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PMC:7381711 / 16609-19169 JSONTXT

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LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T144 44-51 Body_part denotes HEPARIN http://purl.org/sig/ont/fma/fma82839
T145 71-78 Body_part denotes heparin http://purl.org/sig/ont/fma/fma82839
T146 349-365 Body_part denotes white blood cell http://purl.org/sig/ont/fma/fma62852
T147 361-365 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T148 370-378 Body_part denotes platelet http://purl.org/sig/ont/fma/fma62851
T149 520-527 Body_part denotes heparin http://purl.org/sig/ont/fma/fma82839
T150 606-613 Body_part denotes heparin http://purl.org/sig/ont/fma/fma82839
T151 705-712 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T152 713-721 Body_part denotes platelet http://purl.org/sig/ont/fma/fma62851
T153 872-879 Body_part denotes heparin http://purl.org/sig/ont/fma/fma82839
T154 918-922 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T155 1116-1120 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T156 1214-1218 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T157 1333-1350 Body_part denotes epithelial tissue http://purl.org/sig/ont/fma/fma9639
T158 1455-1461 Body_part denotes tissue http://purl.org/sig/ont/fma/fma9637
T159 1561-1569 Body_part denotes alveolar http://purl.org/sig/ont/fma/fma264783
T160 1731-1739 Body_part denotes alveolar http://purl.org/sig/ont/fma/fma264783
T161 1846-1853 Body_part denotes heparin http://purl.org/sig/ont/fma/fma82839
T162 1915-1922 Body_part denotes heparin http://purl.org/sig/ont/fma/fma82839
T163 2059-2066 Body_part denotes heparin http://purl.org/sig/ont/fma/fma82839
T164 2140-2158 Body_part denotes intestinal mucosae http://purl.org/sig/ont/fma/fma15695
T165 2160-2175 Body_part denotes heparan sulfate http://purl.org/sig/ont/fma/fma63023
T166 2176-2191 Body_part denotes polysaccharides http://purl.org/sig/ont/fma/fma82746
T167 2430-2437 Body_part denotes heparin http://purl.org/sig/ont/fma/fma82839
T168 2499-2504 Body_part denotes organ http://purl.org/sig/ont/fma/fma67498
T169 2529-2534 Body_part denotes organ http://purl.org/sig/ont/fma/fma67498

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T12 355-360 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T13 918-922 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T14 1116-1120 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T15 1214-1218 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T16 1344-1350 Body_part denotes tissue http://purl.obolibrary.org/obo/UBERON_0000479
T17 1455-1461 Body_part denotes tissue http://purl.obolibrary.org/obo/UBERON_0000479
T18 2140-2158 Body_part denotes intestinal mucosae http://purl.obolibrary.org/obo/UBERON_0001242
T19 2499-2504 Body_part denotes organ http://purl.obolibrary.org/obo/UBERON_0000062
T20 2529-2534 Body_part denotes organ http://purl.obolibrary.org/obo/UBERON_0000062

