PMC:7381711 / 14864-16223
Annnotations
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T122 | 58-65 | Body_part | denotes | heparin | http://purl.org/sig/ont/fma/fma82839 |
| T123 | 421-430 | Body_part | denotes | cytokines | http://purl.org/sig/ont/fma/fma84050 |
| T124 | 457-465 | Body_part | denotes | proteins | http://purl.org/sig/ont/fma/fma67257 |
| T125 | 509-513 | Body_part | denotes | IL-1 | http://purl.org/sig/ont/fma/fma86583 |
| T126 | 509-511 | Body_part | denotes | IL | http://purl.org/sig/ont/fma/fma86578 |
| T127 | 516-518 | Body_part | denotes | IL | http://purl.org/sig/ont/fma/fma86578 |
| T128 | 526-528 | Body_part | denotes | IL | http://purl.org/sig/ont/fma/fma86578 |
| T129 | 541-548 | Body_part | denotes | Heparin | http://purl.org/sig/ont/fma/fma82839 |
| T130 | 626-643 | Body_part | denotes | endothelial cells | http://purl.org/sig/ont/fma/fma66772 |
| T131 | 638-643 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T132 | 654-663 | Body_part | denotes | monocytes | http://purl.org/sig/ont/fma/fma62864 |
| T133 | 693-700 | Body_part | denotes | heparin | http://purl.org/sig/ont/fma/fma82839 |
| T134 | 925-929 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
| T135 | 1016-1023 | Body_part | denotes | heparin | http://purl.org/sig/ont/fma/fma82839 |
| T136 | 1060-1077 | Body_part | denotes | endothelial cells | http://purl.org/sig/ont/fma/fma66772 |
| T137 | 1072-1077 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T138 | 1123-1136 | Body_part | denotes | immune system | http://purl.org/sig/ont/fma/fma9825 |
| T139 | 1162-1172 | Body_part | denotes | neutrophil | http://purl.org/sig/ont/fma/fma62860 |
| T140 | 1204-1211 | Body_part | denotes | heparin | http://purl.org/sig/ont/fma/fma82839 |
LitCovid-PD-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T11 | 1123-1136 | Body_part | denotes | immune system | http://purl.obolibrary.org/obo/UBERON_0002405 |
LitCovid-PubTator
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
|---|---|---|---|---|---|
| 547 | 476-499 | Gene | denotes | tumor necrosis factor-α | Gene:7124 |
| 548 | 501-506 | Gene | denotes | TNF-α | Gene:7124 |
| 549 | 509-514 | Gene | denotes | IL-1β | Gene:3552 |
| 550 | 516-520 | Gene | denotes | IL-6 | Gene:3569 |
| 551 | 526-530 | Gene | denotes | IL-8 | Gene:3576 |
| 552 | 756-781 | Gene | denotes | high mobility group box 1 | Gene:3146 |
| 553 | 783-788 | Gene | denotes | HMGB1 | Gene:3146 |
| 554 | 274-282 | Species | denotes | SARS-CoV | Tax:694009 |
| 555 | 620-625 | Species | denotes | human | Tax:9606 |
| 556 | 648-653 | Species | denotes | human | Tax:9606 |
| 557 | 58-65 | Chemical | denotes | heparin | MESH:D006493 |
| 558 | 541-548 | Chemical | denotes | Heparin | MESH:D006493 |
| 559 | 605-608 | Chemical | denotes | LPS | MESH:D008070 |
| 560 | 693-700 | Chemical | denotes | heparin | MESH:D006493 |
| 561 | 1016-1023 | Chemical | denotes | heparin | MESH:D006493 |
| 562 | 1204-1211 | Chemical | denotes | heparin | MESH:D006493 |
| 563 | 77-89 | Disease | denotes | inflammation | MESH:D007249 |
| 564 | 873-889 | Disease | denotes | viral infections | MESH:D001102 |
| 565 | 998-1006 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 566 | 1237-1249 | Disease | denotes | inflammation | MESH:D007249 |
| 567 | 1302-1314 | Disease | denotes | inflammation | MESH:D007249 |
| 568 | 1325-1337 | Disease | denotes | pancreatitis | MESH:D010195 |
| 569 | 1347-1353 | Disease | denotes | sepsis | MESH:D018805 |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T129 | 77-89 | Disease | denotes | inflammation | http://purl.obolibrary.org/obo/MONDO_0021166 |
| T130 | 274-282 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T131 | 274-278 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T132 | 314-347 | Disease | denotes | severe acute respiratory syndrome | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T133 | 349-353 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T134 | 476-481 | Disease | denotes | tumor | http://purl.obolibrary.org/obo/MONDO_0005070 |
