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PMC:7386875 / 10418-12485 JSONTXT

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LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T53 69-80 Body_part denotes endothelium http://purl.org/sig/ont/fma/fma63916
T54 255-261 Body_part denotes tissue http://purl.org/sig/ont/fma/fma9637
T55 299-306 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T56 375-392 Body_part denotes endothelial cells http://purl.org/sig/ont/fma/fma66772
T57 387-392 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T58 427-448 Body_part denotes von Willebrand factor http://purl.org/sig/ont/fma/fma81101
T59 481-485 Body_part denotes ICAM http://purl.org/sig/ont/fma/fma67857
T60 529-539 Body_part denotes P-selectin http://purl.org/sig/ont/fma/fma62933
T61 544-554 Body_part denotes E-selectin http://purl.org/sig/ont/fma/fma62932
T62 582-592 Body_part denotes leukocytes http://purl.org/sig/ont/fma/fma62852
T63 597-606 Body_part denotes platelets http://purl.org/sig/ont/fma/fma62851
T64 618-627 Body_part denotes platelets http://purl.org/sig/ont/fma/fma62851
T65 636-646 Body_part denotes chemokines http://purl.org/sig/ont/fma/fma241981
T66 658-666 Body_part denotes platelet http://purl.org/sig/ont/fma/fma62851
T67 740-744 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T68 790-799 Body_part denotes leukocyte http://purl.org/sig/ont/fma/fma62852
T69 813-823 Body_part denotes Leukocytes http://purl.org/sig/ont/fma/fma62852
T70 838-847 Body_part denotes platelets http://purl.org/sig/ont/fma/fma62851
T71 897-905 Body_part denotes platelet http://purl.org/sig/ont/fma/fma62851
T72 906-916 Body_part denotes P-selectin http://purl.org/sig/ont/fma/fma62933
T73 955-965 Body_part denotes P-selectin http://purl.org/sig/ont/fma/fma62933
T74 966-978 Body_part denotes glycoprotein http://purl.org/sig/ont/fma/fma62925
T75 985-995 Body_part denotes leukocytes http://purl.org/sig/ont/fma/fma62852
T76 1006-1015 Body_part denotes platelets http://purl.org/sig/ont/fma/fma62851
T77 1042-1051 Body_part denotes monocytes http://purl.org/sig/ont/fma/fma62864
T78 1056-1067 Body_part denotes neutrophils http://purl.org/sig/ont/fma/fma62860
T79 1112-1123 Body_part denotes neutrophils http://purl.org/sig/ont/fma/fma62860
T80 1135-1144 Body_part denotes platelets http://purl.org/sig/ont/fma/fma62851
T81 1266-1274 Body_part denotes monocyte http://purl.org/sig/ont/fma/fma62864
T82 1291-1299 Body_part denotes monocyte http://purl.org/sig/ont/fma/fma62864
T83 1300-1306 Body_part denotes tissue http://purl.org/sig/ont/fma/fma9637
T84 1411-1422 Body_part denotes Neutrophils http://purl.org/sig/ont/fma/fma62860
T85 1431-1441 Body_part denotes neutrophil http://purl.org/sig/ont/fma/fma62860
T86 1566-1575 Body_part denotes platelets http://purl.org/sig/ont/fma/fma62851
T87 1636-1646 Body_part denotes leukocytes http://purl.org/sig/ont/fma/fma62852
T88 1688-1696 Body_part denotes platelet http://purl.org/sig/ont/fma/fma62851
T89 1766-1775 Body_part denotes cytokines http://purl.org/sig/ont/fma/fma84050
T90 1790-1805 Body_part denotes (interleukin)-1 http://purl.org/sig/ont/fma/fma86583
T91 1791-1802 Body_part denotes interleukin http://purl.org/sig/ont/fma/fma86578
T92 1828-1836 Body_part denotes monocyte http://purl.org/sig/ont/fma/fma62864
T93 1853-1860 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T94 1956-1965 Body_part denotes platelets http://purl.org/sig/ont/fma/fma62851
T95 1967-1977 Body_part denotes leukocytes http://purl.org/sig/ont/fma/fma62852
T96 1983-1994 Body_part denotes endothelium http://purl.org/sig/ont/fma/fma63916

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T11 69-80 Body_part denotes endothelium http://purl.obolibrary.org/obo/UBERON_0001986
T12 255-261 Body_part denotes tissue http://purl.obolibrary.org/obo/UBERON_0000479
T13 1300-1306 Body_part denotes tissue http://purl.obolibrary.org/obo/UBERON_0000479
T14 1983-1994 Body_part denotes endothelium http://purl.obolibrary.org/obo/UBERON_0001986

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T109 348-357 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T110 361-373 Disease denotes inflammation http://purl.obolibrary.org/obo/MONDO_0021166
T111 1168-1173 Disease denotes polyP http://purl.obolibrary.org/obo/MONDO_0005079
T112 1483-1493 Disease denotes thrombosis http://purl.obolibrary.org/obo/MONDO_0000831