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
583 44-51 Chemical denotes HEPARIN MESH:D006493
598 457-465 Species denotes patients Tax:9606
599 585-593 Species denotes patients Tax:9606
600 71-78 Chemical denotes heparin MESH:D006493
601 520-527 Chemical denotes heparin MESH:D006493
602 606-613 Chemical denotes heparin MESH:D006493
603 158-166 Disease denotes bleeding MESH:D006470
604 203-211 Disease denotes bleeding MESH:D006470
605 263-269 Disease denotes trauma MESH:D014947
606 339-365 Disease denotes decreased white blood cell MESH:D007022
607 427-435 Disease denotes bleeding MESH:D006470
608 471-479 Disease denotes COVID-19 MESH:C000657245
609 539-542 Disease denotes HIT MESH:D013921
610 764-780 Disease denotes thrombocytopenia MESH:D013921
611 812-822 Disease denotes thrombosis MESH:D013927
628 1455-1468 Gene denotes tissue factor Gene:2152
629 1344-1357 Gene denotes tissue factor Gene:2152
630 1399-1408 Species denotes influenza Tax:11320
631 1499-1508 Species denotes influenza Tax:11320
632 872-879 Chemical denotes heparin MESH:D006493
633 1846-1853 Chemical denotes heparin MESH:D006493
634 993-1001 Disease denotes COVID-19 MESH:C000657245
635 1012-1028 Disease denotes critical illness MESH:D016638
636 1040-1064 Disease denotes intravascular thrombosis MESH:D013927
637 1116-1127 Disease denotes lung injury MESH:D055370
638 1288-1303 Disease denotes viral pneumonia
639 1383-1392 Disease denotes mortality MESH:D003643
640 1409-1418 Disease denotes infection MESH:D007239
641 1688-1697 Disease denotes infection MESH:D007239
642 1744-1769 Disease denotes intravascular coagulation MESH:D004211
643 1895-1904 Disease denotes pneumonia MESH:D011014
650 2275-2278 Gene denotes AT3 Gene:462
651 1915-1922 Chemical denotes heparin MESH:D006493
652 2059-2066 Chemical denotes heparin MESH:D006493
653 2160-2191 Chemical denotes heparan sulfate polysaccharides
654 2236-2251 Chemical denotes pentasaccharide
655 2430-2437 Chemical denotes heparin MESH:D006493

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T143 263-269 Disease denotes trauma http://purl.obolibrary.org/obo/MONDO_0021178
T144 471-479 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T145 539-542 Disease denotes HIT http://purl.obolibrary.org/obo/MONDO_0018048
T146 764-780 Disease denotes thrombocytopenia http://purl.obolibrary.org/obo/MONDO_0002049
T147 812-822 Disease denotes thrombosis http://purl.obolibrary.org/obo/MONDO_0000831
T148 993-1001 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T149 1054-1064 Disease denotes thrombosis http://purl.obolibrary.org/obo/MONDO_0000831
T150 1121-1127 Disease denotes injury http://purl.obolibrary.org/obo/MONDO_0021178
T151 1288-1303 Disease denotes viral pneumonia http://purl.obolibrary.org/obo/MONDO_0006012
T152 1294-1303 Disease denotes pneumonia http://purl.obolibrary.org/obo/MONDO_0005249
T153 1399-1418 Disease denotes influenza infection http://purl.obolibrary.org/obo/MONDO_0005812
T154 1409-1418 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T155 1499-1508 Disease denotes influenza http://purl.obolibrary.org/obo/MONDO_0005812
T156 1517-1523 Disease denotes injury http://purl.obolibrary.org/obo/MONDO_0021178
T157 1688-1697 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T158 1895-1904 Disease denotes pneumonia http://purl.obolibrary.org/obo/MONDO_0005249

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T107 82-83 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T108 129-133 http://purl.obolibrary.org/obo/CLO_0001550 denotes a 10
T109 168-170 http://purl.obolibrary.org/obo/CLO_0053733 denotes 11
T110 172-174 http://purl.obolibrary.org/obo/CLO_0050509 denotes 27
T111 355-360 http://www.ebi.ac.uk/efo/EFO_0000296 denotes blood
T112 361-365 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T113 387-389 http://purl.obolibrary.org/obo/CLO_0053733 denotes 11
T114 391-393 http://purl.obolibrary.org/obo/CLO_0050509 denotes 27
T115 481-482 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T116 918-922 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T117 918-922 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T118 1065-1068 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T119 1099-1105 http://purl.obolibrary.org/obo/NCBITaxon_33208 denotes animal
T120 1116-1120 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T121 1116-1120 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T122 1175-1182 http://purl.obolibrary.org/obo/UBERON_0001005 denotes airways
T123 1183-1186 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T124 1214-1218 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T125 1214-1218 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T126 1234-1236 http://purl.obolibrary.org/obo/CLO_0001302 denotes 34
T127 1271-1277 http://purl.obolibrary.org/obo/NCBITaxon_33208 denotes animal
T128 1333-1350 http://purl.obolibrary.org/obo/UBERON_0000483 denotes epithelial tissue
T129 1376-1382 http://purl.obolibrary.org/obo/NCBITaxon_33208 denotes animal
T130 1592-1593 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T131 2082-2083 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T132 2140-2150 http://purl.obolibrary.org/obo/UBERON_0000160 denotes intestinal
T133 2140-2150 http://www.ebi.ac.uk/efo/EFO_0000834 denotes intestinal
T134 2151-2158 http://purl.obolibrary.org/obo/UBERON_0000344 denotes mucosae
T135 2234-2235 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T136 2279-2289 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T137 2335-2336 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T138 2499-2504 http://purl.obolibrary.org/obo/UBERON_0003103 denotes organ
T139 2529-2534 http://purl.obolibrary.org/obo/UBERON_0003103 denotes organ

