> top > docs > PMC:7381711 > annotations

PMC:7381711 JSONTXT

Annnotations TAB JSON ListView MergeView

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T1 0-7 Body_part denotes Heparin http://purl.org/sig/ont/fma/fma82839
T2 77-84 Body_part denotes HEPARIN http://purl.org/sig/ont/fma/fma82839
T3 690-697 Body_part denotes heparin http://purl.org/sig/ont/fma/fma82839
T4 776-783 Body_part denotes heparin http://purl.org/sig/ont/fma/fma82839
T5 980-987 Body_part denotes heparin http://purl.org/sig/ont/fma/fma82839
T6 1002-1009 Body_part denotes heparin http://purl.org/sig/ont/fma/fma82839
T7 1220-1227 Body_part denotes heparin http://purl.org/sig/ont/fma/fma82839
T8 1397-1404 Body_part denotes heparin http://purl.org/sig/ont/fma/fma82839
T9 2235-2242 Body_part denotes heparin http://purl.org/sig/ont/fma/fma82839
T10 2268-2276 Body_part denotes heparins http://purl.org/sig/ont/fma/fma82839
T11 2311-2318 Body_part denotes heparin http://purl.org/sig/ont/fma/fma82839
T12 2524-2531 Body_part denotes heparin http://purl.org/sig/ont/fma/fma82839
T13 2674-2681 Body_part denotes heparin http://purl.org/sig/ont/fma/fma82839
T14 2813-2820 Body_part denotes heparin http://purl.org/sig/ont/fma/fma82839
T15 2912-2919 Body_part denotes heparin http://purl.org/sig/ont/fma/fma82839
T16 2953-2960 Body_part denotes HEPARIN http://purl.org/sig/ont/fma/fma82839
T17 2984-2991 Body_part denotes Heparin http://purl.org/sig/ont/fma/fma82839
T18 3055-3070 Body_part denotes heparan sulfate http://purl.org/sig/ont/fma/fma63023
T19 3072-3074 Body_part denotes HS http://purl.org/sig/ont/fma/fma63023
T20 3076-3094 Body_part denotes glycosaminoglycans http://purl.org/sig/ont/fma/fma63011
T21 3117-3127 Body_part denotes intestines http://purl.org/sig/ont/fma/fma7199
T22 3181-3183 Body_part denotes HS http://purl.org/sig/ont/fma/fma63023
T23 3184-3201 Body_part denotes glycosaminoglycan http://purl.org/sig/ont/fma/fma63011
T24 3217-3224 Body_part denotes heparin http://purl.org/sig/ont/fma/fma82839
T25 3316-3323 Body_part denotes heparin http://purl.org/sig/ont/fma/fma82839
T26 3387-3395 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T27 3441-3447 Body_part denotes serine http://purl.org/sig/ont/fma/fma82764
T28 3641-3643 Body_part denotes HS http://purl.org/sig/ont/fma/fma63023
T29 3746-3753 Body_part denotes heparin http://purl.org/sig/ont/fma/fma82839
T30 3754-3761 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T31 3914-3921 Body_part denotes heparin http://purl.org/sig/ont/fma/fma82839
T32 3989-3996 Body_part denotes heparin http://purl.org/sig/ont/fma/fma82839
T33 3998-4006 Body_part denotes Heparins http://purl.org/sig/ont/fma/fma82839
T34 4034-4049 Body_part denotes heparan sulfate http://purl.org/sig/ont/fma/fma63023
T35 4051-4053 Body_part denotes HS http://purl.org/sig/ont/fma/fma63023
T36 4055-4073 Body_part denotes glycosaminoglycans http://purl.org/sig/ont/fma/fma63011
T37 4080-4082 Body_part denotes HS http://purl.org/sig/ont/fma/fma63023
T38 4115-4127 Body_part denotes disaccharide http://purl.org/sig/ont/fma/fma82744
T39 4137-4156 Body_part denotes N-acetylglucosamine http://purl.org/sig/ont/fma/fma82787
T40 4170-4185 Body_part denotes glucuronic acid http://purl.org/sig/ont/fma/fma82798
T41 4187-4191 Body_part denotes GlcA http://purl.org/sig/ont/fma/fma82798
T42 4323-4330 Body_part denotes heparin http://purl.org/sig/ont/fma/fma82839
T43 4346-4348 Body_part denotes HS http://purl.org/sig/ont/fma/fma63023
T44 4421-4428 Body_part denotes heparin http://purl.org/sig/ont/fma/fma82839
T45 4441-4443 Body_part denotes HS http://purl.org/sig/ont/fma/fma63023
T46 4510-4517 Body_part denotes heparin http://purl.org/sig/ont/fma/fma82839
T47 4615-4622 Body_part denotes heparin http://purl.org/sig/ont/fma/fma82839
T48 4626-4632 Body_part denotes serine http://purl.org/sig/ont/fma/fma82764
T49 4772-4779 Body_part denotes heparin http://purl.org/sig/ont/fma/fma82839
T50 4877-4885 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T51 5188-5193 Body_part denotes serum http://purl.org/sig/ont/fma/fma63083
T52 5407-5415 Body_part denotes alveolar http://purl.org/sig/ont/fma/fma264783
T53 5416-5425 Body_part denotes capillary http://purl.org/sig/ont/fma/fma63194
T54 6886-6891 Body_part denotes organ http://purl.org/sig/ont/fma/fma67498
T55 7158-7164 Body_part denotes tissue http://purl.org/sig/ont/fma/fma9637
T56 7209-7216 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T57 7558-7562 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T58 8077-8084 Body_part denotes HEPARIN http://purl.org/sig/ont/fma/fma82839
T59 8291-8298 Body_part denotes heparin http://purl.org/sig/ont/fma/fma82839
T60 8344-8351 Body_part denotes heparin http://purl.org/sig/ont/fma/fma82839
T61 8615-8622 Body_part denotes heparin http://purl.org/sig/ont/fma/fma82839
T62 8745-8752 Body_part denotes heparin http://purl.org/sig/ont/fma/fma82839
T63 8910-8917 Body_part denotes heparin http://purl.org/sig/ont/fma/fma82839
T64 9018-9024 Body_part denotes tissue http://purl.org/sig/ont/fma/fma9637
T65 9391-9398 Body_part denotes heparin http://purl.org/sig/ont/fma/fma82839
T66 10159-10166 Body_part denotes heparin http://purl.org/sig/ont/fma/fma82839
T67 10253-10263 Body_part denotes lymphocyte http://purl.org/sig/ont/fma/fma62863
T68 10285-10296 Body_part denotes interleukin http://purl.org/sig/ont/fma/fma86578
T69 10298-10300 Body_part denotes IL http://purl.org/sig/ont/fma/fma86578
T70 10390-10397 Body_part denotes heparin http://purl.org/sig/ont/fma/fma82839
T71 10628-10635 Body_part denotes heparin http://purl.org/sig/ont/fma/fma82839
T72 10983-10990 Body_part denotes HEPARIN http://purl.org/sig/ont/fma/fma82839
T73 11102-11109 Body_part denotes heparin http://purl.org/sig/ont/fma/fma82839
T74 11342-11346 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T75 11450-11457 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T76 11636-11648 Body_part denotes cell surface http://purl.org/sig/ont/fma/fma67653
T77 11636-11640 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T78 11649-11664 Body_part denotes heparan sulfate http://purl.org/sig/ont/fma/fma63023
T79 11679-11697 Body_part denotes glycosaminoglycans http://purl.org/sig/ont/fma/fma63011
T80 11707-11714 Body_part denotes heparin http://purl.org/sig/ont/fma/fma82839
T81 11819-11834 Body_part denotes Heparan sulfate http://purl.org/sig/ont/fma/fma63023
T82 11819-11826 Body_part denotes Heparan http://purl.org/sig/ont/fma/fma67110
T83 11873-11880 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T84 12112-12119 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T85 12140-12155 Body_part denotes heparan sulfate http://purl.org/sig/ont/fma/fma63023
T86 12223-12231 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T87 12288-12295 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T88 12363-12370 Body_part denotes heparin http://purl.org/sig/ont/fma/fma82839
T89 12501-12508 Body_part denotes heparin http://purl.org/sig/ont/fma/fma82839
T90 12541-12548 Body_part denotes heparin http://purl.org/sig/ont/fma/fma82839
T91 12579-12586 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T92 12703-12711 Body_part denotes heparins http://purl.org/sig/ont/fma/fma82839
T93 12775-12782 Body_part denotes heparin http://purl.org/sig/ont/fma/fma82839
T94 12819-12826 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T95 12962-12969 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T96 13036-13043 Body_part denotes heparin http://purl.org/sig/ont/fma/fma82839
T97 13218-13225 Body_part denotes heparin http://purl.org/sig/ont/fma/fma82839
T98 13414-13421 Body_part denotes heparin http://purl.org/sig/ont/fma/fma82839
T99 13490-13497 Body_part denotes heparin http://purl.org/sig/ont/fma/fma82839
T100 13508-13526 Body_part denotes glycosaminoglycans http://purl.org/sig/ont/fma/fma63011
T101 13627-13642 Body_part denotes heparan sulfate http://purl.org/sig/ont/fma/fma63023
T102 13950-13957 Body_part denotes heparin http://purl.org/sig/ont/fma/fma82839
T103 13962-13969 Body_part denotes heparin http://purl.org/sig/ont/fma/fma82839
T104 14072-14079 Body_part denotes HEPARIN http://purl.org/sig/ont/fma/fma82839
T105 14114-14121 Body_part denotes Heparin http://purl.org/sig/ont/fma/fma82839
T106 14177-14188 Body_part denotes vasculature http://purl.org/sig/ont/fma/fma69050
T107 14274-14281 Body_part denotes Heparin http://purl.org/sig/ont/fma/fma82839
T108 14326-14334 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T109 14371-14373 Body_part denotes IL http://purl.org/sig/ont/fma/fma86578
T110 14377-14385 Body_part denotes platelet http://purl.org/sig/ont/fma/fma62851
T111 14437-14447 Body_part denotes neutrophil http://purl.org/sig/ont/fma/fma62860
T112 14465-14475 Body_part denotes L-selectin http://purl.org/sig/ont/fma/fma62931
T113 14501-14508 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T114 14510-14513 Body_part denotes MBP http://purl.org/sig/ont/fma/fma242151
T115 14520-14530 Body_part denotes eosinophil http://purl.org/sig/ont/fma/fma62861
T116 14540-14547 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T117 14596-14603 Body_part denotes heparin http://purl.org/sig/ont/fma/fma82839
T118 14624-14639 Body_part denotes heparan sulfate http://purl.org/sig/ont/fma/fma63023
T119 14640-14657 Body_part denotes glycosaminoglycan http://purl.org/sig/ont/fma/fma63011
T120 14772-14780 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T121 14838-14843 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T122 14922-14929 Body_part denotes heparin http://purl.org/sig/ont/fma/fma82839
T123 15285-15294 Body_part denotes cytokines http://purl.org/sig/ont/fma/fma84050
T124 15321-15329 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T125 15373-15377 Body_part denotes IL-1 http://purl.org/sig/ont/fma/fma86583
T126 15373-15375 Body_part denotes IL http://purl.org/sig/ont/fma/fma86578
T127 15380-15382 Body_part denotes IL http://purl.org/sig/ont/fma/fma86578
T128 15390-15392 Body_part denotes IL http://purl.org/sig/ont/fma/fma86578
T129 15405-15412 Body_part denotes Heparin http://purl.org/sig/ont/fma/fma82839
T130 15490-15507 Body_part denotes endothelial cells http://purl.org/sig/ont/fma/fma66772
T131 15502-15507 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T132 15518-15527 Body_part denotes monocytes http://purl.org/sig/ont/fma/fma62864
T133 15557-15564 Body_part denotes heparin http://purl.org/sig/ont/fma/fma82839
T134 15789-15793 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T135 15880-15887 Body_part denotes heparin http://purl.org/sig/ont/fma/fma82839
T136 15924-15941 Body_part denotes endothelial cells http://purl.org/sig/ont/fma/fma66772
T137 15936-15941 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T138 15987-16000 Body_part denotes immune system http://purl.org/sig/ont/fma/fma9825
T139 16026-16036 Body_part denotes neutrophil http://purl.org/sig/ont/fma/fma62860
T140 16068-16075 Body_part denotes heparin http://purl.org/sig/ont/fma/fma82839
T141 16247-16254 Body_part denotes heparin http://purl.org/sig/ont/fma/fma82839
T142 16364-16369 Body_part denotes bowel http://purl.org/sig/ont/fma/fma7199
T143 16483-16490 Body_part denotes heparin http://purl.org/sig/ont/fma/fma82839
T144 16653-16660 Body_part denotes HEPARIN http://purl.org/sig/ont/fma/fma82839
T145 16680-16687 Body_part denotes heparin http://purl.org/sig/ont/fma/fma82839
T146 16958-16974 Body_part denotes white blood cell http://purl.org/sig/ont/fma/fma62852
T147 16970-16974 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T148 16979-16987 Body_part denotes platelet http://purl.org/sig/ont/fma/fma62851
T149 17129-17136 Body_part denotes heparin http://purl.org/sig/ont/fma/fma82839
T150 17215-17222 Body_part denotes heparin http://purl.org/sig/ont/fma/fma82839
T151 17314-17321 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T152 17322-17330 Body_part denotes platelet http://purl.org/sig/ont/fma/fma62851
T153 17481-17488 Body_part denotes heparin http://purl.org/sig/ont/fma/fma82839
T154 17527-17531 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T155 17725-17729 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T156 17823-17827 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T157 17942-17959 Body_part denotes epithelial tissue http://purl.org/sig/ont/fma/fma9639
T158 18064-18070 Body_part denotes tissue http://purl.org/sig/ont/fma/fma9637
T159 18170-18178 Body_part denotes alveolar http://purl.org/sig/ont/fma/fma264783
T160 18340-18348 Body_part denotes alveolar http://purl.org/sig/ont/fma/fma264783
T161 18455-18462 Body_part denotes heparin http://purl.org/sig/ont/fma/fma82839
T162 18524-18531 Body_part denotes heparin http://purl.org/sig/ont/fma/fma82839
T163 18668-18675 Body_part denotes heparin http://purl.org/sig/ont/fma/fma82839
T164 18749-18767 Body_part denotes intestinal mucosae http://purl.org/sig/ont/fma/fma15695
T165 18769-18784 Body_part denotes heparan sulfate http://purl.org/sig/ont/fma/fma63023
T166 18785-18800 Body_part denotes polysaccharides http://purl.org/sig/ont/fma/fma82746
T167 19039-19046 Body_part denotes heparin http://purl.org/sig/ont/fma/fma82839
T168 19108-19113 Body_part denotes organ http://purl.org/sig/ont/fma/fma67498
T169 19138-19143 Body_part denotes organ http://purl.org/sig/ont/fma/fma67498
T170 19252-19259 Body_part denotes heparin http://purl.org/sig/ont/fma/fma82839
T171 19481-19488 Body_part denotes heparin http://purl.org/sig/ont/fma/fma82839
T172 19749-19756 Body_part denotes heparin http://purl.org/sig/ont/fma/fma82839
T173 19890-19897 Body_part denotes heparin http://purl.org/sig/ont/fma/fma82839
T174 19984-19991 Body_part denotes heparin http://purl.org/sig/ont/fma/fma82839
T175 20035-20044 Body_part denotes Heparin’s http://purl.org/sig/ont/fma/fma82839
T176 20354-20370 Body_part denotes epithelial cells http://purl.org/sig/ont/fma/fma66768
T177 20365-20370 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T178 20423-20435 Body_part denotes cell surface http://purl.org/sig/ont/fma/fma67653
T179 20423-20427 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T180 20436-20451 Body_part denotes heparan sulfate http://purl.org/sig/ont/fma/fma63023
T181 20459-20466 Body_part denotes heparin http://purl.org/sig/ont/fma/fma82839
T182 20500-20507 Body_part denotes heparin http://purl.org/sig/ont/fma/fma82839
T183 20581-20588 Body_part denotes heparin http://purl.org/sig/ont/fma/fma82839
T184 20787-20794 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T185 20798-20800 Body_part denotes HS http://purl.org/sig/ont/fma/fma63023
T186 20802-20817 Body_part denotes heparan sulfate http://purl.org/sig/ont/fma/fma63023
T187 20819-20821 Body_part denotes IL http://purl.org/sig/ont/fma/fma86578
T188 20823-20834 Body_part denotes interleukin http://purl.org/sig/ont/fma/fma86578
T189 20882-20888 Body_part denotes tissue http://purl.org/sig/ont/fma/fma9637
T190 20903-20909 Body_part denotes tissue http://purl.org/sig/ont/fma/fma9637
T191 20969-20975 Body_part denotes tissue http://purl.org/sig/ont/fma/fma9637

