PMC:7386875 / 20964-21883 JSON TXT

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Id	Subject	Object	Predicate	Lexical cue	fma_id
T148	94-109	Body_part	denotes	(interleukin)-6	http://purl.org/sig/ont/fma/fma264829
T149	95-106	Body_part	denotes	interleukin	http://purl.org/sig/ont/fma/fma86578
T150	111-115	Body_part	denotes	IL-1	http://purl.org/sig/ont/fma/fma86583
T151	145-153	Body_part	denotes	monocyte	http://purl.org/sig/ont/fma/fma62864
T152	170-177	Body_part	denotes	protein	http://purl.org/sig/ont/fma/fma67257
T153	187-197	Body_part	denotes	macrophage	http://purl.org/sig/ont/fma/fma63261
T154	211-218	Body_part	denotes	protein	http://purl.org/sig/ont/fma/fma67257
T155	264-273	Body_part	denotes	cytokines	http://purl.org/sig/ont/fma/fma84050
T156	396-400	Body_part	denotes	ICAM	http://purl.org/sig/ont/fma/fma67857
T157	438-446	Body_part	denotes	integrin	http://purl.org/sig/ont/fma/fma67222
T158	460-470	Body_part	denotes	E-selectin	http://purl.org/sig/ont/fma/fma62932
T159	506-515	Body_part	denotes	cytokines	http://purl.org/sig/ont/fma/fma84050
T160	520-530	Body_part	denotes	chemokines	http://purl.org/sig/ont/fma/fma241981
T161	547-558	Body_part	denotes	endothelium	http://purl.org/sig/ont/fma/fma63916
T162	644-653	Body_part	denotes	platelets	http://purl.org/sig/ont/fma/fma62851
T163	658-668	Body_part	denotes	leukocytes	http://purl.org/sig/ont/fma/fma62852
T164	817-823	Body_part	denotes	tissue	http://purl.org/sig/ont/fma/fma9637

Id	Subject	Object	Predicate	Lexical cue	uberon_id
T40	547-558	Body_part	denotes	endothelium	http://purl.obolibrary.org/obo/UBERON_0001986
T41	817-823	Body_part	denotes	tissue	http://purl.obolibrary.org/obo/UBERON_0000479

Id	Subject	Object	Predicate	Lexical cue	mondo_id
T195	29-37	Disease	denotes	SARS-CoV	http://purl.obolibrary.org/obo/MONDO_0005091
T196	890-898	Disease	denotes	COVID-19	http://purl.obolibrary.org/obo/MONDO_0100096

Id	Subject	Object	Predicate	Lexical cue
T193	94-109	http://purl.obolibrary.org/obo/PR_000001393	denotes	(interleukin)-6
T194	145-153	http://purl.obolibrary.org/obo/CL_0000576	denotes	monocyte
T195	239-241	http://purl.obolibrary.org/obo/CLO_0053733	denotes	11
T196	547-558	http://purl.obolibrary.org/obo/UBERON_0001986	denotes	endothelium
T197	566-567	http://purl.obolibrary.org/obo/CLO_0001020	denotes	a
T198	856-857	http://purl.obolibrary.org/obo/CLO_0001020	denotes	a

Id	Subject	Object	Predicate	Lexical cue	chebi_id
T99	91-93	Chemical	denotes	IL	http://purl.obolibrary.org/obo/CHEBI_63895\|http://purl.obolibrary.org/obo/CHEBI_74072
T101	111-113	Chemical	denotes	IL	http://purl.obolibrary.org/obo/CHEBI_63895\|http://purl.obolibrary.org/obo/CHEBI_74072
T103	123-133	Chemical	denotes	interferon	http://purl.obolibrary.org/obo/CHEBI_52999
T104	138-141	Chemical	denotes	MCP	http://purl.obolibrary.org/obo/CHEBI_132592\|http://purl.obolibrary.org/obo/CHEBI_50099
T106	170-177	Chemical	denotes	protein	http://purl.obolibrary.org/obo/CHEBI_36080
T107	211-218	Chemical	denotes	protein	http://purl.obolibrary.org/obo/CHEBI_36080
T108	231-237	Chemical	denotes	CXCL10	http://purl.obolibrary.org/obo/CHEBI_138157
T109	377-386	Chemical	denotes	molecules	http://purl.obolibrary.org/obo/CHEBI_25367
T110	425-433	Chemical	denotes	molecule	http://purl.obolibrary.org/obo/CHEBI_25367
T111	756-770	Chemical	denotes	anticoagulants	http://purl.obolibrary.org/obo/CHEBI_50249
T112	832-834	Chemical	denotes	TF	http://purl.obolibrary.org/obo/CHEBI_74862