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T82 69-80 http://purl.obolibrary.org/obo/UBERON_0001986 denotes endothelium
T83 289-298 http://purl.obolibrary.org/obo/CLO_0001658 denotes activated
T84 375-392 http://purl.obolibrary.org/obo/CL_0000115 denotes endothelial cells
T85 608-617 http://purl.obolibrary.org/obo/CLO_0001658 denotes Activated
T86 719-729 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T87 738-744 http://purl.obolibrary.org/obo/CL_0000084 denotes T-cell
T88 1042-1051 http://purl.obolibrary.org/obo/CL_0000576 denotes monocytes
T89 1125-1134 http://purl.obolibrary.org/obo/CLO_0001658 denotes Activated
T90 1182-1191 http://purl.obolibrary.org/obo/CLO_0001658 denotes activates
T91 1266-1274 http://purl.obolibrary.org/obo/CL_0000576 denotes monocyte
T92 1291-1299 http://purl.obolibrary.org/obo/CL_0000576 denotes monocyte
T93 1498-1508 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T94 1552-1562 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T95 1597-1607 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T96 1697-1707 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T97 1790-1805 http://purl.obolibrary.org/obo/PR_000001091 denotes (interleukin)-1
T98 1813-1817 http://purl.obolibrary.org/obo/CLO_0053704 denotes IL-8
T99 1828-1836 http://purl.obolibrary.org/obo/CL_0000576 denotes monocyte
T100 1942-1952 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T101 1983-1994 http://purl.obolibrary.org/obo/UBERON_0001986 denotes endothelium
T102 2014-2023 http://purl.obolibrary.org/obo/CLO_0001658 denotes activated
T103 2053-2054 http://purl.obolibrary.org/obo/CLO_0001020 denotes a

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T45 170-182 Chemical denotes nitric oxide http://purl.obolibrary.org/obo/CHEBI_16480
T46 177-182 Chemical denotes oxide http://purl.obolibrary.org/obo/CHEBI_25741|http://purl.obolibrary.org/obo/CHEBI_29356
T48 233-247 Chemical denotes anticoagulants http://purl.obolibrary.org/obo/CHEBI_50249
T49 269-286 Chemical denotes pathway inhibitor http://purl.obolibrary.org/obo/CHEBI_76932
T50 277-286 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T51 299-306 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T52 463-472 Chemical denotes molecules http://purl.obolibrary.org/obo/CHEBI_25367
T53 510-518 Chemical denotes molecule http://purl.obolibrary.org/obo/CHEBI_25367
T54 654-656 Chemical denotes PF http://purl.obolibrary.org/obo/CHEBI_74795|http://purl.obolibrary.org/obo/CHEBI_90284
T56 678-683 Chemical denotes CXCL5 http://purl.obolibrary.org/obo/CHEBI_138180
T57 685-690 Chemical denotes CXCL7 http://purl.obolibrary.org/obo/CHEBI_138155
T58 774-778 Chemical denotes CCL7 http://purl.obolibrary.org/obo/CHEBI_138183
T59 869-875 Chemical denotes ligand http://purl.obolibrary.org/obo/CHEBI_52214
T60 966-978 Chemical denotes glycoprotein http://purl.obolibrary.org/obo/CHEBI_17089
T61 997-999 Chemical denotes GP http://purl.obolibrary.org/obo/CHEBI_70744
T62 1153-1166 Chemical denotes polyphosphate http://purl.obolibrary.org/obo/CHEBI_16838
T63 1168-1173 Chemical denotes polyP http://purl.obolibrary.org/obo/CHEBI_16838
T64 1237-1242 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T65 1315-1317 Chemical denotes TF http://purl.obolibrary.org/obo/CHEBI_74862
T66 1384-1386 Chemical denotes TF http://purl.obolibrary.org/obo/CHEBI_74862
T67 1663-1665 Chemical denotes TF http://purl.obolibrary.org/obo/CHEBI_74862
T68 1787-1789 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T70 1807-1809 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T72 1813-1815 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T74 1823-1826 Chemical denotes MCP http://purl.obolibrary.org/obo/CHEBI_132592|http://purl.obolibrary.org/obo/CHEBI_50099
T76 1853-1860 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T28 52-63 http://purl.obolibrary.org/obo/GO_0042592 denotes homeostasis
T29 361-373 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T30 1398-1409 http://purl.obolibrary.org/obo/GO_0050817 denotes coagulation
T31 1586-1607 http://purl.obolibrary.org/obo/GO_0006956 denotes complement activation
T32 1688-1707 http://purl.obolibrary.org/obo/GO_0030168 denotes platelet activation

