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PMC:7381711 / 19940-21053 JSONTXT

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LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T174 44-51 Body_part denotes heparin http://purl.org/sig/ont/fma/fma82839
T175 95-104 Body_part denotes Heparin’s http://purl.org/sig/ont/fma/fma82839
T176 414-430 Body_part denotes epithelial cells http://purl.org/sig/ont/fma/fma66768
T177 425-430 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T178 483-495 Body_part denotes cell surface http://purl.org/sig/ont/fma/fma67653
T179 483-487 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T180 496-511 Body_part denotes heparan sulfate http://purl.org/sig/ont/fma/fma63023
T181 519-526 Body_part denotes heparin http://purl.org/sig/ont/fma/fma82839
T182 560-567 Body_part denotes heparin http://purl.org/sig/ont/fma/fma82839
T183 641-648 Body_part denotes heparin http://purl.org/sig/ont/fma/fma82839
T184 847-854 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T185 858-860 Body_part denotes HS http://purl.org/sig/ont/fma/fma63023
T186 862-877 Body_part denotes heparan sulfate http://purl.org/sig/ont/fma/fma63023
T187 879-881 Body_part denotes IL http://purl.org/sig/ont/fma/fma86578
T188 883-894 Body_part denotes interleukin http://purl.org/sig/ont/fma/fma86578
T189 942-948 Body_part denotes tissue http://purl.org/sig/ont/fma/fma9637
T190 963-969 Body_part denotes tissue http://purl.org/sig/ont/fma/fma9637
T191 1029-1035 Body_part denotes tissue http://purl.org/sig/ont/fma/fma9637

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T21 942-948 Body_part denotes tissue http://purl.obolibrary.org/obo/UBERON_0000479
T22 963-969 Body_part denotes tissue http://purl.obolibrary.org/obo/UBERON_0000479
T23 1029-1035 Body_part denotes tissue http://purl.obolibrary.org/obo/UBERON_0000479

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
708 172-188 Gene denotes antithrombin-III Gene:462
709 190-193 Gene denotes AT3 Gene:462
710 793-797 Gene denotes ACE2 Gene:59272
711 799-830 Gene denotes angiotensin-converting enzyme 2 Gene:59272
712 832-835 Gene denotes APC Gene:324
713 896-901 Gene denotes PAI-1 Gene:5054
714 903-936 Gene denotes plasminogen activator inhibitor 1 Gene:5054
715 957-961 Gene denotes TFPI Gene:7035
716 963-994 Gene denotes tissue factor pathway inhibitor Gene:7035
717 996-999 Gene denotes TNF Gene:7124
718 1059-1062 Gene denotes uPA Gene:5328
719 942-955 Gene denotes tissue factor Gene:2152
720 1029-1057 Gene denotes tissue plasminogen activator Gene:100128998
721 321-368 Species denotes Severe acute respiratory syndrome coronavirus 2 Tax:2697049
722 370-380 Species denotes SARS-CoV-2 Tax:2697049
723 44-51 Chemical denotes heparin MESH:D006493
724 95-102 Chemical denotes Heparin MESH:D006493
725 496-511 Chemical denotes heparan sulfate MESH:D006497
726 519-526 Chemical denotes heparin MESH:D006493
727 560-567 Chemical denotes heparin MESH:D006493
728 641-648 Chemical denotes heparin MESH:D006493
729 862-877 Chemical denotes heparan sulfate MESH:D006497
730 55-79 Disease denotes coronavirus disease 2019 MESH:C000657245
731 81-89 Disease denotes COVID-19 MESH:C000657245
732 251-263 Disease denotes coagulopathy MESH:D001778
733 291-301 Disease denotes thrombosis MESH:D013927
734 712-720 Disease denotes COVID-19 MESH:C000657245
735 1001-1015 Disease denotes tumor necrosis MESH:D009336

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T166 55-79 Disease denotes coronavirus disease 2019 http://purl.obolibrary.org/obo/MONDO_0100096
T167 81-89 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T168 251-263 Disease denotes coagulopathy http://purl.obolibrary.org/obo/MONDO_0001531
T169 291-301 Disease denotes thrombosis http://purl.obolibrary.org/obo/MONDO_0000831
T170 321-368 Disease denotes Severe acute respiratory syndrome coronavirus 2 http://purl.obolibrary.org/obo/MONDO_0100096
T171 370-378 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T172 370-374 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T173 712-720 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T174 1001-1006 Disease denotes tumor http://purl.obolibrary.org/obo/MONDO_0005070
T175 1059-1062 Disease denotes uPA http://purl.obolibrary.org/obo/MONDO_0004041

