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PMC:7381711 / 19171-21053 JSONTXT

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LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T170 81-88 Body_part denotes heparin http://purl.org/sig/ont/fma/fma82839
T171 310-317 Body_part denotes heparin http://purl.org/sig/ont/fma/fma82839
T172 578-585 Body_part denotes heparin http://purl.org/sig/ont/fma/fma82839
T173 719-726 Body_part denotes heparin http://purl.org/sig/ont/fma/fma82839
T174 813-820 Body_part denotes heparin http://purl.org/sig/ont/fma/fma82839
T175 864-873 Body_part denotes Heparin’s http://purl.org/sig/ont/fma/fma82839
T176 1183-1199 Body_part denotes epithelial cells http://purl.org/sig/ont/fma/fma66768
T177 1194-1199 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T178 1252-1264 Body_part denotes cell surface http://purl.org/sig/ont/fma/fma67653
T179 1252-1256 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T180 1265-1280 Body_part denotes heparan sulfate http://purl.org/sig/ont/fma/fma63023
T181 1288-1295 Body_part denotes heparin http://purl.org/sig/ont/fma/fma82839
T182 1329-1336 Body_part denotes heparin http://purl.org/sig/ont/fma/fma82839
T183 1410-1417 Body_part denotes heparin http://purl.org/sig/ont/fma/fma82839
T184 1616-1623 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T185 1627-1629 Body_part denotes HS http://purl.org/sig/ont/fma/fma63023
T186 1631-1646 Body_part denotes heparan sulfate http://purl.org/sig/ont/fma/fma63023
T187 1648-1650 Body_part denotes IL http://purl.org/sig/ont/fma/fma86578
T188 1652-1663 Body_part denotes interleukin http://purl.org/sig/ont/fma/fma86578
T189 1711-1717 Body_part denotes tissue http://purl.org/sig/ont/fma/fma9637
T190 1732-1738 Body_part denotes tissue http://purl.org/sig/ont/fma/fma9637
T191 1798-1804 Body_part denotes tissue http://purl.org/sig/ont/fma/fma9637

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T21 1711-1717 Body_part denotes tissue http://purl.obolibrary.org/obo/UBERON_0000479
T22 1732-1738 Body_part denotes tissue http://purl.obolibrary.org/obo/UBERON_0000479
T23 1798-1804 Body_part denotes tissue http://purl.obolibrary.org/obo/UBERON_0000479

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
668 81-88 Chemical denotes heparin MESH:D006493
669 310-317 Chemical denotes heparin MESH:D006493
670 578-585 Chemical denotes heparin MESH:D006493
671 719-726 Chemical denotes heparin MESH:D006493
672 62-70 Disease denotes COVID-19 MESH:C000657245
673 126-138 Disease denotes coagulopathy MESH:D001778
674 225-235 Disease denotes thrombosis MESH:D013927
675 239-247 Disease denotes COVID-19 MESH:C000657245
676 390-398 Disease denotes COVID-19 MESH:C000657245
677 655-667 Disease denotes coagulopathy MESH:D001778
678 671-687 Disease denotes critical illness MESH:D016638
679 730-738 Disease denotes COVID-19 MESH:C000657245
708 941-957 Gene denotes antithrombin-III Gene:462
709 959-962 Gene denotes AT3 Gene:462
710 1562-1566 Gene denotes ACE2 Gene:59272
711 1568-1599 Gene denotes angiotensin-converting enzyme 2 Gene:59272
712 1601-1604 Gene denotes APC Gene:324
713 1665-1670 Gene denotes PAI-1 Gene:5054
714 1672-1705 Gene denotes plasminogen activator inhibitor 1 Gene:5054
715 1726-1730 Gene denotes TFPI Gene:7035
716 1732-1763 Gene denotes tissue factor pathway inhibitor Gene:7035
717 1765-1768 Gene denotes TNF Gene:7124
718 1828-1831 Gene denotes uPA Gene:5328
719 1711-1724 Gene denotes tissue factor Gene:2152
720 1798-1826 Gene denotes tissue plasminogen activator Gene:100128998
721 1090-1137 Species denotes Severe acute respiratory syndrome coronavirus 2 Tax:2697049
722 1139-1149 Species denotes SARS-CoV-2 Tax:2697049
723 813-820 Chemical denotes heparin MESH:D006493
724 864-871 Chemical denotes Heparin MESH:D006493
725 1265-1280 Chemical denotes heparan sulfate MESH:D006497
726 1288-1295 Chemical denotes heparin MESH:D006493
727 1329-1336 Chemical denotes heparin MESH:D006493
728 1410-1417 Chemical denotes heparin MESH:D006493
729 1631-1646 Chemical denotes heparan sulfate MESH:D006497
730 824-848 Disease denotes coronavirus disease 2019 MESH:C000657245
731 850-858 Disease denotes COVID-19 MESH:C000657245
732 1020-1032 Disease denotes coagulopathy MESH:D001778
733 1060-1070 Disease denotes thrombosis MESH:D013927
734 1481-1489 Disease denotes COVID-19 MESH:C000657245
735 1770-1784 Disease denotes tumor necrosis MESH:D009336