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T49 0-39 Sentence denotes Mechanisms regulating immunothrombosis.
T50 40-329 Sentence denotes In vascular homeostasis, the endothelium possesses anti-inflammatory and antithrombotic properties due to the expression of CD39, nitric oxide (NO), and prostacyclin in addition to the natural anticoagulants, TFPI (tissue factor pathway inhibitor), activated protein C, and thrombomodulin.
T51 330-607 Sentence denotes In the setting of infection or inflammation, endothelial cells upregulate the expression of VWF (von Willebrand factor) and adhesion molecules such as ICAM (intercellular adhesion molecule)-1, αvβ3, P-selectin and E-selectin, promoting the adhesion of leukocytes and platelets.
T52 608-812 Sentence denotes Activated platelets release chemokines CXCL1, PF (platelet factor)-4, CXCL5, CXCL7, CCL3, RANTES (regulated on activation, normal T-cell expressed and secreted), and CCL7 to enhance leukocyte recruitment.
T53 813-882 Sentence denotes Leukocytes interact with platelets via several receptor/ligand pairs.
T54 883-1124 Sentence denotes These include platelet P-selectin binding to its cognate receptor PSGL (P-selectin glycoprotein)-1 on leukocytes, GP-Ib on platelets interacting with Mac-1 on monocytes and neutrophils, and GPIIb/IIIa binding to SLC44A2/CTL-2 on neutrophils.
T55 1125-1410 Sentence denotes Activated platelets release polyphosphate (polyP), which activates the contact pathway, and HMGB (high mobility group box)-1, which enhances monocyte recruitment and monocyte tissue factor (TF) expression, thereby amplifying thrombin generation by way of the TF pathway of coagulation.
T56 1411-1576 Sentence denotes Neutrophils release neutrophil extracellular traps (NETs) which promote thrombosis via activation of the contact pathway and the binding and activation of platelets.
T57 1577-1864 Sentence denotes Finally, complement activation leads to the recruitment of leukocytes and upregulates TF expression, amplifies platelet activation and upregulates endothelial expression of proinflammatory cytokines, including IL (interleukin)-1, IL-6, IL-8, and MCP (monocyte chemoattractant protein)-1.
T58 1865-2067 Sentence denotes These mechanisms result in excess thrombin generation, which potentiates the activation of platelets, leukocytes, and endothelium via PARs (protease-activated receptors) and culminates in a fibrin clot.

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
440 164-168 Gene denotes CD39 Gene:953
441 249-253 Gene denotes TFPI Gene:7035
442 255-286 Gene denotes tissue factor pathway inhibitor Gene:7035
443 314-328 Gene denotes thrombomodulin Gene:7056
444 422-425 Gene denotes VWF Gene:7450
445 427-448 Gene denotes von Willebrand factor Gene:7450
446 487-521 Gene denotes intercellular adhesion molecule)-1 Gene:3383
447 529-539 Gene denotes P-selectin Gene:6403
448 544-554 Gene denotes E-selectin Gene:6401
449 647-652 Gene denotes CXCL1 Gene:2919
450 654-676 Gene denotes PF (platelet factor)-4 Gene:5196
451 678-683 Gene denotes CXCL5 Gene:6374
452 685-690 Gene denotes CXCL7 Gene:5473
453 692-696 Gene denotes CCL3 Gene:6348
454 698-704 Gene denotes RANTES Gene:6352
455 774-778 Gene denotes CCL7 Gene:6354
456 906-916 Gene denotes P-selectin Gene:6403
457 1033-1038 Gene denotes Mac-1 Gene:3684
458 1073-1078 Gene denotes GPIIb Gene:3674
459 1095-1102 Gene denotes SLC44A2 Gene:57153
460 1103-1108 Gene denotes CTL-2 Gene:57153
461 1217-1221 Gene denotes HMGB Gene:6749
462 1223-1249 Gene denotes high mobility group box)-1 Gene:3146
463 1300-1313 Gene denotes tissue factor Gene:2152
464 1350-1358 Gene denotes thrombin Gene:2147
465 1663-1665 Gene denotes TF Gene:2152
466 1787-1805 Gene denotes IL (interleukin)-1 Gene:3552
467 1807-1811 Gene denotes IL-6 Gene:3569
468 1813-1817 Gene denotes IL-8 Gene:3576
469 1823-1826 Gene denotes MCP Gene:4179
470 1828-1863 Gene denotes monocyte chemoattractant protein)-1 Gene:6347
471 1899-1907 Gene denotes thrombin Gene:2147
472 1384-1386 Gene denotes TF Gene:2152
473 1315-1317 Gene denotes TF Gene:2152
474 170-182 Chemical denotes nitric oxide MESH:D009569
475 193-205 Chemical denotes prostacyclin MESH:D011464
476 1153-1166 Chemical denotes polyphosphate MESH:D011122
477 1168-1173 Chemical denotes polyP MESH:D011122
478 22-38 Disease denotes immunothrombosis
479 348-357 Disease denotes infection MESH:D007239
480 361-373 Disease denotes inflammation MESH:D007249
481 1483-1493 Disease denotes thrombosis MESH:D013927