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T197 71-78 Chemical denotes heparin http://purl.obolibrary.org/obo/CHEBI_28304
T198 96-109 Chemical denotes anticoagulant http://purl.obolibrary.org/obo/CHEBI_50249
T199 520-527 Chemical denotes heparin http://purl.obolibrary.org/obo/CHEBI_28304
T200 606-613 Chemical denotes heparin http://purl.obolibrary.org/obo/CHEBI_28304
T201 705-712 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T202 872-879 Chemical denotes heparin http://purl.obolibrary.org/obo/CHEBI_28304
T203 1812-1826 Chemical denotes anticoagulants http://purl.obolibrary.org/obo/CHEBI_50249
T204 1846-1853 Chemical denotes heparin http://purl.obolibrary.org/obo/CHEBI_28304
T205 1915-1922 Chemical denotes heparin http://purl.obolibrary.org/obo/CHEBI_28304
T206 2059-2066 Chemical denotes heparin http://purl.obolibrary.org/obo/CHEBI_28304
T207 2084-2091 Chemical denotes mixture http://purl.obolibrary.org/obo/CHEBI_60004
T208 2160-2175 Chemical denotes heparan sulfate http://purl.obolibrary.org/obo/CHEBI_28815
T209 2160-2167 Chemical denotes heparan http://purl.obolibrary.org/obo/CHEBI_24500
T210 2168-2175 Chemical denotes sulfate http://purl.obolibrary.org/obo/CHEBI_16189
T211 2176-2191 Chemical denotes polysaccharides http://purl.obolibrary.org/obo/CHEBI_18154
T212 2236-2251 Chemical denotes pentasaccharide http://purl.obolibrary.org/obo/CHEBI_35369
T213 2390-2403 Chemical denotes anticoagulant http://purl.obolibrary.org/obo/CHEBI_50249
T214 2430-2437 Chemical denotes heparin http://purl.obolibrary.org/obo/CHEBI_28304

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T34 947-958 http://purl.obolibrary.org/obo/GO_0050817 denotes coagulation
T35 1134-1145 http://purl.obolibrary.org/obo/GO_0050817 denotes coagulation
T36 1570-1581 http://purl.obolibrary.org/obo/GO_0050817 denotes coagulation
T37 1758-1769 http://purl.obolibrary.org/obo/GO_0050817 denotes coagulation
T38 2359-2368 http://purl.obolibrary.org/obo/GO_0051923 denotes sulfation
T39 2404-2413 http://purl.obolibrary.org/obo/GO_0051923 denotes sulfation
T40 2457-2463 http://purl.obolibrary.org/obo/GO_0040007 denotes growth

