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PMC:7386875 / 31784-32796 JSONTXT

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LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T297 19-29 Body_part denotes leukocytes http://purl.org/sig/ont/fma/fma62852
T298 108-116 Body_part denotes platelet http://purl.org/sig/ont/fma/fma62851
T299 157-166 Body_part denotes platelets http://purl.org/sig/ont/fma/fma62851
T300 178-189 Body_part denotes neutrophils http://purl.org/sig/ont/fma/fma62860
T301 229-232 Body_part denotes DNA http://purl.org/sig/ont/fma/fma74412
T302 248-259 Body_part denotes neutrophils http://purl.org/sig/ont/fma/fma62860
T303 268-276 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T304 326-336 Body_part denotes neutrophil http://purl.org/sig/ont/fma/fma62860
T305 878-890 Body_part denotes erythrocytes http://purl.org/sig/ont/fma/fma62845
T306 904-913 Body_part denotes platelets http://purl.org/sig/ont/fma/fma62851

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T261 35-43 Disease denotes thrombus http://purl.obolibrary.org/obo/MONDO_0000831
T262 609-626 Disease denotes venous thrombosis http://purl.obolibrary.org/obo/MONDO_0008559
T263 616-626 Disease denotes thrombosis http://purl.obolibrary.org/obo/MONDO_0000831
T264 676-714 Disease denotes disseminated intravascular coagulation http://purl.obolibrary.org/obo/MONDO_0001243
T265 724-736 Disease denotes preeclampsia http://purl.obolibrary.org/obo/MONDO_0005081
T266 738-748 Disease denotes vasculitis http://purl.obolibrary.org/obo/MONDO_0018882
T267 754-782 Disease denotes systemic lupus erythematosus http://purl.obolibrary.org/obo/MONDO_0007915
T268 763-782 Disease denotes lupus erythematosus http://purl.obolibrary.org/obo/MONDO_0004670
T269 807-817 Disease denotes thrombosis http://purl.obolibrary.org/obo/MONDO_0000831

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T308 33-34 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T309 117-127 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T310 147-156 http://purl.obolibrary.org/obo/CLO_0001658 denotes Activated
T311 217-218 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T312 286-289 http://purl.obolibrary.org/obo/PR_000010543 denotes MPO
T313 291-306 http://purl.obolibrary.org/obo/PR_000010543 denotes myeloperoxidase
T314 370-371 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T315 472-480 http://purl.obolibrary.org/obo/NCBITaxon_2 denotes bacteria
T316 519-526 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T317 596-604 http://purl.obolibrary.org/obo/UBERON_0001637 denotes arterial
T318 596-604 http://www.ebi.ac.uk/efo/EFO_0000814 denotes arterial
T319 642-643 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T320 878-890 http://purl.obolibrary.org/obo/CL_0000232 denotes erythrocytes
T321 895-903 http://purl.obolibrary.org/obo/CLO_0001658 denotes activate
T322 941-942 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T323 963-972 http://purl.obolibrary.org/obo/CLO_0001658 denotes activator

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T148 229-232 Chemical denotes DNA http://purl.obolibrary.org/obo/CHEBI_16991
T149 268-276 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T150 309-320 Chemical denotes cathepsin G http://purl.obolibrary.org/obo/CHEBI_138151

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T52 609-626 Phenotype denotes venous thrombosis http://purl.obolibrary.org/obo/HP_0004936
T53 676-714 Phenotype denotes disseminated intravascular coagulation http://purl.obolibrary.org/obo/HP_0005521
T54 716-722 Phenotype denotes sepsis http://purl.obolibrary.org/obo/HP_0100806
T55 724-736 Phenotype denotes preeclampsia http://purl.obolibrary.org/obo/HP_0100602
T56 738-748 Phenotype denotes vasculitis http://purl.obolibrary.org/obo/HP_0002633
T57 754-782 Phenotype denotes systemic lupus erythematosus http://purl.obolibrary.org/obo/HP_0002725

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T85 62-77 http://purl.obolibrary.org/obo/GO_0006955 denotes immune response
T86 108-127 http://purl.obolibrary.org/obo/GO_0030168 denotes platelet activation
T87 132-143 http://purl.obolibrary.org/obo/GO_0050817 denotes coagulation
T88 506-518 http://purl.obolibrary.org/obo/GO_0051235 denotes sequestering
T89 580-592 http://purl.obolibrary.org/obo/GO_0009405 denotes pathogenesis
T90 703-714 http://purl.obolibrary.org/obo/GO_0050817 denotes coagulation
T91 963-987 http://purl.obolibrary.org/obo/GO_0050820 denotes activator of coagulation
T92 976-987 http://purl.obolibrary.org/obo/GO_0050817 denotes coagulation

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T112 0-1012 Sentence denotes The recruitment of leukocytes to a thrombus not only aids the immune response but also serves to facilitate platelet activation and coagulation.92 Activated platelets facilitate neutrophils to release NETs, which are a matrix of DNA decorated with neutrophils granule proteins, such as MPO (myeloperoxidase), cathepsin G, and neutrophil elastase.93,94 NETs appear to be a primary defence mechanism to invading pathogens and as such have been demonstrated to trap and kill bacteria and fungi in addition to sequestering viruses.94,95 However, NETs have also been implicated in the pathogenesis of arterial and venous thrombosis in addition to a range of pathologies, including disseminated intravascular coagulation, sepsis, preeclampsia, vasculitis, and systemic lupus erythematosus.96,97 In the context of thrombosis, the release of the highly negatively charged NETs can trap erythrocytes and activate platelets.98 Moreover, NETs serve as a scaffold and potent activator of coagulation via multiple mechanisms.

2_test

Id Subject Object Predicate Lexical cue
32586214-27354721-21597754 144-146 27354721 denotes 92
32586214-17384648-21597755 346-348 17384648 denotes 93
32586214-15001782-21597756 349-351 15001782 denotes 94
32586214-15001782-21597757 527-529 15001782 denotes 94
32586214-21703402-21597758 530-532 21703402 denotes 95
32586214-20676107-21597759 783-785 20676107 denotes 96
32586214-24366358-21597760 786-788 24366358 denotes 97
32586214-20798043-21597761 914-916 20798043 denotes 98

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
1098 286-289 Gene denotes MPO Gene:4353
1099 291-306 Gene denotes myeloperoxidase Gene:4353
1100 309-320 Gene denotes cathepsin G Gene:1511
1106 326-345 Gene denotes neutrophil elastase Gene:1991
1109 35-43 Disease denotes thrombus MESH:D013927
1110 609-626 Disease denotes venous thrombosis MESH:D020246
1111 689-714 Disease denotes intravascular coagulation MESH:D004211
1112 716-722 Disease denotes sepsis MESH:D018805
1113 738-748 Disease denotes vasculitis MESH:D014657
1114 754-782 Disease denotes systemic lupus erythematosus MESH:D008180
1115 807-817 Disease denotes thrombosis MESH:D013927