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T159 62-70 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T160 126-138 Disease denotes coagulopathy http://purl.obolibrary.org/obo/MONDO_0001531
T161 225-235 Disease denotes thrombosis http://purl.obolibrary.org/obo/MONDO_0000831
T162 239-247 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T163 390-398 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T164 655-667 Disease denotes coagulopathy http://purl.obolibrary.org/obo/MONDO_0001531
T165 730-738 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T166 824-848 Disease denotes coronavirus disease 2019 http://purl.obolibrary.org/obo/MONDO_0100096
T167 850-858 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T168 1020-1032 Disease denotes coagulopathy http://purl.obolibrary.org/obo/MONDO_0001531
T169 1060-1070 Disease denotes thrombosis http://purl.obolibrary.org/obo/MONDO_0000831
T170 1090-1137 Disease denotes Severe acute respiratory syndrome coronavirus 2 http://purl.obolibrary.org/obo/MONDO_0100096
T171 1139-1147 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T172 1139-1143 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T173 1481-1489 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T174 1770-1775 Disease denotes tumor http://purl.obolibrary.org/obo/MONDO_0005070
T175 1828-1831 Disease denotes uPA http://purl.obolibrary.org/obo/MONDO_0004041

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T140 21-22 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T141 248-251 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T142 1183-1193 http://purl.obolibrary.org/obo/CL_0000066 denotes epithelial
T143 1194-1199 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T144 1252-1256 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T145 1418-1421 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T146 1606-1615 http://purl.obolibrary.org/obo/CLO_0001658 denotes activated
T147 1672-1683 http://purl.obolibrary.org/obo/PR_000012867 denotes plasminogen
T148 1684-1693 http://purl.obolibrary.org/obo/CLO_0001658 denotes activator
T149 1793-1796 http://purl.obolibrary.org/obo/CLO_0053275 denotes tPA
T150 1793-1796 http://purl.obolibrary.org/obo/CLO_0053276 denotes tPA
T151 1793-1796 http://purl.obolibrary.org/obo/CLO_0053277 denotes tPA
T152 1805-1816 http://purl.obolibrary.org/obo/PR_000012867 denotes plasminogen
T153 1817-1826 http://purl.obolibrary.org/obo/CLO_0001658 denotes activator
T154 1843-1854 http://purl.obolibrary.org/obo/PR_000012867 denotes plasminogen
T155 1855-1864 http://purl.obolibrary.org/obo/CLO_0001658 denotes activator

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T215 81-88 Chemical denotes heparin http://purl.obolibrary.org/obo/CHEBI_28304
T216 310-317 Chemical denotes heparin http://purl.obolibrary.org/obo/CHEBI_28304
T217 342-355 Chemical denotes anticoagulant http://purl.obolibrary.org/obo/CHEBI_50249
T218 413-422 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T219 578-585 Chemical denotes heparin http://purl.obolibrary.org/obo/CHEBI_28304
T220 719-726 Chemical denotes heparin http://purl.obolibrary.org/obo/CHEBI_28304
T221 813-820 Chemical denotes heparin http://purl.obolibrary.org/obo/CHEBI_28304
T222 897-910 Chemical denotes anticoagulant http://purl.obolibrary.org/obo/CHEBI_50249
T223 1265-1280 Chemical denotes heparan sulfate http://purl.obolibrary.org/obo/CHEBI_28815
T224 1265-1272 Chemical denotes heparan http://purl.obolibrary.org/obo/CHEBI_24500
T225 1273-1280 Chemical denotes sulfate http://purl.obolibrary.org/obo/CHEBI_16189
T226 1288-1295 Chemical denotes heparin http://purl.obolibrary.org/obo/CHEBI_28304
T227 1329-1336 Chemical denotes heparin http://purl.obolibrary.org/obo/CHEBI_28304
T228 1342-1347 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T229 1410-1417 Chemical denotes heparin http://purl.obolibrary.org/obo/CHEBI_28304
T230 1568-1579 Chemical denotes angiotensin http://purl.obolibrary.org/obo/CHEBI_48433
T231 1601-1604 Chemical denotes APC http://purl.obolibrary.org/obo/CHEBI_80551
T232 1616-1623 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T233 1627-1629 Chemical denotes HS http://purl.obolibrary.org/obo/CHEBI_74056|http://purl.obolibrary.org/obo/CHEBI_28815
T235 1631-1646 Chemical denotes heparan sulfate http://purl.obolibrary.org/obo/CHEBI_28815
T236 1631-1638 Chemical denotes heparan http://purl.obolibrary.org/obo/CHEBI_24500
T237 1639-1646 Chemical denotes sulfate http://purl.obolibrary.org/obo/CHEBI_16189
T238 1648-1650 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T240 1694-1703 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T241 1707-1709 Chemical denotes TF http://purl.obolibrary.org/obo/CHEBI_74862
T242 1746-1763 Chemical denotes pathway inhibitor http://purl.obolibrary.org/obo/CHEBI_76932
T243 1754-1763 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T41 1672-1693 http://purl.obolibrary.org/obo/GO_0031639 denotes plasminogen activator
T42 1776-1784 http://purl.obolibrary.org/obo/GO_0070265 denotes necrosis
T43 1776-1784 http://purl.obolibrary.org/obo/GO_0019835 denotes necrosis
T44 1776-1784 http://purl.obolibrary.org/obo/GO_0008219 denotes necrosis
T45 1776-1784 http://purl.obolibrary.org/obo/GO_0001906 denotes necrosis
T46 1805-1826 http://purl.obolibrary.org/obo/GO_0031639 denotes plasminogen activator
T47 1843-1864 http://purl.obolibrary.org/obo/GO_0031639 denotes plasminogen activator

