PMC:7381711 / 12404-13351
Annnotations
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T89 | 97-104 | Body_part | denotes | heparin | http://purl.org/sig/ont/fma/fma82839 |
| T90 | 137-144 | Body_part | denotes | heparin | http://purl.org/sig/ont/fma/fma82839 |
| T91 | 175-182 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T92 | 299-307 | Body_part | denotes | heparins | http://purl.org/sig/ont/fma/fma82839 |
| T93 | 371-378 | Body_part | denotes | heparin | http://purl.org/sig/ont/fma/fma82839 |
| T94 | 415-422 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T95 | 558-565 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T96 | 632-639 | Body_part | denotes | heparin | http://purl.org/sig/ont/fma/fma82839 |
| T97 | 814-821 | Body_part | denotes | heparin | http://purl.org/sig/ont/fma/fma82839 |
LitCovid-PubTator
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
|---|---|---|---|---|---|
| 446 | 409-414 | Gene | denotes | spike | Gene:43740568 |
| 447 | 552-557 | Gene | denotes | spike | Gene:43740568 |
| 448 | 169-174 | Gene | denotes | spike | Gene:43740568 |
| 449 | 48-58 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
| 450 | 158-168 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
| 451 | 97-104 | Chemical | denotes | heparin | MESH:D006493 |
| 452 | 137-144 | Chemical | denotes | heparin | MESH:D006493 |
| 453 | 299-307 | Chemical | denotes | heparins | MESH:D006493 |
| 454 | 350-378 | Chemical | denotes | low-molecular weight heparin | MESH:D006495 |
| 455 | 632-639 | Chemical | denotes | heparin | MESH:D006493 |
| 456 | 814-821 | Chemical | denotes | heparin | MESH:D006493 |
| 457 | 878-887 | Disease | denotes | infection | MESH:D007239 |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T116 | 48-56 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T117 | 48-52 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T118 | 158-166 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T119 | 158-162 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T120 | 878-887 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T64 | 199-200 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T65 | 523-531 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activity |
| T66 | 713-721 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activity |
| T67 | 938-946 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activity |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T130 | 97-104 | Chemical | denotes | heparin | http://purl.obolibrary.org/obo/CHEBI_28304 |
| T131 | 111-120 | Chemical | denotes | antiviral | http://purl.obolibrary.org/obo/CHEBI_22587 |
| T132 | 137-144 | Chemical | denotes | heparin | http://purl.obolibrary.org/obo/CHEBI_28304 |
| T133 | 175-182 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T134 | 213-222 | Chemical | denotes | inhibitor | http://purl.obolibrary.org/obo/CHEBI_35222 |
| T135 | 299-307 | Chemical | denotes | heparins | http://purl.obolibrary.org/obo/CHEBI_24505 |
| T136 | 371-378 | Chemical | denotes | heparin | http://purl.obolibrary.org/obo/CHEBI_28304 |
| T137 | 415-422 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T138 | 513-522 | Chemical | denotes | antiviral | http://purl.obolibrary.org/obo/CHEBI_22587 |
| T139 | 558-565 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T140 | 632-639 | Chemical | denotes | heparin | http://purl.obolibrary.org/obo/CHEBI_28304 |
| T141 | 703-712 | Chemical | denotes | antiviral | http://purl.obolibrary.org/obo/CHEBI_22587 |
| T142 | 753-766 | Chemical | denotes | anticoagulant | http://purl.obolibrary.org/obo/CHEBI_50249 |
| T143 | 814-821 | Chemical | denotes | heparin | http://purl.obolibrary.org/obo/CHEBI_28304 |
| T144 | 928-937 | Chemical | denotes | antiviral | http://purl.obolibrary.org/obo/CHEBI_22587 |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T78 | 0-121 | Sentence | denotes | Our developing understanding of the virology of SARS-CoV-2 suggests the biologic plausibility of heparin as an antiviral. |
| T79 | 122-268 | Sentence | denotes | Theoretically, heparin may bind the SARS-CoV-2 spike protein and function as a competitive inhibitor for viral entry, thus decreasing infectivity. |
| T80 | 269-574 | Sentence | denotes | Interestingly, shorter-length heparins, comparable to those found in therapeutic low-molecular weight heparin, did not appreciably bind the spike protein (17), suggesting that low-molecular weight formulations may be less likely to have direct antiviral activity through competitive spike protein binding. |
| T81 | 575-783 | Sentence | denotes | If clinical trials demonstrate benefit of unfractionated heparin therapy, its effect could be partially due to this theoretical antiviral activity, rather than solely due to its anticoagulant properties (38). |
| T82 | 784-947 | Sentence | denotes | As such, clinical trials with heparin should evaluate disease course and time to clearance of infection, as these outcomes would support direct antiviral activity. |
2_test
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| 32519894-32220112-2138182 | 779-781 | 32220112 | denotes | 38 |