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 3117-3127 Body_part denotes intestines http://purl.obolibrary.org/obo/UBERON_0000160
T2 5188-5193 Body_part denotes serum http://purl.obolibrary.org/obo/UBERON_0001977
T3 5416-5425 Body_part denotes capillary http://purl.obolibrary.org/obo/UBERON_0001982
T4 5777-5783 Body_part denotes vessel http://purl.obolibrary.org/obo/UBERON_0000055
T5 6164-6170 Body_part denotes vessel http://purl.obolibrary.org/obo/UBERON_0000055
T6 6886-6891 Body_part denotes organ http://purl.obolibrary.org/obo/UBERON_0000062
T7 7158-7164 Body_part denotes tissue http://purl.obolibrary.org/obo/UBERON_0000479
T8 7558-7562 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T9 9018-9024 Body_part denotes tissue http://purl.obolibrary.org/obo/UBERON_0000479
T10 14177-14188 Body_part denotes vasculature http://purl.obolibrary.org/obo/UBERON_0002049
T11 15987-16000 Body_part denotes immune system http://purl.obolibrary.org/obo/UBERON_0002405
T12 16964-16969 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T13 17527-17531 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T14 17725-17729 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T15 17823-17827 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T16 17953-17959 Body_part denotes tissue http://purl.obolibrary.org/obo/UBERON_0000479
T17 18064-18070 Body_part denotes tissue http://purl.obolibrary.org/obo/UBERON_0000479
T18 18749-18767 Body_part denotes intestinal mucosae http://purl.obolibrary.org/obo/UBERON_0001242
T19 19108-19113 Body_part denotes organ http://purl.obolibrary.org/obo/UBERON_0000062
T20 19138-19143 Body_part denotes organ http://purl.obolibrary.org/obo/UBERON_0000062
T21 20882-20888 Body_part denotes tissue http://purl.obolibrary.org/obo/UBERON_0000479
T22 20903-20909 Body_part denotes tissue http://purl.obolibrary.org/obo/UBERON_0000479
T23 20969-20975 Body_part denotes tissue http://purl.obolibrary.org/obo/UBERON_0000479

