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PMC:7381711 / 11017-12403 JSONTXT

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LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T73 85-92 Body_part denotes heparin http://purl.org/sig/ont/fma/fma82839
T74 325-329 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T75 433-440 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T76 619-631 Body_part denotes cell surface http://purl.org/sig/ont/fma/fma67653
T77 619-623 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T78 632-647 Body_part denotes heparan sulfate http://purl.org/sig/ont/fma/fma63023
T79 662-680 Body_part denotes glycosaminoglycans http://purl.org/sig/ont/fma/fma63011
T80 690-697 Body_part denotes heparin http://purl.org/sig/ont/fma/fma82839
T81 802-817 Body_part denotes Heparan sulfate http://purl.org/sig/ont/fma/fma63023
T82 802-809 Body_part denotes Heparan http://purl.org/sig/ont/fma/fma67110
T83 856-863 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T84 1095-1102 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T85 1123-1138 Body_part denotes heparan sulfate http://purl.org/sig/ont/fma/fma63023
T86 1206-1214 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T87 1271-1278 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T88 1346-1353 Body_part denotes heparin http://purl.org/sig/ont/fma/fma82839

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
404 449-480 Gene denotes angiotensin-converting enzyme 2 Gene:59272
405 482-486 Gene denotes ACE2 Gene:59272
406 980-984 Gene denotes ACE2 Gene:59272
407 1265-1270 Gene denotes spike Gene:43740568
408 1200-1205 Gene denotes spike Gene:43740568
409 1089-1094 Gene denotes spike Gene:43740568
410 850-855 Gene denotes spike Gene:43740568
411 427-432 Gene denotes spike Gene:43740568
412 96-104 Species denotes patients Tax:9606
413 236-247 Species denotes coronavirus Tax:11118
414 249-257 Species denotes SARS-CoV Tax:694009
415 263-318 Species denotes Middle East respiratory syndrome coronavirus (MERS-CoV) Tax:1335626
416 558-568 Species denotes SARS-CoV-2 Tax:2697049
417 755-777 Species denotes human coronavirus NL63 Tax:277944
418 787-795 Species denotes SARS-CoV Tax:694009
419 963-971 Species denotes SARS-CoV Tax:694009
420 1059-1072 Species denotes coronaviruses Tax:11118
421 1078-1088 Species denotes SARS-CoV-2 Tax:2697049
422 1179-1187 Species denotes SARS-CoV Tax:694009
423 1191-1199 Species denotes MERS-CoV Tax:1335626
424 1254-1264 Species denotes SARS-CoV-2 Tax:2697049
425 136-146 Species denotes SARS-CoV-2 Tax:2697049
426 85-92 Chemical denotes heparin MESH:D006493
427 632-647 Chemical denotes heparan sulfate MESH:D006497
428 690-697 Chemical denotes heparin MESH:D006493
429 802-817 Chemical denotes Heparan sulfate MESH:D006497
430 1123-1138 Chemical denotes heparan sulfate MESH:D006497
431 1346-1353 Chemical denotes heparin MESH:D006493
432 110-118 Disease denotes COVID-19 MESH:C000657245
433 381-401 Disease denotes SARS-CoV-2 infection MESH:C000657245

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T96 110-118 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T97 136-144 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T98 136-140 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T99 249-257 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T100 249-253 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T101 381-389 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T102 381-385 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T103 392-401 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T104 558-566 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T105 558-562 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T106 787-795 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T107 787-791 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T108 963-971 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T109 963-967 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T110 1078-1086 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T111 1078-1082 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T112 1179-1187 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T113 1179-1183 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T114 1254-1262 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T115 1254-1258 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T55 157-165 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T56 170-171 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T57 203-210 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T58 325-329 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T59 619-623 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T60 755-760 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T61 1003-1006 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T62 1149-1150 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T63 1292-1301 http://www.ebi.ac.uk/efo/EFO_0000876 denotes extremely