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T142 414-424 http://purl.obolibrary.org/obo/CL_0000066 denotes epithelial
T143 425-430 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T144 483-487 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T145 649-652 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T146 837-846 http://purl.obolibrary.org/obo/CLO_0001658 denotes activated
T147 903-914 http://purl.obolibrary.org/obo/PR_000012867 denotes plasminogen
T148 915-924 http://purl.obolibrary.org/obo/CLO_0001658 denotes activator
T149 1024-1027 http://purl.obolibrary.org/obo/CLO_0053275 denotes tPA
T150 1024-1027 http://purl.obolibrary.org/obo/CLO_0053276 denotes tPA
T151 1024-1027 http://purl.obolibrary.org/obo/CLO_0053277 denotes tPA
T152 1036-1047 http://purl.obolibrary.org/obo/PR_000012867 denotes plasminogen
T153 1048-1057 http://purl.obolibrary.org/obo/CLO_0001658 denotes activator
T154 1074-1085 http://purl.obolibrary.org/obo/PR_000012867 denotes plasminogen
T155 1086-1095 http://purl.obolibrary.org/obo/CLO_0001658 denotes activator

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T221 44-51 Chemical denotes heparin http://purl.obolibrary.org/obo/CHEBI_28304
T222 128-141 Chemical denotes anticoagulant http://purl.obolibrary.org/obo/CHEBI_50249
T223 496-511 Chemical denotes heparan sulfate http://purl.obolibrary.org/obo/CHEBI_28815
T224 496-503 Chemical denotes heparan http://purl.obolibrary.org/obo/CHEBI_24500
T225 504-511 Chemical denotes sulfate http://purl.obolibrary.org/obo/CHEBI_16189
T226 519-526 Chemical denotes heparin http://purl.obolibrary.org/obo/CHEBI_28304
T227 560-567 Chemical denotes heparin http://purl.obolibrary.org/obo/CHEBI_28304
T228 573-578 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T229 641-648 Chemical denotes heparin http://purl.obolibrary.org/obo/CHEBI_28304
T230 799-810 Chemical denotes angiotensin http://purl.obolibrary.org/obo/CHEBI_48433
T231 832-835 Chemical denotes APC http://purl.obolibrary.org/obo/CHEBI_80551
T232 847-854 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T233 858-860 Chemical denotes HS http://purl.obolibrary.org/obo/CHEBI_74056|http://purl.obolibrary.org/obo/CHEBI_28815
T235 862-877 Chemical denotes heparan sulfate http://purl.obolibrary.org/obo/CHEBI_28815
T236 862-869 Chemical denotes heparan http://purl.obolibrary.org/obo/CHEBI_24500
T237 870-877 Chemical denotes sulfate http://purl.obolibrary.org/obo/CHEBI_16189
T238 879-881 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T240 925-934 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T241 938-940 Chemical denotes TF http://purl.obolibrary.org/obo/CHEBI_74862
T242 977-994 Chemical denotes pathway inhibitor http://purl.obolibrary.org/obo/CHEBI_76932
T243 985-994 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T41 903-924 http://purl.obolibrary.org/obo/GO_0031639 denotes plasminogen activator
T42 1007-1015 http://purl.obolibrary.org/obo/GO_0070265 denotes necrosis
T43 1007-1015 http://purl.obolibrary.org/obo/GO_0019835 denotes necrosis
T44 1007-1015 http://purl.obolibrary.org/obo/GO_0008219 denotes necrosis
T45 1007-1015 http://purl.obolibrary.org/obo/GO_0001906 denotes necrosis
T46 1036-1057 http://purl.obolibrary.org/obo/GO_0031639 denotes plasminogen activator
T47 1074-1095 http://purl.obolibrary.org/obo/GO_0031639 denotes plasminogen activator

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T121 0-91 Sentence denotes Summary of potential therapeutic effects of heparin in coronavirus disease 2019 (COVID-19).
T122 92-317 Sentence denotes 1) Heparin’s classic function as an anticoagulant, through its interaction with antithrombin-III (AT3), may prove beneficial because of the high prevalence of coagulopathy and clinically significant thrombosis in the disease.
T123 318-631 Sentence denotes 2) Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) entry into both endothelial and epithelial cells is believed to be dependent on its interaction with cell surface heparan sulfate; thus, heparin (or carefully designed synthetic heparin-like drugs) may inhibit this interaction and block viral entry.
T124 632-721 Sentence denotes 3) Last, heparin has known anti-inflammatory effects that may confer benefit in COVID-19.
T125 722-792 Sentence denotes This illustration was created with BioRender (https://biorender.com/).
T126 793-1113 Sentence denotes ACE2, angiotensin-converting enzyme 2; APC, activated protein C; HS, heparan sulfate; IL, interleukin; PAI-1, plasminogen activator inhibitor 1; TF, tissue factor; TFPI, tissue factor pathway inhibitor; TNF, tumor necrosis factor; tPA, tissue plasminogen activator; uPA, urokinase plasminogen activator, VII, factor VII.

LitCovid-PD-GlycoEpitope

Id Subject Object Predicate Lexical cue glyco_epitope_db_id
T16 496-511 GlycoEpitope denotes heparan sulfate http://www.glycoepitope.jp/epitopes/EP0086
T17 858-860 GlycoEpitope denotes HS http://www.glycoepitope.jp/epitopes/EP0086
T18 862-877 GlycoEpitope denotes heparan sulfate http://www.glycoepitope.jp/epitopes/EP0086

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T45 251-263 Phenotype denotes coagulopathy http://purl.obolibrary.org/obo/HP_0003256
T46 1001-1006 Phenotype denotes tumor http://purl.obolibrary.org/obo/HP_0002664