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
2 0-7 Chemical denotes Heparin MESH:D006493
3 25-33 Disease denotes COVID-19 MESH:C000657245
24 195-242 Species denotes severe acute respiratory syndrome coronavirus 2 Tax:2697049
25 244-254 Species denotes SARS-CoV-2 Tax:2697049
26 583-591 Species denotes patients Tax:9606
27 690-697 Chemical denotes heparin MESH:D006493
28 776-783 Chemical denotes heparin MESH:D006493
29 980-987 Chemical denotes heparin MESH:D006493
30 1002-1009 Chemical denotes heparin MESH:D006493
31 1220-1227 Chemical denotes heparin MESH:D006493
32 1397-1404 Chemical denotes heparin MESH:D006493
33 107-131 Disease denotes Coronavirus disease 2019 MESH:C000657245
34 133-141 Disease denotes COVID-19 MESH:C000657245
35 182-191 Disease denotes infection MESH:D007239
36 561-579 Disease denotes hypercoagulability MESH:D019851
37 597-605 Disease denotes COVID-19 MESH:C000657245
38 872-892 Disease denotes SARS-CoV-2 infection MESH:C000657245
39 1038-1046 Disease denotes COVID-19 MESH:C000657245
40 1189-1199 Disease denotes enthusiasm
41 1244-1252 Disease denotes COVID-19 MESH:C000657245
42 1363-1379 Disease denotes critical illness MESH:D016638
43 1409-1417 Disease denotes COVID-19 MESH:C000657245
53 1561-1577 Species denotes Coronavirus 2019 Tax:2697049
54 1635-1682 Species denotes severe acute respiratory syndrome coronavirus 2 Tax:2697049
55 1684-1694 Species denotes SARS-CoV-2 Tax:2697049
56 1811-1820 Species denotes influenza Tax:11320
57 2235-2242 Chemical denotes heparin MESH:D006493
58 2247-2276 Chemical denotes low-molecular weight heparins MESH:D006495
59 2311-2318 Chemical denotes heparin MESH:D006493
60 1579-1587 Disease denotes COVID-19 MESH:C000657245
61 1618-1627 Disease denotes infection MESH:D007239
72 2842-2852 Species denotes SARS-CoV-2 Tax:2697049
73 2524-2531 Chemical denotes heparin MESH:D006493
74 2674-2681 Chemical denotes heparin MESH:D006493
75 2813-2820 Chemical denotes heparin MESH:D006493
76 2912-2919 Chemical denotes heparin MESH:D006493
77 2607-2615 Disease denotes COVID-19 MESH:C000657245
78 2729-2737 Disease denotes COVID-19 MESH:C000657245
79 2883-2891 Disease denotes bleeding MESH:D006470
80 2928-2944 Disease denotes thrombocytopenia MESH:D013921
81 2946-2949 Disease denotes HIT MESH:D013921
83 2953-2960 Chemical denotes HEPARIN MESH:D006493
97 3485-3488 Gene denotes AT3 Gene:462
98 3667-3670 Gene denotes AT3 Gene:462
99 3706-3709 Gene denotes AT3 Gene:462
100 3467-3483 Gene denotes antithrombin-III Gene:462
101 2984-2991 Chemical denotes Heparin MESH:D006493
102 3055-3094 Chemical denotes heparan sulfate (HS) glycosaminoglycans
103 3181-3201 Chemical denotes HS glycosaminoglycan
104 3217-3224 Chemical denotes heparin MESH:D006493
105 3316-3323 Chemical denotes heparin MESH:D006493
106 3441-3447 Chemical denotes serine MESH:D012694
107 3602-3617 Chemical denotes pentasaccharide
108 3746-3753 Chemical denotes heparin MESH:D006493
109 3914-3921 Chemical denotes heparin MESH:D006493
131 4652-4668 Gene denotes antithrombin-III Gene:462
132 4670-4673 Gene denotes AT3 Gene:462
133 3989-3996 Chemical denotes heparin MESH:D006493
134 3998-4006 Chemical denotes Heparins MESH:D006493
135 4034-4049 Chemical denotes heparan sulfate MESH:D006497
136 4051-4073 Chemical denotes HS) glycosaminoglycans
137 4115-4127 Chemical denotes disaccharide MESH:D004187
138 4137-4156 Chemical denotes N-acetylglucosamine MESH:D000117
139 4158-4164 Chemical denotes GlcNAc MESH:D000117
140 4170-4185 Chemical denotes glucuronic acid MESH:D020723
141 4187-4191 Chemical denotes GlcA MESH:D020723
142 4196-4209 Chemical denotes iduronic acid MESH:D007067
143 4211-4215 Chemical denotes IdoA MESH:D007067
144 4218-4224 Chemical denotes GlcNAc MESH:D000117
145 4323-4330 Chemical denotes heparin MESH:D006493
146 4400-4428 Chemical denotes low-molecular weight heparin MESH:D006495
147 4510-4517 Chemical denotes heparin MESH:D006493
148 4558-4573 Chemical denotes pentasaccharide
149 4615-4622 Chemical denotes heparin MESH:D006493
150 4626-4632 Chemical denotes serine MESH:D012694
151 4772-4779 Chemical denotes heparin MESH:D006493
153 4919-4927 Disease denotes COVID-19 MESH:C000657245
167 4933-4941 Species denotes patients Tax:9606
168 5325-5333 Species denotes patients Tax:9606
169 5478-5488 Species denotes SARS-CoV-2 Tax:2697049
170 4947-4955 Disease denotes COVID-19 MESH:C000657245
171 4989-5001 Disease denotes coagulopathy MESH:D001778
172 5015-5027 Disease denotes coagulopathy MESH:D001778
173 5044-5052 Disease denotes COVID-19 MESH:C000657245
174 5073-5089 Disease denotes thrombocytopenia MESH:D013921
175 5248-5260 Disease denotes coagulopathy MESH:D001778
176 5339-5347 Disease denotes COVID-19 MESH:C000657245
177 5366-5384 Disease denotes endothelial injury MESH:D014947
178 5386-5401 Disease denotes microangiopathy MESH:D000783
179 5407-5456 Disease denotes alveolar capillary microthrombi (2) Endotheliitis MESH:C536590
205 5693-5701 Species denotes patients Tax:9606
206 5871-5879 Species denotes patients Tax:9606
207 6084-6092 Species denotes patients Tax:9606
208 6098-6102 Species denotes H1N1 Tax:114727
209 6182-6190 Species denotes patients Tax:9606
210 6242-6252 Species denotes SARS-CoV-2 Tax:2697049
211 6330-6338 Species denotes patients Tax:9606
212 6103-6112 Species denotes influenza Tax:11320
213 5617-5639 Disease denotes disordered coagulation MESH:D001778
214 5644-5662 Disease denotes endothelial injury MESH:D014947
215 5707-5715 Disease denotes COVID-19 MESH:C000657245
216 5784-5794 Disease denotes thrombosis MESH:D013927
217 5824-5846 Disease denotes venous thromboembolism MESH:D054556
218 5848-5851 Disease denotes VTE MESH:D054556
219 5856-5870 Disease denotes critically ill MESH:D016638
220 5948-5951 Disease denotes VTE MESH:D054556
221 5955-5963 Disease denotes COVID-19 MESH:C000657245
222 6069-6083 Disease denotes critically ill MESH:D016638
223 6128-6134 Disease denotes sepsis MESH:D018805
224 6171-6178 Disease denotes strokes MESH:D020521
225 6228-6236 Disease denotes infected MESH:D007239
226 6266-6284 Disease denotes hypercoagulability MESH:D019851
227 6352-6360 Disease denotes COVID-19 MESH:C000657245
228 6367-6377 Disease denotes thrombosis MESH:D013927
229 6440-6446 Disease denotes deaths MESH:D003643
249 7127-7141 Gene denotes thrombomodulin Gene:7056
250 7158-7189 Gene denotes tissue factor pathway inhibitor Gene:7035
251 7148-7151 Gene denotes AT3 Gene:462
252 7009-7017 Species denotes patients Tax:9606
253 6487-6495 Disease denotes COVID-19 MESH:C000657245
254 6507-6534 Disease denotes coagulopathy and thromboses MESH:D013927
255 6567-6591 Disease denotes mortality of the disease MESH:D003643
256 6646-6654 Disease denotes COVID-19 MESH:C000657245
257 6712-6724 Disease denotes coagulopathy MESH:D001778
258 6826-6838 Disease denotes coagulopathy MESH:D001778
259 6886-6899 Disease denotes organ failure MESH:D009102
260 6903-6909 Disease denotes sepsis MESH:D018805
261 7023-7031 Disease denotes COVID-19 MESH:C000657245
262 7099-7111 Disease denotes coagulopathy MESH:D001778
263 7115-7121 Disease denotes sepsis MESH:D018805
264 7251-7260 Disease denotes mortality MESH:D003643
265 7302-7314 Disease denotes coagulopathy MESH:D001778
266 7343-7355 Disease denotes coagulopathy MESH:D001778
267 7387-7393 Disease denotes sepsis MESH:D018805
275 8032-8040 Species denotes patients Tax:9606
276 7641-7663 Disease denotes Coagulopathy in sepsis MESH:D018805
277 7678-7702 Disease denotes coronavirus disease 2019 MESH:C000657245
278 7704-7712 Disease denotes COVID-19 MESH:C000657245
279 7758-7770 Disease denotes coagulopathy MESH:D001778
280 7834-7840 Disease denotes sepsis MESH:D018805
281 7845-7853 Disease denotes COVID-19 MESH:C000657245
284 8077-8084 Chemical denotes HEPARIN MESH:D006493
285 8108-8116 Disease denotes COVID-19 MESH:C000657245
310 9018-9046 Gene denotes tissue plasminogen activator Gene:100128998
311 8311-8318 Species denotes patient Tax:9606
312 8435-8443 Species denotes patients Tax:9606
313 8506-8514 Species denotes patients Tax:9606
314 8594-8602 Species denotes patients Tax:9606
315 8754-8762 Species denotes Patients Tax:9606
316 8948-8956 Species denotes patients Tax:9606
317 8291-8298 Chemical denotes heparin MESH:D006493
318 8344-8351 Chemical denotes heparin MESH:D006493
319 8615-8622 Chemical denotes heparin MESH:D006493
320 8745-8752 Chemical denotes heparin MESH:D006493
321 8910-8917 Chemical denotes heparin MESH:D006493
322 8156-8172 Disease denotes critical illness MESH:D016638
323 8217-8229 Disease denotes coagulopathy MESH:D001778
324 8248-8251 Disease denotes VTE MESH:D054556
325 8255-8263 Disease denotes COVID-19 MESH:C000657245
326 8375-8383 Disease denotes COVID-19 MESH:C000657245
327 8449-8457 Disease denotes COVID-19 MESH:C000657245
328 8564-8567 Disease denotes VTE MESH:D054556
329 8848-8875 Disease denotes sepsis-induced coagulopathy MESH:D018805
330 8933-8942 Disease denotes mortality MESH:D003643
331 9110-9118 Disease denotes COVID-19 MESH:C000657245
332 9127-9162 Disease denotes acute respiratory distress syndrome MESH:D012128
333 9197-9207 Disease denotes thrombosis MESH:D013927
352 10285-10303 Gene denotes interleukin (IL)-6 Gene:3569
353 9492-9500 Species denotes patients Tax:9606
354 9557-9565 Species denotes patients Tax:9606
355 9727-9735 Species denotes patients Tax:9606
356 9808-9816 Species denotes patients Tax:9606
357 10130-10138 Species denotes patients Tax:9606
358 10405-10413 Species denotes patients Tax:9606
359 9391-9398 Chemical denotes heparin MESH:D006493
360 10159-10166 Chemical denotes heparin MESH:D006493
361 10390-10397 Chemical denotes heparin MESH:D006493
362 10628-10635 Chemical denotes heparin MESH:D006493
363 9402-9410 Disease denotes COVID-19 MESH:C000657245
364 9506-9514 Disease denotes COVID-19 MESH:C000657245
365 9684-9693 Disease denotes mortality MESH:D003643
366 10414-10422 Disease denotes infected MESH:D007239
367 10428-10436 Disease denotes COVID-19 MESH:C000657245
368 10571-10579 Disease denotes COVID-19 MESH:C000657245
369 10947-10955 Disease denotes COVID-19 MESH:C000657245
372 10996-11006 Species denotes SARS-CoV-2 Tax:2697049
373 10983-10990 Chemical denotes HEPARIN MESH:D006493
404 11466-11497 Gene denotes angiotensin-converting enzyme 2 Gene:59272
405 11499-11503 Gene denotes ACE2 Gene:59272
406 11997-12001 Gene denotes ACE2 Gene:59272
407 12282-12287 Gene denotes spike Gene:43740568
408 12217-12222 Gene denotes spike Gene:43740568
409 12106-12111 Gene denotes spike Gene:43740568
410 11867-11872 Gene denotes spike Gene:43740568
411 11444-11449 Gene denotes spike Gene:43740568
412 11113-11121 Species denotes patients Tax:9606
413 11253-11264 Species denotes coronavirus Tax:11118
414 11266-11274 Species denotes SARS-CoV Tax:694009
415 11280-11335 Species denotes Middle East respiratory syndrome coronavirus (MERS-CoV) Tax:1335626
416 11575-11585 Species denotes SARS-CoV-2 Tax:2697049
417 11772-11794 Species denotes human coronavirus NL63 Tax:277944
418 11804-11812 Species denotes SARS-CoV Tax:694009
419 11980-11988 Species denotes SARS-CoV Tax:694009
420 12076-12089 Species denotes coronaviruses Tax:11118
421 12095-12105 Species denotes SARS-CoV-2 Tax:2697049
422 12196-12204 Species denotes SARS-CoV Tax:694009
423 12208-12216 Species denotes MERS-CoV Tax:1335626
424 12271-12281 Species denotes SARS-CoV-2 Tax:2697049
425 11153-11163 Species denotes SARS-CoV-2 Tax:2697049
426 11102-11109 Chemical denotes heparin MESH:D006493
427 11649-11664 Chemical denotes heparan sulfate MESH:D006497
428 11707-11714 Chemical denotes heparin MESH:D006493
429 11819-11834 Chemical denotes Heparan sulfate MESH:D006497
430 12140-12155 Chemical denotes heparan sulfate MESH:D006497
431 12363-12370 Chemical denotes heparin MESH:D006493
432 11127-11135 Disease denotes COVID-19 MESH:C000657245
433 11398-11418 Disease denotes SARS-CoV-2 infection MESH:C000657245
446 12813-12818 Gene denotes spike Gene:43740568
447 12956-12961 Gene denotes spike Gene:43740568
448 12573-12578 Gene denotes spike Gene:43740568
449 12452-12462 Species denotes SARS-CoV-2 Tax:2697049
450 12562-12572 Species denotes SARS-CoV-2 Tax:2697049
451 12501-12508 Chemical denotes heparin MESH:D006493
452 12541-12548 Chemical denotes heparin MESH:D006493
453 12703-12711 Chemical denotes heparins MESH:D006493
454 12754-12782 Chemical denotes low-molecular weight heparin MESH:D006495
455 13036-13043 Chemical denotes heparin MESH:D006493
456 13218-13225 Chemical denotes heparin MESH:D006493
457 13282-13291 Disease denotes infection MESH:D007239
471 13708-13713 Species denotes human Tax:9606
472 13714-13727 Species denotes coronaviruses Tax:11118
473 13757-13774 Species denotes hepatitis C virus Tax:11103
474 13779-13790 Species denotes herpesvirus Tax:39059
475 14001-14014 Species denotes coronaviruses Tax:11118
476 13414-13421 Chemical denotes heparin MESH:D006493
477 13490-13497 Chemical denotes heparin MESH:D006493
478 13508-13526 Chemical denotes glycosaminoglycans MESH:D006025
479 13627-13642 Chemical denotes heparan sulfate MESH:D006497
480 13950-13957 Chemical denotes heparin MESH:D006493
481 13962-13969 Chemical denotes heparin MESH:D006493
482 13892-13900 Disease denotes COVID-19 MESH:C000657245
483 13992-14000 Disease denotes zoonotic MESH:D015047
486 14072-14079 Chemical denotes HEPARIN MESH:D006493
487 14105-14113 Disease denotes COVID-19 MESH:C000657245
506 14371-14375 Gene denotes IL-8 Gene:3576
507 14437-14456 Gene denotes neutrophil elastase Gene:1991
508 14458-14475 Gene denotes P- and L-selectin Gene:6403
509 14477-14482 Gene denotes CD11b Gene:3684
510 14483-14487 Gene denotes CD18 Gene:4055
511 14489-14508 Gene denotes major basic protein Gene:4155
512 14510-14513 Gene denotes MBP Gene:4155
513 14520-14547 Gene denotes eosinophil cationic protein Gene:6037
514 14549-14552 Gene denotes ECP Gene:6037
515 14114-14121 Chemical denotes Heparin MESH:D006493
516 14274-14281 Chemical denotes Heparin MESH:D006493
517 14403-14407 Chemical denotes PGF4
518 14596-14603 Chemical denotes heparin MESH:D006493
519 14624-14657 Chemical denotes heparan sulfate glycosaminoglycan
520 14240-14248 Disease denotes COVID-19 MESH:C000657245
521 14260-14272 Disease denotes inflammation MESH:D007249
522 14348-14360 Disease denotes inflammation MESH:D007249
523 14718-14730 Disease denotes inflammation MESH:D007249
547 15340-15363 Gene denotes tumor necrosis factor-α Gene:7124
548 15365-15370 Gene denotes TNF-α Gene:7124
549 15373-15378 Gene denotes IL-1β Gene:3552
550 15380-15384 Gene denotes IL-6 Gene:3569
551 15390-15394 Gene denotes IL-8 Gene:3576
552 15620-15645 Gene denotes high mobility group box 1 Gene:3146
553 15647-15652 Gene denotes HMGB1 Gene:3146
554 15138-15146 Species denotes SARS-CoV Tax:694009
555 15484-15489 Species denotes human Tax:9606
556 15512-15517 Species denotes human Tax:9606
557 14922-14929 Chemical denotes heparin MESH:D006493
558 15405-15412 Chemical denotes Heparin MESH:D006493
559 15469-15472 Chemical denotes LPS MESH:D008070
560 15557-15564 Chemical denotes heparin MESH:D006493
561 15880-15887 Chemical denotes heparin MESH:D006493
562 16068-16075 Chemical denotes heparin MESH:D006493
563 14941-14953 Disease denotes inflammation MESH:D007249
564 15737-15753 Disease denotes viral infections MESH:D001102
565 15862-15870 Disease denotes COVID-19 MESH:C000657245
566 16101-16113 Disease denotes inflammation MESH:D007249
567 16166-16178 Disease denotes inflammation MESH:D007249
568 16189-16201 Disease denotes pancreatitis MESH:D010195
569 16211-16217 Disease denotes sepsis MESH:D018805
576 16326-16331 Species denotes human Tax:9606
577 16247-16254 Chemical denotes heparin MESH:D006493
578 16483-16490 Chemical denotes heparin MESH:D006493
579 16351-16377 Disease denotes inflammatory bowel disease MESH:D015212
580 16379-16385 Disease denotes asthma MESH:D001249
581 16417-16440 Disease denotes acute coronary syndrome MESH:D054058
583 16653-16660 Chemical denotes HEPARIN MESH:D006493
598 17066-17074 Species denotes patients Tax:9606
599 17194-17202 Species denotes patients Tax:9606
600 16680-16687 Chemical denotes heparin MESH:D006493
601 17129-17136 Chemical denotes heparin MESH:D006493
602 17215-17222 Chemical denotes heparin MESH:D006493
603 16767-16775 Disease denotes bleeding MESH:D006470
604 16812-16820 Disease denotes bleeding MESH:D006470
605 16872-16878 Disease denotes trauma MESH:D014947
606 16948-16974 Disease denotes decreased white blood cell MESH:D007022
607 17036-17044 Disease denotes bleeding MESH:D006470
608 17080-17088 Disease denotes COVID-19 MESH:C000657245
609 17148-17151 Disease denotes HIT MESH:D013921
610 17373-17389 Disease denotes thrombocytopenia MESH:D013921
611 17421-17431 Disease denotes thrombosis MESH:D013927
628 18064-18077 Gene denotes tissue factor Gene:2152
629 17953-17966 Gene denotes tissue factor Gene:2152
630 18008-18017 Species denotes influenza Tax:11320
631 18108-18117 Species denotes influenza Tax:11320
632 17481-17488 Chemical denotes heparin MESH:D006493
633 18455-18462 Chemical denotes heparin MESH:D006493
634 17602-17610 Disease denotes COVID-19 MESH:C000657245
635 17621-17637 Disease denotes critical illness MESH:D016638
636 17649-17673 Disease denotes intravascular thrombosis MESH:D013927
637 17725-17736 Disease denotes lung injury MESH:D055370
638 17897-17912 Disease denotes viral pneumonia
639 17992-18001 Disease denotes mortality MESH:D003643
640 18018-18027 Disease denotes infection MESH:D007239
641 18297-18306 Disease denotes infection MESH:D007239
642 18353-18378 Disease denotes intravascular coagulation MESH:D004211
643 18504-18513 Disease denotes pneumonia MESH:D011014
650 18884-18887 Gene denotes AT3 Gene:462
651 18524-18531 Chemical denotes heparin MESH:D006493
652 18668-18675 Chemical denotes heparin MESH:D006493
653 18769-18800 Chemical denotes heparan sulfate polysaccharides
654 18845-18860 Chemical denotes pentasaccharide
655 19039-19046 Chemical denotes heparin MESH:D006493
668 19252-19259 Chemical denotes heparin MESH:D006493
669 19481-19488 Chemical denotes heparin MESH:D006493
670 19749-19756 Chemical denotes heparin MESH:D006493
671 19890-19897 Chemical denotes heparin MESH:D006493
672 19233-19241 Disease denotes COVID-19 MESH:C000657245
673 19297-19309 Disease denotes coagulopathy MESH:D001778
674 19396-19406 Disease denotes thrombosis MESH:D013927
675 19410-19418 Disease denotes COVID-19 MESH:C000657245
676 19561-19569 Disease denotes COVID-19 MESH:C000657245
677 19826-19838 Disease denotes coagulopathy MESH:D001778
678 19842-19858 Disease denotes critical illness MESH:D016638
679 19901-19909 Disease denotes COVID-19 MESH:C000657245
708 20112-20128 Gene denotes antithrombin-III Gene:462
709 20130-20133 Gene denotes AT3 Gene:462
710 20733-20737 Gene denotes ACE2 Gene:59272
711 20739-20770 Gene denotes angiotensin-converting enzyme 2 Gene:59272
712 20772-20775 Gene denotes APC Gene:324
713 20836-20841 Gene denotes PAI-1 Gene:5054
714 20843-20876 Gene denotes plasminogen activator inhibitor 1 Gene:5054
715 20897-20901 Gene denotes TFPI Gene:7035
716 20903-20934 Gene denotes tissue factor pathway inhibitor Gene:7035
717 20936-20939 Gene denotes TNF Gene:7124
718 20999-21002 Gene denotes uPA Gene:5328
719 20882-20895 Gene denotes tissue factor Gene:2152
720 20969-20997 Gene denotes tissue plasminogen activator Gene:100128998
721 20261-20308 Species denotes Severe acute respiratory syndrome coronavirus 2 Tax:2697049
722 20310-20320 Species denotes SARS-CoV-2 Tax:2697049
723 19984-19991 Chemical denotes heparin MESH:D006493
724 20035-20042 Chemical denotes Heparin MESH:D006493
725 20436-20451 Chemical denotes heparan sulfate MESH:D006497
726 20459-20466 Chemical denotes heparin MESH:D006493
727 20500-20507 Chemical denotes heparin MESH:D006493
728 20581-20588 Chemical denotes heparin MESH:D006493
729 20802-20817 Chemical denotes heparan sulfate MESH:D006497
730 19995-20019 Disease denotes coronavirus disease 2019 MESH:C000657245
731 20021-20029 Disease denotes COVID-19 MESH:C000657245
732 20191-20203 Disease denotes coagulopathy MESH:D001778
733 20231-20241 Disease denotes thrombosis MESH:D013927
734 20652-20660 Disease denotes COVID-19 MESH:C000657245
735 20941-20955 Disease denotes tumor necrosis MESH:D009336
738 21122-21127 Species denotes Human Tax:9606
739 21138-21157 CellLine denotes Grant F31-HL-143873 CVCL:L842

