PMC:7386785 / 90674-94838 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7386785","sourcedb":"PMC","sourceid":"7386785","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7386785","text":"Study characteristics\nPatient Sampling Purpose: to identify the clinical features and CT manifestations of COVID‐19 and compare them with those of pneumonia occurring in patients who do not have COVID‐19Design: cross‐sectional single‐centre retrospective studyRecruitment: pneumonia patients who presented at a fever observation department in ShanghaiSample size: n = 33 (11 cases)Inclusion criteria: patients with clinical and radiological features of pneumonia, and a normal or reduced total leukocyte count or total lymphocyte count, plus an epidemiologic history that included travel or a history of residence in Hubei province or other areas where continuous transmission of local cases occurred within 14 days before onset of symptoms, a history of contact with patients who had fever or respiratory symptoms and were from Hubei province or other areas with continuous transmission of local cases within 14 days before onset of the disease, or clustering or epidemiologic association with the new coronavirus infectionExclusion criteria: not defined\nPatient characteristics and setting Facility cases: confirmed case: positive RT‐PCR test result obtained by a throat swab. Test was repeated when the first test was negativeFacility controls: pneumonia patients confirmed not to be infected by SARS‐Cov2 (2 PCR tests)Country: ChinaDates: 19 January 2020‐6 February 2020Symptoms and severity: pneumonia was defined as patients with at least 1 clinical symptom (i.e. cough, sputum, fever, dyspnoea, or pleuritic chest pain), a finding of either coarse crackles on auscultation or elevated inflammatory biomarkers, and observation of a new pulmonary opacification on chest CTDemographics: median age +‐ SD cases 50.36 +‐ 15.5, controls 43.59 +‐ 16.02, gender distribution cases (M/F: 8/3), controls (M/F: 7/15)Exposure history: cases 8/11, controls 7/22 (in the last 14 days with patients with fever or respiratory symptoms or with known cases)\nIndex tests Fever\nCough\nSputum\nShortness of breath\nMuscle ache\nDiarrhoea\nSore throat\nPeak body temperature\nTarget condition and reference standard(s) TC: COVID‐19 pneumonia\nRS: RT‐PCR testing on throat swab specimens\nTests were repeated if the first test was negative\nFlow and timing Time interval not specified, reference test at day 0 (or later when the first test was negative), index tests were questionnaired at day 0 for the presence of symptoms in the past period of time\nComparative  \nNotes  \nMethodological quality\nItem Authors' judgement Risk of bias Applicability concerns\nDOMAIN 1: Patient Selection\nWas a consecutive or random sample of patients enrolled? Unclear    \nWas a case‐control design avoided? Yes    \nDid the study avoid inappropriate exclusions? Unclear    \nDid the study avoid inappropriate inclusions? No    \nCould the selection of patients have introduced bias?   High risk  \nAre there concerns that the included patients and setting do not match the review question?     High\nDOMAIN 2: Index Test (All tests)\nWere the index test results interpreted without knowledge of the results of the reference standard? Yes    \nIf a threshold was used, was it pre‐specified? No    \nCould the conduct or interpretation of the index test have introduced bias?   High risk  \nAre there concerns that the index test, its conduct, or interpretation differ from the review question?     Low concern\nDOMAIN 3: Reference Standard\nIs the reference standards likely to correctly classify the target condition? Yes    \nWere the reference standard results interpreted without knowledge of the results of the index tests? Unclear    \nCould the reference standard, its conduct, or its interpretation have introduced bias?   Low risk  \nAre there concerns that the target condition as defined by the reference standard does not match the question?     Low concern\nDOMAIN 4: Flow and Timing\nWas there an appropriate interval between index test and reference standard? Unclear    \nDid all patients receive the same reference standard? Yes    \nWere all patients included in the analysis? Yes    \nCould the patient flow have introduced bias?   Low risk 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