| T135 | 873-889 | Disease | denotes | viral infections | http://purl.obolibrary.org/obo/MONDO_0005108 |
| T136 | 998-1006 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T137 | 1237-1249 | Disease | denotes | inflammation | http://purl.obolibrary.org/obo/MONDO_0021166 |
| T138 | 1302-1314 | Disease | denotes | inflammation | http://purl.obolibrary.org/obo/MONDO_0021166 |
| T139 | 1325-1337 | Disease | denotes | pancreatitis | http://purl.obolibrary.org/obo/MONDO_0004982 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T79 | 204-205 | http://purl.obolibrary.org/obo/CLO_0001021 | denotes | B |
| T80 | 211-212 | http://purl.obolibrary.org/obo/CLO_0001021 | denotes | B |
| T81 | 221-224 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
| T82 | 288-293 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T83 | 526-530 | http://purl.obolibrary.org/obo/CLO_0053704 | denotes | IL-8 |
| T84 | 549-552 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
| T85 | 590-591 | http://purl.obolibrary.org/obo/CLO_0001021 | denotes | B |
| T86 | 592-601 | http://purl.obolibrary.org/obo/SO_0000418 | denotes | signaling |
| T87 | 620-625 | http://purl.obolibrary.org/obo/NCBITaxon_9606 | denotes | human |
| T88 | 626-643 | http://purl.obolibrary.org/obo/CL_0000115 | denotes | endothelial cells |
| T89 | 648-653 | http://purl.obolibrary.org/obo/NCBITaxon_9606 | denotes | human |
| T90 | 654-663 | http://purl.obolibrary.org/obo/CL_0000576 | denotes | monocytes |
| T91 | 681-682 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T92 | 711-714 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
| T93 | 794-795 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T94 | 843-844 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T95 | 925-929 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
| T96 | 944-945 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T97 | 962-965 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
| T98 | 1060-1077 | http://purl.obolibrary.org/obo/CL_0000115 | denotes | endothelial cells |
| T99 | 1123-1136 | http://purl.obolibrary.org/obo/UBERON_0002405 | denotes | immune system |
| T100 | 1173-1183 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activation |
| T101 | 1212-1215 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T171 | 58-65 | Chemical | denotes | heparin | http://purl.obolibrary.org/obo/CHEBI_28304 |
| T172 | 207-209 | Chemical | denotes | NF | http://purl.obolibrary.org/obo/CHEBI_141424|http://purl.obolibrary.org/obo/CHEBI_25573|http://purl.obolibrary.org/obo/CHEBI_1224 |
| T175 | 457-465 | Chemical | denotes | proteins | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T176 | 509-511 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
| T178 | 516-518 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
| T180 | 526-528 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
| T182 | 541-548 | Chemical | denotes | Heparin | http://purl.obolibrary.org/obo/CHEBI_28304 |
| T183 | 586-588 | Chemical | denotes | NF | http://purl.obolibrary.org/obo/CHEBI_141424|http://purl.obolibrary.org/obo/CHEBI_25573|http://purl.obolibrary.org/obo/CHEBI_1224 |
| T186 | 605-608 | Chemical | denotes | LPS | http://purl.obolibrary.org/obo/CHEBI_16412|http://purl.obolibrary.org/obo/CHEBI_52603|http://purl.obolibrary.org/obo/CHEBI_89981 |
| T189 | 693-700 | Chemical | denotes | heparin | http://purl.obolibrary.org/obo/CHEBI_28304 |
| T190 | 706-710 | Chemical | denotes | drug | http://purl.obolibrary.org/obo/CHEBI_23888 |
| T191 | 770-775 | Chemical | denotes | group | http://purl.obolibrary.org/obo/CHEBI_24433 |
| T192 | 1016-1023 | Chemical | denotes | heparin | http://purl.obolibrary.org/obo/CHEBI_28304 |
| T193 | 1204-1211 | Chemical | denotes | heparin | http://purl.obolibrary.org/obo/CHEBI_28304 |
LitCovid-PD-GO-BP
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T17 | 77-89 | http://purl.obolibrary.org/obo/GO_0006954 | denotes | inflammation |
| T18 | 167-187 | http://purl.obolibrary.org/obo/GO_0000981 | denotes | transcription factor |
| T19 | 167-180 | http://purl.obolibrary.org/obo/GO_0006351 | denotes | transcription |