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T1 25-33 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T2 88-96 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T3 107-131 Disease denotes Coronavirus disease 2019 http://purl.obolibrary.org/obo/MONDO_0100096
T4 133-141 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T5 182-191 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T6 195-242 Disease denotes severe acute respiratory syndrome coronavirus 2 http://purl.obolibrary.org/obo/MONDO_0100096
T7 195-228 Disease denotes severe acute respiratory syndrome http://purl.obolibrary.org/obo/MONDO_0005091
T8 244-252 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T9 244-248 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T10 561-579 Disease denotes hypercoagulability http://purl.obolibrary.org/obo/MONDO_0002305
T11 597-605 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T12 872-880 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T13 872-876 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T14 883-892 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T15 1038-1046 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T16 1244-1252 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T17 1409-1417 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T18 1579-1587 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T19 1618-1627 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T20 1635-1682 Disease denotes severe acute respiratory syndrome coronavirus 2 http://purl.obolibrary.org/obo/MONDO_0100096
T21 1635-1668 Disease denotes severe acute respiratory syndrome http://purl.obolibrary.org/obo/MONDO_0005091
T22 1684-1692 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T23 1684-1688 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T24 1811-1820 Disease denotes influenza http://purl.obolibrary.org/obo/MONDO_0005812
T25 2607-2615 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T26 2729-2737 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T27 2842-2850 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T28 2842-2846 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T29 2912-2944 Disease denotes heparin-induced thrombocytopenia http://purl.obolibrary.org/obo/MONDO_0018048
T30 2928-2944 Disease denotes thrombocytopenia http://purl.obolibrary.org/obo/MONDO_0002049
T31 2946-2949 Disease denotes HIT http://purl.obolibrary.org/obo/MONDO_0018048
T32 4272-4274 Disease denotes NS http://purl.obolibrary.org/obo/MONDO_0009735
T33 4919-4927 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T34 4947-4955 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T35 4989-5001 Disease denotes coagulopathy http://purl.obolibrary.org/obo/MONDO_0001531
T36 5015-5027 Disease denotes coagulopathy http://purl.obolibrary.org/obo/MONDO_0001531
T37 5044-5052 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T38 5073-5089 Disease denotes thrombocytopenia http://purl.obolibrary.org/obo/MONDO_0002049
T39 5236-5260 Disease denotes consumptive coagulopathy http://purl.obolibrary.org/obo/MONDO_0001243
T40 5248-5260 Disease denotes coagulopathy http://purl.obolibrary.org/obo/MONDO_0001531
T41 5339-5347 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T42 5378-5384 Disease denotes injury http://purl.obolibrary.org/obo/MONDO_0021178
T43 5443-5456 Disease denotes Endotheliitis http://purl.obolibrary.org/obo/MONDO_0015292
T44 5478-5486 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T45 5478-5482 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T46 5656-5662 Disease denotes injury http://purl.obolibrary.org/obo/MONDO_0021178
T47 5707-5715 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T48 5784-5794 Disease denotes thrombosis http://purl.obolibrary.org/obo/MONDO_0000831
T49 5824-5846 Disease denotes venous thromboembolism http://purl.obolibrary.org/obo/MONDO_0005399
T50 5848-5851 Disease denotes VTE http://purl.obolibrary.org/obo/MONDO_0005399
T51 5948-5951 Disease denotes VTE http://purl.obolibrary.org/obo/MONDO_0005399
T52 5955-5963 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T53 6098-6112 Disease denotes H1N1 influenza http://purl.obolibrary.org/obo/MONDO_0005460
T54 6103-6112 Disease denotes influenza http://purl.obolibrary.org/obo/MONDO_0005812
T55 6171-6178 Disease denotes strokes http://purl.obolibrary.org/obo/MONDO_0005098|http://purl.obolibrary.org/obo/MONDO_0011057
T57 6242-6250 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T58 6242-6246 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T59 6266-6284 Disease denotes hypercoagulability http://purl.obolibrary.org/obo/MONDO_0002305
T60 6352-6360 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T61 6367-6377 Disease denotes thrombosis http://purl.obolibrary.org/obo/MONDO_0000831
T62 6487-6495 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T63 6507-6519 Disease denotes coagulopathy http://purl.obolibrary.org/obo/MONDO_0001531
T64 6524-6534 Disease denotes thromboses http://purl.obolibrary.org/obo/MONDO_0000831
T65 6646-6654 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T66 6712-6724 Disease denotes coagulopathy http://purl.obolibrary.org/obo/MONDO_0001531
T67 6826-6838 Disease denotes coagulopathy http://purl.obolibrary.org/obo/MONDO_0001531
T68 7023-7031 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T69 7099-7111 Disease denotes coagulopathy http://purl.obolibrary.org/obo/MONDO_0001531
T70 7302-7314 Disease denotes coagulopathy http://purl.obolibrary.org/obo/MONDO_0001531
T71 7343-7355 Disease denotes coagulopathy http://purl.obolibrary.org/obo/MONDO_0001531
T72 7641-7653 Disease denotes Coagulopathy http://purl.obolibrary.org/obo/MONDO_0001531
T73 7678-7702 Disease denotes coronavirus disease 2019 http://purl.obolibrary.org/obo/MONDO_0100096
T74 7704-7712 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T75 7758-7770 Disease denotes coagulopathy http://purl.obolibrary.org/obo/MONDO_0001531
T76 7845-7853 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T77 8108-8116 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T78 8217-8229 Disease denotes coagulopathy http://purl.obolibrary.org/obo/MONDO_0001531
T79 8248-8251 Disease denotes VTE http://purl.obolibrary.org/obo/MONDO_0005399
T80 8255-8263 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T81 8375-8383 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T82 8449-8457 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T83 8564-8567 Disease denotes VTE http://purl.obolibrary.org/obo/MONDO_0005399
T84 8863-8875 Disease denotes coagulopathy http://purl.obolibrary.org/obo/MONDO_0001531
T85 9110-9118 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T86 9127-9162 Disease denotes acute respiratory distress syndrome http://purl.obolibrary.org/obo/MONDO_0006502
T87 9133-9162 Disease denotes respiratory distress syndrome http://purl.obolibrary.org/obo/MONDO_0009971
T88 9197-9207 Disease denotes thrombosis http://purl.obolibrary.org/obo/MONDO_0000831
T89 9402-9410 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T90 9506-9514 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T91 10428-10436 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T92 10571-10579 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T93 10947-10955 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T94 10996-11004 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T95 10996-11000 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T96 11127-11135 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T97 11153-11161 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T98 11153-11157 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T99 11266-11274 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T100 11266-11270 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T101 11398-11406 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T102 11398-11402 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T103 11409-11418 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T104 11575-11583 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T105 11575-11579 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T106 11804-11812 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T107 11804-11808 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T108 11980-11988 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T109 11980-11984 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T110 12095-12103 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T111 12095-12099 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T112 12196-12204 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T113 12196-12200 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T114 12271-12279 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T115 12271-12275 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T116 12452-12460 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T117 12452-12456 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T118 12562-12570 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T119 12562-12566 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T120 13282-13291 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T121 13757-13768 Disease denotes hepatitis C http://purl.obolibrary.org/obo/MONDO_0005231
T122 13757-13766 Disease denotes hepatitis http://purl.obolibrary.org/obo/MONDO_0002251
T123 13892-13900 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T124 14105-14113 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T125 14240-14248 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T126 14260-14272 Disease denotes inflammation http://purl.obolibrary.org/obo/MONDO_0021166
T127 14348-14360 Disease denotes inflammation http://purl.obolibrary.org/obo/MONDO_0021166
T128 14718-14730 Disease denotes inflammation http://purl.obolibrary.org/obo/MONDO_0021166
T129 14941-14953 Disease denotes inflammation http://purl.obolibrary.org/obo/MONDO_0021166
T130 15138-15146 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T131 15138-15142 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T132 15178-15211 Disease denotes severe acute respiratory syndrome http://purl.obolibrary.org/obo/MONDO_0005091
T133 15213-15217 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T134 15340-15345 Disease denotes tumor http://purl.obolibrary.org/obo/MONDO_0005070
T135 15737-15753 Disease denotes viral infections http://purl.obolibrary.org/obo/MONDO_0005108
T136 15862-15870 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T137 16101-16113 Disease denotes inflammation http://purl.obolibrary.org/obo/MONDO_0021166
T138 16166-16178 Disease denotes inflammation http://purl.obolibrary.org/obo/MONDO_0021166
T139 16189-16201 Disease denotes pancreatitis http://purl.obolibrary.org/obo/MONDO_0004982
T140 16351-16377 Disease denotes inflammatory bowel disease http://purl.obolibrary.org/obo/MONDO_0005265
T141 16379-16385 Disease denotes asthma http://purl.obolibrary.org/obo/MONDO_0004979
T142 16417-16440 Disease denotes acute coronary syndrome http://purl.obolibrary.org/obo/MONDO_0005542
T143 16872-16878 Disease denotes trauma http://purl.obolibrary.org/obo/MONDO_0021178
T144 17080-17088 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T145 17148-17151 Disease denotes HIT http://purl.obolibrary.org/obo/MONDO_0018048
T146 17373-17389 Disease denotes thrombocytopenia http://purl.obolibrary.org/obo/MONDO_0002049
T147 17421-17431 Disease denotes thrombosis http://purl.obolibrary.org/obo/MONDO_0000831
T148 17602-17610 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T149 17663-17673 Disease denotes thrombosis http://purl.obolibrary.org/obo/MONDO_0000831
T150 17730-17736 Disease denotes injury http://purl.obolibrary.org/obo/MONDO_0021178
T151 17897-17912 Disease denotes viral pneumonia http://purl.obolibrary.org/obo/MONDO_0006012
T152 17903-17912 Disease denotes pneumonia http://purl.obolibrary.org/obo/MONDO_0005249
T153 18008-18027 Disease denotes influenza infection http://purl.obolibrary.org/obo/MONDO_0005812
T154 18018-18027 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T155 18108-18117 Disease denotes influenza http://purl.obolibrary.org/obo/MONDO_0005812
T156 18126-18132 Disease denotes injury http://purl.obolibrary.org/obo/MONDO_0021178
T157 18297-18306 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T158 18504-18513 Disease denotes pneumonia http://purl.obolibrary.org/obo/MONDO_0005249
T159 19233-19241 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T160 19297-19309 Disease denotes coagulopathy http://purl.obolibrary.org/obo/MONDO_0001531
T161 19396-19406 Disease denotes thrombosis http://purl.obolibrary.org/obo/MONDO_0000831
T162 19410-19418 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T163 19561-19569 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T164 19826-19838 Disease denotes coagulopathy http://purl.obolibrary.org/obo/MONDO_0001531
T165 19901-19909 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T166 19995-20019 Disease denotes coronavirus disease 2019 http://purl.obolibrary.org/obo/MONDO_0100096
T167 20021-20029 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T168 20191-20203 Disease denotes coagulopathy http://purl.obolibrary.org/obo/MONDO_0001531
T169 20231-20241 Disease denotes thrombosis http://purl.obolibrary.org/obo/MONDO_0000831
T170 20261-20308 Disease denotes Severe acute respiratory syndrome coronavirus 2 http://purl.obolibrary.org/obo/MONDO_0100096
T171 20310-20318 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T172 20310-20314 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T173 20652-20660 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T174 20941-20946 Disease denotes tumor http://purl.obolibrary.org/obo/MONDO_0005070
T175 20999-21002 Disease denotes uPA http://purl.obolibrary.org/obo/MONDO_0004041

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T1 11-12 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T2 257-260 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T3 330-335 http://purl.obolibrary.org/obo/CLO_0009985 denotes focus
T4 374-375 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T5 606-609 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T6 1231-1232 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T7 2633-2634 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T8 2995-2996 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T9 3117-3127 http://purl.obolibrary.org/obo/UBERON_0000160 denotes intestines
T10 3117-3127 http://www.ebi.ac.uk/efo/EFO_0000834 denotes intestines
T11 3522-3530 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T12 3551-3559 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T13 3592-3593 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T14 3802-3805 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T15 4011-4012 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T16 4455-4457 http://purl.obolibrary.org/obo/CLO_0050507 denotes 22
T17 4843-4851 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T18 4964-4965 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T19 5113-5124 http://purl.obolibrary.org/obo/PR_000007299 denotes prothrombin
T20 5234-5235 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T21 5777-5783 http://purl.obolibrary.org/obo/UBERON_0000055 denotes vessel
T22 5880-5883 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T23 6018-6020 http://purl.obolibrary.org/obo/CLO_0050510 denotes 18
T24 6022-6024 http://purl.obolibrary.org/obo/CLO_0050507 denotes 22
T25 6120-6122 http://purl.obolibrary.org/obo/CLO_0001313 denotes 36
T26 6164-6170 http://purl.obolibrary.org/obo/UBERON_0000055 denotes vessel
T27 6305-6306 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T28 6448-6450 http://purl.obolibrary.org/obo/CLO_0053799 denotes 45
T29 6839-6842 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T30 6869-6870 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T31 6886-6891 http://purl.obolibrary.org/obo/UBERON_0003103 denotes organ
T32 6911-6912 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T33 7199-7208 http://purl.obolibrary.org/obo/CLO_0001658 denotes activated
T34 7370-7371 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T35 7409-7410 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T36 7558-7562 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T37 7558-7562 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T38 7746-7747 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T39 8405-8406 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T40 8545-8546 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T41 8569-8571 http://purl.obolibrary.org/obo/CLO_0001382 denotes 48
T42 8978-8981 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T43 9025-9036 http://purl.obolibrary.org/obo/PR_000012867 denotes plasminogen
T44 9037-9046 http://purl.obolibrary.org/obo/CLO_0001658 denotes activator
T45 9048-9049 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T46 9227-9229 http://purl.obolibrary.org/obo/CLO_0053794 denotes 41
T47 9267-9270 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T48 10079-10080 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T49 10343-10345 http://purl.obolibrary.org/obo/CLO_0001000 denotes 35
T50 10402-10404 http://purl.obolibrary.org/obo/CLO_0050509 denotes 27
T51 10486-10487 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T52 10714-10715 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T53 10725-10727 http://purl.obolibrary.org/obo/CLO_0050510 denotes 18
T54 10994-10995 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T55 11174-11182 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T56 11187-11188 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T57 11220-11227 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T58 11342-11346 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T59 11636-11640 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T60 11772-11777 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T61 12020-12023 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T62 12166-12167 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T63 12309-12318 http://www.ebi.ac.uk/efo/EFO_0000876 denotes extremely
T64 12603-12604 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T65 12927-12935 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T66 13117-13125 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T67 13342-13350 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T68 13548-13551 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T69 13646-13647 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T70 13708-13713 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T71 13769-13774 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T72 13812-13813 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T73 14200-14206 http://purl.obolibrary.org/obo/UBERON_0001005 denotes airway
T74 14309-14317 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T75 14371-14375 http://purl.obolibrary.org/obo/CLO_0053704 denotes IL-8
T76 14465-14475 http://purl.obolibrary.org/obo/PR_000001318 denotes L-selectin
T77 14838-14843 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T78 14847-14848 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T79 15068-15069 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T80 15075-15076 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T81 15085-15088 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T82 15152-15157 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T83 15390-15394 http://purl.obolibrary.org/obo/CLO_0053704 denotes IL-8
T84 15413-15416 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T85 15454-15455 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T86 15456-15465 http://purl.obolibrary.org/obo/SO_0000418 denotes signaling
T87 15484-15489 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T88 15490-15507 http://purl.obolibrary.org/obo/CL_0000115 denotes endothelial cells
T89 15512-15517 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T90 15518-15527 http://purl.obolibrary.org/obo/CL_0000576 denotes monocytes
T91 15545-15546 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T92 15575-15578 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T93 15658-15659 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T94 15707-15708 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T95 15789-15793 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T96 15808-15809 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T97 15826-15829 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T98 15924-15941 http://purl.obolibrary.org/obo/CL_0000115 denotes endothelial cells
T99 15987-16000 http://purl.obolibrary.org/obo/UBERON_0002405 denotes immune system
T100 16037-16047 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T101 16076-16079 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T102 16285-16288 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T103 16326-16331 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T104 16396-16403 http://purl.obolibrary.org/obo/UBERON_0001005 denotes airways
T105 16491-16494 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T106 16554-16555 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T107 16691-16692 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T108 16738-16742 http://purl.obolibrary.org/obo/CLO_0001550 denotes a 10
T109 16777-16779 http://purl.obolibrary.org/obo/CLO_0053733 denotes 11
T110 16781-16783 http://purl.obolibrary.org/obo/CLO_0050509 denotes 27
T111 16964-16969 http://www.ebi.ac.uk/efo/EFO_0000296 denotes blood
T112 16970-16974 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T113 16996-16998 http://purl.obolibrary.org/obo/CLO_0053733 denotes 11
T114 17000-17002 http://purl.obolibrary.org/obo/CLO_0050509 denotes 27
T115 17090-17091 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T116 17527-17531 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T117 17527-17531 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T118 17674-17677 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T119 17708-17714 http://purl.obolibrary.org/obo/NCBITaxon_33208 denotes animal
T120 17725-17729 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T121 17725-17729 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T122 17784-17791 http://purl.obolibrary.org/obo/UBERON_0001005 denotes airways
T123 17792-17795 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T124 17823-17827 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T125 17823-17827 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T126 17843-17845 http://purl.obolibrary.org/obo/CLO_0001302 denotes 34
T127 17880-17886 http://purl.obolibrary.org/obo/NCBITaxon_33208 denotes animal
T128 17942-17959 http://purl.obolibrary.org/obo/UBERON_0000483 denotes epithelial tissue
T129 17985-17991 http://purl.obolibrary.org/obo/NCBITaxon_33208 denotes animal
T130 18201-18202 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T131 18691-18692 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T132 18749-18759 http://purl.obolibrary.org/obo/UBERON_0000160 denotes intestinal
T133 18749-18759 http://www.ebi.ac.uk/efo/EFO_0000834 denotes intestinal
T134 18760-18767 http://purl.obolibrary.org/obo/UBERON_0000344 denotes mucosae
T135 18843-18844 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T136 18888-18898 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T137 18944-18945 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T138 19108-19113 http://purl.obolibrary.org/obo/UBERON_0003103 denotes organ
T139 19138-19143 http://purl.obolibrary.org/obo/UBERON_0003103 denotes organ
T140 19192-19193 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T141 19419-19422 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T142 20354-20364 http://purl.obolibrary.org/obo/CL_0000066 denotes epithelial
T143 20365-20370 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T144 20423-20427 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T145 20589-20592 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T146 20777-20786 http://purl.obolibrary.org/obo/CLO_0001658 denotes activated
T147 20843-20854 http://purl.obolibrary.org/obo/PR_000012867 denotes plasminogen
T148 20855-20864 http://purl.obolibrary.org/obo/CLO_0001658 denotes activator
T149 20964-20967 http://purl.obolibrary.org/obo/CLO_0053275 denotes tPA
T150 20964-20967 http://purl.obolibrary.org/obo/CLO_0053276 denotes tPA
T151 20964-20967 http://purl.obolibrary.org/obo/CLO_0053277 denotes tPA
T152 20976-20987 http://purl.obolibrary.org/obo/PR_000012867 denotes plasminogen
T153 20988-20997 http://purl.obolibrary.org/obo/CLO_0001658 denotes activator
T154 21014-21025 http://purl.obolibrary.org/obo/PR_000012867 denotes plasminogen
T155 21026-21035 http://purl.obolibrary.org/obo/CLO_0001658 denotes activator
T156 21122-21127 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes Human
T157 21313-21314 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T158 21437-21438 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T159 21507-21508 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T160 21572-21573 http://purl.obolibrary.org/obo/CLO_0001020 denotes A