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T100 0-59 Sentence denotes POTENTIAL ADVERSE AND OFF-TARGET EFFECTS OF HEPARIN THERAPY
T101 60-176 Sentence denotes The use of heparin as a therapeutic anticoagulant is associated with a 10–15% risk of significant bleeding (11, 27).
T102 177-395 Sentence denotes Factors that may increase bleeding risk are older age, worse illness severity, recent trauma or surgery, cardiopulmonary resuscitation, longer hospital stay, and decreased white blood cell and platelet counts (11, 27).
T103 396-480 Sentence denotes Many of these risk factors for bleeding are commonly seen in patients with COVID-19.
T104 481-618 Sentence denotes A second, albeit rare, complication of heparin therapy is HIT, which is estimated to occur in 0.2–3% of patients who receive heparin (4).
T105 619-823 Sentence denotes This feared adverse effect is driven by the development of antibodies specific to the protein platelet factor 4, which leads to life-threatening thrombocytopenia and paradoxical development of thrombosis.
T106 824-1002 Sentence denotes It is also possible that the intended effect of heparin (i.e., anticoagulation) can interrupt lung-protective processes of coagulation that may improve host survival in COVID-19.
T107 1003-1238 Sentence denotes Although critical illness-associated intravascular thrombosis has been recognized as harmful in animal models of lung injury (44), coagulation occurring within alveoli and airways has generally been found to be lung protective (9, 34).
T108 1239-1423 Sentence denotes This is particularly notable in animal models of viral pneumonia, in which transgenic loss of epithelial tissue factor markedly worsened animal mortality after influenza infection (3).
T109 1424-1524 Sentence denotes Transgenic loss of endothelial tissue factor, conversely, had no effect on influenza-induced injury.
T110 1525-1698 Sentence denotes It is therefore possible that intra-alveolar coagulation may serve a teleological function of isolating pulmonary pathogens, protecting the host from disseminated infection.
T111 1699-1905 Sentence denotes Such divergent effects of intra-alveolar and intravascular coagulation may in part explain the muted benefits of anticoagulants [including inhaled heparin (6)] in randomized controlled studies of pneumonia.
T112 1906-2033 Sentence denotes Finally, heparin may have many other unrecognized effects—both protective and harmful—arising from its heterogeneous structure.
T113 2034-2379 Sentence denotes As noted, unfractionated heparin is composed of a mixture of distinct biologically derived (i.e., porcine intestinal mucosae) heparan sulfate polysaccharides, which on balance not only is enriched in a pentasaccharide sequence necessary for AT3 activation (and thus anticoagulation) but also displays a wide variety of other sulfation sequences.
T114 2380-2560 Sentence denotes These non-anticoagulant sulfation sequences allow heparin binding to various growth factors, potentially exerting both organ-protective (46, 49) and organ-harmful (14, 20) effects.

LitCovid-PD-GlycoEpitope

Id Subject Object Predicate Lexical cue glyco_epitope_db_id
T15 2160-2175 GlycoEpitope denotes heparan sulfate http://www.glycoepitope.jp/epitopes/EP0086

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T39 539-542 Phenotype denotes HIT http://purl.obolibrary.org/obo/HP_0011874
T40 764-780 Phenotype denotes thrombocytopenia http://purl.obolibrary.org/obo/HP_0001873
T41 1294-1303 Phenotype denotes pneumonia http://purl.obolibrary.org/obo/HP_0002090
T42 1895-1904 Phenotype denotes pneumonia http://purl.obolibrary.org/obo/HP_0002090

2_test

Id Subject Object Predicate Lexical cue
32519894-20442353-2138200 168-170 20442353 denotes 11
32519894-1657248-2138201 172-174 1657248 denotes 27
32519894-20442353-2138202 387-389 20442353 denotes 11
32519894-1657248-2138203 391-393 1657248 denotes 27
32519894-28416511-2138204 615-616 28416511 denotes 4
32519894-11734456-2138205 1129-1131 11734456 denotes 44
32519894-23033361-2138206 1231-1232 23033361 denotes 9
32519894-25884207-2138207 1234-1236 25884207 denotes 34
32519894-26947929-2138208 1420-1421 26947929 denotes 3
32519894-27288618-2138209 1855-1856 27288618 denotes 6
32519894-28187268-2138210 2517-2519 28187268 denotes 46
32519894-28538085-2138211 2521-2523 28538085 denotes 49
32519894-30720464-2138212 2544-2546 30720464 denotes 14
32519894-32320623-2138213 2548-2550 32320623 denotes 20