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T115 0-11 Sentence denotes CONCLUSIONS
T116 12-71 Sentence denotes There is a paucity of pharmacologic therapies for COVID-19.
T117 72-286 Sentence denotes Although heparin may prove beneficial in treating the coagulopathy of this disease, utilization of therapeutic anticoagulation before the development of thrombosis in COVID-19 has not been systematically evaluated.
T118 287-511 Sentence denotes Additionally, although heparin is known to possess non-anticoagulant effects that may be beneficial in COVID-19 (i.e., direct antiviral and anti-inflammatory), the balance between its benefits and risks should be considered.
T119 512-759 Sentence denotes Given the potential benefits (and uncertain risks) of therapeutic heparin (see Fig. 3), tempered by the failures of previous studies targeting coagulopathy in critical illness, randomized clinical trials of heparin in COVID-19 are urgently needed.
T120 760-767 Sentence denotes Fig. 3.
T121 769-860 Sentence denotes Summary of potential therapeutic effects of heparin in coronavirus disease 2019 (COVID-19).
T122 861-1086 Sentence denotes 1) Heparin’s classic function as an anticoagulant, through its interaction with antithrombin-III (AT3), may prove beneficial because of the high prevalence of coagulopathy and clinically significant thrombosis in the disease.
T123 1087-1400 Sentence denotes 2) Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) entry into both endothelial and epithelial cells is believed to be dependent on its interaction with cell surface heparan sulfate; thus, heparin (or carefully designed synthetic heparin-like drugs) may inhibit this interaction and block viral entry.
T124 1401-1490 Sentence denotes 3) Last, heparin has known anti-inflammatory effects that may confer benefit in COVID-19.
T125 1491-1561 Sentence denotes This illustration was created with BioRender (https://biorender.com/).
T126 1562-1882 Sentence denotes ACE2, angiotensin-converting enzyme 2; APC, activated protein C; HS, heparan sulfate; IL, interleukin; PAI-1, plasminogen activator inhibitor 1; TF, tissue factor; TFPI, tissue factor pathway inhibitor; TNF, tumor necrosis factor; tPA, tissue plasminogen activator; uPA, urokinase plasminogen activator, VII, factor VII.

LitCovid-PD-GlycoEpitope

Id Subject Object Predicate Lexical cue glyco_epitope_db_id
T16 1265-1280 GlycoEpitope denotes heparan sulfate http://www.glycoepitope.jp/epitopes/EP0086
T17 1627-1629 GlycoEpitope denotes HS http://www.glycoepitope.jp/epitopes/EP0086
T18 1631-1646 GlycoEpitope denotes heparan sulfate http://www.glycoepitope.jp/epitopes/EP0086

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T43 126-138 Phenotype denotes coagulopathy http://purl.obolibrary.org/obo/HP_0003256
T44 655-667 Phenotype denotes coagulopathy http://purl.obolibrary.org/obo/HP_0003256
T45 1020-1032 Phenotype denotes coagulopathy http://purl.obolibrary.org/obo/HP_0003256
T46 1770-1775 Phenotype denotes tumor http://purl.obolibrary.org/obo/HP_0002664