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T1 0-7 Chemical denotes Heparin http://purl.obolibrary.org/obo/CHEBI_28304
T2 690-697 Chemical denotes heparin http://purl.obolibrary.org/obo/CHEBI_28304
T3 776-783 Chemical denotes heparin http://purl.obolibrary.org/obo/CHEBI_28304
T4 837-850 Chemical denotes anticoagulant http://purl.obolibrary.org/obo/CHEBI_50249
T5 980-987 Chemical denotes heparin http://purl.obolibrary.org/obo/CHEBI_28304
T6 1002-1009 Chemical denotes heparin http://purl.obolibrary.org/obo/CHEBI_28304
T7 1015-1020 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T8 1055-1064 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T9 1220-1227 Chemical denotes heparin http://purl.obolibrary.org/obo/CHEBI_28304
T10 1345-1359 Chemical denotes anticoagulants http://purl.obolibrary.org/obo/CHEBI_50249
T11 1397-1404 Chemical denotes heparin http://purl.obolibrary.org/obo/CHEBI_28304
T12 2235-2242 Chemical denotes heparin http://purl.obolibrary.org/obo/CHEBI_28304
T13 2268-2276 Chemical denotes heparins http://purl.obolibrary.org/obo/CHEBI_24505
T14 2311-2318 Chemical denotes heparin http://purl.obolibrary.org/obo/CHEBI_28304
T15 2524-2531 Chemical denotes heparin http://purl.obolibrary.org/obo/CHEBI_28304
T16 2590-2603 Chemical denotes anticoagulant http://purl.obolibrary.org/obo/CHEBI_50249
T17 2649-2662 Chemical denotes anticoagulant http://purl.obolibrary.org/obo/CHEBI_50249
T18 2674-2681 Chemical denotes heparin http://purl.obolibrary.org/obo/CHEBI_28304
T19 2813-2820 Chemical denotes heparin http://purl.obolibrary.org/obo/CHEBI_28304
T20 2912-2919 Chemical denotes heparin http://purl.obolibrary.org/obo/CHEBI_28304
T21 2984-2991 Chemical denotes Heparin http://purl.obolibrary.org/obo/CHEBI_28304
T22 3055-3070 Chemical denotes heparan sulfate http://purl.obolibrary.org/obo/CHEBI_28815
T23 3055-3062 Chemical denotes heparan http://purl.obolibrary.org/obo/CHEBI_24500
T24 3063-3070 Chemical denotes sulfate http://purl.obolibrary.org/obo/CHEBI_16189
T25 3072-3074 Chemical denotes HS http://purl.obolibrary.org/obo/CHEBI_74056|http://purl.obolibrary.org/obo/CHEBI_28815
T27 3076-3094 Chemical denotes glycosaminoglycans http://purl.obolibrary.org/obo/CHEBI_18085
T28 3181-3183 Chemical denotes HS http://purl.obolibrary.org/obo/CHEBI_74056|http://purl.obolibrary.org/obo/CHEBI_28815
T30 3184-3201 Chemical denotes glycosaminoglycan http://purl.obolibrary.org/obo/CHEBI_18085
T31 3217-3224 Chemical denotes heparin http://purl.obolibrary.org/obo/CHEBI_28304
T32 3316-3323 Chemical denotes heparin http://purl.obolibrary.org/obo/CHEBI_28304
T33 3387-3395 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T34 3441-3466 Chemical denotes serine protease inhibitor http://purl.obolibrary.org/obo/CHEBI_64926
T35 3441-3447 Chemical denotes serine http://purl.obolibrary.org/obo/CHEBI_17822
T36 3448-3466 Chemical denotes protease inhibitor http://purl.obolibrary.org/obo/CHEBI_37670|http://purl.obolibrary.org/obo/CHEBI_60258
T38 3457-3466 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T39 3508-3521 Chemical denotes anticoagulant http://purl.obolibrary.org/obo/CHEBI_50249
T40 3537-3550 Chemical denotes anticoagulant http://purl.obolibrary.org/obo/CHEBI_50249
T41 3602-3617 Chemical denotes pentasaccharide http://purl.obolibrary.org/obo/CHEBI_35369
T42 3641-3643 Chemical denotes HS http://purl.obolibrary.org/obo/CHEBI_74056|http://purl.obolibrary.org/obo/CHEBI_28815
T44 3746-3753 Chemical denotes heparin http://purl.obolibrary.org/obo/CHEBI_28304
T45 3754-3761 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T46 3914-3921 Chemical denotes heparin http://purl.obolibrary.org/obo/CHEBI_28304
T47 3989-3996 Chemical denotes heparin http://purl.obolibrary.org/obo/CHEBI_28304
T48 4034-4049 Chemical denotes heparan sulfate http://purl.obolibrary.org/obo/CHEBI_28815
T49 4034-4041 Chemical denotes heparan http://purl.obolibrary.org/obo/CHEBI_24500
T50 4042-4049 Chemical denotes sulfate http://purl.obolibrary.org/obo/CHEBI_16189
T51 4051-4053 Chemical denotes HS http://purl.obolibrary.org/obo/CHEBI_74056|http://purl.obolibrary.org/obo/CHEBI_28815
T53 4055-4073 Chemical denotes glycosaminoglycans http://purl.obolibrary.org/obo/CHEBI_18085
T54 4080-4082 Chemical denotes HS http://purl.obolibrary.org/obo/CHEBI_74056|http://purl.obolibrary.org/obo/CHEBI_28815
T56 4115-4127 Chemical denotes disaccharide http://purl.obolibrary.org/obo/CHEBI_36233
T57 4137-4156 Chemical denotes N-acetylglucosamine http://purl.obolibrary.org/obo/CHEBI_28009|http://purl.obolibrary.org/obo/CHEBI_59640
T59 4158-4164 Chemical denotes GlcNAc http://purl.obolibrary.org/obo/CHEBI_506227|http://purl.obolibrary.org/obo/CHEBI_73685
T61 4170-4185 Chemical denotes glucuronic acid http://purl.obolibrary.org/obo/CHEBI_24298
T62 4181-4185 Chemical denotes acid http://purl.obolibrary.org/obo/CHEBI_37527
T63 4187-4191 Chemical denotes GlcA http://purl.obolibrary.org/obo/CHEBI_24298
T64 4196-4209 Chemical denotes iduronic acid http://purl.obolibrary.org/obo/CHEBI_24769
T65 4205-4209 Chemical denotes acid http://purl.obolibrary.org/obo/CHEBI_37527
T66 4211-4215 Chemical denotes IdoA http://purl.obolibrary.org/obo/CHEBI_24769
T67 4218-4224 Chemical denotes GlcNAc http://purl.obolibrary.org/obo/CHEBI_506227|http://purl.obolibrary.org/obo/CHEBI_73685
T69 4272-4274 Chemical denotes NS http://purl.obolibrary.org/obo/CHEBI_73426
T70 4289-4293 Chemical denotes IdoA http://purl.obolibrary.org/obo/CHEBI_24769
T71 4323-4330 Chemical denotes heparin http://purl.obolibrary.org/obo/CHEBI_28304
T72 4346-4348 Chemical denotes HS http://purl.obolibrary.org/obo/CHEBI_74056|http://purl.obolibrary.org/obo/CHEBI_28815
T74 4369-4380 Chemical denotes saccharides http://purl.obolibrary.org/obo/CHEBI_16646
T75 4421-4428 Chemical denotes heparin http://purl.obolibrary.org/obo/CHEBI_28304
T76 4441-4443 Chemical denotes HS http://purl.obolibrary.org/obo/CHEBI_74056|http://purl.obolibrary.org/obo/CHEBI_28815
T78 4458-4469 Chemical denotes saccharides http://purl.obolibrary.org/obo/CHEBI_16646
T79 4510-4517 Chemical denotes heparin http://purl.obolibrary.org/obo/CHEBI_28304
T80 4558-4573 Chemical denotes pentasaccharide http://purl.obolibrary.org/obo/CHEBI_35369
T81 4615-4622 Chemical denotes heparin http://purl.obolibrary.org/obo/CHEBI_28304
T82 4626-4651 Chemical denotes serine protease inhibitor http://purl.obolibrary.org/obo/CHEBI_64926
T83 4626-4632 Chemical denotes serine http://purl.obolibrary.org/obo/CHEBI_17822
T84 4633-4651 Chemical denotes protease inhibitor http://purl.obolibrary.org/obo/CHEBI_37670|http://purl.obolibrary.org/obo/CHEBI_60258
T86 4642-4651 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T87 4699-4712 Chemical denotes anticoagulant http://purl.obolibrary.org/obo/CHEBI_50249
T88 4772-4779 Chemical denotes heparin http://purl.obolibrary.org/obo/CHEBI_28304
T89 4877-4885 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T90 5131-5133 Chemical denotes PT http://purl.obolibrary.org/obo/CHEBI_141395
T91 7172-7189 Chemical denotes pathway inhibitor http://purl.obolibrary.org/obo/CHEBI_76932
T92 7180-7189 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T93 7209-7216 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T94 7609-7622 Chemical denotes anticoagulant http://purl.obolibrary.org/obo/CHEBI_50249
T95 8138-8152 Chemical denotes anticoagulants http://purl.obolibrary.org/obo/CHEBI_50249
T96 8291-8298 Chemical denotes heparin http://purl.obolibrary.org/obo/CHEBI_28304
T97 8344-8351 Chemical denotes heparin http://purl.obolibrary.org/obo/CHEBI_28304
T98 8358-8371 Chemical denotes anticoagulant http://purl.obolibrary.org/obo/CHEBI_50249
T99 8615-8622 Chemical denotes heparin http://purl.obolibrary.org/obo/CHEBI_28304
T100 8745-8752 Chemical denotes heparin http://purl.obolibrary.org/obo/CHEBI_28304
T101 8910-8917 Chemical denotes heparin http://purl.obolibrary.org/obo/CHEBI_28304
T102 9391-9398 Chemical denotes heparin http://purl.obolibrary.org/obo/CHEBI_28304
T103 10159-10166 Chemical denotes heparin http://purl.obolibrary.org/obo/CHEBI_28304
T104 10298-10300 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T106 10356-10361 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T107 10390-10397 Chemical denotes heparin http://purl.obolibrary.org/obo/CHEBI_28304
T108 10496-10501 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T109 10628-10635 Chemical denotes heparin http://purl.obolibrary.org/obo/CHEBI_28304
T110 11102-11109 Chemical denotes heparin http://purl.obolibrary.org/obo/CHEBI_28304
T111 11164-11173 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T112 11450-11457 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T113 11466-11477 Chemical denotes angiotensin http://purl.obolibrary.org/obo/CHEBI_48433
T114 11649-11664 Chemical denotes heparan sulfate http://purl.obolibrary.org/obo/CHEBI_28815
T115 11649-11656 Chemical denotes heparan http://purl.obolibrary.org/obo/CHEBI_24500
T116 11657-11664 Chemical denotes sulfate http://purl.obolibrary.org/obo/CHEBI_16189
T117 11679-11697 Chemical denotes glycosaminoglycans http://purl.obolibrary.org/obo/CHEBI_18085
T118 11707-11714 Chemical denotes heparin http://purl.obolibrary.org/obo/CHEBI_28304
T119 11819-11834 Chemical denotes Heparan sulfate http://purl.obolibrary.org/obo/CHEBI_28815
T120 11827-11834 Chemical denotes sulfate http://purl.obolibrary.org/obo/CHEBI_16189
T121 11873-11880 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T122 11896-11904 Chemical denotes molecule http://purl.obolibrary.org/obo/CHEBI_25367
T123 12112-12119 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T124 12140-12155 Chemical denotes heparan sulfate http://purl.obolibrary.org/obo/CHEBI_28815
T125 12140-12147 Chemical denotes heparan http://purl.obolibrary.org/obo/CHEBI_24500
T126 12148-12155 Chemical denotes sulfate http://purl.obolibrary.org/obo/CHEBI_16189
T127 12223-12231 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T128 12288-12295 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T129 12363-12370 Chemical denotes heparin http://purl.obolibrary.org/obo/CHEBI_28304
T130 12501-12508 Chemical denotes heparin http://purl.obolibrary.org/obo/CHEBI_28304
T131 12515-12524 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T132 12541-12548 Chemical denotes heparin http://purl.obolibrary.org/obo/CHEBI_28304
T133 12579-12586 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T134 12617-12626 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T135 12703-12711 Chemical denotes heparins http://purl.obolibrary.org/obo/CHEBI_24505
T136 12775-12782 Chemical denotes heparin http://purl.obolibrary.org/obo/CHEBI_28304
T137 12819-12826 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T138 12917-12926 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T139 12962-12969 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T140 13036-13043 Chemical denotes heparin http://purl.obolibrary.org/obo/CHEBI_28304
T141 13107-13116 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T142 13157-13170 Chemical denotes anticoagulant http://purl.obolibrary.org/obo/CHEBI_50249
T143 13218-13225 Chemical denotes heparin http://purl.obolibrary.org/obo/CHEBI_28304
T144 13332-13341 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T145 13414-13421 Chemical denotes heparin http://purl.obolibrary.org/obo/CHEBI_28304
T146 13444-13453 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T147 13490-13497 Chemical denotes heparin http://purl.obolibrary.org/obo/CHEBI_28304
T148 13508-13526 Chemical denotes glycosaminoglycans http://purl.obolibrary.org/obo/CHEBI_18085
T149 13530-13539 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T150 13627-13642 Chemical denotes heparan sulfate http://purl.obolibrary.org/obo/CHEBI_28815
T151 13627-13634 Chemical denotes heparan http://purl.obolibrary.org/obo/CHEBI_24500
T152 13635-13642 Chemical denotes sulfate http://purl.obolibrary.org/obo/CHEBI_16189
T153 13648-13656 Chemical denotes cofactor http://purl.obolibrary.org/obo/CHEBI_23357
T154 13925-13934 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T155 13950-13957 Chemical denotes heparin http://purl.obolibrary.org/obo/CHEBI_28304
T156 13962-13969 Chemical denotes heparin http://purl.obolibrary.org/obo/CHEBI_28304
T157 13975-13980 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T158 14114-14121 Chemical denotes Heparin http://purl.obolibrary.org/obo/CHEBI_28304
T159 14274-14281 Chemical denotes Heparin http://purl.obolibrary.org/obo/CHEBI_28304
T160 14326-14334 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T161 14371-14373 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T163 14501-14508 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T164 14540-14547 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T165 14596-14603 Chemical denotes heparin http://purl.obolibrary.org/obo/CHEBI_28304
T166 14624-14639 Chemical denotes heparan sulfate http://purl.obolibrary.org/obo/CHEBI_28815
T167 14624-14631 Chemical denotes heparan http://purl.obolibrary.org/obo/CHEBI_24500
T168 14632-14639 Chemical denotes sulfate http://purl.obolibrary.org/obo/CHEBI_16189
T169 14640-14657 Chemical denotes glycosaminoglycan http://purl.obolibrary.org/obo/CHEBI_18085
T170 14772-14780 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T171 14922-14929 Chemical denotes heparin http://purl.obolibrary.org/obo/CHEBI_28304
T172 15071-15073 Chemical denotes NF http://purl.obolibrary.org/obo/CHEBI_141424|http://purl.obolibrary.org/obo/CHEBI_25573|http://purl.obolibrary.org/obo/CHEBI_1224
T175 15321-15329 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T176 15373-15375 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T178 15380-15382 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T180 15390-15392 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T182 15405-15412 Chemical denotes Heparin http://purl.obolibrary.org/obo/CHEBI_28304
T183 15450-15452 Chemical denotes NF http://purl.obolibrary.org/obo/CHEBI_141424|http://purl.obolibrary.org/obo/CHEBI_25573|http://purl.obolibrary.org/obo/CHEBI_1224
T186 15469-15472 Chemical denotes LPS http://purl.obolibrary.org/obo/CHEBI_16412|http://purl.obolibrary.org/obo/CHEBI_52603|http://purl.obolibrary.org/obo/CHEBI_89981
T189 15557-15564 Chemical denotes heparin http://purl.obolibrary.org/obo/CHEBI_28304
T190 15570-15574 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T191 15634-15639 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T192 15880-15887 Chemical denotes heparin http://purl.obolibrary.org/obo/CHEBI_28304
T193 16068-16075 Chemical denotes heparin http://purl.obolibrary.org/obo/CHEBI_28304
T194 16247-16254 Chemical denotes heparin http://purl.obolibrary.org/obo/CHEBI_28304
T195 16261-16284 Chemical denotes anti-inflammatory agent http://purl.obolibrary.org/obo/CHEBI_67079
T196 16483-16490 Chemical denotes heparin http://purl.obolibrary.org/obo/CHEBI_28304
T197 16680-16687 Chemical denotes heparin http://purl.obolibrary.org/obo/CHEBI_28304
T198 16705-16718 Chemical denotes anticoagulant http://purl.obolibrary.org/obo/CHEBI_50249
T199 17129-17136 Chemical denotes heparin http://purl.obolibrary.org/obo/CHEBI_28304
T200 17215-17222 Chemical denotes heparin http://purl.obolibrary.org/obo/CHEBI_28304
T201 17314-17321 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T202 17481-17488 Chemical denotes heparin http://purl.obolibrary.org/obo/CHEBI_28304
T203 18421-18435 Chemical denotes anticoagulants http://purl.obolibrary.org/obo/CHEBI_50249
T204 18455-18462 Chemical denotes heparin http://purl.obolibrary.org/obo/CHEBI_28304
T205 18524-18531 Chemical denotes heparin http://purl.obolibrary.org/obo/CHEBI_28304
T206 18668-18675 Chemical denotes heparin http://purl.obolibrary.org/obo/CHEBI_28304
T207 18693-18700 Chemical denotes mixture http://purl.obolibrary.org/obo/CHEBI_60004
T208 18769-18784 Chemical denotes heparan sulfate http://purl.obolibrary.org/obo/CHEBI_28815
T209 18769-18776 Chemical denotes heparan http://purl.obolibrary.org/obo/CHEBI_24500
T210 18777-18784 Chemical denotes sulfate http://purl.obolibrary.org/obo/CHEBI_16189
T211 18785-18800 Chemical denotes polysaccharides http://purl.obolibrary.org/obo/CHEBI_18154
T212 18845-18860 Chemical denotes pentasaccharide http://purl.obolibrary.org/obo/CHEBI_35369
T213 18999-19012 Chemical denotes anticoagulant http://purl.obolibrary.org/obo/CHEBI_50249
T214 19039-19046 Chemical denotes heparin http://purl.obolibrary.org/obo/CHEBI_28304
T215 19252-19259 Chemical denotes heparin http://purl.obolibrary.org/obo/CHEBI_28304
T216 19481-19488 Chemical denotes heparin http://purl.obolibrary.org/obo/CHEBI_28304
T217 19513-19526 Chemical denotes anticoagulant http://purl.obolibrary.org/obo/CHEBI_50249
T218 19584-19593 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T219 19749-19756 Chemical denotes heparin http://purl.obolibrary.org/obo/CHEBI_28304
T220 19890-19897 Chemical denotes heparin http://purl.obolibrary.org/obo/CHEBI_28304
T221 19984-19991 Chemical denotes heparin http://purl.obolibrary.org/obo/CHEBI_28304
T222 20068-20081 Chemical denotes anticoagulant http://purl.obolibrary.org/obo/CHEBI_50249
T223 20436-20451 Chemical denotes heparan sulfate http://purl.obolibrary.org/obo/CHEBI_28815
T224 20436-20443 Chemical denotes heparan http://purl.obolibrary.org/obo/CHEBI_24500
T225 20444-20451 Chemical denotes sulfate http://purl.obolibrary.org/obo/CHEBI_16189
T226 20459-20466 Chemical denotes heparin http://purl.obolibrary.org/obo/CHEBI_28304
T227 20500-20507 Chemical denotes heparin http://purl.obolibrary.org/obo/CHEBI_28304
T228 20513-20518 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T229 20581-20588 Chemical denotes heparin http://purl.obolibrary.org/obo/CHEBI_28304
T230 20739-20750 Chemical denotes angiotensin http://purl.obolibrary.org/obo/CHEBI_48433
T231 20772-20775 Chemical denotes APC http://purl.obolibrary.org/obo/CHEBI_80551
T232 20787-20794 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T233 20798-20800 Chemical denotes HS http://purl.obolibrary.org/obo/CHEBI_74056|http://purl.obolibrary.org/obo/CHEBI_28815
T235 20802-20817 Chemical denotes heparan sulfate http://purl.obolibrary.org/obo/CHEBI_28815
T236 20802-20809 Chemical denotes heparan http://purl.obolibrary.org/obo/CHEBI_24500
T237 20810-20817 Chemical denotes sulfate http://purl.obolibrary.org/obo/CHEBI_16189
T238 20819-20821 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T240 20865-20874 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T241 20878-20880 Chemical denotes TF http://purl.obolibrary.org/obo/CHEBI_74862
T242 20917-20934 Chemical denotes pathway inhibitor http://purl.obolibrary.org/obo/CHEBI_76932
T243 20925-20934 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T244 21148-21150 Chemical denotes HL http://purl.obolibrary.org/obo/CHEBI_5729

