-592 | http://purl.obolibrary.org/obo/GO_0009405 | denotes | pathogenesis |
| T90 | 703-714 | http://purl.obolibrary.org/obo/GO_0050817 | denotes | coagulation |
| T91 | 963-987 | http://purl.obolibrary.org/obo/GO_0050820 | denotes | activator of coagulation |
| T92 | 976-987 | http://purl.obolibrary.org/obo/GO_0050817 | denotes | coagulation |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T112 | 0-1012 | Sentence | denotes | The recruitment of leukocytes to a thrombus not only aids the immune response but also serves to facilitate platelet activation and coagulation.92 Activated platelets facilitate neutrophils to release NETs, which are a matrix of DNA decorated with neutrophils granule proteins, such as MPO (myeloperoxidase), cathepsin G, and neutrophil elastase.93,94 NETs appear to be a primary defence mechanism to invading pathogens and as such have been demonstrated to trap and kill bacteria and fungi in addition to sequestering viruses.94,95 However, NETs have also been implicated in the pathogenesis of arterial and venous thrombosis in addition to a range of pathologies, including disseminated intravascular coagulation, sepsis, preeclampsia, vasculitis, and systemic lupus erythematosus.96,97 In the context of thrombosis, the release of the highly negatively charged NETs can trap erythrocytes and activate platelets.98 Moreover, NETs serve as a scaffold and potent activator of coagulation via multiple mechanisms. |
2_test
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| 32586214-27354721-21597754 | 144-146 | 27354721 | denotes | 92 |
| 32586214-17384648-21597755 | 346-348 | 17384648 | denotes | 93 |
| 32586214-15001782-21597756 | 349-351 | 15001782 | denotes | 94 |
| 32586214-15001782-21597757 | 527-529 | 15001782 | denotes | 94 |
| 32586214-21703402-21597758 | 530-532 | 21703402 | denotes | 95 |
| 32586214-20676107-21597759 | 783-785 | 20676107 | denotes | 96 |
| 32586214-24366358-21597760 | 786-788 | 24366358 | denotes | 97 |
| 32586214-20798043-21597761 | 914-916 | 20798043 | denotes | 98 |
LitCovid-PubTator
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
|---|---|---|---|---|---|
| 1098 | 286-289 | Gene | denotes | MPO | Gene:4353 |
| 1099 | 291-306 | Gene | denotes | myeloperoxidase | Gene:4353 |
| 1100 | 309-320 | Gene | denotes | cathepsin G | Gene:1511 |
| 1106 | 326-345 | Gene | denotes | neutrophil elastase | Gene:1991 |
| 1109 | 35-43 | Disease | denotes | thrombus | MESH:D013927 |
| 1110 | 609-626 | Disease | denotes | venous thrombosis | MESH:D020246 |
| 1111 | 689-714 | Disease | denotes | intravascular coagulation | MESH:D004211 |
| 1112 | 716-722 | Disease | denotes | sepsis | MESH:D018805 |
| 1113 | 738-748 | Disease | denotes | vasculitis | MESH:D014657 |
| 1114 | 754-782 | Disease | denotes | systemic lupus erythematosus | MESH:D008180 |
| 1115 | 807-817 | Disease | denotes | thrombosis | MESH:D013927 |