| T20 | 258-270 | http://purl.obolibrary.org/obo/GO_0009405 | denotes | pathogenesis |
| T21 | 441-456 | http://purl.obolibrary.org/obo/GO_0006955 | denotes | immune response |
| T22 | 482-490 | http://purl.obolibrary.org/obo/GO_0070265 | denotes | necrosis |
| T23 | 482-490 | http://purl.obolibrary.org/obo/GO_0019835 | denotes | necrosis |
| T24 | 482-490 | http://purl.obolibrary.org/obo/GO_0008219 | denotes | necrosis |
| T25 | 482-490 | http://purl.obolibrary.org/obo/GO_0001906 | denotes | necrosis |
| T26 | 592-601 | http://purl.obolibrary.org/obo/GO_0023052 | denotes | signaling |
| T27 | 857-869 | http://purl.obolibrary.org/obo/GO_0009405 | denotes | pathogenesis |
| T28 | 873-889 | http://purl.obolibrary.org/obo/GO_0016032 | denotes | viral infections |
| T29 | 1116-1129 | http://purl.obolibrary.org/obo/GO_0045087 | denotes | innate immune |
| T30 | 1148-1183 | http://purl.obolibrary.org/obo/GO_1902564 | denotes | inhibition of neutrophil activation |
| T31 | 1162-1183 | http://purl.obolibrary.org/obo/GO_0042119 | denotes | neutrophil activation |
| T32 | 1237-1249 | http://purl.obolibrary.org/obo/GO_0006954 | denotes | inflammation |
| T33 | 1302-1314 | http://purl.obolibrary.org/obo/GO_0006954 | denotes | inflammation |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T92 | 0-146 | Sentence | denotes | There are innumerable studies that have demonstrated that heparin can dampen inflammation through its interaction with key inflammatory mediators. |
| T93 | 147-540 | Sentence | denotes | The proinflammatory transcription factor nuclear factor-κB (NF-κB), which has been found to be involved in the pathogenesis of SARS-CoV, the virus underlying the 2003 severe acute respiratory syndrome (SARS) epidemic (16), leads to the production of downstream inflammatory cytokines and other immune response proteins including tumor necrosis factor-α (TNF-α), IL-1β, IL-6, and IL-8 (13, 47). |
| T94 | 541-669 | Sentence | denotes | Heparin has been observed to directly dampen NF-κB signaling in LPS-stimulated human endothelial cells and human monocytes (21). |
| T95 | 670-895 | Sentence | denotes | Similarly, a synthetic heparin-like drug has recently been developed that neutralizes high mobility group box 1 (HMGB1; 5), a proinflammatory mediator that is known to play a role in the pathogenesis of viral infections (15). |
| T96 | 896-1189 | Sentence | denotes | With respect to inflammatory cell infiltration, a phenomenon that has been observed pathologically in COVID-19 (2, 39), heparin can directly interact with vascular endothelial cells leading to reduced recruitment of the innate immune system and direct inhibition of neutrophil activation (13). |
| T97 | 1190-1359 | Sentence | denotes | More broadly, heparin has been shown to dampen inflammation in other preclinical models characterized by robust inflammation including pancreatitis (12) and sepsis (33). |
LitCovid-PD-HP
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T33 | 476-481 | Phenotype | denotes | tumor | http://purl.obolibrary.org/obo/HP_0002664 |
| T34 | 1325-1337 | Phenotype | denotes | pancreatitis | http://purl.obolibrary.org/obo/HP_0001733 |
| T35 | 1347-1353 | Phenotype | denotes | sepsis | http://purl.obolibrary.org/obo/HP_0100806 |
2_test
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| 32519894-17141229-2138187 | 365-367 | 17141229 | denotes | 16 |
| 32519894-31030744-2138188 | 532-534 | 31030744 | denotes | 13 |
| 32519894-17727922-2138189 | 536-538 | 17727922 | denotes | 47 |
| 32519894-32063752-2138190 | 665-667 | 32063752 | denotes | 21 |
| 32519894-32188725-2138191 | 790-791 | 32188725 | denotes | 5 |
| 32519894-24717031-2138192 | 891-893 | 24717031 | denotes | 15 |
| 32519894-32437596-2138193 | 1008-1009 | 32437596 | denotes | 2 |
| 32519894-32325026-2138194 | 1011-1013 | 32325026 | denotes | 39 |
| 32519894-31030744-2138195 | 1185-1187 | 31030744 | denotes | 13 |
| 32519894-14739847-2138196 | 1339-1341 | 14739847 | denotes | 12 |
| 32519894-22820644-2138197 | 1355-1357 | 22820644 | denotes | 33 |