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T1 3508-3530 http://purl.obolibrary.org/obo/GO_0050819 denotes anticoagulant activity
T2 3537-3559 http://purl.obolibrary.org/obo/GO_0050819 denotes anticoagulant activity
T3 4187-4191 http://purl.obolibrary.org/obo/GO_0043879 denotes GlcA
T4 4739-4748 http://purl.obolibrary.org/obo/GO_0051923 denotes sulfation
T5 5628-5639 http://purl.obolibrary.org/obo/GO_0050817 denotes coagulation
T6 7480-7491 http://purl.obolibrary.org/obo/GO_0050817 denotes coagulation
T7 9025-9046 http://purl.obolibrary.org/obo/GO_0031639 denotes plasminogen activator
T8 10180-10191 http://purl.obolibrary.org/obo/GO_0050817 denotes coagulation
T9 11342-11353 http://purl.obolibrary.org/obo/GO_0140253 denotes cell fusion
T10 11342-11353 http://purl.obolibrary.org/obo/GO_0045026 denotes cell fusion
T11 11342-11353 http://purl.obolibrary.org/obo/GO_0000768 denotes cell fusion
T12 11342-11353 http://purl.obolibrary.org/obo/GO_0000747 denotes cell fusion
T13 14260-14272 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T14 14348-14360 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T15 14386-14392 http://purl.obolibrary.org/obo/GO_0040007 denotes growth
T16 14718-14730 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T17 14941-14953 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T18 15031-15051 http://purl.obolibrary.org/obo/GO_0000981 denotes transcription factor
T19 15031-15044 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T20 15122-15134 http://purl.obolibrary.org/obo/GO_0009405 denotes pathogenesis
T21 15305-15320 http://purl.obolibrary.org/obo/GO_0006955 denotes immune response
T22 15346-15354 http://purl.obolibrary.org/obo/GO_0070265 denotes necrosis
T23 15346-15354 http://purl.obolibrary.org/obo/GO_0019835 denotes necrosis
T24 15346-15354 http://purl.obolibrary.org/obo/GO_0008219 denotes necrosis
T25 15346-15354 http://purl.obolibrary.org/obo/GO_0001906 denotes necrosis
T26 15456-15465 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T27 15721-15733 http://purl.obolibrary.org/obo/GO_0009405 denotes pathogenesis
T28 15737-15753 http://purl.obolibrary.org/obo/GO_0016032 denotes viral infections
T29 15980-15993 http://purl.obolibrary.org/obo/GO_0045087 denotes innate immune
T30 16012-16047 http://purl.obolibrary.org/obo/GO_1902564 denotes inhibition of neutrophil activation
T31 16026-16047 http://purl.obolibrary.org/obo/GO_0042119 denotes neutrophil activation
T32 16101-16113 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T33 16166-16178 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T34 17556-17567 http://purl.obolibrary.org/obo/GO_0050817 denotes coagulation
T35 17743-17754 http://purl.obolibrary.org/obo/GO_0050817 denotes coagulation
T36 18179-18190 http://purl.obolibrary.org/obo/GO_0050817 denotes coagulation
T37 18367-18378 http://purl.obolibrary.org/obo/GO_0050817 denotes coagulation
T38 18968-18977 http://purl.obolibrary.org/obo/GO_0051923 denotes sulfation
T39 19013-19022 http://purl.obolibrary.org/obo/GO_0051923 denotes sulfation
T40 19066-19072 http://purl.obolibrary.org/obo/GO_0040007 denotes growth
T41 20843-20864 http://purl.obolibrary.org/obo/GO_0031639 denotes plasminogen activator
T42 20947-20955 http://purl.obolibrary.org/obo/GO_0070265 denotes necrosis
T43 20947-20955 http://purl.obolibrary.org/obo/GO_0019835 denotes necrosis
T44 20947-20955 http://purl.obolibrary.org/obo/GO_0008219 denotes necrosis
T45 20947-20955 http://purl.obolibrary.org/obo/GO_0001906 denotes necrosis
T46 20976-20997 http://purl.obolibrary.org/obo/GO_0031639 denotes plasminogen activator
T47 21014-21035 http://purl.obolibrary.org/obo/GO_0031639 denotes plasminogen activator