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T110 85-92 Chemical denotes heparin http://purl.obolibrary.org/obo/CHEBI_28304
T111 147-156 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T112 433-440 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T113 449-460 Chemical denotes angiotensin http://purl.obolibrary.org/obo/CHEBI_48433
T114 632-647 Chemical denotes heparan sulfate http://purl.obolibrary.org/obo/CHEBI_28815
T115 632-639 Chemical denotes heparan http://purl.obolibrary.org/obo/CHEBI_24500
T116 640-647 Chemical denotes sulfate http://purl.obolibrary.org/obo/CHEBI_16189
T117 662-680 Chemical denotes glycosaminoglycans http://purl.obolibrary.org/obo/CHEBI_18085
T118 690-697 Chemical denotes heparin http://purl.obolibrary.org/obo/CHEBI_28304
T119 802-817 Chemical denotes Heparan sulfate http://purl.obolibrary.org/obo/CHEBI_28815
T120 810-817 Chemical denotes sulfate http://purl.obolibrary.org/obo/CHEBI_16189
T121 856-863 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T122 879-887 Chemical denotes molecule http://purl.obolibrary.org/obo/CHEBI_25367
T123 1095-1102 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T124 1123-1138 Chemical denotes heparan sulfate http://purl.obolibrary.org/obo/CHEBI_28815
T125 1123-1130 Chemical denotes heparan http://purl.obolibrary.org/obo/CHEBI_24500
T126 1131-1138 Chemical denotes sulfate http://purl.obolibrary.org/obo/CHEBI_16189
T127 1206-1214 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T128 1271-1278 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T129 1346-1353 Chemical denotes heparin http://purl.obolibrary.org/obo/CHEBI_28304

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T9 325-336 http://purl.obolibrary.org/obo/GO_0140253 denotes cell fusion
T10 325-336 http://purl.obolibrary.org/obo/GO_0045026 denotes cell fusion
T11 325-336 http://purl.obolibrary.org/obo/GO_0000768 denotes cell fusion
T12 325-336 http://purl.obolibrary.org/obo/GO_0000747 denotes cell fusion

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T72 0-166 Sentence denotes Beyond anticoagulation, there may be alternative beneficial mechanisms of action for heparin in patients with COVID-19 including direct SARS-CoV-2 antiviral activity.
T73 167-498 Sentence denotes In a similar fashion to the related viruses severe acute respiratory coronavirus (SARS-CoV) and Middle East respiratory syndrome coronavirus (MERS-CoV), host cell fusion and entry are thought to be accomplished in SARS-CoV-2 infection via binding of the viral spike protein to host angiotensin-converting enzyme 2 (ACE2) receptors.
T74 499-801 Sentence denotes Cofactors for this binding are incompletely understood for SARS-CoV-2; however, in vitro studies have demonstrated that cell surface heparan sulfate (the class of glycosaminoglycans of which heparin is composed) is essential for entry and infectivity with human coronavirus NL63 (23) and SARS-CoV (19).
T75 802-999 Sentence denotes Heparan sulfate is thought to interact with the spike protein as an adhesion molecule coreceptor, which may be the first step in facilitating the interaction of SARS-CoV and the ACE2 receptor (23).
T76 1000-1220 Sentence denotes It has recently been discovered that concordant with other coronaviruses, the SARS-CoV-2 spike protein also interacts with heparan sulfate, and with a higher affinity than either SARS-CoV or MERS-CoV spike proteins (17).
T77 1221-1386 Sentence denotes In this study by Kim et al., the SARS-CoV-2 spike protein demonstrated extremely strong (and nearly irreversible) binding to heparin using surface plasmon resonance.

LitCovid-PD-GlycoEpitope

Id Subject Object Predicate Lexical cue glyco_epitope_db_id
T10 632-647 GlycoEpitope denotes heparan sulfate http://www.glycoepitope.jp/epitopes/EP0086
T11 802-817 GlycoEpitope denotes Heparan sulfate http://www.glycoepitope.jp/epitopes/EP0086
T12 1123-1138 GlycoEpitope denotes heparan sulfate http://www.glycoepitope.jp/epitopes/EP0086

2_test

Id Subject Object Predicate Lexical cue
32519894-29142129-2138179 779-781 29142129 denotes 23
32519894-21887302-2138180 797-799 21887302 denotes 19
32519894-29142129-2138181 995-997 29142129 denotes 23