Id	Subject	Object	Predicate	Lexical cue	hp_id
T39	911-918	Phenotype	denotes	hypoxia	http://purl.obolibrary.org/obo/HP_0012418

Id	Subject	Object	Predicate	Lexical cue
T84	0-919	Sentence	denotes	Interestingly, patients with SARS-CoV-2 have been demonstrated to have increased levels of IL (interleukin)-6, IL-1β, IFN (interferon)-γ, MCP-1 (monocyte chemoattractant protein 1), MIP (macrophage inflammatory protein), and IP10 (CXCL10).11 These proinflammatory cytokines can disrupt endothelial function and integrity leading to the release of VWF, upregulation of adhesion molecules, such as ICAM (intercellular adhesion molecule)-1, integrin αvβ3, P- and E-selectin, and the production of endothelial cytokines and chemokines.56,57 Thus, the endothelium adopts a proinflammatory and procoagulant phenotype that supports the recruitment of platelets and leukocytes.58,59 Furthermore, these changes are associated with the downregulation of the natural anticoagulants and corresponding upregulation of endothelial tissue factor (TF, CD142).57 Moreover, a common finding in patients with COVID-19 is profound hypoxia.

Id	Subject	Object	Predicate	Lexical cue
32586214-31986264-21597711	239-241	31986264	denotes	11
32586214-9517590-21597712	531-533	9517590	denotes	56
32586214-12543869-21597713	534-536	12543869	denotes	57
32586214-9657750-21597714	669-671	9657750	denotes	58
32586214-7507411-21597715	672-674	7507411	denotes	59
32586214-12543869-21597716	843-845	12543869	denotes	57

Id	Subject	Object	Predicate	Lexical cue	tao:has_database_id
790	91-109	Gene	denotes	IL (interleukin)-6	Gene:3569
791	111-116	Gene	denotes	IL-1β	Gene:3552
792	118-121	Gene	denotes	IFN	Gene:3439
793	123-136	Gene	denotes	interferon)-γ	Gene:3458
794	138-143	Gene	denotes	MCP-1	Gene:6347
795	145-179	Gene	denotes	monocyte chemoattractant protein 1	Gene:6347
796	225-229	Gene	denotes	IP10	Gene:3627
797	231-237	Gene	denotes	CXCL10	Gene:3627
798	347-350	Gene	denotes	VWF	Gene:7450
799	402-436	Gene	denotes	intercellular adhesion molecule)-1	Gene:3383
800	438-451	Gene	denotes	integrin αvβ3	Gene:3685
801	460-470	Gene	denotes	E-selectin	Gene:6401
802	832-834	Gene	denotes	TF	Gene:2152
803	836-841	Gene	denotes	CD142	Gene:2152
806	15-23	Species	denotes	patients	Tax:9606
807	29-39	Species	denotes	SARS-CoV-2	Tax:2697049
808	876-884	Species	denotes	patients	Tax:9606
809	182-185	Gene	denotes	MIP	Gene:4284
810	817-830	Gene	denotes	tissue factor	Gene:2152
811	890-898	Disease	denotes	COVID-19	MESH:C000657245
812	911-918	Disease	denotes	hypoxia	MESH:D000860