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T1 0-76 Sentence denotes Heparin as a therapy for COVID-19: current evidence and future possibilities
T2 77-96 Sentence denotes HEPARIN IN COVID-19
T3 98-106 Sentence denotes Abstract
T4 107-304 Sentence denotes Coronavirus disease 2019 (COVID-19), the clinical syndrome associated with infection by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has impacted nearly every country in the world.
T5 305-441 Sentence denotes Despite an unprecedented focus of scientific investigation, there is a paucity of evidence-based pharmacotherapies against this disease.
T6 442-551 Sentence denotes Because of this lack of data-driven treatment strategies, broad variations in practice patterns have emerged.
T7 552-698 Sentence denotes Observed hypercoagulability in patients with COVID-19 has created debate within the critical care community on the therapeutic utility of heparin.
T8 699-893 Sentence denotes We seek to provide an overview of the data supporting the therapeutic use of heparin, both unfractionated and low molecular weight, as an anticoagulant for the treatment of SARS-CoV-2 infection.
T9 894-1095 Sentence denotes Additionally, we review preclinical evidence establishing biological plausibility for heparin and synthetic heparin-like drugs as therapies for COVID-19 through antiviral and anti-inflammatory effects.
T10 1096-1315 Sentence denotes Finally, we discuss known adverse effects and theoretical off-target effects that may temper enthusiasm for the adoption of heparin as a therapy in COVID-19 without confirmatory prospective randomized controlled trials.
T11 1316-1546 Sentence denotes Despite previous failures of anticoagulants in critical illness, plausibility of heparin for COVID-19 is sufficiently robust to justify urgent randomized controlled trials to determine the safety and effectiveness of this therapy.
T12 1548-1560 Sentence denotes INTRODUCTION
T13 1561-1838 Sentence denotes Coronavirus 2019 (COVID-19), the disease associated with infection by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), was first reported in December 2019 (50) and is now the most significant worldwide public health crisis since the influenza pandemic of 1918.
T14 1839-1943 Sentence denotes Despite this immense global burden, no pharmacologic therapies have proven definitively beneficial (25).
T15 1944-2155 Sentence denotes On the basis of our clinical experience in intensive care units in Colorado and those shared by the wider critical care community, we conclude that many therapies are being administered despite limited evidence.
T16 2156-2277 Sentence denotes Anticoagulants that have been utilized widely are unfractionated (full-length) heparin and low-molecular weight heparins.
T17 2278-2419 Sentence denotes For the purposes of this review, heparin herein refers to both unfractionated and low-molecular weight variants, unless otherwise designated.
T18 2420-2616 Sentence denotes In this review, we discuss the pathophysiologic rationale and current evidence for the use of full-dose heparin (i.e., therapeutic rather than prophylactic dosing) as an anticoagulant in COVID-19.
T19 2617-2738 Sentence denotes We also discuss a subset of non-anticoagulant effects of heparin that may prove beneficial for the treatment of COVID-19.
T20 2739-2951 Sentence denotes Finally, we discuss potential risks associated with the implementation of heparin for the treatment of SARS-CoV-2, including but not limited to bleeding and immune-mediated heparin-induced thrombocytopenia (HIT).
T21 2953-2983 Sentence denotes HEPARIN STRUCTURE AND FUNCTION
T22 2984-3141 Sentence denotes Heparin is a heterogeneous preparation of long, linear highly sulfated heparan sulfate (HS) glycosaminoglycans purified from porcine intestines (see Fig. 1).
T23 3142-3296 Sentence denotes The sulfated nature of its constituent HS glycosaminoglycan chains confers heparin with the highest negative charge density of any known biomolecule (43).
T24 3297-3531 Sentence denotes This charge allows heparin to strongly and selectively interact with an immense number of proteins, the most classic being its interaction with serine protease inhibitor antithrombin-III (AT3) that provides its anticoagulant activity.
T25 3532-3698 Sentence denotes This anticoagulant activity is dependent on the presence of a precise pentasaccharide sequence within longer HS chains that allows for AT3 binding as shown in Fig. 1.
T26 3699-3953 Sentence denotes Beyond AT3, hundreds of biologically relevant, heparin-protein interactions have been described, which has led to the recognition of an immense number of potential off-target (both positive and negative) effects of heparin of unknown clinical importance.
T27 3954-3961 Sentence denotes Fig. 1.
T28 3963-3997 Sentence denotes Structure and function of heparin.
T29 3998-4074 Sentence denotes Heparins are a heterogeneous mix of heparan sulfate (HS) glycosaminoglycans.
T30 4075-4217 Sentence denotes Each HS strand is composed of repeating disaccharide units of N-acetylglucosamine (GlcNAc) and glucuronic acid (GlcA) or iduronic acid (IdoA).
T31 4218-4307 Sentence denotes GlcNAc can be sulfated at three distinct sites (-6S, -NS, and -3S) and IdoA at one (-2S).
T32 4308-4482 Sentence denotes Unfractionated heparin is composed of HS chains that are >30 saccharides in length, whereas low-molecular weight heparin constituent HS chains are 22 saccharides or less (3).
T33 4483-4720 Sentence denotes The charge distribution of heparin imparted by the presence of the precise pentasaccharide sequence shown allows for the binding of heparin to serine protease inhibitor antithrombin-III (AT3), conferring its primary anticoagulant effect.
T34 4721-4886 Sentence denotes Innumerable other sulfation sequences are found in heparin preparations, which leads to binding and biologically relevant activity modulation of many other proteins.
T35 4888-4927 Sentence denotes COAGULOPATHY AND THROMBOSIS IN COVID-19
T36 4928-5010 Sentence denotes Many patients with COVID-19 develop a clinically significant coagulopathy (7, 32).
T37 5011-5265 Sentence denotes The coagulopathy associated with COVID-19 is characterized by thrombocytopenia, minor prolongation of prothrombin time (PT) and partial thromboplastin time (aPTT), and elevated serum D-dimer and fibrinogen, consistent with a consumptive coagulopathy (7).
T38 5266-5556 Sentence denotes This profile is compatible with postmortem examinations of patients with COVID-19 describing severe endothelial injury, microangiopathy, and alveolar capillary microthrombi (2) Endotheliitis directly elicited by SARS-CoV-2 may be the pathophysiologic link to these postmortem findings (39).
T39 5557-5795 Sentence denotes In addition to laboratory and histopathological evidence of disordered coagulation and endothelial injury, several reports suggest that patients with COVID-19 are at high risk for developing clinically significant large-vessel thrombosis.
T40 5796-6146 Sentence denotes Early anecdotal evidence of venous thromboembolism (VTE) in critically ill patients has been confirmed by multiple case series describing high rates of VTE in COVID-19, with incidence estimates ranging between 8% and 54% (18, 22), significantly exceeding those reported in critically ill patients with H1N1 influenza of 2% (36) and sepsis of 5% (30).
T41 6147-6290 Sentence denotes Reports of large-vessel strokes in patients, including those younger than 50 yr, infected with SARS-CoV-2 also suggest hypercoagulability (28).
T42 6291-6452 Sentence denotes Concordantly, a postmortem study of 12 patients positive for COVID-19 found thrombosis in 58% of cases, which was found to be responsible for 25% of deaths (45).
T43 6453-6592 Sentence denotes Taken together, it is likely that COVID-19-associated coagulopathy and thromboses contribute to the morbidity and mortality of the disease.
T44 6593-6812 Sentence denotes However, it is important to recognize that other non-COVID-19 critical illnesses have demonstrated similar evidence of coagulopathy, yet failed to benefit from anticoagulation treatment in randomized controlled studies.
T45 6813-7057 Sentence denotes For example, coagulopathy has been widely recognized as a contributor to organ failure in sepsis, a disease characterized by circulating D-dimer concentrations that approximate levels observed in patients with COVID-19 (Fig. 2; 10, 32, 38, 40).
T46 7058-7315 Sentence denotes However, studies that have targeted this coagulopathy in sepsis with thrombomodulin (40), AT3 (42), tissue factor pathway inhibitor (1), and activated protein C (31) have all failed to improve mortality, despite improving laboratory indexes of coagulopathy.
T47 7316-7444 Sentence denotes These studies suggest that coagulopathy may simply be a consequence of sepsis, as opposed to a key pathogenic driver of disease.
T48 7445-7631 Sentence denotes Alternatively, as discussed below, coagulation may impart both harmful and protective effects within the injured lung, negating any clinical benefit (or harm) from anticoagulant therapy.
T49 7632-7639 Sentence denotes Fig. 2.
T50 7641-7714 Sentence denotes Coagulopathy in sepsis compared with coronavirus disease 2019 (COVID-19).
T51 7715-7854 Sentence denotes Circulating levels of D-dimer, a marker of coagulopathy, have been found to be significantly and similarly elevated in sepsis and COVID-19.
T52 7855-7909 Sentence denotes This panel represents medians and interquartile range.
T53 7910-7918 Sentence denotes Studies:
T54 7919-8006 Sentence denotes Bernard et al. (10), Vincent et al. (40), Tang et al. (38), and Richardson et al. (32).
T55 8007-8075 Sentence denotes NYC, New York City; pts, patients; RCT, randomized controlled trial.
T56 8077-8116 Sentence denotes HEPARIN AS AN ANTICOAGULANT IN COVID-19
T57 8117-8328 Sentence denotes Previous failures of anticoagulants in critical illness notwithstanding, compelling observations of coagulopathy and high rates of VTE in COVID-19 raise the possibility that heparin may benefit patient outcomes.
T58 8329-8573 Sentence denotes The utility of heparin as an anticoagulant in COVID-19 was first posited by a retrospective report of 449 patients with COVID-19 from Wuhan, China, where prophylaxis in medical patients is relatively uncommon due to a low incidence of VTE (48).
T59 8574-8753 Sentence denotes In this cohort, 350 patients received no heparin therapy (neither low-dose prophylactic nor high-dose therapeutic), whereas 99 had received low-dose prophylactic doses of heparin.
T60 8754-8974 Sentence denotes Patients with an elevated D-dimer (>6-fold higher than the upper limit of normal) or elevated sepsis-induced coagulopathy scores that received prophylactic heparin had ~20% lower mortality than patients who had not (38).
T61 8975-9231 Sentence denotes It has also been reported that intravenous tissue plasminogen activator, a potent thrombolytic, can transiently improve oxygenation in COVID-19-related acute respiratory distress syndrome, supporting clinical relevance of thrombosis in severe disease (41).
T62 9232-9411 Sentence denotes Since these initial reports, there has been one study published and two studies available in preprint format that have investigated the effects of therapeutic heparin in COVID-19.
T63 9412-9553 Sentence denotes The largest available study evaluating anticoagulation was an analysis of 2,773 patients with COVID-19 in the Mount Sinai Health System (29).
T64 9554-9772 Sentence denotes In patients requiring invasive mechanical ventilation included in this cohort, anticoagulation was associated with an in-hospital mortality of 29.1% compared with 62.7% for patients who did not receive anticoagulation.
T65 9773-9920 Sentence denotes In contrast, this study found that patients who received anticoagulation were significantly more likely to require invasive mechanical ventilation.
T66 9921-10075 Sentence denotes This report was retrospective, and the rationale for anticoagulation was not directly investigated, thus making these observations difficult to interpret.
T67 10076-10347 Sentence denotes In a smaller retrospective cohort study evaluating 44 patients, those who received heparin had improved coagulation parameters and normalized immunity as evidenced by increased lymphocyte counts and decreased interleukin (IL)-6 levels compared with control subjects (35).
T68 10348-10507 Sentence denotes Another group observed that initiation of heparin for 27 patients infected with COVID-19 improved oxygenation; this study did not include a control group (26).
T69 10508-10687 Sentence denotes Based on these limited data, clinical treatment guidelines for COVID-19 have not yet recommended the use of therapeutic heparin or other forms of therapeutic anticoagulation (25).
T70 10688-10956 Sentence denotes To address this question, a total of 18 clinical trials, 9 of which are recruiting, have been registered with the National Institutes of Health (https://www.clinicaltrials.gov/; as of June 2, 2020) to investigate the utility of therapeutic anticoagulation in COVID-19.
T71 10958-11016 Sentence denotes PRECLINICAL EVIDENCE FOR HEPARIN AS A SARS-CoV-2 ANTIVIRAL
T72 11017-11183 Sentence denotes Beyond anticoagulation, there may be alternative beneficial mechanisms of action for heparin in patients with COVID-19 including direct SARS-CoV-2 antiviral activity.
T73 11184-11515 Sentence denotes In a similar fashion to the related viruses severe acute respiratory coronavirus (SARS-CoV) and Middle East respiratory syndrome coronavirus (MERS-CoV), host cell fusion and entry are thought to be accomplished in SARS-CoV-2 infection via binding of the viral spike protein to host angiotensin-converting enzyme 2 (ACE2) receptors.
T74 11516-11818 Sentence denotes Cofactors for this binding are incompletely understood for SARS-CoV-2; however, in vitro studies have demonstrated that cell surface heparan sulfate (the class of glycosaminoglycans of which heparin is composed) is essential for entry and infectivity with human coronavirus NL63 (23) and SARS-CoV (19).
T75 11819-12016 Sentence denotes Heparan sulfate is thought to interact with the spike protein as an adhesion molecule coreceptor, which may be the first step in facilitating the interaction of SARS-CoV and the ACE2 receptor (23).
T76 12017-12237 Sentence denotes It has recently been discovered that concordant with other coronaviruses, the SARS-CoV-2 spike protein also interacts with heparan sulfate, and with a higher affinity than either SARS-CoV or MERS-CoV spike proteins (17).
T77 12238-12403 Sentence denotes In this study by Kim et al., the SARS-CoV-2 spike protein demonstrated extremely strong (and nearly irreversible) binding to heparin using surface plasmon resonance.
T78 12404-12525 Sentence denotes Our developing understanding of the virology of SARS-CoV-2 suggests the biologic plausibility of heparin as an antiviral.
T79 12526-12672 Sentence denotes Theoretically, heparin may bind the SARS-CoV-2 spike protein and function as a competitive inhibitor for viral entry, thus decreasing infectivity.
T80 12673-12978 Sentence denotes Interestingly, shorter-length heparins, comparable to those found in therapeutic low-molecular weight heparin, did not appreciably bind the spike protein (17), suggesting that low-molecular weight formulations may be less likely to have direct antiviral activity through competitive spike protein binding.
T81 12979-13187 Sentence denotes If clinical trials demonstrate benefit of unfractionated heparin therapy, its effect could be partially due to this theoretical antiviral activity, rather than solely due to its anticoagulant properties (38).
T82 13188-13351 Sentence denotes As such, clinical trials with heparin should evaluate disease course and time to clearance of infection, as these outcomes would support direct antiviral activity.
T83 13352-13469 Sentence denotes Despite the promise of this concept, no clinical data linking heparin therapy to meaningful antiviral outcomes exist.
T84 13470-13607 Sentence denotes However, the use of heparin and other glycosaminoglycans as antiviral therapy has significant potential for future clinical applications.
T85 13608-13806 Sentence denotes The utilization of heparan sulfate as a cofactor for viral entry appears to be conserved across the human coronaviruses as discussed, as well as the hepatitis C virus and herpesvirus family (8, 37).
T86 13807-14041 Sentence denotes With a more in-depth understanding, this therapeutic strategy could be optimized for COVID-19, which may inform broad antiviral treatment with heparin and heparin-like drugs for future zoonotic coronaviruses and other viral pathogens.
T87 14043-14113 Sentence denotes ANTI-INFLAMMATORY EFFECTS OF HEPARIN-LIKE DRUGS: RELEVANCE TO COVID-19
T88 14114-14273 Sentence denotes Heparin is known to have anti-inflammatory effects both in the vasculature and in the airway, which could beneficially impact COVID-19-associated inflammation.
T89 14274-14562 Sentence denotes Heparin binds to and modulates the activity of many proteins that mediate inflammation including IL-8, platelet growth factor 4 (PGF4), stromal-derived factor 1a, neutrophil elastase, P- and L-selectin, CD11b/CD18, major basic protein (MBP), and eosinophil cationic protein (ECP; 13, 47).
T90 14563-14701 Sentence denotes The anti-inflammatory effects of heparin and its constituent heparan sulfate glycosaminoglycan fragments fall into two general mechanisms:
T91 14702-14863 Sentence denotes 1) dampening of inflammation through interaction with proinflammatory proteins and 2) preventing adhesion and an influx of inflammatory cells to a diseased area.
T92 14864-15010 Sentence denotes There are innumerable studies that have demonstrated that heparin can dampen inflammation through its interaction with key inflammatory mediators.
T93 15011-15404 Sentence denotes The proinflammatory transcription factor nuclear factor-κB (NF-κB), which has been found to be involved in the pathogenesis of SARS-CoV, the virus underlying the 2003 severe acute respiratory syndrome (SARS) epidemic (16), leads to the production of downstream inflammatory cytokines and other immune response proteins including tumor necrosis factor-α (TNF-α), IL-1β, IL-6, and IL-8 (13, 47).
T94 15405-15533 Sentence denotes Heparin has been observed to directly dampen NF-κB signaling in LPS-stimulated human endothelial cells and human monocytes (21).
T95 15534-15759 Sentence denotes Similarly, a synthetic heparin-like drug has recently been developed that neutralizes high mobility group box 1 (HMGB1; 5), a proinflammatory mediator that is known to play a role in the pathogenesis of viral infections (15).
T96 15760-16053 Sentence denotes With respect to inflammatory cell infiltration, a phenomenon that has been observed pathologically in COVID-19 (2, 39), heparin can directly interact with vascular endothelial cells leading to reduced recruitment of the innate immune system and direct inhibition of neutrophil activation (13).
T97 16054-16223 Sentence denotes More broadly, heparin has been shown to dampen inflammation in other preclinical models characterized by robust inflammation including pancreatitis (12) and sepsis (33).
T98 16224-16450 Sentence denotes Clinically, the use of heparin as an anti-inflammatory agent has shown limited evidence of benefit in human diseases including inflammatory bowel disease, asthma, reactive airways disease, and acute coronary syndrome (13, 24).
T99 16451-16607 Sentence denotes Despite this clinical evidence, heparin has not been approved by the US Federal Drug Administration as a direct anti-inflammatory for any medical condition.
T100 16609-16668 Sentence denotes POTENTIAL ADVERSE AND OFF-TARGET EFFECTS OF HEPARIN THERAPY
T101 16669-16785 Sentence denotes The use of heparin as a therapeutic anticoagulant is associated with a 10–15% risk of significant bleeding (11, 27).
T102 16786-17004 Sentence denotes Factors that may increase bleeding risk are older age, worse illness severity, recent trauma or surgery, cardiopulmonary resuscitation, longer hospital stay, and decreased white blood cell and platelet counts (11, 27).
T103 17005-17089 Sentence denotes Many of these risk factors for bleeding are commonly seen in patients with COVID-19.
T104 17090-17227 Sentence denotes A second, albeit rare, complication of heparin therapy is HIT, which is estimated to occur in 0.2–3% of patients who receive heparin (4).
T105 17228-17432 Sentence denotes This feared adverse effect is driven by the development of antibodies specific to the protein platelet factor 4, which leads to life-threatening thrombocytopenia and paradoxical development of thrombosis.
T106 17433-17611 Sentence denotes It is also possible that the intended effect of heparin (i.e., anticoagulation) can interrupt lung-protective processes of coagulation that may improve host survival in COVID-19.
T107 17612-17847 Sentence denotes Although critical illness-associated intravascular thrombosis has been recognized as harmful in animal models of lung injury (44), coagulation occurring within alveoli and airways has generally been found to be lung protective (9, 34).
T108 17848-18032 Sentence denotes This is particularly notable in animal models of viral pneumonia, in which transgenic loss of epithelial tissue factor markedly worsened animal mortality after influenza infection (3).
T109 18033-18133 Sentence denotes Transgenic loss of endothelial tissue factor, conversely, had no effect on influenza-induced injury.
T110 18134-18307 Sentence denotes It is therefore possible that intra-alveolar coagulation may serve a teleological function of isolating pulmonary pathogens, protecting the host from disseminated infection.
T111 18308-18514 Sentence denotes Such divergent effects of intra-alveolar and intravascular coagulation may in part explain the muted benefits of anticoagulants [including inhaled heparin (6)] in randomized controlled studies of pneumonia.
T112 18515-18642 Sentence denotes Finally, heparin may have many other unrecognized effects—both protective and harmful—arising from its heterogeneous structure.
T113 18643-18988 Sentence denotes As noted, unfractionated heparin is composed of a mixture of distinct biologically derived (i.e., porcine intestinal mucosae) heparan sulfate polysaccharides, which on balance not only is enriched in a pentasaccharide sequence necessary for AT3 activation (and thus anticoagulation) but also displays a wide variety of other sulfation sequences.
T114 18989-19169 Sentence denotes These non-anticoagulant sulfation sequences allow heparin binding to various growth factors, potentially exerting both organ-protective (46, 49) and organ-harmful (14, 20) effects.
T115 19171-19182 Sentence denotes CONCLUSIONS
T116 19183-19242 Sentence denotes There is a paucity of pharmacologic therapies for COVID-19.
T117 19243-19457 Sentence denotes Although heparin may prove beneficial in treating the coagulopathy of this disease, utilization of therapeutic anticoagulation before the development of thrombosis in COVID-19 has not been systematically evaluated.
T118 19458-19682 Sentence denotes Additionally, although heparin is known to possess non-anticoagulant effects that may be beneficial in COVID-19 (i.e., direct antiviral and anti-inflammatory), the balance between its benefits and risks should be considered.
T119 19683-19930 Sentence denotes Given the potential benefits (and uncertain risks) of therapeutic heparin (see Fig. 3), tempered by the failures of previous studies targeting coagulopathy in critical illness, randomized clinical trials of heparin in COVID-19 are urgently needed.
T120 19931-19938 Sentence denotes Fig. 3.
T121 19940-20031 Sentence denotes Summary of potential therapeutic effects of heparin in coronavirus disease 2019 (COVID-19).
T122 20032-20257 Sentence denotes 1) Heparin’s classic function as an anticoagulant, through its interaction with antithrombin-III (AT3), may prove beneficial because of the high prevalence of coagulopathy and clinically significant thrombosis in the disease.
T123 20258-20571 Sentence denotes 2) Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) entry into both endothelial and epithelial cells is believed to be dependent on its interaction with cell surface heparan sulfate; thus, heparin (or carefully designed synthetic heparin-like drugs) may inhibit this interaction and block viral entry.
T124 20572-20661 Sentence denotes 3) Last, heparin has known anti-inflammatory effects that may confer benefit in COVID-19.
T125 20662-20732 Sentence denotes This illustration was created with BioRender (https://biorender.com/).
T126 20733-21053 Sentence denotes ACE2, angiotensin-converting enzyme 2; APC, activated protein C; HS, heparan sulfate; IL, interleukin; PAI-1, plasminogen activator inhibitor 1; TF, tissue factor; TFPI, tissue factor pathway inhibitor; TNF, tumor necrosis factor; tPA, tissue plasminogen activator; uPA, urokinase plasminogen activator, VII, factor VII.
T127 21055-21061 Sentence denotes GRANTS
T128 21062-21167 Sentence denotes This work was supported by NIH, US Department of Health and Human Services, Grant F31-HL-143873 (W.B.L.).
T129 21169-21180 Sentence denotes DISCLOSURES
T130 21181-21259 Sentence denotes No conflicts of interest, financial or otherwise, are declared by the authors.
T131 21261-21281 Sentence denotes AUTHOR CONTRIBUTIONS
T132 21282-21624 Sentence denotes J.A.H., W.B.L., J.F.C., C.J.L.-A., and E.P.S. conceived and designed research; J.A.H., W.B.L., and E.P.S. prepared figures; J.A.H., W.B.L., J.F.C., C.J.L.-A., and E.P.S. drafted manuscript; J.A.H., W.B.L., J.F.C., and C.J.L.-A. edited and revised manuscript; J.A.H., W.B.L., J.F.C., C.J.L.-A., and E.P.S. approved final version of manuscript.

LitCovid-PD-GlycoEpitope

Id Subject Object Predicate Lexical cue glyco_epitope_db_id
T1 3055-3070 GlycoEpitope denotes heparan sulfate http://www.glycoepitope.jp/epitopes/EP0086
T2 3072-3074 GlycoEpitope denotes HS http://www.glycoepitope.jp/epitopes/EP0086
T3 3181-3183 GlycoEpitope denotes HS http://www.glycoepitope.jp/epitopes/EP0086
T4 3641-3643 GlycoEpitope denotes HS http://www.glycoepitope.jp/epitopes/EP0086
T5 4034-4049 GlycoEpitope denotes heparan sulfate http://www.glycoepitope.jp/epitopes/EP0086
T6 4051-4053 GlycoEpitope denotes HS http://www.glycoepitope.jp/epitopes/EP0086
T7 4080-4082 GlycoEpitope denotes HS http://www.glycoepitope.jp/epitopes/EP0086
T8 4346-4348 GlycoEpitope denotes HS http://www.glycoepitope.jp/epitopes/EP0086
T9 4441-4443 GlycoEpitope denotes HS http://www.glycoepitope.jp/epitopes/EP0086
T10 11649-11664 GlycoEpitope denotes heparan sulfate http://www.glycoepitope.jp/epitopes/EP0086
T11 11819-11834 GlycoEpitope denotes Heparan sulfate http://www.glycoepitope.jp/epitopes/EP0086
T12 12140-12155 GlycoEpitope denotes heparan sulfate http://www.glycoepitope.jp/epitopes/EP0086
T13 13627-13642 GlycoEpitope denotes heparan sulfate http://www.glycoepitope.jp/epitopes/EP0086
T14 14624-14639 GlycoEpitope denotes heparan sulfate http://www.glycoepitope.jp/epitopes/EP0086
T15 18769-18784 GlycoEpitope denotes heparan sulfate http://www.glycoepitope.jp/epitopes/EP0086
T16 20436-20451 GlycoEpitope denotes heparan sulfate http://www.glycoepitope.jp/epitopes/EP0086
T17 20798-20800 GlycoEpitope denotes HS http://www.glycoepitope.jp/epitopes/EP0086
T18 20802-20817 GlycoEpitope denotes heparan sulfate http://www.glycoepitope.jp/epitopes/EP0086

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T1 561-579 Phenotype denotes hypercoagulability http://purl.obolibrary.org/obo/HP_0100724
T2 2912-2944 Phenotype denotes heparin-induced thrombocytopenia http://purl.obolibrary.org/obo/HP_0011874
T3 2946-2949 Phenotype denotes HIT http://purl.obolibrary.org/obo/HP_0011874
T4 4888-4900 Phenotype denotes COAGULOPATHY http://purl.obolibrary.org/obo/HP_0003256
T5 4989-5001 Phenotype denotes coagulopathy http://purl.obolibrary.org/obo/HP_0003256
T6 5015-5027 Phenotype denotes coagulopathy http://purl.obolibrary.org/obo/HP_0003256
T7 5073-5089 Phenotype denotes thrombocytopenia http://purl.obolibrary.org/obo/HP_0001873
T8 5097-5129 Phenotype denotes prolongation of prothrombin time http://purl.obolibrary.org/obo/HP_0008151
T9 5131-5133 Phenotype denotes PT http://purl.obolibrary.org/obo/HP_0008151
T10 5248-5260 Phenotype denotes coagulopathy http://purl.obolibrary.org/obo/HP_0003256
T11 5831-5846 Phenotype denotes thromboembolism http://purl.obolibrary.org/obo/HP_0001907
T12 6128-6134 Phenotype denotes sepsis http://purl.obolibrary.org/obo/HP_0100806
T13 6266-6284 Phenotype denotes hypercoagulability http://purl.obolibrary.org/obo/HP_0100724
T14 6507-6519 Phenotype denotes coagulopathy http://purl.obolibrary.org/obo/HP_0003256
T15 6712-6724 Phenotype denotes coagulopathy http://purl.obolibrary.org/obo/HP_0003256
T16 6826-6838 Phenotype denotes coagulopathy http://purl.obolibrary.org/obo/HP_0003256
T17 6903-6909 Phenotype denotes sepsis http://purl.obolibrary.org/obo/HP_0100806
T18 7099-7111 Phenotype denotes coagulopathy http://purl.obolibrary.org/obo/HP_0003256
T19 7115-7121 Phenotype denotes sepsis http://purl.obolibrary.org/obo/HP_0100806
T20 7302-7314 Phenotype denotes coagulopathy http://purl.obolibrary.org/obo/HP_0003256
T21 7343-7355 Phenotype denotes coagulopathy http://purl.obolibrary.org/obo/HP_0003256
T22 7387-7393 Phenotype denotes sepsis http://purl.obolibrary.org/obo/HP_0100806
T23 7641-7653 Phenotype denotes Coagulopathy http://purl.obolibrary.org/obo/HP_0003256
T24 7657-7663 Phenotype denotes sepsis http://purl.obolibrary.org/obo/HP_0100806
T25 7758-7770 Phenotype denotes coagulopathy http://purl.obolibrary.org/obo/HP_0003256
T26 7834-7840 Phenotype denotes sepsis http://purl.obolibrary.org/obo/HP_0100806
T27 8217-8229 Phenotype denotes coagulopathy http://purl.obolibrary.org/obo/HP_0003256
T28 8771-8787 Phenotype denotes elevated D-dimer http://purl.obolibrary.org/obo/HP_0033106
T29 8848-8854 Phenotype denotes sepsis http://purl.obolibrary.org/obo/HP_0100806
T30 8863-8875 Phenotype denotes coagulopathy http://purl.obolibrary.org/obo/HP_0003256
T31 9133-9153 Phenotype denotes respiratory distress http://purl.obolibrary.org/obo/HP_0002098
T32 13757-13766 Phenotype denotes hepatitis http://purl.obolibrary.org/obo/HP_0012115
T33 15340-15345 Phenotype denotes tumor http://purl.obolibrary.org/obo/HP_0002664
T34 16189-16201 Phenotype denotes pancreatitis http://purl.obolibrary.org/obo/HP_0001733
T35 16211-16217 Phenotype denotes sepsis http://purl.obolibrary.org/obo/HP_0100806
T36 16351-16377 Phenotype denotes inflammatory bowel disease http://purl.obolibrary.org/obo/HP_0002037
T37 16379-16385 Phenotype denotes asthma http://purl.obolibrary.org/obo/HP_0002099
T38 16387-16411 Phenotype denotes reactive airways disease http://purl.obolibrary.org/obo/HP_0002099
T39 17148-17151 Phenotype denotes HIT http://purl.obolibrary.org/obo/HP_0011874
T40 17373-17389 Phenotype denotes thrombocytopenia http://purl.obolibrary.org/obo/HP_0001873
T41 17903-17912 Phenotype denotes pneumonia http://purl.obolibrary.org/obo/HP_0002090
T42 18504-18513 Phenotype denotes pneumonia http://purl.obolibrary.org/obo/HP_0002090
T43 19297-19309 Phenotype denotes coagulopathy http://purl.obolibrary.org/obo/HP_0003256
T44 19826-19838 Phenotype denotes coagulopathy http://purl.obolibrary.org/obo/HP_0003256
T45 20191-20203 Phenotype denotes coagulopathy http://purl.obolibrary.org/obo/HP_0003256
T46 20941-20946 Phenotype denotes tumor http://purl.obolibrary.org/obo/HP_0002664

2_test

Id Subject Object Predicate Lexical cue
32519894-31978945-2138149 1734-1736 31978945 denotes 50
32519894-28653068-2138150 3292-3294 28653068 denotes 43
32519894-26947929-2138151 4479-4480 26947929 denotes 3
32519894-32302462-2138152 5003-5004 32302462 denotes 7
32519894-32320003-2138153 5006-5008 32320003 denotes 32
32519894-32302462-2138154 5262-5263 32302462 denotes 7
32519894-32437596-2138155 5440-5441 32437596 denotes 2
32519894-32325026-2138156 5552-5554 32325026 denotes 39
32519894-32291094-2138157 6018-6020 32291094 denotes 18
32519894-32353746-2138158 6022-6024 32353746 denotes 22
32519894-19132200-2138159 6120-6122 19132200 denotes 36
32519894-16310605-2138160 6142-6144 16310605 denotes 30
32519894-32343504-2138161 6286-6288 32343504 denotes 28
32519894-32374815-2138162 6448-6450 32374815 denotes 45
32519894-11236773-2138163 7041-7043 11236773 denotes 10
32519894-32320003-2138164 7045-7047 32320003 denotes 32
32519894-32220112-2138165 7049-7051 32220112 denotes 38
32519894-31104069-2138166 7053-7055 31104069 denotes 40
32519894-31104069-2138167 7143-7145 31104069 denotes 40
32519894-11597289-2138168 7153-7155 11597289 denotes 42
32519894-12851279-2138169 7191-7192 12851279 denotes 1
32519894-22616830-2138170 7220-7222 22616830 denotes 31
32519894-11236773-2138171 7935-7937 11236773 denotes 10
32519894-31104069-2138172 7956-7958 31104069 denotes 40
32519894-32220112-2138173 7974-7976 32220112 denotes 38
32519894-32320003-2138174 8002-8004 32320003 denotes 32
32519894-30300652-2138175 8569-8571 30300652 denotes 48
32519894-32220112-2138176 8970-8972 32220112 denotes 38
32519894-32267998-2138177 9227-9229 32267998 denotes 41
32519894-32387623-2138178 9549-9551 32387623 denotes 29
32519894-29142129-2138179 11796-11798 29142129 denotes 23
32519894-21887302-2138180 11814-11816 21887302 denotes 19
32519894-29142129-2138181 12012-12014 29142129 denotes 23
32519894-32220112-2138182 13183-13185 32220112 denotes 38
32519894-16928753-2138183 13799-13800 16928753 denotes 8
32519894-11518721-2138184 13802-13804 11518721 denotes 37
32519894-31030744-2138185 14554-14556 31030744 denotes 13
32519894-17727922-2138186 14558-14560 17727922 denotes 47
32519894-17141229-2138187 15229-15231 17141229 denotes 16
32519894-31030744-2138188 15396-15398 31030744 denotes 13
32519894-17727922-2138189 15400-15402 17727922 denotes 47
32519894-32063752-2138190 15529-15531 32063752 denotes 21
32519894-32188725-2138191 15654-15655 32188725 denotes 5
32519894-24717031-2138192 15755-15757 24717031 denotes 15
32519894-32437596-2138193 15872-15873 32437596 denotes 2
32519894-32325026-2138194 15875-15877 32325026 denotes 39
32519894-31030744-2138195 16049-16051 31030744 denotes 13
32519894-14739847-2138196 16203-16205 14739847 denotes 12
32519894-22820644-2138197 16219-16221 22820644 denotes 33
32519894-31030744-2138198 16442-16444 31030744 denotes 13
32519894-26064103-2138199 16446-16448 26064103 denotes 24
32519894-20442353-2138200 16777-16779 20442353 denotes 11
32519894-1657248-2138201 16781-16783 1657248 denotes 27
32519894-20442353-2138202 16996-16998 20442353 denotes 11
32519894-1657248-2138203 17000-17002 1657248 denotes 27
32519894-28416511-2138204 17224-17225 28416511 denotes 4
32519894-11734456-2138205 17738-17740 11734456 denotes 44
32519894-23033361-2138206 17840-17841 23033361 denotes 9
32519894-25884207-2138207 17843-17845 25884207 denotes 34
32519894-26947929-2138208 18029-18030 26947929 denotes 3
32519894-27288618-2138209 18464-18465 27288618 denotes 6
32519894-28187268-2138210 19126-19128 28187268 denotes 46
32519894-28538085-2138211 19130-19132 28538085 denotes 49
32519894-30720464-2138212 19153-19155 30720464 denotes 14
32519894-32320623-2138213 19157-19159 32320623 denotes 20